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VTPDPATPLWRAAQVFRLLSCIYAFGFQLAVNPDLEHPVGGWVLFAVLIGWSAACATAYLQGFGRRPAWV LAEIVVVVALMLSTEFVASDQWALDNQSWPTTLWATNATISAAILSGPVSGMLAGLVVVAASAALKGYVS IDLGRNATVVIELAVGLAVGMAAQTARRAHAELERAARLSASLEERERLSRQVHDGAIQVLALVARRGRE IGGDTAQLAELAGEQERALRRLVSANDAEPRKGAMSDIGAMLRRRATDRVSISVPADPVLLDATVADELL AAVTNALDNVEAHAGPVARAYVLLEDLGATVTVTVRDDGVGIPEGRLDEAVTEGRVGVSKSIVGRMDWLG GRAELSTGPGMGTEWELTVSR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2835 | - | - | 100% (371) | putative signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_1421 | - | 2e-07 | 25.11% (231) | ATPase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1413 | - | 2e-06 | 22.93% (266) | GAF sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_3580 | - | 1e-175 | 85.12% (363) | putative signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0845 | - | 4e-05 | 23.31% (296) | two component sensor kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4520c | - | 3e-90 | 49.73% (370) | putative two-component system sensor kinase |
| M. marinum M | MMAR_3958 | - | 1e-145 | 70.54% (370) | two-component sensor kinase |
| M. avium 104 | MAV_4112 | - | 1e-139 | 67.57% (370) | hypothetical protein MAV_4112 |
| M. smegmatis MC2 155 | MSMEG_3239 | - | 1e-157 | 76.15% (369) | two-component system sensor kinase |
| M. thermoresistible (build 8) | TH_1288 | - | 1e-147 | 72.36% (369) | two-component system sensor kinase |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2835|M.vanbaalenii_PYR-1 ------------------------------MTPDPATPLWRAAQVFRLLS
Mflv_3580|M.gilvum_PYR-GCK --------------------------------------MWRAAQVFRLLS
MSMEG_3239|M.smegmatis_MC2_155 ----------------------------MQREPDPVTPLWRAAQGFRLLS
TH_1288|M.thermoresistible__bu ---------------------------MAAERVDPATPLWRAAQVFRLLS
MMAR_3958|M.marinum_M ---------------------------MATRGPDPTAPLWRAAQLFRLLS
MAV_4112|M.avium_104 -----------------------MLTTMANHGPDPTTPLWRAAQVFRLLS
MAB_4520c|M.abscessus_ATCC_199 ------------------MGSKNGTVPRWMSGSDPTASLWRAAQVFRLAS
Rv0845|M.tuberculosis_H37Rv MPSYGNLGRLGGRHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGV
:* *. :*:
Mvan_2835|M.vanbaalenii_PYR-1 CIYAFG-FQLAVN-PDLEHPVGGWVLFAVLIGWSAACATAYLQGFGRRPA
Mflv_3580|M.gilvum_PYR-GCK CVYAFG-FQLAVN-ADLESPVAGWVLFGALLAWSLACAVAYLQGFGRRLS
MSMEG_3239|M.smegmatis_MC2_155 CLYALG-FHIAIT-DDLRRPVLGWVLFAGLIVWSAACATVYLTGSRRRGT
TH_1288|M.thermoresistible__bu CLYAVG-FQIAVN-GDLRHPAAGWLMLAVLLAWSAACAVGYLNGFARRPG
