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ELRQLEHFVAVAEELSFTRAAQRVHVVQSALSSSVAKLERELGVELLDRTRQQISLTAAGDRFRTYALGV LREARNAVDVVSEFRGELSGTVDFGSLISFGPMDVARALGDFHRAHPHVRLRLRLSQSGASAYLSGLIEG SLDLALISVPNRFPPQLEMRLLFEEPMVFVCRPDHPVARRRRVSLDVLGTEDLVGFPPEFGLRRLTDDAF RAAGVQARTQYEVPAGFAAVADLVANGLGTALMPASEARRLGNLTAVTLETAVIWQVYLASPPADRMTPA TARLADTLLDEAVRARARRYGTRPGIDHP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6849 | - | - | 100% (310) | LysR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_3840 | - | 1e-46 | 40.35% (285) | LysR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0104 | - | 2e-26 | 31.16% (292) | transcriptional regulator, LysR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 5e-18 | 30.86% (243) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_3565 | - | 1e-40 | 35.69% (311) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 5e-18 | 30.86% (243) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02041 | oxyR | 2e-20 | 30.28% (251) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3308 | - | 4e-96 | 59.39% (293) | LysR family transcriptional regulator |
| M. marinum M | MMAR_4157 | - | 2e-22 | 28.77% (285) | LuxR family transcriptional regulator |
| M. avium 104 | MAV_1538 | - | 5e-24 | 31.02% (245) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 5e-15 | 27.24% (290) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_4020 | - | 2e-22 | 28.77% (285) | LuxR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0328 | - | 1e-119 | 73.58% (299) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6849|M.smegmatis_MC2_155 -------MELRQLEHFVAVAEELSFTRAAQRVHVVQSALSSSVAKLEREL
Mvan_0328|M.vanbaalenii_PYR-1 -------MELRQVEHFLAVAGEMSFTRAAERVHVVQSALSTSIAKLEREL
MAB_3308|M.abscessus_ATCC_1997 -------MELRQLEHFVAVAGEMSFSRAVQRAHVVQSALSTSVGKLEKEL
Mflv_3565|M.gilvum_PYR-GCK -------MELRQLEYFVAIVEEGGFTRAASRERVAQPAVSAQIRRLERSV
MMAR_4157|M.marinum_M -------MELYQLRYFQAVAECGTLRGASEQLLVSQSAVSRAITLLEAEI
MUL_4020|M.ulcerans_Agy99 -------MELYQLRYFQAVAECGTLRGASEQLLVSQSAVSRAITLLEAEI
Mb0121|M.bovis_AF2122/97 -------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLEREL
Rv0117|M.tuberculosis_H37Rv -------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLEREL
MAV_1538|M.avium_104 -------MAVGDYEWFITLAELQHVTAAAEQLHVAQPTLTRMLARLEQRL
MLBr_02041|M.leprae_Br4923 MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQALAALESGL
TH_3504|M.thermoresistible__bu --VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSAVRALENDV
. * ::. . * : * ::: : ** :
MSMEG_6849|M.smegmatis_MC2_155 GVELLDRTRQQISLTAAGDRFRTYALGVLREARNAVDVVSEFRGELSGTV
Mvan_0328|M.vanbaalenii_PYR-1 DVDLFDRSRQQIRLTAAGDRFLTHAYEVLRVSRAAADSVGEFRQSLMGTV
MAB_3308|M.abscessus_ATCC_1997 GVELFDRTRQQIRLTPAGELFHTHATRVIQAARYAKDSIGNFRGELTGTV
Mflv_3565|M.gilvum_PYR-GCK GQPLLTRTSREVRLTRAGEALLPHARAALAAVRDGRAAVDDVAGLLRGSV
MMAR_4157|M.marinum_M GVQLFTRRGRTNELNRYGQALLVGSRLAQRSVSSAIDNVRELAGVSGGTV
MUL_4020|M.ulcerans_Agy99 GVQLFTRRGRTNELNRYGQALLVGSRLAQRSVSSAIDNVRELAGVSGGTV
Mb0121|M.bovis_AF2122/97 NVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTL
Rv0117|M.tuberculosis_H37Rv NVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTL
MAV_1538|M.avium_104 GVALFDRHGRRLSLNTYGRIFYEHARRAQLELDSARRAIADLADPAVGEI
MLBr_02041|M.leprae_Br4923 GVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGESDPLRGGM
TH_3504|M.thermoresistible__bu GADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQTEAAAQAHY
. *: * :. * : . .
