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VDHRQPFPPLPHPPRRVPVVGDVFGFSADILTRPPSDPGLGPVFEFRFLGARYVVAASADAVAEVNDERR FCKHVGPDIDALRIMGGDGLFTAYNEEPNWQRAHDLLMPAFSQQAMRGYHSAMLDAADGLVARWDGKART GASVDVPADATRVTLETIGQCAAGHPFGCFDTEDPHPFVEHMVAGLKGSDWVGVLRETVLPNFFARRAER RVRRHAVQMHRIADEIVSERLRDGLGHHDDLLELMLTSDLDPANIRYQLINFLVAGHETTSGALSFALYF LSRHPEVADRARAEVAEVWGDDERPGFELIAKLRYVRRVLDEALRLQPTVPGYYREAREDTVLAGVHPMR QGDWVLAMTMALHRDPRWGGDPDAFDPDRFAPDRVRARPAGLYKPFGTGPRSCIGRQFALHEAVLLLAVL LRRYDLVPEPGYQLQVAQRLTLMPKDFRLTLRRRRSE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4801 | - | - | 100% (458) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_0056 | - | 1e-41 | 33.90% (351) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_1596 | - | 4e-22 | 23.88% (381) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1429c | cyp132 | 2e-37 | 28.34% (434) | cytochrome P450 132 |
| M. tuberculosis H37Rv | Rv1394c | cyp132 | 1e-37 | 28.97% (435) | cytochrome P450 132 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-10 | 28.33% (180) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1426 | - | 8e-33 | 28.05% (410) | putative cytochrome P450 |
| M. marinum M | MMAR_0281 | cyp183B1 | 5e-41 | 28.76% (459) | cytochrome P450 183B1 Cyp183B1 |
| M. avium 104 | MAV_0708 | - | 7e-25 | 25.14% (358) | cytochrome P450 51 |
| M. smegmatis MC2 155 | MSMEG_0968 | - | 8e-42 | 33.99% (353) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3255 | - | 1e-40 | 32.85% (347) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 4e-34 | 29.78% (366) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_0858 | - | 3e-37 | 32.17% (345) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1429c|M.bovis_AF2122/97 ---------------------MATATTQRPLKGPAKRMSTWTMTREAITI
Rv1394c|M.tuberculosis_H37Rv ---------------------MATATTQRPLKGPAKRMSTWTMTREAITI
MSMEG_0968|M.smegmatis_MC2_155 MVSDVPAVTAPPGRSADASGANAKPDTGALPLAPRNPLSLRQMARAVR--
Mvan_0858|M.vanbaalenii_PYR-1 ---------------MTARDTAAAPEVGSLPLVPRNPLPLWKLVQLVR--
TH_3255|M.thermoresistible__bu -----------------MVVTTERADVATLPPAPRNPLPYWRQVRAVR--
MUL_0604|M.ulcerans_Agy99 --------------------MVDPPDIRSLPLAPRNPLPYWQQLKALK--
MAB_1426|M.abscessus_ATCC_1997 ---MSASALQPEPLSAPVEVAAGECPVNHDLYPGGPTFLRWHHTRVGYLK
