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MAERRKWPRRPLESYHSAWLGFAAVAVVAVLIGAMLLIKGADVGYRKYTAQFLQAAALQPGNPVTVAGIP VGEVTGMELAGDHVVADFTVRNDVALGEDSRAVIKVTTILGSRYLSLEPEGPGSLPDRRFDLAHTEVPYD LQEALTDVATTFEQVDSDKFAESLAILGRQLQGLPEVVPQALQNTHTLSTILAQRRDQLGALLETTDVVS TTLKRQQSNIASMVRQGNDLVGEFVVRRASFHAMLAAITDLVQTLSDIVIGDRPELEALLVNVRELSDML GQHDDLVRNILQSGPLALRGLANATGSGNAVDFNAANGLLVDSWMCAISGRAKQFGMIEYLKDCK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0961 | - | - | 100% (345) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_5200 | - | 1e-29 | 30.11% (269) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4397 | - | 3e-28 | 28.07% (285) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 3e-28 | 27.88% (269) | MCE-family protein MCE4C |
| M. gilvum PYR-GCK | Mflv_0008 | - | 1e-164 | 84.06% (345) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3497c | mce4C | 3e-28 | 27.88% (269) | MCE-family protein MCE4C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 2e-22 | 26.61% (327) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1008c | - | 1e-129 | 62.64% (348) | putative MCE family protein |
| M. marinum M | MMAR_3866 | mce5C | 1e-121 | 64.50% (338) | Mce family protein, Mce5C |
| M. avium 104 | MAV_0104 | - | 1e-122 | 63.22% (348) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_1145 | - | 1e-138 | 70.81% (346) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2869 | - | 1e-139 | 72.75% (334) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3798 | mce5C | 1e-120 | 64.20% (338) | Mce family protein, Mce5C |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0961|M.vanbaalenii_PYR-1 -----MAERRK-WPRRPLESYHSAWLGFAAVAVVAVLIGA--MLLIKGAD
Mflv_0008|M.gilvum_PYR-GCK -----MAEQTK-RRRRRLESYHKAWLGTVAVVVVAVLVGA--LLLIKAAD
MSMEG_1145|M.smegmatis_MC2_155 -----MAEARKARRRKPLESYNRLWLGVVAVAVVSVLIGA--MLLVRVAD
TH_2869|M.thermoresistible__bu -----------------LETYSRTTLGVIAVAVVAVLVGA--LLVVKAAG
MMAR_3866|M.marinum_M MADSSLRQRLSALQRRPLESYNKTWLGFAAVAVVAVVIAA--MLVVHLAG
MUL_3798|M.ulcerans_Agy99 MADSSLRHRLSALQRRPLESYNKTWLRFAAVAVVAVVIAA--MLVVHLAG
MAB_1008c|M.abscessus_ATCC_199 ---MAEQSRWQKIKSRPVETYNKTWLGFIAIAVIGALVGG--MLLVKAIG
MAV_0104|M.avium_104 ---MADTRKLRWLRRRPLESYNRTWLGLAGLVVVAVLVAV--SLGIKLLG
Mb3527c|M.bovis_AF2122/97 ------MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFG--YSGLPFWP
Rv3497c|M.tuberculosis_H37Rv ------MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFG--YSGLPFWP
MLBr_02591|M.leprae_Br4923 --------------MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPIL
: : : :
Mvan_0961|M.vanbaalenii_PYR-1 VGYRKYTAQFLQAAALQPGNPVTVAGIPVGEVTGMELAGDHVVADFTVRN
Mflv_0008|M.gilvum_PYR-GCK VGYRTFTAQFLQAAALQPGNPVSVAGIPVGEVTDMKLAGDHVEARFTVRN
MSMEG_1145|M.smegmatis_MC2_155 IGYTQYTARFLQAAALKAGNPVTVAGIPVGEVKSMRLAGDHVEAKIKVRN
