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VATISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPPPGSDLKPVVGDAGLPILGHLI EMLRGGPDYLMFLYRTKGPVVFGDSPVLSAVVALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFRRGLMLL DFEEHMFHRRIMQQAFVRPRLVGYVEHMDEVASRAIAGEWATNDARFLLYPAMKKLTLDIASMVFMGHEP GTDHELVTKVNRAFTTTTRAGNAVIRTSVPPFTWWRGIRARQLLENYFAARVTERRGQEGNDLLTVLCHT ADEDGNRFSDQDIVNHMIFLMMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEALEKLE SLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNHRLPEFWTDPMTFDPDRFAEPRN EHKRHRYAFTPFGGGAHKCLGMVFGQLEIKTILHRLLRRYRLELARPDYRACWDYGGMPVPKDGMPIVLR PL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3402 | cyp136A2 | - | 100% (492) | cytochrome P450 136A2 Cyp136A2 |
| M. ulcerans Agy99 | MUL_0473 | cyp51B1 | 1e-30 | 37.19% (199) | cytochrome P450 51B1 Cyp51B1 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 4e-30 | 27.34% (384) | cytochrome P450 185A4 Cyp185A4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3085 | cyp136 | 0.0 | 86.15% (491) | cytochrome P450 136 |
| M. gilvum PYR-GCK | Mflv_4315 | - | 0.0 | 67.89% (492) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3059 | cyp136 | 0.0 | 85.95% (491) | cytochrome P450 136 |
| M. leprae Br4923 | MLBr_02088 | - | 6e-14 | 23.19% (332) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3423 | - | 0.0 | 66.33% (493) | cytochrome P450 |
| M. marinum M | MMAR_1634 | cyp136A2 | 0.0 | 99.39% (492) | cytochrome P450 136A2 Cyp136A2 |
| M. avium 104 | MAV_3927 | - | 0.0 | 73.73% (491) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_2289 | - | 0.0 | 67.76% (490) | cytochrome p450 |
| M. thermoresistible (build 8) | TH_2954 | - | 0.0 | 73.58% (492) | PUTATIVE cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_2031 | - | 0.0 | 67.96% (490) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3402|M.ulcerans_Agy99 MA-TISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPP
MMAR_1634|M.marinum_M MA-TISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPP
Mb3085|M.bovis_AF2122/97 MA-TIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKKLAEPP
Rv3059|M.tuberculosis_H37Rv MA-TIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKKLAEPP
MSMEG_2289|M.smegmatis_MC2_155 MPTTISTPRYLLDQARRRFTPTPNTIPGMGAIEKRLKRKQWDQFVFSTPP
Mvan_2031|M.vanbaalenii_PYR-1 MP-SISTTDYVLDQAKRRLKPTPVTIPGMGAVEKRLKDKHWDQFVLAEPP
Mflv_4315|M.gilvum_PYR-GCK MT-AISTPEYLLDQAKRRLKPTPVTIPGMGAIEKRLLEKQWDEIILAEPP
TH_2954|M.thermoresistible__bu MA-TINTRDYLLDQAKRRLIPTVNNIPGMGIVEKKLREREWKQFKLADPP
MAV_3927|M.avium_104 MTATISTPQYLLDQARRRFTPTLNTIPGMGAIEKRLLAHEWQTKVLAEPP
MAB_3423|M.abscessus_ATCC_1997 MA-TISSTDYLIDQAKRRL-PTMNTLPGMGYIENYLNNREWPMTELAAPP
MLBr_02088|M.leprae_Br4923 -----MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPG
. : *. * . : *
MUL_3402|M.ulcerans_Agy99 PGSDLKPVVGDAGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPVLS
MMAR_1634|M.marinum_M PGSDLKPVVGDAGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPVLP
Mb3085|M.bovis_AF2122/97 PGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLP
Rv3059|M.tuberculosis_H37Rv PGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLP
MSMEG_2289|M.smegmatis_MC2_155 AGSGLKPIMGDSGLPVLGHMIEIFRGGPDFILEQYRRNGPIHYAYSPALS
Mvan_2031|M.vanbaalenii_PYR-1 AGSDLKPILGDAGLPIIGHMIEIFRGGPDFILEIYRKHGPVYFAESPALS
Mflv_4315|M.gilvum_PYR-GCK AGSGLKAVRGDNGLPIVAHMIEMFRGGPDFILHQYRKYGPVYYSGSQVLP
TH_2954|M.thermoresistible__bu PGSGLKPVMGDAGLPILGHMIEAFRGGPDYVLEVYRKYGPVHYAYSPALA
MAV_3927|M.avium_104 AGSGLKPVLGDAGLPILGHIIELFRGGPDYALFLYRNHGPLIYLDSPIMP
MAB_3423|M.abscessus_ATCC_1997 PGSGLKPVMGDQGLPMLGHMVEMFRGGIDWVLNMYQERGPVSWTQTPIGK
MLBr_02088|M.leprae_Br4923 TRADPFPVYR----ALIDYGPMQLPGMP---LTVFSSFSDCDEALRHPLS
. :. .: .:: : : * : : .
