For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
EIDVTGIACRFPGADGVEAFWDMLLRGRNGTRVVPEDRWWADDFVSPAPPYGTGKVNTRHGAFIDDPERF DHGFFGIAPSEAAATDIQQRLVLQAGYHALEDAGIDPQSLRGSTTGVFVGVMSSDWGALHLTDYAGMTPQ RGVGNGYCMLANRVSYALDLTGPSMSVDTACSSSLTAVHLAAGALRAGECDLAIVAGVNLMLTPILSIFY TQAGLSAPDGRCRPFAKSGGGIGRGEGVGAVVLRRSEDRPDDAPAPYATVRGSFVGQDGRSNGITAPTRR GQERVIAAALRSAGHTGADLHFVEAHGTGTTLGDLIETQALGATCGDRVGRAPLVVGSVKGNIGHTEGAA GIAGFIKACLSMHHRTVPPSLFADDENPALDLAERNLKLAVSAEKLPRGDLLAGVSSFGLGGTNVHVVIG SAPRVRRPIRRGGIGVLTVSGNDAAALRRNLDRLVAGFDPTEHWPRYCYSTNQVKAGGTQRIALVTRDGA DLAGEAEVALHRLARRNERARRRRPRIAFVYTGQGSQYREMGLALREQHSGFAEALAEADALLEPHFGGS VVRAIETGEDHLGRSLDDTVVAQPALFALQYALTTTFAAHGVRPDVVLGHSVGEIAACAAAGVLDPAAAA ALVVTRGALMGALPAGGTMLAARLPAELADEFVSGPVALAAVNGPDSVTFSGPVERIAEVADQLNGRGVH TRELVVSHAFHSPAMEPVGGELAAAAPLPAESAGAPIVISSVTGTAAEAADFTGDYWRAQLLGTVDFLGA ARTLADMEPSHIIEIGPRSTLLSLLAAADLIPDSQRIAPVPGAAATGLDFADALAALWQWGLDIDWRPLY AEHDRVVGRLPGYVFADEERFFASAATVGPLVHTQSVRTATAPVREVASVPPADDESQPDVGVVHRAVIR VLADVGGHREDALHAAADLRDDLGFDSVQAMQFADRIVNELDMPRLDPVAIQDNLTTIADLTKLVAGTAG VAQPEHTGAGI*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_3575c | - | - | 100% (992) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | e-137 | 39.43% (842) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_2212 | - | e-123 | 36.75% (819) | polyketide synthase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2074c | pks12 | 1e-150 | 40.25% (887) | polyketide synthase pks12 |
M. gilvum PYR-GCK | Mflv_0405 | - | 1e-142 | 37.99% (916) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv2048c | pks12 | 1e-150 | 40.14% (887) | polyketide synthase pks12 |
M. leprae Br4923 | MLBr_00135 | - | 1e-151 | 39.69% (897) | putative polyketide synthase |
M. marinum M | MMAR_0101 | - | 1e-151 | 40.36% (892) | polyketide synthase PKS |
M. avium 104 | MAV_3108 | - | 1e-153 | 40.65% (888) | erythronolide synthase, modules 3 and 4 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 1e-138 | 36.29% (981) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4458 | - | 1e-124 | 40.38% (676) | PUTATIVE putative Fatty acyl-AMP ligase FadD28_1 and polyketide |
M. ulcerans Agy99 | MUL_2005 | pks15/1 | 1e-146 | 38.80% (902) | polyketide synthase Pks15/1 |
M. vanbaalenii PYR-1 | Mvan_1003 | - | 1e-144 | 38.75% (898) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0405|M.gilvum_PYR-GCK ----------------------MGSAAHQGE-SAHRFAIVGYAGRFPG-A MSMEG_0408|M.smegmatis_MC2_155 ----------------------MVSAEHPIE-PTPSFAIIGYAARFPG-A Mvan_1003|M.vanbaalenii_PYR-1 --------MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYALRFPG-A MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGV Rv2048c|M.tuberculosis_H37Rv MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGV MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVVTRRAGFV MSMEG_0408|M.smegmatis_MC2_155 ASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVVTRRAGFV Mvan_1003|M.vanbaalenii_PYR-1 ADADEFWDVLRGGRDAISEVPQDR-WDADEFFDADPEAAGKMVTRRAGFV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 DSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFV Rv2048c|M.tuberculosis_H37Rv DSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFV MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANTN MSMEG_0408|M.smegmatis_MC2_155 DDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANSN Mvan_1003|M.vanbaalenii_PYR-1 EDVAGFDAPFFGVSAREAMFMDPQHRLLLETAWRAVEHSGTAPSALAGTR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 DGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSA Rv2048c|M.tuberculosis_H37Rv DGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSA MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQG MSMEG_0408|M.smegmatis_MC2_155 TGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQG Mvan_1003|M.vanbaalenii_PYR-1 TGVFMGLSTHDYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRISYRLGLQG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 TGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLEG Rv2048c|M.tuberculosis_H37Rv TGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLEG MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVILTPATMITFSN MSMEG_0408|M.smegmatis_MC2_155 PAVAVDTACSSSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFSN Mvan_1003|M.vanbaalenii_PYR-1 PAVAVDTACSSSLVAVHQACQALRLAECDVALAGGVNVLLSPATMINFSR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 PAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSR Rv2048c|M.tuberculosis_H37Rv PAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSR MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIRG MSMEG_0408|M.smegmatis_MC2_155 AHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIRG Mvan_1003|M.vanbaalenii_PYR-1 ARMLAPDGRCKTFDATADGYVRGEGCGVVVVKRLADAIRHGDRIRAVIRG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 HRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVG Rv2048c|M.tuberculosis_H37Rv HRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVG MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SAINQDGASGGLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTSL MSMEG_0408|M.smegmatis_MC2_155 SAINQDGASGGLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTSL Mvan_1003|M.vanbaalenii_PYR-1 SAVNQDGASGGLTVPNGAAQQRVIADALTNAGLTAADVDYLEAHGTGTPL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 SAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTL Rv2048c|M.tuberculosis_H37Rv SAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTL MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GDPIEAQAAGAALGPGREPQRPLLIG-SAKTNIGHLEAAAGIAGVIKVVL MSMEG_0408|M.smegmatis_MC2_155 GDPIEAQAAGEVLGAGRAPEEPLLIG-SAKTNIGHLEAAAGIAGVIKVVM Mvan_1003|M.vanbaalenii_PYR-1 GDPIEVQAAGAVLGVGREPDRPLLIG-SVKTNIGHLEAASGIAGLLKVIL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 GDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVL Rv2048c|M.tuberculosis_H37Rv GDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVL MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SLEHETLPKHLNFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPRIAGV MSMEG_0408|M.smegmatis_MC2_155 ALENETLPKHLNFETPSPHIPWERLPIEVVRETVPWQR---NGKPRIAGV Mvan_1003|M.vanbaalenii_PYR-1 SLEHQVLPKHLNFRSPSPHIPWNRLPVRIVDDPVPWTR---SGRSRVAGI MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 AMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAG---ARTRRAGV Rv2048c|M.tuberculosis_H37Rv AMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAG---ARTRRAGV MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SSFGFAGTNAHVILEEAPLAAEPAQES--VDDGRFTLLPLSARTPAALMA MSMEG_0408|M.smegmatis_MC2_155 SSFGFAGTNAHVILEEAPAVGTPATTEPVEDPRRYSVLPLSARTPEALVR Mvan_1003|M.vanbaalenii_PYR-1 SSFGFSGTNAHVLVEEAPRADRAGAAPQPAAPGGFGMLPLSARTPDALAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 SSFGISGTNAHVIIEAVPVVPRREAGWAGPVVP-----WVVSAKSESALR Rv2048c|M.tuberculosis_H37Rv SSFGISGTNAHVIIEAVPVVPRREAGWAGPVVP-----WVVSAKSESALR MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VADRYRDWLVANPDATLADLCFTAGTARSHLEHRAALVVNTREAALDLLG MSMEG_0408|M.smegmatis_MC2_155 LAGEYRDWLRAHPQARLADVSHTAGTARAHLEQRAALVVNSRESAIELLG Mvan_1003|M.vanbaalenii_PYR-1 TAHRLRTWLAANPDASWPDLCFTAAVGRSHLRHRAALVVDSRSSVEELLG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 GQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGLD Rv2048c|M.tuberculosis_H37Rv GQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGLD MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ALADDRPAPGLVRGESHDTPKTAWLFTGQGSQYPGMSRELFDTEPLFAET MSMEG_0408|M.smegmatis_MC2_155 ALADDRPAPGLVRGESHEAPKTAWLFTGQGSQYPGMARELFDTEPVFAET Mvan_1003|M.vanbaalenii_PYR-1 