MMAR_0281|M.marinum_M -------------------------MPTSIPIAPAALPLLGHTLPLLR--
Mflv_4801|M.gilvum_PYR-GCK -------------------MVDHRQPFPPLPHPPRRVPVVGDVFGFSA--
MAV_0708|M.avium_104 -----------------------MTTSTVVPRVSGGEEEHGHLEEFRT--
MLBr_02088|M.leprae_Br4923 -------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLID
Mb1429c|M.bovis_AF2122/97 GFDAGDGFLGRLRGSDITRFRCAG---------RRFVS----ISHPDYVD
Rv1394c|M.tuberculosis_H37Rv GFDAGDGFLGRLRGSDITRFRCAG---------RRFVS----ISHPDYVD
MSMEG_0968|M.smegmatis_MC2_155 ALDMGQQVIRAAGG-AVTRVQFGP---------RWLVPPLVAVFSPEGIR
Mvan_0858|M.vanbaalenii_PYR-1 RLDTGQEVIRDAGG-PITRIQLGP---------KKLMPPIVAVMSPAGMR
TH_3255|M.thermoresistible__bu SFHTGQELLRDAGG-PVK----------------WAIPPIVLVTSPAGIR
MUL_0604|M.ulcerans_Agy99 TLHVGSEALRDAGG-SVTRIWLGP---------KRLVPPMVMVTSPQGAR
MAB_1426|M.abscessus_ATCC_1997 SWRLALGAVWSTYRHTISEYLADLPGQDDVIVARAPMRKAVIVRNPELAR
MMAR_0281|M.marinum_M --NPLSFLLSLPARGDLVRIRIGP-------------ATAVVACTAELTH
Mflv_4801|M.gilvum_PYR-GCK --DILTRPPSDPGLGPVFEFRFLG-------------ARYVVAASADAVA
MAV_0708|M.avium_104 -DPIGLMQRVRDECGDVGWFQLVD-------------KHVILLSGAQANE
MLBr_02088|M.leprae_Br4923 PGTRADPFPVYRALIDYGPMQLPG---------MPLTVFSSFSDCDEALR
Mb1429c|M.bovis_AF2122/97 HVLHEAR---LKYVK--SDEYGPIRATAGLNLLTDEGD--SWARHRGALN
Rv1394c|M.tuberculosis_H37Rv HVLHEAR---LKYVK--SDEYGPIRATAGLNLLTDEGD--SWARHRGALN
MSMEG_0968|M.smegmatis_MC2_155 DVLGRND---AFAER--CIVHDEVRHAAGDSLFVLPNE--QWRPRKRALQ
Mvan_0858|M.vanbaalenii_PYR-1 DVLGRND---ASSDR--CIIHEQVQEMAGDSLWVLPNE--QWRPRKRALA
TH_3255|M.thermoresistible__bu DVLNRRD---ALSER--CQVHHEVRHLGGDSLFVLPTD--PWRARRRALA
MUL_0604|M.ulcerans_Agy99 DVLGRSG---ALSDRGTLPLLKDLRRAIGESVLNLPHD--TWLPRRRTLQ
MAB_1426|M.abscessus_ATCC_1997 HVLVANQ---DNYIK--SAEYDLLAVGFGRGLVTDLNEG-LWNRNRRLVQ
MMAR_0281|M.marinum_M EILCDDR---IFDKG--GIFFDRFREMLGDGLGTCPRS--QHRRQRRLLQ
Mflv_4801|M.gilvum_PYR-GCK EVNDERR---FCKHVG--PDIDALRIMGGDGLFTAYNEEPNWQRAHDLLM
MAV_0708|M.avium_104 FFFRSAD---EDLDQ--AEAYPFMTPIFGKGVVFDASP---ERRKEMLHN
MLBr_02088|M.leprae_Br4923 HPLSASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPP--DHTRLRKLVS
. .. .
Mb1429c|M.bovis_AF2122/97 STFARRHLRGLVGLMIDPIADVTAALVP------GAQFDMHQSMVETTLR
Rv1394c|M.tuberculosis_H37Rv STFARRHLRGLVGLMIDPIADVTAARVP------GAQFDMHQSMVETTLR
MSMEG_0968|M.smegmatis_MC2_155 PVFTKHSVRAFGGHMSRAAQTLVDEWADQWAQADSLEVDLDAVCRRVTMQ
