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RQRLSALTKRPLESYNKTWLGFVAVAVVAAVIAVMLVVHALGAGYRHYTAEFAQAASLRAGNPIVVAGIP VGTVTSMKLVGDHVEAGLKVRDNISFGKDSRAQIRVTTILGSRYLALEPNGPARLPGNTFDLAHTEVPYD LQAALQDATTTFEQVDSDRFAQSLAVLGKQLEGLPAVVPQAITNIDTLSSIIATRRDQLGQLLRSTEQVT NTLRRQQAGIGALVDQGQDLLGQFVARRAVFHAMMRSLSSLVDTLSRVVVNDRSGVDALLKDIRDFTGLV SAHDDLLHSLLQVSPIFFREAANLTGDGNAINFNAPNVPLIDSWMCAISGRAKQFGMIQYFKDCK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2386 | - | - | 100% (346) | virulence factor Mce family protein |
| M. avium 104 | MAV_0104 | - | e-126 | 64.24% (344) | virulence factor Mce family protein |
| M. avium 104 | MAV_0659 | - | 9e-29 | 28.09% (299) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 9e-27 | 25.32% (316) | MCE-family protein MCE4C |
| M. gilvum PYR-GCK | Mflv_0008 | - | 1e-120 | 62.02% (337) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3497c | mce4C | 1e-26 | 25.32% (316) | MCE-family protein MCE4C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 6e-25 | 27.59% (290) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1008c | - | 1e-132 | 65.51% (345) | putative MCE family protein |
| M. marinum M | MMAR_3866 | mce5C | 1e-155 | 79.25% (347) | Mce family protein, Mce5C |
| M. smegmatis MC2 155 | MSMEG_1145 | - | 1e-121 | 61.76% (340) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2869 | - | 1e-123 | 65.57% (334) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3798 | mce5C | 1e-153 | 78.67% (347) | Mce family protein, Mce5C |
| M. vanbaalenii PYR-1 | Mvan_0961 | - | 1e-121 | 61.42% (337) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3866|M.marinum_M MADSSLRQRLSALQRRPLESYNKTWLGFAAVAVVAVVIAAMLVVHLAGAG
MUL_3798|M.ulcerans_Agy99 MADSSLRHRLSALQRRPLESYNKTWLRFAAVAVVAVVIAAMLVVHLAGAG
MAV_2386|M.avium_104 -----MRQRLSALTKRPLESYNKTWLGFVAVAVVAAVIAVMLVVHALGAG
MAB_1008c|M.abscessus_ATCC_199 MAE---QSRWQKIKSRPVETYNKTWLGFIAIAVIGALVGGMLLVKAIGFG
Mflv_0008|M.gilvum_PYR-GCK -----MAEQTK-RRRRRLESYHKAWLGTVAVVVVAVLVGALLLIKAADVG
Mvan_0961|M.vanbaalenii_PYR-1 -----MAERRK-WPRRPLESYHSAWLGFAAVAVVAVLIGAMLLIKGADVG
MSMEG_1145|M.smegmatis_MC2_155 -----MAEARKARRRKPLESYNRLWLGVVAVAVVSVLIGAMLLVRVADIG
TH_2869|M.thermoresistible__bu -----------------LETYSRTTLGVIAVAVVAVLVGALLVVKAAGIG
Mb3527c|M.bovis_AF2122/97 ------MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQG
Rv3497c|M.tuberculosis_H37Rv ------MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQG
MLBr_02591|M.leprae_Br4923 -----------MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFAR
: : : : : :
MMAR_3866|M.marinum_M YRRYTAEFLQAAALRAGNPIAIAGIPVGTVTSMKLVGDHVEAGLRIRDDV
MUL_3798|M.ulcerans_Agy99 YRRYTAEFLQAAALRAGNPIAIAGIPVGTVTSMKLVGDHVEAGLRIRDDV