TH_2869|M.thermoresistible__bu IGYKEYTARFLQAAALQPGNPITVAGIPVGEVLSMKLNGDHVEARLKVRG
MMAR_3866|M.marinum_M AGYRRYTAEFLQAAALRAGNPIAIAGIPVGTVTSMKLVGDHVEAGLRIRD
MUL_3798|M.ulcerans_Agy99 AGYRRYTAEFLQAAALRAGNPIAIAGIPVGTVTSMKLVGDHVEAGLRIRD
MAB_1008c|M.abscessus_ATCC_199 FGYTTYTAEFAQAASLRAGQPITVAGIPMGTVTSMKLVGDHVEAKLSVSD
MAV_0104|M.avium_104 VGYTHYTAEFLQAATLRPGNPITVAGIEVGHVTSMKLAGDHVEAGLSVRD
Mb3527c|M.bovis_AF2122/97 QG-KTYDAYFTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDR
Rv3497c|M.tuberculosis_H37Rv QG-KTYDAYFTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDR
MLBr_02591|M.leprae_Br4923 FARPSYYGQFTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-
. : . * ::. : *: : ::*: :* * : : *: . : :
Mvan_0961|M.vanbaalenii_PYR-1 DVALGEDSRAVIKVTTILGSRYLSLEPEGPGSL-PDRRFDLAHTEVPYDL
Mflv_0008|M.gilvum_PYR-GCK DVDLGEDSRAVIKVTTILGSRYLSLEPEGTGAL-PDRHFDLSHTEVPYDL
MSMEG_1145|M.smegmatis_MC2_155 DVGLGKDSRAKIMVTTILGSRYLSLEPAGDGTL-PDRTFDLSHTDVPYDL
TH_2869|M.thermoresistible__bu DIRLGEHSRAVIKITTILGSRYLALYPDGPGTL-PDNTFDLKHTEVPYDL
MMAR_3866|M.marinum_M DVVLGKDSTATIRVTTILGSRYLAIEPDGAASL-PDHTFDLAHTAVPYDL
MUL_3798|M.ulcerans_Agy99 DVVLGKDSTATIRVTTILGSRYLAIEPDGAASL-PDHTFDLAHTAVPYDL
MAB_1008c|M.abscessus_ATCC_199 DVKLGKDTKAAIRVTTILGSRYLDLQPEGPGSL-PNKTIDLAHTEVPYDL
MAV_0104|M.avium_104 NVPLGKDTRALIKVMTILGSRYLELVPDGPGSL-PANTIPLAHTEVPYDL
Mb3527c|M.bovis_AF2122/97 SIVVGDQSLAAIRTDTILGERSIAVSPAGSG---KSTTIPLSRTTTPYTL
Rv3497c|M.tuberculosis_H37Rv SIVVGDQSLAAIRTDTILGERSIAVSPAGSG---KSTTIPLSRTTTPYTL
MLBr_02591|M.leprae_Br4923 TNRIGTASRLGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQS
:* : * *:**.: : : . * : * :: .**
Mvan_0961|M.vanbaalenii_PYR-1 QEALTDVATTFEQVDSDKFAESLAILGRQLQGLPEVVPQALQNTHTLSTI
Mflv_0008|M.gilvum_PYR-GCK QEALTDVTTTFEQVDSDKFAETLSILGRQLQGMPEILPQALENTHTLSTI
MSMEG_1145|M.smegmatis_MC2_155 QEALTDVTTTFEKVDSDKFAETLQILGSQLETLPPVIPQALENTHTLSTI
TH_2869|M.thermoresistible__bu QEALADVATTYEQVDSDQFAESLAILGRQLETLPPVVPQALENTHTLSSI
MMAR_3866|M.marinum_M QAALKDATTTFEQVDSDRFAQSLTVLGRQLDKLPPVVPHAVANIDSLSSI
MUL_3798|M.ulcerans_Agy99 QAALKDATTTFEQVDSDRFAQSLTVLGRQLDKLPPVVPQAVANIDSLSSI
MAB_1008c|M.abscessus_ATCC_199 QATLRDATNTFDQVDFDKVAQSLSILGKQLDGLPEVVPQAMQNIQTLSQI
MAV_0104|M.avium_104 QSLLEDATTTFEQVDSDQFAQSLAVLGKQLGGVPPLVPQAVANLQTLSTI
Mb3527c|M.bovis_AF2122/97 NGVLQDLGRNANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRA
Rv3497c|M.tuberculosis_H37Rv NGVLQDLGRNANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRA
MLBr_02591|M.leprae_Br4923 YDAFFDATKVASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDT
: * . : . ::* :. : : *: . .:*
Mvan_0961|M.vanbaalenii_PYR-1 LAQRRDQLGALLETTDVVSTTLKRQQSNIASMVRQGNDLVGEFVVRRASF
Mflv_0008|M.gilvum_PYR-GCK IADRRDQLGSLLETTEVVSNTLRRQQANIGSLVRQGNDLVGEFVLRRASF
