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MRTLTEFNRGRVGMMGAVVTVLVVGVAQSFTSVPMLFATPTYYAQFADTGGINTGDKVEIAGVNVGLVRS LAIRGNRVLIGFSLPGKTIGMQSRAAIRTDTILGRKNLEIEPRGSEPLKPNGFLPLAQTTTPYQIYDAFV DVTKAATGWDIDAVKRSLNVLSETFDQTAPHLSAALEGVKAFSDTVGRRGEQIEQLLANANRIARVLGDR SEQVNGLLVNAKTLLAAFKQRSQALRILLTNVSEASAQVSGLITDNPNLNHVLAQLRTVSEELVKRKNEL ADVAVLLGRYTAALTEAVGSGPFFKAMVVNLLPYQILQPWVDAAFKKRGIDPENFWRSAGLPEFRWPDPN GTRFPNGAPPAAPPVREGTPKHPGPAVPPGTPCSYTPAAGALPRPDTPLPCAGATVGPFGGPDFPAPLDV QPSPPNPDGPPPTPGILSAGRPGEPAPAVPGIPMPLPPNAPPGARTQPLEPFPDGTGGSNQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0591 | mce2C | - | 100% (481) | MCE-FAMILY PROTEIN MCE2C |
| M. tuberculosis H37Rv | Rv0171 | mce1C | 0.0 | 68.08% (473) | MCE-family protein MCE1C |
| M. tuberculosis H37Rv | Rv1968 | mce3C | 3e-58 | 34.08% (446) | MCE-family protein MCE3C |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0606 | mce2C | 0.0 | 99.58% (481) | MCE-family protein MCE2C |
| M. gilvum PYR-GCK | Mflv_0709 | - | 1e-170 | 63.08% (474) | virulence factor Mce family protein |
| M. leprae Br4923 | MLBr_02591 | mce1C | 0.0 | 64.24% (481) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 2e-46 | 33.23% (328) | MCE-family protein |
| M. marinum M | MMAR_0414 | mce1C | 0.0 | 66.95% (472) | MCE-family protein Mce1C |
| M. avium 104 | MAV_4549 | - | 0.0 | 77.02% (483) | mce-family protein mce2c |
| M. smegmatis MC2 155 | MSMEG_0136 | - | 1e-174 | 62.24% (474) | virulence factor Mce family protein, putative |
| M. thermoresistible (build 8) | TH_3066 | - | 1e-175 | 66.16% (464) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_1064 | mce1C | 0.0 | 66.31% (472) | MCE-family protein Mce1C |
| M. vanbaalenii PYR-1 | Mvan_0136 | - | 1e-178 | 65.68% (475) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0591|M.tuberculosis_H37Rv ----MRTLTEFNRGRVGMMGAVVTVLVVGVAQSFTSVPMLFATPTYYAQF
Mb0606|M.bovis_AF2122/97 ----MRTLTEFNRGRVGMMGAVVTVLVVGVAQSFTSVPMLFATPTYYAQF
MAV_4549|M.avium_104 ----MRTLTEFNRTRVGLMGALVTVLVVGVGQSFTSVPMLFATPTYYAQF
MMAR_0414|M.marinum_M ----MRTLEPPNRLRIGLMGIVVMLVVVGVGQSFTSVPMIFARPSYYGQF
MUL_1064|M.ulcerans_Agy99 ----MRTLEPPNRLRIGLMGIVVMLVVVGVGQSFTSVPMIFARPSYYGQF
MLBr_02591|M.leprae_Br4923 ----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQF
Mflv_0709|M.gilvum_PYR-GCK ----MRVLEGSNRVRGGLMGIILLVVVIGVGQSFASVPMLFATPTYYAEF
Mvan_0136|M.vanbaalenii_PYR-1 ----MRVLEGSNRIRGGMMGIIILVLVIGVGQSFASVPMLFATPTYYAQF