MSMEG_6849|M.smegmatis_MC2_155 DFGSLISFGPMDVARALGDFHRAHPHVRLRLRLSQSGASAYLSGLIEGSL
Mvan_0328|M.vanbaalenii_PYR-1 EFGSLISFGPMDVGRALGDFHRAHPFVRLRLRLSQAGASAYLGALVEGSL
MAB_3308|M.abscessus_ATCC_1997 DLGALITFGPLDVPKMLGQFHREYPLVQIRLRQSQSGSNAYLSAIADGTL
Mflv_3565|M.gilvum_PYR-GCK AIG-TVTLHPMNVAHLIAEFHADHPDVEITLG--TATSDVLIAELGDGRL
MMAR_4157|M.marinum_M ALGFLHSLGMQTVPHLIRLHHSRFPQARFELH--QRSGQGVLSDLVSGVT
MUL_4020|M.ulcerans_Agy99 ALGFLHSLGMQTVPHLIRLHHSRFPQARFELH--QRSGQGVLSDLVSGVT
Mb0121|M.bovis_AF2122/97 RLG-TVPTASTTASLVLSAFCSAHPLAKVQVCS-RLAATELYRRLREFEL
Rv0117|M.tuberculosis_H37Rv RLG-TVPTASTTASLVLSAFCSAHPLAKVQVCS-RLAATELYRRLREFEL
MAV_1538|M.avium_104 RLAYLSSFGSTVVPRLIARFKESSPRVTFTLE--EGAAESIADRVRSGGV
MLBr_02041|M.leprae_Br4923 RLGLIPTVAPYVLPTMLTGLTHRLP--TLTLRVVEDQTEHLLTALREGAL
TH_3504|M.thermoresistible__bu VIGHTPALSGAEAYALIEPAVTAYPSTSFTLR--QLYPDALTDAVFDGTV
:. . : * . : : .
MSMEG_6849|M.smegmatis_MC2_155 DLALISVP-NRFPPQLEMRLLFEEPMVFVCRPDHPVARRRRVSLDVLGTE
Mvan_0328|M.vanbaalenii_PYR-1 DLALVSVP-DRFPRQLEMRLLFAEPMVFVCRGDHAFADRGTLDLADVALE
MAB_3308|M.abscessus_ATCC_1997 DLALVSAP-DRFPAGIQMRLLCQEPMMFVCRPDHRLAQRRHVTVTELVDE
Mflv_3565|M.gilvum_PYR-GCK DLAIVSIAVDEDLPGLEVAVITDEAVEAAVADGHPLAHRRSLSLEQLSRH
MMAR_4157|M.marinum_M DVSLSFPAAFEGYGEIAWQTLFTQQLYAVVSTDHPLAGRRLIRFPELAAY
MUL_4020|M.ulcerans_Agy99 DVSLSFPAAFEGYGEIAWQTLFTQQLYAVVSTDHPLAGRRLIRFPELAAY
Mb0121|M.bovis_AF2122/97 DAVIVHPETQDSD-DVDLVPLYEEQYVLLSPADMLPPGTSTLVWRDAAQL
Rv0117|M.tuberculosis_H37Rv DAVIVHPETQDSD-DVDLVPLYEEQYVLLSPADMLPPGTSTLVWRDAAQL
MAV_1538|M.avium_104 DIGVVSPR--PVERTLAWRSLFRQRLGVAVPDGHRFARGAAVSMVDLADE
MLBr_02041|M.leprae_Br4923 DAAMIALP--VETAGIAEIPIYDEDFVLALPPGHPLSGKRRVPTTALAQL
TH_3504|M.thermoresistible__bu QLGLRRGV--VPTPELATAVIGYHRVRVAFVDSHPLAARESVDITELARE
: : : : . . . :
MSMEG_6849|M.smegmatis_MC2_155 DLVGFPPEFG--LRRLTDDAFRAAGVQARTQYEVPAGFAAVADLVANGLG
Mvan_0328|M.vanbaalenii_PYR-1 DIVGFPPEFG--LRRLMEGAFRAVGVAPRTQYEVPAGFAAIADLVRNGLG
MAB_3308|M.abscessus_ATCC_1997 HLIGFPPQFS--LRRIVEDAFTAAGVTAFTPHEVALEYAIAASLVHHGLG
Mflv_3565|M.gilvum_PYR-GCK PLISLPAGTG--LRTRLDTACAAAGLRPRIAFEATS-PAELAELARHGLG
