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MELRQLEHFVAVAGEMSFSRAVQRAHVVQSALSTSVGKLEKELGVELFDRTRQQIRLTPAGELFHTHATR VIQAARYAKDSIGNFRGELTGTVDLGALITFGPLDVPKMLGQFHREYPLVQIRLRQSQSGSNAYLSAIAD GTLDLALVSAPDRFPAGIQMRLLCQEPMMFVCRPDHRLAQRRHVTVTELVDEHLIGFPPQFSLRRIVEDA FTAAGVTAFTPHEVALEYAIAASLVHHGLGTIFMPASEAAQFPHLRALAVRPAIIWKIYLASAEQSQLGP ASAQLAEHLVASAHAQTNSPKT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3308 | - | - | 100% (302) | LysR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2238 | - | 3e-34 | 30.31% (287) | LysR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3208c | - | 3e-27 | 31.41% (277) | LysR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 6e-14 | 34.35% (131) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_3565 | - | 4e-36 | 34.01% (294) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 6e-14 | 34.35% (131) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02041 | oxyR | 1e-18 | 29.51% (244) | putative LysR-family transcriptional regulator |
| M. marinum M | MMAR_2756 | oxyR | 6e-20 | 28.57% (245) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_1538 | - | 1e-22 | 28.68% (265) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_6849 | - | 6e-96 | 59.39% (293) | LysR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_3504 | - | 8e-14 | 30.05% (203) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 1e-19 | 28.57% (245) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_0328 | - | 4e-92 | 56.31% (293) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6849|M.smegmatis_MC2_155 ---------------MELRQLEHFVAVAEELSFTRAAQRVHVVQSALSSS
Mvan_0328|M.vanbaalenii_PYR-1 ---------------MELRQVEHFLAVAGEMSFTRAAERVHVVQSALSTS
MAB_3308|M.abscessus_ATCC_1997 ---------------MELRQLEHFVAVAGEMSFSRAVQRAHVVQSALSTS
Mflv_3565|M.gilvum_PYR-GCK ---------------MELRQLEYFVAIVEEGGFTRAASRERVAQPAVSAQ
MMAR_2756|M.marinum_M MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MUL_2998|M.ulcerans_Agy99 -----MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MLBr_02041|M.leprae_Br4923 --------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQA
Mb0121|M.bovis_AF2122/97 ---------------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSA
Rv0117|M.tuberculosis_H37Rv ---------------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSA
MAV_1538|M.avium_104 ---------------MAVGDYEWFITLAELQHVTAAAEQLHVAQPTLTRM
TH_3504|M.thermoresistible__bu ----------VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSA
. *:::. . *. : * :::
MSMEG_6849|M.smegmatis_MC2_155 VAKLERELGVELLDRTRQQISLTAAGDRFRTYALGVLREARNAVDVVSEF
Mvan_0328|M.vanbaalenii_PYR-1 IAKLERELDVDLFDRSRQQIRLTAAGDRFLTHAYEVLRVSRAAADSVGEF
MAB_3308|M.abscessus_ATCC_1997 VGKLEKELGVELFDRTRQQIRLTPAGELFHTHATRVIQAARYAKDSIGNF
Mflv_3565|M.gilvum_PYR-GCK IRRLERSVGQPLLTRTSREVRLTRAGEALLPHARAALAAVRDGRAAVDDV
MMAR_2756|M.marinum_M LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MUL_2998|M.ulcerans_Agy99 LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MLBr_02041|M.leprae_Br4923 LAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGE
Mb0121|M.bovis_AF2122/97 IAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAV
Rv0117|M.tuberculosis_H37Rv IAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAV
MAV_1538|M.avium_104 LARLEQRLGVALFDRHGRRLSLNTYGRIFYEHARRAQLELDSARRAIADL
TH_3504|M.thermoresistible__bu VRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQT
: ** :. *. * :. * : .
