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VSKTAKIALPPGPPLPLAVQSILMASYGLRFLAGCQRRYGNMFTLRIPLSGKVVYLADPADIKTVYAGDP HVFHSGEAHWFFRGLLGDSSLFVLDEDEHHHQRRLLMPAFHRDAVARQATQMAQIAAANIAEWPVGESFP VAPRTTDITLEVILRTVIGASDPVRLAALRKVVPRLLYMKPWETPAITNPGLRRYWPWTAVGRRMAETDA LLYAEIAERRADPNLTERTDVLAMLVRATDDDGRTMSDQELRDHLLTSIAAGHETTATALSWVLERLTRH PDALLKAAQAAEASAAGDPAGDEYLDAVVKETLRIRPVIFSSGRVLKESVEVGGYQLPVGIMVDPAIGLV HASGAVYPDPARFDPDRMVGTTLSPTTWLPFGGGNRRCLGATFAMVEIRVVLREILRRVELNTTTAPDEK QQAKHVTFVPHRGGSISVRAIRTCAPAVTPTCPADVHGTGQARDPQR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4693 | - | - | 100% (467) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_1427c | - | 2e-76 | 37.56% (450) | putative cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_4944c | - | 9e-30 | 25.27% (459) | putative cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0583 | cyp135B1 | 1e-176 | 67.17% (460) | cytochrome P450 135B1 |
| M. gilvum PYR-GCK | Mflv_1104 | - | 9e-76 | 38.32% (441) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0568 | cyp135B1 | 1e-176 | 67.17% (460) | cytochrome P450 135B1 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-11 | 28.42% (183) | putative cytochrome p450 |
| M. marinum M | MMAR_0938 | cyp135B4 | 1e-164 | 64.13% (460) | cytochrome P450 135B4 Cyp135B4 |
| M. avium 104 | MAV_5160 | - | 2e-81 | 39.68% (441) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_1213 | - | 1e-156 | 63.16% (437) | cytochrome P450 monooxygenase |
| M. thermoresistible (build 8) | TH_2672 | - | 1e-156 | 64.34% (429) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3402 | cyp136A2 | 1e-27 | 27.76% (335) | cytochrome P450 136A2 Cyp136A2 |
| M. vanbaalenii PYR-1 | Mvan_1038 | - | 1e-154 | 63.68% (446) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1104|M.gilvum_PYR-GCK ---------------------------------------------MRLPP
MAV_5160|M.avium_104 ----------------------------------MSEVATAPLAAVHLPP
MSMEG_1213|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1038|M.vanbaalenii_PYR-1 --------------------------MRDPRYGRGRAFYAGVMTPTSLPP
TH_2672|M.thermoresistible__bu --------------------------------------------------
Mb0583|M.bovis_AF2122/97 ---------------------------------------MSGTSSMGLPP
Rv0568|M.tuberculosis_H37Rv ---------------------------------------MSGTSSMGLPP
MMAR_0938|M.marinum_M -----------------------------------------MTKTATLPP
MAB_4693|M.abscessus_ATCC_1997 ---------------------------------------MSKTAKIALPP
MUL_3402|M.ulcerans_Agy99 MATISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPPP
MLBr_02088|M.leprae_Br4923 --------------------------MRTCVPTRTCVYAFIEYLSHNRPM
Mflv_1104|M.gilvum_PYR-GCK T---------PRIPRFLQGLGFSL--------SRQWTVAQVVRRYGDVFT
