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EYLFDTGWVDRPEVTAAALQGEIRCDVAVIGAGVGGMAAGLRLAERGVDVVVLEAGICGWGASSRNGGYL TDALSGDPRMLSALHRRRLPGVMRFGQSALRFAEDLIERHQIECDYNRVGWVSMASTTRHRAKNAERAAE VLRSLGADAEYVDGREFGLPHAFLGGVYEPHGGLCNAGKYALGLRKVLLASGARVYEQTPVQDLESSGSA VVITVPGGKVRADRVLLATNGYSADLPFAPPRLAAPLWVSLLETEPIDPERLDSTGWTNGAGFVSNNNIV SNFRKTPHNTIVFGTRNVQAPQGPLGARTTDPAVAKDLLRGFREAFPSLRDVATQKTWGGWIGMSPTLLP VAGQSSSRVLYTNGCNGYGMTQAPYLATLLADRLAGDEMHEDLRAVWYDHNVFPPNPQFSALGARALWTL DRITDQVDRLRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2651c | - | - | 100% (433) | oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2283 | - | 2e-24 | 26.20% (397) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2503c | - | 2e-05 | 37.66% (77) | putative iron-sulfur binding oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_3417 | - | 1e-28 | 27.66% (441) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4420 | gcvT_2 | 1e-05 | 28.00% (225) | aminomethyltransferase GcvT_2 |
| M. avium 104 | MAV_2749 | - | 2e-08 | 23.74% (396) | FAD dependent oxidoreductase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3663 | - | 1e-32 | 28.84% (430) | oxidoreductase |
| M. thermoresistible (build 8) | TH_1303 | - | 2e-08 | 26.27% (217) | iron-sulfur binding oxidoreductase |
| M. ulcerans Agy99 | MUL_0346 | - | 3e-05 | 41.51% (53) | 3-ketosteroid-delta-1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3170 | - | 5e-26 | 26.91% (431) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2749|M.avium_104 --------------------------------------------------
TH_1303|M.thermoresistible__bu --------------------------------------------------
Mflv_3417|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3170|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3663|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2651c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4420|M.marinum_M MGPKIVIVGAGIVGASLADELTARGVIDVTVVDRGPLFTTGGSTSHAPGL
MUL_0346|M.ulcerans_Agy99 --------------------------------------------------
MAV_2749|M.avium_104 ---------------MTSLWMSERTERPWAASQLDQGPASADVIVVGAGI
TH_1303|M.thermoresistible__bu ---------------MTSLWLADRTNQPPPPRTLDAGDRRADVVVVGAGI
Mflv_3417|M.gilvum_PYR-GCK -----------------MRAVKTVFDAPVDPALIDRSLAGAALGSVWLDI
Mvan_3170|M.vanbaalenii_PYR-1 ------------MPRRSVRAVQTVFDADVDPALVDRSLAGTTSGSVWLDI
MSMEG_3663|M.smegmatis_MC2_155 --------------------MQTVFDADVDPALLDRALAATTFGSMWLDV
MAB_2651c|M.abscessus_ATCC_199 --------------------MEYLFDTG------------------WVDR
MMAR_4420|M.marinum_M VFATNPSKTMSAFARYTVDKFSGLHHRDGAVFNRVGGLEVATTAERWADL
MUL_0346|M.ulcerans_Agy99 ---------MTVGPWGDVDRMVDVLVVGSGGGGMTAALTAASSGLDTLVI
.