MSMEG_0136|M.smegmatis_MC2_155 ----MRTLQGSDRFRKGLMGVIVVALIIGVGSTLTSVPMLFAVPTYYGQF
TH_3066|M.thermoresistible__bu -------LEESDRLRNGLKGIIILLLVIGVGQSFASVPMLFATPTYYAQF
MAB_4151c|M.abscessus_ATCC_199 MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGYF
: : * *: * : ::: *. :.:*: * . *
Rv0591|M.tuberculosis_H37Rv ADTGGINTGDKVEIAGVNVGLVRSLAIRGNRVLIGFSLP-GKTIGMQSRA
Mb0606|M.bovis_AF2122/97 ADMGGINTGDKVEIAGVNVGLVRSLAIRGNRVLIGFSLP-GKTIGMQSRA
MAV_4549|M.avium_104 TDAGGINVGDKVQIAGVNVGLVSSLVIRGDRVLVGFSMP-GKTIGAQSRA
MMAR_0414|M.marinum_M TDSGGINNGDKVRIAGLDVGKVEGLRIDGDHIVMKFSIG-TNTIGTDSRL
MUL_1064|M.ulcerans_Agy99 TDSGGINNGDKVRIAGLDVGKVEGLRIDGDHIVMKFSIG-TNTIGTDSRL
MLBr_02591|M.leprae_Br4923 TDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TNRIGTASRL
Mflv_0709|M.gilvum_PYR-GCK SDTGGLNSGDNVRIAGVDVGTVRSLEIDGDRVRIGYSLG-GTEIGTDSLA
Mvan_0136|M.vanbaalenii_PYR-1 SDTGGINSGDKVRIAGVDVGTVRSMEIDGDRVLIGYGLG-GTEIGTESRV
MSMEG_0136|M.smegmatis_MC2_155 ADTGGLNIGDKVRIAGMDVGNVKSMEIDGDKVVIGYTLG-GRTIGTESRA
TH_3066|M.thermoresistible__bu YDTGGIKAGDKVRIAGVDVGLVRSATINGDKVRIGFTLG-GVQIGTDSRA
MAB_4151c|M.abscessus_ATCC_199 ADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSLA
* **:: *.:* ::*:.** * : *::: : : : :* *
Rv0591|M.tuberculosis_H37Rv AIRTDTILGRKNLEIEPRGSEPLKPNGFLPLAQTTTPYQIYDAFVDVTKA
Mb0606|M.bovis_AF2122/97 AIRTDTILGRKNLEIEPRGSEPLKPNGFLPLAQTTTPYQIYDAFVDVTKA
MAV_4549|M.avium_104 AIRTDTFLGRKNMAIQPRGADPLPPNGIIPSGQTTTPYQIYDAFVDVTKA
MMAR_0414|M.marinum_M SIRTDTILGKKVVEIEARGNQPLRPGGTLPLGQSTTPYQIYDAFFDVTRA
MUL_1064|M.ulcerans_Agy99 SIRTDTILGKKVVEIEARGNQPLRPGGTLPLGQSTTPYQIYDAFFDVTRA
MLBr_02591|M.leprae_Br4923 GIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATKV
Mflv_0709|M.gilvum_PYR-GCK AIRTDTILGRRNMEIEPRGSDPLQANGVLPLGQTTTPYQIYDAFFDVSKN
Mvan_0136|M.vanbaalenii_PYR-1 AIRTDTILGRRNLEIDPRGSEPLRANGVLPLGQTTTPYQIYDAFFDVSNN
MSMEG_0136|M.smegmatis_MC2_155 AIRTDTILGRKNIEIEPRGSETLKPRGVLPVGQTSAPYQIYDAFLDVTRN
TH_3066|M.thermoresistible__bu SIRTDTILGRKNMEIEPRGTEPLRTNGVLPIGQTTTPYQIYDAFFDVTKA
MAB_4151c|M.abscessus_ATCC_199 AIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGAS
.*** *.**.: : : . * : :* .::::** .*: *
Rv0591|M.tuberculosis_H37Rv ATGWDIDAVKRSLNVLSETFDQTAPHLSAALEGVKAFSDTVGRRGEQIEQ
Mb0606|M.bovis_AF2122/97 ATGWDIDAVKRSLNVLSETFDQTAPHLSAALEGVKAFSDTVGRRGEQIEQ
MAV_4549|M.avium_104 ATDWNIDVVKRSLNVLSETFDQTAPHLKAALDGVARFSGTIGNRDEQIKQ
