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VAGVAGGLADHLDVPVFRVRLAFAVLGAASGMGIVAYGLLWMLMPPGDDVAAVSATDRRRATGLLLLSLA ALIILMSTVSGSAASLVFPTVLALTGLAVVWREFDAQGPSLAVLGAPGRPSMLTLVRVVAGAALVFGGIA VVVLRNVDLSSLRDSLVAIAATLVGAVLLTVPLWLRLWRALGIERAARIRTEERDEIASHLHDSVLQTLA LIQKRTDNPSEVLRLARSQERELRSWLFSAGAASDSSLAQELRAVAGEVEDTHTVAVSPVIVGDADLALE PETGRALVGATREALVNAAKHSGQSDINLYAEVEPGQISVFVRDRGKGFDPEEVPQDRQGIARSIKARVL RRGGQVQIKSEIGKGTEVRIIMPYKANDVDEKEQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3715c | - | - | 100% (385) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_4520c | - | 2e-12 | 29.28% (263) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_0061 | - | 1e-10 | 23.93% (326) | two component sensor kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 6e-06 | 26.73% (202) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_3580 | - | 4e-14 | 28.93% (280) | putative signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3132c | devS | 6e-06 | 26.73% (202) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_3958 | - | 3e-15 | 29.64% (280) | two-component sensor kinase |
| M. avium 104 | MAV_4112 | - | 8e-13 | 30.88% (204) | hypothetical protein MAV_4112 |
| M. smegmatis MC2 155 | MSMEG_3239 | - | 1e-12 | 26.73% (333) | two-component system sensor kinase |
| M. thermoresistible (build 8) | TH_1288 | - | 4e-15 | 29.18% (329) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_2422 | devS | 1e-05 | 25.67% (335) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_2835 | - | 3e-12 | 30.80% (276) | putative signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3580|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2835|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3239|M.smegmatis_MC2_155 --------------------------------------------------
TH_1288|M.thermoresistible__bu --------------------------------------------------
MMAR_3958|M.marinum_M --------------------------------------------------
MAV_4112|M.avium_104 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
Rv3132c|M.tuberculosis_H37Rv -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MAB_3715c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3580|M.gilvum_PYR-GCK --------------------------------------MWRAAQVF----
Mvan_2835|M.vanbaalenii_PYR-1 ------------------------------MTPDPATPLWRAAQVF----
MSMEG_3239|M.smegmatis_MC2_155 ----------------------------MQREPDPVTPLWRAAQGF----
TH_1288|M.thermoresistible__bu ---------------------------MAAERVDPATPLWRAAQVF----
MMAR_3958|M.marinum_M ---------------------------MATRGPDPTAPLWRAAQLF----
MAV_4112|M.avium_104 -----------------------MLTTMANHGPDPTTPLWRAAQVF----
Mb3156c|M.bovis_AF2122/97 GRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQH
Rv3132c|M.tuberculosis_H37Rv GRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQH
MUL_2422|M.ulcerans_Agy99 GRDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRDK
MAB_3715c|M.abscessus_ATCC_199 ------------------------------MVAGVAGGLADHLDVPVFRV
:
Mflv_3580|M.gilvum_PYR-GCK RLLSCVYA-----------------------------------FGFQLAV
Mvan_2835|M.vanbaalenii_PYR-1 RLLSCIYA-----------------------------------FGFQLAV
MSMEG_3239|M.smegmatis_MC2_155 RLLSCLYA-----------------------------------LGFHIAI
TH_1288|M.thermoresistible__bu RLLSCLYA-----------------------------------VGFQIAV
MMAR_3958|M.marinum_M RLLSCGYA-----------------------------------LGFHIAI
MAV_4112|M.avium_104 RLLSCLYA-----------------------------------TGFQIAI
Mb3156c|M.bovis_AF2122/97 RVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASI
Rv3132c|M.tuberculosis_H37Rv RVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASI
MUL_2422|M.ulcerans_Agy99 RVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQHPASI
MAB_3715c|M.abscessus_ATCC_199 RLAFAVLG---------------------------------------AAS
*: :
Mflv_3580|M.gilvum_PYR-GCK NADLESPVAGWVLFGALLAWSLACAVAYLQGFGRRLSWVLAEVAVVIALV
Mvan_2835|M.vanbaalenii_PYR-1 NPDLEHPVGGWVLFAVLIGWSAACATAYLQGFGRRPAWVLAEIVVVVALM
MSMEG_3239|M.smegmatis_MC2_155 TDDLRRPVLGWVLFAGLIVWSAACATVYLTGSRRRGTWVIAELVVVVALM
TH_1288|M.thermoresistible__bu NGDLRHPAAGWLMLAVLLAWSAACAVGYLNGFARRPGWVIAEIVVVIALM
MMAR_3958|M.marinum_M NANLQRPLLGWALFAVLIGWSAACAVAYLRGFGRRPAWVITEIAVVVVLM
MAV_4112|M.avium_104 NPDLLRPVLGWVLFAGLIGWSAACALAYLRGFGRKPAWVLAELVVVVLLM
Mb3156c|M.bovis_AF2122/97 GFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALA
Rv3132c|M.tuberculosis_H37Rv GFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALA
MUL_2422|M.ulcerans_Agy99 GFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQALA
MAB_3715c|M.abscessus_ATCC_199 GMGIVAYGLLWMLMPPGDDVAAVSATDRRRATG-LLLLSLAALIILMSTV
: . ::
Mflv_3580|M.gilvum_PYR-GCK LSTEFLASDQWALDNQSWPTTLWATNATISAAILSG--------------
Mvan_2835|M.vanbaalenii_PYR-1 LSTEFVASDQWALDNQSWPTTLWATNATISAAILSG--------------
MSMEG_3239|M.smegmatis_MC2_155 LSTELVASEQWIADNQSWPTTLWATNATISVALHFG--------------
TH_1288|M.thermoresistible__bu LATGLIADAAWVADNQSLPTTLWATNATISAAIQFG--------------
MMAR_3958|M.marinum_M LSTKMVASAQWALDNQTWPTTLWASNATISAALQFG--------------
MAV_4112|M.avium_104 WSNHLVASPHWAADNQTWPTTLWASNPTISAAIQFG--------------
Mb3156c|M.bovis_AF2122/97 AAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEA
Rv3132c|M.tuberculosis_H37Rv AAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEA
MUL_2422|M.ulcerans_Agy99 AAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPASVFRLVAEEA
MAB_3715c|M.abscessus_ATCC_199 SGSAASLVFPTVLALTGLAVVWREFDAQGPSLAVLG--------------
. . *
Mflv_3580|M.gilvum_PYR-GCK -------------------PVAGMLAGLAVVAAGAALKGYVSIDLGRNAT
Mvan_2835|M.vanbaalenii_PYR-1 -------------------PVSGMLAGLVVVAASAALKGYVSIDLGRNAT
MSMEG_3239|M.smegmatis_MC2_155 -------------------PIGGMSAGLAVMATVALLKGHVSVNLGRNAT
TH_1288|M.thermoresistible__bu -------------------PVRGMLTGVAVMLAAAALKGHISINLGRNAT
MMAR_3958|M.marinum_M -------------------PAGGMLTGIAVTAANEAVKGYVNVNLGRSAT
MAV_4112|M.avium_104 -------------------PVGGMLTGLAVMTANFAVKNYFALNLGHNAT
Mb3156c|M.bovis_AF2122/97 LKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASTVGRTIPVAGA
Rv3132c|M.tuberculosis_H37Rv LKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGA
MUL_2422|M.ulcerans_Agy99 LKLTSADAALVAIPVDEDVPASEVAQLLVIETVGNAVAAAEGCTIAVAGT
MAB_3715c|M.abscessus_ATCC_199 -----------APGRPSMLTLVRVVAGAALVFGGIAVVVLRNVDLSSLRD
. : .: : :
Mflv_3580|M.gilvum_PYR-GCK IVIELAVG------------------------------------------
Mvan_2835|M.vanbaalenii_PYR-1 VVIELAVG------------------------------------------
MSMEG_3239|M.smegmatis_MC2_155 IVIELAVG------------------------------------------
TH_1288|M.thermoresistible__bu IVIELAVG------------------------------------------
MMAR_3958|M.marinum_M IVIELAVG------------------------------------------
MAV_4112|M.avium_104 VIIELAIG------------------------------------------
Mb3156c|M.bovis_AF2122/97 VLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLS
Rv3132c|M.tuberculosis_H37Rv VLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLS
MUL_2422|M.ulcerans_Agy99 ALAEVLLDSAPRQVDKIAVEDVDELGDMGPALVLPLRATDAVAGVVVLLH
MAB_3715c|M.abscessus_ATCC_199 SLVAIAATLVG---------------------------------------
: :
Mflv_3580|M.gilvum_PYR-GCK --------------LAVGMAAQTARRAHAELERATRLAASLEERERLSRQ
Mvan_2835|M.vanbaalenii_PYR-1 --------------LAVGMAAQTARRAHAELERAARLSASLEERERLSRQ
MSMEG_3239|M.smegmatis_MC2_155 --------------LAVGMAAQTARRAHAELERAVRLSAALEERERLSRR
TH_1288|M.thermoresistible__bu --------------LAVGMAAQTARRAHAELRRAARLAAVTEERERLSRQ
MMAR_3958|M.marinum_M --------------LAVGMAARTARRAHADLQRAAQLSAALQERERLSRQ
MAV_4112|M.avium_104 --------------MAIGMAAQTARRAHDELQRAARLTAAAQERDRLARQ
Mb3156c|M.bovis_AF2122/97 QGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARD
Rv3132c|M.tuberculosis_H37Rv QGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARD
MUL_2422|M.ulcerans_Agy99 PSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTERDRIARD
MAB_3715c|M.abscessus_ATCC_199 ---------------AVLLTVPLWLRLWRALGIERAARIRTEERDEIASH
* :*:.::
Mflv_3580|M.gilvum_PYR-GCK VHDGAIQVLALVARRGR-------------EIGGDTAQLAELAGEQERAL
Mvan_2835|M.vanbaalenii_PYR-1 VHDGAIQVLALVARRGR-------------EIGGDTAQLAELAGEQERAL
MSMEG_3239|M.smegmatis_MC2_155 VHDGAIQVLALVARRGR-------------EIGGETAKLAELAGEQERAL
TH_1288|M.thermoresistible__bu VHDGAIQVLALVARRGR-------------EIGGEVTELAELAGEQERAL
MMAR_3958|M.marinum_M VHDGVIQVLALVSRRGH-------------EIGGPTSELAELASEQERAL
MAV_4112|M.avium_104 VHDGAIQVLALVAKKGH-------------EIGGATTELADLASEQERAL
Mb3156c|M.bovis_AF2122/97 LHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTI
Rv3132c|M.tuberculosis_H37Rv LHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTI
MUL_2422|M.ulcerans_Agy99 LHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGVIQEIRTTI
MAB_3715c|M.abscessus_ATCC_199 LHDSVLQTLALIQKRTD-----------------NPSEVLRLARSQEREL