MSMEG_6849|M.smegmatis_MC2_155 RGELSGTVDFGSLISFGPMDVARALGDFHRAHPHVRLRLRLSQSGASAYL
Mvan_0328|M.vanbaalenii_PYR-1 RQSLMGTVEFGSLISFGPMDVGRALGDFHRAHPFVRLRLRLSQAGASAYL
MAB_3308|M.abscessus_ATCC_1997 RGELTGTVDLGALITFGPLDVPKMLGQFHREYPLVQIRLRQSQSGSNAYL
Mflv_3565|M.gilvum_PYR-GCK AGLLRGSVAIG-TVTLHPMNVAHLIAEFHADHPDVEITLG--TATSDVLI
MMAR_2756|M.marinum_M ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVIEDQTER--LL
MUL_2998|M.ulcerans_Agy99 ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVIEDQTER--LL
MLBr_02041|M.leprae_Br4923 SDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLPTLTLRVVEDQTEH--LL
Mb0121|M.bovis_AF2122/97 RSGITGTLRLGTVPTAS-TTASLVLSAFCSAHPLAKVQVCSRLAAT-ELY
Rv0117|M.tuberculosis_H37Rv RSGITGTLRLGTVPTAS-TTASLVLSAFCSAHPLAKVQVCSRLAAT-ELY
MAV_1538|M.avium_104 ADPAVGEIRLAYLSSFGSTVVPRLIARFKESSPRVTFTLEEGAAES--IA
TH_3504|M.thermoresistible__bu EAAAQAHYVIGHTPALSGAEAYALIEPAVTAYPSTSFTLRQLYPDA--LT
. :. : : * . : .
MSMEG_6849|M.smegmatis_MC2_155 SGLIEGSLDLALISVP-NRFPPQLEMRLLFEEPMVFVCRPDHPVARRRRV
Mvan_0328|M.vanbaalenii_PYR-1 GALVEGSLDLALVSVP-DRFPRQLEMRLLFAEPMVFVCRGDHAFADRGTL
MAB_3308|M.abscessus_ATCC_1997 SAIADGTLDLALVSAP-DRFPAGIQMRLLCQEPMMFVCRPDHRLAQRRHV
Mflv_3565|M.gilvum_PYR-GCK AELGDGRLDLAIVSIAVDEDLPGLEVAVITDEAVEAAVADGHPLAHRRSL
MMAR_2756|M.marinum_M TALREGSLDTALIALP--ADYGGLTEIPIYEEDFVLALPPGHPMADRHGV
MUL_2998|M.ulcerans_Agy99 TALREGSLDTALIALP--ADYGGLTEIPIYEEDFVLALPPGHPMADRHGV
MLBr_02041|M.leprae_Br4923 TALREGALDAAMIALP--VETAGIAEIPIYDEDFVLALPPGHPLSGKRRV
Mb0121|M.bovis_AF2122/97 RRLREFELDAVIVHPE-TQDSDDVDLVPLYEEQYVLLSPADMLPPGTSTL
Rv0117|M.tuberculosis_H37Rv RRLREFELDAVIVHPE-TQDSDDVDLVPLYEEQYVLLSPADMLPPGTSTL
MAV_1538|M.avium_104 DRVRSGGVDIGVVSPR--PVERTLAWRSLFRQRLGVAVPDGHRFARGAAV
TH_3504|M.thermoresistible__bu DAVFDGTVQLGLRRGV--VPTPELATAVIGYHRVRVAFVDSHPLAARESV
: . :: : : : . . . :
MSMEG_6849|M.smegmatis_MC2_155 SLDVLGTEDLVGFPPE--FGLRRLTDDAFRAAGVQARTQYEVPAGFAAVA
Mvan_0328|M.vanbaalenii_PYR-1 DLADVALEDIVGFPPE--FGLRRLMEGAFRAVGVAPRTQYEVPAGFAAIA
MAB_3308|M.abscessus_ATCC_1997 TVTELVDEHLIGFPPQ--FSLRRIVEDAFTAAGVTAFTPHEVALEYAIAA
Mflv_3565|M.gilvum_PYR-GCK SLEQLSRHPLISLPAG--TGLRTRLDTACAAAGLRPRIAFEATS-PAELA
MMAR_2756|M.marinum_M PVAALSELPLLLLDEG--HCLRDQALDVCQNAGVRAELADTRAASLATAV
MUL_2998|M.ulcerans_Agy99 PVAALSELPLLLLDEG--HCLRDQALDVCQNAGVRAEHADTRADSLATAV
MLBr_02041|M.leprae_Br4923 PTTALAQLPLLLLDEG--HCLRDQTLDICRKSGVQAELANTRAASLATAV
Mb0121|M.bovis_AF2122/97 VWRDAAQLPLALLTAD--MRDRQVIDAAFADHAVSAIPQVETDSVASLFA
Rv0117|M.tuberculosis_H37Rv VWRDAAQLPLALLTAD--MRDRQVIDAAFADHAVSAIPQVETDSVASLFA
MAV_1538|M.avium_104 SMVDLADEPFVTMHPG--FGMRRLLDELCAAAQFRPRVALQAPN-LTTAA
TH_3504|M.thermoresistible__bu DITELAREQVALWAPPGTSYYSDFLMGACRRAGFEPDYVVSRVQGAATVA
. . . : .
