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GSKNGTVPRWMSGSDPTASLWRAAQVFRLASFGYALLASQLASYTNYERQGLSWALYAVMAMWTGFAAVA LSRNWFRRWQLVLCDQAIVIALMLAGRLVVDVQWYSGHQTLPTTLWVANAVVSMGLLRGQLAGVISGFVL AAVSIAARGLPVSALWLDATMPALVVVGLAIGAASTTAKRTFHELRRAERAAAAAIERERLSRQVHDGVL QVLSYVKRRGTEIGGPTAELAAIAGEQEIALRELISGATQTTLADDELVDLRPLLRTQASTTVSVSAPGA PVLIGQHMASELAAVVRSALSNVALHAGPQAHAYVLIEDLVDSVVVTVRDDGSGIADGRLDQAEREGRMG VSRSILGRVADLGGAVLLETGPGAGTEWEITVPKSQEVGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4520c | - | - | 100% (391) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_3715c | - | 2e-12 | 29.28% (263) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_4499 | - | 6e-08 | 26.96% (230) | putative two-component system sensor kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0868 | - | 1e-10 | 25.50% (400) | two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_3580 | - | 3e-89 | 49.86% (365) | putative signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0845 | - | 3e-10 | 25.87% (402) | two component sensor kinase |
| M. leprae Br4923 | MLBr_00803 | - | 4e-07 | 25.83% (240) | putative two-component system sensor kinase |
| M. marinum M | MMAR_3958 | - | 2e-95 | 50.53% (374) | two-component sensor kinase |
| M. avium 104 | MAV_4112 | - | 2e-90 | 47.33% (374) | hypothetical protein MAV_4112 |
| M. smegmatis MC2 155 | MSMEG_3239 | - | 1e-89 | 48.53% (373) | two-component system sensor kinase |
| M. thermoresistible (build 8) | TH_1288 | - | 2e-90 | 48.65% (370) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_2542 | - | 2e-08 | 27.62% (239) | sensor kinase from two component regulatory system |
| M. vanbaalenii PYR-1 | Mvan_2835 | - | 5e-90 | 49.73% (370) | putative signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0868|M.bovis_AF2122/97 ----------------------------------MPSYGNLGRLGGRHEY
Rv0845|M.tuberculosis_H37Rv ----------------------------------MPSYGNLGRLGGRHEY
Mflv_3580|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2835|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3239|M.smegmatis_MC2_155 --------------------------------------------------
TH_1288|M.thermoresistible__bu --------------------------------------------------
MMAR_3958|M.marinum_M --------------------------------------------------
MAV_4112|M.avium_104 --------------------------------------------------
MAB_4520c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00803|M.leprae_Br4923 MSTLGDLLAEHTVLPGNAVGHLHAVVGEWQLLADLSFADYLMWVSRDDGV
MUL_2542|M.ulcerans_Agy99 MSTLGNLLAENTMLPGNAVDHLHAVVGEWQLLADLSFADYLMWVARDDGA
Mb0868|M.bovis_AF2122/97 GVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSR--
Rv0845|M.tuberculosis_H37Rv GVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSR--
Mflv_3580|M.gilvum_PYR-GCK ----------------------MWRAAQVFRLLSCVYAFG-FQLAVN---
Mvan_2835|M.vanbaalenii_PYR-1 --------------MTPDPATPLWRAAQVFRLLSCIYAFG-FQLAVN---
MSMEG_3239|M.smegmatis_MC2_155 ------------MQREPDPVTPLWRAAQGFRLLSCLYALG-FHIAIT---
TH_1288|M.thermoresistible__bu -----------MAAERVDPATPLWRAAQVFRLLSCLYAVG-FQIAVN---
MMAR_3958|M.marinum_M -----------MATRGPDPTAPLWRAAQLFRLLSCGYALG-FHIAIN---
MAV_4112|M.avium_104 -------MLTTMANHGPDPTTPLWRAAQVFRLLSCLYATG-FQIAIN---
MAB_4520c|M.abscessus_ATCC_199 --MGSKNGTVPRWMSGSDPTASLWRAAQVFRLASFGYALLASQLASY---
MLBr_00803|M.leprae_Br4923 LVCVAQCRPHTAPTVLQTDAVGSVASADMLPLVTEMFTSGAVQHEDAAGQ
MUL_2542|M.ulcerans_Agy99 LVCVAQCRPNTAPTVLQTDAVGSVVEADRLPLVAETFASGSARRDSDADQ
*. : :
Mb0868|M.bovis_AF2122/97 --------SEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGR
Rv0845|M.tuberculosis_H37Rv --------SEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGR
Mflv_3580|M.gilvum_PYR-GCK --------ADLESPVAGWVLFGALLAWSLACAVAYLQGFGRRLSWVLAEV
Mvan_2835|M.vanbaalenii_PYR-1 --------PDLEHPVGGWVLFAVLIGWSAACATAYLQGFGRRPAWVLAEI
MSMEG_3239|M.smegmatis_MC2_155 --------DDLRRPVLGWVLFAGLIVWSAACATVYLTGSRRRGTWVIAEL
TH_1288|M.thermoresistible__bu --------GDLRHPAAGWLMLAVLLAWSAACAVGYLNGFARRPGWVIAEI
MMAR_3958|M.marinum_M --------ANLQRPLLGWALFAVLIGWSAACAVAYLRGFGRRPAWVITEI
MAV_4112|M.avium_104 --------PDLLRPVLGWVLFAGLIGWSAACALAYLRGFGRKPAWVLAEL
MAB_4520c|M.abscessus_ATCC_199 --------TNYERQGLSWALYAVMAMWTGFAAVALSRNWFRRWQLVLCDQ
MLBr_00803|M.leprae_Br4923 QYSWLPFGRNVAASPVRYGDQVVAVLTQHQVELAARRRPGNLEIAYLACA
MUL_2542|M.ulcerans_Agy99 QHLGQLPGPSIEASPVRYGDQVVAVLTQHQTAVAAERASGHLESAYRDCA
.
Mb0868|M.bovis_AF2122/97 LEPFAFTAVDVLILTGFQLLSTDGIYP-----------LLIMILLPVLVG
Rv0845|M.tuberculosis_H37Rv LEPFAFTAVDVLILTGFQLLSTDGIYP-----------LLIMILLPVLVG
Mflv_3580|M.gilvum_PYR-GCK AVVIALVLSTEFLAS-DQWALDNQSWP-----------TTLWATNATISA
Mvan_2835|M.vanbaalenii_PYR-1 VVVVALMLSTEFVAS-DQWALDNQSWP-----------TTLWATNATISA
MSMEG_3239|M.smegmatis_MC2_155 VVVVALMLSTELVAS-EQWIADNQSWP-----------TTLWATNATISV
TH_1288|M.thermoresistible__bu VVVIALMLATGLIAD-AAWVADNQSLP-----------TTLWATNATISA
MMAR_3958|M.marinum_M AVVVVLMLSTKMVAS-AQWALDNQTWP-----------TTLWASNATISA
MAV_4112|M.avium_104 VVVVLLMWSNHLVAS-PHWAADNQTWP-----------TTLWASNPTISA
MAB_4520c|M.abscessus_ATCC_199 AIVIALMLAGRLVVD-VQWYSGHQTLP-----------TTLWVANAVVSM
MLBr_00803|M.leprae_Br4923 TDLLHMLAEGTFPDVGDVAVSHSTPRAGDGFIRLDRNGVVAFASPNALSA
MUL_2542|M.ulcerans_Agy99 TDLLQMLAEGTFPDVGDVAMSRSTPRAGDGFIRLDVDGVAIYASPNALSA
. : : . .:
Mb0868|M.bovis_AF2122/97 LDVSTRRAAVVLA-----------------CTLVGFAVAVLGDPVMLRAI
Rv0845|M.tuberculosis_H37Rv LDVSTRRAAVVLA-----------------CTLVGFAVAVLGDPVMLRAI
Mflv_3580|M.gilvum_PYR-GCK AILSGPVAGMLAG-----------------LAVVAAGAALKG--YVSIDL
Mvan_2835|M.vanbaalenii_PYR-1 AILSGPVSGMLAG-----------------LVVVAASAALKG--YVSIDL
MSMEG_3239|M.smegmatis_MC2_155 ALHFGPIGGMSAG-----------------LAVMATVALLKG--HVSVNL
TH_1288|M.thermoresistible__bu AIQFGPVRGMLTG-----------------VAVMLAAAALKG--HISINL
MMAR_3958|M.marinum_M ALQFGPAGGMLTG-----------------IAVTAANEAVKG--YVNVNL
MAV_4112|M.avium_104 AIQFGPVGGMLTG-----------------LAVMTANFAVKN--YFALNL
MAB_4520c|M.abscessus_ATCC_199 GLLRGQLAGVISG-----------------FVLAAVSIAARG--LPVSAL
MLBr_00803|M.leprae_Br4923 FHRMGLTAELQGRNLVKVTRPLLSDPFEAQEVAKHVQDLLDGGPSMRVEV
MUL_2542|M.ulcerans_Agy99 YHRMGLTTELEGHELIEVTRPLISDPFEAEEVAEHVRDLLVGGRSMRMEV
: . . :
Mb0868|M.bovis_AF2122/97 GWPETIFRFALYAFLCATALMVVRIEERHTRSVAGLSALREELLAQTMTA
Rv0845|M.tuberculosis_H37Rv GWPETIFRFALYAFLCATALMVVRIEERHTRSVAGLSALRAELLAQTMTA
Mflv_3580|M.gilvum_PYR-GCK GRNATIVIELAVGLAVGMAAQTARRAHAELERATRLAASLEE--------
Mvan_2835|M.vanbaalenii_PYR-1 GRNATVVIELAVGLAVGMAAQTARRAHAELERAARLSASLEE--------
MSMEG_3239|M.smegmatis_MC2_155 GRNATIVIELAVGLAVGMAAQTARRAHAELERAVRLSAALEE--------
TH_1288|M.thermoresistible__bu GRNATIVIELAVGLAVGMAAQTARRAHAELRRAARLAAVTEE--------
MMAR_3958|M.marinum_M GRSATIVIELAVGLAVGMAARTARRAHADLQRAAQLSAALQE--------
MAV_4112|M.avium_104 GHNATVIIELAIGMAIGMAAQTARRAHDELQRAARLTAAAQE--------
MAB_4520c|M.abscessus_ATCC_199 WLDATMPALVVVGLAIGAASTTAKRTFHELRRAERAAAAAIE--------
MLBr_00803|M.leprae_Br4923 NAGGATVLLRTLPLVVHGSSVGAAVLVRDVTEVKRRDRALIS--------
MUL_2542|M.ulcerans_Agy99 DAGGATVLLRTLPLVVGGVSAGAAILIRDVTEVKRRDRALIS--------
: : . . . .
Mb0868|M.bovis_AF2122/97 SEVLQRRIAEAIHDGPLQDVLAARQELIELDAVTPGDERVGRALAGLQSA
Rv0845|M.tuberculosis_H37Rv SEVLQRRIAEAIHDGPLQDVLAARQELIELDAVTPGDERVGRALAGLQSA
Mflv_3580|M.gilvum_PYR-GCK ----RERLSRQVHDGAIQVLALVARRGREIGGDT---AQLAELAGEQERA
Mvan_2835|M.vanbaalenii_PYR-1 ----RERLSRQVHDGAIQVLALVARRGREIGGDT---AQLAELAGEQERA
MSMEG_3239|M.smegmatis_MC2_155 ----RERLSRRVHDGAIQVLALVARRGREIGGET---AKLAELAGEQERA
TH_1288|M.thermoresistible__bu ----RERLSRQVHDGAIQVLALVARRGREIGGEV---TELAELAGEQERA
MMAR_3958|M.marinum_M ----RERLSRQVHDGVIQVLALVSRRGHEIGGPT---SELAELASEQERA
MAV_4112|M.avium_104 ----RDRLARQVHDGAIQVLALVAKKGHEIGGAT---TELADLASEQERA
MAB_4520c|M.abscessus_ATCC_199 ----RERLSRQVHDGVLQVLSYVKRRGTEIGGPT---AELAAIAGEQEIA
MLBr_00803|M.leprae_Br4923 ----KDATIREIHHRVKNNLQTVAALLRLQARRMAN-AEGREALIESVRR
MUL_2542|M.ulcerans_Agy99 ----KDATIREIHHRVKNNLQTVAALLRLQARRTTN-AEGREALTESVRR
: . :*. : : . .
Mb0868|M.bovis_AF2122/97 SERLRQATFELHPAVLEQVGLGPAVKQLA-----ASTAQRSGIKISTDID
Rv0845|M.tuberculosis_H37Rv SERLRQATFELHPAVLEQVGLGPAVKQLA-----ASTAQRSGIKISTDID
Mflv_3580|M.gilvum_PYR-GCK LRRLVSAADTPHR-AGATADLGAMLRSRA-----SDRVSVS----VPAEP
Mvan_2835|M.vanbaalenii_PYR-1 LRRLVSANDAEPR-KGAMSDIGAMLRRRA-----TDRVSIS----VPADP
MSMEG_3239|M.smegmatis_MC2_155 LRRLVSAADTDTM-AGPLTDVGALLRTRA-----SDRVSVS----VPAEP
TH_1288|M.thermoresistible__bu LRRLVSATESAPGGADHTVDVATLLRRRA-----CDRVTMS----LPGTP
MMAR_3958|M.marinum_M LRRWIISTDTDRDGNTRSVDLCALLRRRA-----SDRVSMS----LPGTP
MAV_4112|M.avium_104 LRRWLACTDIDRDADGDTVDLRTLLRRRE-----SDRVSIS----LPGTP
MAB_4520c|M.abscessus_ATCC_199 LRELISGATQTTLADDELVDLRPLLRTQA-----STTVSVS----APGAP
MLBr_00803|M.leprae_Br4923 VSSIALVHDALSMSVDEQVNLDEVIDRILPIMNDVASVDRPIRINRVGNL
MUL_2542|M.ulcerans_Agy99 VSSIALVHDALSMSVDEQVNLDEVIDRILPIMNDVASVDRPIRINRVGDL
.: : . .
Mb0868|M.bovis_AF2122/97 YPIRSGIDPIVFGVVRELLSNVVRHSG-ATTASVRLGITDEK----CVLD
Rv0845|M.tuberculosis_H37Rv YPIRSGIDPIVFGVVRELLSNVVRHSG-ATTASVRLGITDEK----CVLD
Mflv_3580|M.gilvum_PYR-GCK VLLDSAVATEFFAAVTNALDNAEAHAGPHARVYVLLEDLGDS----VTVS
Mvan_2835|M.vanbaalenii_PYR-1 VLLDATVADELLAAVTNALDNVEAHAGPVARAYVLLEDLGAT----VTVT
MSMEG_3239|M.smegmatis_MC2_155 VLLDHPVARELFAAAENALDNVAAHAGADARAFVLLEDLGEE----VTVS
TH_1288|M.thermoresistible__bu VPMDADVAAELDAAVGNALDNVALHAGPDARAFVLVEDLGDT----VTVS
MMAR_3958|M.marinum_M VTLTREVATELDAAVGNALDNVRLHAGPSARAFVLLEDLGDS----VTVS
MAV_4112|M.avium_104 VRLGRWAATELDAAVGNALDNVVAHAGPGAHAFVLVEDLGDS----VLVS
MAB_4520c|M.abscessus_ATCC_199 VLIGQHMASELAAVVRSALSNVALHAGPQAHAYVLIEDLVDS----VVVT
MLBr_00803|M.leprae_Br4923 GMLDSDRATALIMVITELVQNAIEHAFDPASQEGFVAISAERSARWLDVV
MUL_2542|M.ulcerans_Agy99 GVLDSDRATALIMVITELVQNAIEHAFDPAAQ-GAVTIRAERSARWLDVV
: . . . :.*. *: : : :
Mb0868|M.bovis_AF2122/97 VADDGVGVTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATPRGTHVC
Rv0845|M.tuberculosis_H37Rv VADDGVGVTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATPRGTHVC
Mflv_3580|M.gilvum_PYR-GCK VRDDGVGIPEGRLEAAVGEGRVGVAKSIVGRMNWLGGRAELATGPGVGTE
Mvan_2835|M.vanbaalenii_PYR-1 VRDDGVGIPEGRLDEAVTEGRVGVSKSIVGRMDWLGGRAELSTGPGMGTE
MSMEG_3239|M.smegmatis_MC2_155 IRDDGVGIPEGRLAEAERQGRMGVAKSIVGRMDWLGGTAVLTTGPDSGTE
TH_1288|M.thermoresistible__bu IRDDGAGIAPGRLDEAVREGRMGIAKSIVGRMESLGGEAVLTTS-ERGTE
MMAR_3958|M.marinum_M VRDDGVGIAPGRLDEAAGQGHLGISKSIVGRLAALGGTAELSTDQGEGTE
MAV_4112|M.avium_104 VRDDGVGIAAGRVEEAARQGRLGISQSIVGRLASLGGTAELHSEPGAGTE
MAB_4520c|M.abscessus_ATCC_199 VRDDGSGIADGRLDQAEREGRMGVSRSILGRVADLGGAVLLETGPGAGTE
MLBr_00803|M.leprae_Br4923 VHDDGRGLPQGFNLERSDSLGLQIVRTLVSSELDGSLGMRKAPNRGTDVV
MUL_2542|M.ulcerans_Agy99 VHDDGRGLPSGFSLEKSDSLGLQIVRTLVSAELDGSLGMREAPGRGTDVV
: *** *:. . . : : . . .
Mb0868|M.bovis_AF2122/97 VELPLKR-------
Rv0845|M.tuberculosis_H37Rv VELPLKR-------
Mflv_3580|M.gilvum_PYR-GCK WELTVPR-------
Mvan_2835|M.vanbaalenii_PYR-1 WELTVSR-------
MSMEG_3239|M.smegmatis_MC2_155 WELTVPRTRKGQ--
TH_1288|M.thermoresistible__bu WELTVPRKDGRHG-
MMAR_3958|M.marinum_M WELRVPRREGSS--
MAV_4112|M.avium_104 WELCVPRREGRDDG
MAB_4520c|M.abscessus_ATCC_199 WEITVPKSQEVGA-
MLBr_00803|M.leprae_Br4923 LRVPIGRRARLLL-
MUL_2542|M.ulcerans_Agy99 LRVPIGRRGRLLA-
.: : :