MAV_2386|M.avium_104 YRHYTAEFAQAASLRAGNPIVVAGIPVGTVTSMKLVGDHVEAGLKVRDNI
MAB_1008c|M.abscessus_ATCC_199 YTTYTAEFAQAASLRAGQPITVAGIPMGTVTSMKLVGDHVEAKLSVSDDV
Mflv_0008|M.gilvum_PYR-GCK YRTFTAQFLQAAALQPGNPVSVAGIPVGEVTDMKLAGDHVEARFTVRNDV
Mvan_0961|M.vanbaalenii_PYR-1 YRKYTAQFLQAAALQPGNPVTVAGIPVGEVTGMELAGDHVVADFTVRNDV
MSMEG_1145|M.smegmatis_MC2_155 YTQYTARFLQAAALKAGNPVTVAGIPVGEVKSMRLAGDHVEAKIKVRNDV
TH_2869|M.thermoresistible__bu YKEYTARFLQAAALQPGNPITVAGIPVGEVLSMKLNGDHVEARLKVRGDI
Mb3527c|M.bovis_AF2122/97 -KTYDAYFTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSI
Rv3497c|M.tuberculosis_H37Rv -KTYDAYFTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSI
MLBr_02591|M.leprae_Br4923 -PSYYGQFTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TN
: . * ::..: *: : ::*: :* * : : *: . : :
MMAR_3866|M.marinum_M VLGKDSTATIRVTTILGSRYLAIEPDGAASL-PDHTFDLAHTAVPYDLQA
MUL_3798|M.ulcerans_Agy99 VLGKDSTATIRVTTILGSRYLAIEPDGAASL-PDHTFDLAHTAVPYDLQA
MAV_2386|M.avium_104 SFGKDSRAQIRVTTILGSRYLALEPNGPARL-PGNTFDLAHTEVPYDLQA
MAB_1008c|M.abscessus_ATCC_199 KLGKDTKAAIRVTTILGSRYLDLQPEGPGSL-PNKTIDLAHTEVPYDLQA
Mflv_0008|M.gilvum_PYR-GCK DLGEDSRAVIKVTTILGSRYLSLEPEGTGAL-PDRHFDLSHTEVPYDLQE
Mvan_0961|M.vanbaalenii_PYR-1 ALGEDSRAVIKVTTILGSRYLSLEPEGPGSL-PDRRFDLAHTEVPYDLQE
MSMEG_1145|M.smegmatis_MC2_155 GLGKDSRAKIMVTTILGSRYLSLEPAGDGTL-PDRTFDLSHTDVPYDLQE
TH_2869|M.thermoresistible__bu RLGEHSRAVIKITTILGSRYLALYPDGPGTL-PDNTFDLKHTEVPYDLQE
Mb3527c|M.bovis_AF2122/97 VVGDQSLAAIRTDTILGERSIAVSPAGSG---KSTTIPLSRTTTPYTLNG
Rv3497c|M.tuberculosis_H37Rv VVGDQSLAAIRTDTILGERSIAVSPAGSG---KSTTIPLSRTTTPYTLNG
MLBr_02591|M.leprae_Br4923 RIGTASRLGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYD
.* : * *:**.: : : . * . : * :: .**
MMAR_3866|M.marinum_M ALKDATTTFEQVDSDRFAQSLTVLGRQLDKLPPVVPHAVANIDSLSSIIA
MUL_3798|M.ulcerans_Agy99 ALKDATTTFEQVDSDRFAQSLTVLGRQLDKLPPVVPQAVANIDSLSSIIA
MAV_2386|M.avium_104 ALQDATTTFEQVDSDRFAQSLAVLGKQLEGLPAVVPQAITNIDTLSSIIA
MAB_1008c|M.abscessus_ATCC_199 TLRDATNTFDQVDFDKVAQSLSILGKQLDGLPEVVPQAMQNIQTLSQIIA
Mflv_0008|M.gilvum_PYR-GCK ALTDVTTTFEQVDSDKFAETLSILGRQLQGMPEILPQALENTHTLSTIIA
Mvan_0961|M.vanbaalenii_PYR-1 ALTDVATTFEQVDSDKFAESLAILGRQLQGLPEVVPQALQNTHTLSTILA
MSMEG_1145|M.smegmatis_MC2_155 ALTDVTTTFEKVDSDKFAETLQILGSQLETLPPVIPQALENTHTLSTIIA
TH_2869|M.thermoresistible__bu ALADVATTYEQVDSDQFAESLAILGRQLETLPPVVPQALENTHTLSSIIA
Mb3527c|M.bovis_AF2122/97 VLQDLGRNANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALN
Rv3497c|M.tuberculosis_H37Rv VLQDLGRNANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALN
MLBr_02591|M.leprae_Br4923 AFFDATKVASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIG
.: * . : . ::* :. :. : *: . .:* :
MMAR_3866|M.marinum_M TRRDQLGQLLESTEQVTNTLRRQLSTIGGLVNQGQDLMGQFVARRAVFHA