MSMEG_6849|M.smegmatis_MC2_155 DLVANGLGTALMP------ASEARRLGNLTAVTLETAVI----WQVYLAS
Mvan_0328|M.vanbaalenii_PYR-1 DLVRNGLGTAFMP------ASEARRFSDLRPVELADHVL----WQVYLAS
MAB_3308|M.abscessus_ATCC_1997 SLVHHGLGTIFMP------ASEAAQFPHLRALAVRPAII----WKIYLAS
Mflv_3565|M.gilvum_PYR-GCK ELARHGLGVAILP------QSMARGGSGLHALRLAPELR----GRLVWAW
MMAR_2756|M.marinum_M QCVNGGLGVTLIP------QSAVSVEAARSRVGLAHFAAPTPGRRIGLVY
MUL_2998|M.ulcerans_Agy99 QCVNGGLGVTLIP------QSAVSVEAARSRVGLTHFAAPTPGRRIGLVY
MLBr_02041|M.leprae_Br4923 QCVTGGLGVTLLP------QSAAPVESVRSKLGLAQFAAPCPGRRIGLAF
Mb0121|M.bovis_AF2122/97 QVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLK---AQIALAT
Rv0117|M.tuberculosis_H37Rv QVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLK---AQIALAT
MAV_1538|M.avium_104 SLVAAGLGISLVP------IDGSSYPSGVSVKPLADADAY---RDVGMIW
TH_3504|M.thermoresistible__bu APLTTG-GIAFVT-----AAAGPTMNGRVQVVDLTPPLLVP-----VQAL
. . . :
MSMEG_6849|M.smegmatis_MC2_155 PPADRMTPATARLADTLLDEAVRARARRYGTRPGIDHP
Mvan_0328|M.vanbaalenii_PYR-1 RPVDHLTPATARLADALLDAAADARAQ-----------
MAB_3308|M.abscessus_ATCC_1997 AEQSQLGPASAQLAEHLVASAHAQTNSPKT--------
Mflv_3565|M.gilvum_PYR-GCK R-ADGANPAARVLGERARAMAVSPGSGAPAVVPGA---
MMAR_2756|M.marinum_M RASSGRDEAYRQLAAIMGESISNEQQVRLVN-------
MUL_2998|M.ulcerans_Agy99 RASSGRDEAYRQLAAIMGESISNEQQVRLVN-------
MLBr_02041|M.leprae_Br4923 RSASGRSASYRQIAKIIGELISTEHHVRLVA-------
Mb0121|M.bovis_AF2122/97 NALGPGSPVARALITCAQALALNEFFDTQLRGITRRR-
Rv0117|M.tuberculosis_H37Rv NALGPGSPVARALITCAQALALNEFFDTQLRGITRRR-
MAV_1538|M.avium_104 DSGRPLPRSARDFIAGAAAVGHGGW-------------
TH_3504|M.thermoresistible__bu WQRHTLSAIRDRILEGLG--------------------
: