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MLTTMANHGPDPTTPLWRAAQVFRLLSCLYATGFQIAINPDLLRPVLGWVLFAGLIGWSAACALAYLRGF GRKPAWVLAELVVVVLLMWSNHLVASPHWAADNQTWPTTLWASNPTISAAIQFGPVGGMLTGLAVMTANF AVKNYFALNLGHNATVIIELAIGMAIGMAAQTARRAHDELQRAARLTAAAQERDRLARQVHDGAIQVLAL VAKKGHEIGGATTELADLASEQERALRRWLACTDIDRDADGDTVDLRTLLRRRESDRVSISLPGTPVRLG RWAATELDAAVGNALDNVVAHAGPGAHAFVLVEDLGDSVLVSVRDDGVGIAAGRVEEAARQGRLGISQSI VGRLASLGGTAELHSEPGAGTEWELCVPRREGRDDG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4112 | - | - | 100% (386) | hypothetical protein MAV_4112 |
| M. avium 104 | MAV_4108 | - | 3e-07 | 24.52% (208) | GAF family protein |
| M. avium 104 | MAV_0147 | - | 5e-07 | 27.00% (237) | sensor-type histidine kinase PrrB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | 3e-05 | 25.82% (244) | two component system response sensor kinase membrane |
| M. gilvum PYR-GCK | Mflv_3580 | - | 1e-132 | 64.84% (364) | putative signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0758 | phoR | 3e-05 | 25.82% (244) | two component system response sensor kinase membrane |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4520c | - | 2e-90 | 47.33% (374) | putative two-component system sensor kinase |
| M. marinum M | MMAR_3958 | - | 1e-161 | 74.60% (378) | two-component sensor kinase |
| M. smegmatis MC2 155 | MSMEG_3239 | - | 1e-135 | 65.87% (375) | two-component system sensor kinase |
| M. thermoresistible (build 8) | TH_1288 | - | 1e-142 | 66.23% (379) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_4559 | senX3 | 1e-06 | 28.07% (114) | two component sensor histidine kinase SenX3 |
| M. vanbaalenii PYR-1 | Mvan_2835 | - | 1e-139 | 67.57% (370) | putative signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4112|M.avium_104 -----MLTTMANHGPDPTTPLWRAAQVFRLLSCLYATG-FQIAINPDLLR
MMAR_3958|M.marinum_M ---------MATRGPDPTAPLWRAAQLFRLLSCGYALG-FHIAINANLQR
Mflv_3580|M.gilvum_PYR-GCK --------------------MWRAAQVFRLLSCVYAFG-FQLAVNADLES
Mvan_2835|M.vanbaalenii_PYR-1 ------------MTPDPATPLWRAAQVFRLLSCIYAFG-FQLAVNPDLEH
MSMEG_3239|M.smegmatis_MC2_155 ----------MQREPDPVTPLWRAAQGFRLLSCLYALG-FHIAITDDLRR
TH_1288|M.thermoresistible__bu ---------MAAERVDPATPLWRAAQVFRLLSCLYAVG-FQIAVNGDLRH
MAB_4520c|M.abscessus_ATCC_199 MGSKNGTVPRWMSGSDPTASLWRAAQVFRLASFGYALLASQLASYTNYER
Mb0781|M.bovis_AF2122/97 -------MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLT
Rv0758|M.tuberculosis_H37Rv -------MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLT
MUL_4559|M.ulcerans_Agy99 --------------MFSALLLAGVLSALALAAGVAVGARLSQRLVRRRQQ
. : : : .