ALAEDRPGPGLARGECGDPPKTAWLFTGQGSQYPGMGRELFDTEPVYREV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQ Rv2048c|M.tuberculosis_H37Rv ELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQ MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LRECAAAVDGMLEKPLLDVIFDTDGVLDTDSNETLRHTSYAQPALFAVEM MSMEG_0408|M.smegmatis_MC2_155 VRKCAEAVADILEKPLLDVIFDAD-ELDGDTESPLRHTTYAQPALFAVEL Mvan_1003|M.vanbaalenii_PYR-1 MTRCAEAVADVLERPLLDVVFDAD------GGEALRHTSYAQPALYAVEM MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 IDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPVLFAVMV Rv2048c|M.tuberculosis_H37Rv IDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPVLFAVMV MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GLARLWQSWGFEPDVVLGHSVGQYAAACVAGVLSLRDGARLMAERGRLFG MSMEG_0408|M.smegmatis_MC2_155 GLARLWQSWGFEPDVVVGHSVGQYSAACVAGVFDVEDGARLIAERGRLFG Mvan_1003|M.vanbaalenii_PYR-1 GLARLWQSWGIEPDVVLGHSVGQYAAACVAGVMGLEDGAVLLAERGRLFG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 SLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLA Rv2048c|M.tuberculosis_H37Rv SLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLA MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 GLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSGEVGALE Rv2048c|M.tuberculosis_H37Rv GLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSGEVGALE MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVF Rv2048c|M.tuberculosis_H37Rv ELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVF MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 FSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPH Rv2048c|M.tuberculosis_H37Rv FSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPH MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 PALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA Rv2048c|M.tuberculosis_H37Rv PALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 VNWRGTLDGAGYVELPTYAFDKRRFWLSAEGSGADVSGLGLGASEHPLLG Rv2048c|M.tuberculosis_H37Rv VNWRGTLDGAGYVELPTYAFDKRRFWLSAEGSGADVSGLGLGASEHPLLG MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 AVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGFVELAIRAGD Rv2048c|M.tuberculosis_H37Rv AVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGFVELAIRAGD MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -----------------------------------------------SLP MSMEG_0408|M.smegmatis_MC2_155 -----------------------------------------------SLP Mvan_1003|M.vanbaalenii_PYR-1 -----------------------------------------------SLP MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 EVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSRGVSIFSRADAQ Rv2048c|M.tuberculosis_H37Rv EVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSRGVSIFSRADAQ MMAR_0101|M.marinum_M ---------------------------------------------MRNNN MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SGGRMAAVFAAAERVEALTDEYPALSVAAYNGANTVLSGPATDLERAVAG MSMEG_0408|M.smegmatis_MC2_155 AGGRMAAVFTAPERAERLTDEYPSLSVAAYNGANTVLSGPAKDLESAVAT Mvan_1003|M.vanbaalenii_PYR-1 EGGRMAAVFAPADRVESCTVDSPLLSVAAYNGDNTVLSGPAGDLERAVAG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 AGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRGYRYG Rv2048c|M.tuberculosis_H37Rv AGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRGYRYG MMAR_0101|M.marinum_M LAWLLANQALASEWSASPAYYAPNIVTHAQIHEGAARLGNVFGSRGLRTG MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------LLSLLRQRSERYGDKIAFDYCTGEQEHSRLTYQELDIR----- Mflv_0405|M.gilvum_PYR-GCK LVADGVRCDWLETSHAFHSALLDPILDDFESYARGITFTAPQRILIDNRT MSMEG_0408|M.smegmatis_MC2_155 LVADGVRCDWLDTSHAFHSALLDPILDDFESFAQKLEYREPQRILIDNRT Mvan_1003|M.vanbaalenii_PYR-1 FSAAGVRCDWLDTSHAFHSALLDPVLEEFESCADRFEFGTPQRTLVCNRS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 PAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAG Rv2048c|M.tuberculosis_H37Rv PAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAG MMAR_0101|M.marinum_M ---------------------------------------DRVLLCLPDST MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu ----------------------------ARAIAAHLQDQGVAGERVLVLC Mflv_0405|M.gilvum_PYR-GCK GAALGRSVTLDAAYWRRHARQPVEFAKSVHTLADMNCKLLVEIGPRPVLT MSMEG_0408|M.smegmatis_MC2_155 GSALGRSTRLDGAYWRRHARQPVEFAKSVRTLADMNCRVLLEIGPRPVLT Mvan_1003|M.vanbaalenii_PYR-1 GEVLSRHARLDGQYWRRHARQPVRFAESVRTLADLGCRLLMEIGPQPVLT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 DPDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLS Rv2048c|M.tuberculosis_H37Rv DPDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLS MMAR_0101|M.marinum_M DLVQLLLACLARGIVAFISNP---------------ELRPDDHTFQEQDT MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu PSGLDFITAMFGCFYVGAVAVPVHPPVHNRLLSRVASIVADVRATSVLTT Mflv_0405|M.gilvum_PYR-GCK AAALSAWPDPATSPRVIASLRRTTADQRQITEAVADAYVLGHLPRFAAFR MSMEG_0408|M.smegmatis_MC2_155 ATALAAWPDPATTPQVLASLRPTTADHRQITEAVAAAYAAGHLPDFRAFR Mvan_1003|M.vanbaalenii_PYR-1 AAAMRTWPGTVTAPRVAASMRRKGSDRRQITEALAQAYVAGHRPETAARQ MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 VASMVARPVTERQLLAAVSGSGPDRLFEVIWSPASAATSPGPTPAYQIFE Rv2048c|M.tuberculosis_H37Rv VASMVARPVTERQLLAAVSGSGPDRLFEVIWSPASAATSPGPTPAYQIFE MMAR_0101|M.marinum_M QPALVVTTDALRDRFARSGIVDPGELWAEANQAKPAAYEPLTGDALAYGT MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu AATRADLKEILDGLHDGDPLRWLAVDTIEADDETSWTPTTVDTDSVAFVQ Mflv_0405|M.gilvum_PYR-GCK RDGARVLDLPTYPFEHRQYWFSDSR------EPVAAAPQRGARTETVRLL MSMEG_0408|M.smegmatis_MC2_155 QPDARKLDLPTYPFEHRQFWFSDNRAIDRDTQTASAGSVTPHRTQAVRLL Mvan_1003|M.vanbaalenii_PYR-1 HGRGRLLDLPTYPFQHRAYWFPQGQ--------ARTAPTDPVHTETVRFL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 SVAADQDPVAGSYVRSHQALAAVQSWLTDHESGVLVVATRGAMALPREDV Rv2048c|M.tuberculosis_H37Rv SVAADQDPVAGSYVRSHQALAAVQSWLTDHESGVLVVATRGAMALPREDV MMAR_0101|M.marinum_M YTSGTTGAPKAALHRHGDVWAFIDAMCRN---ALRLTPDDVGLSIARMYF MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu YTSGSTSTPKGVVLTHHNLLANLESISRDAGQGDEARVVSWLPLHHDMGL Mflv_0405|M.gilvum_PYR-GCK EDGRIEELAALLGGTVDDPFTFDVLNRLAAQHNQQRSTESIADDRYQIRW MSMEG_0408|M.smegmatis_MC2_155 EDGQIEELAALIDGETVDEQTLRVLNKLAARHNQQRSTHVDPDARYEIRW Mvan_1003|M.vanbaalenii_PYR-1 DEERIDELAALLDGPTGSAQTVDVLSKLAARHRQQRGAQSIADARYQIRW MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVL Rv2048c|M.tuberculosis_H37Rv ADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVL MMAR_0101|M.marinum_M AYGLGNSVWFPLATGSSAVISRSPLGAESAAN--------LSERFSPSVL MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu IGGIFGVVHFGGTAYLMPPSSFIQRPMSWLEAISWHGANISVGPNFGYQL Mflv_0405|M.gilvum_PYR-GCK ETAAEPPVGADAADGITWLLVGDDTDATRPLVDVLAARGHRYRILGLPKS MSMEG_0408|M.smegmatis_MC2_155 DAIASAAASTGAAA--DWILVGDDTAAVLEFADALTAGGHRHQIVALPGS Mvan_1003|M.vanbaalenii_PYR-1 EKSEAPGAARPTTEATTWLLVTHDSRAAQPIAEVLERRGHPYHIVGLPGS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 RGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNAD Rv2048c|M.tuberculosis_H37Rv RGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNAD MMAR_0101|M.marinum_M YGVPTFLARVADTCAADAFR---------------------SLRCVVSAG MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu CVERSTPEERATLDLSTWVRAYCGAEPVRAATMRRFTEAFAPAGFRADAF Mflv_0405|M.gilvum_PYR-GCK GAEEHELADTLRD------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 DADEAQLVDTLR-------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 DADAAPAEEALR-------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 APLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPGV Rv2048c|M.tuberculosis_H37Rv APLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPGV MMAR_0101|M.marinum_M EALELGLAQRLMKFFGG--------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu HPVYG--------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK --------------------------AAADATDLRIVHVAALDAAESDTS MSMEG_0408|M.smegmatis_MC2_155 ---------------------------AASAGELYVVHIAAGDGAAAP-- Mvan_1003|M.vanbaalenii_PYR-1 --------------------------ATVSQPRPHILYLAALEEPGGS-A MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 TEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTA Rv2048c|M.tuberculosis_H37Rv TEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTA MMAR_0101|M.marinum_M ----------------------------IPLLDGIGSTEVGQTFISSTVD MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -----------------------------------LAEATLFVSGRPENV Mflv_0405|M.gilvum_PYR-GCK MKSLLRMQHRVLGGTRRLFGAAVAAQLRSPMWLVTRGAQHVTDTDVVAPD MSMEG_0408|M.smegmatis_MC2_155 MRDLLRVQHRTLGGLRRLFRAANDAELRSPIWLVTRDGQRVTDTDTVVPE Mvan_1003|M.vanbaalenii_PYR-1 AETLGWMQHRVLAAARRLFQLAATAGARAPIWLITAGAQRITGDETVEPA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 YYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWD Rv2048c|M.tuberculosis_H37Rv YYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWD MMAR_0101|M.marinum_M EWRLGTLGKVLSPYEIRVVAPDG--------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu LPTVRSLDNAALREHRVVPAAADDANAAAVVGCGPAAYGEEIVIVDPATR Mflv_0405|M.gilvum_PYR-GCK QTCLWGFGRAASLEHPQIWGGLADLGGGTSDEWSRLLNRIAATHDP---- MSMEG_0408|M.smegmatis_MC2_155 QSCLWGFGRAAALELPHIWGGLADLSG-ADTEWPRLIARITSPRD----- Mvan_1003|M.vanbaalenii_PYR-1 QTSLWGFGRAAALEQPELWGGLADVTTGDAEEWSALIDHIVAAPT----- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 TLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLR Rv2048c|M.tuberculosis_H37Rv TLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLR MMAR_0101|M.marinum_M TTAAPGVEGDLWVRGPSLTAGYWNRPTQPPSISDSWLDTRDRVCVDAHG- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu REFPPDVVGEIWVAGENVAQGYLGKPSESAETFAAHLADSG--------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 LVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAE Rv2048c|M.tuberculosis_H37Rv LVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLE MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------AVMEDQVAVRGSTSYVPRLVHRDTLPSGKPLHLRADA MSMEG_0408|M.smegmatis_MC2_155 ---------------GEDQIALRGDAVYAPRLVRRTGEPSDTPLPVREDR Mvan_1003|M.vanbaalenii_PYR-1 ---------------SEDQIAVRGREIHVARLTRCAEKANAAALELRREA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 LATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGSWAAG Rv2048c|M.tuberculosis_H37Rv LATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGSWAAG MMAR_0101|M.marinum_M -----------------------------------------WVTYRCRAD MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu ----------------------------------RGPFLRTGDYGFLLDG Mflv_0405|M.gilvum_PYR-GCK TYLVTGGLGSLGLEIAGYLAANGAGHLVLTSRRTPDEAAASRIEALRERH MSMEG_0408|M.smegmatis_MC2_155 TYLVTGGLGAIGLEVAGYLASHGAGHVVLTSRREPGDDARRRLDGLREQY Mvan_1003|M.vanbaalenii_PYR-1 TYLVTGGLGALGLEVAEFLASHGAGHLVLTGRRSASDTVRQRIDAMRERF MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 TVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAA Rv2048c|M.tuberculosis_H37Rv TVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAA MMAR_0101|M.marinum_M DIEIVGGININPREIEQLIVEDHLVAETAVVAVREATG------------ MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu ELFVTGRLKDLIIIRGRNYHPNDIEATVQEVHPALMSGRGAAFAVSPDPS Mflv_0405|M.gilvum_PYR-GCK GCEVRVVTADVADAHAVARLLATVQAEMPPLAGIVHAAGEIGTTPLADLD MSMEG_0408|M.smegmatis_MC2_155 ACDVRVITADVADAHDVARLMTTVAAELPPLAGIVHAAGEIGTTPLSGLD Mvan_1003|M.vanbaalenii_PYR-1 DCQVLVATADVADRDDVARLFSTMRSELPPLAGIVHAAGEIGTSPLRTLD MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 AGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLT Rv2048c|M.tuberculosis_H37Rv AGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLT MMAR_0101|M.marinum_M -------------ESALQAFLVPESGASLGESAIKELHRRLLGSLSPHKV MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu GTEQLVIVQEVDRGRLGEVDTDELIAAIR---TAVTSQHDIGVHTVVLVD Mflv_0405|M.gilvum_PYR-GCK DAEVDRVFAGKVWGAWHLSEATSDLQ--LDFFISTSSIASVWGGFGQAAY MSMEG_0408|M.smegmatis_MC2_155 DAEVDRVFAGKVWGAWHLSEALTDLRTDLDFFVSTSSIASVWGGFGQTAY Mvan_1003|M.vanbaalenii_PYR-1 DAEMDRVFAGKVWGAVYLCEEVADMG--LDFFLATSSIASVWGSHGQTAY MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 PDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAA Rv2048c|M.tuberculosis_H37Rv PDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAA MMAR_0101|M.marinum_M PHRFEIAERLPRTASGKLQRGQ---------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu PLRIPTTSSGKIR------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GAANAFLDGLAWRLREQGVAGVSVNFGPWSAGMADAQSRARLEQRGIKTL MSMEG_0408|M.smegmatis_MC2_155 GAANAFLDGLAWRLRERGVTAVSVNFGPWAAGMADAESRARLEQRGVRTL Mvan_1003|M.vanbaalenii_PYR-1 GAANAFLDGLADSLRARGIPGISVNFGPWAAGMADAKAREQLSRRGVKTL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTSGLDAADLARLGREGV Rv2048c|M.tuberculosis_H37Rv ANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGV MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SPADALAGLSDAVISAAPHPVVARVDWSRFLPLYQQAGRRGFLAELEREL MSMEG_0408|M.smegmatis_MC2_155 SPAEALAGMADVVAGPVQG-VVAKIDWSRFLPLYQQAGRRAFLSELESEL Mvan_1003|M.vanbaalenii_PYR-1 APADALAGMADVIAASTAHAVVARIDWATFLPVYQLQRRRAFLSQLEREV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 LALSTAEALELFDTAMIVDEPFLAPARIDLTALRAHAVAVPPMFSDLASA Rv2048c|M.tuberculosis_H37Rv LALSTAEALELFDTAMIVDEPFLAPARIDLTALRAHAVAVPPMFSDLASA MMAR_0101|M.marinum_M -------------------------LRTQPAAQPVWERRCTVGTSDSDGQ MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu ---------------------------RRTCRQRFLDGELDAFAEWRLAT Mflv_0405|M.gilvum_PYR-GCK PAAPAQQGPAVTASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAEVTR-V MSMEG_0408|M.smegmatis_MC2_155 PAAATGAAAPATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAEVTR-V Mvan_1003|M.vanbaalenii_PYR-1 PDVPDASAPAP--SGTTRFVEELTLAPVEQRRKLVLEYLRAAVAEVTR-V MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 PTRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNI Rv2048c|M.tuberculosis_H37Rv PTRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNI MMAR_0101|M.marinum_M RDPQTQTNYKVGPRVGPVTLDERLAVLQQEGHRLIADTVSAEVAQILGDP MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu PRPAQPVPAADEQADEQAGAGPGAGPGADEIRAWFVAQLAGELG-----L Mflv_0405|M.gilvum_PYR-GCK DAAEIREDAGFFDLGMDSLMAVELRRRIETGVGKEIPVTLVMDHPRLSDA MSMEG_0408|M.smegmatis_MC2_155 DADEIRDEAGFFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPRLSDA Mvan_1003|M.vanbaalenii_PYR-1 DAAEIRDEAGFFDLGMDSLMAIELRRRLEQGLGKELPVTLAMDHPHLSDA MLBr_00135|M.leprae_Br4923 -----------------------------------MTASVEGADQKSEKL MUL_2005|M.ulcerans_Agy99 -----------------------------------MTTSGESADQQNDKL MAV_3108|M.avium_104 -----------------------------------MPG--------TEQH Mb2074c|M.bovis_AF2122/97 TPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRL Rv2048c|M.tuberculosis_H37Rv TPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRL MMAR_0101|M.marinum_M AAERIDRDVAFAELGFDSRMTVELRNRLAAVTGLRLPETVGWDYGSISRL MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu SPDDIDTGQPFAYYGLDSVRAIQLMTALEAWSGIKVAPTLAYDHPTIDLA Mflv_0405|M.gilvum_PYR-GCK ADYLLGDVLGLTEAATAP---------KAATVVSTAADEPIAIVAVSCRF MSMEG_0408|M.smegmatis_MC2_155 ADYLLVEVLGLGEQTNVR---------QASTVT-ARTDDPIAVVAVSCRF Mvan_1003|M.vanbaalenii_PYR-1 AEYVLGDVLGLSEHT-VA---------QPDTPSTVRTDDPIAIVGMACRF MLBr_00135|M.leprae_Br4923 ISYLKKVVVELDETR------------ARLREYEQRATEPVAVVGIGCRF MUL_2005|M.ulcerans_Agy99 FRYLKKVAVELDEAR------------ARLREYEQRATEPVAVVGIGCRF MAV_3108|M.avium_104 LDYLKRLTADLRRTR------------RRVAELEGRLSEPVAVVGMACRY Mb2074c|M.bovis_AF2122/97 ASYIRTELAGLPQEI------------KHTPAVRTTSEDPIAIVGMACRY Rv2048c|M.tuberculosis_H37Rv ASYIRTELAGLPQEI------------KHTPAVRTTSEDPIAIVGMACRY MMAR_0101|M.marinum_M AAHLETELAGSGGRG------------KPGPSVAGG--APVAIVGVGCRY MAB_3575c|M.abscessus_ATCC_199 --------------------------------------MEIDVTGIACRF TH_4458|M.thermoresistible__bu AEHLAGLTHTATSTAADAGVSTGAGRRPEHGPAPDRADEPIAIIGIGCRF : : .:.**: Mflv_0405|M.gilvum_PYR-GCK PG-APNPEAFWDLLSGGVDAIREVPEDR-FDIDEFYDPDPDAAGKTYTRY MSMEG_0408|M.smegmatis_MC2_155 PG-APDPESFWELLAGGVDAIREVPEDR-WDIDEFYDPDPDTPGKTYTRF Mvan_1003|M.vanbaalenii_PYR-1 PG-ADDTDAFWSVLAEGADLIREIPDDR-FDINEFYDPDPEAAGKIYSRY MLBr_00135|M.leprae_Br4923 PGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTYTRW MUL_2005|M.ulcerans_Agy99 PGGADGPEGLWDLVSQGRDAVTEFPNDRGWDTEGLFDPDPDAEGKTYTRW MAV_3108|M.avium_104 AGGVDSPEALWDLVIEGRDTVSDFPVDRGWDVEGLYDPDPDAKGKMYTRQ Mb2074c|M.bovis_AF2122/97 PGGVNSPDDMWDMLIQGRDVLSEFPADRGWDLAGLYNPDPDAAGACYTRT Rv2048c|M.tuberculosis_H37Rv PGGVNSPDDMWDMLIQGRDVLSEFPADRGWDLAGLYNPDPDAAGACYTRT MMAR_0101|M.marinum_M PGGVESAGGLWDVVVGGRDVISGFPVDRGWDVEGVFDPDPDALGKTYCRL MAB_3575c|M.abscessus_ATCC_199 PG-ADGVEAFWDMLLRGRNGTRVVPEDRWWADDFVSPAPPYGTGKVNTRH TH_4458|M.thermoresistible__bu PG-ADGPAAYWRLLREGRDAITATPPER-WDTDSVGDG---------TRW .* . . * :: : * :* : . * Mflv_0405|M.gilvum_PYR-GCK GGFLDHIDEFDPEFFGLSPREAVWIEPQQRLMLETVWEGLERAGYAPSAL MSMEG_0408|M.smegmatis_MC2_155 GGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYAPSDL Mvan_1003|M.vanbaalenii_PYR-1 GGFLDGVDGFDPEFFGISPREAVWIDPQQRLVLETAWEGLERAGYSAAAL MLBr_00135|M.leprae_Br4923 GAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDPLSL MUL_2005|M.ulcerans_Agy99 GAFVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSWEALEHAGIDPMSL MAV_3108|M.avium_104 GSFLQHAGDFDAGFFGIGPSEALAMDPQQRIMLEICWEALERAGIDPSAL Mb2074c|M.bovis_AF2122/97 GGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWEALERAGIDPTGL Rv2048c|M.tuberculosis_H37Rv GGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLELSWEALERAGIDPTGL MMAR_0101|M.marinum_M GGFLDGADRFDAGFFGIGPSEALAMDPQQRLLLECSWEALEDAGIDPVSL MAB_3575c|M.abscessus_ATCC_199 GAFIDDPERFDHGFFGIAPSEAAATDIQQRLVLQAGYHALEDAGIDPQSL TH_4458|M.thermoresistible__bu GGFLERIDGFDAGFFGISPREAVRIDPQQRLLLEVAWEALEDAGLVPDRL *.*:: ** ***: * *. : *:*::*: :..** ** . * Mflv_0405|M.gilvum_PYR-GCK RGSRTGVFVGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALG MSMEG_0408|M.smegmatis_MC2_155 RGSRTGVFTGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALG Mvan_1003|M.vanbaalenii_PYR-1 RGSRSGVYVGVGANEYSHLLSGGSLDGIEAQFITGNALNVIAGRVSFTLG MLBr_00135|M.leprae_Br4923 RGSATGVFTGIFAPSYGS----RDTGGLQGYGLTGTAVSVASGRVSYVLG MUL_2005|M.ulcerans_Agy99 RGSSTGVFTGIFAPSYGG----KDVGALQGYGLTGSPVSVASGRVAYVLG MAV_3108|M.avium_104 RGTATGVFAGVIHAGYGG----EVKGELEGYGLTGSTLSVTSGRVSYVLG Mb2074c|M.bovis_AF2122/97 RGSATGVFAGVMTQGYGM----FAAEPVEGFRLTGQLSSVASGRVAYVLG Rv2048c|M.tuberculosis_H37Rv RGSATGVFAGVMTQGYGM----FAAEPVEGFRLTGQLSSVASGRVAYVLG MMAR_0101|M.marinum_M RGSVTGVFTGLMSSDYGAG---RVSGDLEGYGLTSAAASVASGRVAYLLG MAB_3575c|M.abscessus_ATCC_199 RGSTTGVFVGVMSSDWGALHL-TDYAGMTPQRGVGNGYCMLANRVSYALD TH_4458|M.thermoresistible__bu AGSRTGVFTGVSTYDYLHLQ-LSHPELIDAYSGTGTASSIAANRLSYVFD *: :**:.*: : : .. :.*::: :. Mflv_0405|M.gilvum_PYR-GCK LEGPAVAVDTACSSSLVAVHQATQALRSGDCDMALAGGVNVLLSPVTVVA MSMEG_0408|M.smegmatis_MC2_155 FEGPAVAVDTACSSALVAVHQACQALQSGDCDLALAGGVNVLLSPVTVVA Mvan_1003|M.vanbaalenii_PYR-1 LEGPAVAVDTACSSSLVAVHQACQGLQSGDCDLALAGGVNVLLSPATTIA MLBr_00135|M.leprae_Br4923 LEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVG MUL_2005|M.ulcerans_Agy99 LEGPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMGLPSIFVG MAV_3108|M.avium_104 LEGPAVSVDTACSSSLVAMHLAAQSLRSGECDLALAGGVTVMATPAAFVE Mb2074c|M.bovis_AF2122/97 LEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVE Rv2048c|M.tuberculosis_H37Rv LEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVE MMAR_0101|M.marinum_M LEGPAVSVDTACSSSLVALHLAASSLRSGECDVALAGGVTVMATPATFVG MAB_3575c|M.abscessus_ATCC_199 LTGPSMSVDTACSSSLTAVHLAAGALRAGECDLAIVAGVNLMLTPILSIF TH_4458|M.thermoresistible__bu FRGPSLTLDSACSSSLVAVHQACRSLRDGECDLALAGGVNIMLSAGIGLN : **::::*:****:*.*:* * .*: *:**:*:..**.: . : Mflv_0405|M.gilvum_PYR-GCK ASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAVRDGDRVCAV MSMEG_0408|M.smegmatis_MC2_155 ASRARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAV Mvan_1003|M.vanbaalenii_PYR-1 TSRARMLSPDGRCKTFDAAADGYVRGEGCGILVLKRLSDAVRDGDRIQAV MLBr_00135|M.leprae_Br4923 FSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGHTVLAV MUL_2005|M.ulcerans_Agy99 FSRQRGLAADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRNGHNVLAV MAV_3108|M.avium_104 FSRQRALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPVWAV Mb2074c|M.bovis_AF2122/97 FSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAV Rv2048c|M.tuberculosis_H37Rv FSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAV MMAR_0101|M.marinum_M FSRQRGLAADGRCKAFAGAADGTGFSEGAGVVVLMRLSEARRRGLAVLGV MAB_3575c|M.abscessus_ATCC_199 YTQAGLSAPDGRCRPFAKSGGGIGRGEGVGAVVLRRSEDRPDDAPAPYAT TH_4458|M.thermoresistible__bu FTRAGVMATDGRCKTFDARADGWVRGEGAGIVVLKPLREALADEDPIYAV :: :. ***: : ..* .** * :** : .. Mflv_0405|M.gilvum_PYR-GCK IAGSAVNQDGASSGLTVPNGGAQQRLIGTVLARAGITGGEVDYLEAHGTG MSMEG_0408|M.smegmatis_MC2_155 IPASSVNQDGASSGLTVPNGGAQQRLIEATLARAGLSGADVDYLEAHGTG Mvan_1003|M.vanbaalenii_PYR-1 IRGSAVNQDGASGGLTVPNGGAQQRVIAAALTRAGLSGSDIDYLEAHGTG MLBr_00135|M.leprae_Br4923 VRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDVVEAHGTA MUL_2005|M.ulcerans_Agy99 VRGSAINQDGASNGLTAPNGLTQQRVIQAALANCGLTSADVDVVEAHGTA MAV_3108|M.avium_104 LRGSAVNQDGASNGLTAPNGPSQQRVIRAALANAGLSAVDVDVVEGHGTG Mb2074c|M.bovis_AF2122/97 VVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTG Rv2048c|M.tuberculosis_H37Rv VVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTG MMAR_0101|M.marinum_M IAGSAVNQDGASNGLTAPNGPAQQRVIEAALANAGLTAADVDVVEGHGTG MAB_3575c|M.abscessus_ATCC_199 VRGSFVGQDGRSNGITAPTRRGQERVIAAALRSAGHTGADLHFVEAHGTG TH_4458|M.thermoresistible__bu IRGSAVNQDGRTNGLMAPSRTAQEVVLTDAYRRAGVSPGVVQYVEAQGIG : .* :.*** :.*: .*. *: :: . .* : :. :*.:* . Mflv_0405|M.gilvum_PYR-GCK TPLGDPIEVQAAAAAYAGAR-DADRPLLMGSVKTNIGHTESASGAAGLIK MSMEG_0408|M.smegmatis_MC2_155 TPLGDPIEVQAAAAAYGAGR-DADRPLLMGSVKTNIGHTESASGAAGLIK Mvan_1003|M.vanbaalenii_PYR-1 TSLGDPIEVQAAGAVLGAGR-DPDRPLLMGSVKTNVGHLESASGVAGLIK MLBr_00135|M.leprae_Br4923 TTLGDPIEAQALLATYGQGR-PADQPLWVGSIKSNMGHTQAAAGVAGVIK MUL_2005|M.ulcerans_Agy99 TTLGDPIEAEALLATYGQGR-PTDQPLWVGSIKSNMGHTQAAAGVAGVIK MAV_3108|M.avium_104 TVLGDPIEAQALLATYGQDR-PADRPLWLGSIKSNIGHTSAAAGVAGVIK Mb2074c|M.bovis_AF2122/97 TTLGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIK Rv2048c|M.tuberculosis_H37Rv TTLGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIK MMAR_0101|M.marinum_M TTLGDPIEAQALLATYGQAR-PADQPLWLGSIKSNMGHTQAAAGIAGVIK MAB_3575c|M.abscessus_ATCC_199 TTLGDLIETQALGATCGDRV--GRAPLVVGSVKGNIGHTEGAAGIAGFIK TH_4458|M.thermoresistible__bu TPVGDAIEVGALGTVLAEDR-PPDSPCLIGSVKTNIGHLEAAAGIAGLIK * :** **. * :. . * :**:* *:** ..*:* **.** Mflv_0405|M.gilvum_PYR-GCK VVLSLQHETLPQSLHFDTPSPHIPWDSLPVRVVDTAMPWQPN-GRPRRAG MSMEG_0408|M.smegmatis_MC2_155 VVLSLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQTN-GRVRRAG Mvan_1003|M.vanbaalenii_PYR-1 VVLSLQHEMLPRHLHFKTPSPHIPWDRLAVRVVAEPTPWRAD-GRPRRAG MLBr_00135|M.leprae_Br4923 MVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSVE-GRPRRAG MUL_2005|M.ulcerans_Agy99 MVQAMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDWPDA-GRPRRAG MAV_3108|M.avium_104 MVQALRHGVMPKTMHVDVPSPHVDWSAGAVSLLTDPRPWPEH-GGPRRAG Mb2074c|M.bovis_AF2122/97 MVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAG-ARTRRAG Rv2048c|M.tuberculosis_H37Rv MVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAG-ARTRRAG MMAR_0101|M.marinum_M MVQAMRHELMPATLHVDVPSPHVDWSSGAVSLLTQPRPWPAVDGRPRRAG MAB_3575c|M.abscessus_ATCC_199 ACLSMHHRTVPPSLFADDENPALDLAERNLKLAVSAEKLPRG---DLLAG TH_4458|M.thermoresistible__bu VALALRHRMIPPTLNFTEPNPTIEFDKLPVRVAQTLTPWPDD-SGRAVAG :::* :* : . : : : ** Mflv_0405|M.gilvum_PYR-GCK VSSFGFTGTNAHVLIEEAPTDLAGPTEPTAPAEPVDEDAAADP-APAPVE MSMEG_0408|M.smegmatis_MC2_155 VSSFGFTGTNAHVLVEEAPPQLH-----TADAAPVEPAATAEAGTDDSPQ Mvan_1003|M.vanbaalenii_PYR-1 VSSFGFSGTNAHVVLEEPPAQSADLRQPPTDGK-DGAAGLESATAPEPAG MLBr_00135|M.leprae_Br4923 VSSFGISGTNAHVILEEAPTPVE-----------ASYSTAD--QQRLSVV MUL_2005|M.ulcerans_Agy99 VSSFGISGTNAHVILEEAPAPEA-----------VPDSESNKGEPSLPVV MAV_3108|M.avium_104 VSSFGISGTNAHVIVEQAPAAAE-----------TEAAPAS-STMPDAVV Mb2074c|M.bovis_AF2122/97 VSSFGISGTNAHVIIEAVPVVPR-----------REAGWAG------PVV Rv2048c|M.tuberculosis_H37Rv VSSFGISGTNAHVIIEAVPVVPR-----------REAGWAG------PVV MMAR_0101|M.marinum_M VSSFGISGTNAHVIVEQVCPEVV-----------AEAVDVS-----PDSL MAB_3575c|M.abscessus_ATCC_199 VSSFGLGGTNVHVVIGSAPRVRR-----------PIRRGG--------IG TH_4458|M.thermoresistible__bu VSAFGFGGTNAHVVLAEAPQVRA--------------AATADDHADGFVE **:**: ***.**:: Mflv_0405|M.gilvum_PYR-GCK VLPLSARSPEALVALAQRYETWLTAHPEADLADVCRTAGTGRSHFEHRAA MSMEG_0408|M.smegmatis_MC2_155 VLALSARSPEALVELARRYDDWLSATPGLDIADVCHTAGVGRSHFEYRAA Mvan_1003|M.vanbaalenii_PYR-1 VLPISARSPEALTALARRYESWLTAHPDADIADVCYTAGAGRSHFEHRAA MLBr_00135|M.leprae_Br4923 PWVVSGRSTAALMAQASRLAFYVQADPEVDPVDVGCALAA-RSVFEHRAV MUL_2005|M.ulcerans_Agy99 PWVISARSAEALTAQAGRLLAHVQADPQSNPVDIGFSLAG-RSAFEHRAV MAV_3108|M.avium_104 PWVVSARSAEALAGQARRLLDHVTADAQASPLDVGWSLVSTRAVFEHRAV Mb2074c|M.bovis_AF2122/97 PWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAV Rv2048c|M.tuberculosis_H37Rv PWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAV MMAR_0101|M.marinum_M PWVVSGKSEAAVAAQAKRLLAAVQADEGLDRLDVGFSLAR-RTAFEYRAV MAB_3575c|M.abscessus_ATCC_199 VLTVSGNDAAALRRNLDRLVAGFDPTEHWP--RYCYSTNQVKAGGTQRIA TH_4458|M.thermoresistible__bu ILPLSARSQAALDALAERYESALTG--GVPPADLCHTAGARRAHHDHRLA :*... *: * . : :: * . Mflv_0405|M.gilvum_PYR-GCK LVVDSVESARIALTDLAQNRLRPGVVRG--EHLNHPTTAWMFTGQGSQYP MSMEG_0408|M.smegmatis_MC2_155 LVVDSVERAREGLAALAEGRTPAGVVRG--EHVHRPTTAWLFTGQGSQYP Mvan_1003|M.vanbaalenii_PYR-1 LVVDSVDGARDLLAGLAEDRLGPGAVRG--VCGDPPKTAWLFTGQGSQYP MLBr_00135|M.leprae_Br4923 VVGESREQLIAGLAGLAVGESGAGVAIG--QAAPLGKTVVVFPGQGAQRI MUL_2005|M.ulcerans_Agy99 VVGADRQQLLTGLATLADGAPGAGVVTG--QAGSVGKTAVVFPGQGSQRI MAV_3108|M.avium_104 VVGRERGALATGLAGLASGRPGPATVVG--RARSTGKTVLVFPGQGSQTL Mb2074c|M.bovis_AF2122/97 VVGGDRDRLLAGLDELAGDQLGGSVVRG--TATAAGKTVFVFPGQGSQWL Rv2048c|M.tuberculosis_H37Rv VVGGDRDRLLAGLDELAGDQLGGSVVRG--TATAAGKTVFVFPGQGSQWL MMAR_0101|M.marinum_M VLGEDRQQLISGLTELAAGQPGPTVLNG--RAATVSKTVMVFPGQGSQRL MAB_3575c|M.abscessus_ATCC_199 LVTRDG-ADLAGEAEVALHRLARRNERA--RRRRP-RIAFVYTGQGSQYR TH_4458|M.thermoresistible__bu VVGASRAELIGALAAYRRGEPHPGVFTGRSQSGHRSGVVFVFSDEGSQWR :: . . . ::..:*:* Mflv_0405|M.gilvum_PYR-GCK GMARELFDTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVPPTET MSMEG_0408|M.smegmatis_MC2_155 GMARELFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRET----ADL Mvan_1003|M.vanbaalenii_PYR-1 GMARELFDTEPVFRDTVTRCAEAIGDTLPRPLLEVLFDTDGDN----GQT MLBr_00135|M.leprae_Br4923 GMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGADAGL------- MUL_2005|M.ulcerans_Agy99 GMARELHDQLPVFAEAFDAVADELDRHLRIPLCEVMWGSDVAL------- MAV_3108|M.avium_104 GMGRQLYERFEVFAGALDEAVAVVDEHSRLSVREVMWGADPEL------- Mb2074c|M.bovis_AF2122/97 GMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGHDENL------- Rv2048c|M.tuberculosis_H37Rv GMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGHDENL------- MMAR_0101|M.marinum_M GMGQQLHGQFPVFAQAFDAVVEQLDRYLRLPLRDALWGGDEHL------- MAB_3575c|M.abscessus_ATCC_199 EMGLALREQHSGFAEALAEADALLEPHFGGSVVRAIETGEDHLG----RS TH_4458|M.thermoresistible__bu GMAQRLYAEDQVFRTALAECDRALRRHMEISPLSELLADPSHSR------ *. * * . : . : Mflv_0405|M.gilvum_PYR-GCK LRHTSFAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVAGVFS MSMEG_0408|M.smegmatis_MC2_155 LQHTSFAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFS Mvan_1003|M.vanbaalenii_PYR-1 LRHTSYAQPALFAIEMGLARLWQARGIEPDVVLGHSVGQYAAACVAGVFG MLBr_00135|M.leprae_Br4923 LDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLA MUL_2005|M.ulcerans_Agy99 LDSTEFAQAALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVAGVLT MAV_3108|M.avium_104 LQSTEFAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAAACVAGVLS Mb2074c|M.bovis_AF2122/97 LNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLS Rv2048c|M.tuberculosis_H37Rv LNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLS MMAR_0101|M.marinum_M LESTEFAQPSLFAVEVALFALLRDWGVSPDVVMGHSVGELSAAHVAGVLT MAB_3575c|M.abscessus_ATCC_199 LDDTVVAQPALFALQYALTTTFAAHGVRPDVVLGHSVGEIAACAAAGVLD TH_4458|M.thermoresistible__bu MDEVTIASPALFAVQVALAALWQSWGVEPAAVIGHRMGEVAAAHVAGVLG : . *..:**..: .* .: * *:** :*: :*. .***: Mflv_0405|M.gilvum_PYR-GCK LEDGARLMAERGRLFGSLPEGGRMVAVFADAKRVEQVAADFPRVSVGAYN MSMEG_0408|M.smegmatis_MC2_155 LDDGARLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEFPRVSVGAYN Mvan_1003|M.vanbaalenii_PYR-1 LEDGARLVADRGRLFGGLPVGGRMVAVFTDAEVVEDFADEFPQVSVAAYN MLBr_00135|M.leprae_Br4923 PADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEG--VGIAAIN MUL_2005|M.ulcerans_Agy99 LVDAAMLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDG--VGIAAIN MAV_3108|M.avium_104 LRDAARLVAARGALMAALPPGGVMVAVTAGESQVGPLLGGG--VSIAAVN Mb2074c|M.bovis_AF2122/97 LENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAE--VDIAAVN Rv2048c|M.tuberculosis_H37Rv LENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAE--VDIAAVN MMAR_0101|M.marinum_M LDDAAKLVAARGRLMQALPEGGAMFAIAASEHEVSPLLGEA--VGIAAIN MAB_3575c|M.abscessus_ATCC_199 PAAAAALVVTRGALMGALPAGGTMLAARLPAELADEFVSGP--VALAAVN TH_4458|M.thermoresistible__bu LDDAAALLCGRTRLSRLASTG----------------------------- .* *: * : . * Mflv_0405|M.gilvum_PYR-GCK GPN-TVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVLDEFE MSMEG_0408|M.smegmatis_MC2_155 GPN-TVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLDEFE Mvan_1003|M.vanbaalenii_PYR-1 GPN-TVLAGPASDLEQIVAGCSGEGIRTTWLDTSHAFHSALLDPVLDEFE MLBr_00135|M.leprae_Br4923 APESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFV MUL_2005|M.ulcerans_Agy99 APKSVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPMLEEFA MAV_3108|M.avium_104 GPDAVVLSGEQEAVAAVADRLAGSGARVHRLAVSHAFHSALMEPMLDGFA Mb2074c|M.bovis_AF2122/97 GPASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFA Rv2048c|M.tuberculosis_H37Rv GPASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFA MMAR_0101|M.marinum_M APDAVVISGERAAVGVLAEELIDRGRRVHRLAVSHAFHSPLMEPMLADFA MAB_3575c|M.abscessus_ATCC_199 GPDSVTFSGPVERIAEVADQLNGRGVHTRELVVSHAFHSPAMEPVGGELA TH_4458|M.thermoresistible__bu -------------------------------------------AVREGLD .: : Mflv_0405|M.gilvum_PYR-GCK SYAAQLQFAAPTLPLVCNRTGAVLTGQT-SLDAQYWRRHSRQPVQFAESV MSMEG_0408|M.smegmatis_MC2_155 AYAAQFQFAAPTLPLVCNRTGAVLTGQT-PLDAQYWRRHSRQPVQFAESV Mvan_1003|M.vanbaalenii_PYR-1 SCAARLAYAAPTRPLVCNRTGAVVTGPG-VIDAQYWRRHARQPVQFAESV MLBr_00135|M.leprae_Br4923 RVAAQVEVRKPQIGLVSNVTGELAGPD--FGSPQYWGEHVSRAVRFVDSA MUL_2005|M.ulcerans_Agy99 RIAAQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAVRFADSA MAV_3108|M.avium_104 AAAAGIEPRPPRIPLVSNLTGQLAGPG--YGTPQYWVDHVRRPVRFVDGV Mb2074c|M.bovis_AF2122/97 AVAAGIAIGRPTIGVISNVTGQLAGDD--FGSAAYWRRHIRQAVRFADSV Rv2048c|M.tuberculosis_H37Rv AVAAGIAIGRPTIGVISNVTGQLAGDD--FGSAAYWRRHIRQAVRFADSV MMAR_0101|M.marinum_M LAAGDITAHPPRIALVSNLTGELAGPD--YGSAQYWVEHVRRPVRFADSV MAB_3575c|M.abscessus_ATCC_199 AAAPLPAESAGAPIVISSVTGTAAEAAD--FTGDYWRAQLLGTVDFLGAA TH_4458|M.thermoresistible__bu GLLANLRPDDPRIPLYSTVTGDAVTGRG--FGAAHWMENLHSPVRFSAAV : .. ** :* : .* * .. Mflv_0405|M.gilvum_PYR-GCK RTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAAPRAIASLRKGVADRRQ MSMEG_0408|M.smegmatis_MC2_155 RTVAALGCSVLMEIGPQPVLTGAAVQVWPEHMAAPRAVASLRKGVADRRQ Mvan_1003|M.vanbaalenii_PYR-1 RTLADLGCSVLMEIGPQPFLIAAALRVWPESAATPRAIPSLRKGPDARRQ MLBr_00135|M.leprae_Br4923 RHLQTLGATHFIESGPSSGLMGAIEQSLAPAEAV--VVSMMGKDRPELAS MUL_2005|M.ulcerans_Agy99 RQLHTLGVTHFVEVGPGSGLTGSIEQSLAPAEAV--VVSMLGKDRPEVAS MAV_3108|M.avium_104 RLAESQGAGVFLEVGPGAALTSAVEQSLTSDRAM--SVVTMPKGRPEVDS Mb2074c|M.bovis_AF2122/97 RFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVT--TMSALRKDRPEPAT Rv2048c|M.tuberculosis_H37Rv RFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVT--TMSALRKDRPEPAT MMAR_0101|M.marinum_M RNLEELGASHFIEVGPGGGLSSAIAQSLRSPEAV--TVPVLGKDRPEVNS MAB_3575c|M.abscessus_ATCC_199 RTLADMEPSHIIEIGPRSTLLSLLAAADLIPDSQ--RIAPVPGAAATGLD TH_4458|M.thermoresistible__bu RRLLGRGHDAFLEISAHPMLLSAVQEDAADLGRSCTTLVSMRRGECGRDV * ::* .. * . : : Mflv_0405|M.gilvum_PYR-GCK IADALAAAYIGGHKPDFAALHEQ-RGVRLELPTYPFQRRRFWPK----SA MSMEG_0408|M.smegmatis_MC2_155 IADALASAYVGGHRPDFAAVHRQ-PRRPVELPTYPFQRRRFWPK----AS Mvan_1003|M.vanbaalenii_PYR-1 LAEAVAAAYIAGHRLDFTGHDGG-PHRRLPLPTYPFQHRSYWPK----TA MLBr_00135|M.leprae_Br4923 VLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPGTDGT MUL_2005|M.ulcerans_Agy99 VLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRRFWEVPGADGP MAV_3108|M.avium_104 LLTAAARLFTAGADVRWSAAFTGLHARRVDLPTYAFARRRFWLSGDAVGS Mb2074c|M.bovis_AF2122/97 LTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRFWLS-GDGVA Rv2048c|M.tuberculosis_H37Rv LTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRFWLS-GDGVA MMAR_0101|M.marinum_M LISAVGQLFSTGVGVDWSAVFAGSGGRQVGLPTYAFARRRFWLD-GSASA MAB_3575c|M.abscessus_ATCC_199 FADALAALWQWGLDIDWRPLYAEHDRVVGRLPGYVFAD------------ TH_4458|M.thermoresistible__bu LMTSLAALYASGHAVDWARVHPH-GSHCTAAPTYPWQRQRFWLDIDRCDT . : . : * : * * : Mflv_0405|M.gilvum_PYR-GCK GMAIDGRVGASAGSGILGSGKDLASGDSVYTSRLSVKTQPWLSDHVIYGT MSMEG_0408|M.smegmatis_MC2_155 SIAVDG---GTAASGILGSGKDLASGDTIYTSRLSVKSQPWLADHVIYGT Mvan_1003|M.vanbaalenii_PYR-1 GIRSDG----SSGSGLLGSAQDLASGDIVHTSRLSVKTQPWLSDHVIYGT MLBr_00135|M.leprae_Br4923 ASVSGLGLGSTEHALLGAVVERPDSGGVVLTGRLSLANQPWLADHVIGGV MUL_2005|M.ulcerans_Agy99 ADATGLGLGGAEHALLGAVVERPDSGGVVLTGRLALADQPWLADHVIGGV MAV_3108|M.avium_104 ANIASLGLAEAEHPLLGAVLDRPDSGGVVLTGRLSTAAQPWLADHAVAGT Mb2074c|M.bovis_AF2122/97 ADAASLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGV Rv2048c|M.tuberculosis_H37Rv ADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGV MMAR_0101|M.marinum_M ADVGEAGLVAAGHALLGAVVEQPDTGAVVLTGRLSLARQPWLADHLVGGA MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu GDGAGTG------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VVVPGATYAAMALAAVGTP--AHAKDVFFYEPIILPEKSSREVQLTVHPS MSMEG_0408|M.smegmatis_MC2_155 VVVPGATYAAMALAAVGTP--ARLKDVFFYEPIILPEKASREVQLTLHPA Mvan_1003|M.vanbaalenii_PYR-1 VVVPGATYAAMALAAMPTP--ARVQEVFFYEPIILGDKDSREVQLMLHRT MLBr_00135|M.leprae_Br4923 VLFPGAGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVVAAA MUL_2005|M.ulcerans_Agy99 VLFPGAGFVELAIRAGDEVGCAVVEELVLAAPLVLHPGMGVQVQVIVGTA MAV_3108|M.avium_104 VLFPGAGFVELALRAGDEVGCPVVEELTLSAPLSLPAGGTVQLQVVVADA Mb2074c|M.bovis_AF2122/97 TIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP Rv2048c|M.tuberculosis_H37Rv TIFPGAGFVELAIRAGDEVGCGVVDESTLAAPLVLPASGSVAVQVVVNGP MMAR_0101|M.marinum_M VLFPGTGFVELAIRAGDEVGCGVVEELTLATPLVLNAGTAVQVQVVVGSA MAB_3575c|M.abscessus_ATCC_199 ------------------------EERFFASAATVGP------------- TH_4458|M.thermoresistible__bu ---------------------GTAERTVVPAPLPAPSASAAPTVDEVLLC . . . Mflv_0405|M.gilvum_PYR-GCK VDGESK-FQVHSRPYGERGAEWALNAEGVVASGVGDSPAAAGDLEDPVDE MSMEG_0408|M.smegmatis_MC2_155 DGGSVLSFQIHSRPYGERGADWSLNAEGTVDTAGSDPDAAADEQSDPVDE Mvan_1003|M.vanbaalenii_PYR-1 DDADGWTFEVHSRPYGDRDADWSRNASGTVAAGVG--DAAPDAAADPVDN MLBr_00135|M.leprae_Br4923 D-ESSRRAVSVYSRGDQSHGGWLLNAEGLLE------VDAAEATVDLSLW MUL_2005|M.ulcerans_Agy99 D-DSGNRALSVYSRGDKSED-WLLNAEGMLG------VEAASSGADLSVW MAV_3108|M.avium_104 AGQPGSRSVAVYSR--VAQSEWTLHAEGVLS------EAAPAPAAELSVW Mb2074c|M.bovis_AF2122/97 D-ESGVRGVSVYSRGDVGTG-WVLHAEGALR------AGSAEPTADLAMW Rv2048c|M.tuberculosis_H37Rv D-ESGVRGVSVYSRGDVGTG-WVLHAEGALR------AGSAEPTADLAMW MMAR_0101|M.marinum_M G-QSGQRLVSMYSRADQPDQHWVLHAQGSVAPAAV--QPAAAASAELSTW MAB_3575c|M.abscessus_ATCC_199 ----------------------LVHTQSVRT--------ATAPVREVASV TH_4458|M.thermoresistible__bu ADQRERRELLESYLRDRVAAELGVLPP------------LLDVAAPLSTL . Mflv_0405|M.gilvum_PYR-GCK AIERLNRMRPQELFETFADLELAWGPTWSGSLKSLWLGEGEAIGDILVGA MSMEG_0408|M.smegmatis_MC2_155 VIERLERMRPQDLFETFADLELAWGPTWSGSLKSLWLGDGEAVGDILVGA Mvan_1003|M.vanbaalenii_PYR-1 AIERLTRTRPQQLFDAFADNDLAWGPAWCSSLRSLWVGTGEAVGDIAVGA MLBr_00135|M.leprae_Br4923 PPEGAESVDISDAYPQLAERGYAYGPAFQG-LVAIWRRGSELFAEVVAPT MUL_2005|M.ulcerans_Agy99 PPEGAESVDISDGYAQLADRGYAYGPGFQG-LVGVWRRDSELFAEVVAPS MAV_3108|M.avium_104 PPADAEAVDVAGGYDDLAGRGYGYGPAFRG-LRAVWRRGAETFAEVELPE Mb2074c|M.bovis_AF2122/97 PPAGAVPVEVADGYQQLAERGYGYGPAFRG-LTAMWRRGDEVFAEVALPA Rv2048c|M.tuberculosis_H37Rv PPAGAVPVEVADGYQQLAERGYGYGPAFRG-LTAMWRRGDEVFAEVALPA MMAR_0101|M.marinum_M PPAGAEAVDIGGLYERLARRGYGYGPAFQG-LRAVWRRGRDVFAEVGLPN MAB_3575c|M.abscessus_ATCC_199 PPADDESQPDVGVVHRAVIR------------------------------ TH_4458|M.thermoresistible__bu GIDSLTAAELRARVERDLGIVIPVAQLLNG-------------------- Mflv_0405|M.gilvum_PYR-GCK ELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLYLPLRYGQVS MSMEG_0408|M.smegmatis_MC2_155 ELAEQLGSEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVT Mvan_1003|M.vanbaalenii_PYR-1 ELGEHLGREPIHPVLLDLCTGIAGAALLAAAAQTDADPELFLPLRYGRVE MLBr_00135|M.leprae_Br4923 --GVVVDGMGMHPALLDAVLHALGLAIENTQ----ATTEMRLPFCWRGVS MUL_2005|M.ulcerans_Agy99 --GVAVDKMGMHPVVLDAVLHALGLTAEQNP----DSDETKLPFCWRGVS MAV_3108|M.avium_104 QAGVSTGRFGIHPVLLDAALHALGVADKR--------LETVLPFSWQGVS Mb2074c|M.bovis_AF2122/97 DAGVSVTGFGVHPVLLDAALHAVVLSAESAER---GQGSVLVPFSWQGVS Rv2048c|M.tuberculosis_H37Rv DAGVSVTGFGVHPVLLDAALHAVVLSAESAER---GQGSVLVPFSWQGVS MMAR_0101|M.marinum_M DEGLDLTDVGIHPALLDAVLHATMAAAGADV------AEMRLPFSWRGVS MAB_3575c|M.abscessus_ATCC_199 -------------VLADVGGH-------------------------REDA TH_4458|M.thermoresistible__bu ------------PSVSDLAEWISTTMVGFGST------------TPEPES : * Mflv_0405|M.gilvum_PYR-GCK LQEKMPRRFYCRATWHEAPLDSETQVFDLEYLDRDGRHLGGVREFTVKRA MSMEG_0408|M.smegmatis_MC2_155 LAEKMPRRFYCRARWHRSALDSETQVFELEFVDLGGRALGGIREFTVKRA Mvan_1003|M.vanbaalenii_PYR-1 VRERMPRRFYCRARWQTGGIDSETQVFDLDFLDHDGRNLGGIREFTVKRA MLBr_00135|M.leprae_Br4923 LHAGGAGRVRARFTSAGAD---AIAVDIADSAGLPVLTVRSLVTRAMTAE MUL_2005|M.ulcerans_Agy99 LHAGGAGRVRARLTMSGPD---SISVEIADAAGLPVLTVGALVTRAMSAA MAV_3108|M.avium_104 LHAAGASRVRVRLAPAGAG---AVSVELADASGVPVLSVRELVTRAVSAE Mb2074c|M.bovis_AF2122/97 LHAAGASAVRARIAPVGPS---AVSIELADGLGLPVLSVASMLARPVTDQ Rv2048c|M.tuberculosis_H37Rv LHAAGASAVRARIAPVGPS---AVSIELADGLGLPVLSVASMLARPVTDQ MMAR_0101|M.marinum_M LHAAGAAGLRARIAALDGGDGAAVSVELADAAGLPVLSVDSLVTRPVTAN MAB_3575c|M.abscessus_ATCC_199 LHAAADLRDDLGFDSVQAM---QFADRIVNELDMPRLDPVAIQDNLTTIA TH_4458|M.thermoresistible__bu AGVPGRSRPPDGAVASGSGDGGRWIELLNQMPEVSDDTVDELLRQLLAAG : : Mflv_0405|M.gilvum_PYR-GCK PREALLRGLGG-DATRLLYTLGWHEVPVPESGDGAAP-QGTWLIGGFDEL MSMEG_0408|M.smegmatis_MC2_155 PREALLRGLGG-DATRLLYTLGWHEVPPPPSADDAV---GTWLIAGFDEL Mvan_1003|M.vanbaalenii_PYR-1 PREALLRGLGA-DATRLIYRVGWRETSPPVRDDGALGPSSTWLVAGLDAL MLBr_00135|M.leprae_Br4923 QLRTAVTAAGG-ALEQGPMDLVWSPIPLSSDGHGG-GLPSVVSWADYCAG MUL_2005|M.ulcerans_Agy99 QLRAAVAEAGGGAPDQGPLDVIWSPIPLSGSGTNGSAQPAVVSWADFCAG MAV_3108|M.avium_104 QLAAAVAVRSG---SGELLDVAWSVIEPRNSLPDN--------------- Mb2074c|M.bovis_AF2122/97 QLRAAVSSSGP----DRLFEVTWSPQPSAAVEPLP-----VCAWG----- Rv2048c|M.tuberculosis_H37Rv QLRAAVSSSGP----DRLFEVTWSPQPSAAVEPLP-----VCAWG----- MMAR_0101|M.marinum_M QLNAAIAAAAG-APDDKLLEVAWSPIALNDRTIGGRDDVPVMLWDDHRDD MAB_3575c|M.abscessus_ATCC_199 DLTKLVAGTAG--------------------------------------- TH_4458|M.thermoresistible__bu ENHDDTQLH----------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AVSVPGCIPADR----------------TNPESLRQLLTDAHGRGLPFSG MSMEG_0408|M.smegmatis_MC2_155 AAKVPGCVPIDRN---------------TDLQVLGEVLSQAHARGAGFSG Mvan_1003|M.vanbaalenii_PYR-1 ADDVPGSIRIGFDRIWDPDRDGRVVLDPADDEHWRRLFALADERRAPVAG MLBr_00135|M.leprae_Br4923 --------------------------------------------RGNDTG MUL_2005|M.ulcerans_Agy99 GDGG----------------------------------------AAGDAG MAV_3108|M.avium_104 ---------------------------------------------PISEG Mb2074c|M.bovis_AF2122/97 --------------------------------------------TTEDSA Rv2048c|M.tuberculosis_H37Rv --------------------------------------------TTEDSA MMAR_0101|M.marinum_M D-------------------------------------------GHGAGT MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VVWRAARSDGDESD--AEVAARLEAEIAELLGAVHTVQGGEVKLPGGLWI MSMEG_0408|M.smegmatis_MC2_155 VVWRCATPGRKESGSASAESARLEAEITNLLSAVHAAQGPSVKLPGGLWI Mvan_1003|M.vanbaalenii_PYR-1 VVLGVTGRARPEEPS-ADFAARLEAQIRDVLGAVHSLSALGAKPAAGLWI MLBr_00135|M.leprae_Br4923 VVVWEFGSASAGAQAPVDSVAAVYSATHAALQVLQFWFGQ--DRAGTLVV MUL_2005|M.ulcerans_Agy99 VVVWEP------NPAGEDVVGPVYAATHAALEVLQSWFDG--DRAGTLVV MAV_3108|M.avium_104 VTVWEP------AAVDGAGPAAVHAATHQALGVLQSRLAG--EAGGVLVV Mb2074c|M.bovis_AF2122/97 AVVFES------VPLAGDVVAGVYAATSSVLDVLQSWLTR--DGAGVLVV Rv2048c|M.tuberculosis_H37Rv AVVFES------VPLAGDVVAGVYAATSSVLDVLQSWLTR--DGAGVLVV MMAR_0101|M.marinum_M VVIWES-----CCAADDDVVRSAYAATHAALAVLQSWLSG--DRPGTLVI MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VTERAVATESGEPVDPVQAALWGFGRTAINEEPALRCRLVDCDGSPQAVQ MSMEG_0408|M.smegmatis_MC2_155 VTEHGVACESGEPVDPVQAALWGFGRTTINEEPALHCRLVDCDGSSEAVD Mvan_1003|M.vanbaalenii_PYR-1 VTERAVAAEAGEPVDPVQSALWGLGRTLIAEEPGLRCLLVDLDGSEDAGP MLBr_00135|M.leprae_Br4923 LTRGAVGLVGEGISDLAAAAVWGMVRSAQSEHSGK-IVLIDTDSAVD--- MUL_2005|M.ulcerans_Agy99 LTHGAVAMPGENVSDLAGAAVWGIVRSAQAENPGR-IVLVDADAAVE--- MAV_3108|M.avium_104 STRGAVGLPGEDVADLAGAAVWGLVRSAQAEHPGR-VVLVDTDGSLD--- Mb2074c|M.bovis_AF2122/97 MTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGR-IVLVDSDAPLDD-- Rv2048c|M.tuberculosis_H37Rv MTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGR-IVLVDSDAPLDD-- MMAR_0101|M.marinum_M VTHGGVALTDEGVKDLAAAAVWGLVRSAQSEHPGR-IVLIDTDSAPTDPE MAB_3575c|M.abscessus_ATCC_199 --------------------------VAQPEHTGA-GI------------ TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ALAALLSTP-VDEPELAVRQGKLLASRLLPWSRSGHLTVPRGGDYVLAPT MSMEG_0408|M.smegmatis_MC2_155 LLAALLAAPGIQEPEIAVRQGKLLASRLLPWARSGHLTLPRGGDFVLAPT Mvan_1003|M.vanbaalenii_PYR-1 ALARLLGAP-GDEPELALRQGRLLVPRLLPWSRSGQLAIPRGTDYVLAPT MLBr_00135|M.leprae_Br4923 ----VAVLADLGESQLLVRCNTVHAARLSPAPQ--LLALPVGESMWRLAA MUL_2005|M.ulcerans_Agy99 ----AAELVAVGEPQLVVRSGAAHAARLAPAAP--LLAVPADESAWRLAA MAV_3108|M.avium_104 ----LATVIGCGEPQLVVRDGVAYRARLRPAGRRALLELPGPPAVWRLAA Mb2074c|M.bovis_AF2122/97 --SALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAM Rv2048c|M.tuberculosis_H37Rv --SALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAM MMAR_0101|M.marinum_M VLMDLANLAGRGEPQLLVSGGAVYGARLAPIPP----------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ERGAIDN---LRLTDSEVPPPAEGYVQVRVEAAGLNFRDVLNVLGLYPGD MSMEG_0408|M.smegmatis_MC2_155 ERGAIDN---LRLTETDVPEPDEGYVQVRVEAAGLNFRDVLNVLGLYPGD Mvan_1003|M.vanbaalenii_PYR-1 ERGVLDN---LRVSETEVTAPPEGHVQVRVEAAGLNFRDVLNALGLYPGD MLBr_00135|M.leprae_Br4923 DGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAVGVNFRDVVAALGMYPGQ MUL_2005|M.ulcerans_Agy99 GGGGTLEDLVIEPCPEVQAPLAAGQVRVAVRAVGVNFRDVVAALGMYPGA MAV_3108|M.avium_104 GDAGTLEDLAVQEHP--AAELAPGQVRVRVAAAGVNFRDVLVALGMYPGA Mb2074c|M.bovis_AF2122/97 STAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDP Rv2048c|M.tuberculosis_H37Rv STAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDP MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PGPIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQGAFASRFNVPGQFLAPI MSMEG_0408|M.smegmatis_MC2_155 PGPIGGDFAGTVTQLGAGVSGLEIGQRVYGSMQGAFASRFNVPAQFLAPI Mvan_1003|M.vanbaalenii_PYR-1 PGPIGGELAGVVTAPGPDVDGFDVGQRVFGFAVGAFASRVNVPVQFLAPV MLBr_00135|M.leprae_Br4923 APPLGAEGAGVVIEIGPEVTGVAVGDAVMGFLGG-AGPLAVVHQQLITQM MUL_2005|M.ulcerans_Agy99 APPLGAEGAGVVLEVGPQVSGVAVGDSVMGFLGG-AGPLSVVDQQLITRM MAV_3108|M.avium_104 AQ-LGAEGAGVVTEVGAGVTDVAVGDAVMGIFGL-VGSEAAVDRRLVTRV Mb2074c|M.bovis_AF2122/97 DAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKV Rv2048c|M.tuberculosis_H37Rv DAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKV MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PDGVSAVEAATIPAAALTVR-LSFDWAQVKSGDKVLIHAASGGVGLAAVQ MSMEG_0408|M.smegmatis_MC2_155 PDGIGAVEAATIPAAALTVR-LAFDWAQLKPGDKVLIHAASGGVGLAAIQ Mvan_1003|M.vanbaalenii_PYR-1 PEGISAVAAATTPAAVLTAG-LAFDWAALRAGDRVLIHAASGGVGLAAVQ MLBr_00135|M.leprae_Br4923 PQGWSLAEAAAVPVVFLTALFGLADLAGIRAGESVLIHAGTGGVGMAAVQ MUL_2005|M.ulcerans_Agy99 PQGWSFAQAAAVPVVFLTALFGLQDLAKIQPGESVLIHAGTGGVGMAAVQ MAV_3108|M.avium_104 PPGWSMAQAAGIPVVFLTAYYGLSVLAGLRAGQRVLVHAATGGVGMAAVQ Mb2074c|M.bovis_AF2122/97 PAGWSHTAAATTSVVFATAHYALVDLADVQPGQRVLIHAGTGGVGMAAVQ Rv2048c|M.tuberculosis_H37Rv PAGWSHTAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQ MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK MAQQCGAEVYATASTFKRATLRKLG--VKHVYDSRTTDFAEQILADTDGA MSMEG_0408|M.smegmatis_MC2_155 MAQQSGAEVFATASTFKRSTLRRLG--VKYVYDSRTTDFADQILADTNGA Mvan_1003|M.vanbaalenii_PYR-1 LARQRGATVFATASGYKRPMLRAMG--VDHVYDSRTTDFADQILADTDGA MLBr_00135|M.leprae_Br4923 FARHWGVEIFVTASRGKWDTLRDMGFDDDHIGDSRTLEFEEKFLAVTDGR MUL_2005|M.ulcerans_Agy99 LARHWGVEIFVTASRGKWDTLRAMGFDDDHIGDSRTLDFEEKFLAVTDGR MAV_3108|M.avium_104 LARHWGAEVFATASRGKWDTLRAMGFDDAHIADSRTLDFEQKFGAAPG-- Mb2074c|M.bovis_AF2122/97 LARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGR Rv2048c|M.tuberculosis_H37Rv LARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGR MMAR_0101|M.marinum_M ---------ALSATDGDCPTS----------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDIWTVEQMAAARPDLA MSMEG_0408|M.smegmatis_MC2_155 GVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKRDIWSHEQMAEARPDIA Mvan_1003|M.vanbaalenii_PYR-1 GVDVVLNSLTNDGFVAATVRATARNGRFAEIAKRDIWSPEQMAAARPDID MLBr_00135|M.leprae_Br4923 GVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQ MUL_2005|M.ulcerans_Agy99 GVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDIRDADKIAANYPGVW MAV_3108|M.avium_104 GMDVVLNSLAGE-FNDASLRLLGPGGRFIEMGKTDLRDPDVVARAHPGVR Mb2074c|M.bovis_AF2122/97 GFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVR Rv2048c|M.tuberculosis_H37Rv GFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVR MMAR_0101|M.marinum_M -------------------------------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK YEIVALDTVMFTEPDRIRDLLTEVSAGLRDGAWTPLPAEVYPLTEARAAF MSMEG_0408|M.smegmatis_MC2_155 YEIVALDTVMFTEPDRIRDLLTEVSDGMARGEWTPLPAEIYPITEARSAF Mvan_1003|M.vanbaalenii_PYR-1 YEVLALDAVMQQDPDRIQLLLADLADSLARGETAPLPFEAYPLAEATTAF MLBr_00135|M.leprae_Br4923 YRAFDL---SEAGPVRMQEMLCEVRELFDTQVLHRLPVTSWDVRCAPAAF MUL_2005|M.ulcerans_Agy99 YRAFDL---SEAGPVRMQEMLAEVRELFDTAVLHRLPVTTWDVRCAPAAF MAV_3108|M.avium_104 YRAFDL---MEAGPDRIAAMLAEVMELFAAGALTPLPVKAFDARCAADAY Mb2074c|M.bovis_AF2122/97 YRAFDL---FEAGPDRIAQILAELATLFGDGVLRPLPVTTFDVRRAPAAL Rv2048c|M.tuberculosis_H37Rv YRAFDL---FEPGPDRIAQILAELATLFGDGVLRPLPVTTFDVRCAPAAL MMAR_0101|M.marinum_M -----------DGPAELASVLDP--------------------------- MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RRMQQARHIGKIVVQIP-NPLQPQPDRSYLITGGLGAIGLHTAGYLAQLG MSMEG_0408|M.smegmatis_MC2_155 RRMQQARHIGKIVLQVP-KPLQPQQDRSYLITGGLGAIGLHTAAYLAQLG Mvan_1003|M.vanbaalenii_PYR-1 RRMQQARHTGKIILQMP-KPLQPHGDRSYLITGGLGALGLHAAAYLAQLG MLBr_00135|M.leprae_Br4923 RFMSQARHIGKVVLTMPSALADGLAEGTVLITGASGAIGGVLARHMVSAY MUL_2005|M.ulcerans_Agy99 RFMSQARHIGKVVLTMPSALADGLADATVLITGATGAVGAVLARHMLDGY MAV_3108|M.avium_104 RFVSAARHIGKVVLTMPDGPAG-LSGGTALITGATGMAGAALARHLVARH Mb2074c|M.bovis_AF2122/97 RYLSQARHTGKVVMLMP----GSWAAGTVLITGGTGMAGSAVARHVVARH Rv2048c|M.tuberculosis_H37Rv RYLSQARHTGKVVMLMP----GSWAAGTVLITGGTGMAGSAVARHVVARH MMAR_0101|M.marinum_M -------------------------AGTVLITGGTGMAGGVLARHVVGAG MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -AGDIVLTSRRAPDAAAQQAIADIADRTKARLHVFTADVGVEADVAALLE MSMEG_0408|M.smegmatis_MC2_155 -AGDIVLTSRRDPDESAQRAIDEITERHKCRIHTYAADVGDEAQVADLLA Mvan_1003|M.vanbaalenii_PYR-1 -AGDIVLTGRRMPDAATERAISEIAERYHCRIHTFAADVGDESAVRDLLE MLBr_00135|M.leprae_Br4923 GVRHLVLASRRGDRAEGAVELAAELVGAGAKIQVVACDVADNDAVRGLFA MUL_2005|M.ulcerans_Agy99 GVRHLVLASRRGDRAEGAAELAAELSEAGANVQVVACDVADRDAVEAMLA MAV_3108|M.avium_104 RVPHLMLVGRRGEAAPGMAELAAELRGAGASVSVLSCDVGDRDAVAAMLA Mb2074c|M.bovis_AF2122/97 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIA Rv2048c|M.tuberculosis_H37Rv GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIA MMAR_0101|M.marinum_M GVRHVVLASRQGEQAPGVAELVSELSAAGAEVLVLACDVADRDAVAQMME MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RIRAELPPLAGVAHLAGVLDDALLSQQSVERFRTALAPKAFGAVHLDRLT MSMEG_0408|M.smegmatis_MC2_155 RIRAELPPLAGIAHLAGVLDDALLSAQNPERFRTTLAPKAYGASHLDRLT Mvan_1003|M.vanbaalenii_PYR-1 RIRTELPPLAGVAHLAGVLDDALLPQQSPERFRTTLAPKAFGAWHLHRLT MLBr_00135|M.leprae_Br4923 QLSREFPPVRGVIHAAGVLDDGAITSLTPDRVDTVLRAKVDAAWNLHEAT MUL_2005|M.ulcerans_Agy99 RLSGEYPPVRGVIHAAGVLDDAVISSLTPERIDTVLRAKVDAAWNLHEAT MAV_3108|M.avium_104 QVPARYP-LRSVFHAAGVLDDAVIASLTPARIDTVLRAKVDGAWNLHELT Mb2074c|M.bovis_AF2122/97 DIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELT Rv2048c|M.tuberculosis_H37Rv DIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELT MMAR_0101|M.marinum_M QVRRRCPPLTGVIHAAGVLDDTVIASLTPDRMNPVLRAKVDGAWHLHQLT MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RVDDLDFFLVSSSVSSLFGSPGQSNYATANAFLDGLVAQRRAQGLPATGV MSMEG_0408|M.smegmatis_MC2_155 RDDDLDFFIVSSSVSSLFGSPGQANYATANAMLDGLVAKRRAQGLVATGI Mvan_1003|M.vanbaalenii_PYR-1 RDTELEFFIVYSSGSSVLGSPGQANYATANAVLDGLVAHRKARGLPATGV MLBr_00135|M.leprae_Br4923 RDLDLLMFVLCSSIAATVGSPGQGNYSAANAFLDGLAAYRQAAGLAGTSL MUL_2005|M.ulcerans_Agy99 LDLDLSMFVLCSSIAATVGSPGQGNYSAANSFLDGLAAHRQAAGLAGISV MAV_3108|M.avium_104 KDLDLSAFVVFSSMAGIVGAPGQGNYAAANSFLDALAIHRHAHGLPALSV Mb2074c|M.bovis_AF2122/97 RDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISL Rv2048c|M.tuberculosis_H37Rv RDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISL MMAR_0101|M.marinum_M RGLGLSMFVLCSSIAGVMGSPGQGNYAAANTFLDALAAHRRATGLAGLSV MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NFGPWARGGMASSEAAAAN---ISAQGLIPLEPSAALTAMAEVVANGTAQ MSMEG_0408|M.smegmatis_MC2_155 NFGPWGQGGMASSEAATAN---ITAQGLIPLDPSAALHALAEVIANGSGQ Mvan_1003|M.vanbaalenii_PYR-1 NWGPWAQGGMATSDAARAN---LGAQGLIPLEPTAALNALGEIVAHGIAS MLBr_00135|M.leprae_Br4923 AWGLWEQPGGMNAHLSSRDLARISRSGLAPMNPAQALELFDAALVIDHPF MUL_2005|M.ulcerans_Agy99 AWGLWEQSGGMAAHLSSRDLARMSRSGLAPMNPEQAVGLLDAVLAINHPL MAV_3108|M.avium_104 AWGMWEEPSAMTAHLEERDKARMSRAGLSALSTRQALDLLDDALLGEQPL Mb2074c|M.bovis_AF2122/97 GWGLWDQASAMTSGLATVDFKRFARDGIVAMSSADALQLFDTAMIVDEPF Rv2048c|M.tuberculosis_H37Rv GWGLWDQASAMTGGLATVDFKRFARDGIVAMSSADALQLFDTAMIVDEPF MMAR_0101|M.marinum_M QWGLWEQTSAMTGHLGERDLARIRRSGLAPMSVGQAVELFDAAVLLDRST MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ATVLKANWQRAAKVLGSSRPPILDLVLPSAVG---------EITGDSELL MSMEG_0408|M.smegmatis_MC2_155 ATVLKANWQRAAKVLGSARPPILDLVLPSAAG---------EATGDSELL Mvan_1003|M.vanbaalenii_PYR-1 AVVLKANWQRAAKLLGATRPPILDHVLPSAVA---------AGPGDSALL MLBr_00135|M.leprae_Br4923 MVTALLDRAALDAQAQAGALPPLFSRLVRRSRRRQIEDPGDATQSKLALV MUL_2005|M.ulcerans_Agy99 MVATLLDRPALEARAQAGGLPPLFAGVVRRPRRRQIEDTGDAAQSKSALA MAV_3108|M.avium_104 VVGTRLDRAALAQHRAA--LPPLLSELAGRPARRMLEHTDMVSLTG--LR Mb2074c|M.bovis_AF2122/97 MLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSLAAAKSKSALA Rv2048c|M.tuberculosis_H37Rv MLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSLAAAKSKSALL MMAR_0101|M.marinum_M VVAACLDRNALASPAVSAELPMLFHSLLPRPSRRVIN--KDATTHESGLA MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK KQLQEIPVPQRAGFVTEFLQKEVQNFLRLAQPPAATS--RFLDLGTDSLM MSMEG_0408|M.smegmatis_MC2_155 KQLMEIPIPQRAGFVTEFLQREVQNFLRLASPPAASS--RFLDLGTDSLM Mvan_1003|M.vanbaalenii_PYR-1 KQLQDVPEAQRGSFVTEHLQRELQQILGLAQPPAATG--RFLELGMDSLM MLBr_00135|M.leprae_Br4923 QRLQGLAANRQLELLVGVVCLQAAAVLGRPSPEDIDPNTKFQDLGFDSLT MUL_2005|M.ulcerans_Agy99 ERLNGLSAGERQDALVGLVCLQAAAVLGRPSPEDIDPEAGFQDLGFDSLT MAV_3108|M.avium_104 ARLAGMNPEQRQAELVELVCGNAAAVLG-HSTADVDPGDAFSDLGFDSLT Mb2074c|M.bovis_AF2122/97 HRLHGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQDLGFDSLT Rv2048c|M.tuberculosis_H37Rv QRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT MMAR_0101|M.marinum_M QRLQALSPHQQHQLLVETVRNQAAVVLGRPSGQDIDPECTFQDLGLDSLT MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AIELRNRLHSQFGGAFTINATAVFDYPTIGGLAEYLVAQLPDAETPQAAP MSMEG_0408|M.smegmatis_MC2_155 AIELRNRLHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDAEAPETA- Mvan_1003|M.vanbaalenii_PYR-1 AVELRNRLVGQFGSGFTITATAVFDYPTIGALAEYLAAQTPESTEEGTEM MLBr_00135|M.leprae_Br4923 AVELRNRLKSATG--LTLPPTVIFDHPTPTAVAEYVAQQMLKSRPAESGD MUL_2005|M.ulcerans_Agy99 AVELRNRFKSATG--LTLPPTVIFDHPTPTAIAEYVGRQIPDSQATQAEE MAV_3108|M.avium_104 AVELRNRLKIATG--LTLSPTVIFDHPTPAALAEHLGGQLTSAGPTPAAP Mb2074c|M.bovis_AF2122/97 AVEMRNRLKSATG--LSLSPTLIFDYPNSAALAGYMRRELLGSSPQDTSA Rv2048c|M.tuberculosis_H37Rv AVEMRNRLKSATG--LALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSA MMAR_0101|M.marinum_M AVELRNRLKAASG--LSLSPTLIFDYPTPATLARHLAQQLIGTGTTGSAQ MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QSESEPGPDVTE-------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 KTADPDGQPATVGHADVVLQTS---------------------------- MLBr_00135|M.leprae_Br4923 ETSQAVEPKVEEVSVHA--------------------------------- MUL_2005|M.ulcerans_Agy99 E--KLPESDGEMVSVTA--------------------------------- MAV_3108|M.avium_104 AETAAPPDRSSRIDEVVSELQTLLTQPGLSPGDRAQLVTRLQSLLSTPPQ Mb2074c|M.bovis_AF2122/97 VAAGEAELQRIVASIPVKRLR------------QAGVLDLLLALANETET Rv2048c|M.tuberculosis_H37Rv VAAGEAELQRIVASIPVKRLR------------QAGVLDLLLALANETET MMAR_0101|M.marinum_M IESQLETLQQTLLAIEDGDKQ--------------RVAAQLRKFLTRLLA MAB_3575c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ---------------------------------- MSMEG_0408|M.smegmatis_MC2_155 ---------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 ---------------------------------- MLBr_00135|M.leprae_Br4923 ---------------------------------- MUL_2005|M.ulcerans_Agy99 ---------------------------------- MAV_3108|M.avium_104 PSGHPEFPEDAFDDDIATATDSQLFAILDDEAGP Mb2074c|M.bovis_AF2122/97 SGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE- Rv2048c|M.tuberculosis_H37Rv SGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE- MMAR_0101|M.marinum_M PAESGRPLDDRIKDATSPSEILQLIDAGSIES-- MAB_3575c|M.abscessus_ATCC_199 ---------------------------------- TH_4458|M.thermoresistible__bu ----------------------------------