MSMEG_1145|M.smegmatis_MC2_155 IAQRRDQLGELLKTTELISNTLYRQKSTIGSLMNQSNSLLAEFVARRATF
TH_2869|M.thermoresistible__bu IAQRRDQLGELLKTTEMVSTTLRRQQANIGNLVHQGNSLLGEFVARRATF
MMAR_3866|M.marinum_M IATRRDQLGQLLESTEQVTNTLRRQLSTIGGLVNQGQDLMGQFVARRAVF
MUL_3798|M.ulcerans_Agy99 IATRRDQLGQLLESTEQVTNTLRRQLSTIGGLVNQGQDLMGQFVARRAVF
MAB_1008c|M.abscessus_ATCC_199 IAERRDQLGTLLKSSEKVTNTLRHQQQGIGTLINQGQNLIGEFVVRRGTF
MAV_0104|M.avium_104 TADRRGQLGALLKSTQRVVNTLRNQQSNIGHLMDQGQDLLGHLVARQATF
Mb3527c|M.bovis_AF2122/97 LNRRDEALQGLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAAL
Rv3497c|M.tuberculosis_H37Rv LNRRDEALQGLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAAL
MLBr_02591|M.leprae_Br4923 IGARDKEIKHLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAV
* : *: :. : ..* : : :: : : *.. : * .
Mvan_0961|M.vanbaalenii_PYR-1 HAMLAAITDLVQTLSDIVIGDRPELEALLVNVRELSDMLGQHDDLVRNIL
Mflv_0008|M.gilvum_PYR-GCK QAMMNAITNLVQTLGDIVIEDRPELEALLVNVRELSDMLGQHDDLLRSIL
MSMEG_1145|M.smegmatis_MC2_155 HAMMDALTNLVQTLSGIVIDDRPELEKLVEDLRQLSSLLSKNDGMLRSIL
TH_2869|M.thermoresistible__bu HAMMDALTVLVQRLSDIVIDDRPELEELLSNLRELSGLLADNDGMLRSIL
MMAR_3866|M.marinum_M HAMMRSLDGFVGTLR-QIIGDRPGVDALLKDMREFTGLLAQHDDLLSNLL
MUL_3798|M.ulcerans_Agy99 HAMMRSLDGFVGTLR-QIIGDRPGVDALLKDMREFTGLLAQHDDLLSNLL
MAB_1008c|M.abscessus_ATCC_199 HAMMQSLTNLVQQLSKITIKDRPQLDEMLRTLHQLTDMLGQHDDLLRNIL
MAV_0104|M.avium_104 HAMFAALTELVDQLDKIVVNNRPMLDELFANLHQLTNMVGQHDDLVRNIL
Mb3527c|M.bovis_AF2122/97 SALISGIDDVAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEAL
Rv3497c|M.tuberculosis_H37Rv SALISGIDDVAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEAL
MLBr_02591|M.leprae_Br4923 DALLGNVAAFAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTL
*:: : .. : : . . :. . : .. . : . *
Mvan_0961|M.vanbaalenii_PYR-1 QSGPLALRGLANATGSG---NAVDFNAANG-LLVDSWMCAISGR------
Mflv_0008|M.gilvum_PYR-GCK QSGPPALRGLANATGMG---NAVEFNAANG-LLVDSWMCAISGR------
MSMEG_1145|M.smegmatis_MC2_155 QTAPIALRNIANMTGTG---NAIDFNSSSG-LLVDSWMCAISGR------
TH_2869|M.thermoresistible__bu QTTPIAVRNLANITGTG---NAIDFNAPGG-LLVDSWMCAISGR------
MMAR_3866|M.marinum_M QISPIFFREATNITGDG---NAVNFNAPNGLLLVDSWMCAISGR------
MUL_3798|M.ulcerans_Agy99 QISPIFFREATNITGDG---NAVNFNAPNGLLLVDSWMRAISGR------
MAB_1008c|M.abscessus_ATCC_199 QITPVTLRGVANATGTG---NAIEFNAPNG-LAVDSWMCAISGR------
MAV_0104|M.avium_104 QVAPVTLRGLTNATGYG---PVVEFNLPNG-LAIDSWMCAISGR------
Mb3527c|M.bovis_AF2122/97 KRLPTYATTLGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPG------
Rv3497c|M.tuberculosis_H37Rv KRLPTYATTLGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPG------
MLBr_02591|M.leprae_Br4923 IQVAAFLPSLNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPEN
. : * * . .. : .:.
Mvan_0961|M.vanbaalenii_PYR-1 -AKQFGMIEY-LKDCK----------------------------------
