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AERSRWQKIKNRPIETYNKTWLGFIAIAVIASLIGAMLLIKALGLGYTSYTAEFVQAASLRPGQPITVAG IPVGNVTSMKLVGDHVEAGLKVRDDIRLGKDTKASIRVTTILGSRYLDLRPRGSAALPGKTIDLAHTEVP YDLQAALAGATNTFEQVDFDKVAQSLTVLGTQLQGLPDVVPRAMENIQSLSSVIADRRDQLGTLLKSTEK VTSTLRRQQSGIGVLINQGQDILEEIVTRRNTFHAMLQSFTNLVEQLSKVVVQDRAQLNAMLKTAHELSD MLGKHDDLLRSLYPIAPVLIRGIANSTGTGNAIDINLTNGLLVDSWMCAISGRAKQFGMIPYFKDCK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4514c | - | - | 100% (348) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1008c | - | e-156 | 75.86% (348) | putative MCE family protein |
| M. abscessus ATCC 19977 | MAB_4566c | - | e-120 | 59.08% (347) | putative Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0177 | mce1C | 7e-24 | 25.68% (292) | MCE-family protein MCE1C |
| M. gilvum PYR-GCK | Mflv_0008 | - | 1e-123 | 60.06% (348) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1968 | mce3C | 6e-29 | 26.81% (317) | MCE-family protein MCE3C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 1e-25 | 25.00% (312) | putative secreted protein |
| M. marinum M | MMAR_3866 | mce5C | 1e-121 | 63.29% (346) | Mce family protein, Mce5C |
| M. avium 104 | MAV_2386 | - | 1e-130 | 66.09% (345) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_1145 | - | 1e-119 | 59.47% (338) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2869 | - | 1e-117 | 61.98% (334) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4917 | mce6C | 1e-119 | 59.65% (347) | MCE-family protein Mce6C |
| M. vanbaalenii PYR-1 | Mvan_0961 | - | 1e-124 | 60.63% (348) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3866|M.marinum_M MADSSLRQRLSALQRRPLESYNKTWLGFAAVAVVAVVIAAMLVVHLAGAG
MAV_2386|M.avium_104 -----MRQRLSALTKRPLESYNKTWLGFVAVAVVAAVIAVMLVVHALGAG
MAB_4514c|M.abscessus_ATCC_199 ---MAERSRWQKIKNRPIETYNKTWLGFIAIAVIASLIGAMLLIKALGLG
Mflv_0008|M.gilvum_PYR-GCK -----MAEQTK-RRRRRLESYHKAWLGTVAVVVVAVLVGALLLIKAADVG
Mvan_0961|M.vanbaalenii_PYR-1 -----MAERRK-WPRRPLESYHSAWLGFAAVAVVAVLIGAMLLIKGADVG
MSMEG_1145|M.smegmatis_MC2_155 -----MAEARKARRRKPLESYNRLWLGVVAVAVVSVLIGAMLLVRVADIG
TH_2869|M.thermoresistible__bu -----------------LETYSRTTLGVIAVAVVAVLVGALLVVKAAGIG
MUL_4917|M.ulcerans_Agy99 ---MAERIKHLRPRLRPLASYNKTWLGFVGLSLAVVMIGALLLVKQGGIG
Mb0177|M.bovis_AF2122/97 --------------MRTLEPPNRMRIGLMGIVVALLVVAVGQSFTSVPML
MLBr_02591|M.leprae_Br4923 --------------MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPIL
Rv1968|M.tuberculosis_H37Rv --------------MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFF
: * .: : : .