MMAR_0414|M.marinum_M ATGWDIDTVKKSLHVLSETIDQTYPHLSSALDGVAKFSDTLGKRDDELKH
MUL_1064|M.ulcerans_Agy99 ATGWDIDTVKKSLHVLSETIDQTYPHLSSALDGVAKFSDTLGKRDDELKH
MLBr_02591|M.leprae_Br4923 ASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIKH
Mflv_0709|M.gilvum_PYR-GCK TAGWDTQTVKESLNVLSETIDQTYPHLSAALDGVARFSDTIGKRDDQIKQ
Mvan_0136|M.vanbaalenii_PYR-1 TAGWDTKTVRDSLNVLSETIDQTSPHLSAALDGVARFSDTIGKRDEQIKQ
MSMEG_0136|M.smegmatis_MC2_155 AAGWDTQAVRQSLNVLSETVDQTSPHLSAALDGVARFSETIGKRDEDVKK
TH_3066|M.thermoresistible__bu ATEWDTRTVRESLNVLSETIDQTYPHLSAALDGVARFSDTIGKRDEQITQ
MAB_4151c|M.abscessus_ATCC_199 AGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALEQ
: : : **:*::*:. :: *:* .**:** :* *:. *. : :
Rv0591|M.tuberculosis_H37Rv LLANANRIARVLGDRSEQVNGLLVNAKTLLAAFKQRSQALRILLTNVSEA
Mb0606|M.bovis_AF2122/97 LLANANRIARVLGDRSEQVNGLLVNAKTLLAAFKQRSQALRILLTNVSEA
MAV_4549|M.avium_104 LLTNADKITRVLGDRSGQVDALLVNANTLLAAFRQRSQALSALLSNVSAV
MMAR_0414|M.marinum_M LLAQANQVASVLGDRSAQVDRLLVNAKTLLVAFNERGRAIDALLGNIASF
MUL_1064|M.ulcerans_Agy99 LLAQANQVASALGDRSAQVDRLLVNAKTLLVAFNERGRAIDALLGNIASF
MLBr_02591|M.leprae_Br4923 LIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAAF
Mflv_0709|M.gilvum_PYR-GCK LLANANKVAGVLGNRSEQINQLFVNAQTLLAAVNERNYAVSQLLERVDTF
Mvan_0136|M.vanbaalenii_PYR-1 LLANANKVAGVLGNRSEQINQLFVNAQSLLAAINERNYAVSQLLERVDTF
MSMEG_0136|M.smegmatis_MC2_155 LLASANKVATVLGDRSTQVNQLLVNAQTLLAAVNERGRSVSLLLERVSSV
TH_3066|M.thermoresistible__bu LLANANKIAEVLGDRGGQINALLVNAQTLLGAINERTQAVDLLLQRISQV
MAB_4151c|M.abscessus_ATCC_199 LLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQGL
*:: *. :: *.:*. *:: *..: : *: *. :* :: *: .:
Rv0591|M.tuberculosis_H37Rv SAQVSGLITDN-PNLNHVLAQLRTVSEELVKRKNELADVAVLLGRYTAAL
Mb0606|M.bovis_AF2122/97 SAQVSGLITDN-PNLNHVLAQLRTVSEELVKRKNELADVAVLLGRYTAAL
MAV_4549|M.avium_104 STQVSGFIKEN-PDAHQVLRQLGTVSDELVKRKKELSDVLVLVSRYTASL
MMAR_0414|M.marinum_M SAQVQGLINDN-PNLNHVLEQLRTVSDVLIERKEDLAKGLEMVGAFLPSL
MUL_1064|M.ulcerans_Agy99 SAQVQGLINDN-PNLNHVLEQLRTVSDVLIERKEDLAKGLEMVGAFLPSL
MLBr_02591|M.leprae_Br4923 AAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPSL
Mflv_0709|M.gilvum_PYR-GCK STQVRGFIDDN-PNLNNVLEQLRVITDVLAARKLDITDTLSSLSKFMVSL
Mvan_0136|M.vanbaalenii_PYR-1 STQVRGFIDDN-PNLNHVLEQLRVISDVLAERKLDLADTLSSLSKFMVSL
MSMEG_0136|M.smegmatis_MC2_155 SRQVEGFVDEN-PNLNHVLEQLRTVSDVLNERKQDLADILTVAGKFITSL
TH_3066|M.thermoresistible__bu STQVRGFIDDN-PNLNTVLEQLRQVSDILVERRYDLVDVLSSLSKFTASL
