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MAERIKHLRPRLRPLASYNKTWLGFVGLSLAVVLIGALLLVKQAGIGYRRYTAEFLQAASLQPDNVVSVA GVPVGNVISVRLAGDHVEARLRVKDNIALGRDTRAAIKITTIFGSRYIDLHPTGAGVPPGQTIDLAHTEV PYDLQAALADSTRTFEQVDGDRIASSLTVLGQALNGLPDVFPQALENVRALSSVISQRRDQLGTLLKSTQ NVTDILRRQQSDLGSMIRQGQDLIGEFVAHSAAFHAMMQALTQVVGSLRTIVVDDRAALEDVVQTMEQLS AKLAEQDALFRNLLEIAPVPVRELANASGYGNALELNAAAGPLVDSWMCAISGRAKQFGLIQYFKDCA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0179 | mce6C | - | 100% (348) | MCE-family protein Mce6C |
| M. marinum M | MMAR_3866 | mce5C | e-108 | 56.94% (346) | Mce family protein, Mce5C |
| M. marinum M | MMAR_4985 | mce4C | 8e-25 | 26.85% (298) | MCE-family protein Mce4C |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 1e-27 | 27.27% (308) | MCE-family protein MCE4C |
| M. gilvum PYR-GCK | Mflv_0008 | - | 1e-113 | 57.35% (347) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3497c | mce4C | 1e-27 | 27.27% (308) | MCE-family protein MCE4C |
| M. leprae Br4923 | MLBr_02590 | mce1B | 6e-21 | 24.07% (295) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1697 | - | 1e-139 | 71.43% (336) | putative Mce family protein |
| M. avium 104 | MAV_2386 | - | 1e-112 | 57.31% (335) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_1145 | - | 1e-110 | 56.38% (337) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2869 | - | 1e-112 | 58.56% (333) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4917 | mce6C | 0.0 | 98.85% (348) | MCE-family protein Mce6C |
| M. vanbaalenii PYR-1 | Mvan_0961 | - | 1e-113 | 57.64% (347) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3527c|M.bovis_AF2122/97 --------MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWP
Rv3497c|M.tuberculosis_H37Rv --------MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWP
MMAR_0179|M.marinum_M MAERIKHLRPRLRPLASYNKTWLGFVGLSLAVVLIGALLLVKQAGIGYR-
MUL_4917|M.ulcerans_Agy99 MAERIKHLRPRLRPLASYNKTWLGFVGLSLAVVMIGALLLVKQGGIGYR-
MAB_1697|M.abscessus_ATCC_1997 ----------MIRPLDSYNKTWLGVAAVAVVAALIGGLLLVKQLGIGYR-
MSMEG_1145|M.smegmatis_MC2_155 MAE--ARKARRRKPLESYNRLWLGVVAVAVVSVLIGAMLLVRVADIGYT-
TH_2869|M.thermoresistible__bu --------------LETYSRTTLGVIAVAVVAVLVGALLVVKAAGIGYK-
Mflv_0008|M.gilvum_PYR-GCK MAE--QTK-RRRRRLESYHKAWLGTVAVVVVAVLVGALLLIKAADVGYR-
Mvan_0961|M.vanbaalenii_PYR-1 MAE--RRK-WPRRPLESYHSAWLGFAAVAVVAVLIGAMLLIKGADVGYR-
MAV_2386|M.avium_104 MRQ--RLSALTKRPLESYNKTWLGFVAVAVVAAVIAVMLVVHALGAGYR-
MLBr_02590|M.leprae_Br4923 ---------------MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFG-
. : . :. : :: . :
Mb3527c|M.bovis_AF2122/97 QGKTYDAYFTDAGGITPGNSVYVSGLKVGAVSAVSLA--GNSAKVTFSVD
Rv3497c|M.tuberculosis_H37Rv QGKTYDAYFTDAGGITPGNSVYVSGLKVGAVSAVSLA--GNSAKVTFSVD
MMAR_0179|M.marinum_M ---RYTAEFLQAASLQPDNVVSVAGVPVGNVISVRLA--GDHVEARLRVK
MUL_4917|M.ulcerans_Agy99 ---RYTAEFLQAASLQPDNVVSVAGVPVGNVISVRLA--GNHVEARLRVK
MAB_1697|M.abscessus_ATCC_1997 ---QFTAEFLQAAALRPGNIVTVAGVQVGSVTGVRLA--GDRVEATFRVR
MSMEG_1145|M.smegmatis_MC2_155 ---QYTARFLQAAALKAGNPVTVAGIPVGEVKSMRLA--GDHVEAKIKVR
TH_2869|M.thermoresistible__bu ---EYTARFLQAAALQPGNPITVAGIPVGEVLSMKLN--GDHVEARLKVR
Mflv_0008|M.gilvum_PYR-GCK ---TFTAQFLQAAALQPGNPVSVAGIPVGEVTDMKLA--GDHVEARFTVR
Mvan_0961|M.vanbaalenii_PYR-1 ---KYTAQFLQAAALQPGNPVTVAGIPVGEVTGMELA--GDHVVADFTVR
MAV_2386|M.avium_104 ---HYTAEFAQAASLRAGNPIVVAGIPVGTVTSMKLV--GDHVEAGLKVR
MLBr_02590|M.leprae_Br4923 RTNGYTAEFTNISGLRTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVD
: * * : ..: ..: : .:*: ** * : * * . . : *
Mb3527c|M.bovis_AF2122/97 RSIVVGDQSLAAIRTDTILGERSIAVSP-AGSGK------STTIPLSRTT
Rv3497c|M.tuberculosis_H37Rv RSIVVGDQSLAAIRTDTILGERSIAVSP-AGSGK------STTIPLSRTT
MMAR_0179|M.marinum_M DNIALGRDTRAAIKITTIFGSRYIDLHP-TGAGVP----PGQTIDLAHTE
MUL_4917|M.ulcerans_Agy99 DNIALGRDTRAAIKITTIFGSRYIDLHP-TGAGVP----PGQTIDLAHTE
MAB_1697|M.abscessus_ATCC_1997 DNMAVGTDSRAAIKITTLFGSRYVDLRP-AGAGTP----AGRRISLQHTE
MSMEG_1145|M.smegmatis_MC2_155 NDVGLGKDSRAKIMVTTILGSRYLSLEP-AGDGTL----PDRTFDLSHTD
TH_2869|M.thermoresistible__bu GDIRLGEHSRAVIKITTILGSRYLALYP-DGPGTL----PDNTFDLKHTE
Mflv_0008|M.gilvum_PYR-GCK NDVDLGEDSRAVIKVTTILGSRYLSLEP-EGTGAL----PDRHFDLSHTE
Mvan_0961|M.vanbaalenii_PYR-1 NDVALGEDSRAVIKVTTILGSRYLSLEP-EGPGSL----PDRRFDLAHTE
MAV_2386|M.avium_104 DNISFGKDSRAQIRVTTILGSRYLALEP-NGPARL----PGNTFDLAHTE
MLBr_02590|M.leprae_Br4923 RSVPLYQSTTAQIRYLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTS
.: . : * * ::*.* : : * . . : * :*
Mb3527c|M.bovis_AF2122/97 TPYTLNGVLQDLGRNANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLT
Rv3497c|M.tuberculosis_H37Rv TPYTLNGVLQDLGRNANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLT
MMAR_0179|M.marinum_M VPYDLQAALADSTRTFEQVDGDRIASSLTVLGQALNGLPDVFPQALENVR
MUL_4917|M.ulcerans_Agy99 VPYDLQAALADSTRTFEQVDGDRIASSLTVLGQALNGLPDVFPQALENVR
MAB_1697|M.abscessus_ATCC_1997 VPYDLQAALADSTRTFEQVDADRIASSLNVLGTQLDGLPGVVPQAMENVR
MSMEG_1145|M.smegmatis_MC2_155 VPYDLQEALTDVTTTFEKVDSDKFAETLQILGSQLETLPPVIPQALENTH
TH_2869|M.thermoresistible__bu VPYDLQEALADVATTYEQVDSDQFAESLAILGRQLETLPPVVPQALENTH
Mflv_0008|M.gilvum_PYR-GCK VPYDLQEALTDVTTTFEQVDSDKFAETLSILGRQLQGMPEILPQALENTH
Mvan_0961|M.vanbaalenii_PYR-1 VPYDLQEALTDVATTFEQVDSDKFAESLAILGRQLQGLPEVVPQALQNTH
MAV_2386|M.avium_104 VPYDLQAALQDATTTFEQVDSDRFAQSLAVLGKQLEGLPAVVPQAITNID
MLBr_02590|M.leprae_Br4923 PALDLDALIGGFKPLFRALDPDKINTIASAIVAAFQGQGGTINDILDQTA
. *: : . . :: :: : :. . :
Mb3527c|M.bovis_AF2122/97 SLSRALNRRDEALQGLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDA
Rv3497c|M.tuberculosis_H37Rv SLSRALNRRDEALQGLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDA
MMAR_0179|M.marinum_M ALSSVISQRRDQLGTLLKSTQNVTDILRRQQSDLGSMIRQGQDLIGEFVA
MUL_4917|M.ulcerans_Agy99 ALSSVISQRRDQLGTLLKSTQNVTDILRRQQSDLGSMIRQGQDLIGEFVA
MAB_1697|M.abscessus_ATCC_1997 ALSAVIAQRREQLGTLLTSTENVTSMLRRQQSDIGTFIRQGQELVGEFVA
MSMEG_1145|M.smegmatis_MC2_155 TLSTIIAQRRDQLGELLKTTELISNTLYRQKSTIGSLMNQSNSLLAEFVA
TH_2869|M.thermoresistible__bu TLSSIIAQRRDQLGELLKTTEMVSTTLRRQQANIGNLVHQGNSLLGEFVA
Mflv_0008|M.gilvum_PYR-GCK TLSTIIADRRDQLGSLLETTEVVSNTLRRQQANIGSLVRQGNDLVGEFVL
Mvan_0961|M.vanbaalenii_PYR-1 TLSTILAQRRDQLGALLETTDVVSTTLKRQQSNIASMVRQGNDLVGEFVV
MAV_2386|M.avium_104 TLSSIIATRRDQLGQLLRSTEQVTNTLRRQQAGIGALVDQGQDLLGQFVA
MLBr_02590|M.leprae_Br4923 QLTTAIGERDQAIGEVVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKD
*: : * : : :: . : .: . : : : *. :
Mb3527c|M.bovis_AF2122/97 RRAALSALISGIDDVAAQISGFVADNRKEFGPALSKLNLVLANLNERRDY
Rv3497c|M.tuberculosis_H37Rv RRAALSALISGIDDVAAQISGFVADNRKEFGPALSKLNLVLANLNERRDY
MMAR_0179|M.marinum_M HSAAFHAMMQALTQVVGSLRTIVVDDRAALEDVVQTMEQLSAKLAEQDAL
MUL_4917|M.ulcerans_Agy99 HSAAFHAMMQALTQVVGSLRTIVVDDRAALEDVVQTMEQLSAKLAEQDAL
MAB_1697|M.abscessus_ATCC_1997 RSAAFHAMMRSLQSIVASLRTIVVGDHRALDGVIHTLEELSGKLADQDAL
MSMEG_1145|M.smegmatis_MC2_155 RRATFHAMMDALTNLVQTLSGIVIDDRPELEKLVEDLRQLSSLLSKNDGM
TH_2869|M.thermoresistible__bu RRATFHAMMDALTVLVQRLSDIVIDDRPELEELLSNLRELSGLLADNDGM
Mflv_0008|M.gilvum_PYR-GCK RRASFQAMMNAITNLVQTLGDIVIEDRPELEALLVNVRELSDMLGQHDDL
Mvan_0961|M.vanbaalenii_PYR-1 RRASFHAMLAAITDLVQTLSDIVIGDRPELEALLVNVRELSDMLGQHDDL
MAV_2386|M.avium_104 RRAVFHAMMRSLSSLVDTLSRVVVNDRSGVDALLKDIRDFTGLVSAHDDL
MLBr_02590|M.leprae_Br4923 HGDQLAGSFAHISNAAGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQ
: : . : : . : .: :: . : : . : .
Mb3527c|M.bovis_AF2122/97 ITEALKRLPTYATTLGEVVG-SGPGFNVNVYSVLPGPLVATVFDLVFQPG
Rv3497c|M.tuberculosis_H37Rv ITEALKRLPTYATTLGEVVG-SGPGFNVNVYSVLPGPLVATVFDLVFQPG
MMAR_0179|M.marinum_M FRNLLEIAPVPVRELANASG-YGNALELNAA---AGPLVDSWMCAISGRA
MUL_4917|M.ulcerans_Agy99 FRNLLEIAPVPVRELANASG-YGNALEINAA---AGPLVDSWMCAISGRA
MAB_1697|M.abscessus_ATCC_1997 LRNLLQIAPVPIREIANATG-FGNSIEGNPG---GGALIDSWMCAISGRA
MSMEG_1145|M.smegmatis_MC2_155 LRSILQTAPIALRNIANMTG-TGNAIDFNSS---SGLLVDSWMCAISGRA
TH_2869|M.thermoresistible__bu LRSILQTTPIAVRNLANITG-TGNAIDFNAP---GGLLVDSWMCAISGRA
Mflv_0008|M.gilvum_PYR-GCK LRSILQSGPPALRGLANATG-MGNAVEFNAA---NGLLVDSWMCAISGRA
Mvan_0961|M.vanbaalenii_PYR-1 VRNILQSGPLALRGLANATG-SGNAVDFNAA---NGLLVDSWMCAISGRA
MAV_2386|M.avium_104 LHSLLQVSPIFFREAANLTG-DGNAINFNAP---NVPLIDSWMCAISGRA
MLBr_02590|M.leprae_Br4923 LEDYLHKLPTVLNQIGRTIGSYGDFVNFYSC----DITLKINGLQPGGPV
. . *. * .. * * .: :
Mb3527c|M.bovis_AF2122/97 KLPDSLADYLRGFIQERWIIRPKSP
Rv3497c|M.tuberculosis_H37Rv KLPDSLADYLRGFIQERWIIRPKSP
MMAR_0179|M.marinum_M KQFG-LIQYFKDCA-----------
MUL_4917|M.ulcerans_Agy99 KQFG-LIQYFKDCA-----------
MAB_1697|M.abscessus_ATCC_1997 KQFG-MIEYFKDCQ-----------
MSMEG_1145|M.smegmatis_MC2_155 KQFG-MIQYFQDCK-----------
TH_2869|M.thermoresistible__bu KQFG-MIEYFQDCK-----------
Mflv_0008|M.gilvum_PYR-GCK KQFG-MIQYFQDCK-----------
Mvan_0961|M.vanbaalenii_PYR-1 KQFG-MIEYLKDCK-----------
MAV_2386|M.avium_104 KQFG-MIQYFKDCK-----------
MLBr_02590|M.leprae_Br4923 RTVRLFQQPTGRCTPQ---------
: : :