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GEISTKERLVTEAMRLFGEQGYKATSVAQIEKAAGLTPGSGGLYHHFKSKEALLEAGIDRQLDRRRAMRD IRALFGGLGDLRNELTMMGRYVLAVLDEESQLLQIASSVPSGRPARLDHAYAALFDGLYGELSDWVQGWA PDISKQDAESIGVLGVNALLGKRATSAVFRGAARDIADEDYVVEWTALLAMRIESLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3313c | - | - | 100% (198) | TetR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0835c | - | 1e-08 | 45.95% (74) | TetR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4046c | - | 4e-08 | 27.67% (159) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 5e-08 | 33.10% (142) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_2447 | - | 5e-09 | 46.25% (80) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 5e-08 | 33.10% (142) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_1444 | - | 2e-74 | 70.20% (198) | TetR family transcriptional regulator |
| M. avium 104 | MAV_0146 | - | 6e-15 | 29.73% (185) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0532 | - | 2e-14 | 29.44% (197) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0256 | - | 7e-09 | 50.00% (54) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4947 | - | 2e-15 | 32.82% (131) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4204 | - | 3e-09 | 45.68% (81) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3313c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1444|M.marinum_M --------------------------------------------------
MAV_0146|M.avium_104 --------------------------------------------------
MUL_4947|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0532|M.smegmatis_MC2_155 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 MASVAQPVRRRPKDRKKQILDQAVGLFIERGFHSVKLEDIAEAAGVTARA
Rv1963c|M.tuberculosis_H37Rv MASVAQPVRRRPKDRKKQILDQAVGLFIERGFHSVKLEDIAEAAGVTARA
Mflv_2447|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4204|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0256|M.thermoresistible__bu --------------------------------------------------
MAB_3313c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1444|M.marinum_M --------------------------------------------------
MAV_0146|M.avium_104 --------------------------------------------------
MUL_4947|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0532|M.smegmatis_MC2_155 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 LYRHYDNKQALLAEAIRTGQDQYQSARRLTEGETEPTPRPLNADLEDLIA
Rv1963c|M.tuberculosis_H37Rv LYRHYDNKQALLAEAIRTGQDQYQSARRLTEGETEPTPRPLNADLEDLIA
Mflv_2447|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4204|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0256|M.thermoresistible__bu --------------------------------------------------
MAB_3313c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1444|M.marinum_M --------------------------------------------------
MAV_0146|M.avium_104 --------------------------------------------------
MUL_4947|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0532|M.smegmatis_MC2_155 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 AAVASRALTVLWQREARYLNEDDRTAVRRRINAIVAGMRDSVLLEVPDLS
Rv1963c|M.tuberculosis_H37Rv AAVASRALTVLWQREARYLNEDDRTAVRRRINAIVAGMRDSVLLEVPDLS
Mflv_2447|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4204|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0256|M.thermoresistible__bu --------------------------------------------------
MAB_3313c|M.abscessus_ATCC_199 ------------------------------------MGEISTKE------
MMAR_1444|M.marinum_M ------------------------------------MRAASTRE------
MAV_0146|M.avium_104 -------------------------------------MLSSGRD------
MUL_4947|M.ulcerans_Agy99 -------------------------------------MSTSGRD------
MSMEG_0532|M.smegmatis_MC2_155 --------------------------------------MSAARD------
Mb1998c|M.bovis_AF2122/97 PQHSELRAWAVSSTLTSLGRHSLSLPGEELKKLLYQACMAAARTPPVCEL
Rv1963c|M.tuberculosis_H37Rv PQHSELRAWAVSSTLTSLGRHSLSLPGEELKKLLYQACMAAARTPPVCEL
Mflv_2447|M.gilvum_PYR-GCK -----------------MSAPESVGSDLETSRRPYAALFAKGED------
Mvan_4204|M.vanbaalenii_PYR-1 -----------------MSAPESAASDLGNAKRPYATLFAKGED------
TH_0256|M.thermoresistible__bu ----------------------------VTQTRPYETLLAKGED------
.
MAB_3313c|M.abscessus_ATCC_199 ---------------------RLVTEAMRLFGEQGYKATSVAQIEKAAGL
MMAR_1444|M.marinum_M ---------------------RLVTEAMRLFGERGYHATSVAQIEAAAGL
MAV_0146|M.avium_104 ---------------------RLLSAALRLFAAKGYAATSVADIQRESGL
MUL_4947|M.ulcerans_Agy99 ---------------------RLLSAALKLFAVKGYAATSVADIQRCSGL
MSMEG_0532|M.smegmatis_MC2_155 ---------------------RLMAAALKLFAAKGYAATSVAEIQQQAGL
Mb1998c|M.bovis_AF2122/97 PPLPAGDAARDEADVLFSRYETLLAAGARLFRAQGYPAVNTSEIGKGAGI
Rv1963c|M.tuberculosis_H37Rv PPLPAGDAARDEADVLFSRYETLLAAGARLFRAQGYPAVNTSEIGKGAGI
Mflv_2447|M.gilvum_PYR-GCK ------------------RRQRILAVAERLLARNGWRNTSLAQIAREAGV
Mvan_4204|M.vanbaalenii_PYR-1 ------------------RRQRILAVAERLLARNGWRSTSLAQIAREAGV
TH_0256|M.thermoresistible__bu ------------------RRQRILAVAERLLARNGWRNTSLAQIAKEAGV
::: . :*: .*: .. ::* :*:
MAB_3313c|M.abscessus_ATCC_199 TPGSGGLYHHFKSKEALLEAGIDRQLDRRRAMRDIRALFGGLGDLRNELT
MMAR_1444|M.marinum_M ASGSGALYHHFDSKESLLEAGIDRQLDRRRAMGDLRALFAGLGDPRSELT
MAV_0146|M.avium_104 APGSGALYKHFGSKRELLEAAVAHRIESIVTAREQYDAGQ-PGSVEQAVR
MUL_4947|M.ulcerans_Agy99 APGSGALYKHFGSKHELLEAAVEHRIDSIVAAREQYDAGE-PGGVEQAVR
MSMEG_0532|M.smegmatis_MC2_155 APGSGALYKHFGSKRELLEAAITHRIDNIVAAREQYDAEK-PRTVEDAVR
Mb1998c|M.bovis_AF2122/97 AG--PGLYRSFSSKQAILDALIR-RLDEWRCLECIRALRA-NQQAAQRLR
Rv1963c|M.tuberculosis_H37Rv AG--PGLYRSFSSKQAILDALIR-RLDEWRCLECIRALRA-NQQAAQRLR
Mflv_2447|M.gilvum_PYR-GCK TP--AGLLHHFESKEQLLNAVL----DARDADDDAHADRG-GDLVTELAR
Mvan_4204|M.vanbaalenii_PYR-1 TP--AGLLHHFESKEQLLNAVL----DARDADDDAHADRS-GDLIAELTR
TH_0256|M.thermoresistible__bu SP--AGLLHHFESKEALLNAVL----DARDADDDAHADRS-GDLIAEIAR
: .* : * **. :*:* : : .
