For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MATRGPDPTAPLWRAAQLFRLLSCGYALGFHIAINANLQRPLLGWALFAVLIGWSAACAVAYLRGFGRRP AWVITEIAVVVVLMLSTKMVASAQWALDNQTWPTTLWASNATISAALQFGPAGGMLTGIAVTAANEAVKG YVNVNLGRSATIVIELAVGLAVGMAARTARRAHADLQRAAQLSAALQERERLSRQVHDGVIQVLALVSRR GHEIGGPTSELAELASEQERALRRWIISTDTDRDGNTRSVDLCALLRRRASDRVSMSLPGTPVTLTREVA TELDAAVGNALDNVRLHAGPSARAFVLLEDLGDSVTVSVRDDGVGIAPGRLDEAAGQGHLGISKSIVGRL AALGGTAELSTDQGEGTEWELRVPRREGSS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3958 | - | - | 100% (380) | two-component sensor kinase |
| M. marinum M | MMAR_3479 | - | 3e-07 | 25.48% (263) | two-component sensor histidine kinase |
| M. marinum M | MMAR_5316 | tcrY | 1e-06 | 26.03% (242) | two-component sensor kinase TcrY |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | 8e-06 | 22.19% (356) | two component system response sensor kinase membrane |
| M. gilvum PYR-GCK | Mflv_3580 | - | 1e-140 | 68.41% (364) | putative signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0758 | phoR | 1e-05 | 21.91% (356) | two component system response sensor kinase membrane |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4520c | - | 2e-95 | 50.53% (374) | putative two-component system sensor kinase |
| M. avium 104 | MAV_4112 | - | 1e-161 | 74.60% (378) | hypothetical protein MAV_4112 |
| M. smegmatis MC2 155 | MSMEG_3239 | - | 1e-139 | 69.35% (372) | two-component system sensor kinase |
| M. thermoresistible (build 8) | TH_1288 | - | 1e-148 | 68.52% (378) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_0464 | phoR | 5e-05 | 27.18% (195) | two component system response phosphate sensor kinase, PhoR |
| M. vanbaalenii PYR-1 | Mvan_2835 | - | 1e-145 | 70.54% (370) | putative signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3958|M.marinum_M ---------MATRGPDPTAPLWRAAQLFRLLSCGYALG-FHIAINANLQR
MAV_4112|M.avium_104 -----MLTTMANHGPDPTTPLWRAAQVFRLLSCLYATG-FQIAINPDLLR
Mflv_3580|M.gilvum_PYR-GCK --------------------MWRAAQVFRLLSCVYAFG-FQLAVNADLES
Mvan_2835|M.vanbaalenii_PYR-1 ------------MTPDPATPLWRAAQVFRLLSCIYAFG-FQLAVNPDLEH
MSMEG_3239|M.smegmatis_MC2_155 ----------MQREPDPVTPLWRAAQGFRLLSCLYALG-FHIAITDDLRR
TH_1288|M.thermoresistible__bu ---------MAAERVDPATPLWRAAQVFRLLSCLYAVG-FQIAVNGDLRH
MAB_4520c|M.abscessus_ATCC_199 MGSKNGTVPRWMSGSDPTASLWRAAQVFRLASFGYALLASQLASYTNYER
Mb0781|M.bovis_AF2122/97 -------MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLT
Rv0758|M.tuberculosis_H37Rv -------MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLT
MUL_0464|M.ulcerans_Agy99 -------MAERLPRAVQLRVGLVAATLALVLCGLLASGVAVTSILRHSLV
** : * : .
MMAR_3958|M.marinum_M PLLGWALFAVLIGWSAACAVAYLRGF---------GRRPAWVITEIAVVV
MAV_4112|M.avium_104 PVLGWVLFAGLIGWSAACALAYLRGF---------GRKPAWVLAELVVVV
Mflv_3580|M.gilvum_PYR-GCK PVAGWVLFGALLAWSLACAVAYLQGF---------GRRLSWVLAEVAVVI
Mvan_2835|M.vanbaalenii_PYR-1 PVGGWVLFAVLIGWSAACATAYLQGF---------GRRPAWVLAEIVVVV
MSMEG_3239|M.smegmatis_MC2_155 PVLGWVLFAGLIVWSAACATVYLTGS---------RRRGTWVIAELVVVV
TH_1288|M.thermoresistible__bu PAAGWLMLAVLLAWSAACAVGYLNGF---------ARRPGWVIAEIVVVI
MAB_4520c|M.abscessus_ATCC_199 QGLSWALYAVMAMWTGFAAVALSRNW---------FRRWQLVLCDQAIVI
Mb0781|M.bovis_AF2122/97 SRIDRVLLEEAQIWAQITLPLAPDPYPIHNPDRPPSRFYVRVISPDGQSY
Rv0758|M.tuberculosis_H37Rv SRIDRVLLEEAQIWAQITLPLAPDPYPGHNPDRPPSRFYVRVISPDGQSY
MUL_0464|M.ulcerans_Agy99 SRIDSTLLEASRTWAQASWRHSMPSVEGPDPARPPSKFYVRSISPDGRAM
. : *: : :
MMAR_3958|M.marinum_M VLMLSTKMVASAQWALDNQTWPTTLWASN--ATISAALQFGPAGGMLTGI
MAV_4112|M.avium_104 LLMWSNHLVASPHWAADNQTWPTTLWASN--PTISAAIQFGPVGGMLTGL
Mflv_3580|M.gilvum_PYR-GCK ALVLSTEFLASDQWALDNQSWPTTLWATN--ATISAAILSGPVAGMLAGL
Mvan_2835|M.vanbaalenii_PYR-1 ALMLSTEFVASDQWALDNQSWPTTLWATN--ATISAAILSGPVSGMLAGL
MSMEG_3239|M.smegmatis_MC2_155 ALMLSTELVASEQWIADNQSWPTTLWATN--ATISVALHFGPIGGMSAGL
TH_1288|M.thermoresistible__bu ALMLATGLIADAAWVADNQSLPTTLWATN--ATISAAIQFGPVRGMLTGV
MAB_4520c|M.abscessus_ATCC_199 ALMLAGRLVVDVQWYSGHQTLPTTLWVAN--AVVSMGLLRGQLAGVISGF
Mb0781|M.bovis_AF2122/97 TALNDNTAIPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTTV
Rv0758|M.tuberculosis_H37Rv TALNDNTAIPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTTV
MUL_0464|M.ulcerans_Agy99 TAINDRNAEPALPADNDVGSDPTTLPSVNGSNIEWRAVSVHGPQGGLTTV
: . **** . .: * : .
MMAR_3958|M.marinum_M AVTAANEAVKGYVNVNLGRSATIVIELAVGLAVGMAARTARRAHADLQRA
MAV_4112|M.avium_104 AVMTANFAVKNYFALNLGHNATVIIELAIGMAIGMAAQTARRAHDELQRA
Mflv_3580|M.gilvum_PYR-GCK AVVAAGAALKGYVSIDLGRNATIVIELAVGLAVGMAAQTARRAHAELERA
Mvan_2835|M.vanbaalenii_PYR-1 VVVAASAALKGYVSIDLGRNATVVIELAVGLAVGMAAQTARRAHAELERA
MSMEG_3239|M.smegmatis_MC2_155 AVMATVALLKGHVSVNLGRNATIVIELAVGLAVGMAAQTARRAHAELERA
TH_1288|M.thermoresistible__bu AVMLAAAALKGHISINLGRNATIVIELAVGLAVGMAAQTARRAHAELRRA
MAB_4520c|M.abscessus_ATCC_199 VLAAVSIAARGLPVSALWLDATMPALVVVGLAIGAASTTAKRTFHELRRA
Mb0781|M.bovis_AF2122/97 AIDLADVRSTVRSLVLLQVGIGSAVLVVLGVAGYAVVRRSLRPLAEFEQT
Rv0758|M.tuberculosis_H37Rv AIDLADVRSTVRSLVLLQVGIGSAVLVVPGVAGYAVVRRSLRPLAEFEQT
MUL_0464|M.ulcerans_Agy99 AIDLSDVQHTVRSLVWLQIGIGAGVLVVVGLAGFAVVQRSLRPLSEVEQT