MAV_2749|M.avium_104 TGLM----------------------------------------------
TH_1303|M.thermoresistible__bu TGLI----------------------------------------------
Mflv_3417|M.gilvum_PYR-GCK A-------------------------------------------------
Mvan_3170|M.vanbaalenii_PYR-1 P-------------------------------------------------
MSMEG_3663|M.smegmatis_MC2_155 P-------------------------------------------------
MAB_2651c|M.abscessus_ATCC_199 P-------------------------------------------------
MMAR_4420|M.marinum_M HRKAGWAQAWGVPGRLVGPDQCVELHPLLDRAGILGGFHTPSDGLASAVR
MUL_0346|M.ulcerans_Agy99 EKSSCFG-------------------------------------------
MAV_2749|M.avium_104 ---TAALLARAGKDVLVLEARTVGACATANTTAKISLLQGSQLSKVLPRH
TH_1303|M.thermoresistible__bu ---TAVLLARGGKDVLVVEAAYVGAGATGNTTAKISVLQGSRMSKILAKH
Mflv_3417|M.gilvum_PYR-GCK ----RPEFGTPGGP-VTCDLLVVGGGYTG-LWSALHAARRHPDRRIVLIE
Mvan_3170|M.vanbaalenii_PYR-1 ----RPQFPTPSGPPVTCDLLVIGGGYTG-LWSALHAARRHPDRRIVLIE
MSMEG_3663|M.smegmatis_MC2_155 ----RPEYPALTQP-VSCDLVVIGAGYTG-LWTALHAAERHPDRRIVVID
MAB_2651c|M.abscessus_ATCC_199 -----EVTAAALQGEIRCDVAVIGAGVGG-MAAGLRLAERG--VDVVVLE
MMAR_4420|M.marinum_M AVEAQARRAIARGAVFLAETEVQRVADHNGLVTGVHTSRGVIEADIVVCA
MUL_0346|M.ulcerans_Agy99 ----GSTALSGGGIWVPGDPAQRRAGYSPNPDDVVGYLRRITNGLVSEAR
. : : . :
MAV_2749|M.avium_104 GREV-------------------TRAYVDGNREGQEWVLGHCEAHGVAVQ
TH_1303|M.thermoresistible__bu GPRR-------------------ARQYVEGNLEGLEWLVRHCAAHGLSVQ
Mflv_3417|M.gilvum_PYR-GCK ADRI-------------------GWAASGRNGGFVDASLTHGYENGKSRW
Mvan_3170|M.vanbaalenii_PYR-1 ADRI-------------------GWAASGRNGGFVDASLTHGYENGKSRW
MSMEG_3663|M.smegmatis_MC2_155 SNRV-------------------GWAASGRNGGFVDASLTHGAENGKTRW
MAB_2651c|M.abscessus_ATCC_199 AGIC-------------------GWGASSRNGGYLTDALSGDPRMLSALH
MMAR_4420|M.marinum_M AGFWGAQLAKQVGLVLPLVPMAHQYAKTGQVAPLVGRNTEDAPASLPILR
MUL_0346|M.ulcerans_Agy99 IRQYVYSAP-------------QMLEFLEGLSAWLEFVWKPGYADYYPEL
MAV_2749|M.avium_104 REDAYTYAQSVRGVPSARAEFEACQAVGLPVVWQDDAE--VPFAYHGGVR
TH_1303|M.thermoresistible__bu REDAYTFAQSLQGVPAARTEYLAAKIAGLDVEWVDDAEGGVPFPFHGAVR
Mflv_3417|M.gilvum_PYR-GCK PDELSTLEA--MGIENLDGMQAEIAELGLDVEWERTGMLAVATEPHQVEW
Mvan_3170|M.vanbaalenii_PYR-1 PNEIDTLEA--MGVENLDGMQAEIAELGLDVEWERTGMLTVATEPHQVEW
MSMEG_3663|M.smegmatis_MC2_155 PNEIGKLDA--LGLENLDGMQADIERLGLDVEWQRTGMLTVATEPHQRAW
MAB_2651c|M.abscessus_ATCC_199 RRRLPGVMR--FGQSALRFAEDLIERHQIECDYNRVGWVSMASTTRHRAK
MMAR_4420|M.marinum_M HQDGDLYFREHVDRLGIGSYGHQPMPVDMSTLLADTAGEPMPSMLPFTEE
MUL_0346|M.ulcerans_Agy99 PGGSVLGSTINVPPIDLRKLGDDQPRLLTPLALAPRGIWLGPKELRSFYR
. .
MAV_2749|M.avium_104 LADQAQFDP---MPFLDSLAVEL--------------LGRGGRLVEHTRV
TH_1303|M.thermoresistible__bu LADQAQFDP---MPLLDSLVVEL--------------EERGGRLVQGLRV
Mflv_3417|M.gilvum_PYR-GCK LRDAAAQGQ---GTYLDQAQVRV--------------EVNSPTYRAGLFS
Mvan_3170|M.vanbaalenii_PYR-1 LADAAADGQ---GLFLDQPQVRA--------------EVDSPTYRAGLFS
MSMEG_3663|M.smegmatis_MC2_155 LAEAAAEGE---GVFLDTAEVRA--------------QVNSPTYQAGLFS
MAB_2651c|M.abscessus_ATCC_199 NAERAAEVLRSLGADAEYVDGRE--------------FGLPHAFLGGVYE
MMAR_4420|M.marinum_M DFEPAWRECVRLLPALGDTKVDEGFNGIFSFTPDGYSLLGEHRELGGFWV
MUL_0346|M.ulcerans_Agy99 IRQSWAGKAVLLKLVTRMIRARV--------------FGEQIAAIGQSLA
:
MAV_2749|M.avium_104 RRVSWRGK--GVRVHANQGSDAAGHDVELHADQLVLATG---IPILDRGG
TH_1303|M.thermoresistible__bu HKVSGRGD--GLTLHARSG---AGDEFDLRADRCVLATG---IPILDRGG
Mflv_3417|M.gilvum_PYR-GCK PDTCAIVNPARLVFELARACRDAGVEIYEHTRATRVDSGGAALRVHTDGP
Mvan_3170|M.vanbaalenii_PYR-1 ADTCAIVHPAKLALELARACREAGVEVFEHTTATRIDSGGAALRVHTDGP
MSMEG_3663|M.smegmatis_MC2_155 ADTCAIVHPAKLALELARACTEAGVQIYEHTTARSINSGGAVLRIETGDT
MAB_2651c|M.abscessus_ATCC_199 PHG-GLCNAGKYALGLRKVLLASGARVYEQTPVQDLESSGSAVVITVPGG
MMAR_4420|M.marinum_M AEAVWVTHSAGVAKAVAEWIVDGTPSIDVHECDLYRFEDFARSPRFIDET
MUL_0346|M.ulcerans_Agy99 ARLRLAMKELGVALWLDAPLVELLTDAGGAVTGAVVQTEGGRERIGVRGG
.
MAV_2749|M.avium_104 YFARVKPSRSYCLAFKVPGNIT----------------------------
TH_1303|M.thermoresistible__bu FFARLEPNRSYCLAYEVPGEIT----------------------------
Mflv_3417|M.gilvum_PYR-GCK ---VVTCRQVILATNVFPSLLR----------------------------
Mvan_3170|M.vanbaalenii_PYR-1 ---AISCRQVVLATNVFPSLLR----------------------------
MSMEG_3663|M.smegmatis_MC2_155 GDTVITARQAVLATNVFPSLLR----------------------------
MAB_2651c|M.abscessus_ATCC_199 ---KVRADRVLLATNGYSADLP----------------------------
MMAR_4420|M.marinum_M CAQAFVEVYDIVHPHQYRSALRGLRTSPFHHRQRELGAYFYEGGGWERPA
MUL_0346|M.ulcerans_Agy99 VILASGGFDHDLAWRKEHQPLVEQD-------------------------
:
MAV_2749|M.avium_104 --RPM-MISTDSPTRSVRYAPVPDGERLIVGGAGHTVGREKSPSAALDEL
TH_1303|M.thermoresistible__bu --RGM-YISTDSPTRSLRYAPTGAGDLLIVGGAGHPVGHEKNPASSVAEL
Mflv_3417|M.gilvum_PYR-GCK --RNR-LHTVPVYDYVLATEPLTGEQLDRIGWRHRQGIGDSANQFHYYRL
Mvan_3170|M.vanbaalenii_PYR-1 --RNR-LYTVPVYDYVLATEPLTETQLHRIGWQARQGIGDSANQFHYYRL
MSMEG_3663|M.smegmatis_MC2_155 --RNR-FHTVPVYDYVLATEPLTPEQLDRIGWQGRQGVGDSANQFHYYRL
MAB_2651c|M.abscessus_ATCC_199 --FAPPRLAAPLWVSLLETEPIDPERLDSTGWTNGAGFVSNNNIVSNFRK
MMAR_4420|M.marinum_M WFQANAELVRELAGRNVAFPERDDWAARYWSPIAIAEAQWTRERVALYDM
MUL_0346|M.ulcerans_Agy99 -WSFGNPAALGDGIRAGQRVGAAADLLDEAWWFPAIQWPDGRMQFMLNER
MAV_2749|M.avium_104 SAWTRKHFPGAVQTHFWSAQDYTPIDH-LPYVGPILPNSETIFVATGFNK
TH_1303|M.thermoresistible__bu DEWARRHFPGAQQRYFWSAQDYSPIDD-LPYVGPILPGNESIFVAIGFDK
Mflv_3417|M.gilvum_PYR-GCK TADNRIVWGGYDAVYHFGRRVDPAYED-RAETYRRLAAH-----------
Mvan_3170|M.vanbaalenii_PYR-1 TKDNRIVWGGYDAVYHFGRRVNAAYED-RDETYRRLAAH-----------
MSMEG_3663|M.smegmatis_MC2_155 TMDNRIVWGGYDAIYHFGRKVKDAYED-RPATYRKLAAH-----------
MAB_2651c|M.abscessus_ATCC_199 TPHNTIVFG--TRNVQAPQGPLGARTT-DPAVAKDLLRG-----------
MMAR_4420|M.marinum_M TPLTRYEVSGAGAVDLLQRLTTNDIDKGVGSVTYTLMLDETGGIRSDLTV
MUL_0346|M.ulcerans_Agy99 MMPAQFIVNGAGKRFINEAAPYMDFGHAMIAGQKSGVTHIPCWLVTDHR-
MAV_2749|M.avium_104 WGMTNGAAAALALSSRILGGRMDWARAFASWSPHELSGLATAVQANLEVG
TH_1303|M.thermoresistible__bu WGMTNGAAAALALSSRILGGRTDWAEAFASWSPHEVSGIPKAMMLNLQVG
Mflv_3417|M.gilvum_PYR-GCK FFLTFPALDDVRFTHRWAGAIDTNTRFCAHWG---LAREGRVAYVNGFTG
Mvan_3170|M.vanbaalenii_PYR-1 FFITFPQLDDVRFTHRWAGAIDTNTRFCAHWG---LAREGRVAYVNGYTG
MSMEG_3663|M.smegmatis_MC2_155 FFLTFPQLDDVRFTHRWAGAIDTNTRFCAHWG---LARNGRVAYVNGFTG
MAB_2651c|M.abscessus_ATCC_199 FREAFPSLRDVATQKTWGGWIGMSPTLLPVAG----QSSSRVLYTNGCNG
MMAR_4420|M.marinum_M ARLGTARFQVGANGPQDFDWLSRHLPQDGSVTLRDITGATCCIGVWGPAA
MUL_0346|M.ulcerans_Agy99 SFNRYVVAGHLPIPKIPGAPVPTGRKIPTAWLESGVVKAATSWAELATKI
MAV_2749|M.avium_104 FNLTKGWITPAVRIGRRSPVDGDGGVVSGPPWHLQARCRVDGTEHRVSPV
TH_1303|M.thermoresistible__bu MYLARGWLTPVTRTGDRSPDDG-CGVVSGPPWHLQARSRVDGVEHRVSPV
Mflv_3417|M.gilvum_PYR-GCK LGVGAARFAADVCLD----------LLDGTP---TPRTRLNMVRRKPIPF
Mvan_3170|M.vanbaalenii_PYR-1 LGVAATRFAADVCLD----------LLDGAP---SPRTELEMVRSKPLPF
MSMEG_3663|M.smegmatis_MC2_155 LGVAATRFAADVCLD----------LLDGRS---TERTGLEMVRKRPLPF
MAB_2651c|M.abscessus_ATCC_199 YGMTQAPYLATLLADR----------LAGDE----MHEDLRAVWYDHNVF
MMAR_4420|M.marinum_M RDLVQPLCRDDLSHQAFPYFRLLQTYLEAIPVTMLRVSYVGELGWEIYTE
MUL_0346|M.ulcerans_Agy99 GVPGGQLQATAERFNELAVYGHDDDFNRGDSVYDNYYGDPTLPNPNLYPL
.
MAV_2749|M.avium_104 CPHLGGIVNWNDADKA--------------WECPLHGSRFAPDGTLLEGP
TH_1303|M.thermoresistible__bu CPHLGGIVNWNDADQA--------------WECPLHGSRFAPDGALLEGP
Mflv_3417|M.gilvum_PYR-GCK PPEP--LASVGIQATR--------------WSLDRADHSAGRRNLLLRAL
Mvan_3170|M.vanbaalenii_PYR-1 PPEP--LASIGIQATR--------------WSLDRADHSAGRRNLLLRAL
MSMEG_3663|M.smegmatis_MC2_155 PPEP--LASIGIQATR--------------WSLDRADHSAGKRNFFLRAL
MAB_2651c|M.abscessus_ATCC_199 PPNP--QFSALGARAL--------------WTLDRITDQVDR----LRS-
MMAR_4420|M.marinum_M ASYGGALWDLLWAAGAGHQAIAAGRIAFNSLRMEKGYRAWGTDMTAEHRP
MUL_0346|M.ulcerans_Agy99 GDPPYYAFRIVLGDLG----------TSGGLRTDEYARVLRPDDTTVGGL
MAV_2749|M.avium_104 ATRDLTASR-----------------------------------------
TH_1303|M.thermoresistible__bu ATRGLTAS------------------------------------------
Mflv_3417|M.gilvum_PYR-GCK DAAGLGFDS-----------------------------------------
Mvan_3170|M.vanbaalenii_PYR-1 DAAGLGFDS-----------------------------------------
MSMEG_3663|M.smegmatis_MC2_155 DTLGLGFDS-----------------------------------------
MAB_2651c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4420|M.marinum_M DEAGLGFAVRMSKDFIGKAALVDAAARKVLQCLVFDDPAAAALGKEPVLA
MUL_0346|M.ulcerans_Agy99 YAVGNTSAPVMGRSYAGAGATIGPAMTFGFVAAKHLAARLDARRATPTTH
MAV_2749|M.avium_104 --------------------------------------------------
TH_1303|M.thermoresistible__bu --------------------------------------------------
Mflv_3417|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3170|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3663|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2651c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4420|M.marinum_M GDVCIGFVTSAGYSPTIGRTIAYAWLPAESSIGDTVTVDHRGRRYPASVH
MUL_0346|M.ulcerans_Agy99 FHGR----------------------------------------------
MAV_2749|M.avium_104 --------------
TH_1303|M.thermoresistible__bu --------------
Mflv_3417|M.gilvum_PYR-GCK --------------
Mvan_3170|M.vanbaalenii_PYR-1 --------------
MSMEG_3663|M.smegmatis_MC2_155 --------------
MAB_2651c|M.abscessus_ATCC_199 --------------
MMAR_4420|M.marinum_M QQPVVDPESTRIRR
MUL_0346|M.ulcerans_Agy99 --------------