MUL_3402|M.ulcerans_Agy99 AVVALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFRRGLMLLDFEEHMFHR
MMAR_1634|M.marinum_M AVVALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFRRGLMLLDFEEHMFHR
Mb3085|M.bovis_AF2122/97 GVAALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHR
Rv3059|M.tuberculosis_H37Rv GVAALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHR
MSMEG_2289|M.smegmatis_MC2_155 SVMALGPDATQTVFSNRNKDYSQRAWDPVIGPFFEGGLMLLDFDEHMYHR
Mvan_2031|M.vanbaalenii_PYR-1 SVMALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLLDFDEHMFHR
Mflv_4315|M.gilvum_PYR-GCK AVGALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLRDFEDHMYHR
TH_2954|M.thermoresistible__bu SVSALGPDATQEIFSNKNKDYSQKGWHPVIGPFFNRGLMMLDFEEHMYHR
MAV_3927|M.avium_104 AVTALGPDATQAVFSNRNKDYSQKGWHPVIGPFFNRGLMMLDFDEHMYHR
MAB_3423|M.abscessus_ATCC_1997 IVAALGPDATQAVFSNANKDFSQQGWVPVIGPFFNRGLMLLDFQEHREHR
MLBr_02088|M.leprae_Br4923 ASDRLKATLAQQAIAAGAEPR----------PFYASSFMFLDPPDHTRLR
* . :* : : **: .:*: * :* *
MUL_3402|M.ulcerans_Agy99 RIMQQAFVRPRLVGYVEHMDEVASRAIAGEWATNDARFLLYPAMKKLTLD
MMAR_1634|M.marinum_M RIMQEAFVRSRLVGYVEHMDEVASRAIAGEWATNDARFLLYPAMKKLTLD
Mb3085|M.bovis_AF2122/97 RIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLD
Rv3059|M.tuberculosis_H37Rv RIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLD
MSMEG_2289|M.smegmatis_MC2_155 RIMQDAFTRSRLTGYIPHIDSVASQVLANDWVSDDPRFLFYPAIKELTLD
Mvan_2031|M.vanbaalenii_PYR-1 RIMQEAFTRSRLTGYVSHIDSVASAVLANDWVANDPRFLFHPAIKELTLD
Mflv_4315|M.gilvum_PYR-GCK RIMQEAFTRSRLTGYVEHIDQVASAVIANDWVADDRRFLFYPAVKELTLD
TH_2954|M.thermoresistible__bu RIMQEAFTRPRLAGYVEHIDRVASEVVVRDWATDDPRFLFHPSVKKLTLD
MAV_3927|M.avium_104 RIMQEAFTRSRLTGYVEHIDRVATDIVA-DWPTNDARFLFHPAMKELTLD
MAB_3423|M.abscessus_ATCC_1997 LIMQQAFLRSRLAGYVEQIDAVASEIVA-QWPTNDNRFLFYPAIKELTLD
MLBr_02088|M.leprae_Br4923 KLVSKAFAPKVVQALEGDIAALVDSLLDKGAAAG-----QFDVIADLAFP
::..** : . .: :. : . . : *::
MUL_3402|M.ulcerans_Agy99 IASMVFMGHEPGTDHELVTKVNRAFTTTTRAGNAVIRTSVPPFTWWRGIR
MMAR_1634|M.marinum_M IASMVFMGHEPGTDHELVTKVNRAFTTTTRAGNAVIRTSVPPFTWWRGIR
Mb3085|M.bovis_AF2122/97 IASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRGLR
Rv3059|M.tuberculosis_H37Rv IASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRGLR
MSMEG_2289|M.smegmatis_MC2_155 IASEVFMGVPAGTDKKLVTTVNHAFTTTTRAGNAIVRTPVPPLKWWRGIQ
Mvan_2031|M.vanbaalenii_PYR-1 IASEVFMGVPAGTDRALVTTVNQAFTTTTRAGNAIVRKPVPPLTWWRGIK
Mflv_4315|M.gilvum_PYR-GCK IASVVFMGHKAGTDKQLVTTVNEAFTTTTRAGNAIVRKPVPPLSWWRGIR