Mvan_0858|M.vanbaalenii_PYR-1 PVFTKTSVRAFGGHMSKAAQAFVDRWP------SGGEVDLDAECRRVAMQ
TH_3255|M.thermoresistible__bu PVFTPTAVRSYGGYMSEAAQRVADGWQ------AAREVDLDAECRRLTMR
MUL_0604|M.ulcerans_Agy99 PIFTKQRVAGFAGHMSEAANHILLGWP------DGAEVDLNAASHALVLR
MAB_1426|M.abscessus_ATCC_1997 PIFAKRQVDLFAPQMAEAAARTISRWDELYAE--GKPVDITAEMNYLTMD
MMAR_0281|M.marinum_M PAFHTQRLPGYAQTMTTEVAATVGRWQN------GQIIDVPAEMMAITGR
Mflv_4801|M.gilvum_PYR-GCK PAFSQQAMRGYHSAMLDAADGLVARWDG--KARTGASVDVPADATRVTLE
MAV_0708|M.avium_104 SALRGEQMKGHASTIEGEVKKMIADWGD------EGEIELLDFFAELTIY
MLBr_02088|M.leprae_Br4923 KAFAPKVVQALEGDIAALVDSLLDKGAA------AGQFDVIADLAFPLAV
: : : .::
Mb1429c|M.bovis_AF2122/97 VVANALFSQDFG----PLVQS--MHDLATRGLRRAEKLERLGLWGLMPRT
Rv1394c|M.tuberculosis_H37Rv VVANALFSQDFG----PLVQS--MHDLATRGLRRAEKLERLGLWGLMPRT
MSMEG_0968|M.smegmatis_MC2_155 SLGRSVLGIDLNERADVIVEH--MHVASSYATDRALRPLRAPRWLPTP--
Mvan_0858|M.vanbaalenii_PYR-1 SLGRSVLGVDLNERGETIARC--MHVASSYTADRALRPVRAPRWLLTP--
TH_3255|M.thermoresistible__bu SLGRSVLGLDINERADAISEP--MHIASSYTADRALRPVRAPRWLPTP--
MUL_0604|M.ulcerans_Agy99 VVGHSVFGLDLQDKADVITTG--VTLAAKWAADRSARPVRAPHWLPTP--
MAB_1426|M.abscessus_ATCC_1997 IVAQTMFGIDLSGDMAERMRIYFARLLKLFGVGFIVGAAPPLRWVVDKLA
MMAR_0281|M.marinum_M TLLATMFSNSLPNPALRQALD---DLTAIFAVLYWRMLTPPPLDRLPT--
Mflv_4801|M.gilvum_PYR-GCK TIGQCAAGHPFGCFDTEDPHPFVEHMVAGLKGSDWVGVLRETVLPNFFAR
MAV_0708|M.avium_104 TSTACLIGLKFREQLDHRFAEYYHDLERGTDPLCYVDPYLPIESFKRR--
MLBr_02088|M.leprae_Br4923 AVICRLLGVPYEDAPEFGRVS--ALLVQSVDPFITITGEPPE--------
.
Mb1429c|M.bovis_AF2122/97 VYDT------------LIWCIYSGVHLPPPLREMQEITLTLDRAINSV-I
Rv1394c|M.tuberculosis_H37Rv VYDT------------LIWCIYSGVHLPPPLREMQEITLTLDRAINSV-I
MSMEG_0968|M.smegmatis_MC2_155 ----------------------ARRRARAAVAAMRAVTAEILQACRDD-A
Mvan_0858|M.vanbaalenii_PYR-1 ----------------------ARQRARSAVNAMRAITDEMVKACRDD-P
TH_3255|M.thermoresistible__bu ----------------------ARRRARAAVATMRRITDEMLQACRAD-P
MUL_0604|M.ulcerans_Agy99 ----------------------ARPRARGAYDAMYKIAADMLAACRAD-P
MAB_1426|M.abscessus_ATCC_1997 AHGPDELSSHTPRLAIRALRIGASVAAPRTMKGLRWVERTIDQLIADHRS
MMAR_0281|M.marinum_M ---------------------VGNRRYHRASARLRHTIGSAVAGRRAAGV
Mflv_4801|M.gilvum_PYR-GCK ---------------------RAERRVRRHAVQMHRIADEIVSERLRDGL
MAV_0708|M.avium_104 -----------------------DEARVKLVALVQEIMDQRLANPPKDKA
MLBr_02088|M.leprae_Br4923 ----------------------ATEERLRAGVWLRDYLEQLVKCRRGTPG
:
Mb1429c|M.bovis_AF2122/97 DRRLAEPTNSADLLNVLLSADGGIWPRQRVRDEALTFMLAGHETTANAMS
Rv1394c|M.tuberculosis_H37Rv DRRLAEPTNSADLLNVLLSADGGIWPRQRVRDEALTFMLAGHETTANAMS
MSMEG_0968|M.smegmatis_MC2_155 DR---DAPLVRALMAAEDPETGERLSDEDICNDLLIFMLAGHDTTATALT
Mvan_0858|M.vanbaalenii_PYR-1 TR---DAPLVQALIAATDPETGRPLTDEEISNDLLIFMLAGHDTTATALT
TH_3255|M.thermoresistible__bu DR---DAPLVHALIRATDPETGRGLSDEDICNDLLIFMLAGHDTTATALT
MUL_0604|M.ulcerans_Agy99 SR---EAPLITALIDATGPNTGESLSDQQICDEMVYFMILGEDTTSTVLT
MAB_1426|M.abscessus_ATCC_1997 GRIARQDNLLALLMAAEDPETGAKYTDLEIRDELMTFLGAGFETTAAALA
MMAR_0281|M.marinum_M DR---GDLLSAILASHEVDSSTVAFTDTEVIDQIVSFFIAGTETTALTVA
Mflv_4801|M.gilvum_PYR-GCK GH--HDDLLELMLTSDLDPAN--------IRYQLINFLVAGHETTSGALS
MAV_0708|M.avium_104 DR-----DMLDVLVSIKDEDGKPRFSADEITGMFISLMFAGHHTSSGTSA
MLBr_02088|M.leprae_Br4923 ED------LISRLIELD--ESGDQLTEEEIIATCGLLLVAGHETTVNLIA
* : :: * .*: :
Mb1429c|M.bovis_AF2122/97 WFWYLMALNPQARDHMLTELDDVLGMRR-PTADDLGKLAWTTACLQESQR
Rv1394c|M.tuberculosis_H37Rv WFWYLMALNPQARDHMLTELDDVLGMRR-PTADDLGKLAWTTACLQESQR
MSMEG_0968|M.smegmatis_MC2_155 YALWALGHHPEIQDRVAAEAR-ALGDRE-LTPADVPQLGYTVQVLHESLR
Mvan_0858|M.vanbaalenii_PYR-1 HALWVLGHHPDIQDRVAAEAA-AIGDRE-LTPDDVPALGYTVQVLHESVR
TH_3255|M.thermoresistible__bu YALWALGHHPEIQDRVAAEVA-ELPDRE-ITPHDVPRLGYTVQVLRESLR
MUL_0604|M.ulcerans_Agy99 YALWALGQHCQLQDRLAAEAA-ELGDRP-LTPADVPRLGYTIQVLQEAMR
MAB_1426|M.abscessus_ATCC_1997 WTWYLLSRNPDARAKLGQEVDRVLGGRQ-PTAADVDNLPWTAAVLNEAMR
MMAR_0281|M.marinum_M WALYLLAEHPAIEQRVHAEIDPVLAGRA-ATHADLPRLGLVNRIVTETLR
Mflv_4801|M.gilvum_PYR-GCK FALYFLSRHPEVADRARAEVAEVWGDDERPGFELIAKLRYVRRVLDEALR
MAV_0708|M.avium_104 WTLIELIRHPDVYAEVLAELEELYADGQEVSFHALRSIPKLDNVVKETLR
MLBr_02088|M.leprae_Br4923 NAVLAMLRNPSQWKALSSNPQ------------------RAPLVVEETLR
: : : : *: *
Mb1429c|M.bovis_AF2122/97 YFSSVWIIAREAVDDDIIDG-HRIRRGTTVVIPIHHIHHDPRWWPDPDRF
Rv1394c|M.tuberculosis_H37Rv YFSSVWIIAREAVDDDIIDG-HRIRRGTTVVIPIHHIHHDPRWWPDPDRF
MSMEG_0968|M.smegmatis_MC2_155 MCPPAAGVGRLALRDIAVAG-HRVEAGSLVALGIYAVHHDPQLWPDPEVF
Mvan_0858|M.vanbaalenii_PYR-1 LCPPAAGVARLVTRDFAVDG-YRVEAGSLVALGLYALHHDPALWPDPMAF
TH_3255|M.thermoresistible__bu LCPPAAGVGRLAMSDLAVDG-YRVEAGTLLAVGIQAIHRDPSLWPDPMVF
MUL_0604|M.ulcerans_Agy99 LRPPGPTVARRAMQDIEVDG-YRVQAGTYCLVGVYAMHRDPALWDDPLAF
MAB_1426|M.abscessus_ATCC_1997 VYPPILGLARTAKADDVLGD-YPISAGTTVMVLIDSIHHNERVWDDAKTF
MMAR_0281|M.marinum_M LYPPGWIISRVATADVYLGG-HRIPAGATVIFSPYLIHHRPDLYAEPERF
Mflv_4801|M.gilvum_PYR-GCK LQPTVPGYYREAREDTVLAGVHPMRQGDWVLAMTMALHRDPRWGGDPDAF
MAV_0708|M.avium_104 LHPPLIILMRVAKGEFEVEG-FPIHEGDYVAASPAISNRIPEDFPDPDAF
MLBr_02088|M.leprae_Br4923 YDPAIHLIGRVAAKDMTIGQ-TTLTEGDTMVLLLAAANRDPAVYSRPDEF
.. * . : : : * :: . *
Mb1429c|M.bovis_AF2122/97 DPGRFLR-CPTDRP-RCAYLPFGGGRRICIGQSFALMEMVLMAAIMSQHF
Rv1394c|M.tuberculosis_H37Rv DPGRFLR-CPTDRP-RCAYLPFGGGRRICIGQSFALMEMVLMAAIMSQHF
MSMEG_0968|M.smegmatis_MC2_155 DPDRFSPENSRERD-RWHFIPFAGGARACIGEHFARLETTLALATIIRSV
Mvan_0858|M.vanbaalenii_PYR-1 DPDRFSPENVKARD-RWQFLPFLGGGRPCIGEHFARLETTLALATVVRAC
TH_3255|M.thermoresistible__bu DPDRFAPERFKAMD-RWQFVPFIGGPRSCIGEHFAMLESTLAIATLIRSV
MUL_0604|M.ulcerans_Agy99 DPDRFAPKKSKGRD-RWQYLPFGGGGRSCLGDHFAMLEASLALATIIREA
MAB_1426|M.abscessus_ATCC_1997 DPARFLKENLQPEQ-RKAHMPFGAGKRMCVASGFANLEAIIGIAALAQNY
MMAR_0281|M.marinum_M DPDRWLPERARAIG-RNTYIPFGGGARKCIGDNFGTTEAALALATIAANW
Mflv_4801|M.gilvum_PYR-GCK DPDRFAPDRVRARP-AGLYKPFGTGPRSCIGRQFALHEAVLLLAVLLRRY
MAV_0708|M.avium_104 KPDRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREY
MLBr_02088|M.leprae_Br4923 DPDRPSS----------RHLAFAVGSHFCLGAALARLEATVTLSAISARF
.* * .* * : *:. :. : : :
Mb1429c|M.bovis_AF2122/97 TFD-LAPGYH-VELEATLTLRPKHGVHVIGRRR-----------------
Rv1394c|M.tuberculosis_H37Rv TFD-LAPGYH-VELEATLTLRPKHGVHVIGRRR-----------------
MSMEG_0968|M.smegmatis_MC2_155 VVGSVDAEFP-VDVPFTTVAKGPIRANVAPRGPDHYTL------------
Mvan_0858|M.vanbaalenii_PYR-1 RIESLDDLFE-CEVPLTTVAKGPIRARVTPRR------------------
TH_3255|M.thermoresistible__bu RIRSLDDDFP-VEVPFTTVARGPIRAVVSARR------------------
MUL_0604|M.ulcerans_Agy99 EIHSLDGDFP-VAIPLPIVPAGPIRARVNQRRPSQEVCTTTLSDSSASS-
MAB_1426|M.abscessus_ATCC_1997 ELDLLPGQQPRREVTFTGGPEGEILMRLRKRHP-----------------
MMAR_0281|M.marinum_M RMQRLPGLPVRPAVAASLRPRN-LALRVTARTADRVPGEPGRRLTSREIG
Mflv_4801|M.gilvum_PYR-GCK DLVPEPGYQLQVAQRLTLMPKDFRLTLRRRRSE-----------------
MAV_0708|M.avium_104 DFEMAQPADSYRNDHSKMVVQLARPAKVRYRKRNA---------------
MLBr_02088|M.leprae_Br4923 PQVQLAGELV-YKPNVAMRGMSALPVQV----------------------