MAV_5160|M.avium_104 A---------VRGPKLLQGIGFAV--------SRRTMMRRLSRRYGNVFT
MSMEG_1213|M.smegmatis_MC2_155 ----------------MQTAMMLR--------HWSRFVSACRRRYGDVFT
Mvan_1038|M.vanbaalenii_PYR-1 G---------PRLPRSVQAALMLR--------CGPRFVAACRRRYGSAFT
TH_2672|M.thermoresistible__bu ----------------VQAWLMLR--------HGKWFIAACQRRYGPVFT
Mb0583|M.bovis_AF2122/97 G---------PRLSGSVQAVLMLR--------HGLRFLTACQRRYGSVFT
Rv0568|M.tuberculosis_H37Rv G---------PRLSGSVQAVLMLR--------HGLRFLTACQRRYGSVFT
MMAR_0938|M.marinum_M G---------PRLPRAVQAALMLR--------HAPRFLTACKRRYGSVFT
MAB_4693|M.abscessus_ATCC_1997 G---------PPLPLAVQSILMAS--------YGLRFLAGCQRRYGNMFT
MUL_3402|M.ulcerans_Agy99 GSDLKPVVGDAGLPILGHLIEMLR--------GGPDYLMFLYRTKGPVVF
MLBr_02088|M.leprae_Br4923 G---------TNPPSLVEAQMLLLRLIDPGTRADPFPVYRALIDYGPMQL
. : : *
Mflv_1104|M.gilvum_PYR-GCK MTLPVFGKTVLVTDPALAKQLFMANTD--DVGNIQPNLS----RVLGSGS
MAV_5160|M.avium_104 LRLPMWGPVVMVSDPQLAKQIFTTSPD--ELGNIQPNLS----RLFGSGS
MSMEG_1213|M.smegmatis_MC2_155 LRIASMGTWVYLADPADIKTVFAGDPTVFHAGEANSMLS----GLLGETS
Mvan_1038|M.vanbaalenii_PYR-1 LRVASMGTLVYLTDPADIKTVFAGDPDIYHAGEANSMLK----GLLGDTS
TH_2672|M.thermoresistible__bu LRITSMGTLVYLTDPADIKAVFTGDPDTFHAGEANSMLS----GILGETS
Mb0583|M.bovis_AF2122/97 LHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEANSMLA----GLLGDSS
Rv0568|M.tuberculosis_H37Rv LHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEANSMLA----GLLGDSS
MMAR_0938|M.marinum_M LRVAGLGTMVNVTDPVVIKKVFAGDPRVFHAGEANTMLA----GLLGESS
MAB_4693|M.abscessus_ATCC_1997 LRIPLSGKVVYLADPADIKTVYAGDPHVFHSGEAHWFFR----GLLGDSS
MUL_3402|M.ulcerans_Agy99 GDSPVLSAVVALG-PDAAQVIYSNRNKDYSQQGWVPVIG----PFFRRG-
MLBr_02088|M.leprae_Br4923 PGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQAIAAGAEPRPFYASS
. : :
Mflv_1104|M.gilvum_PYR-GCK VFALDGTDHRLRRKLLTPPFHGKSIKNYERIFEEETLREAAS-WPEGQP-
MAV_5160|M.avium_104 VFGLEGDDHRRRRRLLAPPFHGKSMKNYESIIEEETLRETAG-WPEGES-
MSMEG_1213|M.smegmatis_MC2_155 VLVIDEDVHRDRRRLMLAPFARDAVARQTGVMAEVAATNIAS-WPVGTP-
Mvan_1038|M.vanbaalenii_PYR-1 VLVIDGDLHRDRRRLMLAPFARDAVAAQAGVIAEIAADNIAG-WPVGET-
TH_2672|M.thermoresistible__bu VLVIDGDLHRRRRRLMLPSFHRDAVTRQADAMAEIAAADIAG-WPVGTT-
Mb0583|M.bovis_AF2122/97 LLLIDDDVHRDRRRLMSPPFHRDAVARQAGPIAEIAAANIAG-WPMAKA-
Rv0568|M.tuberculosis_H37Rv LLLIDDDVHRDRRRLMSPPFHRDAVARQAGPIAEIAAANIAG-WPMAKA-
MMAR_0938|M.marinum_M LLVVDDDVHRDRRRMMLPPFQREAVAHQAQLMSEIAAENIAG-WPVGRT-
MAB_4693|M.abscessus_ATCC_1997 LFVLDEDEHHHQRRLLMPAFHRDAVARQATQMAQIAAANIAE-WPVGES-
MUL_3402|M.ulcerans_Agy99 LMLLDFEEHMFHRRIMQQAFVRPRLVGYVEHMDEVASRAIAGEWATNDAR
MLBr_02088|M.leprae_Br4923 FMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAALVDSLLDK--GAAAGQ
.: :: * *::: .* : : .
