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MRAASTRERLVTEAMRLFGERGYHATSVAQIEAAAGLASGSGALYHHFDSKESLLEAGIDRQLDRRRAMG DLRALFAGLGDPRSELTLLGRYVLAVLDEESQLLQIAAALPTGRPAQLDDAYAALFAGLNAELTDWVKEL VPTISKQQALTIGTVAVNSLFGNRATSTVFRTPVADLTDEQYIAEWATMLVNRIELLRKL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1444 | - | - | 100% (200) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0150 | - | 6e-14 | 53.23% (62) | TetR family transcriptional regulator |
| M. marinum M | MMAR_5559 | - | 5e-09 | 33.33% (150) | putative regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 6e-08 | 29.55% (176) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_4599 | - | 3e-09 | 35.00% (100) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 6e-08 | 29.55% (176) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3313c | - | 2e-74 | 70.20% (198) | TetR family transcriptional regulator |
| M. avium 104 | MAV_0146 | - | 3e-13 | 54.10% (61) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0532 | - | 7e-14 | 55.74% (61) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2070 | - | 4e-07 | 43.28% (67) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY |
| M. ulcerans Agy99 | MUL_4947 | - | 6e-14 | 53.23% (62) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3994 | - | 4e-08 | 30.53% (190) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1998c|M.bovis_AF2122/97 -MASVAQPVRRRPKDRKKQILDQAVGLFIERGFHSVKLEDIAEAAGVTAR
Rv1963c|M.tuberculosis_H37Rv -MASVAQPVRRRPKDRKKQILDQAVGLFIERGFHSVKLEDIAEAAGVTAR
Mvan_3994|M.vanbaalenii_PYR-1 -------MVRRRPKDRKQQILDQAVRLFIDRGFHSVKLEDIAEASGVTAR
MMAR_1444|M.marinum_M ----------MRAASTRERLVTEAMRLFGERGYHATSVAQIEAAAGLASG
MAB_3313c|M.abscessus_ATCC_199 ----------MGEISTKERLVTEAMRLFGEQGYKATSVAQIEKAAGLTPG
MAV_0146|M.avium_104 -----------MLSSGRDRLLSAALRLFAAKGYAATSVADIQRESGLAPG
MUL_4947|M.ulcerans_Agy99 -----------MSTSGRDRLLSAALKLFAVKGYAATSVADIQRCSGLAPG
MSMEG_0532|M.smegmatis_MC2_155 ------------MSAARDRLMAAALKLFAAKGYAATSVAEIQQQAGLAPG
Mflv_4599|M.gilvum_PYR-GCK MNKVVVAGRTRVGGERRERILASATELIAERGYHAVSMADIGVASGVVGP
TH_2070|M.thermoresistible__bu -------MTNSGPPTRRDELLELAAQMFAERGLKATTVRDIADSAGILSG
:..:: * :: :* :..: :* :*:
Mb1998c|M.bovis_AF2122/97 --ALYRHYDNKQALLAEAIRTGQDQYQSARRLTEGETEPTPRPLNADLED
Rv1963c|M.tuberculosis_H37Rv --ALYRHYDNKQALLAEAIRTGQDQYQSARRLTEGETEPTPRPLNADLED
Mvan_3994|M.vanbaalenii_PYR-1 --ALYRHYDNKQALLAAAIRAGQEQYQSARPPAGGEAESPHRALSAELPD
MMAR_1444|M.marinum_M SGALYHHFDSKESLLEAGIDRQLDRRRAMG--------------------
MAB_3313c|M.abscessus_ATCC_199 SGGLYHHFKSKEALLEAGIDRQLDRRRAMR--------------------
MAV_0146|M.avium_104 SGALYKHFGSKRELLEAAVAHRIESIVTAR--------------------