MAV_4112|M.avium_104 PVLGWVLFAGLIGWSAACALAYLRGF---------GRKPAWVLAELVVVV
MMAR_3958|M.marinum_M PLLGWALFAVLIGWSAACAVAYLRGF---------GRRPAWVITEIAVVV
Mflv_3580|M.gilvum_PYR-GCK PVAGWVLFGALLAWSLACAVAYLQGF---------GRRLSWVLAEVAVVI
Mvan_2835|M.vanbaalenii_PYR-1 PVGGWVLFAVLIGWSAACATAYLQGF---------GRRPAWVLAEIVVVV
MSMEG_3239|M.smegmatis_MC2_155 PVLGWVLFAGLIVWSAACATVYLTGS---------RRRGTWVIAELVVVV
TH_1288|M.thermoresistible__bu PAAGWLMLAVLLAWSAACAVGYLNGF---------ARRPGWVIAEIVVVI
MAB_4520c|M.abscessus_ATCC_199 QGLSWALYAVMAMWTGFAAVALSRNW---------FRRWQLVLCDQAIVI
Mb0781|M.bovis_AF2122/97 SRIDRVLLEEAQIWAQITLPLAPDPYPIHNPDRPPSRFYVRVISPDGQSY
Rv0758|M.tuberculosis_H37Rv SRIDRVLLEEAQIWAQITLPLAPDPYPGHNPDRPPSRFYVRVISPDGQSY
MUL_4559|M.ulcerans_Agy99 ASTEWTGITVAQMLQRIVALMPMGVA--------------VVDSHRDVVY
*
MAV_4112|M.avium_104 LLMWSNHLVASPHWAADNQTWPTTLWASN--PTISAAIQFGPVGGMLTGL
MMAR_3958|M.marinum_M VLMLSTKMVASAQWALDNQTWPTTLWASN--ATISAALQFGPAGGMLTGI
Mflv_3580|M.gilvum_PYR-GCK ALVLSTEFLASDQWALDNQSWPTTLWATN--ATISAAILSGPVAGMLAGL
Mvan_2835|M.vanbaalenii_PYR-1 ALMLSTEFVASDQWALDNQSWPTTLWATN--ATISAAILSGPVSGMLAGL
MSMEG_3239|M.smegmatis_MC2_155 ALMLSTELVASEQWIADNQSWPTTLWATN--ATISVALHFGPIGGMSAGL
TH_1288|M.thermoresistible__bu ALMLATGLIADAAWVADNQSLPTTLWATN--ATISAAIQFGPVRGMLTGV
MAB_4520c|M.abscessus_ATCC_199 ALMLAGRLVVDVQWYSGHQTLPTTLWVAN--AVVSMGLLRGQLAGVISGF
Mb0781|M.bovis_AF2122/97 TALNDNTAIPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTTV
Rv0758|M.tuberculosis_H37Rv TALNDNTAIPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTTV
MUL_4559|M.ulcerans_Agy99 LNDRAKELGLVRDRQLDDQAWEAAQQALRG-SDVEFDLSPGKRPGGRSGL
. :: : : * : .
MAV_4112|M.avium_104 AVMTAN--FAVKNYFALNLGHNATVIIELAIGMAIGMAAQTARRAHDELQ
MMAR_3958|M.marinum_M AVTAAN--EAVKGYVNVNLGRSATIVIELAVGLAVGMAARTARRAHADLQ
Mflv_3580|M.gilvum_PYR-GCK AVVAAG--AALKGYVSIDLGRNATIVIELAVGLAVGMAAQTARRAHAELE
Mvan_2835|M.vanbaalenii_PYR-1 VVVAAS--AALKGYVSIDLGRNATVVIELAVGLAVGMAAQTARRAHAELE
MSMEG_3239|M.smegmatis_MC2_155 AVMATV--ALLKGHVSVNLGRNATIVIELAVGLAVGMAAQTARRAHAELE
TH_1288|M.thermoresistible__bu AVMLAA--AALKGHISINLGRNATIVIELAVGLAVGMAAQTARRAHAELR
MAB_4520c|M.abscessus_ATCC_199 VLAAVS--IAARGLPVSALWLDATMPALVVVGLAIGAASTTAKRTFHELR
Mb0781|M.bovis_AF2122/97 AIDLAD--VRSTVRSLVLLQVGIGSAVLVVLGVAGYAVVRRSLRPLAEFE
Rv0758|M.tuberculosis_H37Rv AIDLAD--VRSTVRSLVLLQVGIGSAVLVVPGVAGYAVVRRSLRPLAEFE
MUL_4559|M.ulcerans_Agy99 SVHGQARLLSEEDRRFTVVFAYDQSDYARMEATRRDFVANVSHELKTPVG
: : . . : . .
MAV_4112|M.avium_104 RAARLTAAAQERDRLARQVHDGAIQVLALVAK----KGHEIGGATTELAD
MMAR_3958|M.marinum_M RAAQLSAALQERERLSRQVHDGVIQVLALVSR----RGHEIGGPTSELAE
Mflv_3580|M.gilvum_PYR-GCK RATRLAASLEERERLSRQVHDGAIQVLALVAR----RGREIGGDTAQLAE
Mvan_2835|M.vanbaalenii_PYR-1 RAARLSASLEERERLSRQVHDGAIQVLALVAR----RGREIGGDTAQLAE
MSMEG_3239|M.smegmatis_MC2_155 RAVRLSAALEERERLSRRVHDGAIQVLALVAR----RGREIGGETAKLAE
TH_1288|M.thermoresistible__bu RAARLAAVTEERERLSRQVHDGAIQVLALVAR----RGREIGGEVTELAE
MAB_4520c|M.abscessus_ATCC_199 RAERAAAAAIERERLSRQVHDGVLQVLSYVKR----RGTEIGGPTAELAA
Mb0781|M.bovis_AF2122/97 QTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSAE
Rv0758|M.tuberculosis_H37Rv QTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSAE
MUL_4559|M.ulcerans_Agy99 AMALLAEALLASADDSDTVRRFAEKVLIEANR--------LGDMVAELIE
. * . . . .
MAV_4112|M.avium_104 LASEQERALRRWLACTDIDRDA-------------DGDTVDLRTLLRRRE
MMAR_3958|M.marinum_M LASEQERALRRWIISTDTDRDG-------------NTRSVDLCALLRRRA
Mflv_3580|M.gilvum_PYR-GCK LAGEQERALRRLVSAADTPHR--------------AGATADLGAMLRSRA
Mvan_2835|M.vanbaalenii_PYR-1 LAGEQERALRRLVSANDAEPR--------------KGAMSDIGAMLRRRA
MSMEG_3239|M.smegmatis_MC2_155 LAGEQERALRRLVSAADTDTM--------------AGPLTDVGALLRTRA
TH_1288|M.thermoresistible__bu LAGEQERALRRLVSATESAPGG-------------ADHTVDVATLLRRRA
MAB_4520c|M.abscessus_ATCC_199 IAGEQEIALRELISGATQTTLA-------------DDELVDLRPLLRTQA
Mb0781|M.bovis_AF2122/97 KARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLSRIE
Rv0758|M.tuberculosis_H37Rv KARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLSRIE
MUL_4559|M.ulcerans_Agy99 LSRLQGAERLHNVTDVD------------------VDTIVSEAISRHKVA
: . . : .
MAV_4112|M.avium_104 SDRVSISLPGTPVRLGRWAAT-----------------------------
MMAR_3958|M.marinum_M SDRVSMSLPGTPVTLTREVAT-----------------------------
Mflv_3580|M.gilvum_PYR-GCK SDRVSVSVPAEPVLLDSAVAT-----------------------------
Mvan_2835|M.vanbaalenii_PYR-1 TDRVSISVPADPVLLDATVAD-----------------------------
MSMEG_3239|M.smegmatis_MC2_155 SDRVSVSVPAEPVLLDHPVAR-----------------------------
TH_1288|M.thermoresistible__bu CDRVTMSLPGTPVPMDADVAA-----------------------------
MAB_4520c|M.abscessus_ATCC_199 STTVSVSAPGAPVLIGQHMAS-----------------------------
Mb0781|M.bovis_AF2122/97 SEASRMGLLVDDLLLLARLDAHRPLELCRVDLLALASDAAHDARAMDPKR
Rv0758|M.tuberculosis_H37Rv SEASRMGLLVDDLLLLARLDAHRPLELCRVDLLALASDAAHDARAMDPKR
MUL_4559|M.ulcerans_Agy99 ADNAEIEVRTDSSSGLHVLGDQT---------------------------
:
MAV_4112|M.avium_104 --------------------ELDAAVGNALDNVVAHAGPGAHAFVLVEDL
MMAR_3958|M.marinum_M --------------------ELDAAVGNALDNVRLHAGPSARAFVLLEDL
Mflv_3580|M.gilvum_PYR-GCK --------------------EFFAAVTNALDNAEAHAGPHARVYVLLEDL
