For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. marinum M MMAR_0101 (-)

annotation: polyketide synthase PKS
coordinates: 115545 - 122879
length: 2444

MRNNNLAWLLANQALASEWSASPAYYAPNIVTHAQIHEGAARLGNVFGSRGLRTGDRVLLCLPDSTDLVQ
LLLACLARGIVAFISNPELRPDDHTFQEQDTQPALVVTTDALRDRFARSGIVDPGELWAEANQAKPAAYE
PLTGDALAYGTYTSGTTGAPKAALHRHGDVWAFIDAMCRNALRLTPDDVGLSIARMYFAYGLGNSVWFPL
ATGSSAVISRSPLGAESAANLSERFSPSVLYGVPTFLARVADTCAADAFRSLRCVVSAGEALELGLAQRL
MKFFGGIPLLDGIGSTEVGQTFISSTVDEWRLGTLGKVLSPYEIRVVAPDGTTAAPGVEGDLWVRGPSLT
AGYWNRPTQPPSISDSWLDTRDRVCVDAHGWVTYRCRADDIEIVGGININPREIEQLIVEDHLVAETAVV
AVREATGESALQAFLVPESGASLGESAIKELHRRLLGSLSPHKVPHRFEIAERLPRTASGKLQRGQLRTQ
PAAQPVWERRCTVGTSDSDGQRDPQTQTNYKVGPRVGPVTLDERLAVLQQEGHRLIADTVSAEVAQILGD
PAAERIDRDVAFAELGFDSRMTVELRNRLAAVTGLRLPETVGWDYGSISRLAAHLETELAGSGGRGKPGP
SVAGGAPVAIVGVGCRYPGGVESAGGLWDVVVGGRDVISGFPVDRGWDVEGVFDPDPDALGKTYCRLGGF
LDGADRFDAGFFGIGPSEALAMDPQQRLLLECSWEALEDAGIDPVSLRGSVTGVFTGLMSSDYGAGRVSG
DLEGYGLTSAAASVASGRVAYLLGLEGPAVSVDTACSSSLVALHLAASSLRSGECDVALAGGVTVMATPA
TFVGFSRQRGLAADGRCKAFAGAADGTGFSEGAGVVVLMRLSEARRRGLAVLGVIAGSAVNQDGASNGLT
APNGPAQQRVIEAALANAGLTAADVDVVEGHGTGTTLGDPIEAQALLATYGQARPADQPLWLGSIKSNMG
HTQAAAGIAGVIKMVQAMRHELMPATLHVDVPSPHVDWSSGAVSLLTQPRPWPAVDGRPRRAGVSSFGIS
GTNAHVIVEQVCPEVVAEAVDVSPDSLPWVVSGKSEAAVAAQAKRLLAAVQADEGLDRLDVGFSLARRTA
FEYRAVVLGEDRQQLISGLTELAAGQPGPTVLNGRAATVSKTVMVFPGQGSQRLGMGQQLHGQFPVFAQA
FDAVVEQLDRYLRLPLRDALWGGDEHLLESTEFAQPSLFAVEVALFALLRDWGVSPDVVMGHSVGELSAA
HVAGVLTLDDAAKLVAARGRLMQALPEGGAMFAIAASEHEVSPLLGEAVGIAAINAPDAVVISGERAAVG
VLAEELIDRGRRVHRLAVSHAFHSPLMEPMLADFALAAGDITAHPPRIALVSNLTGELAGPDYGSAQYWV
EHVRRPVRFADSVRNLEELGASHFIEVGPGGGLSSAIAQSLRSPEAVTVPVLGKDRPEVNSLISAVGQLF
STGVGVDWSAVFAGSGGRQVGLPTYAFARRRFWLDGSASAADVGEAGLVAAGHALLGAVVEQPDTGAVVL
TGRLSLARQPWLADHLVGGAVLFPGTGFVELAIRAGDEVGCGVVEELTLATPLVLNAGTAVQVQVVVGSA
GQSGQRLVSMYSRADQPDQHWVLHAQGSVAPAAVQPAAAASAELSTWPPAGAEAVDIGGLYERLARRGYG
YGPAFQGLRAVWRRGRDVFAEVGLPNDEGLDLTDVGIHPALLDAVLHATMAAAGADVAEMRLPFSWRGVS
LHAAGAAGLRARIAALDGGDGAAVSVELADAAGLPVLSVDSLVTRPVTANQLNAAIAAAAGAPDDKLLEV
AWSPIALNDRTIGGRDDVPVMLWDDHRDDDGHGAGTVVIWESCCAADDDVVRSAYAATHAALAVLQSWLS
GDRPGTLVIVTHGGVALTDEGVKDLAAAAVWGLVRSAQSEHPGRIVLIDTDSAPTDPEVLMDLANLAGRG
EPQLLVSGGAVYGARLAPIPPALSATDGDCPTSDGPAELASVLDPAGTVLITGGTGMAGGVLARHVVGAG
GVRHVVLASRQGEQAPGVAELVSELSAAGAEVLVLACDVADRDAVAQMMEQVRRRCPPLTGVIHAAGVLD
DTVIASLTPDRMNPVLRAKVDGAWHLHQLTRGLGLSMFVLCSSIAGVMGSPGQGNYAAANTFLDALAAHR
RATGLAGLSVQWGLWEQTSAMTGHLGERDLARIRRSGLAPMSVGQAVELFDAAVLLDRSTVVAACLDRNA
LASPAVSAELPMLFHSLLPRPSRRVINKDATTHESGLAQRLQALSPHQQHQLLVETVRNQAAVVLGRPSG
QDIDPECTFQDLGLDSLTAVELRNRLKAASGLSLSPTLIFDYPTPATLARHLAQQLIGTGTTGSAQIESQ
LETLQQTLLAIEDGDKQRVAAQLRKFLTRLLAPAESGRPLDDRIKDATSPSEILQLIDAGSIES
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_0101--100% (2444)polyketide synthase PKS
M. marinum MMMAR_3796-0.058.28% (1764) type I modular polyketide synthase
M. marinum MMMAR_0102-0.072.78% (1407) polyketide synthase PKS

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2971cpks10.066.86% (1361) polyketide synthase PKS1
M. gilvum PYR-GCKMflv_0405-0.037.45% (1546) beta-ketoacyl synthase
M. tuberculosis H37RvRv2048cpks120.059.76% (1476) polyketide synthase pks12
M. leprae Br4923MLBr_00135-0.063.61% (1418) putative polyketide synthase
M. abscessus ATCC 19977MAB_0939-0.039.58% (1281) polyketide synthase
M. avium 104MAV_2450-0.060.54% (1447) erythronolide synthase, modules 3 and 4
M. smegmatis MC2 155MSMEG_0408-0.037.79% (1519) type I modular polyketide synthase
M. thermoresistible (build 8)TH_2454-0.031.93% (1826) PUTATIVE beta-ketoacyl synthase
M. ulcerans Agy99MUL_2005pks15/10.062.35% (1458) polyketide synthase Pks15/1
M. vanbaalenii PYR-1Mvan_0269-0.037.13% (1535) beta-ketoacyl synthase