MUL_4947|M.ulcerans_Agy99 SGALYKHFGSKHELLEAAVEHRIDSIVAAR--------------------
MSMEG_0532|M.smegmatis_MC2_155 SGALYKHFGSKRELLEAAITHRIDNIVAAR--------------------
Mflv_4599|M.gilvum_PYR-GCK --AIYRHFNSKSDLLAALFERVVDKLLKRA--------------------
TH_2070|M.thermoresistible__bu --SLYHHFASKEEMVDEVLRGFLDWLFDRY--------------------
.:*:*: .* :: . :
Mb1998c|M.bovis_AF2122/97 LIAAAVASRALTVLWQREARYLNEDDRTAVRRRINAIVAGMRDSVLLEVP
Rv1963c|M.tuberculosis_H37Rv LIAAAVASRALTVLWQREARYLNEDDRTAVRRRINAIVAGMRDSVLLEVP
Mvan_3994|M.vanbaalenii_PYR-1 LVTAAVASRSLTVLWQREARYLDAAERAEVRRRIHAIVTGIEQSLRVEVP
MMAR_1444|M.marinum_M --------------------------------------------------
MAB_3313c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_0146|M.avium_104 --------------------------------------------------
MUL_4947|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0532|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4599|M.gilvum_PYR-GCK --------------------------------------------------
TH_2070|M.thermoresistible__bu --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 DLSPQHSELRAWAVSSTLTSLGRHSLSLPGEELKKLLYQACMAAARTPPV
Rv1963c|M.tuberculosis_H37Rv DLSPQHSELRAWAVSSTLTSLGRHSLSLPGEELKKLLYQACMAAARTPPV
Mvan_3994|M.vanbaalenii_PYR-1 DLSPRHAELRAWAVSSVITSLGRHSLTLAKDELHRLLFGACMAVARTPPV
MMAR_1444|M.marinum_M --DLRALFAGLGDPRSELTLLGRYVLAVLDEESQLLQIAAALPTGRP---
MAB_3313c|M.abscessus_ATCC_199 --DIRALFGGLGDLRNELTMMGRYVLAVLDEESQLLQIASSVPSGRP---
MAV_0146|M.avium_104 --EQYDAGQ-PGSVEQAVRTAGQLIWNNLKQSEDLLKVMLREPDELG---
MUL_4947|M.ulcerans_Agy99 --EQYDAGE-PGGVEQAVRTAGHLIWTNLKQSEDLLKVMLREPGALG---
MSMEG_0532|M.smegmatis_MC2_155 --EQYDAEK-PRTVEDAVRSAGQLIWTNLTQSEELLRVMLREPDELG---
Mflv_4599|M.gilvum_PYR-GCK ----TAIVEQSRDEAEALTLLVSDQVALVMDQRELAMVYYREVHNLS---
TH_2070|M.thermoresistible__bu ----RSIVETEPNPLERFKGLFMASFEAIEHRHAQVVIYQDEAKRLS---
. . .
Mb1998c|M.bovis_AF2122/97 CELPPLPAGDAARDEADVLFSRYETLLAAGARLFRAQGYPAVNTSEIGKG
Rv1963c|M.tuberculosis_H37Rv CELPPLPAGDAARDEADVLFSRYETLLAAGARLFRAQGYPAVNTSEIGKG
Mvan_3994|M.vanbaalenii_PYR-1 G---PLEPDVAPPNDERALFSRHETLLAAGARLFRAQGYPAVSTSEIGKG
MMAR_1444|M.marinum_M ---------AQLDDAYAALFAGLNAELTDWVKE--LVPTISKQQALTIGT
MAB_3313c|M.abscessus_ATCC_199 ---------ARLDHAYAALFDGLYGELSDWVQG--WAPDISKQDAESIGV
MAV_0146|M.avium_104 ---------DLDEKTWQVITDNAYQRFADELAASNRAGRTSIPDPEAAAA
MUL_4947|M.ulcerans_Agy99 ---------DLDEKTWQIITDNAYQRFADELAASNRSGRTRIPDPEAAAS
MSMEG_0532|M.smegmatis_MC2_155 ---------DLDEKTWQVITDNAYQRFADELAASNRAGRTEIPDPEATAA
Mflv_4599|M.gilvum_PYR-GCK ---------DQHQSRLRRKQRLYLEEWVHLVGELRPAVDEIELRAMVHGA
TH_2070|M.thermoresistible__bu -----------SQPRFAYVEQRNREQRKMWVDVLTQGIEEGYFRSDIDVD
.
