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VQREPDPVTPLWRAAQGFRLLSCLYALGFHIAITDDLRRPVLGWVLFAGLIVWSAACATVYLTGSRRRGT WVIAELVVVVALMLSTELVASEQWIADNQSWPTTLWATNATISVALHFGPIGGMSAGLAVMATVALLKGH VSVNLGRNATIVIELAVGLAVGMAAQTARRAHAELERAVRLSAALEERERLSRRVHDGAIQVLALVARRG REIGGETAKLAELAGEQERALRRLVSAADTDTMAGPLTDVGALLRTRASDRVSVSVPAEPVLLDHPVARE LFAAAENALDNVAAHAGADARAFVLLEDLGEEVTVSIRDDGVGIPEGRLAEAERQGRMGVAKSIVGRMDW LGGTAVLTTGPDSGTEWELTVPRTRKGQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3239 | - | - | 100% (378) | two-component system sensor kinase |
| M. smegmatis MC2 155 | MSMEG_0106 | - | 2e-09 | 28.87% (239) | sensory histidine kinase |
| M. smegmatis MC2 155 | MSMEG_2248 | - | 2e-07 | 28.51% (228) | two-component system sensor kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0868 | - | 2e-06 | 25.82% (213) | two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_3580 | - | 1e-153 | 75.48% (363) | putative signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0845 | - | 2e-06 | 25.62% (242) | two component sensor kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4520c | - | 8e-90 | 48.53% (373) | putative two-component system sensor kinase |
| M. marinum M | MMAR_3958 | - | 1e-139 | 69.35% (372) | two-component sensor kinase |
| M. avium 104 | MAV_4112 | - | 1e-135 | 65.87% (375) | hypothetical protein MAV_4112 |
| M. thermoresistible (build 8) | TH_1288 | - | 1e-144 | 72.09% (369) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_0350 | - | 5e-06 | 28.57% (210) | two component sensor kinase |
| M. vanbaalenii PYR-1 | Mvan_2835 | - | 1e-157 | 76.15% (369) | putative signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3580|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2835|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3239|M.smegmatis_MC2_155 --------------------------------------------------
TH_1288|M.thermoresistible__bu --------------------------------------------------
MMAR_3958|M.marinum_M --------------------------------------------------
MAV_4112|M.avium_104 --------------------------------------------------
MAB_4520c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0868|M.bovis_AF2122/97 --------------------------------------MPSYGNLGRLGG
Rv0845|M.tuberculosis_H37Rv --------------------------------------MPSYGNLGRLGG
MUL_0350|M.ulcerans_Agy99 MMNSRQREADRRQFAPSCRRQDESAGQSLGQRRTERSPNPSCANYGQLVG
Mflv_3580|M.gilvum_PYR-GCK ---------------------------MWRAAQVFRLLSCVYAFG-FQLA
Mvan_2835|M.vanbaalenii_PYR-1 -------------------MTPDPATPLWRAAQVFRLLSCIYAFG-FQLA
MSMEG_3239|M.smegmatis_MC2_155 -----------------MQREPDPVTPLWRAAQGFRLLSCLYALG-FHIA
TH_1288|M.thermoresistible__bu ----------------MAAERVDPATPLWRAAQVFRLLSCLYAVG-FQIA
MMAR_3958|M.marinum_M ----------------MATRGPDPTAPLWRAAQLFRLLSCGYALG-FHIA
MAV_4112|M.avium_104 ------------MLTTMANHGPDPTTPLWRAAQVFRLLSCLYATG-FQIA
MAB_4520c|M.abscessus_ATCC_199 -------MGSKNGTVPRWMSGSDPTASLWRAAQVFRLASFGYALLASQLA
Mb0868|M.bovis_AF2122/97 -RHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVG
Rv0845|M.tuberculosis_H37Rv -RHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVG
MUL_0350|M.ulcerans_Agy99 SCRLYGVPVVVTSDAELARVRRTHQLRAYRIGSVLRIGVVLFMVAAMLVG
:* .. :*: :.
Mflv_3580|M.gilvum_PYR-GCK VN-ADLESPVAGWVLFGALLAWSLACAVAYLQGFGRRLSWVLAEVAVVIA
Mvan_2835|M.vanbaalenii_PYR-1 VN-PDLEHPVGGWVLFAVLIGWSAACATAYLQGFGRRPAWVLAEIVVVVA
MSMEG_3239|M.smegmatis_MC2_155 IT-DDLRRPVLGWVLFAGLIVWSAACATVYLTGSRRRGTWVIAELVVVVA
TH_1288|M.thermoresistible__bu VN-GDLRHPAAGWLMLAVLLAWSAACAVGYLNGFARRPGWVIAEIVVVIA
MMAR_3958|M.marinum_M IN-ANLQRPLLGWALFAVLIGWSAACAVAYLRGFGRRPAWVITEIAVVVV
MAV_4112|M.avium_104 IN-PDLLRPVLGWVLFAGLIGWSAACALAYLRGFGRKPAWVLAELVVVVL
MAB_4520c|M.abscessus_ATCC_199 SY-TNYERQGLSWALYAVMAMWTGFAAVALSRNWFRRWQLVLCDQAIVIA
Mb0868|M.bovis_AF2122/97 TSRSEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPFA
Rv0845|M.tuberculosis_H37Rv TSRSEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPFA
MUL_0350|M.ulcerans_Agy99 TPRREWGAQTALICVYAFAALWALALAFRRSRPMVSLDRFANIARYEPLA
: : . *: * .
Mflv_3580|M.gilvum_PYR-GCK LVLSTEFLASDQWALDNQSWPTTLWATNATISAAILSG--PVAGMLAGLA
Mvan_2835|M.vanbaalenii_PYR-1 LMLSTEFVASDQWALDNQSWPTTLWATNATISAAILSG--PVSGMLAGLV
MSMEG_3239|M.smegmatis_MC2_155 LMLSTELVASEQWIADNQSWPTTLWATNATISVALHFG--PIGGMSAGLA
TH_1288|M.thermoresistible__bu LMLATGLIADAAWVADNQSLPTTLWATNATISAAIQFG--PVRGMLTGVA
MMAR_3958|M.marinum_M LMLSTKMVASAQWALDNQTWPTTLWASNATISAALQFG--PAGGMLTGIA
MAV_4112|M.avium_104 LMWSNHLVASPHWAADNQTWPTTLWASNPTISAAIQFG--PVGGMLTGLA
MAB_4520c|M.abscessus_ATCC_199 LMLAGRLVVDVQWYSGHQTLPTTLWVANAVVSMGLLRG--QLAGVISGFV
Mb0868|M.bovis_AF2122/97 FTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVVLACTL
Rv0845|M.tuberculosis_H37Rv FTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVVLACTL
MUL_0350|M.ulcerans_Agy99 FTAVDVLALTGFQLLSTDGIYSLLIMTLLPVLVALDISSRRAAVVLALTL
: : . : . * : .: . : :
Mflv_3580|M.gilvum_PYR-GCK VVAAGAALKGYVSIDLGRNATIVIELAVGLAVGMAAQTARRAHAELER--
Mvan_2835|M.vanbaalenii_PYR-1 VVAASAALKGYVSIDLGRNATVVIELAVGLAVGMAAQTARRAHAELER--
MSMEG_3239|M.smegmatis_MC2_155 VMATVALLKGHVSVNLGRNATIVIELAVGLAVGMAAQTARRAHAELER--
TH_1288|M.thermoresistible__bu VMLAAAALKGHISINLGRNATIVIELAVGLAVGMAAQTARRAHAELRR--
MMAR_3958|M.marinum_M VTAANEAVKGYVNVNLGRSATIVIELAVGLAVGMAARTARRAHADLQR--
MAV_4112|M.avium_104 VMTANFAVKNYFALNLGHNATVIIELAIGMAIGMAAQTARRAHDELQR--
MAB_4520c|M.abscessus_ATCC_199 LAAVSIAARGLPVSALWLDATMPALVVVGLAIGAASTTAKRTFHELRR--
Mb0868|M.bovis_AF2122/97 VGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEERHTRSV
Rv0845|M.tuberculosis_H37Rv VGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEERHTRSV
MUL_0350|M.ulcerans_Agy99 VGFGLALAQDPVVIRMNGWPEAIFRFGLYAFLCATALMVVRSEERHARSV
: . . . : : :: . * *
Mflv_3580|M.gilvum_PYR-GCK -----------ATRLAASLEERERLSRQVHDGAIQVLALVARRGREIGGD
Mvan_2835|M.vanbaalenii_PYR-1 -----------AARLSASLEERERLSRQVHDGAIQVLALVARRGREIGGD
MSMEG_3239|M.smegmatis_MC2_155 -----------AVRLSAALEERERLSRRVHDGAIQVLALVARRGREIGGE
TH_1288|M.thermoresistible__bu -----------AARLAAVTEERERLSRQVHDGAIQVLALVARRGREIGGE
MMAR_3958|M.marinum_M -----------AAQLSAALQERERLSRQVHDGVIQVLALVSRRGHEIGGP
MAV_4112|M.avium_104 -----------AARLTAAAQERDRLARQVHDGAIQVLALVAKKGHEIGGA
MAB_4520c|M.abscessus_ATCC_199 -----------AERAAAAAIERERLSRQVHDGVLQVLSYVKRRGTEIGGP
Mb0868|M.bovis_AF2122/97 AGLSALREELLAQTMTASEVLQRRIAEAIHDGPLQDVLAARQELIELDAV
Rv0845|M.tuberculosis_H37Rv AGLSALRAELLAQTMTASEVLQRRIAEAIHDGPLQDVLAARQELIELDAV
MUL_0350|M.ulcerans_Agy99 ATLSVIREELLAQTMTASEVLQRRISESIHDGPLQDVLAARQELIELRAA
* :* : *::. :*** :* : . :. *: .
Mflv_3580|M.gilvum_PYR-GCK T-------AQLAELAGEQERALRRLVSAADTPHR-AGATADLGAMLRSRA
Mvan_2835|M.vanbaalenii_PYR-1 T-------AQLAELAGEQERALRRLVSANDAEPR-KGAMSDIGAMLRRRA
MSMEG_3239|M.smegmatis_MC2_155 T-------AKLAELAGEQERALRRLVSAADTDTM-AGPLTDVGALLRTRA
TH_1288|M.thermoresistible__bu V-------TELAELAGEQERALRRLVSATESAPGGADHTVDVATLLRRRA
MMAR_3958|M.marinum_M T-------SELAELASEQERALRRWIISTDTDRDGNTRSVDLCALLRRRA
MAV_4112|M.avium_104 T-------TELADLASEQERALRRWLACTDIDRDADGDTVDLRTLLRRRE
MAB_4520c|M.abscessus_ATCC_199 T-------AELAAIAGEQEIALRELISGATQTTLADDELVDLRPLLRTQA
Mb0868|M.bovis_AF2122/97 TPGDERVGRALAGLQSASERLRQATFELHPAVLEQVGLGPAVKQLAASTA
Rv0845|M.tuberculosis_H37Rv TPGDERVGRALAGLQSASERLRQATFELHPAVLEQVGLGPAVKQLAASTA
MUL_0350|M.ulcerans_Agy99 APHDQRVSTALAGLQSASDLLRQATFELHPAVLEQVGLGAAVEQLASFHA
. ** : . .: : . : :
Mflv_3580|M.gilvum_PYR-GCK SDRVSVSVPAEPVLLDSAVATEFFAAVTNALDNAEAHAGPHARVYVLLED
Mvan_2835|M.vanbaalenii_PYR-1 TDRVSISVPADPVLLDATVADELLAAVTNALDNVEAHAGPVARAYVLLED
MSMEG_3239|M.smegmatis_MC2_155 SDRVSVSVPAEPVLLDHPVARELFAAAENALDNVAAHAGADARAFVLLED
TH_1288|M.thermoresistible__bu CDRVTMSLPGTPVPMDADVAAELDAAVGNALDNVALHAGPDARAFVLVED
MMAR_3958|M.marinum_M SDRVSMSLPGTPVTLTREVATELDAAVGNALDNVRLHAGPSARAFVLLED
MAV_4112|M.avium_104 SDRVSISLPGTPVRLGRWAATELDAAVGNALDNVVAHAGPGAHAFVLVED
MAB_4520c|M.abscessus_ATCC_199 STTVSVSAPGAPVLIGQHMASELAAVVRSALSNVALHAGPQAHAYVLIED
Mb0868|M.bovis_AF2122/97 QRSGIKISTDIDYPIRSGIDPIVFGVVRELLSNVVRHSG-ATTASVRLGI
Rv0845|M.tuberculosis_H37Rv QRSGIKISTDIDYPIRSGIDPIVFGVVRELLSNVVRHSG-ATTASVRLGI
MUL_0350|M.ulcerans_Agy99 QRSGIRITDDVDYPIRDEIDPIVFGVARELLSNVVQHSR-ARNASVALGI
: . ... . *.*. *: . * :
Mflv_3580|M.gilvum_PYR-GCK LGDSVTVSVRDDGVGIPEGRLEAAVGEGRVGVAKSIVGRMNWLGGRAELA
Mvan_2835|M.vanbaalenii_PYR-1 LGATVTVTVRDDGVGIPEGRLDEAVTEGRVGVSKSIVGRMDWLGGRAELS
MSMEG_3239|M.smegmatis_MC2_155 LGEEVTVSIRDDGVGIPEGRLAEAERQGRMGVAKSIVGRMDWLGGTAVLT
TH_1288|M.thermoresistible__bu LGDTVTVSIRDDGAGIAPGRLDEAVREGRMGIAKSIVGRMESLGGEAVLT
MMAR_3958|M.marinum_M LGDSVTVSVRDDGVGIAPGRLDEAAGQGHLGISKSIVGRLAALGGTAELS
MAV_4112|M.avium_104 LGDSVLVSVRDDGVGIAAGRVEEAARQGRLGISQSIVGRLASLGGTAELH
MAB_4520c|M.abscessus_ATCC_199 LVDSVVVTVRDDGSGIADGRLDQAEREGRMGVSRSILGRVADLGGAVLLE
Mb0868|M.bovis_AF2122/97 TDEKCVLDVADDGVGVTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLA
Rv0845|M.tuberculosis_H37Rv TDEKCVLDVADDGVGVTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLA
MUL_0350|M.ulcerans_Agy99 SDGVCVLDVADDGVGVSGETMARRLGQGHIGLASHRARVDAAGGSLVFLN
: : *** *:. : :*::*:: * . *
Mflv_3580|M.gilvum_PYR-GCK TGPGVGTEWELTVPR-------
Mvan_2835|M.vanbaalenii_PYR-1 TGPGMGTEWELTVSR-------
MSMEG_3239|M.smegmatis_MC2_155 TGPDSGTEWELTVPRTRKGQ--
TH_1288|M.thermoresistible__bu TS-ERGTEWELTVPRKDGRHG-
MMAR_3958|M.marinum_M TDQGEGTEWELRVPRREGSS--
MAV_4112|M.avium_104 SEPGAGTEWELCVPRREGRDDG
MAB_4520c|M.abscessus_ATCC_199 TGPGAGTEWEITVPKSQEVGA-
Mb0868|M.bovis_AF2122/97 TPRGTHVCVELPLKR-------
Rv0845|M.tuberculosis_H37Rv TPRGTHVCVELPLKR-------
MUL_0350|M.ulcerans_Agy99 TPTGTHVCVRIPLKG-------
: . .: :