MMAR_4157|M.marinum_M PFVVLDRDHT--LRRIVDAACARHGIDPTLAFEGTD-VGTLRGLIGANLG
MUL_4020|M.ulcerans_Agy99 PFVVLDRDHT--LRRIVDAACARHGIDPTPAFEGTD-VGTLRGLIGANLG
Mb0121|M.bovis_AF2122/97 PLALLTADMR--DRQVIDAAFADHAVSAIPQVETDSVASLFAQVATGNWA
Rv0117|M.tuberculosis_H37Rv PLALLTADMR--DRQVIDAAFADHAVSAIPQVETDSVASLFAQVATGNWA
MAV_1538|M.avium_104 PFVTMHPGFG--MRRLLDELCAAAQFRPRVALQAPN-LTTAASLVAAGLG
MLBr_02041|M.leprae_Br4923 PLLLLDEGHC--LRDQTLDICRKSGVQAELANTRAASLATAVQCVTGGLG
TH_3504|M.thermoresistible__bu QVALWAPPGTSYYSDFLMGACRRAGFEPDYVVSRVQGAATVAAPLTTGGI
. . . .
MSMEG_6849|M.smegmatis_MC2_155 -------TALMPASEARRLGNLTAVTLETAVIWQVYLASPPADRMTPATA
Mvan_0328|M.vanbaalenii_PYR-1 -------TAFMPASEARRFSDLRPVELADHVLWQVYLASRPVDHLTPATA
MAB_3308|M.abscessus_ATCC_1997 -------TIFMPASEAAQFPHLRALAVRPAIIWKIYLASAEQSQLGPASA
Mflv_3565|M.gilvum_PYR-GCK -------VAILPQSMARGGSGLHALRLAPELRGRLVWAWR-ADGANPAAR
MMAR_4157|M.marinum_M -------VGVLPQATARP-ADIIEIAIDDAQLVRPIAIGWIADRCLPSSA
MUL_4020|M.ulcerans_Agy99 -------VGVLPQATARP-ADIIEIAIDDAQLVRPIAIGWIADRCLPSSA
Mb0121|M.bovis_AF2122/97 SIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNALGPGSPVAR
Rv0117|M.tuberculosis_H37Rv SIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNALGPGSPVAR
MAV_1538|M.avium_104 -------ISLVPIDGSSYPSGVSVKPLADADAYRDVGMIWDSGRPLPRSA
MLBr_02041|M.leprae_Br4923 -------VTLLPQSAAPVESVRSKLGLAQFAAPCPGRRIGLAFRSASGRS
TH_3504|M.thermoresistible__bu --------AFVTAAAGPTMNGRVQVVDLTPPLLVPVQALWQRHTLSAIRD
:. .
MSMEG_6849|M.smegmatis_MC2_155 RLADTLLDEAVRARARRYGTRPGIDHP
Mvan_0328|M.vanbaalenii_PYR-1 RLADALLDAAADARAQ-----------
MAB_3308|M.abscessus_ATCC_1997 QLAEHLVASAHAQTNSPKT--------
Mflv_3565|M.gilvum_PYR-GCK VLGERARAMAVSPGSGAPAVVPGA---
MMAR_4157|M.marinum_M VAFRETALGCYGHRVSAAGV-------
MUL_4020|M.ulcerans_Agy99 VAFRETAFGCYGHRDSAAGV-------
Mb0121|M.bovis_AF2122/97 ALITCAQALALNEFFDTQLRGITRRR-
Rv0117|M.tuberculosis_H37Rv ALITCAQALALNEFFDTQLRGITRRR-
MAV_1538|M.avium_104 RDFIAGAAAVGHGGW------------
MLBr_02041|M.leprae_Br4923 ASYRQIAKIIGELISTEHHVRLVA---
TH_3504|M.thermoresistible__bu RILEGLG--------------------