:** .:* * : .: : . . :
Mflv_3580|M.gilvum_PYR-GCK RRLVSAADTPHR----AGATADLGAMLRSRASDRVSVSVPAEPVLLDSAV
Mvan_2835|M.vanbaalenii_PYR-1 RRLVSANDAEPR----KGAMSDIGAMLRRRATDRVSISVPADPVLLDATV
MSMEG_3239|M.smegmatis_MC2_155 RRLVSAADTDTM----AGPLTDVGALLRTRASDRVSVSVPAEPVLLDHPV
TH_1288|M.thermoresistible__bu RRLVSATESAPGG---ADHTVDVATLLRRRACDRVTMSLPGTPVPMDADV
MMAR_3958|M.marinum_M RRWIISTDTDRDG---NTRSVDLCALLRRRASDRVSMSLPGTPVTLTREV
MAV_4112|M.avium_104 RRWLACTDIDRDA---DGDTVDLRTLLRRRESDRVSISLPGTPVRLGRWA
Mb3156c|M.bovis_AF2122/97 YDLHGASQGITR----LRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSAL
Rv3132c|M.tuberculosis_H37Rv YDLHGASQGITR----LRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSAL
MUL_2422|M.ulcerans_Agy99 FDLHGSSQGVTR----LRQRIDAAVAAFGSSGLRTTVQFIGPLSVVDNVL
MAB_3715c|M.abscessus_ATCC_199 RSWLFSAGAASDSSLAQELRAVAGEVEDTHTVAVSPVIVGDADLALEPET
. .: . :
Mflv_3580|M.gilvum_PYR-GCK ATEFFAAVTNALDNAEAHAGPHARVYVLLEDLGDSVTVSVRDDGVGIPEG
Mvan_2835|M.vanbaalenii_PYR-1 ADELLAAVTNALDNVEAHAGPVARAYVLLEDLGATVTVTVRDDGVGIPEG
MSMEG_3239|M.smegmatis_MC2_155 ARELFAAAENALDNVAAHAGADARAFVLLEDLGEEVTVSIRDDGVGIPEG
TH_1288|M.thermoresistible__bu AAELDAAVGNALDNVALHAGPDARAFVLVEDLGDTVTVSIRDDGAGIAPG
MMAR_3958|M.marinum_M ATELDAAVGNALDNVRLHAGPSARAFVLLEDLGDSVTVSVRDDGVGIAPG
MAV_4112|M.avium_104 ATELDAAVGNALDNVVAHAGPGAHAFVLVEDLGDSVLVSVRDDGVGIAAG
Mb3156c|M.bovis_AF2122/97 ADQAEAVVREAVSNAVRHA--KASTLTVRVKVDDDLCIEVTDNGRGLPDE
Rv3132c|M.tuberculosis_H37Rv ADQAEAVVREAVSNAVRHA--KASTLTVRVKVDDDLCIEVTDNGRGLPDE
MUL_2422|M.ulcerans_Agy99 ADHAEAVVREAVSNAVRHA--QATTLTVRVKVDDDLCIEVSDNGRGMPKT
MAB_3715c|M.abscessus_ATCC_199 GRALVGATREALVNAAKHSGQSDINLYAEVEPGQ-ISVFVRDRGKGFDP-
. ... :*: *. *: . . : : : * * *:
Mflv_3580|M.gilvum_PYR-GCK RLEAAVGEGRVGVAKSIVGRMNWLGGRAELATGP-GVGTEWELTVPR---
Mvan_2835|M.vanbaalenii_PYR-1 RLDEAVTEGRVGVSKSIVGRMDWLGGRAELSTGP-GMGTEWELTVSR---
MSMEG_3239|M.smegmatis_MC2_155 RLAEAERQGRMGVAKSIVGRMDWLGGTAVLTTGP-DSGTEWELTVPRTRK
TH_1288|M.thermoresistible__bu RLDEAVREGRMGIAKSIVGRMESLGGEAVLTTS--ERGTEWELTVPRKDG
MMAR_3958|M.marinum_M RLDEAAGQGHLGISKSIVGRLAALGGTAELSTDQ-GEGTEWELRVPRREG
MAV_4112|M.avium_104 RVEEAARQGRLGISQSIVGRLASLGGTAELHSEP-GAGTEWELCVPRREG
Mb3156c|M.bovis_AF2122/97 FTGSGLTN--------LRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
Rv3132c|M.tuberculosis_H37Rv FTGSGLTN--------LRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
MUL_2422|M.ulcerans_Agy99 YTSSGLTN--------LRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ-
MAB_3715c|M.abscessus_ATCC_199 ---EEVPQDRQGIARSIKARVLRRGGQVQIKSEI-GKGTEVRIIMPYKAN
: : * ** : : ** . .
Mflv_3580|M.gilvum_PYR-GCK -------
Mvan_2835|M.vanbaalenii_PYR-1 -------
MSMEG_3239|M.smegmatis_MC2_155 GQ-----
TH_1288|M.thermoresistible__bu RHG----
MMAR_3958|M.marinum_M SS-----
MAV_4112|M.avium_104 RDDG---
Mb3156c|M.bovis_AF2122/97 -------
Rv3132c|M.tuberculosis_H37Rv -------
MUL_2422|M.ulcerans_Agy99 -------
MAB_3715c|M.abscessus_ATCC_199 DVDEKEQ