Mflv_0008|M.gilvum_PYR-GCK -AKQFGMIQY-FQDCK----------------------------------
MSMEG_1145|M.smegmatis_MC2_155 -AKQFGMIQY-FQDCK----------------------------------
TH_2869|M.thermoresistible__bu -AKQFGMIEY-FQDCK----------------------------------
MMAR_3866|M.marinum_M -AEQFGMIPY-FKDCK----------------------------------
MUL_3798|M.ulcerans_Agy99 -AEQFGMIPY-FKDCK----------------------------------
MAB_1008c|M.abscessus_ATCC_199 -AKQFGMIQY-FKDCK----------------------------------
MAV_0104|M.avium_104 -AKEFNMIQY-FKDCK----------------------------------
Mb3527c|M.bovis_AF2122/97 -KLPDSLADY-LRGFIQERWIIRPKSP-----------------------
Rv3497c|M.tuberculosis_H37Rv -KLPDSLADY-LRGFIQERWIIRPKSP-----------------------
MLBr_02591|M.leprae_Br4923 FWRSAGLPEFRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCS
.: : : .
Mvan_0961|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0008|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
TH_2869|M.thermoresistible__bu --------------------------------------------------
MMAR_3866|M.marinum_M --------------------------------------------------
MUL_3798|M.ulcerans_Agy99 --------------------------------------------------
MAB_1008c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_0104|M.avium_104 --------------------------------------------------
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02591|M.leprae_Br4923 YTPAHPGGNNTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSP
Mvan_0961|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0008|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
TH_2869|M.thermoresistible__bu --------------------------------------------------
MMAR_3866|M.marinum_M --------------------------------------------------
MUL_3798|M.ulcerans_Agy99 --------------------------------------------------
MAB_1008c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_0104|M.avium_104 --------------------------------------------------
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02591|M.leprae_Br4923 PNPDGLPLLPGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAP
Mvan_0961|M.vanbaalenii_PYR-1 -----------------------------------
Mflv_0008|M.gilvum_PYR-GCK -----------------------------------
MSMEG_1145|M.smegmatis_MC2_155 -----------------------------------
TH_2869|M.thermoresistible__bu -----------------------------------
MMAR_3866|M.marinum_M -----------------------------------
MUL_3798|M.ulcerans_Agy99 -----------------------------------
MAB_1008c|M.abscessus_ATCC_199 -----------------------------------
MAV_0104|M.avium_104 -----------------------------------
Mb3527c|M.bovis_AF2122/97 -----------------------------------
Rv3497c|M.tuberculosis_H37Rv -----------------------------------
MLBr_02591|M.leprae_Br4923 AQDSSAPHEPREQLSAPLINPGGTGGSGGAGGSRN