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MRNNNLAWLLANQALASEWSASPAYYAPNIVTHAQIHEGAARLGNVFGSRGLRTGDRVLLCLPDSTDLVQ LLLACLARGIVAFISNPELRPDDHTFQEQDTQPALVVTTDALRDRFARSGIVDPGELWAEANQAKPAAYE PLTGDALAYGTYTSGTTGAPKAALHRHGDVWAFIDAMCRNALRLTPDDVGLSIARMYFAYGLGNSVWFPL ATGSSAVISRSPLGAESAANLSERFSPSVLYGVPTFLARVADTCAADAFRSLRCVVSAGEALELGLAQRL MKFFGGIPLLDGIGSTEVGQTFISSTVDEWRLGTLGKVLSPYEIRVVAPDGTTAAPGVEGDLWVRGPSLT AGYWNRPTQPPSISDSWLDTRDRVCVDAHGWVTYRCRADDIEIVGGININPREIEQLIVEDHLVAETAVV AVREATGESALQAFLVPESGASLGESAIKELHRRLLGSLSPHKVPHRFEIAERLPRTASGKLQRGQLRTQ PAAQPVWERRCTVGTSDSDGQRDPQTQTNYKVGPRVGPVTLDERLAVLQQEGHRLIADTVSAEVAQILGD PAAERIDRDVAFAELGFDSRMTVELRNRLAAVTGLRLPETVGWDYGSISRLAAHLETELAGSGGRGKPGP SVAGGAPVAIVGVGCRYPGGVESAGGLWDVVVGGRDVISGFPVDRGWDVEGVFDPDPDALGKTYCRLGGF LDGADRFDAGFFGIGPSEALAMDPQQRLLLECSWEALEDAGIDPVSLRGSVTGVFTGLMSSDYGAGRVSG DLEGYGLTSAAASVASGRVAYLLGLEGPAVSVDTACSSSLVALHLAASSLRSGECDVALAGGVTVMATPA TFVGFSRQRGLAADGRCKAFAGAADGTGFSEGAGVVVLMRLSEARRRGLAVLGVIAGSAVNQDGASNGLT APNGPAQQRVIEAALANAGLTAADVDVVEGHGTGTTLGDPIEAQALLATYGQARPADQPLWLGSIKSNMG HTQAAAGIAGVIKMVQAMRHELMPATLHVDVPSPHVDWSSGAVSLLTQPRPWPAVDGRPRRAGVSSFGIS GTNAHVIVEQVCPEVVAEAVDVSPDSLPWVVSGKSEAAVAAQAKRLLAAVQADEGLDRLDVGFSLARRTA FEYRAVVLGEDRQQLISGLTELAAGQPGPTVLNGRAATVSKTVMVFPGQGSQRLGMGQQLHGQFPVFAQA FDAVVEQLDRYLRLPLRDALWGGDEHLLESTEFAQPSLFAVEVALFALLRDWGVSPDVVMGHSVGELSAA HVAGVLTLDDAAKLVAARGRLMQALPEGGAMFAIAASEHEVSPLLGEAVGIAAINAPDAVVISGERAAVG VLAEELIDRGRRVHRLAVSHAFHSPLMEPMLADFALAAGDITAHPPRIALVSNLTGELAGPDYGSAQYWV EHVRRPVRFADSVRNLEELGASHFIEVGPGGGLSSAIAQSLRSPEAVTVPVLGKDRPEVNSLISAVGQLF STGVGVDWSAVFAGSGGRQVGLPTYAFARRRFWLDGSASAADVGEAGLVAAGHALLGAVVEQPDTGAVVL TGRLSLARQPWLADHLVGGAVLFPGTGFVELAIRAGDEVGCGVVEELTLATPLVLNAGTAVQVQVVVGSA GQSGQRLVSMYSRADQPDQHWVLHAQGSVAPAAVQPAAAASAELSTWPPAGAEAVDIGGLYERLARRGYG YGPAFQGLRAVWRRGRDVFAEVGLPNDEGLDLTDVGIHPALLDAVLHATMAAAGADVAEMRLPFSWRGVS LHAAGAAGLRARIAALDGGDGAAVSVELADAAGLPVLSVDSLVTRPVTANQLNAAIAAAAGAPDDKLLEV AWSPIALNDRTIGGRDDVPVMLWDDHRDDDGHGAGTVVIWESCCAADDDVVRSAYAATHAALAVLQSWLS GDRPGTLVIVTHGGVALTDEGVKDLAAAAVWGLVRSAQSEHPGRIVLIDTDSAPTDPEVLMDLANLAGRG EPQLLVSGGAVYGARLAPIPPALSATDGDCPTSDGPAELASVLDPAGTVLITGGTGMAGGVLARHVVGAG GVRHVVLASRQGEQAPGVAELVSELSAAGAEVLVLACDVADRDAVAQMMEQVRRRCPPLTGVIHAAGVLD DTVIASLTPDRMNPVLRAKVDGAWHLHQLTRGLGLSMFVLCSSIAGVMGSPGQGNYAAANTFLDALAAHR RATGLAGLSVQWGLWEQTSAMTGHLGERDLARIRRSGLAPMSVGQAVELFDAAVLLDRSTVVAACLDRNA LASPAVSAELPMLFHSLLPRPSRRVINKDATTHESGLAQRLQALSPHQQHQLLVETVRNQAAVVLGRPSG QDIDPECTFQDLGLDSLTAVELRNRLKAASGLSLSPTLIFDYPTPATLARHLAQQLIGTGTTGSAQIESQ LETLQQTLLAIEDGDKQRVAAQLRKFLTRLLAPAESGRPLDDRIKDATSPSEILQLIDAGSIES
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_0101 | - | - | 100% (2444) | polyketide synthase PKS |
M. marinum M | MMAR_3796 | - | 0.0 | 58.28% (1764) | type I modular polyketide synthase |
M. marinum M | MMAR_0102 | - | 0.0 | 72.78% (1407) | polyketide synthase PKS |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2971c | pks1 | 0.0 | 66.86% (1361) | polyketide synthase PKS1 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 37.45% (1546) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv2048c | pks12 | 0.0 | 59.76% (1476) | polyketide synthase pks12 |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 63.61% (1418) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 39.58% (1281) | polyketide synthase |
M. avium 104 | MAV_2450 | - | 0.0 | 60.54% (1447) | erythronolide synthase, modules 3 and 4 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 37.79% (1519) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_2454 | - | 0.0 | 31.93% (1826) | PUTATIVE beta-ketoacyl synthase |
M. ulcerans Agy99 | MUL_2005 | pks15/1 | 0.0 | 62.35% (1458) | polyketide synthase Pks15/1 |
M. vanbaalenii PYR-1 | Mvan_0269 | - | 0.0 | 37.13% (1535) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment MAB_0939|M.abscessus_ATCC_1997 ------------------------MDSAENPIESTPRFAIIGYAARFPG- Mvan_0269|M.vanbaalenii_PYR-1 ------------------------MGSAEHPNGPAPRFAIVGYAARFPG- Mflv_0405|M.gilvum_PYR-GCK ------------------------MGSAAHQGESAHRFAIVGYAGRFPG- MSMEG_0408|M.smegmatis_MC2_155 ------------------------MVSAEHPIEPTPSFAIIGYAARFPG- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG MAV_2450|M.avium_104 MMVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AADAEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVVTRRAGF Mvan_0269|M.vanbaalenii_PYR-1 APDADAFWDVLREGRDAISDVPRDR-WDAEEFFDPEPGAPGKVVTRRAGF Mflv_0405|M.gilvum_PYR-GCK ARDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVVTRRAGF MSMEG_0408|M.smegmatis_MC2_155 AASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVVTRRAGF Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGF MAV_2450|M.avium_104 VDSPEALWQMVAEGRDVISEFPTDRGWDLAALYDPDPDARHKCYVNTGGF TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VEDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAPTDLAET Mvan_0269|M.vanbaalenii_PYR-1 VDDVTGFDAPFFGMSTREVRMMDPQHRLLLETAWRAVEHSGTAPTALAGS Mflv_0405|M.gilvum_PYR-GCK VDDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANT MSMEG_0408|M.smegmatis_MC2_155 VDDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANS Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS MAV_2450|M.avium_104 VDNVADFDPAFFGIAPSEALAMDPQHRMLLELSWEALERAGIDPSGLRGS TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 NSGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRISYRLGLQ Mvan_0269|M.vanbaalenii_PYR-1 NTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQ Mflv_0405|M.gilvum_PYR-GCK NTGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQ MSMEG_0408|M.smegmatis_MC2_155 NTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQ Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv ATGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLE MAV_2450|M.avium_104 ATGVFAGLIVQGYG------MLAEEIEGYRLTGMTSSVASGRVSYVLGLE TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GPSVAVDTACSSSLVAIHQACQALQLGECDLALAGGANVLLTPATMITFS Mvan_0269|M.vanbaalenii_PYR-1 GPAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVLLTPATMITFS Mflv_0405|M.gilvum_PYR-GCK GPAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVILTPATMITFS MSMEG_0408|M.smegmatis_MC2_155 GPAVAVDTACSSSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFS Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv GPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFS MAV_2450|M.avium_104 GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 HAHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDRIRAVIR Mvan_0269|M.vanbaalenii_PYR-1 NAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIR Mflv_0405|M.gilvum_PYR-GCK NAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIR MSMEG_0408|M.smegmatis_MC2_155 NAHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIR Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv RHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV MAV_2450|M.avium_104 RHRGLAPDGRCKAYAGAADGVGWSEGGAMLVVERLSDARRLGHPVLAVVR TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GSAINQDGASGGLTVPNGVAQQRVIADALKRAGVAPSEVGYLEAHGTGTS Mvan_0269|M.vanbaalenii_PYR-1 GSSINQDGASGGLTVPNGVAQQRVIADALKRSDLEPKDVGYLEAHGTGTS Mflv_0405|M.gilvum_PYR-GCK GSAINQDGASGGLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTS MSMEG_0408|M.smegmatis_MC2_155 GSAINQDGASGGLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTS Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MAV_2450|M.avium_104 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LGDPIEAQAAGAAYGIGRETNDPLLIG-SAKTNIGHLEAAAGIAGVIKVI Mvan_0269|M.vanbaalenii_PYR-1 LGDPIEAQAAGAVLGAGREPSRPLLIG-SAKTNIGHLEAAAGIAGVIKVI Mflv_0405|M.gilvum_PYR-GCK LGDPIEAQAAGAALGPGREPQRPLLIG-SAKTNIGHLEAAAGIAGVIKVV MSMEG_0408|M.smegmatis_MC2_155 LGDPIEAQAAGEVLGAGRAPEEPLLIG-SAKTNIGHLEAAAGIAGVIKVV Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMV MAV_2450|M.avium_104 LGDPIEAQALLATYGQDRGQP---LWLGSIKSNMGHTQAAAGVAGVIKMV TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LSLENELLPQHRNFQNPSPHIPWDRLPVEVVREARPWGRN---GRPRIAG Mvan_0269|M.vanbaalenii_PYR-1 LSLEHRTLPKHLNFENPSPHIPWDRLAVEVVKETIPWERD---GGPRIAG Mflv_0405|M.gilvum_PYR-GCK LSLEHETLPKHLNFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPRIAG MSMEG_0408|M.smegmatis_MC2_155 MALENETLPKHLNFETPSPHIPWERLPIEVVRETVPWQRN---GKPRIAG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAGARTRRAGVS- MAV_2450|M.avium_104 LAMRHELLPATLHVDEPSPHVDWSAGAVSLLTEAQPWPG-ERPRRAGVS- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VSSFGFAGTNAHVILEEAPVVSRDAVEPPAPAGGRKFSILPLSARTPAAL Mvan_0269|M.vanbaalenii_PYR-1 VSSFGFAGTNAHVILEEAP--EQAAAPGPVQQPDRRFSLLPLSARTPAAL Mflv_0405|M.gilvum_PYR-GCK VSSFGFAGTNAHVILEEAP---LAAEPAQESVDDGRFTLLPLSARTPAAL MSMEG_0408|M.smegmatis_MC2_155 VSSFGFAGTNAHVILEEAPAVGTPATTEPVE-DPRRYSVLPLSARTPEAL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv --SFGISGTNAHVIIEAVP-VVPRREAGWAGPVVPWVVSAKSESALRGQA MAV_2450|M.avium_104 --SFGISGTNAHVIIEAVPAVEPAHADAPALPVLPWVVSAKSAAALRAQA TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AQLADKYRAWLNAHPEAALADLCFTAGVGRAHLEHRAALVVNTREAAVEL Mvan_0269|M.vanbaalenii_PYR-1 TQLAGQYRDWWTAHPEATLADVCFTAGAGRAHLEHRAALVVNSAESAVEL Mflv_0405|M.gilvum_PYR-GCK MAVADRYRDWLVANPDATLADLCFTAGTARSHLEHRAALVVNTREAALDL MSMEG_0408|M.smegmatis_MC2_155 VRLAGEYRDWLRAHPQARLADVSHTAGTARAHLEQRAALVVNSRESAIEL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv ARLAAYVRGDDGLDVADVGWSLAGRS-----VFEHRAVVVGGDRDRLLAG MAV_2450|M.avium_104 ARLAEYVRAQGELDIADVGWTLAGRA-----TFEHRAVVVGGDRDRLLAG TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LSAVADDRPAPGLGRGESHDTPKTAWLFTGQGSQYPGMARELFETEPVFA Mvan_0269|M.vanbaalenii_PYR-1 LGALADDRPAPGLVRGESHDTPKTAWLFTGQGSQYPGMARELYDTEPVFA Mflv_0405|M.gilvum_PYR-GCK LGALADDRPAPGLVRGESHDTPKTAWLFTGQGSQYPGMSRELFDTEPLFA MSMEG_0408|M.smegmatis_MC2_155 LGALADDRPAPGLVRGESHEAPKTAWLFTGQGSQYPGMARELFDTEPVFA Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFA MAV_2450|M.avium_104 LDELAADDPAASIIRGVATPAGKTVFVFPGQGSQWLGMATELLDTAPVFA TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DTLNRCAAAVADVLEKPLLDVIFDVD---GPEAEETLRQTSYAQPALFAV Mvan_0269|M.vanbaalenii_PYR-1 ETLNRCAEAVADVLEKPLLDVIFDAE---ADDAEKTLQNTCYAQPALFAV Mflv_0405|M.gilvum_PYR-GCK ETLRECAAAVDGMLEKPLLDVIFDTDGVLDTDSNETLRHTSYAQPALFAV MSMEG_0408|M.smegmatis_MC2_155 ETVRKCAEAVADILEKPLLDVIFDAD-ELDGDTESPLRHTTYAQPALFAV Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv QQIDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPVLFAV MAV_2450|M.avium_104 QHIQACEEAFAEFVDWSLIDALRGAP------GAAGMDRVDVVQPALFAV TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EMGLARLWQSWGFEPDVVLGHSVGQYSAACVAEVFSLEDGARLIAERGRL Mvan_0269|M.vanbaalenii_PYR-1 EMGLARLWQSWGFEPDVVLGHSVGQYSAACVAGVFSLTDGARLMAERGRL Mflv_0405|M.gilvum_PYR-GCK EMGLARLWQSWGFEPDVVLGHSVGQYAAACVAGVLSLRDGARLMAERGRL MSMEG_0408|M.smegmatis_MC2_155 ELGLARLWQSWGFEPDVVVGHSVGQYSAACVAGVFDVEDGARLIAERGRL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv MVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKL MAV_2450|M.avium_104 MVSLAELWKSVGVSPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKL TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 FSSLPAGGRMAAVFTDAERAERLTDEFPSLS--VAAYNGANTVLSGPAQD Mvan_0269|M.vanbaalenii_PYR-1 FGSLPEGGRMVAVFTTAERAEAMTDEFPSLS--VAAYNGTNTVLSGPAGD Mflv_0405|M.gilvum_PYR-GCK FGSLPSGGRMAAVFAAAERVEALTDEYPALS--VAAYNGANTVLSGPATD MSMEG_0408|M.smegmatis_MC2_155 FGSLPAGGRMAAVFTAPERAERLTDEYPSLS--VAAYNGANTVLSGPAKD Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSGEVGA MAV_2450|M.avium_104 LRSLAGPGGMLSIACSTERARELLAPYGNRVSIAAVNGRSAVVVSGEGAA TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LEKAIAALVADGVRCDFLETSHAFHSALLDPILDEFEAYANQFNYKTPQR Mvan_0269|M.vanbaalenii_PYR-1 LEKAVATLSADGVRCDWLDTSHAFHSALLDPILDDFESYANQFDFAAPQR Mflv_0405|M.gilvum_PYR-GCK LERAVAGLVADGVRCDWLETSHAFHSALLDPILDDFESYARGITFTAPQR MSMEG_0408|M.smegmatis_MC2_155 LESAVATLVADGVRCDWLDTSHAFHSALLDPILDDFESFAQKLEYREPQR Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRT MAV_2450|M.avium_104 LDELAAFCADLALRTRRIDVDYASHSVEVEAIREDLAQALTGIEPRSSRI TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ILIDNRTGTALGRSVKLDGAYWRRHARQPVEFAKSVRTLADMNCKVLLEI Mvan_0269|M.vanbaalenii_PYR-1 ILIDNRTGTALGRSVQLDGTYWRRHARQPVEFAKSVRTLAEMNCKLLVEI Mflv_0405|M.gilvum_PYR-GCK ILIDNRTGAALGRSVTLDAAYWRRHARQPVEFAKSVHTLADMNCKLLVEI MSMEG_0408|M.smegmatis_MC2_155 ILIDNRTGSALGRSTRLDGAYWRRHARQPVEFAKSVRTLADMNCRVLLEI Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VFFSTVTGNRL-DTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIES MAV_2450|M.avium_104 AFFSTVTGNRL-DTAGLDADYWYRNIRQTVQFDQTVRSAAEHGYRTFIES TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GPQPVLTAAALRAWPDPATAPRAIASLRRNTADHRQITEAAADAYVLGHL Mvan_0269|M.vanbaalenii_PYR-1 GPRPVLTAAALGAWPDPATAPRVIASLRRTAADHRQITEAVADAYVLGHL Mflv_0405|M.gilvum_PYR-GCK GPRPVLTAAALSAWPDPATSPRVIASLRRTTADQRQITEAVADAYVLGHL MSMEG_0408|M.smegmatis_MC2_155 GPRPVLTATALAAWPDPATTPQVLASLRPTTADHRQITEAVAAAYAAGHL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv SPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVA MAV_2450|M.avium_104 SPHPALVAGIEDTVNDSLPGDTEAIVIPTLGRDDGGLERFLTSAATAFVA TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PDFGAFQ--HAPARKLDLPTYPFERRQYWFSDKRDGDNRDAGNRQQNNGG Mvan_0269|M.vanbaalenii_PYR-1 PEFGAFR--DAGARKLDLPTYPFEHRQYWFRDNQDPD----GSEALQPRT Mflv_0405|M.gilvum_PYR-GCK PRFAAFR--RDGARVLDLPTYPFEHRQYWFSDSREPV------AAAPQRG MSMEG_0408|M.smegmatis_MC2_155 PDFRAFR--QPDARKLDLPTYPFEHRQFWFSDNRAIDRDTQTASAGSVTP Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv GVAVNWRGTLDGAGYVELPTYAFDKRRFWLSAEGSGADVSGLGLGASEHP MAV_2450|M.avium_104 GVNVAWRGVLDGAGFVELPTYAFDRRRFWLSGEGAAADASGLGLGTSEHP TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PRTEAVRLLEDGKIEELANLLGGVDGDQQTLNVLTKLAAQHN-------- Mvan_0269|M.vanbaalenii_PYR-1 PSTEAVRLLEDGRIEELATLLDGAAGDQQTLDVLSRLAAQHN-------- Mflv_0405|M.gilvum_PYR-GCK ARTETVRLLEDGRIEELAALLGGTVDDPFTFDVLNRLAAQHN-------- MSMEG_0408|M.smegmatis_MC2_155 HRTQAVRLLEDGQIEELAALIDGETVDEQTLRVLNKLAARHN-------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGFVELAIR MAV_2450|M.avium_104 LLSAVVELPASGGVVLTGRLSPSLQGWLTDHAVSGTVVFPGAGFVELAIR TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv AGDEVGCSVLDELTLAAPLLLPAT----GSVAVQVVVDAGRDSNSRGVSI MAV_2450|M.avium_104 AGDEVGCSTVEELTLQAPLMLPAKDSGIGSVAVQVLVGEADESGRRDVSI TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv FSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLA MAV_2450|M.avium_104 FSRPDSDSPWVCHAQGTLSTGSIEPGADLAAWPPAGATKVDIADGYQRLA TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv TRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVL MAV_2450|M.avium_104 ARGYGYGPAFQGLTAAWVRGDEVFAEVRLPDAAGGVTGFGVHPALLDAAM TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv HAVVI----AGDPDELALPFAWQGVSLHATGASAVRARIAPAGPS----- MAV_2450|M.avium_104 HALIVGHQIAGDTDEVALPFAWQGVSLHAAGASAVRARLAPAQAPGTAAS TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -----------------LQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGV Mvan_0269|M.vanbaalenii_PYR-1 -----------------QQRSSQSITNDRYEIRWEQSAAALSGAETDEVS Mflv_0405|M.gilvum_PYR-GCK -----------------QQRSTESIADDRYQIRWETAAEPPVGADAADGI MSMEG_0408|M.smegmatis_MC2_155 -----------------QQRSTHVDPDARYEIRWDAIAS--AAASTGAAA Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -----------------------------MRNNNLAWLLANQALASEWSA Rv2048c|M.tuberculosis_H37Rv -AVSVELADGLGLPVLSVASMVARPVTERQLLAAVSGSGPDRLFEVIWSP MAV_2450|M.avium_104 RAVSLELADGLGLPVLSVRAMVARSVSERQLRAAVSAAGPDRLFEVAWAP TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 TWLLVADAAGAAQPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAAD Mvan_0269|M.vanbaalenii_PYR-1 SWILVGDDTEATRPLVDVLSARGQRYRIFGLPVSDADEEQLGEALRLAAA Mflv_0405|M.gilvum_PYR-GCK TWLLVGDDTDATRPLVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAA MSMEG_0408|M.smegmatis_MC2_155 DWILVGDDTAAVLEFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASA Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M SPAYYAPNIVTHAQIHEGAARLGNVFGSRGLRTGDRVLLCLPDSTDLVQL Rv2048c|M.tuberculosis_H37Rv ASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALAAVQSWLTDHESG MAV_2450|M.avium_104 VTVPAAHGEPPVHQVFESLAAEGDPVGESYRRTHEALAAVQSWLTEHDSG TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EDSALRIVHVAALAGQ----GSSSAQSLLRIQHQVLGGTRRLFRAAAAAE Mvan_0269|M.vanbaalenii_PYR-1 EDSTLRIVHVGGLDSDPDPGTAPSMRSLLRMQHRILGGTRRLFRAAAAAE Mflv_0405|M.gilvum_PYR-GCK DATDLRIVHVAALDAA---ESDTSMKSLLRMQHRVLGGTRRLFGAAVAAQ MSMEG_0408|M.smegmatis_MC2_155 G--ELYVVHIAAGDGA-----AAPMRDLLRVQHRTLGGLRRLFRAANDAE Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M LLACLARGIVAF-------ISNPELRPDDHTFQEQDTQPALVVTTDALRD Rv2048c|M.tuberculosis_H37Rv VLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATD MAV_2450|M.avium_104 VLVVVTRGAMALAGEDVTDLSGAAVWGLVRSAQTEHPGRIVLIDSDAALD TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LRAPIWIVTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLS Mvan_0269|M.vanbaalenii_PYR-1 LRTPIWVVTRRAQHVTATDTVAPDQSCLWGFGRAAALELPQLWGGLADLA Mflv_0405|M.gilvum_PYR-GCK LRSPMWLVTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLG MSMEG_0408|M.smegmatis_MC2_155 LRSPIWLVTRDGQRVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLS Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M RFARSGIVDPGEL------------WAEANQAKPAAYEPLTGDALAYGTY Rv2048c|M.tuberculosis_H37Rv DAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLG MAV_2450|M.avium_104 DSALTAALATGEPQVLLRDGTVYTARVHGSRAVDGIMTPPEDRPWRLGIS TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DAGTDEWAQFIGRVSVSGEASTREDQLALRGQAVHVPRLVRREELPSGKP Mvan_0269|M.vanbaalenii_PYR-1 DGTADEWSRLLNRITAPHGPAVREDQIALRDHAVYVPRLVRRAGRPAGKP Mflv_0405|M.gilvum_PYR-GCK GGTSDEWSRLLNRIAATHDPAVMEDQVAVRGSTSYVPRLVHRDTLPSGKP MSMEG_0408|M.smegmatis_MC2_155 G-ADTEWPRLIARITSPRD---GEDQIALRGDAVYAPRLVRRTGEPSDTP Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M TSGTTG---------------------APKAALHRHGDVWAFIDAMCRNA Rv2048c|M.tuberculosis_H37Rv SAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDA MAV_2450|M.avium_104 SAGTFENLQLEPVPNPDAALQPGQVRVALRAIATNFRDVMITLGMFTHDA TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LEVRSDATYLVTGGLGSIGLEIAG------------------YLAGRGAK Mvan_0269|M.vanbaalenii_PYR-1 LQLRDDATYLVTGGLGSIGLEIAG------------------YLAAHGAR Mflv_0405|M.gilvum_PYR-GCK LHLRADATYLVTGGLGSLGLEIAG------------------YLAANGAG MSMEG_0408|M.smegmatis_MC2_155 LPVREDRTYLVTGGLGAIGLEVAG------------------YLASHGAG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M LRLTPDD-VGLSIARMYFAYGLGNSVWFPLATGSSAVIS---------RS Rv2048c|M.tuberculosis_H37Rv LLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPA MAV_2450|M.avium_104 LLGGEGAGVVVEVGPGVTEFSVGDSVYGFFPDGSGTLVPGDVRLLQHKPT TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 HLVLTSRREPGEAARQRIDALAAQG-CEVRAVTADVADGHDVARLLAGIQ Mvan_0269|M.vanbaalenii_PYR-1 HLVLTSRRAPGDATQQRIDALGAQHSCQIRVVAADVADAHDVARLLAAVA Mflv_0405|M.gilvum_PYR-GCK HLVLTSRRTPDEAAASRIEALRERHGCEVRVVTADVADAHAVARLLATVQ MSMEG_0408|M.smegmatis_MC2_155 HVVLTSRREPGDDARRRLDGLREQYACDVRVITADVADAHDVARLMTTVA Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M PLGAESAANLSERFSPSVLYGVPTFLARVADTCAADAFRSLRCVVSAGEA Rv2048c|M.tuberculosis_H37Rv DWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLA MAV_2450|M.avium_104 HWSYPEAAGISAVFTTAYMAFIHLADVKPGQRVLVHAAAGGVGMAAVQLA TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AELPPLAGIVHAAGEIGTTPLSDLEDAEVDRVFAGKVWGAWHLSEAAAGL Mvan_0269|M.vanbaalenii_PYR-1 AELPPLAGIVHAAGEIGTTPLVSLEDSEVDRVFAGKVWGAWHLSEAAADL Mflv_0405|M.gilvum_PYR-GCK AEMPPLAGIVHAAGEIGTTPLADLDDAEVDRVFAGKVWGAWHLSEATSDL MSMEG_0408|M.smegmatis_MC2_155 AELPPLAGIVHAAGEIGTTPLSGLDDAEVDRVFAGKVWGAWHLSEALTDL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M LELGLAQRLMKFFGGIPLLDGI--GSTEVGQTFISSTVDEWRLGTLGK-- Rv2048c|M.tuberculosis_H37Rv RHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGF MAV_2450|M.avium_104 RHLGLEVFATASRGKWDTLRAMGFDDDHIGDSRTLEFEDKFRSATGGAGM TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 K--LDFFINTSSIAAVWG-------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 Q--LDFFLGTSSIASVWG-------------------------------- Mflv_0405|M.gilvum_PYR-GCK Q--LDFFISTSSIASVWG-------------------------------- MSMEG_0408|M.smegmatis_MC2_155 RTDLDFFVSTSSIASVWG-------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M --VLSPYEIRVVAPDGTTAAPG----VEGDLWVRGPSLTAGYWN------ Rv2048c|M.tuberculosis_H37Rv DVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRA MAV_2450|M.avium_104 DVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVVAREYPGVRYRA TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ----------------------------GYGQTAYSAANAFLDGLAWRLR Mvan_0269|M.vanbaalenii_PYR-1 ----------------------------GYGQTAYGAANAFLDGLAWRLR Mflv_0405|M.gilvum_PYR-GCK ----------------------------GFGQAAYGAANAFLDGLAWRLR MSMEG_0408|M.smegmatis_MC2_155 ----------------------------GFGQTAYGAANAFLDGLAWRLR Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -----------------------------RPTQPPSISDSWLDTRDRVCV Rv2048c|M.tuberculosis_H37Rv FDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQA MAV_2450|M.avium_104 FDLFEPGRPRMRQWMVELAGLFDAGVLNPLPVTTFDIRRGRAALRYLSQA TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EQGIAGTSVNFGPWSAGMADAESRARLEQRGIKTLSPTDALAGLADVVAA Mvan_0269|M.vanbaalenii_PYR-1 EQGISGVSINFGPWSAGMADAESRARLDQRGVRTLSPADALAGLADVVTA Mflv_0405|M.gilvum_PYR-GCK EQGVAGVSVNFGPWSAGMADAQSRARLEQRGIKTLSPADALAGLSDAVIS MSMEG_0408|M.smegmatis_MC2_155 ERGVTAVSVNFGPWAAGMADAESRARLEQRGVRTLSPAEALAGMADVVAG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M DAHGWVTYRCR----ADDIEIVGGININPREIEQLIVEDHLVAETAVVAV Rv2048c|M.tuberculosis_H37Rv RHTGKVVMLMPGSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSR MAV_2450|M.avium_104 RHIGKVVMTVPGALSAGTVLITGGTGMAGSTLARHLVTGHGVRDLALLSR TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SGS-NAVQGVIARIDWARFLPLYQQAGKRGFLAELDREVPSHLAGV--AG Mvan_0269|M.vanbaalenii_PYR-1 AEAPGPAQGIVARIDWERFLPLYQQAGRRAFLAELEREVPDTAP----AA Mflv_0405|M.gilvum_PYR-GCK AAP----HPVVARVDWSRFLPLYQQAGRRGFLAELERELPAAPAQQGPAV MSMEG_0408|M.smegmatis_MC2_155 PVQ-----GVVAKIDWSRFLPLYQQAGRRAFLSELESELPAAATGAAAPA Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M REATG-------------------------ESALQAFLVPESGASLGESA Rv2048c|M.tuberculosis_H37Rv RGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSG MAV_2450|M.avium_104 TGPDAPGAAEFVAELEAAGARVQVIACDAADRAALAGVIAGISAERPLSG TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAEVTRVDVSEIREDAGFF Mvan_0269|M.vanbaalenii_PYR-1 TPSGRTELVERLTNAPVQQRKKLLTDYLRTAVAEITRVDATEIREDAGFF Mflv_0405|M.gilvum_PYR-GCK TASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAEVTRVDAAEIREDAGFF MSMEG_0408|M.smegmatis_MC2_155 TVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAEVTRVDADEIRDEAGFF Mb2971c|M.bovis_AF2122/97 ------------------------------------------------MI MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M IKELHRRLLGSLSPHKVPHRFEIAERLPRTASGKLQRGQLRTQPAAQPVW Rv2048c|M.tuberculosis_H37Rv VIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF MAV_2450|M.avium_104 VIHAAGVLDDAMITSLTPERIDAVLRAKVDAAWNLHELTRDMNLSAFVMF TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DLGMDSLMAVELRRRMEQGVGKEIP------------------------- Mvan_0269|M.vanbaalenii_PYR-1 DLGMDSLMAVELRRRIEQGVGREIP------------------------- Mflv_0405|M.gilvum_PYR-GCK DLGMDSLMAVELRRRIETGVGKEIP------------------------- MSMEG_0408|M.smegmatis_MC2_155 DLGMDSLMAVELRRRIEQGVGKDIP------------------------- Mb2971c|M.bovis_AF2122/97 EEQRTMSVEGADQQSEKLFHYLKKV------------------------- MLBr_00135|M.leprae_Br4923 ---MTASVEGADQKSEKLISYLKKV------------------------- MUL_2005|M.ulcerans_Agy99 ---MTTSGESADQQNDKLFRYLKKV------------------------- MMAR_0101|M.marinum_M ERRCTVGTSDSDGQRDPQTQTNYKVGPR---------------------- Rv2048c|M.tuberculosis_H37Rv SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAM MAV_2450|M.avium_104 SSMAGLVGSSGQGNYAAANSFLDALAAHRRAHGLPAISLAWGLWDQASAM TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv TGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL MAV_2450|M.avium_104 TGGLDAADLARLGRDGILALSSDEAMELFDTALIVDEPFLAPARIDLGAL TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ---------------------------------VTLVMDHPRISDVADYL Mvan_0269|M.vanbaalenii_PYR-1 ---------------------------------ATLAMDHPRLSDVADYL Mflv_0405|M.gilvum_PYR-GCK ---------------------------------VTLVMDHPRLSDAADYL MSMEG_0408|M.smegmatis_MC2_155 ---------------------------------VTLVMDHPRLSDAADYL Mb2971c|M.bovis_AF2122/97 --------------------------------AVELDETRARLREYEQR- MLBr_00135|M.leprae_Br4923 --------------------------------VVELDETRARLREYEQR- MUL_2005|M.ulcerans_Agy99 --------------------------------AVELDEARARLREYEQR- MMAR_0101|M.marinum_M ------------------------------VGPVTLDERLAVLQQEGHRL Rv2048c|M.tuberculosis_H37Rv RAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQHA MAV_2450|M.avium_104 RAHAVAVPPMFADLVNAPTRRRVDDSLAAAKSKSALAHRLDGLPEAEQHA TH_2454|M.thermoresistible__bu ---------------------------------MSVDVTAKARPD----- : : MAB_0939|M.abscessus_ATCC_1997 LGDVLG-------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 LGEVLG-------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LGDVLG-------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 LVEVLG-------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M IADTVS-AEVAQILGDPAAERIDRDVAFAELGFDSRMTVELRNRLAAVTG Rv2048c|M.tuberculosis_H37Rv VLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATG MAV_2450|M.avium_104 VLLELVRSHIATVLGSPTAEAIDPDKAFQELGFDSLTAVEMRNRLKTATG TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ---------------------LAEQA--KPAAQLASAVTGRTDEPIAIVA Mvan_0269|M.vanbaalenii_PYR-1 ---------------------LAEQAPAKAGSQPASAAANRTDEPIAIVA Mflv_0405|M.gilvum_PYR-GCK ---------------------LTEAA---TAPKAATVVSTAADEPIAIVA MSMEG_0408|M.smegmatis_MC2_155 ---------------------LGEQT----NVRQASTVTARTDDPIAVVA Mb2971c|M.bovis_AF2122/97 -----------------------------------------ATEPVAVVG MLBr_00135|M.leprae_Br4923 -----------------------------------------ATEPVAVVG MUL_2005|M.ulcerans_Agy99 -----------------------------------------ATEPVAVVG MMAR_0101|M.marinum_M LRLPETVGWDYGSISRLAAHLETELAGSGGRGKPGPSV--AGGAPVAIVG Rv2048c|M.tuberculosis_H37Rv LSLSPTLIFDYPTPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVG MAV_2450|M.avium_104 LALSPTLIFDYPTPNALAGYIRTELAGAPQETTHAPVVRATDDDPIAIVG TH_2454|M.thermoresistible__bu -------------------------------------------DPIAIIG *:*::. MAB_0939|M.abscessus_ATCC_1997 VSCRFPG-APDPEAFWDVLSGGVDAIREVPEDR-FDIDEFYDPDPEVAGK Mvan_0269|M.vanbaalenii_PYR-1 VSCRFPG-APDPEAFWEVLAGGVDAIREVPEDR-FDIDEFYDPDPDAAGK Mflv_0405|M.gilvum_PYR-GCK VSCRFPG-APNPEAFWDLLSGGVDAIREVPEDR-FDIDEFYDPDPDAAGK MSMEG_0408|M.smegmatis_MC2_155 VSCRFPG-APDPESFWELLAGGVDAIREVPEDR-WDIDEFYDPDPDTPGK Mb2971c|M.bovis_AF2122/97 IGCRFPGGVDGPDGLWDVVSAGRDVVSEFPTDRGWDVEGLYDPDPDAEGK MLBr_00135|M.leprae_Br4923 IGCRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGK MUL_2005|M.ulcerans_Agy99 IGCRFPGGADGPEGLWDLVSQGRDAVTEFPNDRGWDTEGLFDPDPDAEGK MMAR_0101|M.marinum_M VGCRYPGGVESAGGLWDVVVGGRDVISGFPVDRGWDVEGVFDPDPDALGK Rv2048c|M.tuberculosis_H37Rv MACRYPGGVNSPDDMWDMLIQGRDVLSEFPADRGWDLAGLYNPDPDAAGA MAV_2450|M.avium_104 MSCRFPGGVDSPEALWQMVAEGRDVLSEFPTDRGWDLAGVYNPDPDVPGT TH_2454|M.thermoresistible__bu IGCRLAGRITSPEEFWGFLLAGGSNVREIPAER-WEPYLRRDPRNAAVLR :.** .* .. :* .: . : .* :* :: :* . MAB_0939|M.abscessus_ATCC_1997 TYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGY Mvan_0269|M.vanbaalenii_PYR-1 TYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGL Mflv_0405|M.gilvum_PYR-GCK TYTRYGGFLDHIDEFDPEFFGLSPREAVWIEPQQRLMLETVWEGLERAGY MSMEG_0408|M.smegmatis_MC2_155 TYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGY Mb2971c|M.bovis_AF2122/97 TYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEHAGI MLBr_00135|M.leprae_Br4923 TYTRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGI MUL_2005|M.ulcerans_Agy99 TYTRWGAFVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSWEALEHAGI MMAR_0101|M.marinum_M TYCRLGGFLDGADRFDAGFFGIGPSEALAMDPQQRLLLECSWEALEDAGI Rv2048c|M.tuberculosis_H37Rv CYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLELSWEALERAGI MAV_2450|M.avium_104 CYTRTGGFVDNVADFDPAFFGIAPSEALAMDPQQRMFLELSWEALERAGI TH_2454|M.thermoresistible__bu EITPWGTFLDDLAGFDAEFFGVSPREAELTDPQQRLALEVSWEALEHAGV * *:: **. ***: * *. :**:*: ** **.** ** MAB_0939|M.abscessus_ATCC_1997 SPAALRGSRTGIFAGVGANEYAHLLSSESIDKIEPYFITGNALNAISGRV Mvan_0269|M.vanbaalenii_PYR-1 APADLRGSRTGIFVGVAANEYAHLLSSESIEKIEPHFITGNALNAISGRV Mflv_0405|M.gilvum_PYR-GCK APSALRGSRTGVFVGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRV MSMEG_0408|M.smegmatis_MC2_155 APSDLRGSRTGVFTGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRV Mb2971c|M.bovis_AF2122/97 DPLSLRGSATGVYTGIFAASYGN----RDTGGLQGYGLTGTSISVASGRV MLBr_00135|M.leprae_Br4923 DPLSLRGSATGVFTGIFAPSYGS----RDTGGLQGYGLTGTAVSVASGRV MUL_2005|M.ulcerans_Agy99 DPMSLRGSSTGVFTGIFAPSYGG----KDVGALQGYGLTGSPVSVASGRV MMAR_0101|M.marinum_M DPVSLRGSVTGVFTGLMSSDYGAG---RVSGDLEGYGLTSAAASVASGRV Rv2048c|M.tuberculosis_H37Rv DPTGLRGSATGVFAGVMTQGYGM----FAAEPVEGFRLTGQLSSVASGRV MAV_2450|M.avium_104 DPVKLRGSATGMFAGVYTQGYGM----GAAPIAEGFRLTGQSSSVASGRV TH_2454|M.thermoresistible__bu PPRSLAGTDTAVLMGVNSDDYGRLLM-EDLPGIEAWTGIGTSLCGIANRV * * *: *.: *: : *. : . :.** MAB_0939|M.abscessus_ATCC_1997 AFALGFEGPAVAVDTACSSALVAVHQAVQALHSGDCDLALAGGVNVLLSP Mvan_0269|M.vanbaalenii_PYR-1 AFALGLEGPAVAVDTACSSALVAVHQACQALHSGDCDLALAGGVNVLLSP Mflv_0405|M.gilvum_PYR-GCK AFALGLEGPAVAVDTACSSSLVAVHQATQALRSGDCDMALAGGVNVLLSP MSMEG_0408|M.smegmatis_MC2_155 AFALGFEGPAVAVDTACSSALVAVHQACQALQSGDCDLALAGGVNVLLSP Mb2971c|M.bovis_AF2122/97 SYVLGLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLP MLBr_00135|M.leprae_Br4923 SYVLGLEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLP MUL_2005|M.ulcerans_Agy99 AYVLGLEGPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMGLP MMAR_0101|M.marinum_M AYLLGLEGPAVSVDTACSSSLVALHLAASSLRSGECDVALAGGVTVMATP Rv2048c|M.tuberculosis_H37Rv AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATP MAV_2450|M.avium_104 SYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGVTVNATP TH_2454|M.thermoresistible__bu SHLLDLRGPSVALDAACAASLVAVHNACQLLRAGETGLAIAGGVSALIGP :. *.:.**::::*:**:::***:* * *::*: .:*:****.. * MAB_0939|M.abscessus_ATCC_1997 VTVIAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAERDGD Mvan_0269|M.vanbaalenii_PYR-1 VTSVAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLGDAVRDGD Mflv_0405|M.gilvum_PYR-GCK VTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAVRDGD MSMEG_0408|M.smegmatis_MC2_155 VTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGD Mb2971c|M.bovis_AF2122/97 SIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRLGH MLBr_00135|M.leprae_Br4923 SIFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGH MUL_2005|M.ulcerans_Agy99 SIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRNGH MMAR_0101|M.marinum_M ATFVGFSRQRGLAADGRCKAFAGAADGTGFSEGAGVVVLMRLSEARRRGL Rv2048c|M.tuberculosis_H37Rv DIFVEFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGH MAV_2450|M.avium_104 DIFVEFSRMRGLSVDGRCKAYAGAADGTGFSEGGGMLVVERLSDARRLGH TH_2454|M.thermoresistible__bu GLTRVLDKAGATAPDGRCKSFDASADGYGRGEGAAVVILKRLPDALRDGD .: : ****:: :*** .** .:::: ** :* * * MAB_0939|M.abscessus_ATCC_1997 RVLAVIPGSAVNQDGASSGLTVPNGGAQQRLIGSVLARAGLVGGDVDYLE Mvan_0269|M.vanbaalenii_PYR-1 RVCAVIPSSAVNQDGASSGLTVPNGGAQQRLIGMALARAGLSGGDVDYLE Mflv_0405|M.gilvum_PYR-GCK RVCAVIAGSAVNQDGASSGLTVPNGGAQQRLIGTVLARAGITGGEVDYLE MSMEG_0408|M.smegmatis_MC2_155 RVCAVIPASSVNQDGASSGLTVPNGGAQQRLIEATLARAGLSGADVDYLE Mb2971c|M.bovis_AF2122/97 SVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALANAGLSAADVDVVE MLBr_00135|M.leprae_Br4923 TVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDVVE MUL_2005|M.ulcerans_Agy99 NVLAVVRGSAINQDGASNGLTAPNGLTQQRVIQAALANCGLTSADVDVVE MMAR_0101|M.marinum_M AVLGVIAGSAVNQDGASNGLTAPNGPAQQRVIEAALANAGLTAADVDVVE Rv2048c|M.tuberculosis_H37Rv PVLAVVVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVE MAV_2450|M.avium_104 PVLAVVRGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVE TH_2454|M.thermoresistible__bu RVIAVIRGGAVAQDGRTVGIMSPNGAAQRDLFRHTCEITGTSPATVDFVE * .*: ..:: *** : *: *** :*: :. . * . ** :* MAB_0939|M.abscessus_ATCC_1997 AHGTGTPLGDPIEVQAAAAAYGGSRDAD-RPLLMGSVKSNIGHTESASGA Mvan_0269|M.vanbaalenii_PYR-1 AHGTGTPLGDPIEVQAAAAAYGASRDAD-RPLLMGSVKTNIGHLESASGA Mflv_0405|M.gilvum_PYR-GCK AHGTGTPLGDPIEVQAAAAAYAGARDAD-RPLLMGSVKTNIGHTESASGA MSMEG_0408|M.smegmatis_MC2_155 AHGTGTPLGDPIEVQAAAAAYGAGRDAD-RPLLMGSVKTNIGHTESASGA Mb2971c|M.bovis_AF2122/97 AHGTATTLGDPIEAQALLSTYGQGRPAE-QPLWVGSIKSNMGHTQAAAGV MLBr_00135|M.leprae_Br4923 AHGTATTLGDPIEAQALLATYGQGRPAD-QPLWVGSIKSNMGHTQAAAGV MUL_2005|M.ulcerans_Agy99 AHGTATTLGDPIEAEALLATYGQGRPTD-QPLWVGSIKSNMGHTQAAAGV MMAR_0101|M.marinum_M GHGTGTTLGDPIEAQALLATYGQARPAD-QPLWLGSIKSNMGHTQAAAGI Rv2048c|M.tuberculosis_H37Rv GHGTGTTLGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGV MAV_2450|M.avium_104 GHGTGTTLGDPIEAQALLATYGQDRGQP---LWLGSIKSNMGHTQAAAGV TH_2454|M.thermoresistible__bu AHGTGTPTGDPVELDALAAVYGAAHGPD-DPCRVGSVKPNTGHLEGGAGV .***.*. ***:* :* :.*. : :**:*.* ** :..:* MAB_0939|M.abscessus_ATCC_1997 AGLIKVVLSLQNGVLPQSLHFDNPSPHIPWESLPVRVVDKAIPWQ-ANGR Mvan_0269|M.vanbaalenii_PYR-1 AGLIKVVLSLQHNLLPQSLHFENPSPHIPWDSLPVRVVDKAIPWQ-ADGR Mflv_0405|M.gilvum_PYR-GCK AGLIKVVLSLQHETLPQSLHFDTPSPHIPWDSLPVRVVDTAMPWQ-PNGR MSMEG_0408|M.smegmatis_MC2_155 AGLIKVVLSLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQ-TNGR Mb2971c|M.bovis_AF2122/97 AGVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREWS-VDGR MLBr_00135|M.leprae_Br4923 AGVIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWS-VEGR MUL_2005|M.ulcerans_Agy99 AGVIKMVQAMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDWP-DAGR MMAR_0101|M.marinum_M AGVIKMVQAMRHELMPATLHVDVPSPHVDWSSGAVSLLTQPRPWPAVDGR Rv2048c|M.tuberculosis_H37Rv AGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP-AGAR MAV_2450|M.avium_104 AGVIKMVLAMRHELLPATLHVDEPSPHVDWSAGAVSLLTEAQPWP-G-ER TH_2454|M.thermoresistible__bu VGLIKAALALQHGVIPPTAGIRELTPAVDWATNGLHVPTTVEPFPRRADS .*:** . :::: :* : . : : * : : : : MAB_0939|M.abscessus_ATCC_1997 PRRAGVSSFGFTGTNAHVLIEEAPQPQATP----------DEDDASTPQS Mvan_0269|M.vanbaalenii_PYR-1 PRRAGVSSFGFTGTNAHVLIEEAPLPQAAD----------PVEEPDT-RA Mflv_0405|M.gilvum_PYR-GCK PRRAGVSSFGFTGTNAHVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAP MSMEG_0408|M.smegmatis_MC2_155 VRRAGVSSFGFTGTNAHVLVEEAPPQLHTADAAP----VEPAATAEAGTD Mb2971c|M.bovis_AF2122/97 PRRAAVSSFGISGTNAHLILEEAPVPAPA------EAPVEASESTGGP-R MLBr_00135|M.leprae_Br4923 PRRAGVSSFGISGTNAHVILEEAPT------------PVEASYSTADQQR MUL_2005|M.ulcerans_Agy99 PRRAGVSSFGISGTNAHVILEEAPAP----------EAVPDSESNKGEPS MMAR_0101|M.marinum_M PRRAGVSSFGISGTNAHVIVEQVCP---------------EVVAEAVDVS Rv2048c|M.tuberculosis_H37Rv TRRAGVSSFGISGTNAHVIIEAVP----------------VVPRREAGWA MAV_2450|M.avium_104 PRRAGVSSFGISGTNAHVIIEAVPA---------------VEPAHADAPA TH_2454|M.thermoresistible__bu PRRAAVCSYGYGGTIAHLLLEEAPAVDETP-----AAAPAPAADAADANS ***.*.*:* ** **:::* . MAB_0939|M.abscessus_ATCC_1997 APVSVLPLSARSPEALAAVAQRYESWLAAHPDVDLEDVCLTAGRGRSHFE Mvan_0269|M.vanbaalenii_PYR-1 LPVGVLALSARSPEALTALAQRYEAWLSAHPDADLADVCRTAGTGRSHFE Mflv_0405|M.gilvum_PYR-GCK APVEVLPLSARSPEALVALAQRYETWLTAHPEADLADVCRTAGTGRSHFE MSMEG_0408|M.smegmatis_MC2_155 DSPQVLALSARSPEALVELARRYDDWLSATPGLDIADVCHTAGVGRSHFE Mb2971c|M.bovis_AF2122/97 PSMVPWVISARSAEALTAQAGRLMAHVQANPGLDPIDVG-CSLASRSVFE MLBr_00135|M.leprae_Br4923 LSVVPWVVSGRSTAALMAQASRLAFYVQADPEVDPVDVG-CALAARSVFE MUL_2005|M.ulcerans_Agy99 LPVVPWVISARSAEALTAQAGRLLAHVQADPQSNPVDIG-FSLAGRSAFE MMAR_0101|M.marinum_M PDSLPWVVSGKSEAAVAAQAKRLLAAVQADEGLDRLDVG-FSLARRTAFE Rv2048c|M.tuberculosis_H37Rv GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVG-WSLAGRSVFE MAV_2450|M.avium_104 LPVLPWVVSAKSAAALRAQAARLAEYVRAQGELDIADVG-WTLAGRATFE TH_2454|M.thermoresistible__bu PRFHVIPVSARSGARLARHAAALRGHLSAGADLTAVAAT-MWQR-RSHEP :*.:* : * : . *: MAB_0939|M.abscessus_ATCC_1997 HRAALVVDSIQTAREGLLELAQNRLRPGVVRGEHTNHPTT--AWLFTGQG Mvan_0269|M.vanbaalenii_PYR-1 HRAALVVDSVAAAREGLAELAQNRLRPGVVRGEHTHHPTT--AWLFTGQG Mflv_0405|M.gilvum_PYR-GCK HRAALVVDSVESARIALTDLAQNRLRPGVVRGEHLNHPTT--AWMFTGQG MSMEG_0408|M.smegmatis_MC2_155 YRAALVVDSVERAREGLAALAEGRTPAGVVRGEHVHRPTT--AWLFTGQG Mb2971c|M.bovis_AF2122/97 HRAVVVGASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKT--VVVFPGQG MLBr_00135|M.leprae_Br4923 HRAVVVGESREQLIAGLAGLAVGESGAGVAIGQAAPLGKT--VVVFPGQG MUL_2005|M.ulcerans_Agy99 HRAVVVGADRQQLLTGLATLADGAPGAGVVTGQAGSVGKT--AVVFPGQG MMAR_0101|M.marinum_M YRAVVLGEDRQQLISGLTELAAGQPGPTVLNGRAATVSKT--VMVFPGQG Rv2048c|M.tuberculosis_H37Rv HRAVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKT--VFVFPGQG MAV_2450|M.avium_104 HRAVVVGGDRDRLLAGLDELAADDPAASIIRGVATPAGKT--VFVFPGQG TH_2454|M.thermoresistible__bu VRAAVIARHPGELVAGLDAIATDTRHPAVVAGSVLPAAEAGAVWVFSGHG **.:: .* :* . : * : . :*.*:* MAB_0939|M.abscessus_ATCC_1997 SQYPGMARELFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGK Mvan_0269|M.vanbaalenii_PYR-1 SQFPGMARELFETEPVFADAVTRCADAVKDILPRPLLEVLFAADRESG-- Mflv_0405|M.gilvum_PYR-GCK SQYPGMARELFDTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVP MSMEG_0408|M.smegmatis_MC2_155 SQYPGMARELFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRETA-- Mb2971c|M.bovis_AF2122/97 AQRIGMGRELYGELPVFAQAFDAVADELDRHLRLPLRDVIWGADA----- MLBr_00135|M.leprae_Br4923 AQRIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGADA----- MUL_2005|M.ulcerans_Agy99 SQRIGMARELHDQLPVFAEAFDAVADELDRHLRIPLCEVMWGSDV----- MMAR_0101|M.marinum_M SQRLGMGQQLHGQFPVFAQAFDAVVEQLDRYLRLPLRDALWGGDE----- Rv2048c|M.tuberculosis_H37Rv SQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGHDE----- MAV_2450|M.avium_104 SQTLGMGRQLHAGYPVFAEAFDAVVAELDRHLLRPLRDVIWGDDE----- TH_2454|M.thermoresistible__bu SHWPGMGRELLEHEPVFAAVIDEIEPVFRAELGFSPRQALQSGE------ :: **. * **** . . : . :.: . MAB_0939|M.abscessus_ATCC_1997 AGEALRHTSFAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVA Mvan_0269|M.vanbaalenii_PYR-1 --EALRHTSFAQPAIFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVA Mflv_0405|M.gilvum_PYR-GCK PTETLRHTSFAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVA MSMEG_0408|M.smegmatis_MC2_155 --DLLQHTSFAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVA Mb2971c|M.bovis_AF2122/97 --DLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAA MLBr_00135|M.leprae_Br4923 --GLLDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVA MUL_2005|M.ulcerans_Agy99 --ALLDSTEFAQAALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVA MMAR_0101|M.marinum_M --HLLESTEFAQPSLFAVEVALFALLRDWGVSPDVVMGHSVGELSAAHVA Rv2048c|M.tuberculosis_H37Rv --NLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVA MAV_2450|M.avium_104 --NVLNSTEFAQPALFAVEVALFRLLESWGVRPDFVMGHSIGELSAAHVA TH_2454|M.thermoresistible__bu ----LGGTDRVQALTFAVQAGLAAVLRDRGVKPAAVIGHSVGEVAACVAA * *. .*. ***: . .: * *:***:*: :*. .* MAB_0939|M.abscessus_ATCC_1997 GVFSIEDGARLIAERGRLFGGLPAGGRMVAVFSDAKHVEQIAGEFPRVSV Mvan_0269|M.vanbaalenii_PYR-1 GVFSLEDGARLMAERGRMFGSLPEGGRMVAVFTDAKLVEEIAGDFPRVSV Mflv_0405|M.gilvum_PYR-GCK GVFSLEDGARLMAERGRLFGSLPEGGRMVAVFADAKRVEQVAADFPRVSV MSMEG_0408|M.smegmatis_MC2_155 GVFSLDDGARLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEFPRVSV Mb2971c|M.bovis_AF2122/97 GVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAA MLBr_00135|M.leprae_Br4923 GVLAPADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEGVGIAA MUL_2005|M.ulcerans_Agy99 GVLTLVDAAMLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDGVGIAA MMAR_0101|M.marinum_M GVLTLDDAAKLVAARGRLMQALPEGGAMFAIAASEHEVSPLLGEAVGIAA Rv2048c|M.tuberculosis_H37Rv GVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAA MAV_2450|M.avium_104 GVLSLQNAAVLVAARGRFMQALPEGGAMIAVQATEAQVRPLLGPDVGIAA TH_2454|M.thermoresistible__bu GVFDLARGAAVACYRARGFRSVAGKGAMALVGLPFEDARQRLGERTDVVA **: .* : *.* : .:. * * : . : . MAB_0939|M.abscessus_ATCC_1997 GAY-NGPNTVLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDPIL Mvan_0269|M.vanbaalenii_PYR-1 GAY-NGPNTVLSGPGEDLEQIVDRFGDDGVRCTWLQTSHAFHSELLDPVL Mflv_0405|M.gilvum_PYR-GCK GAY-NGPNTVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVL MSMEG_0408|M.smegmatis_MC2_155 GAY-NGPNTVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVL Mb2971c|M.bovis_AF2122/97 IN--APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPML MLBr_00135|M.leprae_Br4923 IN--APESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPML MUL_2005|M.ulcerans_Agy99 IN--APKSVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPML MMAR_0101|M.marinum_M IN--APDAVVISGERAAVGVLAEELIDRGRRVHRLAVSHAFHSPLMEPML Rv2048c|M.tuberculosis_H37Rv VN--GPASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMI MAV_2450|M.avium_104 VN--GPAAVVISGDHDAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMI TH_2454|M.thermoresistible__bu AISASPLSTVISGTVDAVGEVSAAWAEQGVMVRKVNTDVAFHSPAMDALT *:** * : .. **** ::.: MAB_0939|M.abscessus_ATCC_1997 DEFESYAAQVQFAAPTLPLVCNRTGAVLTAQT-PIDGQYWRRHSRQPVQF Mvan_0269|M.vanbaalenii_PYR-1 DEFESYAAQFQFATPTLPLVCNRTGTVLTAQT-PLDAQYWRRHSRQPVQF Mflv_0405|M.gilvum_PYR-GCK DEFESYAAQLQFAAPTLPLVCNRTGAVLTGQT-SLDAQYWRRHSRQPVQF MSMEG_0408|M.smegmatis_MC2_155 DEFEAYAAQFQFAAPTLPLVCNRTGAVLTGQT-PLDAQYWRRHSRQPVQF Mb2971c|M.bovis_AF2122/97 EEFARVAARVQAREPQLGLVSNVTGELAGPD--FGSAQYWVDHVRRPVRF MLBr_00135|M.leprae_Br4923 EEFVRVAAQVEVRKPQIGLVSNVTGELAGPD--FGSPQYWGEHVSRAVRF MUL_2005|M.ulcerans_Agy99 EEFARIAAQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAVRF MMAR_0101|M.marinum_M ADFALAAGDITAHPPRIALVSNLTGELAGPD--YGSAQYWVEHVRRPVRF Rv2048c|M.tuberculosis_H37Rv DEFAAVAAGIAIGRPTIGVISNVTGQLAGDD--FGSAAYWRRHIRQAVRF MAV_2450|M.avium_104 DEFGTVAAGLAIDKPVIPIISNLTGQPAADD--FGSPEYWKCHVRDAVRF TH_2454|M.thermoresistible__bu AELARLTSTLTPKPAAVPLYSTALADPRSTA--ARDEHYWVANLRGRVRF :: :. . . : : .. . . ** : *:* MAB_0939|M.abscessus_ATCC_1997 AESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAPP-RAIVSLRKGV Mvan_0269|M.vanbaalenii_PYR-1 AESVRTVAALGCSVLMEIGPQPVLTGSAVQVWPEHLAAP-RAIVSLRKGV Mflv_0405|M.gilvum_PYR-GCK AESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAAP-RAIASLRKGV MSMEG_0408|M.smegmatis_MC2_155 AESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHMAAP-RAVASLRKGV Mb2971c|M.bovis_AF2122/97 ADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAPAEA---MVVSMLGKDR MLBr_00135|M.leprae_Br4923 VDSARHLQTLGATHFIESGPSSGLMGAIEQSLAPAEA---VVVSMMGKDR MUL_2005|M.ulcerans_Agy99 ADSARQLHTLGVTHFVEVGPGSGLTGSIEQSLAPAEA---VVVSMLGKDR MMAR_0101|M.marinum_M ADSVRNLEELGASHFIEVGPGGGLSSAIAQSLRSPEA---VTVPVLGKDR Rv2048c|M.tuberculosis_H37Rv ADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAV---TTMSALRKDR MAV_2450|M.avium_104 ADSVRFAQSAGATRFLEVGPSSGLTAAIEETLADAPV---VTVSALRKDR TH_2454|M.thermoresistible__bu AEAVTAAAEDGHRLFLEVSAHPVVCHSMAETLALAEVGEHAVLPVLRREQ .::. * ::* .. : : : . .: : : MAB_0939|M.abscessus_ATCC_1997 EDRRQIADALASAYVSGHRPNFAALQR-HPRRTVELPTYPFQRRRFWPK- Mvan_0269|M.vanbaalenii_PYR-1 SDRRQITEALAAAYVGGHRPDFGALYR-RPGRAVALPTYPFQRRRFWPK- Mflv_0405|M.gilvum_PYR-GCK ADRRQIADALAAAYIGGHKPDFAALHE-QRGVRLELPTYPFQRRRFWPK- MSMEG_0408|M.smegmatis_MC2_155 ADRRQIADALASAYVGGHRPDFAAVHR-QPRRPVELPTYPFQRRRFWPK- Mb2971c|M.bovis_AF2122/97 PELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETP MLBr_00135|M.leprae_Br4923 PELASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETP MUL_2005|M.ulcerans_Agy99 PEVASVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRRFWEVP MMAR_0101|M.marinum_M PEVNSLISAVGQLFSTGVGVDWSAVFAGSGGRQVGLPTYAFARRRFWLD- Rv2048c|M.tuberculosis_H37Rv PEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRFWLS- MAV_2450|M.avium_104 PEPVALVNAVAQGWVCGMDVDWRGALG--TGHLVDLPTYAFDRRRFWLS- TH_2454|M.thermoresistible__bu PELPAVAAVVGALYCHGAPVRP--AFPPGTRWATGLPGTQWQHRRFWRT- : . . : * ** : :**** MAB_0939|M.abscessus_ATCC_1997 --SSGTAIEGGGGLPSG--ILGRGED-LASGDSVYISRLSVRSQPWLSDH Mvan_0269|M.vanbaalenii_PYR-1 --TSGITTDG--PAVSG--ILGSAKD-LASGDTVYTSRWSVRSQPWLADH Mflv_0405|M.gilvum_PYR-GCK --SAGMAIDGRVGASAGSGILGSGKD-LASGDSVYTSRLSVKTQPWLSDH MSMEG_0408|M.smegmatis_MC2_155 --ASSIAVDGG-TAASG--ILGSGKD-LASGDTIYTSRLSVKSQPWLADH Mb2971c|M.bovis_AF2122/97 GADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADH MLBr_00135|M.leprae_Br4923 GTDGTASVSGLGLGSTEHALLGAVVERPDSGGVVLTGRLSLANQPWLADH MUL_2005|M.ulcerans_Agy99 GADGPADATGLGLGGAEHALLGAVVERPDSGGVVLTGRLALADQPWLADH MMAR_0101|M.marinum_M GSASAADVGEAGLVAAGHALLGAVVEQPDTGAVVLTGRLSLARQPWLADH Rv2048c|M.tuberculosis_H37Rv GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADH MAV_2450|M.avium_104 GDGAASDAAGLGLAAGDHALLGAVVELPASGGVLLTGRLSPASQGWLADH TH_2454|M.thermoresistible__bu -PGTPPGGVGVHDVDSHTLLGGRIDVAGAVPARVWQTRLDLSTRPYPGDH : * : * : : .** MAB_0939|M.abscessus_ATCC_1997 VIYGTVVVPGATYAAMALAAVG--------------------TPARAKDV Mvan_0269|M.vanbaalenii_PYR-1 VIYGTVVVPGATYAAMALAAVG--------------------TPARVKDV Mflv_0405|M.gilvum_PYR-GCK VIYGTVVVPGATYAAMALAAVG--------------------TPAHAKDV MSMEG_0408|M.smegmatis_MC2_155 VIYGTVVVPGATYAAMALAAVG--------------------TPARLKDV Mb2971c|M.bovis_AF2122/97 VVNGVVLFPGAGFVELVIRAG------------------DEVGCALIEEL MLBr_00135|M.leprae_Br4923 VIGGVVLFPGAGFVELVIRAG------------------DEVGCAGVEEL MUL_2005|M.ulcerans_Agy99 VIGGVVLFPGAGFVELAIRAG------------------DEVGCAVVEEL MMAR_0101|M.marinum_M LVGGAVLFPGTGFVELAIRAG------------------DEVGCGVVEEL Rv2048c|M.tuberculosis_H37Rv SVAGVTIFPGAGFVELAIRAG------------------DEVGCGVVDES MAV_2450|M.avium_104 AVGGVVLFPGAGFVELAIRAG------------------DEVGCGIIDEL TH_2454|M.thermoresistible__bu PVQGTEIVPAAVLLNTFLTAAGSDIADVRLRTPVAPARTRDVQVVLQDRA : *. :.*.: : * . MAB_0939|M.abscessus_ATCC_1997 FFYEPIILPEKSSREVQLTLHPLEDGSGSKFQVHSRPYGERDVDWSLNAE Mvan_0269|M.vanbaalenii_PYR-1 FFYEPIILPEKASREVQLTLHPSEDG-GQKFQVHSREYGERGTEWSLNAE Mflv_0405|M.gilvum_PYR-GCK FFYEPIILPEKSSREVQLTVHPSVDG-ESKFQVHSRPYGERGAEWALNAE MSMEG_0408|M.smegmatis_MC2_155 FFYEPIILPEKASREVQLTLHPADGGSVLSFQIHSRPYGERGADWSLNAE Mb2971c|M.bovis_AF2122/97 VLAAPLVMHPGVGVQVQVVVGAADESGHRAVSVYSRGD-QSQG-WLLNAE MLBr_00135|M.leprae_Br4923 VLAAPLVLHPGSGVQVQVVVAAADESSRRAVSVYSRGD-QSHGGWLLNAE MUL_2005|M.ulcerans_Agy99 VLAAPLVLHPGMGVQVQVIVGTADDSGNRALSVYSRGD-KSED-WLLNAE MMAR_0101|M.marinum_M TLATPLVLNAGTAVQVQVVVGSAGQSGQRLVSMYSRAD-QPDQHWVLHAQ Rv2048c|M.tuberculosis_H37Rv TLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRGD-VGTG-WVLHAE MAV_2450|M.avium_104 NLAAPLVLPAGGSVAIQVVVDGPDDSGARAVSVFSRAD-AGAG-WLLHAE TH_2454|M.thermoresistible__bu LALASRIVGEDTTARATAGRDTTDRDTTACDTTDRDTT-ACDDPGVWLTH . :: . :. MAB_0939|M.abscessus_ATCC_1997 GTVVTGIGDDAEPAPEAAEPAEPVDAAIERMERMRPMELFEIFADLELAW Mvan_0269|M.vanbaalenii_PYR-1 GTVASGVDENPQ-----AEPSGPVDEAIERLNRMRPQDLFETFADMELAW Mflv_0405|M.gilvum_PYR-GCK GVVASGVGDSPAAAG---DLEDPVDEAIERLNRMRPQELFETFADLELAW MSMEG_0408|M.smegmatis_MC2_155 GTVDTAGSDPDAAAD---EQSDPVDEVIERLERMRPQDLFETFADLELAW Mb2971c|M.bovis_AF2122/97 GMLG----VAAAETP-----MDLSVWPPEGAESVDISDGYAQLAERGYAY MLBr_00135|M.leprae_Br4923 GLLE----VDAAEAT-----VDLSLWPPEGAESVDISDAYPQLAERGYAY MUL_2005|M.ulcerans_Agy99 GMLG----VEAASSG-----ADLSVWPPEGAESVDISDGYAQLADRGYAY MMAR_0101|M.marinum_M GSVAPAAVQPAAAAS-----AELSTWPPAGAEAVDIGGLYERLARRGYGY Rv2048c|M.tuberculosis_H37Rv GALR----AGSAEPT-----ADLAMWPPAGAVPVEVADGYQQLAERGYGY MAV_2450|M.avium_104 GVLR----AGSAQPA-----TDLSAWPPVGAVPVDLGDGYEQLAERGYRY TH_2454|M.thermoresistible__bu CTARVADDHVGAEGV-----LDEEAIRARCPQPLPAGHVVDTLAGLGVAA : :* MAB_0939|M.abscessus_ATCC_1997 GPTWSGSLKSLWLGEGEAIGDVLVGEELAEQLGTEPMHPVLMDLCTGVAF Mvan_0269|M.vanbaalenii_PYR-1 GPTWSGSLKSLWLGEGEAIGDILVGEELAEQLGTEPMHPVLMDLCTGVAF Mflv_0405|M.gilvum_PYR-GCK GPTWSGSLKSLWLGEGEAIGDILVGAELAEQLGTEPMHPVLMDLCTGVAF MSMEG_0408|M.smegmatis_MC2_155 GPTWSGSLKSLWLGDGEAVGDILVGAELAEQLGSEPMHPVLMDLCTGVAF Mb2971c|M.bovis_AF2122/97 GPAFQG-LVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALG MLBr_00135|M.leprae_Br4923 GPAFQG-LVAIWRRGSELFAEVVAP--TGVVVDGMGMHPALLDAVLHALG MUL_2005|M.ulcerans_Agy99 GPGFQG-LVGVWRRDSELFAEVVAP--SGVAVDKMGMHPVVLDAVLHALG MMAR_0101|M.marinum_M GPAFQG-LRAVWRRGRDVFAEVGLPNDEGLDLTDVGIHPALLDAVLHATM Rv2048c|M.tuberculosis_H37Rv GPAFRG-LTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVV MAV_2450|M.avium_104 GPAFRG-LTSMWRRGDEIFAEVNLPTDAGVSTTGFGVHPVMLDAALHAVM TH_2454|M.thermoresistible__bu MGFGWE-VLELHRGEGELFARVAAE--------PDKSAPATWAGLIDAAT : : : .. : *. . MAB_0939|M.abscessus_ATCC_1997 PAFPALLAAEQGVNDLFLPLRYGQVTLKEKMPRRFYCRARWHESPLDSET Mvan_0269|M.vanbaalenii_PYR-1 PAFPALLAAEQGVSDLFLPLRYGQVTLRDKMPRRFYCRATWHTSELDSET Mflv_0405|M.gilvum_PYR-GCK PAFPALLAAEQGVNDLYLPLRYGQVSLQEKMPRRFYCRATWHEAPLDSET MSMEG_0408|M.smegmatis_MC2_155 PAFPALLAAEQGVNDLFLPLRYGQVTLAEKMPRRFYCRARWHRSALDSET Mb2971c|M.bovis_AF2122/97 ---LAVEKTQASTE-TRLPFCWRGVSLHAGGAGRVRARFASA-GAD--AI MLBr_00135|M.leprae_Br4923 ---LAIENTQATTE-MRLPFCWRGVSLHAGGAGRVRARFTSA-GAD--AI MUL_2005|M.ulcerans_Agy99 ---LTAEQNPDSDE-TKLPFCWRGVSLHAGGAGRVRARLTMS-GPD--SI MMAR_0101|M.marinum_M ---AAAG--ADVAE-MRLPFSWRGVSLHAAGAAGLRARIAALDGGDGAAV Rv2048c|M.tuberculosis_H37Rv ---LSAESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPS---AV MAV_2450|M.avium_104 ---LASDGDDLPAGSMLVPFSWQRVSLHAAGAAAVRARIVPVSPS---AV TH_2454|M.thermoresistible__bu ---STASTIFDGPPRLRMPARIERVHVRDKPPAIALLHVRRRPEGT--VT : :* * : . : MAB_0939|M.abscessus_ATCC_1997 QVFDLDYLDRDGRHLGGIREFTVKRAPREALLRGLGG-DATRLLYTLGWH Mvan_0269|M.vanbaalenii_PYR-1 QVFDLDFLDRDGRHLGGIREFTVKRAPREALLRGLGG-DATRLLYTLGWH Mflv_0405|M.gilvum_PYR-GCK QVFDLEYLDRDGRHLGGVREFTVKRAPREALLRGLGG-DATRLLYTLGWH MSMEG_0408|M.smegmatis_MC2_155 QVFELEFVDLGGRALGGIREFTVKRAPREALLRGLGG-DATRLLYTLGWH Mb2971c|M.bovis_AF2122/97 SVDVCDATGLPVLTVRSLVTRPITAEQLRAAVTAAGG-ASDQGPLEVVWS MLBr_00135|M.leprae_Br4923 AVDIADSAGLPVLTVRSLVTRAMTAEQLRTAVTAAGG-ALEQGPMDLVWS MUL_2005|M.ulcerans_Agy99 SVEIADAAGLPVLTVGALVTRAMSAAQLRAAVAEAGGGAPDQGPLDVIWS MMAR_0101|M.marinum_M SVELADAAGLPVLSVDSLVTRPVTANQLNAAIAAAAG-APDDKLLEVAWS Rv2048c|M.tuberculosis_H37Rv SIELADGLGLPVLSVASMLARPVTDQQLRAAVSSSGP----DRLFEVTWS MAV_2450|M.avium_104 SIELADGLGLPVLSVASMVARPVTDQQLLAAVSNSGP----DRLFELIWS TH_2454|M.thermoresistible__bu DVTIAEESGAVSVTLTGMGFEELENPGGGGSSGDLTGMLHHLRWHPVDWP : : . : .: : : * MAB_0939|M.abscessus_ATCC_1997 EVAVPPVAGEGEESAASIGTWLIAGFDELAAKVPGCIPLNRETDPELLGE Mvan_0269|M.vanbaalenii_PYR-1 EVPAPASG-----DAALNGNWLIAGFDELAAGVPGCIPFDRSTDPEPLGQ Mflv_0405|M.gilvum_PYR-GCK EVPVPESG----DGAAPQGTWLIGGFDELAVSVPGCIPADR-TNPESLRQ MSMEG_0408|M.smegmatis_MC2_155 EVPPPPSA------DDAVGTWLIAGFDELAAKVPGCVPIDRNTDLQVLGE Mb2971c|M.bovis_AF2122/97 PISVVSGG--------------ANGSAPPAPVSWADFCAGSDG------- MLBr_00135|M.leprae_Br4923 PIPLSSDG--------------HGG-GLPSVVSWADYCAGRGN------- MUL_2005|M.ulcerans_Agy99 PIPLSGSG--------------TNGSAQPAVVSWADFCAGGDGGAA---- MMAR_0101|M.marinum_M PIALNDRT--------------IGGRDDVPVMLWDDHRDDDGHG------ Rv2048c|M.tuberculosis_H37Rv PQPS-------------------AAVEPLPVCAWGTTEDSA--------- MAV_2450|M.avium_104 AQPS-------------------TAVQPVSLLNWGATELDATDTDSD--- TH_2454|M.thermoresistible__bu DTDPPAAV--------------VLVGGDARTRAFVTRDLDEARVAHRS-- . MAB_0939|M.abscessus_ATCC_1997 VLVAAKERGVPFSGVVWRAAGPGATES--TTESAARLEGEIAHLLSAVHT Mvan_0269|M.vanbaalenii_PYR-1 LLAQAHERGIGFSGVVWRAAAPSADES--STAMAARIETEIADLLSAVHT Mflv_0405|M.gilvum_PYR-GCK LLTDAHGRGLPFSGVVWRAARSDGDES--DAEVAARLEAEIAELLGAVHT MSMEG_0408|M.smegmatis_MC2_155 VLSQAHARGAGFSGVVWRCATPGRKESGSASAESARLEAEITNLLSAVHA Mb2971c|M.bovis_AF2122/97 -----------DASVVVWELESAGGQASS---VVGSVYAATHTALEVLQS MLBr_00135|M.leprae_Br4923 -----------DTGVVVWEFGSASAGAQAPVDSVAAVYSATHAALQVLQF MUL_2005|M.ulcerans_Agy99 ----------GDAGVVVWEPNPAG------EDVVGPVYAATHAALEVLQS MMAR_0101|M.marinum_M -----------AGTVVIWESCCAADD-----DVVRSAYAATHAALAVLQS Rv2048c|M.tuberculosis_H37Rv --------------AVVFESVPLAG------DVVAGVYAATSSVLDVLQS MAV_2450|M.avium_104 ----------SGRFAVLFESAPVAG------DVVTEVYAATRAVLPVLQS TH_2454|M.thermoresistible__bu ----------YADPAALPPDLTAGTVVLVLPRTAARPAASAQLVLHTLQR .. * .:: MAB_0939|M.abscessus_ATCC_1997 VQNSAQNGVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTTINEEP Mvan_0269|M.vanbaalenii_PYR-1 VQN---GAVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTTINEEP Mflv_0405|M.gilvum_PYR-GCK VQG---GEVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTAINEEP MSMEG_0408|M.smegmatis_MC2_155 AQG---PSVKLPGGLWIVTEHGVACESGEPVDPVQAALWGFGRTTINEEP Mb2971c|M.bovis_AF2122/97 WLG-----ADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENP MLBr_00135|M.leprae_Br4923 WFG-----QDRAGTLVVLTRGAVGLVGEGISDLAAAAVWGMVRSAQSEHS MUL_2005|M.ulcerans_Agy99 WFD-----GDRAGTLVVLTHGAVAMPGENVSDLAGAAVWGIVRSAQAENP MMAR_0101|M.marinum_M WLS-----GDRPGTLVIVTHGGVALTDEGVKDLAAAAVWGLVRSAQSEHP Rv2048c|M.tuberculosis_H37Rv WLT-----RDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHP MAV_2450|M.avium_104 WLA-----RDGAGTLVVSTRGAMTLPGEDVTDLAGAAVWGLVRSAQTEHP TH_2454|M.thermoresistible__bu LSA-----TNSGARLWVLTRGVHEG-----TDPGHGPLWGLARVAAAEHP . . * : *. * ..:**: * : *.. MAB_0939|M.abscessus_ATCC_1997 ALRAKLVDGDGSPEAVQALARLLVTP-VDEPEIAVRQGKLLASRLLPWSR Mvan_0269|M.vanbaalenii_PYR-1 ALRCRLVDVDGSPEAVLALAGLLAAP-VDEPELAVRQGKLLASRLLPWAR Mflv_0405|M.gilvum_PYR-GCK ALRCRLVDCDGSPQAVQALAALLSTP-VDEPELAVRQGKLLASRLLPWSR MSMEG_0408|M.smegmatis_MC2_155 ALHCRLVDCDGSSEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLLPWAR Mb2971c|M.bovis_AF2122/97 GR-IVLIDTDAA-------VDASVLAGVGEPQLLVRGGTVHAPRLS--PA MLBr_00135|M.leprae_Br4923 GK-IVLIDTDSA-------VDVAVLADLGESQLLVRCNTVHAARLS--PA MUL_2005|M.ulcerans_Agy99 GR-IVLVDADAA-------VEAAELVAVGEPQLVVRSGAAHAARLA--PA MMAR_0101|M.marinum_M GR-IVLIDTDSAPTDPEVLMDLANLAGRGEPQLLVSGGAVYGARLA--PI Rv2048c|M.tuberculosis_H37Rv GR-IVLVDSDAP----LDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRA MAV_2450|M.avium_104 GR-IVLVDTDAP----LDADAVAAVLAVGEPQTLLRNGTVYTARVLGSRA TH_2454|M.thermoresistible__bu QL-WGGLLDIGE----DRLPVRALTALTGHGVVVVRDGVAHTARLA--PA : . . . .*: MAB_0939|M.abscessus_ATCC_1997 TGHLTVPRGSDYVLAPTERGAIDN---LRITEKEVPAPDEGYVQVRVEAA Mvan_0269|M.vanbaalenii_PYR-1 SGHLTVPRSADYVLAPTERGAIDN---LRLTETDVAPPAEGYVQVRVEAA Mflv_0405|M.gilvum_PYR-GCK SGHLTVPRGGDYVLAPTERGAIDN---LRLTDSEVPPPAEGYVQVRVEAA MSMEG_0408|M.smegmatis_MC2_155 SGHLTLPRGGDFVLAPTERGAIDN---LRLTETDVPEPDEGYVQVRVEAA Mb2971c|M.bovis_AF2122/97 PALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAV MLBr_00135|M.leprae_Br4923 PQLLALPVGESMWRLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAV MUL_2005|M.ulcerans_Agy99 APLLAVPADESAWRLAAGGGGTLEDLVIEPCPEVQAPLAAGQVRVAVRAV MMAR_0101|M.marinum_M PPALSATDGD--------------------CPTSDGPAEL---------- Rv2048c|M.tuberculosis_H37Rv VGGLLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAI MAV_2450|M.avium_104 VGALLVPPEDGPWRLGMSSYGTIENLRLEPIPDADAPLGPGQVRVATSAL TH_2454|M.thermoresistible__bu GPGARDSAGEGLRCSPGG-------------------------------- . MAB_0939|M.abscessus_ATCC_1997 GLNFRDVLNVLGLYPGDPGPIGGDFAGIVTQLGEGVTGVEVGQRVYGSMQ Mvan_0269|M.vanbaalenii_PYR-1 GLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGSGVTGLEVGQRVYGFMQ Mflv_0405|M.gilvum_PYR-GCK GLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQ MSMEG_0408|M.smegmatis_MC2_155 GLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGAGVSGLEIGQRVYGSMQ Mb2971c|M.bovis_AF2122/97 GVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL- MLBr_00135|M.leprae_Br4923 GVNFRDVVAALGMYPGQAPPLGAEGAGVVIEIGPEVTGVAVGDAVMGFL- MUL_2005|M.ulcerans_Agy99 GVNFRDVVAALGMYPGAAPPLGAEGAGVVLEVGPQVSGVAVGDSVMGFL- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv AANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFP MAV_2450|M.avium_104 AANFRDVMIALGLYPDPDAVMGIEASGVVIETASQDGRVAVGDRVMGLFP TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GAFGSRFNVPAQFLAPIPDGISGVEAATIPAAALTVR-LSFDWAQLKPGD Mvan_0269|M.vanbaalenii_PYR-1 GAFASRFNVPAQLLAPIPDGIGAVDAATIPAAALTAR-LAFDWAQLKPGD Mflv_0405|M.gilvum_PYR-GCK GAFASRFNVPGQFLAPIPDGVSAVEAATIPAAALTVR-LSFDWAQVKSGD MSMEG_0408|M.smegmatis_MC2_155 GAFASRFNVPAQFLAPIPDGIGAVEAATIPAAALTVR-LAFDWAQLKPGD Mb2971c|M.bovis_AF2122/97 GGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGE MLBr_00135|M.leprae_Br4923 GGAGPLAVVHQQLITQMPQGWSLAEAAAVPVVFLTALFGLADLAGIRAGE MUL_2005|M.ulcerans_Agy99 GGAGPLSVVDQQLITRMPQGWSFAQAAAVPVVFLTALFGLQDLAKIQPGE MMAR_0101|M.marinum_M -------------------------------------------------A Rv2048c|M.tuberculosis_H37Rv EGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARSGQ MAV_2450|M.avium_104 DGTGTVATTDQRLLVKVPAGWSHTAAATASVVFATAYYALVDLADARPGQ TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 KVLIHAASGGVGLAAIQMAQQFGAEVFATASTFKRATLRKLG--VKYVYD Mvan_0269|M.vanbaalenii_PYR-1 RVLIHAASGGVGLAAIQMAQQHGAVVFATASTYKRATLRKLG--VDHVYD Mflv_0405|M.gilvum_PYR-GCK KVLIHAASGGVGLAAVQMAQQCGAEVYATASTFKRATLRKLG--VKHVYD MSMEG_0408|M.smegmatis_MC2_155 KVLIHAASGGVGLAAIQMAQQSGAEVFATASTFKRSTLRRLG--VKYVYD Mb2971c|M.bovis_AF2122/97 SVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGD MLBr_00135|M.leprae_Br4923 SVLIHAGTGGVGMAAVQFARHWGVEIFVTASRGKWDTLRDMGFDDDHIGD MUL_2005|M.ulcerans_Agy99 SVLIHAGTGGVGMAAVQLARHWGVEIFVTASRGKWDTLRAMGFDDDHIGD MMAR_0101|M.marinum_M SVLDPAGT------------------------------------------ Rv2048c|M.tuberculosis_H37Rv RVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISD MAV_2450|M.avium_104 RVLVHAAAGGVGMAAVQLARHLGLEVFATASRGKWDTLRDMGFDDDHLGD TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SRTTDFADQILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAK Mvan_0269|M.vanbaalenii_PYR-1 SRTTEFADQILADTDGEGVDVVLNSLTNEGFIEATVRATAQNGRFAEIAK Mflv_0405|M.gilvum_PYR-GCK SRTTDFAEQILADTDGAGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAK MSMEG_0408|M.smegmatis_MC2_155 SRTTDFADQILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAK Mb2971c|M.bovis_AF2122/97 SRTCEFEEKFLAVTEGRGVDVVLDSLAGE-FVDASLRLLVRGGRFLEMGK MLBr_00135|M.leprae_Br4923 SRTLEFEEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGK MUL_2005|M.ulcerans_Agy99 SRTLDFEEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGK MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv SRSLEFEDKFRAATGGRGFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGK MAV_2450|M.avium_104 SRGLDFEDKFRAVTGGAGMDIVLDSLSGD-SVDASLRLVAPGGIFLEMGK TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 RDIWTTEQMAQSRPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKG-- Mvan_0269|M.vanbaalenii_PYR-1 RDIWTPEQMAAARPDIAYEIVALDTVTLLEPERIRGLLGEVSDGLGKADG Mflv_0405|M.gilvum_PYR-GCK RDIWTVEQMAAARPDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDG-- MSMEG_0408|M.smegmatis_MC2_155 RDIWSHEQMAEARPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARG-- Mb2971c|M.bovis_AF2122/97 TDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELH-- MLBr_00135|M.leprae_Br4923 TDIRDAQEIAANYPGVQYRAFDLSEAGPVRMQEMLCEVRELFDTQVLH-- MUL_2005|M.ulcerans_Agy99 TDIRDADKIAANYPGVWYRAFDLSEAGPVRMQEMLAEVRELFDTAVLH-- MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv TDIRDPGVIAQQYPGVRYRAFDLFEPGPDRIAQILAELATLFGDGVLR-- MAV_2450|M.avium_104 TDIRDPEVVAAEHPGVRYRAFDLFEAGPDRIARLLDELAAMFGEDVLR-- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ----EWTPLPAEIYPLTEARTAFRRMQQARHIGKIVCQMPNPLAPR-PDR Mvan_0269|M.vanbaalenii_PYR-1 SSRAEWVPLPAEIYPLTEARAAFRRMQQARHVGKIVLQMPKPLQPR-ADR Mflv_0405|M.gilvum_PYR-GCK ----AWTPLPAEVYPLTEARAAFRRMQQARHIGKIVVQIPNPLQPQ-PDR MSMEG_0408|M.smegmatis_MC2_155 ----EWTPLPAEIYPITEARSAFRRMQQARHIGKIVLQVPKPLQPQ-QDR Mb2971c|M.bovis_AF2122/97 -------RLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADG MLBr_00135|M.leprae_Br4923 -------RLPVTSWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLAEG MUL_2005|M.ulcerans_Agy99 -------RLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLADA MMAR_0101|M.marinum_M -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------PLPVTTFDVRCAPAALRYLSQARHTGKVVMLMPGSWAAG---- MAV_2450|M.avium_104 -------PLPVTRFDVRRAPAALRYLSQARHVGKVVMTMPDAWTAG---- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 TYLITGGLGAIG-LHTAAYLAQLGAGDIVLTSRRAPDTDA---------Q Mvan_0269|M.vanbaalenii_PYR-1 SYLITGGLGAIG-LHTAAYLAQLGAGDLVLTSRRAPDADA---------R Mflv_0405|M.gilvum_PYR-GCK SYLITGGLGAIG-LHTAGYLAQLGAGDIVLTSRRAPDAAA---------Q MSMEG_0408|M.smegmatis_MC2_155 SYLITGGLGAIG-LHTAAYLAQLGAGDIVLTSRRDPDESA---------Q Mb2971c|M.bovis_AF2122/97 TVVITGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEG---------A MLBr_00135|M.leprae_Br4923 TVLITGASGAIGGVLARHMVSAYGVRHLVLASRRGDRAEG---------A MUL_2005|M.ulcerans_Agy99 TVLITGATGAVGAVLARHMLDGYGVRHLVLASRRGDRAEG---------A MMAR_0101|M.marinum_M -VLITGGTGMAGGVLARHVVGAGGVRHVVLASRQGEQAPG---------V Rv2048c|M.tuberculosis_H37Rv TVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPG---------A MAV_2450|M.avium_104 TVLITGATGMAGSAVARHVVTRHGARNLVLVSRRGLDAPD---------A TH_2454|M.thermoresistible__bu TYLITGGTGALG-LRLAHRLADLGARRLVLVSRSGMPARDSWGRAGDSDT :***. * * : *. :**.** MAB_0939|M.abscessus_ATCC_1997 RVIGEITERSKTRIHVFTADVGAESEVAGLLERIRAELPPLAGVAHLAGV Mvan_0269|M.vanbaalenii_PYR-1 RAIEEITERYKCRVHTFCADVGDESQVAELLARIRAELPPLAGVAHLAGV Mflv_0405|M.gilvum_PYR-GCK QAIADIADRTKARLHVFTADVGVEADVAALLERIRAELPPLAGVAHLAGV MSMEG_0408|M.smegmatis_MC2_155 RAIDEITERHKCRIHTYAADVGDEAQVADLLARIRAELPPLAGIAHLAGV Mb2971c|M.bovis_AF2122/97 AELAADLTEAGAKGQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGV MLBr_00135|M.leprae_Br4923 VELAAELVGAGAKIQVVACDVADNDAVRGLFAQLSREFPPVRGVIHAAGV MUL_2005|M.ulcerans_Agy99 AELAAELSEAGANVQVVACDVADRDAVEAMLARLSGEYPPVRGVIHAAGV MMAR_0101|M.marinum_M AELVSELSAAGAEVLVLACDVADRDAVAQMMEQVRRRCPPLTGVIHAAGV Rv2048c|M.tuberculosis_H37Rv AELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHP-LSGVIHTAGA MAV_2450|M.avium_104 AELVAELTAAGAHAEVVACDAADREALAKVIADIPMQHP-LTGVIHAAGV TH_2454|M.thermoresistible__bu VAAITALEERGVSVRVAALDIG-APGAAARLREVLADLPDVRGVIHAAGV . * . : : * : *: * **. MAB_0939|M.abscessus_ATCC_1997 LDDALLGQQSVERFRTTLAPKAFGAEYLDRLTKGDDLDFFIVSSSVSSLF Mvan_0269|M.vanbaalenii_PYR-1 LDDALLSQQSLERFRTTLAPKAFGACHLDRLTAGDDLDFFIMSSSVSSLF Mflv_0405|M.gilvum_PYR-GCK LDDALLSQQSVERFRTALAPKAFGAVHLDRLTRVDDLDFFLVSSSVSSLF MSMEG_0408|M.smegmatis_MC2_155 LDDALLSAQNPERFRTTLAPKAYGASHLDRLTRDDDLDFFIVSSSVSSLF Mb2971c|M.bovis_AF2122/97 LDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFVLCSSIAATV MLBr_00135|M.leprae_Br4923 LDDGAITSLTPDRVDTVLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATV MUL_2005|M.ulcerans_Agy99 LDDAVISSLTPERIDTVLRAKVDAAWNLHEATLDLDLSMFVLCSSIAATV MMAR_0101|M.marinum_M LDDTVIASLTPDRMNPVLRAKVDGAWHLHQLTRGLGLSMFVLCSSIAGVM Rv2048c|M.tuberculosis_H37Rv LDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLV MAV_2450|M.avium_104 LDDAVVTSLTPQRIDTVLRAKVDAAWNLHELTRDLDVGAFVMFSSIAGLA TH_2454|M.thermoresistible__bu EAGALLTNTTAEDIEATMRPKVDGVLALHEVFPPGRLDWLVLFSSCGYLG . : . : . .: .*. .. *.. : ::: ** . MAB_0939|M.abscessus_ATCC_1997 GSPGQSNYATANALLDGLIAQRRAQGLPATGINFGPWGQGGMASSEAAT- Mvan_0269|M.vanbaalenii_PYR-1 GSPGQANYATANALLDGLTAHRRARGLPATGVNFGPWAQGGMASSEAAT- Mflv_0405|M.gilvum_PYR-GCK GSPGQSNYATANAFLDGLVAQRRAQGLPATGVNFGPWARGGMASSEAAA- MSMEG_0408|M.smegmatis_MC2_155 GSPGQANYATANAMLDGLVAKRRAQGLVATGINFGPWGQGGMASSEAAT- Mb2971c|M.bovis_AF2122/97 GSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSR MLBr_00135|M.leprae_Br4923 GSPGQGNYSAANAFLDGLAAYRQAAGLAGTSLAWGLWEQPGGMNAHLSSR MUL_2005|M.ulcerans_Agy99 GSPGQGNYSAANSFLDGLAAHRQAAGLAGISVAWGLWEQSGGMAAHLSSR MMAR_0101|M.marinum_M GSPGQGNYAAANTFLDALAAHRRATGLAGLSVQWGLWEQTSAMTGHLGER Rv2048c|M.tuberculosis_H37Rv GSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATV MAV_2450|M.avium_104 GASGQGNYAAGNSFLDGLAAHRRAHGLPAISLGWGLWDQASAMTGGLGAA TH_2454|M.thermoresistible__bu GFPGQGAYACGNAYLDAFARYRRASGDATTSVAWTAWRGLG--MGSASDF * .**. *: .*: **.: *:* * .: : * . . . MAB_0939|M.abscessus_ATCC_1997 --ANISAQGLIPLDPSAALAALAEVVANGTGQATILKANWQRAAKVLGSS Mvan_0269|M.vanbaalenii_PYR-1 --ANIGAQGLVPLEPSAALGALAEVLANGTGQAAVLKANWQRAAKVLGSS Mflv_0405|M.gilvum_PYR-GCK --ANISAQGLIPLEPSAALTAMAEVVANGTAQATVLKANWQRAAKVLGSS MSMEG_0408|M.smegmatis_MC2_155 --ANITAQGLIPLDPSAALHALAEVIANGSGQATVLKANWQRAAKVLGSA Mb2971c|M.bovis_AF2122/97 DLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAG MLBr_00135|M.leprae_Br4923 DLARISRSGLAPMNPAQALELFDAALVIDHPFMVTALLDRAALDAQAQAG MUL_2005|M.ulcerans_Agy99 DLARMSRSGLAPMNPEQAVGLLDAVLAINHPLMVATLLDRPALEARAQAG MMAR_0101|M.marinum_M DLARIRRSGLAPMSVGQAVELFDAAVLLDRSTVVAACLDRNALASPAVSA Rv2048c|M.tuberculosis_H37Rv DFKRFARDGIVAMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGG MAV_2450|M.avium_104 DLARFGRDGIVAMSSQEALELMDTALIVDEPFLLPAHIDLAALRVKFDGG TH_2454|M.thermoresistible__bu VAAQLDALGMGTVDVDDAMRALDAAIRDGDPNVVVLPLSPAAAAVPMFAD .: *: .:. *: : .: . . . MAB_0939|M.abscessus_ATCC_1997 RPP---------ILDLVLPSAVGEVTGDSELLKQLMEIPVPQRAGFVTEF Mvan_0269|M.vanbaalenii_PYR-1 RPP---------ILDLVLPRPEGEVAGDSELLRQLQEIPVAQRAGFVTEF Mflv_0405|M.gilvum_PYR-GCK RPP---------ILDLVLPSAVGEITGDSELLKQLQEIPVPQRAGFVTEF MSMEG_0408|M.smegmatis_MC2_155 RPP---------ILDLVLPSAAGEATGDSELLKQLMEIPIPQRAGFVTEF Mb2971c|M.bovis_AF2122/97 ALPALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGL MLBr_00135|M.leprae_Br4923 ALPPLFSRLVRRSRRRQIEDPGDATQSKLALVQRLQGLAANRQLELLVGV MUL_2005|M.ulcerans_Agy99 GLPPLFAGVVRRPRRRQIEDTGDAAQSKSALAERLNGLSAGERQDALVGL MMAR_0101|M.marinum_M ELPMLFHSLLPRPSRRVIN--KDATTHESGLAQRLQALSPHQQHQLLVET Rv2048c|M.tuberculosis_H37Rv TLPPMFVDLINAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQHAVLLDL MAV_2450|M.avium_104 TLPPMFVDLINAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQQAVLLDL TH_2454|M.thermoresistible__bu VAP----------ADPDADAPGGEVPDGLSDGFPADGFPDDGDLAEWVHR * :. MAB_0939|M.abscessus_ATCC_1997 LQREVQNFLRLAQPPAATSR--FLDLGTDSLMAIELRNRLHSQFGGKFTI Mvan_0269|M.vanbaalenii_PYR-1 LQREVQNFLRLAQPPAATSR--FLDLGTDSLMAIELRNRLHSQFGGAFTI Mflv_0405|M.gilvum_PYR-GCK LQKEVQNFLRLAQPPAATSR--FLDLGTDSLMAIELRNRLHSQFGGAFTI MSMEG_0408|M.smegmatis_MC2_155 LQREVQNFLRLASPPAASSR--FLDLGTDSLMAIELRNRLHSQFGGKFTI Mb2971c|M.bovis_AF2122/97 VCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATG--LTL MLBr_00135|M.leprae_Br4923 VCLQAAAVLGRPSPEDIDPNTKFQDLGFDSLTAVELRNRLKSATG--LTL MUL_2005|M.ulcerans_Agy99 VCLQAAAVLGRPSPEDIDPEAGFQDLGFDSLTAVELRNRFKSATG--LTL MMAR_0101|M.marinum_M VRNQAAVVLGRPSGQDIDPECTFQDLGLDSLTAVELRNRLKAASG--LSL Rv2048c|M.tuberculosis_H37Rv VRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEMRNRLKSATG--LAL MAV_2450|M.avium_104 VRSNIATVLGSSSPEAIHPDRAFQELGFDSLTAVEMRNRLKAATG--LAL TH_2454|M.thermoresistible__bu RVIAAVAGELGLAETDVDPRLPLVEIGVDSIMTVALRRQLERQTG--LTL . : ::* **: :: :*.::. * ::: MAB_0939|M.abscessus_ATCC_1997 NATAVFDYPTIGGLAEYLVGQLPDADAESAEAPPAVESAEAESGAGPAAA Mvan_0269|M.vanbaalenii_PYR-1 NATAVFDYPTIGGLAEYLVGQLPDSDAAAGETPATETSPIDHNHPDREAD Mflv_0405|M.gilvum_PYR-GCK NATAVFDYPTIGGLAEYLVAQLPD-----AETPQAAPQSESEPGPDVTE- MSMEG_0408|M.smegmatis_MC2_155 NATAVFDYPTIGGLAEYLVGQLPD-----AEAPETA-------------- Mb2971c|M.bovis_AF2122/97 PPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA- MLBr_00135|M.leprae_Br4923 PPTVIFDHPTPTAVAEYVAQQMLKSRPAESGDETSQAVEPKVEEVSVHA- MUL_2005|M.ulcerans_Agy99 PPTVIFDHPTPTAIAEYVGRQIPDSQATQAEEE--KLPESDGEMVSVTA- MMAR_0101|M.marinum_M SPTLIFDYPTPATLARHLAQQLIGTGTTGSAQIESQLETLQQTLLAIEDG Rv2048c|M.tuberculosis_H37Rv SPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAELQRIVASIPVK MAV_2450|M.avium_104 SPTLIFDYPNSAALAGYMYRELVGTSEQPTAAAAPGEAEIQRVVGSIPVK TH_2454|M.thermoresistible__bu PPTLLWEHPTAGAVSDRIVEMLRARG------------------------ .* ::::*. :: : : MAB_0939|M.abscessus_ATCC_1997 SDAVSELKE----------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 SPG----------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_0101|M.marinum_M DKQRV-AAQLRKFLTRLLAPAESGRPLDDRIKDATSPSEILQLIDAGSIE Rv2048c|M.tuberculosis_H37Rv RLRQAGVLDLLLALANETETSGQDPALAPTAEQEIADMDLDDLVNAAFRN MAV_2450|M.avium_104 RLRQAGVLELLLALANESTGTAQSATPAVTTEKDIADMDLDDLVNAALLD TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ---- Mvan_0269|M.vanbaalenii_PYR-1 ---- Mflv_0405|M.gilvum_PYR-GCK ---- MSMEG_0408|M.smegmatis_MC2_155 ---- Mb2971c|M.bovis_AF2122/97 ---- MLBr_00135|M.leprae_Br4923 ---- MUL_2005|M.ulcerans_Agy99 ---- MMAR_0101|M.marinum_M S--- Rv2048c|M.tuberculosis_H37Rv DDE- MAV_2450|M.avium_104 DDDE TH_2454|M.thermoresistible__bu ----