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AKNTAWQSLWRSISQRPVESYNKAWLGAIALAVIGALVGAMLLVKAIGLGYSHYTGEFLQAASLQPGANV SYAGVPVGNVTSVELAGDRIEVGMRVRDDITLRKDARASIKITTILGNQYVELRNGGDGTLPNRRIDLAH TEVPYDLQATLQDATSTFEQVDADKIAESTAILAKQLEGLPAVLPQAMENIQTLSSVISHRRDQIGTLLS STELVAGTLHRQQGDIGKLIVQGRDLLGEFVSRQASFHSMMRAVTELVDVLNKIVVKDRGAVDKLIADVK TFSNLIGGHDDLFRSLLQVTAVAARNFTNLTGYGNALELSAPGGLAVDSWMCAISGRAKQFNMIPYFKDC Q*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4566c | - | - | 100% (352) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1008c | - | e-123 | 60.52% (347) | putative MCE family protein |
| M. abscessus ATCC 19977 | MAB_4514c | - | e-120 | 59.08% (347) | putative Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0606 | mce2C | 3e-21 | 24.72% (271) | MCE-family protein MCE2C |
| M. gilvum PYR-GCK | Mflv_0008 | - | 1e-112 | 56.97% (337) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0591 | mce2C | 2e-21 | 24.72% (271) | MCE-family protein MCE2C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 2e-18 | 22.66% (278) | putative secreted protein |
| M. marinum M | MMAR_0179 | mce6C | 1e-110 | 58.21% (335) | MCE-family protein Mce6C |
| M. avium 104 | MAV_2386 | - | 1e-117 | 58.82% (340) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_1145 | - | 1e-109 | 54.60% (337) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2869 | - | 1e-108 | 56.59% (334) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4917 | mce6C | 1e-108 | 57.31% (335) | MCE-family protein Mce6C |
| M. vanbaalenii PYR-1 | Mvan_0961 | - | 1e-111 | 55.72% (341) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0179|M.marinum_M MAERIKHLRPR----LRPLASYNKTWLGFVGLSLAVVLIGALLLVKQAGI
MUL_4917|M.ulcerans_Agy99 MAERIKHLRPR----LRPLASYNKTWLGFVGLSLAVVMIGALLLVKQGGI
MAB_4566c|M.abscessus_ATCC_199 MAKNTAWQSLWRSISQRPVESYNKAWLGAIALAVIGALVGAMLLVKAIGL
Mflv_0008|M.gilvum_PYR-GCK MAEQTK-RRRR------RLESYHKAWLGTVAVVVVAVLVGALLLIKAADV
Mvan_0961|M.vanbaalenii_PYR-1 MAERRK-WPRR------PLESYHSAWLGFAAVAVVAVLIGAMLLIKGADV
MSMEG_1145|M.smegmatis_MC2_155 MAEARKARRRK------PLESYNRLWLGVVAVAVVSVLIGAMLLVRVADI
TH_2869|M.thermoresistible__bu ------------------LETYSRTTLGVIAVAVVAVLVGALLVVKAAGI
MAV_2386|M.avium_104 MRQRLSALTKR------PLESYNKTWLGFVAVAVVAAVIAVMLVVHALGA
Mb0606|M.bovis_AF2122/97 ---------------MRTLTEFNRGRVGMMGAVVTVLVVGVAQSFTSVPM
Rv0591|M.tuberculosis_H37Rv ---------------MRTLTEFNRGRVGMMGAVVTVLVVGVAQSFTSVPM
MLBr_02591|M.leprae_Br4923 ---------------MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPI
: * . : ::.. .
MMAR_0179|M.marinum_M GYR--RYTAEFLQAASLQPDNVVSVAGVPVGNVISVRLAGDHVEARLRVK
MUL_4917|M.ulcerans_Agy99 GYR--RYTAEFLQAASLQPDNVVSVAGVPVGNVISVRLAGNHVEARLRVK
MAB_4566c|M.abscessus_ATCC_199 GYS--HYTGEFLQAASLQPGANVSYAGVPVGNVTSVELAGDRIEVGMRVR
Mflv_0008|M.gilvum_PYR-GCK GYR--TFTAQFLQAAALQPGNPVSVAGIPVGEVTDMKLAGDHVEARFTVR
Mvan_0961|M.vanbaalenii_PYR-1 GYR--KYTAQFLQAAALQPGNPVTVAGIPVGEVTGMELAGDHVVADFTVR
MSMEG_1145|M.smegmatis_MC2_155 GYT--QYTARFLQAAALKAGNPVTVAGIPVGEVKSMRLAGDHVEAKIKVR
TH_2869|M.thermoresistible__bu GYK--EYTARFLQAAALQPGNPITVAGIPVGEVLSMKLNGDHVEARLKVR
MAV_2386|M.avium_104 GYR--HYTAEFAQAASLRAGNPIVVAGIPVGTVTSMKLVGDHVEAGLKVR
Mb0606|M.bovis_AF2122/97 LFATPTYYAQFADMGGINTGDKVEIAGVNVGLVRSLAIRGNRVLIGFSLP
Rv0591|M.tuberculosis_H37Rv LFATPTYYAQFADTGGINTGDKVEIAGVNVGLVRSLAIRGNRVLIGFSLP
MLBr_02591|M.leprae_Br4923 LFARPSYYGQFTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG
: : ..* : ..:. . : **: ** * : : *::: : :
MMAR_0179|M.marinum_M DNIALGRDTRAAIKITTIFGSRYIDLHPTGAGVP-PGQTIDLAHTEVPYD
MUL_4917|M.ulcerans_Agy99 DNIALGRDTRAAIKITTIFGSRYIDLHPTGAGVP-PGQTIDLAHTEVPYD
MAB_4566c|M.abscessus_ATCC_199 DDITLRKDARASIKITTILGNQYVELRNGGDGTL-PNRRIDLAHTEVPYD
Mflv_0008|M.gilvum_PYR-GCK NDVDLGEDSRAVIKVTTILGSRYLSLEPEGTGAL-PDRHFDLSHTEVPYD
Mvan_0961|M.vanbaalenii_PYR-1 NDVALGEDSRAVIKVTTILGSRYLSLEPEGPGSL-PDRRFDLAHTEVPYD
MSMEG_1145|M.smegmatis_MC2_155 NDVGLGKDSRAKIMVTTILGSRYLSLEPAGDGTL-PDRTFDLSHTDVPYD
TH_2869|M.thermoresistible__bu GDIRLGEHSRAVIKITTILGSRYLALYPDGPGTL-PDNTFDLKHTEVPYD
MAV_2386|M.avium_104 DNISFGKDSRAQIRVTTILGSRYLALEPNGPARL-PGNTFDLAHTEVPYD
Mb0606|M.bovis_AF2122/97 -GKTIGMQSRAAIRTDTILGRKNLEIEPRGSEPLKPNGFLPLAQTTTPYQ
Rv0591|M.tuberculosis_H37Rv -GKTIGMQSRAAIRTDTILGRKNLEIEPRGSEPLKPNGFLPLAQTTTPYQ
MLBr_02591|M.leprae_Br4923 -TNRIGTASRLGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQ
: :* * *::* : : : * *. : * :: .**:
MMAR_0179|M.marinum_M LQAALADSTRTFEQVDGDRIASSLTVLGQALNGLPDVFPQALENVRALSS
MUL_4917|M.ulcerans_Agy99 LQAALADSTRTFEQVDGDRIASSLTVLGQALNGLPDVFPQALENVRALSS
MAB_4566c|M.abscessus_ATCC_199 LQATLQDATSTFEQVDADKIAESTAILAKQLEGLPAVLPQAMENIQTLSS
Mflv_0008|M.gilvum_PYR-GCK LQEALTDVTTTFEQVDSDKFAETLSILGRQLQGMPEILPQALENTHTLST
Mvan_0961|M.vanbaalenii_PYR-1 LQEALTDVATTFEQVDSDKFAESLAILGRQLQGLPEVVPQALQNTHTLST
MSMEG_1145|M.smegmatis_MC2_155 LQEALTDVTTTFEKVDSDKFAETLQILGSQLETLPPVIPQALENTHTLST
TH_2869|M.thermoresistible__bu LQEALADVATTYEQVDSDQFAESLAILGRQLETLPPVVPQALENTHTLSS
MAV_2386|M.avium_104 LQAALQDATTTFEQVDSDRFAQSLAVLGKQLEGLPAVVPQAITNIDTLSS
Mb0606|M.bovis_AF2122/97 IYDAFVDVTKAATGWDIDAVKRSLNVLSETFDQTAPHLSAALEGVKAFSD
Rv0591|M.tuberculosis_H37Rv IYDAFVDVTKAATGWDIDAVKRSLNVLSETFDQTAPHLSAALEGVKAFSD
MLBr_02591|M.leprae_Br4923 SYDAFFDATKVASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSD
:: * : . : * . : ::. :: .. *: . :*
MMAR_0179|M.marinum_M VISQRRDQLGTLLKSTQNVTDILRRQQSDLGSMIRQGQDLIGEFVAHSAA
MUL_4917|M.ulcerans_Agy99 VISQRRDQLGTLLKSTQNVTDILRRQQSDLGSMIRQGQDLIGEFVAHSAA
MAB_4566c|M.abscessus_ATCC_199 VISHRRDQIGTLLSSTELVAGTLHRQQGDIGKLIVQGRDLLGEFVSRQAS
Mflv_0008|M.gilvum_PYR-GCK IIADRRDQLGSLLETTEVVSNTLRRQQANIGSLVRQGNDLVGEFVLRRAS
Mvan_0961|M.vanbaalenii_PYR-1 ILAQRRDQLGALLETTDVVSTTLKRQQSNIASMVRQGNDLVGEFVVRRAS
MSMEG_1145|M.smegmatis_MC2_155 IIAQRRDQLGELLKTTELISNTLYRQKSTIGSLMNQSNSLLAEFVARRAT
TH_2869|M.thermoresistible__bu IIAQRRDQLGELLKTTEMVSTTLRRQQANIGNLVHQGNSLLGEFVARRAT
MAV_2386|M.avium_104 IIATRRDQLGQLLRSTEQVTNTLRRQQAGIGALVDQGQDLLGQFVARRAV
Mb0606|M.bovis_AF2122/97 TVGRRGEQIEQLLANANRIARVLGDRSEQVNGLLVNAKTLLAAFKQRSQA
Rv0591|M.tuberculosis_H37Rv TVGRRGEQIEQLLANANRIARVLGDRSEQVNGLLVNAKTLLAAFKQRSQA
MLBr_02591|M.leprae_Br4923 TIGARDKEIKHLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRA
:. * .:: *: :: :: * : : :: : . *:. * :
MMAR_0179|M.marinum_M FHAMMQALTQVVGSLRTIVVDDRAALEDVVQTMEQLSAKLAEQDALFRNL
MUL_4917|M.ulcerans_Agy99 FHAMMQALTQVVGSLRTIVVDDRAALEDVVQTMEQLSAKLAEQDALFRNL
MAB_4566c|M.abscessus_ATCC_199 FHSMMRAVTELVDVLNKIVVKDRGAVDKLIADVKTFSNLIGGHDDLFRSL
Mflv_0008|M.gilvum_PYR-GCK FQAMMNAITNLVQTLGDIVIEDRPELEALLVNVRELSDMLGQHDDLLRSI
Mvan_0961|M.vanbaalenii_PYR-1 FHAMLAAITDLVQTLSDIVIGDRPELEALLVNVRELSDMLGQHDDLVRNI
MSMEG_1145|M.smegmatis_MC2_155 FHAMMDALTNLVQTLSGIVIDDRPELEKLVEDLRQLSSLLSKNDGMLRSI
TH_2869|M.thermoresistible__bu FHAMMDALTVLVQRLSDIVIDDRPELEELLSNLRELSGLLADNDGMLRSI
MAV_2386|M.avium_104 FHAMMRSLSSLVDTLSRVVVNDRSGVDALLKDIRDFTGLVSAHDDLLHSL
Mb0606|M.bovis_AF2122/97 LRILLTNVSEASAQVSGLIT-DNPNLNHVLAQLRTVSEELVKRKNELADV
Rv0591|M.tuberculosis_H37Rv LRILLTNVSEASAQVSGLIT-DNPNLNHVLAQLRTVSEELVKRKNELADV
MLBr_02591|M.leprae_Br4923 VDALLGNVAAFAAQVQRLIN-DNPNLNHVLEQLHQLSGILVQHKDDLANT
. :: :: : :: *. :: :: :. .: : .. . .
MMAR_0179|M.marinum_M LEIAPVPVRELANASGYG---NALELNAAAGPLVDSWMCAISGR----AK
MUL_4917|M.ulcerans_Agy99 LEIAPVPVRELANASGYG---NALEINAAAGPLVDSWMCAISGR----AK
MAB_4566c|M.abscessus_ATCC_199 LQVTAVAARNFTNLTGYG---NALELSAPGGLAVDSWMCAISGR----AK
Mflv_0008|M.gilvum_PYR-GCK LQSGPPALRGLANATGMG---NAVEFNAANGLLVDSWMCAISGR----AK
Mvan_0961|M.vanbaalenii_PYR-1 LQSGPLALRGLANATGSG---NAVDFNAANGLLVDSWMCAISGR----AK
MSMEG_1145|M.smegmatis_MC2_155 LQTAPIALRNIANMTGTG---NAIDFNSSSGLLVDSWMCAISGR----AK
TH_2869|M.thermoresistible__bu LQTTPIAVRNLANITGTG---NAIDFNAPGGLLVDSWMCAISGR----AK
MAV_2386|M.avium_104 LQVSPIFFREAANLTGDG---NAINFNAPNVPLIDSWMCAISGR----AK
Mb0606|M.bovis_AF2122/97 AVLLGRYTAALTEAVGSGPFFKAMVVNLLPYQILQPWVDAAFKKRGIDPE
Rv0591|M.tuberculosis_H37Rv AVLLGRYTAALTEAVGSGPFFKAMVVNLLPYQILQPWVDAAFKKRGIDPE
MLBr_02591|M.leprae_Br4923 LIQVAAFLPSLNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPE
: * * :.: . ::.*: * : .:
MMAR_0179|M.marinum_M QFGLIQYFKDCA--------------------------------------
MUL_4917|M.ulcerans_Agy99 QFGLIQYFKDCA--------------------------------------
MAB_4566c|M.abscessus_ATCC_199 QFNMIPYFKDCQ--------------------------------------
Mflv_0008|M.gilvum_PYR-GCK QFGMIQYFQDCK--------------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 QFGMIEYLKDCK--------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 QFGMIQYFQDCK--------------------------------------
TH_2869|M.thermoresistible__bu QFGMIEYFQDCK--------------------------------------
MAV_2386|M.avium_104 QFGMIQYFKDCK--------------------------------------
Mb0606|M.bovis_AF2122/97 NFWRSAGLPEFRWPDPNGTRFPNGAPPAAPPVREGTPKHPGPAVPPGTPC
Rv0591|M.tuberculosis_H37Rv NFWRSAGLPEFRWPDPNGTRFPNGAPPAAPPVREGTPKHPGPAVPPGTPC
MLBr_02591|M.leprae_Br4923 NFWRSAGLPEFRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPC
:* : :
MMAR_0179|M.marinum_M --------------------------------------------------
MUL_4917|M.ulcerans_Agy99 --------------------------------------------------
MAB_4566c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0008|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
TH_2869|M.thermoresistible__bu --------------------------------------------------
MAV_2386|M.avium_104 --------------------------------------------------
Mb0606|M.bovis_AF2122/97 SYTPAAG----------ALPRPDNPLPCAGATVGPFGGPDFPAPLDVQPS
Rv0591|M.tuberculosis_H37Rv SYTPAAG----------ALPRPDTPLPCAGATVGPFGGPDFPAPLDVQPS
MLBr_02591|M.leprae_Br4923 SYTPAHPGGNNTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTS
MMAR_0179|M.marinum_M --------------------------------------------------
MUL_4917|M.ulcerans_Agy99 --------------------------------------------------
MAB_4566c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0008|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
TH_2869|M.thermoresistible__bu --------------------------------------------------
MAV_2386|M.avium_104 --------------------------------------------------
Mb0606|M.bovis_AF2122/97 PPNPDGPPPTPGILSAGRPGEPAPAVPGIPMPLPPNAPPGARTQPLEP--
Rv0591|M.tuberculosis_H37Rv PPNPDGPPPTPGILSAGRPGEPAPAVPGIPMPLPPNAPPGARTQPLEP--
MLBr_02591|M.leprae_Br4923 PPNPDGLPLLPGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAA
MMAR_0179|M.marinum_M ------------------------------------
MUL_4917|M.ulcerans_Agy99 ------------------------------------
MAB_4566c|M.abscessus_ATCC_199 ------------------------------------
Mflv_0008|M.gilvum_PYR-GCK ------------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 ------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 ------------------------------------
TH_2869|M.thermoresistible__bu ------------------------------------
MAV_2386|M.avium_104 ------------------------------------
Mb0606|M.bovis_AF2122/97 --------------------FPDGTGGSNQ------
Rv0591|M.tuberculosis_H37Rv --------------------FPDGTGGSNQ------
MLBr_02591|M.leprae_Br4923 PAQDSSAPHEPREQLSAPLINPGGTGGSGGAGGSRN