MAB_4151c|M.abscessus_ATCC_199 SQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTAL
: *: :: :* : . .: :* : * :: .: . : :*
Rv0591|M.tuberculosis_H37Rv TEAVGSGPFFKAMVVNLLPYQILQPWVDAAFKKRGIDPENFWRSAGLPEF
Mb0606|M.bovis_AF2122/97 TEAVGSGPFFKAMVVNLLPYQILQPWVDAAFKKRGIDPENFWRSAGLPEF
MAV_4549|M.avium_104 TEAVASGPFFKAIVANLLPYQVLQPWVDAAFKKRGIDPENFWRSAGLPAF
MMAR_0414|M.marinum_M NESIASGPFFKVVIHNLVPGQILQPFIDAAFKKRGLSPEDFWRSAGLPEY
MUL_1064|M.ulcerans_Agy99 NESIASGPFFKVVIHNLVPGQILQPFIDAAFKKRGLSPEDFWRSAGLPEY
MLBr_02591|M.leprae_Br4923 NEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPEF
Mflv_0709|M.gilvum_PYR-GCK GEALASGPYFKVMLANLAPYWILQPFVDAAFKKRGINPEEFWRNAGLPAF
Mvan_0136|M.vanbaalenii_PYR-1 GEALASGPYFKVMLANLAPYWILQPFVDAAFKKRGINPEEFWRNAGLPAF
MSMEG_0136|M.smegmatis_MC2_155 AEALASGPYFKVMLVNLIPPTILQPFVDAAFKKRGIDPEEFWRNAGLPAF
TH_3066|M.thermoresistible__bu AEGLASGPYFKVMLVNLVPYQILQPFVDAAFKERGIDPENFWRGAGLPEF
MAB_4151c|M.abscessus_ATCC_199 GEVVSSGPGFHVNVYGFPPATLTAVAFDTYFQP-----------------
* :.*** *:. : .: * : .*: *:
Rv0591|M.tuberculosis_H37Rv RWPDPNGTRFPNGAPPAAPPVREGTPKHPGPAVPPGTPCSYTPAAG----
Mb0606|M.bovis_AF2122/97 RWPDPNGTRFPNGAPPAAPPVREGTPKHPGPAVPPGTPCSYTPAAG----
MAV_4549|M.avium_104 RWPDPNGTRLPNGAPPPAPPVAEGTPAHPGPAVPPGSPCSYTPAAD----
MMAR_0414|M.marinum_M RFPDPNGTRFPNGAPPPGPRVLEGTPDHPLPAVPPGSPCSYTPAAD----
MUL_1064|M.ulcerans_Agy99 RFPDPKGTRFPNGAPPPGPRVLEGTPDHPLPAVPPGSPCSYTPAAD----
MLBr_02591|M.leprae_Br4923 RFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGNN
Mflv_0709|M.gilvum_PYR-GCK RFPDPNGVGFENGAPPPAPTPIEGTPENPGPAVPPGSPCSYTPPGN----
Mvan_0136|M.vanbaalenii_PYR-1 RFPDPNGVGFENGAPPPAPTPIEGTPENPGPAVPPGSPCSYTPPAD----
MSMEG_0136|M.smegmatis_MC2_155 RFPDPNGERHENGAPPAAPTPLEGTPEHPGPAVPPGSPCSYTPPAD----
TH_3066|M.thermoresistible__bu QWPDPNAERHANGAPPAAPRPIEGTPEHPGPAVPPGHPCSYTPAAN----
MAB_4151c|M.abscessus_ATCC_199 ------------GKLPASLSDYLNGLIGERQIMRPKSP------------
* *.. . : * *
Rv0591|M.tuberculosis_H37Rv ------ALPRPDTPLPCAGATVGPFG-GPD-FPAPLD-VQPSPPNPDGPP
Mb0606|M.bovis_AF2122/97 ------ALPRPDNPLPCAGATVGPFG-GPD-FPAPLD-VQPSPPNPDGPP
MAV_4549|M.avium_104 ------SPPRPGNPLPCALSGQGPFGPVPDGFPAPLD-VETSPPAPDGPP
MMAR_0414|M.marinum_M ------ALPRPDNPLPCAGVLEGPFG-GFG-FPAPLDGVESSPPNPNGLP
MUL_1064|M.ulcerans_Agy99 ------ALPRPDNPLPCAGVLEGPFG-GFG-FPAPLDGVESSPPNPNGLP
MLBr_02591|M.leprae_Br4923 TIGDEMGLPRPWNPLPCAGATAGPYG-GPA-FPAPID-VQTSPPNPDGLP