.: * . :. *:* . : *. :..::
MMAR_3958|M.marinum_M AQLSAALQERERLSRQVHDGVIQVLALVSR----RGHEIGGPTSELAELA
MAV_4112|M.avium_104 ARLTAAAQERDRLARQVHDGAIQVLALVAK----KGHEIGGATTELADLA
Mflv_3580|M.gilvum_PYR-GCK TRLAASLEERERLSRQVHDGAIQVLALVAR----RGREIGGDTAQLAELA
Mvan_2835|M.vanbaalenii_PYR-1 ARLSASLEERERLSRQVHDGAIQVLALVAR----RGREIGGDTAQLAELA
MSMEG_3239|M.smegmatis_MC2_155 VRLSAALEERERLSRRVHDGAIQVLALVAR----RGREIGGETAKLAELA
TH_1288|M.thermoresistible__bu ARLAAVTEERERLSRQVHDGAIQVLALVAR----RGREIGGEVTELAELA
MAB_4520c|M.abscessus_ATCC_199 ERAAAAAIERERLSRQVHDGVLQVLSYVKR----RGTEIGGPTAELAAIA
Mb0781|M.bovis_AF2122/97 AAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSAEKA
Rv0758|M.tuberculosis_H37Rv AAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSAEKA
MUL_0464|M.ulcerans_Agy99 AAAIASGQLDRRVPERDPRTEVGQLSLAMNGMLSQIQVALAASEDSAEKA
. *:.. : *: . . : . . * *
MMAR_3958|M.marinum_M SEQERALRRWIISTDTDRDG-------------NTRSVDLCALLRRRASD
MAV_4112|M.avium_104 SEQERALRRWLACTDIDRDA-------------DGDTVDLRTLLRRRESD
Mflv_3580|M.gilvum_PYR-GCK GEQERALRRLVSAADTPHR--------------AGATADLGAMLRSRASD
Mvan_2835|M.vanbaalenii_PYR-1 GEQERALRRLVSANDAEPR--------------KGAMSDIGAMLRRRATD
MSMEG_3239|M.smegmatis_MC2_155 GEQERALRRLVSAADTDTM--------------AGPLTDVGALLRTRASD
TH_1288|M.thermoresistible__bu GEQERALRRLVSATESAPGG-------------ADHTVDVATLLRRRACD
MAB_4520c|M.abscessus_ATCC_199 GEQEIALRELISGATQTTLA-------------DDELVDLRPLLRTQAST
Mb0781|M.bovis_AF2122/97 RDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLSRIESE
Rv0758|M.tuberculosis_H37Rv RDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLSRIESE
MUL_0464|M.ulcerans_Agy99 RSSEERMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLSRIESE
..* :*. : *: :*
MMAR_3958|M.marinum_M RVSMSLPGTPVTLTREVAT-------------------------------
MAV_4112|M.avium_104 RVSISLPGTPVRLGRWAAT-------------------------------
Mflv_3580|M.gilvum_PYR-GCK RVSVSVPAEPVLLDSAVAT-------------------------------
Mvan_2835|M.vanbaalenii_PYR-1 RVSISVPADPVLLDATVAD-------------------------------
MSMEG_3239|M.smegmatis_MC2_155 RVSVSVPAEPVLLDHPVAR-------------------------------
TH_1288|M.thermoresistible__bu RVTMSLPGTPVPMDADVAA-------------------------------
MAB_4520c|M.abscessus_ATCC_199 TVSVSAPGAPVLIGQHMAS-------------------------------
Mb0781|M.bovis_AF2122/97 ASRMGLLVDDLLLLARLDAHRPLELCRVDLLALASDAAHDARAMDPKRRI
Rv0758|M.tuberculosis_H37Rv ASRMGLLVDDLLLLARLDAHRPLELCRVDLLALASDAAHDARAMDPKRRI
MUL_0464|M.ulcerans_Agy99 ASRMGLLVDDLLTLARLDVQRPLERNRVDLLVLAADAVHDARAIDRKRAI