Mflv_1104|M.gilvum_PYR-GCK FETLEPMMRITLNAILRAVFGADG-AHLDELRRIIPPWVTLGSRLAVLPT
MAV_5160|M.avium_104 FPTLPPMMRITLNAILRAVFGAEG-AELDELRRLIPPWVTLGSRLAALPK
MSMEG_1213|M.smegmatis_MC2_155 FPVAPKMAEIALEVILRTVIGATEPARLAALRHVMPQLLGIGP-WQSLAI
Mvan_1038|M.vanbaalenii_PYR-1 FPVAPKMSEITLEVILRTVIGASDQARLAALRTVMPRVLSVGP-WETLAI
TH_2672|M.thermoresistible__bu FAAAPRMSQITLEVILRVVIGAGDPGRLAALRTVLPRLIDIGP-WLSLAV
Mb0583|M.bovis_AF2122/97 FAVAPKMSEITLEVILRTVIGASDPVRLAALRKVMPRLLNVGP-WATLAL
Rv0568|M.tuberculosis_H37Rv FAVAPKMSEITLEVILRTVIGASDPVRLAALRKVMPRLLNVGP-WATLAL
MMAR_0938|M.marinum_M FAVAPKMAEITLEVILRTVIGATDPDRLAALRKVMPRLLNVGP-WETLAL
MAB_4693|M.abscessus_ATCC_1997 FPVAPRTTDITLEVILRTVIGASDPVRLAALRKVVPRLLYMKP-WETPAI
MUL_3402|M.ulcerans_Agy99 FLLYPAMKKLTLDIASMVFMGHEPGTDHELVTKVNRAFTTTTR--AGNAV
MLBr_02088|M.leprae_Br4923 FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSALLVQSVDP-FITITG
* .:* .
Mflv_1104|M.gilvum_PYR-GCK PHRTYGRFSPWGRLARYRRRYDEVIGRLIDAVQADPNFESRDDVLALLLR
MAV_5160|M.avium_104 PQR-YPRFGPWGQLDRWRRQYDGVIERLIAAEQADPNFAERTDVLALLLR
MSMEG_1213|M.smegmatis_MC2_155 ASPGLQRRRPWRTLQRNLAEADRLLYAEIAACRAGPDLASRPDALAMLVR
Mvan_1038|M.vanbaalenii_PYR-1 ANQDLLRRRPWRAVRDAIAEADRLLYAEIADRRADPDLDTRTDALAMLVR
TH_2672|M.thermoresistible__bu ASPHLQRHRPWQRLQRNLADADRLLYAEIAERRADPELDTRTDTLAMLVR
Mb0583|M.bovis_AF2122/97 ANPSLLNNRLWSRLRRRIEEADALLYAEIADRRADPDLAARTDTLAMLVR
Rv0568|M.tuberculosis_H37Rv ANPSLLNNRLWSRLRRRIEEADALLYAEIADRRADPDLAARTDTLAMLVR
MMAR_0938|M.marinum_M AKPDLLSRRAWRRLRRAIDEANELLYAEIAERRADPNLAERTDVLATLVR
MAB_4693|M.abscessus_ATCC_1997 TNPGLRRYWPWTAVGRRMAETDALLYAEIAERRADPNLTERTDVLAMLVR
MUL_3402|M.ulcerans_Agy99 IRTSVPPFTWWRGIR-----ARQLLENYFAARVTERRGQEGNDLLTVLCH
MLBr_02088|M.leprae_Br4923 EPPEATEERLR---------AGVWLRDYLEQLVKCRRGTPGEDLISRLIE
: : * :: * .