MMAR_3866|M.marinum_M YR--RYTAEFLQAAALRAGNPIAIAGIPVGTVTSMKLVGDHVEAGLRIRD
MAV_2386|M.avium_104 YR--HYTAEFAQAASLRAGNPIVVAGIPVGTVTSMKLVGDHVEAGLKVRD
MAB_4514c|M.abscessus_ATCC_199 YT--SYTAEFVQAASLRPGQPITVAGIPVGNVTSMKLVGDHVEAGLKVRD
Mflv_0008|M.gilvum_PYR-GCK YR--TFTAQFLQAAALQPGNPVSVAGIPVGEVTDMKLAGDHVEARFTVRN
Mvan_0961|M.vanbaalenii_PYR-1 YR--KYTAQFLQAAALQPGNPVTVAGIPVGEVTGMELAGDHVVADFTVRN
MSMEG_1145|M.smegmatis_MC2_155 YT--QYTARFLQAAALKAGNPVTVAGIPVGEVKSMRLAGDHVEAKIKVRN
TH_2869|M.thermoresistible__bu YK--EYTARFLQAAALQPGNPITVAGIPVGEVLSMKLNGDHVEARLKVRG
MUL_4917|M.ulcerans_Agy99 YR--RYTAEFLQAASLQPDNVVSVAGVPVGNVISVRLAGNHVEARLRVKD
Mb0177|M.bovis_AF2122/97 FAKPSYYGQFTDSGGLHKGDRVRIAGLGVGTVEGLKIDGDHIVVKFSIGT
MLBr_02591|M.leprae_Br4923 FARPSYYGQFTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIGT
Rv1968|M.tuberculosis_H37Rv NQGTRVSAYFADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDT
. * ::..*. .: : ::* ** * : : * : : :
MMAR_3866|M.marinum_M DVVLGKDSTATIRVTTILGSRYLAIEPDGAASLPDH-TFDLAHTAVPYDL
MAV_2386|M.avium_104 NISFGKDSRAQIRVTTILGSRYLALEPNGPARLPGN-TFDLAHTEVPYDL
MAB_4514c|M.abscessus_ATCC_199 DIRLGKDTKASIRVTTILGSRYLDLRPRGSAALPGK-TIDLAHTEVPYDL
Mflv_0008|M.gilvum_PYR-GCK DVDLGEDSRAVIKVTTILGSRYLSLEPEGTGALPDR-HFDLSHTEVPYDL
Mvan_0961|M.vanbaalenii_PYR-1 DVALGEDSRAVIKVTTILGSRYLSLEPEGPGSLPDR-RFDLAHTEVPYDL
MSMEG_1145|M.smegmatis_MC2_155 DVGLGKDSRAKIMVTTILGSRYLSLEPAGDGTLPDR-TFDLSHTDVPYDL
TH_2869|M.thermoresistible__bu DIRLGEHSRAVIKITTILGSRYLALYPDGPGTLPDN-TFDLKHTEVPYDL
MUL_4917|M.ulcerans_Agy99 NIALGRDTRAAIKITTIFGSRYIDLHPTGAGVPPGQ-TIDLAHTEVPYDL
Mb0177|M.bovis_AF2122/97 NT-IGTESRLAIRTDTILGRKVLEIEPRGAQALPPGGVLPVGQSTTPYQI
MLBr_02591|M.leprae_Br4923 NR-IGTASRLGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQS
Rv1968|M.tuberculosis_H37Rv DVRLGNRTEVAIKTKGLLGSKFLDVTPRGDGRLDS--PIPIERTTSPYQL
: :* : * ::* : : : . * : : :: **:
MMAR_3866|M.marinum_M QAALKDATTTFEQVDSDRFAQSLTVLGRQLDKLPPVVPHAVANIDSLSSI
MAV_2386|M.avium_104 QAALQDATTTFEQVDSDRFAQSLAVLGKQLEGLPAVVPQAITNIDTLSSI
MAB_4514c|M.abscessus_ATCC_199 QAALAGATNTFEQVDFDKVAQSLTVLGTQLQGLPDVVPRAMENIQSLSSV
Mflv_0008|M.gilvum_PYR-GCK QEALTDVTTTFEQVDSDKFAETLSILGRQLQGMPEILPQALENTHTLSTI
Mvan_0961|M.vanbaalenii_PYR-1 QEALTDVATTFEQVDSDKFAESLAILGRQLQGLPEVVPQALQNTHTLSTI
MSMEG_1145|M.smegmatis_MC2_155 QEALTDVTTTFEKVDSDKFAETLQILGSQLETLPPVIPQALENTHTLSTI
TH_2869|M.thermoresistible__bu QEALADVATTYEQVDSDQFAESLAILGRQLETLPPVVPQALENTHTLSSI
MUL_4917|M.ulcerans_Agy99 QAALADSTRTFEQVDGDRIASSLTVLGQALNGLPDVFPQALENVRALSSV
Mb0177|M.bovis_AF2122/97 YDAFFDVTKAASGWDIETVKRSLNVLSETVDQTYPHLSAALDGVAKFSDT
MLBr_02591|M.leprae_Br4923 YDAFFDATKVASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDT
Rv1968|M.tuberculosis_H37Rv PDALGDLAATISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQT
*: . : . . . : . :* :. . . *: . ::
MMAR_3866|M.marinum_M IATRRDQLGQLLESTEQVTNTLRRQLSTIGGLVNQGQDLMGQFVARRAVF
MAV_2386|M.avium_104 IATRRDQLGQLLRSTEQVTNTLRRQQAGIGALVDQGQDLLGQFVARRAVF
MAB_4514c|M.abscessus_ATCC_199 IADRRDQLGTLLKSTEKVTSTLRRQQSGIGVLINQGQDILEEIVTRRNTF
Mflv_0008|M.gilvum_PYR-GCK IADRRDQLGSLLETTEVVSNTLRRQQANIGSLVRQGNDLVGEFVLRRASF
Mvan_0961|M.vanbaalenii_PYR-1 LAQRRDQLGALLETTDVVSTTLKRQQSNIASMVRQGNDLVGEFVVRRASF
MSMEG_1145|M.smegmatis_MC2_155 IAQRRDQLGELLKTTELISNTLYRQKSTIGSLMNQSNSLLAEFVARRATF
TH_2869|M.thermoresistible__bu IAQRRDQLGELLKTTEMVSTTLRRQQANIGNLVHQGNSLLGEFVARRATF
MUL_4917|M.ulcerans_Agy99 ISQRRDQLGTLLKSTQNVTDILRRQQSDLGSMIRQGQDLIGEFVAHSAAF
Mb0177|M.bovis_AF2122/97 IGKRDEQITHLLAQANQVASILGDRSDQVDRLLVNAKTLIAAFNERGRAV
MLBr_02591|M.leprae_Br4923 IGARDKEIKHLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAV
Rv1968|M.tuberculosis_H37Rv LDERDNQLRSLLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAAL
: * .:: *: : : * : : :: : : :: : : .
MMAR_3866|M.marinum_M HAMMRSLDGFVGTL-RQIIGDRPGVDALLKDMREFTGLLAQHDDLLSNLL
MAV_2386|M.avium_104 HAMMRSLSSLVDTLSRVVVNDRSGVDALLKDIRDFTGLVSAHDDLLHSLL
MAB_4514c|M.abscessus_ATCC_199 HAMLQSFTNLVEQLSKVVVQDRAQLNAMLKTAHELSDMLGKHDDLLRSLY
Mflv_0008|M.gilvum_PYR-GCK QAMMNAITNLVQTLGDIVIEDRPELEALLVNVRELSDMLGQHDDLLRSIL
Mvan_0961|M.vanbaalenii_PYR-1 HAMLAAITDLVQTLSDIVIGDRPELEALLVNVRELSDMLGQHDDLVRNIL
MSMEG_1145|M.smegmatis_MC2_155 HAMMDALTNLVQTLSGIVIDDRPELEKLVEDLRQLSSLLSKNDGMLRSIL
TH_2869|M.thermoresistible__bu HAMMDALTVLVQRLSDIVIDDRPELEELLSNLRELSGLLADNDGMLRSIL
MUL_4917|M.ulcerans_Agy99 HAMMQALTQVVGSLRTIVVDDRAALEDVVQTMEQLSAKLAEQDALFRNLL
Mb0177|M.bovis_AF2122/97 DALLGNISAFSAQVQNLINDN-PNLNHVLEQLRILTDLLVDRKEDLAETL
MLBr_02591|M.leprae_Br4923 DALLGNVAAFAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTL
Rv1968|M.tuberculosis_H37Rv DRIWANISAVAEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAI
. : . . : : : : : . . : .. . .
MMAR_3866|M.marinum_M QISPIFFREATNITGDGNAVNFNAPNG--LLLVDSWMCAISG--------
MAV_2386|M.avium_104 QVSPIFFREAANLTGDGNAINFNAPN---VPLIDSWMCAISG--------
MAB_4514c|M.abscessus_ATCC_199 PIAPVLIRGIANSTGTGNAIDINLTN---GLLVDSWMCAISG--------
Mflv_0008|M.gilvum_PYR-GCK QSGPPALRGLANATGMGNAVEFNAAN---GLLVDSWMCAISG--------
Mvan_0961|M.vanbaalenii_PYR-1 QSGPLALRGLANATGSGNAVDFNAAN---GLLVDSWMCAISG--------
MSMEG_1145|M.smegmatis_MC2_155 QTAPIALRNIANMTGTGNAIDFNSSS---GLLVDSWMCAISG--------
TH_2869|M.thermoresistible__bu QTTPIAVRNLANITGTGNAIDFNAPG---GLLVDSWMCAISG--------
MUL_4917|M.ulcerans_Agy99 EIAPVPVRELANASGYGNALEINAAA---GPLVDSWMCAISG--------
Mb0177|M.bovis_AF2122/97 TILGRFSASFGETFASGPYFKVLLANLVPGQILQPFVDAAFKKRGISPED
MLBr_02591|M.leprae_Br4923 IQVAAFLPSLNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPEN
Rv1968|M.tuberculosis_H37Rv PLINTYVMSLGESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDP--
: . * .. :::.:: *
MMAR_3866|M.marinum_M --------------------------------------------------
MAV_2386|M.avium_104 --------------------------------------------------
MAB_4514c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0008|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
TH_2869|M.thermoresistible__bu --------------------------------------------------
MUL_4917|M.ulcerans_Agy99 --------------------------------------------------
Mb0177|M.bovis_AF2122/97 FWRSAGLPAYRWPDPNGTRFPNGAPPPPPPVLEGTPEHPGPAVPPGSPCS
MLBr_02591|M.leprae_Br4923 FWRSAGLPEFRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCS
Rv1968|M.tuberculosis_H37Rv ----ATLLPSQLTDP-------------PTGQPGTP--------------
MMAR_3866|M.marinum_M ------------------------------RAEQFGMIPYFKDCK-----
MAV_2386|M.avium_104 ------------------------------RAKQFGMIQYFKDCK-----
MAB_4514c|M.abscessus_ATCC_199 ------------------------------RAKQFGMIPYFKDCK-----
Mflv_0008|M.gilvum_PYR-GCK ------------------------------RAKQFGMIQYFQDCK-----
Mvan_0961|M.vanbaalenii_PYR-1 ------------------------------RAKQFGMIEYLKDCK-----
MSMEG_1145|M.smegmatis_MC2_155 ------------------------------RAKQFGMIQYFQDCK-----
TH_2869|M.thermoresistible__bu ------------------------------RAKQFGMIEYFQDCK-----
MUL_4917|M.ulcerans_Agy99 ------------------------------RAKQFGLIQYFKDCA-----
Mb0177|M.bovis_AF2122/97 YTPPADG----------LPRPWDPLPCANLTQGPFGGPDFPAPLDVATSP
MLBr_02591|M.leprae_Br4923 YTPAHPGGNNTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSP
Rv1968|M.tuberculosis_H37Rv -----------------------PLPMPYPRTGQGGEPRLTLPDAITGNP
*
MMAR_3866|M.marinum_M --------------------------------------------------
MAV_2386|M.avium_104 --------------------------------------------------
MAB_4514c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0008|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 --------------------------------------------------
TH_2869|M.thermoresistible__bu --------------------------------------------------
MUL_4917|M.ulcerans_Agy99 --------------------------------------------------
Mb0177|M.bovis_AF2122/97 PNPDGPPPAPGLPIAGRPGEVPPNVPGTPVPIPQEAPPGARTLPLGPAPG
MLBr_02591|M.leprae_Br4923 PNPDGLPLLPGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPA--
Rv1968|M.tuberculosis_H37Rv GDPR-YPYRP---------EPPAPPPGGPPPGPPAQQPGDQP--------
MMAR_3866|M.marinum_M -----------------------------------------
MAV_2386|M.avium_104 -----------------------------------------
MAB_4514c|M.abscessus_ATCC_199 -----------------------------------------
Mflv_0008|M.gilvum_PYR-GCK -----------------------------------------
Mvan_0961|M.vanbaalenii_PYR-1 -----------------------------------------
MSMEG_1145|M.smegmatis_MC2_155 -----------------------------------------
TH_2869|M.thermoresistible__bu -----------------------------------------
MUL_4917|M.ulcerans_Agy99 -----------------------------------------
Mb0177|M.bovis_AF2122/97 PAPPPAAPGPPAPPGPGPQLPAPFINPGGTGGSGVTGGSEN
MLBr_02591|M.leprae_Br4923 -AP---AQDSSAPHEPREQLSAPLINPGGTGGSGGAGGSRN
Rv1968|M.tuberculosis_H37Rv -----------------------------------------