:. :
MMAR_3958|M.marinum_M ------------------ELDAAVGNALDNVRLHAGPSARAFVLLEDLGD
MAV_4112|M.avium_104 ------------------ELDAAVGNALDNVVAHAGPGAHAFVLVEDLGD
Mflv_3580|M.gilvum_PYR-GCK ------------------EFFAAVTNALDNAEAHAGPHARVYVLLEDLGD
Mvan_2835|M.vanbaalenii_PYR-1 ------------------ELLAAVTNALDNVEAHAGPVARAYVLLEDLGA
MSMEG_3239|M.smegmatis_MC2_155 ------------------ELFAAAENALDNVAAHAGADARAFVLLEDLGE
TH_1288|M.thermoresistible__bu ------------------ELDAAVGNALDNVALHAGPDARAFVLVEDLGD
MAB_4520c|M.abscessus_ATCC_199 ------------------ELAAVVRSALSNVALHAGPQAHAYVLIEDLVD
Mb0781|M.bovis_AF2122/97 TLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEGD
Rv0758|M.tuberculosis_H37Rv TLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEGD
MUL_0464|M.ulcerans_Agy99 TVEVLEGPGTPEVLGDEPRLRQVLSNLVGNALQHTPDSADVTVRVGTAGE
.: . . : *. *: * . * :
MMAR_3958|M.marinum_M SVTVSVRDDGVGIAP------------GRLDEAAGQGHLGISKSIVG-RL
MAV_4112|M.avium_104 SVLVSVRDDGVGIAA------------GRVEEAARQGRLGISQSIVG-RL
Mflv_3580|M.gilvum_PYR-GCK SVTVSVRDDGVGIPE------------GRLEAAVGEGRVGVAKSIVG-RM
Mvan_2835|M.vanbaalenii_PYR-1 TVTVTVRDDGVGIPE------------GRLDEAVTEGRVGVSKSIVG-RM
MSMEG_3239|M.smegmatis_MC2_155 EVTVSIRDDGVGIPE------------GRLAEAERQGRMGVAKSIVG-RM
TH_1288|M.thermoresistible__bu TVTVSIRDDGAGIAP------------GRLDEAVREGRMGIAKSIVG-RM
MAB_4520c|M.abscessus_ATCC_199 SVVVTVRDDGSGIAD------------GRLDQAEREGRMGVSRSILG-RV
Mb0781|M.bovis_AF2122/97 DAILEVADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDSLV
Rv0758|M.tuberculosis_H37Rv DAILEVADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDSLV
MUL_0464|M.ulcerans_Agy99 NAVLEVADKGPGMPAEDAARVFERFYRTDSSRARASGGTGLGLSIVHSLV
. : : *.* *:. * .* *:. **: :
MMAR_3958|M.marinum_M AALGGTAELSTDQGEGTEWELRVPRREGSS------------
MAV_4112|M.avium_104 ASLGGTAELHSEPGAGTEWELCVPRREGRDDG----------
Mflv_3580|M.gilvum_PYR-GCK NWLGGRAELATGPGVGTEWELTVPR-----------------
Mvan_2835|M.vanbaalenii_PYR-1 DWLGGRAELSTGPGMGTEWELTVSR-----------------
MSMEG_3239|M.smegmatis_MC2_155 DWLGGTAVLTTGPDSGTEWELTVPRTRKGQ------------
TH_1288|M.thermoresistible__bu ESLGGEAVLTTS-ERGTEWELTVPRKDGRHG-----------
MAB_4520c|M.abscessus_ATCC_199 ADLGGAVLLETGPGAGTEWEITVPKSQEVGA-----------
Mb0781|M.bovis_AF2122/97 AAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLSLTPVVPGPP
Rv0758|M.tuberculosis_H37Rv AAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLSLTPVVPGPP
MUL_0464|M.ulcerans_Agy99 KAHGGDVTLTTAPGEGCCFRVTLPRVSEAAVELTEPVS----
** . : : * :.: :.: