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MARITSVPCDGETTTYVSPPKLRVARALARLPRLGDTVGLMLDPTFYLFEKYLRHGPVFTVKMPYQTYTV LAGSEAATFMSSKDGRECLTVGSSWRFVEEQFGGKDSLVAVDGPQHKQWRTLLQRGYSREAIADRYSEAI DVIDDAVDKHWRPGESVPVLPAMQKLSIAQVGTFLGGVRPTDDDIEDIALVTREILKIAPVQHIPKFMLQ LPRYVNARSRVARVAQNALALAGHSSASGRRGQSTLLEDILESCRDDPNAANQRNMLFHSVLPYFAGVET TSATATYALYLILRHPDVLCRIQDEVAVMFERGGITHDSLFHSTPVLHGAIMEAMRLRPIASFIIRVAAK DFEFHGHQIRSGEGVFIGTTVPHFLSEFYENPMKFDVDRYGDSAGPNRTPGAYSPFGRGPHMCVGKGLAE SLMQLMLARIIHRRTLELSSRSYRLSNRVSSSSPSPKFAVRVVSSRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3962 | - | - | 100% (467) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_3423 | - | 1e-20 | 23.08% (416) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_4693 | - | 9e-19 | 25.06% (395) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1694c | cyp139 | 1e-23 | 23.95% (430) | cytochrome P450 139 CYP139 |
| M. gilvum PYR-GCK | Mflv_4801 | - | 8e-22 | 27.14% (398) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1666c | cyp139 | 1e-23 | 23.95% (430) | cytochrome P450 139 CYP139 |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_2475 | cyp139A3 | 2e-25 | 24.53% (428) | cytochrome P450 139A3 Cyp139A3 |
| M. avium 104 | MAV_3106 | - | 7e-33 | 27.80% (428) | P450 heme-thiolate protein |
| M. smegmatis MC2 155 | MSMEG_0822 | - | 7e-20 | 27.38% (336) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3500 | - | 2e-19 | 24.45% (364) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3402 | cyp136A2 | 3e-25 | 25.17% (441) | cytochrome P450 136A2 Cyp136A2 |
| M. vanbaalenii PYR-1 | Mvan_5161 | - | 2e-19 | 28.57% (196) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1694c|M.bovis_AF2122/97 --------------------------------------------------
Rv1666c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2475|M.marinum_M --------------------------------------------------
MAV_3106|M.avium_104 --------------------------------------------------
MAB_3962|M.abscessus_ATCC_1997 ------------------------------MARITSVPCDGETTTYVSPP
MUL_3402|M.ulcerans_Agy99 MATISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPPP
Mvan_5161|M.vanbaalenii_PYR-1 ------------------------------------------MTAVKEVP
MSMEG_0822|M.smegmatis_MC2_155 -------------------------------------------MVETASP
Mflv_4801|M.gilvum_PYR-GCK -----------------------------------------MVDHRQPFP
TH_3500|M.thermoresistible__bu --------------------------------------------------
Mb1694c|M.bovis_AF2122/97 ---------------------MRYPLGEALLALYRWRGPLINAGVGG---
Rv1666c|M.tuberculosis_H37Rv ---------------------MRYPLGEALLALYRWRGPLINAGVGG---
MMAR_2475|M.marinum_M ---------------MSTYRTVPYRPGEALLALYRRRGAFIDAGVGR---
MAV_3106|M.avium_104 ---------------------MRYRPGEALLALYRRRGPVIDAGAGR---
MAB_3962|M.abscessus_ATCC_1997 KLRVARAL--ARLPRLGDTVGLMLDPTFYLFEKYLRHGPVFTVKMPY---
MUL_3402|M.ulcerans_Agy99 GSDLKPVVGDAGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPV---
Mvan_5161|M.vanbaalenii_PYR-1 RVS-------GGEEEHGHLEEFRTDPIGLMKRVREECGDVGWFQLAD---
MSMEG_0822|M.smegmatis_MC2_155 PLTELPLAPRNTLPCR-EQIRCLRSFIDGMQRLRDVGGPVTRIVLGPRWL
Mflv_4801|M.gilvum_PYR-GCK PLPHPPRRVPVVGDVFGFSADILTRPP-----SDPGLGPVFEFRFLG---
TH_3500|M.thermoresistible__bu --------MTSTAPDIDLTDGRFYADSASARAAYRWMRQNQPVFRDR---
Mb1694c|M.bovis_AF2122/97 --HGYTYLLGAEANRFVFAN--ADAFSWSQTFESLVPVDG-PTALIVSDG
Rv1666c|M.tuberculosis_H37Rv --HGYTYLLGAEANRFVFAN--ADAFSWSQTFESLVPVDG-PTALIVSDG
MMAR_2475|M.marinum_M --HGFVYLLGPEANRFVFAN--ADAFSWRETFESLVPVDG-PTALIVSDG
MAV_3106|M.avium_104 --RGYTLLLGAEANKFVFAN--ADAFSWRATFENLALVDG-PTALIVSDG
MAB_3962|M.abscessus_ATCC_1997 --QTYTVLAGSEAATFMSSKDGRECLTVGSSWRFVEEQFGGKDSLVAVDG
MUL_3402|M.ulcerans_Agy99 --LSAVVALGPDAAQVIYSNR-NKDYSQQGWVPVIGPFFR--RGLMLLDF
Mvan_5161|M.vanbaalenii_PYR-1 --KQVILLSGAEANEFFFRSS-DSELNQAEAYPFMTPIFG---EGVVFDA
MSMEG_0822|M.smegmatis_MC2_155 VPPALLVTSPQGAHDVLSLPDAVADRGGSRNMRQLQRLMG--GNLLDLPH
Mflv_4801|M.gilvum_PYR-GCK --ARYVVAASADAVAEVNDER-RFCKHVGPDIDALRIMGGDGLFTAYNEE
TH_3500|M.thermoresistible__bu ----NGLAAAATYQAIIESERNPELFSNTGGIRPEHPGMP---YMIDMDD
.
Mb1694c|M.bovis_AF2122/97 ADHRRRRSVVAPGLRHHHVQRYVATMVSNIDTVIDG-WQPGQR----LDI
Rv1666c|M.tuberculosis_H37Rv ADHRRRRSVVAPGLRHHHVQRYVATMVSNIDTVIDG-WQPGQR----LDI
MMAR_2475|M.marinum_M EDHRRRRSIVAPGLRHRSVQDYVATMVSTIDNVIDS-WRPGQP----LDI
MAV_3106|M.avium_104 DDHRRRRSVVAPGLRHRQIQDYVTTMVSCIDRVIDG-WRPGQR----LDV
MAB_3962|M.abscessus_ATCC_1997 PQHKQWRTLLQRGYSREAIADRYSEAIDVIDDAVDKHWRPGES----VPV
MUL_3402|M.ulcerans_Agy99 EEHMFHRRIMQQAFVRPRLVGYVEHMDEVASRAIAGEWATNDAR---FLL
Mvan_5161|M.vanbaalenii_PYR-1 DPERRAEMLHNTALRGEHMKGHATTIEAEVRKMIEG-WGESGE----IDL
MSMEG_0822|M.smegmatis_MC2_155 DRWLPRRRTLQPLFTKKHVPRFAGHMAAAAQSVAVS-WADGAT----VDL
Mflv_4801|M.gilvum_PYR-GCK PNWQRAHDLLMPAFSQQAMRGYHSAMLDAADGLVAR-WDGKARTGASVDV
TH_3500|M.thermoresistible__bu PEHLVRRKLVNHGFTRKRVRDREDSIARLCDTLIDNVCERGEC-----DF
. : .
Mb1694c|M.bovis_AF2122/97 YQELRSAVRRSTAESLFGQR----LAVHSDFLGEQLQPLLDLTRRP--PQ
Rv1666c|M.tuberculosis_H37Rv YQELRSAVRRSTAESLFGQR----LAVHSDFLGEQLQPLLDLTRRP--PQ
MMAR_2475|M.marinum_M YQEFRCAVRRSTTESLFGPR----LASHSDYLGRQLQPLIDLTHRL--PQ
MAV_3106|M.avium_104 YQHCRAAVRRSTAESLFGRR----LAVHSDALGEYLQPLLDLTHQP--PQ
MAB_3962|M.abscessus_ATCC_1997 LPAMQKLSIAQVGTFLGGVRPTDDDIEDIALVTREILKIAPVQHIP--KF
MUL_3402|M.ulcerans_Agy99 YPAMKKLTLDIASMVFMGHEP----GTDHELVTKVNRAFTTTTRAG--NA
Mvan_5161|M.vanbaalenii_PYR-1 LEFFAELTIYTSTACLIGLK------FRNQLDSRFANYYHLLERGT--DP
MSMEG_0822|M.smegmatis_MC2_155 DRACRALTLRALGRSVFGVDLD---QRAEDVGPALRTSLSWVADRA--SR
Mflv_4801|M.gilvum_PYR-GCK PADATRVTLETIGQCAAGHPFGCFDTEDPHPFVEHMVAGLKGSDWVGVLR
TH_3500|M.thermoresistible__bu VRDIAAPLPMAVIGDMLGVAP-----EDRGQLLKWSDDLVTG--------
*
Mb1694c|M.bovis_AF2122/97 VMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTAP---RPDDHMLTT
Rv1666c|M.tuberculosis_H37Rv VMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTAP---RPDDHMLTT
MMAR_2475|M.marinum_M VMQLQQRLNSPGWRRAMAARTRIDELIDAEIANARAEP---SPDDRMLTA
MAV_3106|M.avium_104 LVGLQRRINAPAWRRAMAARQRINNLVDTLIAEARAAP---NPDDHMLTM
MAB_3962|M.abscessus_ATCC_1997 MLQLPRYVN----ARSRVARVAQNALALAGHSSASGR----RGQSTLLED
MUL_3402|M.ulcerans_Agy99 VIRTS--VPPFTWWRGIRARQLLENYFAARVTERRGQ-----EGNDLLTV
Mvan_5161|M.vanbaalenii_PYR-1 LCYVDPYLPIESFRIRDEARAGLVELVQDVMHGRIANPPKDKSDRDMLDV
MSMEG_0822|M.smegmatis_MC2_155 PVNLPQWVPTRGQRKARAGNATLHRLAAEILADVRADP---DRDAPLVRA
Mflv_4801|M.gilvum_PYR-GCK ETVLPNFFARRAERRVRRHAVQMHRIADEIVSERLRDG--LGHHDDLLEL
TH_3500|M.thermoresistible__bu ---LSTTADEATVQAVMDAFAGYTAYTMEIIGKRRAEP-----TDDLFSI
:.
Mb1694c|M.bovis_AF2122/97 LISGCSEEGT-TLSDNEIRDSIVSLITAGYETTSGALAWAIYALLTVPGT
Rv1666c|M.tuberculosis_H37Rv LISGCSEEGT-TLSDNEIRDSIVSLITAGYETTSGALAWAIYALLTVPGT
MMAR_2475|M.marinum_M LINGRSEEGC-ALSDNEIRDSIVSLIAAGYETTSGALAWATYSLLTLPGA
MAV_3106|M.avium_104 LIDGRGDEGY-ALNDNEIRDAIVSLVTAGYETTSGALAWAVYLLLSQPGA
MAB_3962|M.abscessus_ATCC_1997 ILESCRDDPN-AANQRNMLFHSVLPYFAGVETTSATATYALYLILRHPDV
MUL_3402|M.ulcerans_Agy99 LCHTADEDGN-RFSDQDIVNHMIFLMMAAHDTSTSTATTMAYHLAAHPEW
Mvan_5161|M.vanbaalenii_PYR-1 LVSIKDEDGNPRFTANEITGMFISLMFAGHHTSSGTSSWTLIELLRHPEF
MSMEG_0822|M.smegmatis_MC2_155 LLEARDPETGRGLTDDQICDELVLFMLAGHDTTSTTLCYSLWALGHHPDI
Mflv_4801|M.gilvum_PYR-GCK MLTSDLDPAN-------IRYQLINFLVAGHETTSGALSFALYFLSRHPEV
TH_3500|M.thermoresistible__bu LINAEVEGQR--MSDEEIVFETLLILIGGDETTRHTLSGGVEQLLRHPDQ
: : : .. .*: : : *
Mb1694c|M.bovis_AF2122/97 WESAASEVARVLG-GRVPAADDLSALTYLNGVVHETLRLYSPGVISARRV
Rv1666c|M.tuberculosis_H37Rv WESAASEVARVLG-GRVPAADDLSALTYLNGVVHETLRLYSPGVISARRV
MMAR_2475|M.marinum_M WETAAREVARVLG-GTAPSAETLGALTYLNGVVHETLRLYSPGVVSARRL
MAV_3106|M.avium_104 WATAAGEVRRVLA-GRLPAAADLSGLTYLNGVVHETLRLYPPGVISARRV
MAB_3962|M.abscessus_ATCC_1997 LCRIQDEVAVMFERGGITHDSLFHSTPVLHGAIMEAMRLRPIASFIIRVA
MUL_3402|M.ulcerans_Agy99 QQRCRDESDRLGD--GPLDIEALEKLESLDLVMNESIRLVTPVQWAMRQT
Mvan_5161|M.vanbaalenii_PYR-1 YAKVQQELDDLYADGQEVSFHALRQIPSLDNALKETLRLHPPLIILMRVA
MSMEG_0822|M.smegmatis_MC2_155 QERVYAEVAALGD--RELTTDDVPQLTYTMRVLHEALRLCPPGSGTMRML
Mflv_4801|M.gilvum_PYR-GCK ADRARAEVAEVWGDDERPGFELIAKLRYVRRVLDEALRLQPTVPGYYREA
TH_3500|M.thermoresistible__bu WQRLRNDPDLVPG------------------AIEEMLRWTSPVKNMCRTL
: : .: * :* . *
Mb1694c|M.bovis_AF2122/97 LRDLWFDGHR-IRAGRLLIFSAYVTHRLPEIWPEPTEFRPLRWDPNAADY
Rv1666c|M.tuberculosis_H37Rv LRDLWFDGHR-IRAGRLLIFSAYVTHRLPEIWPEPTEFRPLRWDPNAADY
MMAR_2475|M.marinum_M IRDLWFDGHR-INSGRLLIFSAYVTHRIPEVWPNPTQFLPQRWDPAAPDY
MAV_3106|M.avium_104 MRDLRFEGRR-IRSGRLLIFSPYVTHRLPEIWPEPMRFAPERWNPDAPGY
MAB_3962|M.abscessus_ATCC_1997 AKDFEFHGHQ-IRSGEGVFIGTTVPHFLSEFYENPMKFDVDRYGDSAGPN
MUL_3402|M.ulcerans_Agy99 VRDTELLGYY-LPKGTNVIAYPGMNHRLPEFWTDPMTFDPDRFAEPRNEH
Mvan_5161|M.vanbaalenii_PYR-1 QDEFEVAGYP-IHKGQMVAASPAISNRIPEDFPNPDDFDPDRYEKPRQED
MSMEG_0822|M.smegmatis_MC2_155 NEEMTVDGYR-VEAGTVAIVNFYAMHRSPTLWDAPERFDPDRFSPERSAG
Mflv_4801|M.gilvum_PYR-GCK REDTVLAGVHPMRQGDWVLAMTMALHRDPRWGGDPDAFDPDRFAPDRVRA
TH_3500|M.thermoresistible__bu TADTEFHGTQ-LRKGEKMLLLFESANFDETVFENPDDFRIDRDPNP----
: . * : * : * * *
Mb1694c|M.bovis_AF2122/97 RKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVAR-AMLQLPAQRTH
Rv1666c|M.tuberculosis_H37Rv RKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVAR-AMLQLPAQRTH
MMAR_2475|M.marinum_M RKPAPHEFIPFSGGLHRCIGAVMATTELVVLLARLVAR-TRLRLPAQR--
MAV_3106|M.avium_104 RRPAPHEFIPFSAGLHRCVGAAMATTEMTVMLARLLAR-TRLRLPAQR--
MAB_3962|M.abscessus_ATCC_1997 RTPG--AYSPFGRGPHMCVGKGLAESLMQLMLARIIHR-RTLELSSRS--
MUL_3402|M.ulcerans_Agy99 KRHR-YAFTPFGGGAHKCLGMVFGQLEIKTILHRLLRR-YRLELARPDYR
Mvan_5161|M.vanbaalenii_PYR-1 LINR-WTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLRE-YEFEMAQPPES
MSMEG_0822|M.smegmatis_MC2_155 --RNRWQYLPFGGGPRSCIGDHFAMLEATLALATVIRA-VSVESQNTDLP
Mflv_4801|M.gilvum_PYR-GCK RPAG--LYKPFGTGPRSCIGRQFALHEAVLLLAVLLRR-YDL-VPEPGYQ
TH_3500|M.thermoresistible__bu -------HIAFGFGTHFCLGNQLARLELTLMLRRLLQRLPDLRLASDDPL
.*. * : *:* :. : :: .
Mb1694c|M.bovis_AF2122/97 RIRAAN-FAALRPWPGLTVEIRKSAPAQ
Rv1666c|M.tuberculosis_H37Rv RIRAAN-FAALRPWPGLTVEIRKSAPAQ
MMAR_2475|M.marinum_M -IRAAN-FAALAPKPGLRVEFVDSVPAQ
MAV_3106|M.avium_104 -LRAAN-VAALRPTPGLTVEVIDSVPAQ
MAB_3962|M.abscessus_ATCC_1997 -YRLSNRVSSSSPSPKFAVRVVSSRR--
MUL_3402|M.ulcerans_Agy99 ACWDYG--GMPVPKDGMPIVLRPL----
Mvan_5161|M.vanbaalenii_PYR-1 YQNDHSKMVVQLARPAKVRYRRRVRD--
MSMEG_0822|M.smegmatis_MC2_155 VETPFT-VIAAAPVPARVTRR-------
Mflv_4801|M.gilvum_PYR-GCK LQVAQR--LTLMPKDFRLTLRRRRSE--
TH_3500|M.thermoresistible__bu PLRPANFVSGPEAMPVVFTPTEPVSA--
.