MMAR_3958|M.marinum_M CGYALG-FHIAIN-ANLQRPLLGWALFAVLIGWSAACAVAYLRGFGRRPA
MAV_4112|M.avium_104 CLYATG-FQIAIN-PDLLRPVLGWVLFAGLIGWSAACALAYLRGFGRKPA
MAB_4520c|M.abscessus_ATCC_199 FGYALLASQLASY-TNYERQGLSWALYAVMAMWTGFAAVALSRNWFRRWQ
Rv0845|M.tuberculosis_H37Rv VGLMVAAMVVGTSRSEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRR
:. : : . *: *
Mvan_2835|M.vanbaalenii_PYR-1 WVLAEIVVVVALMLSTEFVAS-DQWALDNQSWPTTLWATNATISAAILSG
Mflv_3580|M.gilvum_PYR-GCK WVLAEVAVVIALVLSTEFLAS-DQWALDNQSWPTTLWATNATISAAILSG
MSMEG_3239|M.smegmatis_MC2_155 WVIAELVVVVALMLSTELVAS-EQWIADNQSWPTTLWATNATISVALHFG
TH_1288|M.thermoresistible__bu WVIAEIVVVIALMLATGLIAD-AAWVADNQSLPTTLWATNATISAAIQFG
MMAR_3958|M.marinum_M WVITEIAVVVVLMLSTKMVAS-AQWALDNQTWPTTLWASNATISAALQFG
MAV_4112|M.avium_104 WVLAELVVVVLLMWSNHLVAS-PHWAADNQTWPTTLWASNPTISAAIQFG
MAB_4520c|M.abscessus_ATCC_199 LVLCDQAIVIALMLAGRLVVD-VQWYSGHQTLPTTLWVANAVVSMGLLRG
Rv0845|M.tuberculosis_H37Rv FRSMGRLEPFAFTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVST
. : :: . * : ..:
Mvan_2835|M.vanbaalenii_PYR-1 PVSGMLAGLVVVAASAALKG--YVSIDLGRNATVVIELAVGLAVGMAAQT
Mflv_3580|M.gilvum_PYR-GCK PVAGMLAGLAVVAAGAALKG--YVSIDLGRNATIVIELAVGLAVGMAAQT
MSMEG_3239|M.smegmatis_MC2_155 PIGGMSAGLAVMATVALLKG--HVSVNLGRNATIVIELAVGLAVGMAAQT
TH_1288|M.thermoresistible__bu PVRGMLTGVAVMLAAAALKG--HISINLGRNATIVIELAVGLAVGMAAQT
MMAR_3958|M.marinum_M PAGGMLTGIAVTAANEAVKG--YVNVNLGRSATIVIELAVGLAVGMAART
MAV_4112|M.avium_104 PVGGMLTGLAVMTANFAVKN--YFALNLGHNATVIIELAIGMAIGMAAQT
MAB_4520c|M.abscessus_ATCC_199 QLAGVISGFVLAAVSIAARG--LPVSALWLDATMPALVVVGLAIGAASTT
Rv0845|M.tuberculosis_H37Rv RRAAVVLACTLVGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMV
.: . .: . : *: .: . * .
Mvan_2835|M.vanbaalenii_PYR-1 ARRAHAELERAARLSASLEE------------RERLSRQVHDGAIQVLAL
Mflv_3580|M.gilvum_PYR-GCK ARRAHAELERATRLAASLEE------------RERLSRQVHDGAIQVLAL
MSMEG_3239|M.smegmatis_MC2_155 ARRAHAELERAVRLSAALEE------------RERLSRRVHDGAIQVLAL
TH_1288|M.thermoresistible__bu ARRAHAELRRAARLAAVTEE------------RERLSRQVHDGAIQVLAL
MMAR_3958|M.marinum_M ARRAHADLQRAAQLSAALQE------------RERLSRQVHDGVIQVLAL
MAV_4112|M.avium_104 ARRAHDELQRAARLTAAAQE------------RDRLARQVHDGAIQVLAL
MAB_4520c|M.abscessus_ATCC_199 AKRTFHELRRAERAAAAAIE------------RERLSRQVHDGVLQVLSY
Rv0845|M.tuberculosis_H37Rv VRIEERHTRSVAGLSALRAELLAQTMTASEVLQRRIAEAIHDGPLQDVLA
.: . . . :* * : *::. :*** :* :
Mvan_2835|M.vanbaalenii_PYR-1 VARRGREIGGDT---AQLAELAGEQERALRRLVSANDAEPR-KGAMSDIG