MAB_3313c|M.abscessus_ATCC_199 MMGRYVLAVLDEESQLLQIASSVPSGRPARLDHAYAALFDGLYGELSDWV
MMAR_1444|M.marinum_M LLGRYVLAVLDEESQLLQIAAALPTGRPAQLDDAYAALFAGLNAELTDWV
MAV_0146|M.avium_104 TAGQLIWNNLKQSEDLLKVMLREPDELGDLDEKTWQVITDNAYQRFADEL
MUL_4947|M.ulcerans_Agy99 TAGHLIWTNLKQSEDLLKVMLREPGALGDLDEKTWQIITDNAYQRFADEL
MSMEG_0532|M.smegmatis_MC2_155 SAGQLIWTNLTQSEELLRVMLREPDELGDLDEKTWQVITDNAYQRFADEL
Mb1998c|M.bovis_AF2122/97 GLVQGHVRISLDAPDLVAVSVTELSHASVEVRDGYLRNQGDREAVWIDLI
Rv1963c|M.tuberculosis_H37Rv GLVQGHVRISLDAPDLVAVSVTELSHASVEVRDGYLRNQGDREAVWIDLI
Mflv_2447|M.gilvum_PYR-GCK --VPERFERSPELVGTFMVLLAENIAPDAPLHDRLHKRYRDAVDIIEDII
Mvan_4204|M.vanbaalenii_PYR-1 --VPKRFERSPELVGTFMVLLAENLAPDAPLHDRLHQRYRAAADIIKDLI
TH_0256|M.thermoresistible__bu --VAERFDRAPHLVGTFTVLLVENIQPEAPLHDRMLARQRAAIDIVADLI
. . : . * :
MAB_3313c|M.abscessus_ATCC_199 QG--WAPDISKQDAESIGVLGVNALLGKRATSAVFRGAARDIADEDYVVE
MMAR_1444|M.marinum_M KE--LVPTISKQQALTIGTVAVNSLFGNRATSTVFRTPVADLTDEQYIAE
MAV_0146|M.avium_104 AASNRAGRTSIPDPEAAAAVAIGSLSYAATLQALTGRLPGNTDEDRYFEA
MUL_4947|M.ulcerans_Agy99 AASNRSGRTRIPDPEAAASVAIASLSYALTLQALTGRSPGNIDDSRYFEA
MSMEG_0532|M.smegmatis_MC2_155 AASNRAGRTEIPDPEATAAVAIASLSYVATLHALNGRTPGNVDHDRFFEA
Mb1998c|M.bovis_AF2122/97 GKLVP---ATSVAQGRLLVAAAISFIEDVARTWHLTRYAGVADEISGLAL
Rv1963c|M.tuberculosis_H37Rv GKLVP---ATSVAQGRLLVAAAISFIEDVARTWHLTRYAGVADEISGLAL
Mflv_2447|M.gilvum_PYR-GCK TRGQRKGLYRTDFDAASKATEILAFINGMETLWLLDPSIPLTEVFKGYAE
Mvan_4204|M.vanbaalenii_PYR-1 TRGQQKGLYRKDFDAATKATEILAFINGMEIQWLLDPSIPLTEVYQGYAE
TH_0256|M.thermoresistible__bu RRGQESGRYRSDFDAATKAVEIIAFVNGMETSWLLDPSIPVAEVFKGYAE
::
MAB_3313c|M.abscessus_ATCC_199 WTALLAMRIESLR-----------------
MMAR_1444|M.marinum_M WATMLVNRIELLRKL---------------
MAV_0146|M.avium_104 WVNQTVSVLAQYTNRRKPLNDNDNDSGAQT
MUL_4947|M.ulcerans_Agy99 WVNQTVSMLSQYTN-PAPSRKPQADNKFQE
MSMEG_0532|M.smegmatis_MC2_155 WVAQTVAAIEQHRT------DNQTDNR---
Mb1998c|M.bovis_AF2122/97 AILTSGAGNLLRA-----------------
Rv1963c|M.tuberculosis_H37Rv AILTSGAGNLLRA-----------------
Mflv_2447|M.gilvum_PYR-GCK SLGRDLAL----------------------
Mvan_4204|M.vanbaalenii_PYR-1 SLARDLAAQPSPT-----------------
TH_0256|M.thermoresistible__bu MLERDFAP-PNPT-----------------