TH_2954|M.thermoresistible__bu IASVVFMGHEPGSDKELVTKVNDAFTITTRAGGAIIRTSVPPFKWWRGLQ
MAV_3927|M.avium_104 IASLVFMGHEPGTDHDLVTKVNQAFTTTTRAGGAIIRQPIPPFKWWRGLR
MAB_3423|M.abscessus_ATCC_1997 VASVVFMGNEPHAQHERLEKVNKAFVATTRAGGAIFRFGLPPFKWWQGLQ
MLBr_02088|M.leprae_Br4923 LAVAVICRLLGVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLR
:* *: . . . : . .. : ** . ::
MUL_3402|M.ulcerans_Agy99 ARQLLENYFAARVT-ERRGQEGNDLLTVLCHTADEDGNRFSDQDIVNHMI
MMAR_1634|M.marinum_M ARQLLENYFAARVT-ERRGQEGNDLLTVLCHTADEDGNRFSDQDIVNHMI
Mb3085|M.bovis_AF2122/97 ARELLENYFTARVK-ERREASGNDLLTVLCQTEDDDGNRFSDADIVNHMI
Rv3059|M.tuberculosis_H37Rv ARELLENYFTARVK-ERREASGNDLLTVLCQTEDDDGNRFSDADIVNHMI
MSMEG_2289|M.smegmatis_MC2_155 ARKTLEDYFLSRID-EKRRAESTDMFSVLCHSADEDGQTFTDDQIVSHMI
Mvan_2031|M.vanbaalenii_PYR-1 ARKTLEDYFSSRIG-EKRRSESTDMFSVLCHSADEDGQSFTDDQIVSHMI
Mflv_4315|M.gilvum_PYR-GCK ARKTLEDYFNAGIA-EKRRSESTDMFSVLCHAQDEDGQSFTDQDVVSHMI
TH_2954|M.thermoresistible__bu ARKVLEDYFVQRVK-ERRDSGGTDMLSVLCHATDEDGNTFTDEDIVNHMI
MAV_3927|M.avium_104 ARQLLEDYFSERVK-ERRNATGNDMLTVLCHTEDDDGNSFTDDDIVNHMI
MAB_3423|M.abscessus_ATCC_1997 GRKLLEEYFAERVGIARQKTEGADMLTALCHAETDEGDAFTDTDIVNHMI
MLBr_02088|M.leprae_Br4923 AGVWLRDYLEQLVK-CRRGTPGEDLISRLIELD-ESGDQLTEEEIIATCG
. *.:*: : :: . *::: * . :.*: ::: :::
MUL_3402|M.ulcerans_Agy99 FLMMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEALEK
MMAR_1634|M.marinum_M FLMMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEALEK
Mb3085|M.bovis_AF2122/97 FLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESLEQ
Rv3059|M.tuberculosis_H37Rv FLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESLEQ
MSMEG_2289|M.smegmatis_MC2_155 FLMMAAHDTSTSTMTTMAYHLAANPEWQDRLRDESERIGDGPLDIEALEK
Mvan_2031|M.vanbaalenii_PYR-1 FLMMAAHDTSTSTMTTMAYHLAANPEWQDRLREESARIGDGPLDIEALEK
Mflv_4315|M.gilvum_PYR-GCK FLMMAAHDTSTSTLTTMAYHLAANPEWQDRCREESERIGDGPLDIEALEK
TH_2954|M.thermoresistible__bu FLMMAAHDTSTSTMTTMAYYLAANQDWQQRCRDESDRLGDGPLDIEALEK
MAV_3927|M.avium_104 FLMMAAHDTSTSTTTTMVYNMAAHPEWQERAREESTRLGDGPLDIEALEK
MAB_3423|M.abscessus_ATCC_1997 FLMMAAHDTTTSTTTTMAYYLAANPEWQERVRDESDRLGDGPLDIDSLEK
MLBr_02088|M.leprae_Br4923 LLLVAGHETTVNLIANAVLAMLRNPSQWKALSSNPQRAP-----------
:*::*.*:*:.. :. . : : . . .:. *
MUL_3402|M.ulcerans_Agy99 LESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNH
MMAR_1634|M.marinum_M LESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNH
Mb3085|M.bovis_AF2122/97 LESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNH
Rv3059|M.tuberculosis_H37Rv LESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNH
MSMEG_2289|M.smegmatis_MC2_155 LETYDLVINEALRMMTPLPFNFRQAVRDTELLGYFIPAGTNVVTWPSINH
Mvan_2031|M.vanbaalenii_PYR-1 LETYDLVINEALRMMTPLPFNFRQAIRDTDLLGYYIPAGTNVVTWPSINH
Mflv_4315|M.gilvum_PYR-GCK LETYDLVINEALRMVTPLPFNFREAVRDTELLGYYIPAGTAIMTWPALNH
TH_2954|M.thermoresistible__bu LESLDLVMNESLRLVTPLPFNVRQTVRDTDLLGYYIPAGTNVVTWPGMNH
MAV_3927|M.avium_104 LETLELIMNESLRMVTPLPFNMRQAVRDTELLGHYIPAGTNITIWPGMNH
MAB_3423|M.abscessus_ATCC_1997 LESLDLVMNEALRLVTPLPFNIRSTVRDTDLLGFHIPAGTMINIWPGMNH
MLBr_02088|M.leprae_Br4923 -----LVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAAN
*:::*::* ..: * : :* : :. * : . :
MUL_3402|M.ulcerans_Agy99 RLPEFWTDPMTFDPDRFAEPRNEHKRHRYAFTPFGGGAHKCLGMVFGQLE
MMAR_1634|M.marinum_M RLPEFWTDPMTFDPDRFAEPRNEHKRHRYAFTPFGGGAHKCLGMVFGQLE
Mb3085|M.bovis_AF2122/97 RLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFGQLE
Rv3059|M.tuberculosis_H37Rv RLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFDQLE
MSMEG_2289|M.smegmatis_MC2_155 RLPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFGQLE
Mvan_2031|M.vanbaalenii_PYR-1 RLPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFGQLE
Mflv_4315|M.gilvum_PYR-GCK RLPELWTDPEKFDPARFAEPRNEHKKHRYAFAPFGGGAHKCIGMVFGQLE
TH_2954|M.thermoresistible__bu RLPELWTEPEKFDPERFAEPRSEHKRHRYAFAPFGGGAHKCIGMVFGQLE
MAV_3927|M.avium_104 RLPELWTDPDKFDPERFAEPRAEHKKHRYAFAPFGGGAHKCIGMVFGQLE
MAB_3423|M.abscessus_ATCC_1997 RLPELWTEPDKFDPDRFSEPRNEHKRHRYAFSPFGGGAHKCIGMVFGQLE
MLBr_02088|M.leprae_Br4923 RDPAVYSRPDEFDPDRPSS----------RHLAFAVGSHFCLGAALARLE
* * .:: * *** * :. . .*. * * *:* .: :**
MUL_3402|M.ulcerans_Agy99 IKTILHRLLRRYRLELARPDYRACWDYGGMPVPKDGMPIVLRPL-
MMAR_1634|M.marinum_M IKTILHRLLRRYRLELARPDYRACWDYGGMPVPKDGMPIVLRPL-
Mb3085|M.bovis_AF2122/97 IKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR-
Rv3059|M.tuberculosis_H37Rv IKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR-
MSMEG_2289|M.smegmatis_MC2_155 IKTVMHRLLRQYRLELPRPGYTPRYDYGGMPVPIDGMPIVLRPLR
Mvan_2031|M.vanbaalenii_PYR-1 IKTVVHRLLQNYRLELPRPDYQPRYDYGGMPVPLDGMPIVLRPLH
Mflv_4315|M.gilvum_PYR-GCK IKTVMHRLLRKYRLEPVSPNYRPRYDHGGMAVPIDGMPIVLRPLH
TH_2954|M.thermoresistible__bu IKTVMHRLLREYRLELPRPGYTPRYDYGGMPIPMDGMPIVLRRLR
MAV_3927|M.avium_104 VKTVVHRLLRRYRLELARPGYQPRWDYGGMPIPMDGMPIVLRPL-
MAB_3423|M.abscessus_ATCC_1997 IKAVMHRLLRRYRFELAHPHYQPKWDYAGMPLPIDGMPIILRPLH
MLBr_02088|M.leprae_Br4923 ATVTLSAISARFPQVQLAGELVYKPN-----VAMRGMSALPVQV-
.. : : .: : :. **. :