Mflv_3580|M.gilvum_PYR-GCK VARRGREIGGDT---AQLAELAGEQERALRRLVSAADTPHR-AGATADLG
MSMEG_3239|M.smegmatis_MC2_155 VARRGREIGGET---AKLAELAGEQERALRRLVSAADTDTM-AGPLTDVG
TH_1288|M.thermoresistible__bu VARRGREIGGEV---TELAELAGEQERALRRLVSATESAPGGADHTVDVA
MMAR_3958|M.marinum_M VSRRGHEIGGPT---SELAELASEQERALRRWIISTDTDRDGNTRSVDLC
MAV_4112|M.avium_104 VAKKGHEIGGAT---TELADLASEQERALRRWLACTDIDRDADGDTVDLR
MAB_4520c|M.abscessus_ATCC_199 VKRRGTEIGGPT---AELAAIAGEQEIALRELISGATQTTLADDELVDLR
Rv0845|M.tuberculosis_H37Rv ARQELIELDAVTPGDERVGRALAGLQSASERLRQATFELHPAVLEQVGLG
. :. *:.. . .:. . : * .. .:
Mvan_2835|M.vanbaalenii_PYR-1 AMLRRRATDRVSIS----VPADPVLLDATVADELLAAVTNALDNVEAHAG
Mflv_3580|M.gilvum_PYR-GCK AMLRSRASDRVSVS----VPAEPVLLDSAVATEFFAAVTNALDNAEAHAG
MSMEG_3239|M.smegmatis_MC2_155 ALLRTRASDRVSVS----VPAEPVLLDHPVARELFAAAENALDNVAAHAG
TH_1288|M.thermoresistible__bu TLLRRRACDRVTMS----LPGTPVPMDADVAAELDAAVGNALDNVALHAG
MMAR_3958|M.marinum_M ALLRRRASDRVSMS----LPGTPVTLTREVATELDAAVGNALDNVRLHAG
MAV_4112|M.avium_104 TLLRRRESDRVSIS----LPGTPVRLGRWAATELDAAVGNALDNVVAHAG
MAB_4520c|M.abscessus_ATCC_199 PLLRTQASTTVSVS----APGAPVLIGQHMASELAAVVRSALSNVALHAG
Rv0845|M.tuberculosis_H37Rv PAVKQLAASTAQRSGIKISTDIDYPIRSGIDPIVFGVVRELLSNVVRHSG
. :: . * . : . ... . *.*. *:*
Mvan_2835|M.vanbaalenii_PYR-1 PVARAYVLLEDLGATVTVTVRDDGVGIPEGRLDEAVTEGRVGVSKSIVGR
Mflv_3580|M.gilvum_PYR-GCK PHARVYVLLEDLGDSVTVSVRDDGVGIPEGRLEAAVGEGRVGVAKSIVGR
MSMEG_3239|M.smegmatis_MC2_155 ADARAFVLLEDLGEEVTVSIRDDGVGIPEGRLAEAERQGRMGVAKSIVGR
TH_1288|M.thermoresistible__bu PDARAFVLVEDLGDTVTVSIRDDGAGIAPGRLDEAVREGRMGIAKSIVGR
MMAR_3958|M.marinum_M PSARAFVLLEDLGDSVTVSVRDDGVGIAPGRLDEAAGQGHLGISKSIVGR
MAV_4112|M.avium_104 PGAHAFVLVEDLGDSVLVSVRDDGVGIAAGRVEEAARQGRLGISQSIVGR
MAB_4520c|M.abscessus_ATCC_199 PQAHAYVLIEDLVDSVVVTVRDDGSGIADGRLDQAEREGRMGVSRSILGR
Rv0845|M.tuberculosis_H37Rv -ATTASVRLGITDEKCVLDVADDGVGVTGDTMARRLGEGHIGLASHRARV
: . * : : : *** *:. . : :*::*::
Mvan_2835|M.vanbaalenii_PYR-1 MDWLGGRAELSTGPGMGTEWELTVSR-------
Mflv_3580|M.gilvum_PYR-GCK MNWLGGRAELATGPGVGTEWELTVPR-------
MSMEG_3239|M.smegmatis_MC2_155 MDWLGGTAVLTTGPDSGTEWELTVPRTRKGQ--
TH_1288|M.thermoresistible__bu MESLGGEAVLTTS-ERGTEWELTVPRKDGRHG-
MMAR_3958|M.marinum_M LAALGGTAELSTDQGEGTEWELRVPRREGSS--
MAV_4112|M.avium_104 LASLGGTAELHSEPGAGTEWELCVPRREGRDDG
MAB_4520c|M.abscessus_ATCC_199 VADLGGAVLLETGPGAGTEWEITVPKSQEVGA-
Rv0845|M.tuberculosis_H37Rv DAAGGVLVFLATPRGTHVCVELPLKR-------
* . * : . *: : :