MUL_3798|M.ulcerans_Agy99 TRRDQLGQLLESTEQVTNTLRRQLSTIGGLVNQGQDLMGQFVARRAVFHA
MAV_2386|M.avium_104 TRRDQLGQLLRSTEQVTNTLRRQQAGIGALVDQGQDLLGQFVARRAVFHA
MAB_1008c|M.abscessus_ATCC_199 ERRDQLGTLLKSSEKVTNTLRHQQQGIGTLINQGQNLIGEFVVRRGTFHA
Mflv_0008|M.gilvum_PYR-GCK DRRDQLGSLLETTEVVSNTLRRQQANIGSLVRQGNDLVGEFVLRRASFQA
Mvan_0961|M.vanbaalenii_PYR-1 QRRDQLGALLETTDVVSTTLKRQQSNIASMVRQGNDLVGEFVVRRASFHA
MSMEG_1145|M.smegmatis_MC2_155 QRRDQLGELLKTTELISNTLYRQKSTIGSLMNQSNSLLAEFVARRATFHA
TH_2869|M.thermoresistible__bu QRRDQLGELLKTTEMVSTTLRRQQANIGNLVHQGNSLLGEFVARRATFHA
Mb3527c|M.bovis_AF2122/97 RRDEALQGLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSA
Rv3497c|M.tuberculosis_H37Rv RRDEALQGLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSA
MLBr_02591|M.leprae_Br4923 ARDKEIKHLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDA
* . : *: :. ::..* : : :: : : *.. : * . *
MMAR_3866|M.marinum_M MMRSLDGFVGTL-RQIIGDRPGVDALLKDMREFTGLLAQHDDLLSNLLQI
MUL_3798|M.ulcerans_Agy99 MMRSLDGFVGTL-RQIIGDRPGVDALLKDMREFTGLLAQHDDLLSNLLQI
MAV_2386|M.avium_104 MMRSLSSLVDTLSRVVVNDRSGVDALLKDIRDFTGLVSAHDDLLHSLLQV
MAB_1008c|M.abscessus_ATCC_199 MMQSLTNLVQQLSKITIKDRPQLDEMLRTLHQLTDMLGQHDDLLRNILQI
Mflv_0008|M.gilvum_PYR-GCK MMNAITNLVQTLGDIVIEDRPELEALLVNVRELSDMLGQHDDLLRSILQS
Mvan_0961|M.vanbaalenii_PYR-1 MLAAITDLVQTLSDIVIGDRPELEALLVNVRELSDMLGQHDDLVRNILQS
MSMEG_1145|M.smegmatis_MC2_155 MMDALTNLVQTLSGIVIDDRPELEKLVEDLRQLSSLLSKNDGMLRSILQT
TH_2869|M.thermoresistible__bu MMDALTVLVQRLSDIVIDDRPELEELLSNLRELSGLLADNDGMLRSILQT
Mb3527c|M.bovis_AF2122/97 LISGIDDVAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKR
Rv3497c|M.tuberculosis_H37Rv LISGIDDVAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKR
MLBr_02591|M.leprae_Br4923 LLGNVAAFAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQ
:: : .. : : . : :. . : . . : . *
MMAR_3866|M.marinum_M SPIFFREATNITGDGNAVNFNAPNG--LLLVDSWMCAISGR---------
MUL_3798|M.ulcerans_Agy99 SPIFFREATNITGDGNAVNFNAPNG--LLLVDSWMRAISGR---------
MAV_2386|M.avium_104 SPIFFREAANLTGDGNAINFNAPN---VPLIDSWMCAISGR---------
MAB_1008c|M.abscessus_ATCC_199 TPVTLRGVANATGTGNAIEFNAPN---GLAVDSWMCAISGR---------
Mflv_0008|M.gilvum_PYR-GCK GPPALRGLANATGMGNAVEFNAAN---GLLVDSWMCAISGR---------
Mvan_0961|M.vanbaalenii_PYR-1 GPLALRGLANATGSGNAVDFNAAN---GLLVDSWMCAISGR---------
MSMEG_1145|M.smegmatis_MC2_155 APIALRNIANMTGTGNAIDFNSSS---GLLVDSWMCAISGR---------
TH_2869|M.thermoresistible__bu TPIAVRNLANITGTGNAIDFNAPG---GLLVDSWMCAISGR---------
Mb3527c|M.bovis_AF2122/97 LPTYATTLGEVVGSGPGFNVNVYS----VLPGPLVATVFDL---------
Rv3497c|M.tuberculosis_H37Rv LPTYATTLGEVVGSGPGFNVNVYS----VLPGPLVATVFDL---------
MLBr_02591|M.leprae_Br4923 VAAFLPSLNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFW
. : * * ... . . : :