CLUSTAL 2.0.9 multiple sequence alignment


MAB_0939|M.abscessus_ATCC_1997      ------------------------MDSAENPIESTPRFAIIGYAARFPG-
Mvan_0269|M.vanbaalenii_PYR-1       ------------------------MGSAEHPNGPAPRFAIVGYAARFPG-
Mflv_0405|M.gilvum_PYR-GCK          ------------------------MGSAAHQGESAHRFAIVGYAGRFPG-
MSMEG_0408|M.smegmatis_MC2_155      ------------------------MVSAEHPIEPTPSFAIIGYAARFPG-
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG
MAV_2450|M.avium_104                MMVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      AADAEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVVTRRAGF
Mvan_0269|M.vanbaalenii_PYR-1       APDADAFWDVLREGRDAISDVPRDR-WDAEEFFDPEPGAPGKVVTRRAGF
Mflv_0405|M.gilvum_PYR-GCK          ARDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVVTRRAGF
MSMEG_0408|M.smegmatis_MC2_155      AASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVVTRRAGF
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        VDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGF
MAV_2450|M.avium_104                VDSPEALWQMVAEGRDVISEFPTDRGWDLAALYDPDPDARHKCYVNTGGF
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      VEDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAPTDLAET
Mvan_0269|M.vanbaalenii_PYR-1       VDDVTGFDAPFFGMSTREVRMMDPQHRLLLETAWRAVEHSGTAPTALAGS
Mflv_0405|M.gilvum_PYR-GCK          VDDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANT
MSMEG_0408|M.smegmatis_MC2_155      VDDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANS
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        VDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS
MAV_2450|M.avium_104                VDNVADFDPAFFGIAPSEALAMDPQHRMLLELSWEALERAGIDPSGLRGS
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      NSGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRISYRLGLQ
Mvan_0269|M.vanbaalenii_PYR-1       NTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQ
Mflv_0405|M.gilvum_PYR-GCK          NTGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQ
MSMEG_0408|M.smegmatis_MC2_155      NTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQ
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        ATGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLE
MAV_2450|M.avium_104                ATGVFAGLIVQGYG------MLAEEIEGYRLTGMTSSVASGRVSYVLGLE
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      GPSVAVDTACSSSLVAIHQACQALQLGECDLALAGGANVLLTPATMITFS
Mvan_0269|M.vanbaalenii_PYR-1       GPAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVLLTPATMITFS
Mflv_0405|M.gilvum_PYR-GCK          GPAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVILTPATMITFS
MSMEG_0408|M.smegmatis_MC2_155      GPAVAVDTACSSSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFS
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        GPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFS
MAV_2450|M.avium_104                GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      HAHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDRIRAVIR
Mvan_0269|M.vanbaalenii_PYR-1       NAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIR
Mflv_0405|M.gilvum_PYR-GCK          NAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIR
MSMEG_0408|M.smegmatis_MC2_155      NAHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIR
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        RHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV
MAV_2450|M.avium_104                RHRGLAPDGRCKAYAGAADGVGWSEGGAMLVVERLSDARRLGHPVLAVVR
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      GSAINQDGASGGLTVPNGVAQQRVIADALKRAGVAPSEVGYLEAHGTGTS
Mvan_0269|M.vanbaalenii_PYR-1       GSSINQDGASGGLTVPNGVAQQRVIADALKRSDLEPKDVGYLEAHGTGTS
Mflv_0405|M.gilvum_PYR-GCK          GSAINQDGASGGLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTS
MSMEG_0408|M.smegmatis_MC2_155      GSAINQDGASGGLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTS
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT
MAV_2450|M.avium_104                GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      LGDPIEAQAAGAAYGIGRETNDPLLIG-SAKTNIGHLEAAAGIAGVIKVI
Mvan_0269|M.vanbaalenii_PYR-1       LGDPIEAQAAGAVLGAGREPSRPLLIG-SAKTNIGHLEAAAGIAGVIKVI
Mflv_0405|M.gilvum_PYR-GCK          LGDPIEAQAAGAALGPGREPQRPLLIG-SAKTNIGHLEAAAGIAGVIKVV
MSMEG_0408|M.smegmatis_MC2_155      LGDPIEAQAAGEVLGAGRAPEEPLLIG-SAKTNIGHLEAAAGIAGVIKVV
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        LGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMV
MAV_2450|M.avium_104                LGDPIEAQALLATYGQDRGQP---LWLGSIKSNMGHTQAAAGVAGVIKMV
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      LSLENELLPQHRNFQNPSPHIPWDRLPVEVVREARPWGRN---GRPRIAG
Mvan_0269|M.vanbaalenii_PYR-1       LSLEHRTLPKHLNFENPSPHIPWDRLAVEVVKETIPWERD---GGPRIAG
Mflv_0405|M.gilvum_PYR-GCK          LSLEHETLPKHLNFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPRIAG
MSMEG_0408|M.smegmatis_MC2_155      MALENETLPKHLNFETPSPHIPWERLPIEVVRETVPWQRN---GKPRIAG
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        LAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAGARTRRAGVS-
MAV_2450|M.avium_104                LAMRHELLPATLHVDEPSPHVDWSAGAVSLLTEAQPWPG-ERPRRAGVS-
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      VSSFGFAGTNAHVILEEAPVVSRDAVEPPAPAGGRKFSILPLSARTPAAL
Mvan_0269|M.vanbaalenii_PYR-1       VSSFGFAGTNAHVILEEAP--EQAAAPGPVQQPDRRFSLLPLSARTPAAL
Mflv_0405|M.gilvum_PYR-GCK          VSSFGFAGTNAHVILEEAP---LAAEPAQESVDDGRFTLLPLSARTPAAL
MSMEG_0408|M.smegmatis_MC2_155      VSSFGFAGTNAHVILEEAPAVGTPATTEPVE-DPRRYSVLPLSARTPEAL
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        --SFGISGTNAHVIIEAVP-VVPRREAGWAGPVVPWVVSAKSESALRGQA
MAV_2450|M.avium_104                --SFGISGTNAHVIIEAVPAVEPAHADAPALPVLPWVVSAKSAAALRAQA
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      AQLADKYRAWLNAHPEAALADLCFTAGVGRAHLEHRAALVVNTREAAVEL
Mvan_0269|M.vanbaalenii_PYR-1       TQLAGQYRDWWTAHPEATLADVCFTAGAGRAHLEHRAALVVNSAESAVEL
Mflv_0405|M.gilvum_PYR-GCK          MAVADRYRDWLVANPDATLADLCFTAGTARSHLEHRAALVVNTREAALDL
MSMEG_0408|M.smegmatis_MC2_155      VRLAGEYRDWLRAHPQARLADVSHTAGTARAHLEQRAALVVNSRESAIEL
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        ARLAAYVRGDDGLDVADVGWSLAGRS-----VFEHRAVVVGGDRDRLLAG
MAV_2450|M.avium_104                ARLAEYVRAQGELDIADVGWTLAGRA-----TFEHRAVVVGGDRDRLLAG
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      LSAVADDRPAPGLGRGESHDTPKTAWLFTGQGSQYPGMARELFETEPVFA
Mvan_0269|M.vanbaalenii_PYR-1       LGALADDRPAPGLVRGESHDTPKTAWLFTGQGSQYPGMARELYDTEPVFA
Mflv_0405|M.gilvum_PYR-GCK          LGALADDRPAPGLVRGESHDTPKTAWLFTGQGSQYPGMSRELFDTEPLFA
MSMEG_0408|M.smegmatis_MC2_155      LGALADDRPAPGLVRGESHEAPKTAWLFTGQGSQYPGMARELFDTEPVFA
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        LDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFA
MAV_2450|M.avium_104                LDELAADDPAASIIRGVATPAGKTVFVFPGQGSQWLGMATELLDTAPVFA
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      DTLNRCAAAVADVLEKPLLDVIFDVD---GPEAEETLRQTSYAQPALFAV
Mvan_0269|M.vanbaalenii_PYR-1       ETLNRCAEAVADVLEKPLLDVIFDAE---ADDAEKTLQNTCYAQPALFAV
Mflv_0405|M.gilvum_PYR-GCK          ETLRECAAAVDGMLEKPLLDVIFDTDGVLDTDSNETLRHTSYAQPALFAV
MSMEG_0408|M.smegmatis_MC2_155      ETVRKCAEAVADILEKPLLDVIFDAD-ELDGDTESPLRHTTYAQPALFAV
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        QQIDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPVLFAV
MAV_2450|M.avium_104                QHIQACEEAFAEFVDWSLIDALRGAP------GAAGMDRVDVVQPALFAV
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      EMGLARLWQSWGFEPDVVLGHSVGQYSAACVAEVFSLEDGARLIAERGRL
Mvan_0269|M.vanbaalenii_PYR-1       EMGLARLWQSWGFEPDVVLGHSVGQYSAACVAGVFSLTDGARLMAERGRL
Mflv_0405|M.gilvum_PYR-GCK          EMGLARLWQSWGFEPDVVLGHSVGQYAAACVAGVLSLRDGARLMAERGRL
MSMEG_0408|M.smegmatis_MC2_155      ELGLARLWQSWGFEPDVVVGHSVGQYSAACVAGVFDVEDGARLIAERGRL
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        MVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKL
MAV_2450|M.avium_104                MVSLAELWKSVGVSPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKL
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      FSSLPAGGRMAAVFTDAERAERLTDEFPSLS--VAAYNGANTVLSGPAQD
Mvan_0269|M.vanbaalenii_PYR-1       FGSLPEGGRMVAVFTTAERAEAMTDEFPSLS--VAAYNGTNTVLSGPAGD
Mflv_0405|M.gilvum_PYR-GCK          FGSLPSGGRMAAVFAAAERVEALTDEYPALS--VAAYNGANTVLSGPATD
MSMEG_0408|M.smegmatis_MC2_155      FGSLPAGGRMAAVFTAPERAERLTDEYPSLS--VAAYNGANTVLSGPAKD
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        LAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSGEVGA
MAV_2450|M.avium_104                LRSLAGPGGMLSIACSTERARELLAPYGNRVSIAAVNGRSAVVVSGEGAA
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      LEKAIAALVADGVRCDFLETSHAFHSALLDPILDEFEAYANQFNYKTPQR
Mvan_0269|M.vanbaalenii_PYR-1       LEKAVATLSADGVRCDWLDTSHAFHSALLDPILDDFESYANQFDFAAPQR
Mflv_0405|M.gilvum_PYR-GCK          LERAVAGLVADGVRCDWLETSHAFHSALLDPILDDFESYARGITFTAPQR
MSMEG_0408|M.smegmatis_MC2_155      LESAVATLVADGVRCDWLDTSHAFHSALLDPILDDFESFAQKLEYREPQR
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        LEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRT
MAV_2450|M.avium_104                LDELAAFCADLALRTRRIDVDYASHSVEVEAIREDLAQALTGIEPRSSRI
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      ILIDNRTGTALGRSVKLDGAYWRRHARQPVEFAKSVRTLADMNCKVLLEI
Mvan_0269|M.vanbaalenii_PYR-1       ILIDNRTGTALGRSVQLDGTYWRRHARQPVEFAKSVRTLAEMNCKLLVEI
Mflv_0405|M.gilvum_PYR-GCK          ILIDNRTGAALGRSVTLDAAYWRRHARQPVEFAKSVHTLADMNCKLLVEI
MSMEG_0408|M.smegmatis_MC2_155      ILIDNRTGSALGRSTRLDGAYWRRHARQPVEFAKSVRTLADMNCRVLLEI
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        VFFSTVTGNRL-DTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIES
MAV_2450|M.avium_104                AFFSTVTGNRL-DTAGLDADYWYRNIRQTVQFDQTVRSAAEHGYRTFIES
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      GPQPVLTAAALRAWPDPATAPRAIASLRRNTADHRQITEAAADAYVLGHL
Mvan_0269|M.vanbaalenii_PYR-1       GPRPVLTAAALGAWPDPATAPRVIASLRRTAADHRQITEAVADAYVLGHL
Mflv_0405|M.gilvum_PYR-GCK          GPRPVLTAAALSAWPDPATSPRVIASLRRTTADQRQITEAVADAYVLGHL
MSMEG_0408|M.smegmatis_MC2_155      GPRPVLTATALAAWPDPATTPQVLASLRPTTADHRQITEAVAAAYAAGHL
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        SPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVA
MAV_2450|M.avium_104                SPHPALVAGIEDTVNDSLPGDTEAIVIPTLGRDDGGLERFLTSAATAFVA
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      PDFGAFQ--HAPARKLDLPTYPFERRQYWFSDKRDGDNRDAGNRQQNNGG
Mvan_0269|M.vanbaalenii_PYR-1       PEFGAFR--DAGARKLDLPTYPFEHRQYWFRDNQDPD----GSEALQPRT
Mflv_0405|M.gilvum_PYR-GCK          PRFAAFR--RDGARVLDLPTYPFEHRQYWFSDSREPV------AAAPQRG
MSMEG_0408|M.smegmatis_MC2_155      PDFRAFR--QPDARKLDLPTYPFEHRQFWFSDNRAIDRDTQTASAGSVTP
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        GVAVNWRGTLDGAGYVELPTYAFDKRRFWLSAEGSGADVSGLGLGASEHP
MAV_2450|M.avium_104                GVNVAWRGVLDGAGFVELPTYAFDRRRFWLSGEGAAADASGLGLGTSEHP
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      PRTEAVRLLEDGKIEELANLLGGVDGDQQTLNVLTKLAAQHN--------
Mvan_0269|M.vanbaalenii_PYR-1       PSTEAVRLLEDGRIEELATLLDGAAGDQQTLDVLSRLAAQHN--------
Mflv_0405|M.gilvum_PYR-GCK          ARTETVRLLEDGRIEELAALLGGTVDDPFTFDVLNRLAAQHN--------
MSMEG_0408|M.smegmatis_MC2_155      HRTQAVRLLEDGQIEELAALIDGETVDEQTLRVLNKLAARHN--------
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        LLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGFVELAIR
MAV_2450|M.avium_104                LLSAVVELPASGGVVLTGRLSPSLQGWLTDHAVSGTVVFPGAGFVELAIR
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      --------------------------------------------------
Mvan_0269|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_0408|M.smegmatis_MC2_155      --------------------------------------------------
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        AGDEVGCSVLDELTLAAPLLLPAT----GSVAVQVVVDAGRDSNSRGVSI
MAV_2450|M.avium_104                AGDEVGCSTVEELTLQAPLMLPAKDSGIGSVAVQVLVGEADESGRRDVSI
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      --------------------------------------------------
Mvan_0269|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_0408|M.smegmatis_MC2_155      --------------------------------------------------
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        FSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLA
MAV_2450|M.avium_104                FSRPDSDSPWVCHAQGTLSTGSIEPGADLAAWPPAGATKVDIADGYQRLA
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      --------------------------------------------------
Mvan_0269|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_0408|M.smegmatis_MC2_155      --------------------------------------------------
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        TRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVL
MAV_2450|M.avium_104                ARGYGYGPAFQGLTAAWVRGDEVFAEVRLPDAAGGVTGFGVHPALLDAAM
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      --------------------------------------------------
Mvan_0269|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_0408|M.smegmatis_MC2_155      --------------------------------------------------
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        HAVVI----AGDPDELALPFAWQGVSLHATGASAVRARIAPAGPS-----
MAV_2450|M.avium_104                HALIVGHQIAGDTDEVALPFAWQGVSLHAAGASAVRARLAPAQAPGTAAS
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      -----------------LQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGV
Mvan_0269|M.vanbaalenii_PYR-1       -----------------QQRSSQSITNDRYEIRWEQSAAALSGAETDEVS
Mflv_0405|M.gilvum_PYR-GCK          -----------------QQRSTESIADDRYQIRWETAAEPPVGADAADGI
MSMEG_0408|M.smegmatis_MC2_155      -----------------QQRSTHVDPDARYEIRWDAIAS--AAASTGAAA
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               -----------------------------MRNNNLAWLLANQALASEWSA
Rv2048c|M.tuberculosis_H37Rv        -AVSVELADGLGLPVLSVASMVARPVTERQLLAAVSGSGPDRLFEVIWSP
MAV_2450|M.avium_104                RAVSLELADGLGLPVLSVRAMVARSVSERQLRAAVSAAGPDRLFEVAWAP
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      TWLLVADAAGAAQPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAAD
Mvan_0269|M.vanbaalenii_PYR-1       SWILVGDDTEATRPLVDVLSARGQRYRIFGLPVSDADEEQLGEALRLAAA
Mflv_0405|M.gilvum_PYR-GCK          TWLLVGDDTDATRPLVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAA
MSMEG_0408|M.smegmatis_MC2_155      DWILVGDDTAAVLEFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASA
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               SPAYYAPNIVTHAQIHEGAARLGNVFGSRGLRTGDRVLLCLPDSTDLVQL
Rv2048c|M.tuberculosis_H37Rv        ASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALAAVQSWLTDHESG
MAV_2450|M.avium_104                VTVPAAHGEPPVHQVFESLAAEGDPVGESYRRTHEALAAVQSWLTEHDSG
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      EDSALRIVHVAALAGQ----GSSSAQSLLRIQHQVLGGTRRLFRAAAAAE
Mvan_0269|M.vanbaalenii_PYR-1       EDSTLRIVHVGGLDSDPDPGTAPSMRSLLRMQHRILGGTRRLFRAAAAAE
Mflv_0405|M.gilvum_PYR-GCK          DATDLRIVHVAALDAA---ESDTSMKSLLRMQHRVLGGTRRLFGAAVAAQ
MSMEG_0408|M.smegmatis_MC2_155      G--ELYVVHIAAGDGA-----AAPMRDLLRVQHRTLGGLRRLFRAANDAE
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               LLACLARGIVAF-------ISNPELRPDDHTFQEQDTQPALVVTTDALRD
Rv2048c|M.tuberculosis_H37Rv        VLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATD
MAV_2450|M.avium_104                VLVVVTRGAMALAGEDVTDLSGAAVWGLVRSAQTEHPGRIVLIDSDAALD
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      LRAPIWIVTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLS
Mvan_0269|M.vanbaalenii_PYR-1       LRTPIWVVTRRAQHVTATDTVAPDQSCLWGFGRAAALELPQLWGGLADLA
Mflv_0405|M.gilvum_PYR-GCK          LRSPMWLVTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLG
MSMEG_0408|M.smegmatis_MC2_155      LRSPIWLVTRDGQRVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLS
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               RFARSGIVDPGEL------------WAEANQAKPAAYEPLTGDALAYGTY
Rv2048c|M.tuberculosis_H37Rv        DAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLG
MAV_2450|M.avium_104                DSALTAALATGEPQVLLRDGTVYTARVHGSRAVDGIMTPPEDRPWRLGIS
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      DAGTDEWAQFIGRVSVSGEASTREDQLALRGQAVHVPRLVRREELPSGKP
Mvan_0269|M.vanbaalenii_PYR-1       DGTADEWSRLLNRITAPHGPAVREDQIALRDHAVYVPRLVRRAGRPAGKP
Mflv_0405|M.gilvum_PYR-GCK          GGTSDEWSRLLNRIAATHDPAVMEDQVAVRGSTSYVPRLVHRDTLPSGKP
MSMEG_0408|M.smegmatis_MC2_155      G-ADTEWPRLIARITSPRD---GEDQIALRGDAVYAPRLVRRTGEPSDTP
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               TSGTTG---------------------APKAALHRHGDVWAFIDAMCRNA
Rv2048c|M.tuberculosis_H37Rv        SAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDA
MAV_2450|M.avium_104                SAGTFENLQLEPVPNPDAALQPGQVRVALRAIATNFRDVMITLGMFTHDA
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      LEVRSDATYLVTGGLGSIGLEIAG------------------YLAGRGAK
Mvan_0269|M.vanbaalenii_PYR-1       LQLRDDATYLVTGGLGSIGLEIAG------------------YLAAHGAR
Mflv_0405|M.gilvum_PYR-GCK          LHLRADATYLVTGGLGSLGLEIAG------------------YLAANGAG
MSMEG_0408|M.smegmatis_MC2_155      LPVREDRTYLVTGGLGAIGLEVAG------------------YLASHGAG
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               LRLTPDD-VGLSIARMYFAYGLGNSVWFPLATGSSAVIS---------RS
Rv2048c|M.tuberculosis_H37Rv        LLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPA
MAV_2450|M.avium_104                LLGGEGAGVVVEVGPGVTEFSVGDSVYGFFPDGSGTLVPGDVRLLQHKPT
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      HLVLTSRREPGEAARQRIDALAAQG-CEVRAVTADVADGHDVARLLAGIQ
Mvan_0269|M.vanbaalenii_PYR-1       HLVLTSRRAPGDATQQRIDALGAQHSCQIRVVAADVADAHDVARLLAAVA
Mflv_0405|M.gilvum_PYR-GCK          HLVLTSRRTPDEAAASRIEALRERHGCEVRVVTADVADAHAVARLLATVQ
MSMEG_0408|M.smegmatis_MC2_155      HVVLTSRREPGDDARRRLDGLREQYACDVRVITADVADAHDVARLMTTVA
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               PLGAESAANLSERFSPSVLYGVPTFLARVADTCAADAFRSLRCVVSAGEA
Rv2048c|M.tuberculosis_H37Rv        DWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLA
MAV_2450|M.avium_104                HWSYPEAAGISAVFTTAYMAFIHLADVKPGQRVLVHAAAGGVGMAAVQLA
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      AELPPLAGIVHAAGEIGTTPLSDLEDAEVDRVFAGKVWGAWHLSEAAAGL
Mvan_0269|M.vanbaalenii_PYR-1       AELPPLAGIVHAAGEIGTTPLVSLEDSEVDRVFAGKVWGAWHLSEAAADL
Mflv_0405|M.gilvum_PYR-GCK          AEMPPLAGIVHAAGEIGTTPLADLDDAEVDRVFAGKVWGAWHLSEATSDL
MSMEG_0408|M.smegmatis_MC2_155      AELPPLAGIVHAAGEIGTTPLSGLDDAEVDRVFAGKVWGAWHLSEALTDL
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               LELGLAQRLMKFFGGIPLLDGI--GSTEVGQTFISSTVDEWRLGTLGK--
Rv2048c|M.tuberculosis_H37Rv        RHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGF
MAV_2450|M.avium_104                RHLGLEVFATASRGKWDTLRAMGFDDDHIGDSRTLEFEDKFRSATGGAGM
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      K--LDFFINTSSIAAVWG--------------------------------
Mvan_0269|M.vanbaalenii_PYR-1       Q--LDFFLGTSSIASVWG--------------------------------
Mflv_0405|M.gilvum_PYR-GCK          Q--LDFFISTSSIASVWG--------------------------------
MSMEG_0408|M.smegmatis_MC2_155      RTDLDFFVSTSSIASVWG--------------------------------
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --VLSPYEIRVVAPDGTTAAPG----VEGDLWVRGPSLTAGYWN------
Rv2048c|M.tuberculosis_H37Rv        DVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRA
MAV_2450|M.avium_104                DVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVVAREYPGVRYRA
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      ----------------------------GYGQTAYSAANAFLDGLAWRLR
Mvan_0269|M.vanbaalenii_PYR-1       ----------------------------GYGQTAYGAANAFLDGLAWRLR
Mflv_0405|M.gilvum_PYR-GCK          ----------------------------GFGQAAYGAANAFLDGLAWRLR
MSMEG_0408|M.smegmatis_MC2_155      ----------------------------GFGQTAYGAANAFLDGLAWRLR
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               -----------------------------RPTQPPSISDSWLDTRDRVCV
Rv2048c|M.tuberculosis_H37Rv        FDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQA
MAV_2450|M.avium_104                FDLFEPGRPRMRQWMVELAGLFDAGVLNPLPVTTFDIRRGRAALRYLSQA
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      EQGIAGTSVNFGPWSAGMADAESRARLEQRGIKTLSPTDALAGLADVVAA
Mvan_0269|M.vanbaalenii_PYR-1       EQGISGVSINFGPWSAGMADAESRARLDQRGVRTLSPADALAGLADVVTA
Mflv_0405|M.gilvum_PYR-GCK          EQGVAGVSVNFGPWSAGMADAQSRARLEQRGIKTLSPADALAGLSDAVIS
MSMEG_0408|M.smegmatis_MC2_155      ERGVTAVSVNFGPWAAGMADAESRARLEQRGVRTLSPAEALAGMADVVAG
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               DAHGWVTYRCR----ADDIEIVGGININPREIEQLIVEDHLVAETAVVAV
Rv2048c|M.tuberculosis_H37Rv        RHTGKVVMLMPGSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSR
MAV_2450|M.avium_104                RHIGKVVMTVPGALSAGTVLITGGTGMAGSTLARHLVTGHGVRDLALLSR
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      SGS-NAVQGVIARIDWARFLPLYQQAGKRGFLAELDREVPSHLAGV--AG
Mvan_0269|M.vanbaalenii_PYR-1       AEAPGPAQGIVARIDWERFLPLYQQAGRRAFLAELEREVPDTAP----AA
Mflv_0405|M.gilvum_PYR-GCK          AAP----HPVVARVDWSRFLPLYQQAGRRGFLAELERELPAAPAQQGPAV
MSMEG_0408|M.smegmatis_MC2_155      PVQ-----GVVAKIDWSRFLPLYQQAGRRAFLSELESELPAAATGAAAPA
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               REATG-------------------------ESALQAFLVPESGASLGESA
Rv2048c|M.tuberculosis_H37Rv        RGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSG
MAV_2450|M.avium_104                TGPDAPGAAEFVAELEAAGARVQVIACDAADRAALAGVIAGISAERPLSG
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      AQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAEVTRVDVSEIREDAGFF
Mvan_0269|M.vanbaalenii_PYR-1       TPSGRTELVERLTNAPVQQRKKLLTDYLRTAVAEITRVDATEIREDAGFF
Mflv_0405|M.gilvum_PYR-GCK          TASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAEVTRVDAAEIREDAGFF
MSMEG_0408|M.smegmatis_MC2_155      TVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAEVTRVDADEIRDEAGFF
Mb2971c|M.bovis_AF2122/97           ------------------------------------------------MI
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               IKELHRRLLGSLSPHKVPHRFEIAERLPRTASGKLQRGQLRTQPAAQPVW
Rv2048c|M.tuberculosis_H37Rv        VIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF
MAV_2450|M.avium_104                VIHAAGVLDDAMITSLTPERIDAVLRAKVDAAWNLHELTRDMNLSAFVMF
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      DLGMDSLMAVELRRRMEQGVGKEIP-------------------------
Mvan_0269|M.vanbaalenii_PYR-1       DLGMDSLMAVELRRRIEQGVGREIP-------------------------
Mflv_0405|M.gilvum_PYR-GCK          DLGMDSLMAVELRRRIETGVGKEIP-------------------------
MSMEG_0408|M.smegmatis_MC2_155      DLGMDSLMAVELRRRIEQGVGKDIP-------------------------
Mb2971c|M.bovis_AF2122/97           EEQRTMSVEGADQQSEKLFHYLKKV-------------------------
MLBr_00135|M.leprae_Br4923          ---MTASVEGADQKSEKLISYLKKV-------------------------
MUL_2005|M.ulcerans_Agy99           ---MTTSGESADQQNDKLFRYLKKV-------------------------
MMAR_0101|M.marinum_M               ERRCTVGTSDSDGQRDPQTQTNYKVGPR----------------------
Rv2048c|M.tuberculosis_H37Rv        SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAM
MAV_2450|M.avium_104                SSMAGLVGSSGQGNYAAANSFLDALAAHRRAHGLPAISLAWGLWDQASAM
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      --------------------------------------------------
Mvan_0269|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_0408|M.smegmatis_MC2_155      --------------------------------------------------
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        TGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL
MAV_2450|M.avium_104                TGGLDAADLARLGRDGILALSSDEAMELFDTALIVDEPFLAPARIDLGAL
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      ---------------------------------VTLVMDHPRISDVADYL
Mvan_0269|M.vanbaalenii_PYR-1       ---------------------------------ATLAMDHPRLSDVADYL
Mflv_0405|M.gilvum_PYR-GCK          ---------------------------------VTLVMDHPRLSDAADYL
MSMEG_0408|M.smegmatis_MC2_155      ---------------------------------VTLVMDHPRLSDAADYL
Mb2971c|M.bovis_AF2122/97           --------------------------------AVELDETRARLREYEQR-
MLBr_00135|M.leprae_Br4923          --------------------------------VVELDETRARLREYEQR-
MUL_2005|M.ulcerans_Agy99           --------------------------------AVELDEARARLREYEQR-
MMAR_0101|M.marinum_M               ------------------------------VGPVTLDERLAVLQQEGHRL
Rv2048c|M.tuberculosis_H37Rv        RAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQHA
MAV_2450|M.avium_104                RAHAVAVPPMFADLVNAPTRRRVDDSLAAAKSKSALAHRLDGLPEAEQHA
TH_2454|M.thermoresistible__bu      ---------------------------------MSVDVTAKARPD-----
                                                                       :        :     

MAB_0939|M.abscessus_ATCC_1997      LGDVLG--------------------------------------------
Mvan_0269|M.vanbaalenii_PYR-1       LGEVLG--------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK          LGDVLG--------------------------------------------
MSMEG_0408|M.smegmatis_MC2_155      LVEVLG--------------------------------------------
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               IADTVS-AEVAQILGDPAAERIDRDVAFAELGFDSRMTVELRNRLAAVTG
Rv2048c|M.tuberculosis_H37Rv        VLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATG
MAV_2450|M.avium_104                VLLELVRSHIATVLGSPTAEAIDPDKAFQELGFDSLTAVEMRNRLKTATG
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      ---------------------LAEQA--KPAAQLASAVTGRTDEPIAIVA
Mvan_0269|M.vanbaalenii_PYR-1       ---------------------LAEQAPAKAGSQPASAAANRTDEPIAIVA
Mflv_0405|M.gilvum_PYR-GCK          ---------------------LTEAA---TAPKAATVVSTAADEPIAIVA
MSMEG_0408|M.smegmatis_MC2_155      ---------------------LGEQT----NVRQASTVTARTDDPIAVVA
Mb2971c|M.bovis_AF2122/97           -----------------------------------------ATEPVAVVG
MLBr_00135|M.leprae_Br4923          -----------------------------------------ATEPVAVVG
MUL_2005|M.ulcerans_Agy99           -----------------------------------------ATEPVAVVG
MMAR_0101|M.marinum_M               LRLPETVGWDYGSISRLAAHLETELAGSGGRGKPGPSV--AGGAPVAIVG
Rv2048c|M.tuberculosis_H37Rv        LSLSPTLIFDYPTPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVG
MAV_2450|M.avium_104                LALSPTLIFDYPTPNALAGYIRTELAGAPQETTHAPVVRATDDDPIAIVG
TH_2454|M.thermoresistible__bu      -------------------------------------------DPIAIIG
                                                                                *:*::.

MAB_0939|M.abscessus_ATCC_1997      VSCRFPG-APDPEAFWDVLSGGVDAIREVPEDR-FDIDEFYDPDPEVAGK
Mvan_0269|M.vanbaalenii_PYR-1       VSCRFPG-APDPEAFWEVLAGGVDAIREVPEDR-FDIDEFYDPDPDAAGK
Mflv_0405|M.gilvum_PYR-GCK          VSCRFPG-APNPEAFWDLLSGGVDAIREVPEDR-FDIDEFYDPDPDAAGK
MSMEG_0408|M.smegmatis_MC2_155      VSCRFPG-APDPESFWELLAGGVDAIREVPEDR-WDIDEFYDPDPDTPGK
Mb2971c|M.bovis_AF2122/97           IGCRFPGGVDGPDGLWDVVSAGRDVVSEFPTDRGWDVEGLYDPDPDAEGK
MLBr_00135|M.leprae_Br4923          IGCRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGK
MUL_2005|M.ulcerans_Agy99           IGCRFPGGADGPEGLWDLVSQGRDAVTEFPNDRGWDTEGLFDPDPDAEGK
MMAR_0101|M.marinum_M               VGCRYPGGVESAGGLWDVVVGGRDVISGFPVDRGWDVEGVFDPDPDALGK
Rv2048c|M.tuberculosis_H37Rv        MACRYPGGVNSPDDMWDMLIQGRDVLSEFPADRGWDLAGLYNPDPDAAGA
MAV_2450|M.avium_104                MSCRFPGGVDSPEALWQMVAEGRDVLSEFPTDRGWDLAGVYNPDPDVPGT
TH_2454|M.thermoresistible__bu      IGCRLAGRITSPEEFWGFLLAGGSNVREIPAER-WEPYLRRDPRNAAVLR
                                    :.** .*   ..  :* .:    . :  .* :* ::     :*   .   