Mb1998c|M.bovis_AF2122/97 AGIAGPGLYRSFSSKQAILDALIRRLDEWRCLECIRALRANQQAAQRLRG
Rv1963c|M.tuberculosis_H37Rv AGIAGPGLYRSFSSKQAILDALIRRLDEWRCLECIRALRANQQAAQRLRG
Mvan_3994|M.vanbaalenii_PYR-1 VGIAGPGLYRSFSSKQAILDALITRLDEWWSLACIRVLRTDTEAAECLRA
MMAR_1444|M.marinum_M VAVNSLFGNRATST------------------------------------
MAB_3313c|M.abscessus_ATCC_199 LGVNALLGKRATSA------------------------------------
MAV_0146|M.avium_104 VAIGSLSYAATLQA------------------------------------
MUL_4947|M.ulcerans_Agy99 VAIASLSYALTLQA------------------------------------
MSMEG_0532|M.smegmatis_MC2_155 VAIASLSYVATLHA------------------------------------
Mflv_4599|M.gilvum_PYR-GCK IGAIQSILHYRGTG------------------------------------
TH_2070|M.thermoresistible__bu LVYRFIRDTTWVSVR-----------------------------------
Mb1998c|M.bovis_AF2122/97 LVQGHVRISLDAPDLVAVSVTELSHASVEVRDGYLRNQGDREAVWIDLIG
Rv1963c|M.tuberculosis_H37Rv LVQGHVRISLDAPDLVAVSVTELSHASVEVRDGYLRNQGDREAVWIDLIG
Mvan_3994|M.vanbaalenii_PYR-1 LVAGRVQISLDDPDLVAMSVTELSFASEEVRDRYMRNQADREAVWIELIG
MMAR_1444|M.marinum_M -VFRTPVADLTDEQYIAEWATMLVNRIELLRKL-----------------
MAB_3313c|M.abscessus_ATCC_199 -VFRGAARDIADEDYVVEWTALLAMRIESLR-------------------
MAV_0146|M.avium_104 -LTGRLPGNTDEDRYFEAWVNQTVSVLAQYTNRRKPLNDNDNDSGAQT--
MUL_4947|M.ulcerans_Agy99 -LTGRSPGNIDDSRYFEAWVNQTVSMLSQYTN-PAPSRKPQADNKFQE--
MSMEG_0532|M.smegmatis_MC2_155 -LNGRTPGNVDHDRFFEAWVAQTVAAIEQHRT------DNQTDNR-----
Mflv_4599|M.gilvum_PYR-GCK LAPEQTSALLVAMGHAVLGVPASSHQVRGVNTEPSCPRPGTPQH------
TH_2070|M.thermoresistible__bu --WYRPGGPLTAEEVGRQYLSIVLGGITAGAN------------------
Mb1998c|M.bovis_AF2122/97 KLVPATSVAQGRLLVAAAISFIEDVARTWHLTRYAGVADEISGLALAILT
Rv1963c|M.tuberculosis_H37Rv KLVPATSVAQGRLLVAAAISFIEDVARTWHLTRYAGVADEISGLALAILT
Mvan_3994|M.vanbaalenii_PYR-1 KLVPQTAPAEARLLVGAANSFIDDAVRTWHLTRYAGIADEITAITLSILT
MMAR_1444|M.marinum_M --------------------------------------------------
MAB_3313c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_0146|M.avium_104 --------------------------------------------------
MUL_4947|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0532|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4599|M.gilvum_PYR-GCK --------------------------------------------------
TH_2070|M.thermoresistible__bu --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 SGAGNLLRA
Rv1963c|M.tuberculosis_H37Rv SGAGNLLRA
Mvan_3994|M.vanbaalenii_PYR-1 SRQ------
MMAR_1444|M.marinum_M ---------
MAB_3313c|M.abscessus_ATCC_199 ---------
MAV_0146|M.avium_104 ---------
MUL_4947|M.ulcerans_Agy99 ---------
MSMEG_0532|M.smegmatis_MC2_155 ---------
Mflv_4599|M.gilvum_PYR-GCK ---------
TH_2070|M.thermoresistible__bu ---------