Mflv_0709|M.gilvum_PYR-GCK ------GLPSPGNPLPCASLTQGPYGPVPGG--YPPPNVVTSEPNVHGPQ
Mvan_0136|M.vanbaalenii_PYR-1 ------GLPRPGNPLPCAGLTQGPYGPVPGG--FPPPNVATSAPNAHGPQ
MSMEG_0136|M.smegmatis_MC2_155 ------GIPSPGNPLPCAHLSQGPYGPVPGG--YPPPNVATSAPNPDGIA
TH_3066|M.thermoresistible__bu ------AAPRPGDPLPCADAGVGPFGDNPYGPNYAPPNVVG-EPHNPDAQ
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Rv0591|M.tuberculosis_H37Rv PTPGILSAGRPGEPAPAVPGIPMPLPPNAPPGARTQPLE-----------
Mb0606|M.bovis_AF2122/97 PTPGILSAGRPGEPAPAVPGIPMPLPPNAPPGARTQPLE-----------
MAV_4549|M.avium_104 PSPGVPSAGRPGEAPPDVPGTPVPLPAHAPPGARTE--------------
MMAR_0414|M.marinum_M PTPGIPIAGRPGEPAPDAPGTPVPLPPDAPPGARTEPVGPAGPTPPPSTF
MUL_1064|M.ulcerans_Agy99 PTPGIPIPGRPGEPAPDAPGTPVPLPPDAPPGARTEPVGPAGPTPPPSTF
MLBr_02591|M.leprae_Br4923 LLPGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPAQDSS--
Mflv_0709|M.gilvum_PYR-GCK PSPGVPAAAIPGQLSPEVPGAR-PPLPPAPPGARTVPLAPQPAPADFT--
Mvan_0136|M.vanbaalenii_PYR-1 PSPGVPAAAIPGQLSPAVPGAR-PPLPPAPPGARTVPLEPQPSPPDFT--
MSMEG_0136|M.smegmatis_MC2_155 HSPGVPSAAIPGQMPPEQPGAP-VEIAPGPPGARTVPVSPIPGAPDFT--
TH_3066|M.thermoresistible__bu PSPGLPAAAVPGQVSPNVPGAPGPGVAPGPPGX-----------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Rv0591|M.tuberculosis_H37Rv ----------------------PFPDGTGGSNQ-----------------
Mb0606|M.bovis_AF2122/97 ----------------------PFPDGTGGSNQ-----------------
MAV_4549|M.avium_104 ----------------------NPPDATGGSTR-----------------
MMAR_0414|M.marinum_M APGLPPGPPAPPGPGPQLPDPYITPGGTGGSGATGGSQN-----------
MUL_1064|M.ulcerans_Agy99 APGLPPGPPAPPGPGPQLPDPYITPGGTGGSGATGGSQN-----------
MLBr_02591|M.leprae_Br4923 ---------APHEPREQLSAPLINPGGTGGSGGAGGSRN-----------
Mflv_0709|M.gilvum_PYR-GCK ---------PGIAPLPPALTGPPPPPGPGPSPGPAGQPLLPGNPPFLPPG
Mvan_0136|M.vanbaalenii_PYR-1 ---------PGIAPLPPALTGPPPPAGPGPAPAPAGQPLLPGNPPFLPPG
MSMEG_0136|M.smegmatis_MC2_155 ---------PGIAPPPPAITGPPPPPGPGPQLAPVGEAPLPGNPPFLPPG
TH_3066|M.thermoresistible__bu -----------------XXARRPARSSPGRSPAP----------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Rv0591|M.tuberculosis_H37Rv ----
Mb0606|M.bovis_AF2122/97 ----
MAV_4549|M.avium_104 ----
MMAR_0414|M.marinum_M ----
MUL_1064|M.ulcerans_Agy99 ----
MLBr_02591|M.leprae_Br4923 ----
Mflv_0709|M.gilvum_PYR-GCK SQG-
Mvan_0136|M.vanbaalenii_PYR-1 SQG-
MSMEG_0136|M.smegmatis_MC2_155 SQSR
TH_3066|M.thermoresistible__bu ----
MAB_4151c|M.abscessus_ATCC_199 ----