MAB_0939|M.abscessus_ATCC_1997      TYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGY
Mvan_0269|M.vanbaalenii_PYR-1       TYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGL
Mflv_0405|M.gilvum_PYR-GCK          TYTRYGGFLDHIDEFDPEFFGLSPREAVWIEPQQRLMLETVWEGLERAGY
MSMEG_0408|M.smegmatis_MC2_155      TYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGY
Mb2971c|M.bovis_AF2122/97           TYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEHAGI
MLBr_00135|M.leprae_Br4923          TYTRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGI
MUL_2005|M.ulcerans_Agy99           TYTRWGAFVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSWEALEHAGI
MMAR_0101|M.marinum_M               TYCRLGGFLDGADRFDAGFFGIGPSEALAMDPQQRLLLECSWEALEDAGI
Rv2048c|M.tuberculosis_H37Rv        CYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLELSWEALERAGI
MAV_2450|M.avium_104                CYTRTGGFVDNVADFDPAFFGIAPSEALAMDPQQRMFLELSWEALERAGI
TH_2454|M.thermoresistible__bu      EITPWGTFLDDLAGFDAEFFGVSPREAELTDPQQRLALEVSWEALEHAGV
                                         * *::    **. ***: * *.   :**:*: **  **.** ** 

MAB_0939|M.abscessus_ATCC_1997      SPAALRGSRTGIFAGVGANEYAHLLSSESIDKIEPYFITGNALNAISGRV
Mvan_0269|M.vanbaalenii_PYR-1       APADLRGSRTGIFVGVAANEYAHLLSSESIEKIEPHFITGNALNAISGRV
Mflv_0405|M.gilvum_PYR-GCK          APSALRGSRTGVFVGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRV
MSMEG_0408|M.smegmatis_MC2_155      APSDLRGSRTGVFTGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRV
Mb2971c|M.bovis_AF2122/97           DPLSLRGSATGVYTGIFAASYGN----RDTGGLQGYGLTGTSISVASGRV
MLBr_00135|M.leprae_Br4923          DPLSLRGSATGVFTGIFAPSYGS----RDTGGLQGYGLTGTAVSVASGRV
MUL_2005|M.ulcerans_Agy99           DPMSLRGSSTGVFTGIFAPSYGG----KDVGALQGYGLTGSPVSVASGRV
MMAR_0101|M.marinum_M               DPVSLRGSVTGVFTGLMSSDYGAG---RVSGDLEGYGLTSAAASVASGRV
Rv2048c|M.tuberculosis_H37Rv        DPTGLRGSATGVFAGVMTQGYGM----FAAEPVEGFRLTGQLSSVASGRV
MAV_2450|M.avium_104                DPVKLRGSATGMFAGVYTQGYGM----GAAPIAEGFRLTGQSSSVASGRV
TH_2454|M.thermoresistible__bu      PPRSLAGTDTAVLMGVNSDDYGRLLM-EDLPGIEAWTGIGTSLCGIANRV
                                     *  * *: *.:  *: :  *.           :     .      :.**

MAB_0939|M.abscessus_ATCC_1997      AFALGFEGPAVAVDTACSSALVAVHQAVQALHSGDCDLALAGGVNVLLSP
Mvan_0269|M.vanbaalenii_PYR-1       AFALGLEGPAVAVDTACSSALVAVHQACQALHSGDCDLALAGGVNVLLSP
Mflv_0405|M.gilvum_PYR-GCK          AFALGLEGPAVAVDTACSSSLVAVHQATQALRSGDCDMALAGGVNVLLSP
MSMEG_0408|M.smegmatis_MC2_155      AFALGFEGPAVAVDTACSSALVAVHQACQALQSGDCDLALAGGVNVLLSP
Mb2971c|M.bovis_AF2122/97           SYVLGLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLP
MLBr_00135|M.leprae_Br4923          SYVLGLEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLP
MUL_2005|M.ulcerans_Agy99           AYVLGLEGPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMGLP
MMAR_0101|M.marinum_M               AYLLGLEGPAVSVDTACSSSLVALHLAASSLRSGECDVALAGGVTVMATP
Rv2048c|M.tuberculosis_H37Rv        AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATP
MAV_2450|M.avium_104                SYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGVTVNATP
TH_2454|M.thermoresistible__bu      SHLLDLRGPSVALDAACAASLVAVHNACQLLRAGETGLAIAGGVSALIGP
                                    :. *.:.**::::*:**:::***:* *   *::*: .:*:****..   *

MAB_0939|M.abscessus_ATCC_1997      VTVIAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAERDGD
Mvan_0269|M.vanbaalenii_PYR-1       VTSVAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLGDAVRDGD
Mflv_0405|M.gilvum_PYR-GCK          VTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAVRDGD
MSMEG_0408|M.smegmatis_MC2_155      VTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGD
Mb2971c|M.bovis_AF2122/97           SIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRLGH
MLBr_00135|M.leprae_Br4923          SIFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGH
MUL_2005|M.ulcerans_Agy99           SIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRNGH
MMAR_0101|M.marinum_M               ATFVGFSRQRGLAADGRCKAFAGAADGTGFSEGAGVVVLMRLSEARRRGL
Rv2048c|M.tuberculosis_H37Rv        DIFVEFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGH
MAV_2450|M.avium_104                DIFVEFSRMRGLSVDGRCKAYAGAADGTGFSEGGGMLVVERLSDARRLGH
TH_2454|M.thermoresistible__bu      GLTRVLDKAGATAPDGRCKSFDASADGYGRGEGAAVVILKRLPDALRDGD
                                          .:    :  ****::  :***   .** .:::: ** :* * * 

MAB_0939|M.abscessus_ATCC_1997      RVLAVIPGSAVNQDGASSGLTVPNGGAQQRLIGSVLARAGLVGGDVDYLE
Mvan_0269|M.vanbaalenii_PYR-1       RVCAVIPSSAVNQDGASSGLTVPNGGAQQRLIGMALARAGLSGGDVDYLE
Mflv_0405|M.gilvum_PYR-GCK          RVCAVIAGSAVNQDGASSGLTVPNGGAQQRLIGTVLARAGITGGEVDYLE
MSMEG_0408|M.smegmatis_MC2_155      RVCAVIPASSVNQDGASSGLTVPNGGAQQRLIEATLARAGLSGADVDYLE
Mb2971c|M.bovis_AF2122/97           SVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALANAGLSAADVDVVE
MLBr_00135|M.leprae_Br4923          TVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDVVE
MUL_2005|M.ulcerans_Agy99           NVLAVVRGSAINQDGASNGLTAPNGLTQQRVIQAALANCGLTSADVDVVE
MMAR_0101|M.marinum_M               AVLGVIAGSAVNQDGASNGLTAPNGPAQQRVIEAALANAGLTAADVDVVE
Rv2048c|M.tuberculosis_H37Rv        PVLAVVVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVE
MAV_2450|M.avium_104                PVLAVVRGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVE
TH_2454|M.thermoresistible__bu      RVIAVIRGGAVAQDGRTVGIMSPNGAAQRDLFRHTCEITGTSPATVDFVE
                                     * .*: ..:: *** : *:  *** :*: :.  .    *   . ** :*

MAB_0939|M.abscessus_ATCC_1997      AHGTGTPLGDPIEVQAAAAAYGGSRDAD-RPLLMGSVKSNIGHTESASGA
Mvan_0269|M.vanbaalenii_PYR-1       AHGTGTPLGDPIEVQAAAAAYGASRDAD-RPLLMGSVKTNIGHLESASGA
Mflv_0405|M.gilvum_PYR-GCK          AHGTGTPLGDPIEVQAAAAAYAGARDAD-RPLLMGSVKTNIGHTESASGA
MSMEG_0408|M.smegmatis_MC2_155      AHGTGTPLGDPIEVQAAAAAYGAGRDAD-RPLLMGSVKTNIGHTESASGA
Mb2971c|M.bovis_AF2122/97           AHGTATTLGDPIEAQALLSTYGQGRPAE-QPLWVGSIKSNMGHTQAAAGV
MLBr_00135|M.leprae_Br4923          AHGTATTLGDPIEAQALLATYGQGRPAD-QPLWVGSIKSNMGHTQAAAGV
MUL_2005|M.ulcerans_Agy99           AHGTATTLGDPIEAEALLATYGQGRPTD-QPLWVGSIKSNMGHTQAAAGV
MMAR_0101|M.marinum_M               GHGTGTTLGDPIEAQALLATYGQARPAD-QPLWLGSIKSNMGHTQAAAGI
Rv2048c|M.tuberculosis_H37Rv        GHGTGTTLGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGV
MAV_2450|M.avium_104                GHGTGTTLGDPIEAQALLATYGQDRGQP---LWLGSIKSNMGHTQAAAGV
TH_2454|M.thermoresistible__bu      AHGTGTPTGDPVELDALAAVYGAAHGPD-DPCRVGSVKPNTGHLEGGAGV
                                    .***.*. ***:* :*  :.*.  :        :**:*.* ** :..:* 

MAB_0939|M.abscessus_ATCC_1997      AGLIKVVLSLQNGVLPQSLHFDNPSPHIPWESLPVRVVDKAIPWQ-ANGR
Mvan_0269|M.vanbaalenii_PYR-1       AGLIKVVLSLQHNLLPQSLHFENPSPHIPWDSLPVRVVDKAIPWQ-ADGR
Mflv_0405|M.gilvum_PYR-GCK          AGLIKVVLSLQHETLPQSLHFDTPSPHIPWDSLPVRVVDTAMPWQ-PNGR
MSMEG_0408|M.smegmatis_MC2_155      AGLIKVVLSLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQ-TNGR
Mb2971c|M.bovis_AF2122/97           AGVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREWS-VDGR
MLBr_00135|M.leprae_Br4923          AGVIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWS-VEGR
MUL_2005|M.ulcerans_Agy99           AGVIKMVQAMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDWP-DAGR
MMAR_0101|M.marinum_M               AGVIKMVQAMRHELMPATLHVDVPSPHVDWSSGAVSLLTQPRPWPAVDGR
Rv2048c|M.tuberculosis_H37Rv        AGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP-AGAR
MAV_2450|M.avium_104                AGVIKMVLAMRHELLPATLHVDEPSPHVDWSAGAVSLLTEAQPWP-G-ER
TH_2454|M.thermoresistible__bu      VGLIKAALALQHGVIPPTAGIRELTPAVDWATNGLHVPTTVEPFPRRADS
                                    .*:** . ::::  :* :  .   :  : * :  : :      :      

MAB_0939|M.abscessus_ATCC_1997      PRRAGVSSFGFTGTNAHVLIEEAPQPQATP----------DEDDASTPQS
Mvan_0269|M.vanbaalenii_PYR-1       PRRAGVSSFGFTGTNAHVLIEEAPLPQAAD----------PVEEPDT-RA
Mflv_0405|M.gilvum_PYR-GCK          PRRAGVSSFGFTGTNAHVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAP
MSMEG_0408|M.smegmatis_MC2_155      VRRAGVSSFGFTGTNAHVLVEEAPPQLHTADAAP----VEPAATAEAGTD
Mb2971c|M.bovis_AF2122/97           PRRAAVSSFGISGTNAHLILEEAPVPAPA------EAPVEASESTGGP-R
MLBr_00135|M.leprae_Br4923          PRRAGVSSFGISGTNAHVILEEAPT------------PVEASYSTADQQR
MUL_2005|M.ulcerans_Agy99           PRRAGVSSFGISGTNAHVILEEAPAP----------EAVPDSESNKGEPS
MMAR_0101|M.marinum_M               PRRAGVSSFGISGTNAHVIVEQVCP---------------EVVAEAVDVS
Rv2048c|M.tuberculosis_H37Rv        TRRAGVSSFGISGTNAHVIIEAVP----------------VVPRREAGWA
MAV_2450|M.avium_104                PRRAGVSSFGISGTNAHVIIEAVPA---------------VEPAHADAPA
TH_2454|M.thermoresistible__bu      PRRAAVCSYGYGGTIAHLLLEEAPAVDETP-----AAAPAPAADAADANS
                                     ***.*.*:*  ** **:::* .                           

MAB_0939|M.abscessus_ATCC_1997      APVSVLPLSARSPEALAAVAQRYESWLAAHPDVDLEDVCLTAGRGRSHFE
Mvan_0269|M.vanbaalenii_PYR-1       LPVGVLALSARSPEALTALAQRYEAWLSAHPDADLADVCRTAGTGRSHFE
Mflv_0405|M.gilvum_PYR-GCK          APVEVLPLSARSPEALVALAQRYETWLTAHPEADLADVCRTAGTGRSHFE
MSMEG_0408|M.smegmatis_MC2_155      DSPQVLALSARSPEALVELARRYDDWLSATPGLDIADVCHTAGVGRSHFE
Mb2971c|M.bovis_AF2122/97           PSMVPWVISARSAEALTAQAGRLMAHVQANPGLDPIDVG-CSLASRSVFE
MLBr_00135|M.leprae_Br4923          LSVVPWVVSGRSTAALMAQASRLAFYVQADPEVDPVDVG-CALAARSVFE
MUL_2005|M.ulcerans_Agy99           LPVVPWVISARSAEALTAQAGRLLAHVQADPQSNPVDIG-FSLAGRSAFE
MMAR_0101|M.marinum_M               PDSLPWVVSGKSEAAVAAQAKRLLAAVQADEGLDRLDVG-FSLARRTAFE
Rv2048c|M.tuberculosis_H37Rv        GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVG-WSLAGRSVFE
MAV_2450|M.avium_104                LPVLPWVVSAKSAAALRAQAARLAEYVRAQGELDIADVG-WTLAGRATFE
TH_2454|M.thermoresistible__bu      PRFHVIPVSARSGARLARHAAALRGHLSAGADLTAVAAT-MWQR-RSHEP
                                           :*.:*   :   *      : .                *:   

MAB_0939|M.abscessus_ATCC_1997      HRAALVVDSIQTAREGLLELAQNRLRPGVVRGEHTNHPTT--AWLFTGQG
Mvan_0269|M.vanbaalenii_PYR-1       HRAALVVDSVAAAREGLAELAQNRLRPGVVRGEHTHHPTT--AWLFTGQG
Mflv_0405|M.gilvum_PYR-GCK          HRAALVVDSVESARIALTDLAQNRLRPGVVRGEHLNHPTT--AWMFTGQG
MSMEG_0408|M.smegmatis_MC2_155      YRAALVVDSVERAREGLAALAEGRTPAGVVRGEHVHRPTT--AWLFTGQG
Mb2971c|M.bovis_AF2122/97           HRAVVVGASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKT--VVVFPGQG
MLBr_00135|M.leprae_Br4923          HRAVVVGESREQLIAGLAGLAVGESGAGVAIGQAAPLGKT--VVVFPGQG
MUL_2005|M.ulcerans_Agy99           HRAVVVGADRQQLLTGLATLADGAPGAGVVTGQAGSVGKT--AVVFPGQG
MMAR_0101|M.marinum_M               YRAVVLGEDRQQLISGLTELAAGQPGPTVLNGRAATVSKT--VMVFPGQG
Rv2048c|M.tuberculosis_H37Rv        HRAVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKT--VFVFPGQG
MAV_2450|M.avium_104                HRAVVVGGDRDRLLAGLDELAADDPAASIIRGVATPAGKT--VFVFPGQG
TH_2454|M.thermoresistible__bu      VRAAVIARHPGELVAGLDAIATDTRHPAVVAGSVLPAAEAGAVWVFSGHG
                                     **.::         .*  :* .     :  *       :  . :*.*:*

MAB_0939|M.abscessus_ATCC_1997      SQYPGMARELFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGK
Mvan_0269|M.vanbaalenii_PYR-1       SQFPGMARELFETEPVFADAVTRCADAVKDILPRPLLEVLFAADRESG--
Mflv_0405|M.gilvum_PYR-GCK          SQYPGMARELFDTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVP
MSMEG_0408|M.smegmatis_MC2_155      SQYPGMARELFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRETA--
Mb2971c|M.bovis_AF2122/97           AQRIGMGRELYGELPVFAQAFDAVADELDRHLRLPLRDVIWGADA-----
MLBr_00135|M.leprae_Br4923          AQRIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGADA-----
MUL_2005|M.ulcerans_Agy99           SQRIGMARELHDQLPVFAEAFDAVADELDRHLRIPLCEVMWGSDV-----
MMAR_0101|M.marinum_M               SQRLGMGQQLHGQFPVFAQAFDAVVEQLDRYLRLPLRDALWGGDE-----
Rv2048c|M.tuberculosis_H37Rv        SQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGHDE-----
MAV_2450|M.avium_104                SQTLGMGRQLHAGYPVFAEAFDAVVAELDRHLLRPLRDVIWGDDE-----
TH_2454|M.thermoresistible__bu      SHWPGMGRELLEHEPVFAAVIDEIEPVFRAELGFSPRQALQSGE------
                                    ::  **.  *    ****  .      .   :  .  :.: .        

MAB_0939|M.abscessus_ATCC_1997      AGEALRHTSFAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVA
Mvan_0269|M.vanbaalenii_PYR-1       --EALRHTSFAQPAIFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVA
Mflv_0405|M.gilvum_PYR-GCK          PTETLRHTSFAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVA
MSMEG_0408|M.smegmatis_MC2_155      --DLLQHTSFAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVA
Mb2971c|M.bovis_AF2122/97           --DLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAA
MLBr_00135|M.leprae_Br4923          --GLLDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVA
MUL_2005|M.ulcerans_Agy99           --ALLDSTEFAQAALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVA
MMAR_0101|M.marinum_M               --HLLESTEFAQPSLFAVEVALFALLRDWGVSPDVVMGHSVGELSAAHVA
Rv2048c|M.tuberculosis_H37Rv        --NLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVA
MAV_2450|M.avium_104                --NVLNSTEFAQPALFAVEVALFRLLESWGVRPDFVMGHSIGELSAAHVA
TH_2454|M.thermoresistible__bu      ----LGGTDRVQALTFAVQAGLAAVLRDRGVKPAAVIGHSVGEVAACVAA
                                        *  *. .*.  ***: .        .: *  *:***:*: :*. .*

MAB_0939|M.abscessus_ATCC_1997      GVFSIEDGARLIAERGRLFGGLPAGGRMVAVFSDAKHVEQIAGEFPRVSV
Mvan_0269|M.vanbaalenii_PYR-1       GVFSLEDGARLMAERGRMFGSLPEGGRMVAVFTDAKLVEEIAGDFPRVSV
Mflv_0405|M.gilvum_PYR-GCK          GVFSLEDGARLMAERGRLFGSLPEGGRMVAVFADAKRVEQVAADFPRVSV
MSMEG_0408|M.smegmatis_MC2_155      GVFSLDDGARLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEFPRVSV
Mb2971c|M.bovis_AF2122/97           GVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAA
MLBr_00135|M.leprae_Br4923          GVLAPADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEGVGIAA
MUL_2005|M.ulcerans_Agy99           GVLTLVDAAMLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDGVGIAA
MMAR_0101|M.marinum_M               GVLTLDDAAKLVAARGRLMQALPEGGAMFAIAASEHEVSPLLGEAVGIAA
Rv2048c|M.tuberculosis_H37Rv        GVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAA
MAV_2450|M.avium_104                GVLSLQNAAVLVAARGRFMQALPEGGAMIAVQATEAQVRPLLGPDVGIAA
TH_2454|M.thermoresistible__bu      GVFDLARGAAVACYRARGFRSVAGKGAMALVGLPFEDARQRLGERTDVVA
                                    **:    .* :   *.* : .:.  * *  :      .         : .

MAB_0939|M.abscessus_ATCC_1997      GAY-NGPNTVLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDPIL
Mvan_0269|M.vanbaalenii_PYR-1       GAY-NGPNTVLSGPGEDLEQIVDRFGDDGVRCTWLQTSHAFHSELLDPVL
Mflv_0405|M.gilvum_PYR-GCK          GAY-NGPNTVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVL
MSMEG_0408|M.smegmatis_MC2_155      GAY-NGPNTVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVL
Mb2971c|M.bovis_AF2122/97           IN--APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPML
MLBr_00135|M.leprae_Br4923          IN--APESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPML
MUL_2005|M.ulcerans_Agy99           IN--APKSVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPML
MMAR_0101|M.marinum_M               IN--APDAVVISGERAAVGVLAEELIDRGRRVHRLAVSHAFHSPLMEPML
Rv2048c|M.tuberculosis_H37Rv        VN--GPASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMI
MAV_2450|M.avium_104                VN--GPAAVVISGDHDAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMI
TH_2454|M.thermoresistible__bu      AISASPLSTVISGTVDAVGEVSAAWAEQGVMVRKVNTDVAFHSPAMDALT
                                             *:**               *     : .. ****  ::.: 

MAB_0939|M.abscessus_ATCC_1997      DEFESYAAQVQFAAPTLPLVCNRTGAVLTAQT-PIDGQYWRRHSRQPVQF
Mvan_0269|M.vanbaalenii_PYR-1       DEFESYAAQFQFATPTLPLVCNRTGTVLTAQT-PLDAQYWRRHSRQPVQF
Mflv_0405|M.gilvum_PYR-GCK          DEFESYAAQLQFAAPTLPLVCNRTGAVLTGQT-SLDAQYWRRHSRQPVQF
MSMEG_0408|M.smegmatis_MC2_155      DEFEAYAAQFQFAAPTLPLVCNRTGAVLTGQT-PLDAQYWRRHSRQPVQF
Mb2971c|M.bovis_AF2122/97           EEFARVAARVQAREPQLGLVSNVTGELAGPD--FGSAQYWVDHVRRPVRF
MLBr_00135|M.leprae_Br4923          EEFVRVAAQVEVRKPQIGLVSNVTGELAGPD--FGSPQYWGEHVSRAVRF
MUL_2005|M.ulcerans_Agy99           EEFARIAAQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAVRF
MMAR_0101|M.marinum_M               ADFALAAGDITAHPPRIALVSNLTGELAGPD--YGSAQYWVEHVRRPVRF
Rv2048c|M.tuberculosis_H37Rv        DEFAAVAAGIAIGRPTIGVISNVTGQLAGDD--FGSAAYWRRHIRQAVRF
MAV_2450|M.avium_104                DEFGTVAAGLAIDKPVIPIISNLTGQPAADD--FGSPEYWKCHVRDAVRF
TH_2454|M.thermoresistible__bu      AELARLTSTLTPKPAAVPLYSTALADPRSTA--ARDEHYWVANLRGRVRF
                                     ::   :. .    . : : ..  .          .  **  :    *:*

MAB_0939|M.abscessus_ATCC_1997      AESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAPP-RAIVSLRKGV
Mvan_0269|M.vanbaalenii_PYR-1       AESVRTVAALGCSVLMEIGPQPVLTGSAVQVWPEHLAAP-RAIVSLRKGV
Mflv_0405|M.gilvum_PYR-GCK          AESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAAP-RAIASLRKGV
MSMEG_0408|M.smegmatis_MC2_155      AESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHMAAP-RAVASLRKGV
Mb2971c|M.bovis_AF2122/97           ADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAPAEA---MVVSMLGKDR
MLBr_00135|M.leprae_Br4923          VDSARHLQTLGATHFIESGPSSGLMGAIEQSLAPAEA---VVVSMMGKDR
MUL_2005|M.ulcerans_Agy99           ADSARQLHTLGVTHFVEVGPGSGLTGSIEQSLAPAEA---VVVSMLGKDR
MMAR_0101|M.marinum_M               ADSVRNLEELGASHFIEVGPGGGLSSAIAQSLRSPEA---VTVPVLGKDR
Rv2048c|M.tuberculosis_H37Rv        ADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAV---TTMSALRKDR
MAV_2450|M.avium_104                ADSVRFAQSAGATRFLEVGPSSGLTAAIEETLADAPV---VTVSALRKDR
TH_2454|M.thermoresistible__bu      AEAVTAAAEDGHRLFLEVSAHPVVCHSMAETLALAEVGEHAVLPVLRREQ
                                    .::.      *   ::* ..   :  :  :      .    .:  : :  

MAB_0939|M.abscessus_ATCC_1997      EDRRQIADALASAYVSGHRPNFAALQR-HPRRTVELPTYPFQRRRFWPK-
Mvan_0269|M.vanbaalenii_PYR-1       SDRRQITEALAAAYVGGHRPDFGALYR-RPGRAVALPTYPFQRRRFWPK-
Mflv_0405|M.gilvum_PYR-GCK          ADRRQIADALAAAYIGGHKPDFAALHE-QRGVRLELPTYPFQRRRFWPK-
MSMEG_0408|M.smegmatis_MC2_155      ADRRQIADALASAYVGGHRPDFAAVHR-QPRRPVELPTYPFQRRRFWPK-
Mb2971c|M.bovis_AF2122/97           PELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETP
MLBr_00135|M.leprae_Br4923          PELASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETP
MUL_2005|M.ulcerans_Agy99           PEVASVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRRFWEVP
MMAR_0101|M.marinum_M               PEVNSLISAVGQLFSTGVGVDWSAVFAGSGGRQVGLPTYAFARRRFWLD-
Rv2048c|M.tuberculosis_H37Rv        PEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRFWLS-
MAV_2450|M.avium_104                PEPVALVNAVAQGWVCGMDVDWRGALG--TGHLVDLPTYAFDRRRFWLS-
TH_2454|M.thermoresistible__bu      PELPAVAAVVGALYCHGAPVRP--AFPPGTRWATGLPGTQWQHRRFWRT-
                                     :      . .  :  *                  **   : :****   

MAB_0939|M.abscessus_ATCC_1997      --SSGTAIEGGGGLPSG--ILGRGED-LASGDSVYISRLSVRSQPWLSDH
Mvan_0269|M.vanbaalenii_PYR-1       --TSGITTDG--PAVSG--ILGSAKD-LASGDTVYTSRWSVRSQPWLADH
Mflv_0405|M.gilvum_PYR-GCK          --SAGMAIDGRVGASAGSGILGSGKD-LASGDSVYTSRLSVKTQPWLSDH
MSMEG_0408|M.smegmatis_MC2_155      --ASSIAVDGG-TAASG--ILGSGKD-LASGDTIYTSRLSVKSQPWLADH
Mb2971c|M.bovis_AF2122/97           GADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADH
MLBr_00135|M.leprae_Br4923          GTDGTASVSGLGLGSTEHALLGAVVERPDSGGVVLTGRLSLANQPWLADH
MUL_2005|M.ulcerans_Agy99           GADGPADATGLGLGGAEHALLGAVVERPDSGGVVLTGRLALADQPWLADH
MMAR_0101|M.marinum_M               GSASAADVGEAGLVAAGHALLGAVVEQPDTGAVVLTGRLSLARQPWLADH
Rv2048c|M.tuberculosis_H37Rv        GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADH
MAV_2450|M.avium_104                GDGAASDAAGLGLAAGDHALLGAVVELPASGGVLLTGRLSPASQGWLADH
TH_2454|M.thermoresistible__bu      -PGTPPGGVGVHDVDSHTLLGGRIDVAGAVPARVWQTRLDLSTRPYPGDH
                                                       : *           :   *     : : .**

MAB_0939|M.abscessus_ATCC_1997      VIYGTVVVPGATYAAMALAAVG--------------------TPARAKDV
Mvan_0269|M.vanbaalenii_PYR-1       VIYGTVVVPGATYAAMALAAVG--------------------TPARVKDV
Mflv_0405|M.gilvum_PYR-GCK          VIYGTVVVPGATYAAMALAAVG--------------------TPAHAKDV
MSMEG_0408|M.smegmatis_MC2_155      VIYGTVVVPGATYAAMALAAVG--------------------TPARLKDV
Mb2971c|M.bovis_AF2122/97           VVNGVVLFPGAGFVELVIRAG------------------DEVGCALIEEL
MLBr_00135|M.leprae_Br4923          VIGGVVLFPGAGFVELVIRAG------------------DEVGCAGVEEL
MUL_2005|M.ulcerans_Agy99           VIGGVVLFPGAGFVELAIRAG------------------DEVGCAVVEEL
MMAR_0101|M.marinum_M               LVGGAVLFPGTGFVELAIRAG------------------DEVGCGVVEEL
Rv2048c|M.tuberculosis_H37Rv        SVAGVTIFPGAGFVELAIRAG------------------DEVGCGVVDES
MAV_2450|M.avium_104                AVGGVVLFPGAGFVELAIRAG------------------DEVGCGIIDEL
TH_2454|M.thermoresistible__bu      PVQGTEIVPAAVLLNTFLTAAGSDIADVRLRTPVAPARTRDVQVVLQDRA
                                     : *. :.*.:      : *                           .  

MAB_0939|M.abscessus_ATCC_1997      FFYEPIILPEKSSREVQLTLHPLEDGSGSKFQVHSRPYGERDVDWSLNAE
Mvan_0269|M.vanbaalenii_PYR-1       FFYEPIILPEKASREVQLTLHPSEDG-GQKFQVHSREYGERGTEWSLNAE
Mflv_0405|M.gilvum_PYR-GCK          FFYEPIILPEKSSREVQLTVHPSVDG-ESKFQVHSRPYGERGAEWALNAE
MSMEG_0408|M.smegmatis_MC2_155      FFYEPIILPEKASREVQLTLHPADGGSVLSFQIHSRPYGERGADWSLNAE
Mb2971c|M.bovis_AF2122/97           VLAAPLVMHPGVGVQVQVVVGAADESGHRAVSVYSRGD-QSQG-WLLNAE
MLBr_00135|M.leprae_Br4923          VLAAPLVLHPGSGVQVQVVVAAADESSRRAVSVYSRGD-QSHGGWLLNAE
MUL_2005|M.ulcerans_Agy99           VLAAPLVLHPGMGVQVQVIVGTADDSGNRALSVYSRGD-KSED-WLLNAE
MMAR_0101|M.marinum_M               TLATPLVLNAGTAVQVQVVVGSAGQSGQRLVSMYSRAD-QPDQHWVLHAQ
Rv2048c|M.tuberculosis_H37Rv        TLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRGD-VGTG-WVLHAE
MAV_2450|M.avium_104                NLAAPLVLPAGGSVAIQVVVDGPDDSGARAVSVFSRAD-AGAG-WLLHAE
TH_2454|M.thermoresistible__bu      LALASRIVGEDTTARATAGRDTTDRDTTACDTTDRDTT-ACDDPGVWLTH
                                        . ::                 .                      :.

MAB_0939|M.abscessus_ATCC_1997      GTVVTGIGDDAEPAPEAAEPAEPVDAAIERMERMRPMELFEIFADLELAW
Mvan_0269|M.vanbaalenii_PYR-1       GTVASGVDENPQ-----AEPSGPVDEAIERLNRMRPQDLFETFADMELAW
Mflv_0405|M.gilvum_PYR-GCK          GVVASGVGDSPAAAG---DLEDPVDEAIERLNRMRPQELFETFADLELAW
MSMEG_0408|M.smegmatis_MC2_155      GTVDTAGSDPDAAAD---EQSDPVDEVIERLERMRPQDLFETFADLELAW
Mb2971c|M.bovis_AF2122/97           GMLG----VAAAETP-----MDLSVWPPEGAESVDISDGYAQLAERGYAY
MLBr_00135|M.leprae_Br4923          GLLE----VDAAEAT-----VDLSLWPPEGAESVDISDAYPQLAERGYAY
MUL_2005|M.ulcerans_Agy99           GMLG----VEAASSG-----ADLSVWPPEGAESVDISDGYAQLADRGYAY
MMAR_0101|M.marinum_M               GSVAPAAVQPAAAAS-----AELSTWPPAGAEAVDIGGLYERLARRGYGY
Rv2048c|M.tuberculosis_H37Rv        GALR----AGSAEPT-----ADLAMWPPAGAVPVEVADGYQQLAERGYGY
MAV_2450|M.avium_104                GVLR----AGSAQPA-----TDLSAWPPVGAVPVDLGDGYEQLAERGYRY
TH_2454|M.thermoresistible__bu      CTARVADDHVGAEGV-----LDEEAIRARCPQPLPAGHVVDTLAGLGVAA
                                                                     :        :*      

MAB_0939|M.abscessus_ATCC_1997      GPTWSGSLKSLWLGEGEAIGDVLVGEELAEQLGTEPMHPVLMDLCTGVAF
Mvan_0269|M.vanbaalenii_PYR-1       GPTWSGSLKSLWLGEGEAIGDILVGEELAEQLGTEPMHPVLMDLCTGVAF
Mflv_0405|M.gilvum_PYR-GCK          GPTWSGSLKSLWLGEGEAIGDILVGAELAEQLGTEPMHPVLMDLCTGVAF
MSMEG_0408|M.smegmatis_MC2_155      GPTWSGSLKSLWLGDGEAVGDILVGAELAEQLGSEPMHPVLMDLCTGVAF
Mb2971c|M.bovis_AF2122/97           GPAFQG-LVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALG
MLBr_00135|M.leprae_Br4923          GPAFQG-LVAIWRRGSELFAEVVAP--TGVVVDGMGMHPALLDAVLHALG
MUL_2005|M.ulcerans_Agy99           GPGFQG-LVGVWRRDSELFAEVVAP--SGVAVDKMGMHPVVLDAVLHALG
MMAR_0101|M.marinum_M               GPAFQG-LRAVWRRGRDVFAEVGLPNDEGLDLTDVGIHPALLDAVLHATM
Rv2048c|M.tuberculosis_H37Rv        GPAFRG-LTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVV
MAV_2450|M.avium_104                GPAFRG-LTSMWRRGDEIFAEVNLPTDAGVSTTGFGVHPVMLDAALHAVM
TH_2454|M.thermoresistible__bu      MGFGWE-VLELHRGEGELFARVAAE--------PDKSAPATWAGLIDAAT
                                           :  :     : .. :                *.       .  

MAB_0939|M.abscessus_ATCC_1997      PAFPALLAAEQGVNDLFLPLRYGQVTLKEKMPRRFYCRARWHESPLDSET
Mvan_0269|M.vanbaalenii_PYR-1       PAFPALLAAEQGVSDLFLPLRYGQVTLRDKMPRRFYCRATWHTSELDSET
Mflv_0405|M.gilvum_PYR-GCK          PAFPALLAAEQGVNDLYLPLRYGQVSLQEKMPRRFYCRATWHEAPLDSET
MSMEG_0408|M.smegmatis_MC2_155      PAFPALLAAEQGVNDLFLPLRYGQVTLAEKMPRRFYCRARWHRSALDSET
Mb2971c|M.bovis_AF2122/97           ---LAVEKTQASTE-TRLPFCWRGVSLHAGGAGRVRARFASA-GAD--AI
MLBr_00135|M.leprae_Br4923          ---LAIENTQATTE-MRLPFCWRGVSLHAGGAGRVRARFTSA-GAD--AI
MUL_2005|M.ulcerans_Agy99           ---LTAEQNPDSDE-TKLPFCWRGVSLHAGGAGRVRARLTMS-GPD--SI
MMAR_0101|M.marinum_M               ---AAAG--ADVAE-MRLPFSWRGVSLHAAGAAGLRARIAALDGGDGAAV
Rv2048c|M.tuberculosis_H37Rv        ---LSAESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPS---AV
MAV_2450|M.avium_104                ---LASDGDDLPAGSMLVPFSWQRVSLHAAGAAAVRARIVPVSPS---AV
TH_2454|M.thermoresistible__bu      ---STASTIFDGPPRLRMPARIERVHVRDKPPAIALLHVRRRPEGT--VT
                                        :            :*     * :    .     :            

MAB_0939|M.abscessus_ATCC_1997      QVFDLDYLDRDGRHLGGIREFTVKRAPREALLRGLGG-DATRLLYTLGWH
Mvan_0269|M.vanbaalenii_PYR-1       QVFDLDFLDRDGRHLGGIREFTVKRAPREALLRGLGG-DATRLLYTLGWH
Mflv_0405|M.gilvum_PYR-GCK          QVFDLEYLDRDGRHLGGVREFTVKRAPREALLRGLGG-DATRLLYTLGWH
MSMEG_0408|M.smegmatis_MC2_155      QVFELEFVDLGGRALGGIREFTVKRAPREALLRGLGG-DATRLLYTLGWH
Mb2971c|M.bovis_AF2122/97           SVDVCDATGLPVLTVRSLVTRPITAEQLRAAVTAAGG-ASDQGPLEVVWS
MLBr_00135|M.leprae_Br4923          AVDIADSAGLPVLTVRSLVTRAMTAEQLRTAVTAAGG-ALEQGPMDLVWS
MUL_2005|M.ulcerans_Agy99           SVEIADAAGLPVLTVGALVTRAMSAAQLRAAVAEAGGGAPDQGPLDVIWS
MMAR_0101|M.marinum_M               SVELADAAGLPVLSVDSLVTRPVTANQLNAAIAAAAG-APDDKLLEVAWS
Rv2048c|M.tuberculosis_H37Rv        SIELADGLGLPVLSVASMLARPVTDQQLRAAVSSSGP----DRLFEVTWS
MAV_2450|M.avium_104                SIELADGLGLPVLSVASMVARPVTDQQLLAAVSNSGP----DRLFELIWS
TH_2454|M.thermoresistible__bu      DVTIAEESGAVSVTLTGMGFEELENPGGGGSSGDLTGMLHHLRWHPVDWP
                                     :   :  .     : .:    :                       : * 

MAB_0939|M.abscessus_ATCC_1997      EVAVPPVAGEGEESAASIGTWLIAGFDELAAKVPGCIPLNRETDPELLGE
Mvan_0269|M.vanbaalenii_PYR-1       EVPAPASG-----DAALNGNWLIAGFDELAAGVPGCIPFDRSTDPEPLGQ
Mflv_0405|M.gilvum_PYR-GCK          EVPVPESG----DGAAPQGTWLIGGFDELAVSVPGCIPADR-TNPESLRQ
MSMEG_0408|M.smegmatis_MC2_155      EVPPPPSA------DDAVGTWLIAGFDELAAKVPGCVPIDRNTDLQVLGE
Mb2971c|M.bovis_AF2122/97           PISVVSGG--------------ANGSAPPAPVSWADFCAGSDG-------
MLBr_00135|M.leprae_Br4923          PIPLSSDG--------------HGG-GLPSVVSWADYCAGRGN-------
MUL_2005|M.ulcerans_Agy99           PIPLSGSG--------------TNGSAQPAVVSWADFCAGGDGGAA----
MMAR_0101|M.marinum_M               PIALNDRT--------------IGGRDDVPVMLWDDHRDDDGHG------
Rv2048c|M.tuberculosis_H37Rv        PQPS-------------------AAVEPLPVCAWGTTEDSA---------
MAV_2450|M.avium_104                AQPS-------------------TAVQPVSLLNWGATELDATDTDSD---
TH_2454|M.thermoresistible__bu      DTDPPAAV--------------VLVGGDARTRAFVTRDLDEARVAHRS--
                                                                           .          

MAB_0939|M.abscessus_ATCC_1997      VLVAAKERGVPFSGVVWRAAGPGATES--TTESAARLEGEIAHLLSAVHT
Mvan_0269|M.vanbaalenii_PYR-1       LLAQAHERGIGFSGVVWRAAAPSADES--STAMAARIETEIADLLSAVHT
Mflv_0405|M.gilvum_PYR-GCK          LLTDAHGRGLPFSGVVWRAARSDGDES--DAEVAARLEAEIAELLGAVHT
MSMEG_0408|M.smegmatis_MC2_155      VLSQAHARGAGFSGVVWRCATPGRKESGSASAESARLEAEITNLLSAVHA
Mb2971c|M.bovis_AF2122/97           -----------DASVVVWELESAGGQASS---VVGSVYAATHTALEVLQS
MLBr_00135|M.leprae_Br4923          -----------DTGVVVWEFGSASAGAQAPVDSVAAVYSATHAALQVLQF
MUL_2005|M.ulcerans_Agy99           ----------GDAGVVVWEPNPAG------EDVVGPVYAATHAALEVLQS
MMAR_0101|M.marinum_M               -----------AGTVVIWESCCAADD-----DVVRSAYAATHAALAVLQS
Rv2048c|M.tuberculosis_H37Rv        --------------AVVFESVPLAG------DVVAGVYAATSSVLDVLQS
MAV_2450|M.avium_104                ----------SGRFAVLFESAPVAG------DVVTEVYAATRAVLPVLQS
TH_2454|M.thermoresistible__bu      ----------YADPAALPPDLTAGTVVLVLPRTAARPAASAQLVLHTLQR
                                                  ..                            * .:: 

MAB_0939|M.abscessus_ATCC_1997      VQNSAQNGVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTTINEEP
Mvan_0269|M.vanbaalenii_PYR-1       VQN---GAVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTTINEEP
Mflv_0405|M.gilvum_PYR-GCK          VQG---GEVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTAINEEP
MSMEG_0408|M.smegmatis_MC2_155      AQG---PSVKLPGGLWIVTEHGVACESGEPVDPVQAALWGFGRTTINEEP
Mb2971c|M.bovis_AF2122/97           WLG-----ADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENP
MLBr_00135|M.leprae_Br4923          WFG-----QDRAGTLVVLTRGAVGLVGEGISDLAAAAVWGMVRSAQSEHS
MUL_2005|M.ulcerans_Agy99           WFD-----GDRAGTLVVLTHGAVAMPGENVSDLAGAAVWGIVRSAQAENP
MMAR_0101|M.marinum_M               WLS-----GDRPGTLVIVTHGGVALTDEGVKDLAAAAVWGLVRSAQSEHP
Rv2048c|M.tuberculosis_H37Rv        WLT-----RDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHP
MAV_2450|M.avium_104                WLA-----RDGAGTLVVSTRGAMTLPGEDVTDLAGAAVWGLVRSAQTEHP
TH_2454|M.thermoresistible__bu      LSA-----TNSGARLWVLTRGVHEG-----TDPGHGPLWGLARVAAAEHP
                                             .  . * : *.           *   ..:**: * :  *..

MAB_0939|M.abscessus_ATCC_1997      ALRAKLVDGDGSPEAVQALARLLVTP-VDEPEIAVRQGKLLASRLLPWSR
Mvan_0269|M.vanbaalenii_PYR-1       ALRCRLVDVDGSPEAVLALAGLLAAP-VDEPELAVRQGKLLASRLLPWAR
Mflv_0405|M.gilvum_PYR-GCK          ALRCRLVDCDGSPQAVQALAALLSTP-VDEPELAVRQGKLLASRLLPWSR
MSMEG_0408|M.smegmatis_MC2_155      ALHCRLVDCDGSSEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLLPWAR
Mb2971c|M.bovis_AF2122/97           GR-IVLIDTDAA-------VDASVLAGVGEPQLLVRGGTVHAPRLS--PA
MLBr_00135|M.leprae_Br4923          GK-IVLIDTDSA-------VDVAVLADLGESQLLVRCNTVHAARLS--PA
MUL_2005|M.ulcerans_Agy99           GR-IVLVDADAA-------VEAAELVAVGEPQLVVRSGAAHAARLA--PA
MMAR_0101|M.marinum_M               GR-IVLIDTDSAPTDPEVLMDLANLAGRGEPQLLVSGGAVYGARLA--PI
Rv2048c|M.tuberculosis_H37Rv        GR-IVLVDSDAP----LDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRA
MAV_2450|M.avium_104                GR-IVLVDTDAP----LDADAVAAVLAVGEPQTLLRNGTVYTARVLGSRA
TH_2454|M.thermoresistible__bu      QL-WGGLLDIGE----DRLPVRALTALTGHGVVVVRDGVAHTARLA--PA
                                          :   .                  .       .    .*:     

MAB_0939|M.abscessus_ATCC_1997      TGHLTVPRGSDYVLAPTERGAIDN---LRITEKEVPAPDEGYVQVRVEAA
Mvan_0269|M.vanbaalenii_PYR-1       SGHLTVPRSADYVLAPTERGAIDN---LRLTETDVAPPAEGYVQVRVEAA
Mflv_0405|M.gilvum_PYR-GCK          SGHLTVPRGGDYVLAPTERGAIDN---LRLTDSEVPPPAEGYVQVRVEAA
MSMEG_0408|M.smegmatis_MC2_155      SGHLTLPRGGDFVLAPTERGAIDN---LRLTETDVPEPDEGYVQVRVEAA
Mb2971c|M.bovis_AF2122/97           PALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAV
MLBr_00135|M.leprae_Br4923          PQLLALPVGESMWRLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAV
MUL_2005|M.ulcerans_Agy99           APLLAVPADESAWRLAAGGGGTLEDLVIEPCPEVQAPLAAGQVRVAVRAV
MMAR_0101|M.marinum_M               PPALSATDGD--------------------CPTSDGPAEL----------
Rv2048c|M.tuberculosis_H37Rv        VGGLLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAI
MAV_2450|M.avium_104                VGALLVPPEDGPWRLGMSSYGTIENLRLEPIPDADAPLGPGQVRVATSAL
TH_2454|M.thermoresistible__bu      GPGARDSAGEGLRCSPGG--------------------------------
                                          .                                           

MAB_0939|M.abscessus_ATCC_1997      GLNFRDVLNVLGLYPGDPGPIGGDFAGIVTQLGEGVTGVEVGQRVYGSMQ
Mvan_0269|M.vanbaalenii_PYR-1       GLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGSGVTGLEVGQRVYGFMQ
Mflv_0405|M.gilvum_PYR-GCK          GLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQ
MSMEG_0408|M.smegmatis_MC2_155      GLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGAGVSGLEIGQRVYGSMQ
Mb2971c|M.bovis_AF2122/97           GVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-
MLBr_00135|M.leprae_Br4923          GVNFRDVVAALGMYPGQAPPLGAEGAGVVIEIGPEVTGVAVGDAVMGFL-
MUL_2005|M.ulcerans_Agy99           GVNFRDVVAALGMYPGAAPPLGAEGAGVVLEVGPQVSGVAVGDSVMGFL-
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        AANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFP
MAV_2450|M.avium_104                AANFRDVMIALGLYPDPDAVMGIEASGVVIETASQDGRVAVGDRVMGLFP
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      GAFGSRFNVPAQFLAPIPDGISGVEAATIPAAALTVR-LSFDWAQLKPGD
Mvan_0269|M.vanbaalenii_PYR-1       GAFASRFNVPAQLLAPIPDGIGAVDAATIPAAALTAR-LAFDWAQLKPGD
Mflv_0405|M.gilvum_PYR-GCK          GAFASRFNVPGQFLAPIPDGVSAVEAATIPAAALTVR-LSFDWAQVKSGD
MSMEG_0408|M.smegmatis_MC2_155      GAFASRFNVPAQFLAPIPDGIGAVEAATIPAAALTVR-LAFDWAQLKPGD
Mb2971c|M.bovis_AF2122/97           GGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGE
MLBr_00135|M.leprae_Br4923          GGAGPLAVVHQQLITQMPQGWSLAEAAAVPVVFLTALFGLADLAGIRAGE
MUL_2005|M.ulcerans_Agy99           GGAGPLSVVDQQLITRMPQGWSFAQAAAVPVVFLTALFGLQDLAKIQPGE
MMAR_0101|M.marinum_M               -------------------------------------------------A
Rv2048c|M.tuberculosis_H37Rv        EGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARSGQ
MAV_2450|M.avium_104                DGTGTVATTDQRLLVKVPAGWSHTAAATASVVFATAYYALVDLADARPGQ
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      KVLIHAASGGVGLAAIQMAQQFGAEVFATASTFKRATLRKLG--VKYVYD
Mvan_0269|M.vanbaalenii_PYR-1       RVLIHAASGGVGLAAIQMAQQHGAVVFATASTYKRATLRKLG--VDHVYD
Mflv_0405|M.gilvum_PYR-GCK          KVLIHAASGGVGLAAVQMAQQCGAEVYATASTFKRATLRKLG--VKHVYD
MSMEG_0408|M.smegmatis_MC2_155      KVLIHAASGGVGLAAIQMAQQSGAEVFATASTFKRSTLRRLG--VKYVYD
Mb2971c|M.bovis_AF2122/97           SVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGD
MLBr_00135|M.leprae_Br4923          SVLIHAGTGGVGMAAVQFARHWGVEIFVTASRGKWDTLRDMGFDDDHIGD
MUL_2005|M.ulcerans_Agy99           SVLIHAGTGGVGMAAVQLARHWGVEIFVTASRGKWDTLRAMGFDDDHIGD
MMAR_0101|M.marinum_M               SVLDPAGT------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        RVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISD
MAV_2450|M.avium_104                RVLVHAAAGGVGMAAVQLARHLGLEVFATASRGKWDTLRDMGFDDDHLGD
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      SRTTDFADQILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAK
Mvan_0269|M.vanbaalenii_PYR-1       SRTTEFADQILADTDGEGVDVVLNSLTNEGFIEATVRATAQNGRFAEIAK
Mflv_0405|M.gilvum_PYR-GCK          SRTTDFAEQILADTDGAGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAK
MSMEG_0408|M.smegmatis_MC2_155      SRTTDFADQILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAK
Mb2971c|M.bovis_AF2122/97           SRTCEFEEKFLAVTEGRGVDVVLDSLAGE-FVDASLRLLVRGGRFLEMGK
MLBr_00135|M.leprae_Br4923          SRTLEFEEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGK
MUL_2005|M.ulcerans_Agy99           SRTLDFEEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGK
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        SRSLEFEDKFRAATGGRGFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGK
MAV_2450|M.avium_104                SRGLDFEDKFRAVTGGAGMDIVLDSLSGD-SVDASLRLVAPGGIFLEMGK
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      RDIWTTEQMAQSRPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKG--
Mvan_0269|M.vanbaalenii_PYR-1       RDIWTPEQMAAARPDIAYEIVALDTVTLLEPERIRGLLGEVSDGLGKADG
Mflv_0405|M.gilvum_PYR-GCK          RDIWTVEQMAAARPDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDG--
MSMEG_0408|M.smegmatis_MC2_155      RDIWSHEQMAEARPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARG--
Mb2971c|M.bovis_AF2122/97           TDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELH--
MLBr_00135|M.leprae_Br4923          TDIRDAQEIAANYPGVQYRAFDLSEAGPVRMQEMLCEVRELFDTQVLH--
MUL_2005|M.ulcerans_Agy99           TDIRDADKIAANYPGVWYRAFDLSEAGPVRMQEMLAEVRELFDTAVLH--
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        TDIRDPGVIAQQYPGVRYRAFDLFEPGPDRIAQILAELATLFGDGVLR--
MAV_2450|M.avium_104                TDIRDPEVVAAEHPGVRYRAFDLFEAGPDRIARLLDELAAMFGEDVLR--
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      ----EWTPLPAEIYPLTEARTAFRRMQQARHIGKIVCQMPNPLAPR-PDR
Mvan_0269|M.vanbaalenii_PYR-1       SSRAEWVPLPAEIYPLTEARAAFRRMQQARHVGKIVLQMPKPLQPR-ADR
Mflv_0405|M.gilvum_PYR-GCK          ----AWTPLPAEVYPLTEARAAFRRMQQARHIGKIVVQIPNPLQPQ-PDR
MSMEG_0408|M.smegmatis_MC2_155      ----EWTPLPAEIYPITEARSAFRRMQQARHIGKIVLQVPKPLQPQ-QDR
Mb2971c|M.bovis_AF2122/97           -------RLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADG
MLBr_00135|M.leprae_Br4923          -------RLPVTSWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLAEG
MUL_2005|M.ulcerans_Agy99           -------RLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLADA
MMAR_0101|M.marinum_M               --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        -------PLPVTTFDVRCAPAALRYLSQARHTGKVVMLMPGSWAAG----
MAV_2450|M.avium_104                -------PLPVTRFDVRRAPAALRYLSQARHVGKVVMTMPDAWTAG----
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      TYLITGGLGAIG-LHTAAYLAQLGAGDIVLTSRRAPDTDA---------Q
Mvan_0269|M.vanbaalenii_PYR-1       SYLITGGLGAIG-LHTAAYLAQLGAGDLVLTSRRAPDADA---------R
Mflv_0405|M.gilvum_PYR-GCK          SYLITGGLGAIG-LHTAGYLAQLGAGDIVLTSRRAPDAAA---------Q
MSMEG_0408|M.smegmatis_MC2_155      SYLITGGLGAIG-LHTAAYLAQLGAGDIVLTSRRDPDESA---------Q
Mb2971c|M.bovis_AF2122/97           TVVITGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEG---------A
MLBr_00135|M.leprae_Br4923          TVLITGASGAIGGVLARHMVSAYGVRHLVLASRRGDRAEG---------A
MUL_2005|M.ulcerans_Agy99           TVLITGATGAVGAVLARHMLDGYGVRHLVLASRRGDRAEG---------A
MMAR_0101|M.marinum_M               -VLITGGTGMAGGVLARHVVGAGGVRHVVLASRQGEQAPG---------V
Rv2048c|M.tuberculosis_H37Rv        TVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPG---------A
MAV_2450|M.avium_104                TVLITGATGMAGSAVARHVVTRHGARNLVLVSRRGLDAPD---------A
TH_2454|M.thermoresistible__bu      TYLITGGTGALG-LRLAHRLADLGARRLVLVSRSGMPARDSWGRAGDSDT
                                      :***. *  *       :   *.  :**.**                 

MAB_0939|M.abscessus_ATCC_1997      RVIGEITERSKTRIHVFTADVGAESEVAGLLERIRAELPPLAGVAHLAGV
Mvan_0269|M.vanbaalenii_PYR-1       RAIEEITERYKCRVHTFCADVGDESQVAELLARIRAELPPLAGVAHLAGV
Mflv_0405|M.gilvum_PYR-GCK          QAIADIADRTKARLHVFTADVGVEADVAALLERIRAELPPLAGVAHLAGV
MSMEG_0408|M.smegmatis_MC2_155      RAIDEITERHKCRIHTYAADVGDEAQVADLLARIRAELPPLAGIAHLAGV
Mb2971c|M.bovis_AF2122/97           AELAADLTEAGAKGQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGV
MLBr_00135|M.leprae_Br4923          VELAAELVGAGAKIQVVACDVADNDAVRGLFAQLSREFPPVRGVIHAAGV
MUL_2005|M.ulcerans_Agy99           AELAAELSEAGANVQVVACDVADRDAVEAMLARLSGEYPPVRGVIHAAGV
MMAR_0101|M.marinum_M               AELVSELSAAGAEVLVLACDVADRDAVAQMMEQVRRRCPPLTGVIHAAGV
Rv2048c|M.tuberculosis_H37Rv        AELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHP-LSGVIHTAGA
MAV_2450|M.avium_104                AELVAELTAAGAHAEVVACDAADREALAKVIADIPMQHP-LTGVIHAAGV
TH_2454|M.thermoresistible__bu      VAAITALEERGVSVRVAALDIG-APGAAARLREVLADLPDVRGVIHAAGV
                                                   .   * .        :  :    * : *: * **.

MAB_0939|M.abscessus_ATCC_1997      LDDALLGQQSVERFRTTLAPKAFGAEYLDRLTKGDDLDFFIVSSSVSSLF
Mvan_0269|M.vanbaalenii_PYR-1       LDDALLSQQSLERFRTTLAPKAFGACHLDRLTAGDDLDFFIMSSSVSSLF
Mflv_0405|M.gilvum_PYR-GCK          LDDALLSQQSVERFRTALAPKAFGAVHLDRLTRVDDLDFFLVSSSVSSLF
MSMEG_0408|M.smegmatis_MC2_155      LDDALLSAQNPERFRTTLAPKAYGASHLDRLTRDDDLDFFIVSSSVSSLF
Mb2971c|M.bovis_AF2122/97           LDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFVLCSSIAATV
MLBr_00135|M.leprae_Br4923          LDDGAITSLTPDRVDTVLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATV
MUL_2005|M.ulcerans_Agy99           LDDAVISSLTPERIDTVLRAKVDAAWNLHEATLDLDLSMFVLCSSIAATV
MMAR_0101|M.marinum_M               LDDTVIASLTPDRMNPVLRAKVDGAWHLHQLTRGLGLSMFVLCSSIAGVM
Rv2048c|M.tuberculosis_H37Rv        LDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLV
MAV_2450|M.avium_104                LDDAVVTSLTPQRIDTVLRAKVDAAWNLHELTRDLDVGAFVMFSSIAGLA
TH_2454|M.thermoresistible__bu      EAGALLTNTTAEDIEATMRPKVDGVLALHEVFPPGRLDWLVLFSSCGYLG
                                      .  :   . : .  .: .*. ..  *..      :  ::: ** .   

MAB_0939|M.abscessus_ATCC_1997      GSPGQSNYATANALLDGLIAQRRAQGLPATGINFGPWGQGGMASSEAAT-
Mvan_0269|M.vanbaalenii_PYR-1       GSPGQANYATANALLDGLTAHRRARGLPATGVNFGPWAQGGMASSEAAT-
Mflv_0405|M.gilvum_PYR-GCK          GSPGQSNYATANAFLDGLVAQRRAQGLPATGVNFGPWARGGMASSEAAA-
MSMEG_0408|M.smegmatis_MC2_155      GSPGQANYATANAMLDGLVAKRRAQGLVATGINFGPWGQGGMASSEAAT-
Mb2971c|M.bovis_AF2122/97           GSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSR
MLBr_00135|M.leprae_Br4923          GSPGQGNYSAANAFLDGLAAYRQAAGLAGTSLAWGLWEQPGGMNAHLSSR
MUL_2005|M.ulcerans_Agy99           GSPGQGNYSAANSFLDGLAAHRQAAGLAGISVAWGLWEQSGGMAAHLSSR
MMAR_0101|M.marinum_M               GSPGQGNYAAANTFLDALAAHRRATGLAGLSVQWGLWEQTSAMTGHLGER
Rv2048c|M.tuberculosis_H37Rv        GSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATV
MAV_2450|M.avium_104                GASGQGNYAAGNSFLDGLAAHRRAHGLPAISLGWGLWDQASAMTGGLGAA
TH_2454|M.thermoresistible__bu      GFPGQGAYACGNAYLDAFARYRRASGDATTSVAWTAWRGLG--MGSASDF
                                    * .**. *: .*: **.:   *:* *    .: :  *   .   .  .  

MAB_0939|M.abscessus_ATCC_1997      --ANISAQGLIPLDPSAALAALAEVVANGTGQATILKANWQRAAKVLGSS
Mvan_0269|M.vanbaalenii_PYR-1       --ANIGAQGLVPLEPSAALGALAEVLANGTGQAAVLKANWQRAAKVLGSS
Mflv_0405|M.gilvum_PYR-GCK          --ANISAQGLIPLEPSAALTAMAEVVANGTAQATVLKANWQRAAKVLGSS
MSMEG_0408|M.smegmatis_MC2_155      --ANITAQGLIPLDPSAALHALAEVIANGSGQATVLKANWQRAAKVLGSA
Mb2971c|M.bovis_AF2122/97           DLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAG
MLBr_00135|M.leprae_Br4923          DLARISRSGLAPMNPAQALELFDAALVIDHPFMVTALLDRAALDAQAQAG
MUL_2005|M.ulcerans_Agy99           DLARMSRSGLAPMNPEQAVGLLDAVLAINHPLMVATLLDRPALEARAQAG
MMAR_0101|M.marinum_M               DLARIRRSGLAPMSVGQAVELFDAAVLLDRSTVVAACLDRNALASPAVSA
Rv2048c|M.tuberculosis_H37Rv        DFKRFARDGIVAMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGG
MAV_2450|M.avium_104                DLARFGRDGIVAMSSQEALELMDTALIVDEPFLLPAHIDLAALRVKFDGG
TH_2454|M.thermoresistible__bu      VAAQLDALGMGTVDVDDAMRALDAAIRDGDPNVVVLPLSPAAAAVPMFAD
                                       .:   *: .:.   *:  :  .:  .         .         . 

MAB_0939|M.abscessus_ATCC_1997      RPP---------ILDLVLPSAVGEVTGDSELLKQLMEIPVPQRAGFVTEF
Mvan_0269|M.vanbaalenii_PYR-1       RPP---------ILDLVLPRPEGEVAGDSELLRQLQEIPVAQRAGFVTEF
Mflv_0405|M.gilvum_PYR-GCK          RPP---------ILDLVLPSAVGEITGDSELLKQLQEIPVPQRAGFVTEF
MSMEG_0408|M.smegmatis_MC2_155      RPP---------ILDLVLPSAAGEATGDSELLKQLMEIPIPQRAGFVTEF
Mb2971c|M.bovis_AF2122/97           ALPALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGL
MLBr_00135|M.leprae_Br4923          ALPPLFSRLVRRSRRRQIEDPGDATQSKLALVQRLQGLAANRQLELLVGV
MUL_2005|M.ulcerans_Agy99           GLPPLFAGVVRRPRRRQIEDTGDAAQSKSALAERLNGLSAGERQDALVGL
MMAR_0101|M.marinum_M               ELPMLFHSLLPRPSRRVIN--KDATTHESGLAQRLQALSPHQQHQLLVET
Rv2048c|M.tuberculosis_H37Rv        TLPPMFVDLINAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQHAVLLDL
MAV_2450|M.avium_104                TLPPMFVDLINAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQQAVLLDL
TH_2454|M.thermoresistible__bu      VAP----------ADPDADAPGGEVPDGLSDGFPADGFPDDGDLAEWVHR
                                      *                                  :.           

MAB_0939|M.abscessus_ATCC_1997      LQREVQNFLRLAQPPAATSR--FLDLGTDSLMAIELRNRLHSQFGGKFTI
Mvan_0269|M.vanbaalenii_PYR-1       LQREVQNFLRLAQPPAATSR--FLDLGTDSLMAIELRNRLHSQFGGAFTI
Mflv_0405|M.gilvum_PYR-GCK          LQKEVQNFLRLAQPPAATSR--FLDLGTDSLMAIELRNRLHSQFGGAFTI
MSMEG_0408|M.smegmatis_MC2_155      LQREVQNFLRLASPPAASSR--FLDLGTDSLMAIELRNRLHSQFGGKFTI
Mb2971c|M.bovis_AF2122/97           VCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATG--LTL
MLBr_00135|M.leprae_Br4923          VCLQAAAVLGRPSPEDIDPNTKFQDLGFDSLTAVELRNRLKSATG--LTL
MUL_2005|M.ulcerans_Agy99           VCLQAAAVLGRPSPEDIDPEAGFQDLGFDSLTAVELRNRFKSATG--LTL
MMAR_0101|M.marinum_M               VRNQAAVVLGRPSGQDIDPECTFQDLGLDSLTAVELRNRLKAASG--LSL
Rv2048c|M.tuberculosis_H37Rv        VRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEMRNRLKSATG--LAL
MAV_2450|M.avium_104                VRSNIATVLGSSSPEAIHPDRAFQELGFDSLTAVEMRNRLKAATG--LAL
TH_2454|M.thermoresistible__bu      RVIAAVAGELGLAETDVDPRLPLVEIGVDSIMTVALRRQLERQTG--LTL
                                                      .   : ::* **: :: :*.::.   *  :::

MAB_0939|M.abscessus_ATCC_1997      NATAVFDYPTIGGLAEYLVGQLPDADAESAEAPPAVESAEAESGAGPAAA
Mvan_0269|M.vanbaalenii_PYR-1       NATAVFDYPTIGGLAEYLVGQLPDSDAAAGETPATETSPIDHNHPDREAD
Mflv_0405|M.gilvum_PYR-GCK          NATAVFDYPTIGGLAEYLVAQLPD-----AETPQAAPQSESEPGPDVTE-
MSMEG_0408|M.smegmatis_MC2_155      NATAVFDYPTIGGLAEYLVGQLPD-----AEAPETA--------------
Mb2971c|M.bovis_AF2122/97           PPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA-
MLBr_00135|M.leprae_Br4923          PPTVIFDHPTPTAVAEYVAQQMLKSRPAESGDETSQAVEPKVEEVSVHA-
MUL_2005|M.ulcerans_Agy99           PPTVIFDHPTPTAIAEYVGRQIPDSQATQAEEE--KLPESDGEMVSVTA-
MMAR_0101|M.marinum_M               SPTLIFDYPTPATLARHLAQQLIGTGTTGSAQIESQLETLQQTLLAIEDG
Rv2048c|M.tuberculosis_H37Rv        SPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAELQRIVASIPVK
MAV_2450|M.avium_104                SPTLIFDYPNSAALAGYMYRELVGTSEQPTAAAAPGEAEIQRVVGSIPVK
TH_2454|M.thermoresistible__bu      PPTLLWEHPTAGAVSDRIVEMLRARG------------------------
                                     .* ::::*.   ::  :   :                            

MAB_0939|M.abscessus_ATCC_1997      SDAVSELKE-----------------------------------------
Mvan_0269|M.vanbaalenii_PYR-1       SPG-----------------------------------------------
Mflv_0405|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_0408|M.smegmatis_MC2_155      --------------------------------------------------
Mb2971c|M.bovis_AF2122/97           --------------------------------------------------
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
MUL_2005|M.ulcerans_Agy99           --------------------------------------------------
MMAR_0101|M.marinum_M               DKQRV-AAQLRKFLTRLLAPAESGRPLDDRIKDATSPSEILQLIDAGSIE
Rv2048c|M.tuberculosis_H37Rv        RLRQAGVLDLLLALANETETSGQDPALAPTAEQEIADMDLDDLVNAAFRN
MAV_2450|M.avium_104                RLRQAGVLELLLALANESTGTAQSATPAVTTEKDIADMDLDDLVNAALLD
TH_2454|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MAB_0939|M.abscessus_ATCC_1997      ----
Mvan_0269|M.vanbaalenii_PYR-1       ----
Mflv_0405|M.gilvum_PYR-GCK          ----
MSMEG_0408|M.smegmatis_MC2_155      ----
Mb2971c|M.bovis_AF2122/97           ----
MLBr_00135|M.leprae_Br4923          ----
MUL_2005|M.ulcerans_Agy99           ----
MMAR_0101|M.marinum_M               S---
Rv2048c|M.tuberculosis_H37Rv        DDE-
MAV_2450|M.avium_104                DDDE
TH_2454|M.thermoresistible__bu      ----