Mvan_2835|M.vanbaalenii_PYR-1 --------------------ELLAAVTNALDNVEAHAGPVARAYVLLEDL
MSMEG_3239|M.smegmatis_MC2_155 --------------------ELFAAAENALDNVAAHAGADARAFVLLEDL
TH_1288|M.thermoresistible__bu --------------------ELDAAVGNALDNVALHAGPDARAFVLVEDL
MAB_4520c|M.abscessus_ATCC_199 --------------------ELAAVVRSALSNVALHAGPQAHAYVLIEDL
Mb0781|M.bovis_AF2122/97 RITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTE
Rv0758|M.tuberculosis_H37Rv RITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTE
MUL_4559|M.ulcerans_Agy99 --------------------LLVTALANLVSNAIAYSSPGSPVSISRRKR
: . . : *. :: : . :
MAV_4112|M.avium_104 GDSVLVSVRDDGVGIAA------------GRVEEAARQGRLGISQSIVG-
MMAR_3958|M.marinum_M GDSVTVSVRDDGVGIAP------------GRLDEAAGQGHLGISKSIVG-
Mflv_3580|M.gilvum_PYR-GCK GDSVTVSVRDDGVGIPE------------GRLEAAVGEGRVGVAKSIVG-
Mvan_2835|M.vanbaalenii_PYR-1 GATVTVTVRDDGVGIPE------------GRLDEAVTEGRVGVSKSIVG-
MSMEG_3239|M.smegmatis_MC2_155 GEEVTVSIRDDGVGIPE------------GRLAEAERQGRMGVAKSIVG-
TH_1288|M.thermoresistible__bu GDTVTVSIRDDGAGIAP------------GRLDEAVREGRMGIAKSIVG-
MAB_4520c|M.abscessus_ATCC_199 VDSVVVTVRDDGSGIAD------------GRLDQAEREGRMGVSRSILG-
Mb0781|M.bovis_AF2122/97 GDDAILEVADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDS
Rv0758|M.tuberculosis_H37Rv GDDAILEVADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDS
MUL_4559|M.ulcerans_Agy99 GDNVEIAVTDRGIGIALEDQERVFERFFRGDKARSRATGGSGLGLAIVKH
. : : * * *:. . : * *:. :*:
MAV_4112|M.avium_104 RLASLGGTAELHSEPGAGTEWELCVPRREGRDDG----------------
MMAR_3958|M.marinum_M RLAALGGTAELSTDQGEGTEWELRVPRREGSS------------------
Mflv_3580|M.gilvum_PYR-GCK RMNWLGGRAELATGPGVGTEWELTVPR-----------------------
Mvan_2835|M.vanbaalenii_PYR-1 RMDWLGGRAELSTGPGMGTEWELTVSR-----------------------
MSMEG_3239|M.smegmatis_MC2_155 RMDWLGGTAVLTTGPDSGTEWELTVPRTRKGQ------------------
TH_1288|M.thermoresistible__bu RMESLGGEAVLTTS-ERGTEWELTVPRKDGRHG-----------------
MAB_4520c|M.abscessus_ATCC_199 RVADLGGAVLLETGPGAGTEWEITVPKSQEVGA-----------------
Mb0781|M.bovis_AF2122/97 LVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLSLTPVVPGPP------
Rv0758|M.tuberculosis_H37Rv LVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLSLTPVVPGPP------
MUL_4559|M.ulcerans_Agy99 VAANHNGSIGVWSKPGTGSTFTLSIPTSSAPDDSDQPDQPRGRDARPNRS
.* : : * : : :.
MAV_4112|M.avium_104 --------
MMAR_3958|M.marinum_M --------
Mflv_3580|M.gilvum_PYR-GCK --------
Mvan_2835|M.vanbaalenii_PYR-1 --------
MSMEG_3239|M.smegmatis_MC2_155 --------
TH_1288|M.thermoresistible__bu --------
MAB_4520c|M.abscessus_ATCC_199 --------
Mb0781|M.bovis_AF2122/97 --------
Rv0758|M.tuberculosis_H37Rv --------
MUL_4559|M.ulcerans_Agy99 QREEELSR