MMAR_3866|M.marinum_M ----AEQFG-----MIPYFKDCK---------------------------
MUL_3798|M.ulcerans_Agy99 ----AEQFG-----MIPYFKDCK---------------------------
MAV_2386|M.avium_104 ----AKQFG-----MIQYFKDCK---------------------------
MAB_1008c|M.abscessus_ATCC_199 ----AKQFG-----MIQYFKDCK---------------------------
Mflv_0008|M.gilvum_PYR-GCK ----AKQFG-----MIQYFQDCK---------------------------
Mvan_0961|M.vanbaalenii_PYR-1 ----AKQFG-----MIEYLKDCK---------------------------
MSMEG_1145|M.smegmatis_MC2_155 ----AKQFG-----MIQYFQDCK---------------------------
TH_2869|M.thermoresistible__bu ----AKQFG-----MIEYFQDCK---------------------------
Mb3527c|M.bovis_AF2122/97 ----VFQPGKLPDSLADYLRGFIQERWIIRPKSP----------------
Rv3497c|M.tuberculosis_H37Rv ----VFQPGKLPDSLADYLRGFIQERWIIRPKSP----------------
MLBr_02591|M.leprae_Br4923 RSAGLPEFRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYT
: : ..
MMAR_3866|M.marinum_M --------------------------------------------------
MUL_3798|M.ulcerans_Agy99 --------------------------------------------------
MAV_2386|M.avium_104 --------------------------------------------------
MAB_1008c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0008|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
TH_2869|M.thermoresistible__bu --------------------------------------------------
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02591|M.leprae_Br4923 PAHPGGNNTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPN
MMAR_3866|M.marinum_M --------------------------------------------------
MUL_3798|M.ulcerans_Agy99 --------------------------------------------------
MAV_2386|M.avium_104 --------------------------------------------------
MAB_1008c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0008|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
TH_2869|M.thermoresistible__bu --------------------------------------------------
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02591|M.leprae_Br4923 PDGLPLLPGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPAQ
MMAR_3866|M.marinum_M ---------------------------------
MUL_3798|M.ulcerans_Agy99 ---------------------------------
MAV_2386|M.avium_104 ---------------------------------
MAB_1008c|M.abscessus_ATCC_199 ---------------------------------
Mflv_0008|M.gilvum_PYR-GCK ---------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 ---------------------------------
MSMEG_1145|M.smegmatis_MC2_155 ---------------------------------
TH_2869|M.thermoresistible__bu ---------------------------------
Mb3527c|M.bovis_AF2122/97 ---------------------------------
Rv3497c|M.tuberculosis_H37Rv ---------------------------------
MLBr_02591|M.leprae_Br4923 DSSAPHEPREQLSAPLINPGGTGGSGGAGGSRN