Mflv_1104|M.gilvum_PYR-GCK STYEDGS----SMSRQDIGDELLTLLAAGHETTAATLGWVFERISRHPDV
MAV_5160|M.avium_104 STYDDGA----AMSHKEIGDELLTLLAAGHETTASTLAWAFERISRHPEL
MSMEG_1213|M.smegmatis_MC2_155 AANDEGR----TMTDRELRDQLMTLLVAGHETTATGLSWTLERLIRHPAV
Mvan_1038|M.vanbaalenii_PYR-1 AG---------DMSDKELRDQLITLLVAGHDTTATALSWALERLTRHPAV
TH_2672|M.thermoresistible__bu SADDDGQ----AMSDRELRDQLMTLLLAGHDTTATALSWALERLTRHPML
Mb0583|M.bovis_AF2122/97 AADEDGR----TMTERELRDQLITLLVAGHDTTATGLSWALERLTRHPVT
Rv0568|M.tuberculosis_H37Rv AADEDGR----TMTERELRDQLITLLVAGHDTTATGLSWALERLTRHPVT
MMAR_0938|M.marinum_M AVDGDTAKPSGRMTDEELRDQLMTLLVAGHDTTATGLAWALERLTRHPAI
MAB_4693|M.abscessus_ATCC_1997 ATDDDGR----TMSDQELRDHLLTSIAAGHETTATALSWVLERLTRHPDA
MUL_3402|M.ulcerans_Agy99 TADEDGN----RFSDQDIVNHMIFLMMAAHDTSTSTATTMAYHLAAHPEW
MLBr_02088|M.leprae_Br4923 LDESGDQ-----LTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRNPSQ
:: .:: : *.*:*:. : :*
Mflv_1104|M.gilvum_PYR-GCK LARLQAEAD-----------TDGNEYRQAVILETQRVRTVIDFAGRHVYA
MAV_5160|M.avium_104 LARLVEEAD-----------NGGNELRQAAILEVQRARTVIDFAGRHVYP
MSMEG_1213|M.smegmatis_MC2_155 LDKAVAAAR---TT-----DGSGEAYLDAVVRESLRIRPVVFEAGR-VLT
Mvan_1038|M.vanbaalenii_PYR-1 LAKAVRAAR---DG-----D---DDYLDAVAKETLRDRPVVFDVGR-VLK
TH_2672|M.thermoresistible__bu LAEAEQAAEASAAG-----DPAGDEYLDAVCRETLRNRTVVFDVGR-VLK
Mb0583|M.bovis_AF2122/97 LAKAVQAADASAAG-----DPAGDEYLDAVAKETLRIRPVVYDVGR-VLT
Rv0568|M.tuberculosis_H37Rv LAKAVQAADASAAG-----DPAGDEYLDAVAKETLRIRPVVYDVGR-VLT
MMAR_0938|M.marinum_M LAKAVRAAEASAAG-----DPSGDEYLDALAKETLRIRPVVFDVGR-ILT
MAB_4693|M.abscessus_ATCC_1997 LLKAAQAAEASAAG-----DPAGDEYLDAVVKETLRIRPVIFSSGR-VLK
MUL_3402|M.ulcerans_Agy99 QQRCRDESDRLGDGPLDIEALEKLESLDLVMNESIRLVTPVQWAMR-QTV
MLBr_02088|M.leprae_Br4923 WKALSSNPQ----------------RAPLVVEETLRYDPAIHLIGR-VAA
. * * . : *
Mflv_1104|M.gilvum_PYR-GCK PTFELGEWIIPQGYSIVVAIGQVHHREQDYLDPEDFDPQRFVGQR-----
MAV_5160|M.avium_104 DVYRLGEWVIPRGYSIIVGIAQIHDNPDVFPDPRRFDPQRFIDNK-----
MSMEG_1213|M.smegmatis_MC2_155 EPVELGGYLLPAGTLVAPSIGLVHASADVYPDPDRFEPDRMLAST-----
Mvan_1038|M.vanbaalenii_PYR-1 APVELAGYRLPAGVMVIPGLVAVHADSQIYPHADRFDPDRMLGAT-----
TH_2672|M.thermoresistible__bu RPVELAGHRLPAGVMVVPGMVRVHADGELYPDPERFDPHRMLGETPGQPA
Mb0583|M.bovis_AF2122/97 EAVEVAGYRLPAGVMVVPAIGLVHASAQLYPDPERFDPDRMVGAT-----
Rv0568|M.tuberculosis_H37Rv EAVEVAGYRLPAGVMVVPAIGLVHASAQLYPDPERFDPDRMVGAT-----
MMAR_0938|M.marinum_M EPTELAGYQLPAGTMVVASIGLVHANAEVYPDPDRFDPDRMIDAT-----
MAB_4693|M.abscessus_ATCC_1997 ESVEVGGYQLPVGIMVDPAIGLVHASGAVYPDPARFDPDRMVGTT-----
MUL_3402|M.ulcerans_Agy99 RDTELLGYYLPKGTNVIAYPGMNHRLPEFWTDPMTFDPDRFAEPR-NEHK
MLBr_02088|M.leprae_Br4923 KDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRH-----
: :. * : : : . *:*.*
Mflv_1104|M.gilvum_PYR-GCK PSTLSHIPFGGGTRRCVGAVFANVEMDIVLRTVFRHFTIETTTAPGEKMH
MAV_5160|M.avium_104 PSALSWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTIETTDAPDEPWH
MSMEG_1213|M.smegmatis_MC2_155 QAPSTWLPFGGGNRRCLGATFALVEMRVVLREILHRVDLFATTARGEKQR
Mvan_1038|M.vanbaalenii_PYR-1 LSPSSYLPFGGGNRRCLGATFAMVEFKVVLREILRRVELETTTARGEHRR
TH_2672|M.thermoresistible__bu LTPTTWFPFGGGNRRCLGATFAMVEMRVVLREILRRVELETTSARGERPR
Mb0583|M.bovis_AF2122/97 LSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRVELSTTTTSGERPK
Rv0568|M.tuberculosis_H37Rv LSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRVELSTTTTSGERPK
MMAR_0938|M.marinum_M LTPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRVDLATTTAPDERYK
MAB_4693|M.abscessus_ATCC_1997 LSPTTWLPFGGGNRRCLGATFAMVEIRVVLREILRRVELNTTTAPDEKQQ
MUL_3402|M.ulcerans_Agy99 RHRYAFTPFGGGAHKCLGMVFGQLEIKTILHRLLRRYRLELARPDYRACW
MLBr_02088|M.leprae_Br4923 ------LAFAVGSHFCLGAALARLEATVTLSAISARFPQVQLAG--ELVY
.*. * : *:* .:. :* * : : .
Mflv_1104|M.gilvum_PYR-GCK SRGVAYTPDDGGRVVMRRR-------------------------------
MAV_5160|M.avium_104 CRGVAFTPKHGGRIVVHRR-------------------------------
MSMEG_1213|M.smegmatis_MC2_155 LKHVTMIPHRGGRICVRALR--------DVAPAPMTCPAEARRA------
Mvan_1038|M.vanbaalenii_PYR-1 LKHVIFVPHRGARIRVRAKR--------VVAAEAPKCPMSGPA-------
TH_2672|M.thermoresistible__bu LKHVVFVPRRGARIRVRAHRKPVADNTVDDAAGPVPSPVPPRR-------
Mb0583|M.bovis_AF2122/97 LKHVIMVPHRGARIRVRATRDVSATS--QATAQGAGCPAARGGGPSRAVG
Rv0568|M.tuberculosis_H37Rv LKHVIMVPHRGARIRVRATRDVSATS--QATAQGAGCPAARGGGPSRAVG
MMAR_0938|M.marinum_M LKHVILVPHRDARIRVRA---ITAVS--PAVPEAPGCPVAHAKS------
MAB_4693|M.abscessus_ATCC_1997 AKHVTFVPHRGGSISVRAIR-------TCAPAVTPTCPADVHGTGQARDP
MUL_3402|M.ulcerans_Agy99 DYGGMPVPKDGMPIVLRPL-------------------------------
MLBr_02088|M.leprae_Br4923 KPNVAMRGMSALPVQV----------------------------------
: :
Mflv_1104|M.gilvum_PYR-GCK --
MAV_5160|M.avium_104 --
MSMEG_1213|M.smegmatis_MC2_155 --
Mvan_1038|M.vanbaalenii_PYR-1 --
TH_2672|M.thermoresistible__bu --
Mb0583|M.bovis_AF2122/97 SQ
Rv0568|M.tuberculosis_H37Rv SQ
MMAR_0938|M.marinum_M --
MAB_4693|M.abscessus_ATCC_1997 QR
MUL_3402|M.ulcerans_Agy99 --
MLBr_02088|M.leprae_Br4923 --