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NSSSIEHVDVLIVGAGISGIGAAYYLQEHQPAKTFAIVEARNDIGGTWDLFRYPGIRSDSDLHTFSYEFK AWENEKAIASAGAIMSYLRETVAENSLARAIRFGHKVIESAWSTRDARWRVTIERLCSGERVTMSCEWFF CASGYYRYDEGYTPEFPGRERFAGQVVHPQQWPENLDYRGKRVLIIGSGATAVTLVPAMAETAGHVTMLQ RSPTYIIPVPSKDRIANTLPKLVGRKRAYALTRKKNVAKQRLVWHFCQRYPGAARRVIRHLNARLLPTGY PVDEHFRPDYNPWDQRLCAVPDADMFQAIRDGRASVVTDQIETFTERGIRLQSGRELEADIIVTATGLNL LAFGGIGLSVDGEPVDVSQKVAFKGFLLSDVPNFAYVFGYTNSSWTLKVGLVCEHFCRLLAHMDANGHNI CRPHAPASMPTRPLLEITAGYVKRAAAAFPHQGTEGPWRTCMDYRADRATLREGPVDDDHLQFSASAAAD TPPLALTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4352 | - | - | 100% (499) | monooxygenase-like flavoprotein |
| M. ulcerans Agy99 | MUL_5026 | ethA | e-144 | 51.23% (486) | monooxygenase EthA |
| M. ulcerans Agy99 | MUL_1880 | - | 4e-35 | 28.22% (404) | monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3884c | ethA | 1e-147 | 52.16% (485) | monooxygenase ETHA |
| M. gilvum PYR-GCK | Mflv_1123 | - | 1e-148 | 52.24% (490) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv3854c | ethA | 1e-147 | 52.16% (485) | monooxygenase ETHA |
| M. leprae Br4923 | MLBr_00065 | - | 1e-141 | 50.31% (481) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2654 | - | 1e-147 | 51.23% (486) | putative monooxygenase |
| M. marinum M | MMAR_5279 | - | 0.0 | 99.60% (499) | monooxygenase-like flavoprotein |
| M. avium 104 | MAV_0175 | - | 1e-134 | 47.77% (471) | monooxygenase, flavin-binding family protein |
| M. smegmatis MC2 155 | MSMEG_6440 | - | 1e-135 | 46.91% (486) | monooxygenase, flavin-binding family protein |
| M. thermoresistible (build 8) | TH_1149 | - | 1e-143 | 52.12% (472) | MONOOXYGENASE ETHA |
| M. vanbaalenii PYR-1 | Mvan_5683 | - | 1e-145 | 50.82% (488) | hypothetical protein Mvan_5683 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4352|M.ulcerans_Agy99 --MNSSSIEHVDVLIVGAGISGIGAAYYLQEHQPAKTFAIVEARNDIGGT
MMAR_5279|M.marinum_M --MNSSSIEHVDVLIVGAGISGIGAAYYLQEHQPAKTFAIVEARNDIGGT
MAV_0175|M.avium_104 ----------------------MSAAWHLQNRCPTKSYAILERRADLGGT
MSMEG_6440|M.smegmatis_MC2_155 ------MTEHFDVVIVGAGISGISTAWHLQDRCPTKSYVILERRANIGGT
TH_1149|M.thermoresistible__bu ----VVMTEHLDVLIVGAGISGISAAWHLQDRCPSKSYAILERRDNLGGT
Mflv_1123|M.gilvum_PYR-GCK ------MTEEVDVVVVGAGISGISAAWHLQNRCPGKSYVILEGRDDLGGT
Mvan_5683|M.vanbaalenii_PYR-1 ------MTEFVDVVIVGAGISGISAAWHLQDRCPGKSYVILERRDNLGGT
Mb3884c|M.bovis_AF2122/97 ------MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRESMGGT
Rv3854c|M.tuberculosis_H37Rv ------MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRESMGGT
MLBr_00065|M.leprae_Br4923 -MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILEKRAGMGGT
MAB_2654|M.abscessus_ATCC_1997 MTTSAPRPDYYDVVIIGAGISGIGAAAYLTREFPKKKVVLLEGRGALGGT
:.:* :* . * *. .::* * :***
MUL_4352|M.ulcerans_Agy99 WDLFRYPGIRSDSDLHTFSYEFKAWENEKAIASAGAIMSYLRETVAENSL
MMAR_5279|M.marinum_M WDLFRYPGIRSDSDLHTFSYEFKAWENEKAIASAGAIMSYLRETVAENSL
MAV_0175|M.avium_104 WDLFKYPGIRSDSDMFTLGFRFKPWRSAKSIADGASIKAYIKEAAVENRI
MSMEG_6440|M.smegmatis_MC2_155 WDLFKYPGIRSDSDMFTLGFRFKPWTSAKSIADGPSIWNYINEAAQENGI
TH_1149|M.thermoresistible__bu WDLFKYPGIRSDSDMFTLGFRFKPWTDPKAIADGPDILAYLKETAEEFGI
Mflv_1123|M.gilvum_PYR-GCK WDLFRYPGIRSDSDMFTLGFRFKPWTSEKAIADAPSIMAYLRETVAEFGI
Mvan_5683|M.vanbaalenii_PYR-1 WDLFKYPGIRSDSDMFTLGFRFKPWTSDKAIADGPDIMAYLNETVAEYGI
Mb3884c|M.bovis_AF2122/97 WDLFRYPGIRSDSDMYTLGFRFRPWTGRQAIADGKPILEYVKSTAAMYGI
Rv3854c|M.tuberculosis_H37Rv WDLFRYPGIRSDSDMYTLGFRFRPWTGRQAIADGKPILEYVKSTAAMYGI
MLBr_00065|M.leprae_Br4923 WDLFRYPGIRSDSDMYTLGFRFRPWTKCQAIADGKPILEYIKSTAVMHGI
MAB_2654|M.abscessus_ATCC_1997 WDLFRYPGIRSDSDLHTFAYEFKSWRHKNAIADAPLILDYLKETVDEYGL
****:*********:.*:.:.*:.* ::**.. * *:..:. :
MUL_4352|M.ulcerans_Agy99 ARAIRFGHKVIESAWSTRDARWRVTIERL-CSGERV--TMSCEWFFCASG
MMAR_5279|M.marinum_M ARAIRFGHKVIEAAWSTRDARWRVTIERL-YSGERV--TMSCEWFFCASG
MAV_0175|M.avium_104 EPHIRYRHRVVAADWSDADNRWTVTVE---HDGQRS--EITCSFLFACTG
MSMEG_6440|M.smegmatis_MC2_155 DKHIRTNHRVLGADWSDAENRWTITVE---ADGEQK--QITASFLSVCSG
TH_1149|M.thermoresistible__bu DEHIRYRHRVVSANWSDPDNKWILQVE---RDGEQV--EMTCSFLFACSG
Mflv_1123|M.gilvum_PYR-GCK DRHIRYGHRMVAADWSDADNRWTVHVE---RGGERV--EISARYLMACSG
Mvan_5683|M.vanbaalenii_PYR-1 DKHIRYGQNVKSADWSDADNRWTVRVD---RAGEEV--EISARYLMACSG
Mb3884c|M.bovis_AF2122/97 DRHIRFHHKVISADWSTAENRWTVHIQ---SHGTLS--ALTCEFLFLCSG
Rv3854c|M.tuberculosis_H37Rv DRHIRFHHKVISADWSTAENRWTVHIQ---SHGTLS--ALTCEFLFLCSG
MLBr_00065|M.leprae_Br4923 DKYIRLNHKVTGADWSSIENRWTVQVE---NNGTPR--MISCSFLFLCSG
MAB_2654|M.abscessus_ATCC_1997 ADIIKYRHNVIAAAWSSDDAEWVLTVDVTDPDGSVRSEVIKAGWVYAGTG
*: :.: : ** : .* : :: * :.. :. :*
MUL_4352|M.ulcerans_Agy99 YYRYDEGYTPEFPGRERFAGQVVHPQQWPENLDYRGKRVLIIGSGATAVT
MMAR_5279|M.marinum_M YYRYDEGYTPEFPGRERFAGQVVHPQQWPENLDYRGKRVLIIGSGATAVT
MAV_0175|M.avium_104 YYNYDEGYSPTFPGAEDFGGTIVHPQHWPEDLDYAGKRIVVIGSGATAIT
MSMEG_6440|M.smegmatis_MC2_155 YYNYDQGYSPEFPGADDFAGQIIHPQHWPEDLDYAGKKIVVIGSGATAVT
TH_1149|M.thermoresistible__bu YYNYDEGYSPEFPGADDFEGTIVHPQHWPEDLDYAGKRIVVIGSGATAVT
Mflv_1123|M.gilvum_PYR-GCK YYDYDRGYSPEFAGAQDFEGPIIHPQHWPEDLDYTGKRVVVIGSGATAVT
Mvan_5683|M.vanbaalenii_PYR-1 YYNYDEGYSPDFPGSEDFEGTLIHPQHWPEDLDYAGKRIVVIGSGATAVT
Mb3884c|M.bovis_AF2122/97 YYNYDEGYSPRFAGSEDFVGPIIHPQHWPEDLDYDAKNIVVIGSGATAVT
Rv3854c|M.tuberculosis_H37Rv YYNYDEGYSPRFAGSEDFVGPIIHPQHWPEDLDYDAKNIVVIGSGATAVT
MLBr_00065|M.leprae_Br4923 YYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVIGSGATAVT
MAB_2654|M.abscessus_ATCC_1997 YYRYDKAYTPEFEGREEFEGDIIHPQFWPEGYDHSGKNIVVIGSGATAIT
** *:..*:* * * : * * ::*** ***. *: .*.:::*******:*
MUL_4352|M.ulcerans_Agy99 LVPAMAET---AGHVTMLQRSPTYIIPVPSKDRIANTLPKLVGRKRAYAL
MMAR_5279|M.marinum_M LVPAMAET---AGHVTMLQRSPTYIIPVPSKDRIANTLPKLVGRKRAYAL
MAV_0175|M.avium_104 LIPALVNSG--AGHVTMLQRSPTYIGSLPGVDPFAERANRLLPDRLAHMA
MSMEG_6440|M.smegmatis_MC2_155 LIPSLVNGG--AAHVTMLQRSPTYIGSLPLVDPVAEKTNKYLPKNLAHFV
TH_1149|M.thermoresistible__bu LIPALAETG--AGHVTMLQRSPTYIGSLPLVDPIAVKVNKYLPPKMASVV
Mflv_1123|M.gilvum_PYR-GCK LVPALADSG--AGHVTMLQRSPTYIGALPDVDPFTVRTNKTLPTGAAYVV
Mvan_5683|M.vanbaalenii_PYR-1 LIPALANSG--AGHVTMLQRSPTFIAALPDVDPFTVATNKRLPAKVAYVL
Mb3884c|M.bovis_AF2122/97 LVPALADSG--AKHVTMLQRSPTYIVSQPDRDGIAEKLNRWLPETMAYTA
Rv3854c|M.tuberculosis_H37Rv LVPALADSG--AKHVTMLQRSPTYIVSQPDRDGIAEKLNRWLPETMAYTA
MLBr_00065|M.leprae_Br4923 LVPALANSG--AKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPDKYAYTA
MAB_2654|M.abscessus_ATCC_1997 LIPSMLKGDDAAEHVTMLQRTPTYIMSMPRTDALSLKLTRLLGERRGYLA
*:*:: . * *******:**:* . * * .: : : .
MUL_4352|M.ulcerans_Agy99 TRKKNVAKQRLVWHFCQRYPGAARRVIRHLNARLLPTGYPVDEHFRPDYN
MMAR_5279|M.marinum_M TRKKNVAKQRLVWHFCQRYPGAARRVIRHLNARLLPTGYPVDEHFRPDYN
MAV_0175|M.avium_104 NRWKAIAFSTFQYQLSRKAPAYMRKTLMTMAKRRLPEGYDVEKHFGPRYN
MSMEG_6440|M.smegmatis_MC2_155 NRWKAIAFSTAQYQLARKFPNYMRKTLMTMAQRRLPEGFDVQKHFGPRYN
TH_1149|M.thermoresistible__bu NRWKAIIFSTFQYQLSRKFPNYMRRTLMRMAERRLPPGYDVEKHFGPRYN
Mflv_1123|M.gilvum_PYR-GCK NRWKSILFQSVQYQLSRRFPRFMRRTLMTMAQRRLPEGYDIARHFGPSYN
Mvan_5683|M.vanbaalenii_PYR-1 NRWKSILQQSVQYQVARKFPDFFRKQLLTMAKHRLPEGYDVNKHFNPRYN
Mb3884c|M.bovis_AF2122/97 VRWKNVLRQAAVYSACQKWPRRMRKMFLSLIQRQLPEGYDVRKHFGPHYN
Rv3854c|M.tuberculosis_H37Rv VRWKNVLRQAAVYSACQKWPRRMRKMFLSLIQRQLPEGYDVRKHFGPHYN
MLBr_00065|M.leprae_Br4923 VRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPKGYDVQKHFGPHYN
MAB_2654|M.abscessus_ATCC_1997 TRWKNVLLDWVVVELMTRFPKAARRLIRHLNTKELPAGFDVDRHFNPPYD
* * : . : * *. : : ** *: : .** * *:
MUL_4352|M.ulcerans_Agy99 PWDQRLCAVPDADMFQAIRDGRASVVTDQIETFTERGIRLQSGRELEADI
MMAR_5279|M.marinum_M PWDQRLCAVPDADMFQAIRDGRASVVTDQIETFTERGIRLQSGRELEADI
MAV_0175|M.avium_104 VWDERLCLAPDGDFFRTIRHGKADVVTDTIDRFTTTGIRLNSGEELPADI
MSMEG_6440|M.smegmatis_MC2_155 PWDERLCLAPNGDLFKTIRAGKADVVTDTIAKFTETGIKLTSGEELTADI
TH_1149|M.thermoresistible__bu PWDERLCLAPNGDLFRAIRHGKADVVTDTIDTFTKTGIRLTSGTELEADI
Mflv_1123|M.gilvum_PYR-GCK PWDQRLCLAPNGDLFETIRTGRADVVTDTIERFDRTGITLSSGQHLDADI
Mvan_5683|M.vanbaalenii_PYR-1 PWDERVCLAPNGDLFKTIRAGKADVVTDTIERFTKTGIQLASGRHLDADI
Mb3884c|M.bovis_AF2122/97 PWDQRLCLVPNGDLFRAIRHGKVEVVTDTIERFTATGIRLNSGRELPADI
Rv3854c|M.tuberculosis_H37Rv PWDQRLCLVPNGDLFRAIRHGKVEVVTDTIERFTATGIRLNSGRELPADI
MLBr_00065|M.leprae_Br4923 PWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDRFTSTGIRLKSGNELRADI
MAB_2654|M.abscessus_ATCC_1997 PWDQRLCLAPDGDFFTSIREGRASVVTDRIRRFTKNGIELESGEELPADV
*::*:* .*:.*:* :** * ..:*** * * ** * ** .* **:
MUL_4352|M.ulcerans_Agy99 IVTATGLNLLAFGGIGLSVDGEPVDVSQKVAFKGFLLSDVPNFAYVFGYT
MMAR_5279|M.marinum_M IVTATGLNLLAFGGIGLSVDGEPVDVSQKVAFKGFLLSDVPNFAYVFGYT
MAV_0175|M.avium_104 IVTATGLNMQLLGGVTPTRNGDPVDLTSLMTYKGLMFSGMPNFAITFGYT
MSMEG_6440|M.smegmatis_MC2_155 IITATGLNMQLFGGASLTRNGQEVDLTETMTYKGLMLSGVPNMAITFGYT
TH_1149|M.thermoresistible__bu IITATGLNLQLFGGAEIKRNGQPVELTETMAYKGMMLSGMPNMAFTIGYT
Mflv_1123|M.gilvum_PYR-GCK IVTATGLNLRLFGGAVISRNGEVIELSETMAYKGMLLTGMPNLAFTIGYT
Mvan_5683|M.vanbaalenii_PYR-1 IVTATGLNLQLFGGATISRNGEAIELNDTMAYKGMLLTDMPNLAFTIGYT
Mb3884c|M.bovis_AF2122/97 IITATGLNLQLFGGATATIDGQQVDITTTMAYKGMMLSGIPNMAYTVGYT
Rv3854c|M.tuberculosis_H37Rv IITATGLNLQLFGGATATIDGQQVDITTTMAYKGMMLSGIPNMAYTVGYT
MLBr_00065|M.leprae_Br4923 IVTATGLNLQLFGGAVATVDGQPVDLAQTMSYKGMMLSGLPNMIYTVGYT
MAB_2654|M.abscessus_ATCC_1997 IVTATGLNMRLFGGVDLTVDGRPIDLSSSVVYRGLLLSGLPNWMMAIGYT
*:******: :** . :* ::: : ::*::::.:** ..***
MUL_4352|M.ulcerans_Agy99 NSSWTLKVGLVCEHFCRLLAHMDANGHNICRPHAP-ASMPTRPLLEITAG
MMAR_5279|M.marinum_M NSSWTLKVGLVCEHFCRLLAHMDANGHNICRPHAP-ASMPTRPLLEITAG
MAV_0175|M.avium_104 NASWTLKADLVSEFVCRLLNYMDAKGFDFVEPQHPGEDVDALPFMDFTPG
MSMEG_6440|M.smegmatis_MC2_155 NASWTLKADLVSEFICRVLNYMDDNGFDRVEPQHPGDAVDALPFMDFNPG
TH_1149|M.thermoresistible__bu NASWTLKADLVSEFVCRVLNHMDEHGYDVVEPQHPGDSVEERPLLDFTPG
Mflv_1123|M.gilvum_PYR-GCK NASWTLKADLVSEFFCRIINYMDEHSYTRMEPRHPGGGVDERPLLDFTPG
Mvan_5683|M.vanbaalenii_PYR-1 NASWTLKADLVSEFFCRIINYMDANSYDRVEPRHPGSSVDERPLMDFTPG
Mb3884c|M.bovis_AF2122/97 NASWTLKADLVSEFVCRLLNYMDDNGFDTVVVERPGSDVEERPFMEFTPG
Rv3854c|M.tuberculosis_H37Rv NASWTLKADLVSEFVCRLLNYMDDNGFDTVVVERPGSDVEERPFMEFTPG
MLBr_00065|M.leprae_Br4923 NASWTLKADLVSEFFCRLLNYMNANDFDTVAVEYPGSDVEERPFMDFTPG
MAB_2654|M.abscessus_ATCC_1997 KSSWTLKISLLGKSLIELLHHMDTHGYDTVAP-YAAEGVGTRSILDLDAG
::***** .*: : . .:: :*: :.. . : .:::: .*
MUL_4352|M.ulcerans_Agy99 YVKRAAAAFPHQGT-EGPW-RTCMDYRADRATLREGPVDDDHLQFSA---
MMAR_5279|M.marinum_M YVKRAAAAFPHQGT-EGPW-RTCMDYRADRATLREGPVDDDHLQFSA---
MAV_0175|M.avium_104 YFRRSMHLLPKSGS-RAPW-RLKQNYFFDMRTIRRGRVDDEGLKFAK---
MSMEG_6440|M.smegmatis_MC2_155 YFRRAMDSLPKSGS-RAPW-RLKQNYFFDLRMIRYDKVDEESLHFTK---
TH_1149|M.thermoresistible__bu YVLRALDRLPPPXXXRMWWTRCRRSRFAAGPPAWRSTTRRRSSRPRP---
Mflv_1123|M.gilvum_PYR-GCK YVLRALDHLPKAGS-RAPW-RLKQNYLLDLQLIRRGRVDDEALEFGQ---
Mvan_5683|M.vanbaalenii_PYR-1 YVLRALDYLPKAGS-RAPW-RLKQNYLMDLQLIRRGKVDDEALAFSR---
Mb3884c|M.bovis_AF2122/97 YVLRSLDELPKQGS-RTPW-RLNQNYLRDIRLIRRGKIDDEGLRFAK---
Rv3854c|M.tuberculosis_H37Rv YVLRSLDELPKQGS-RTPW-RLNQNYLRDIRLIRRGKIDDEGLRFAK---
MLBr_00065|M.leprae_Br4923 YVLRSLDALPKQGS-RTPW-RLNQNYLRDIRLIRRGKVADEGLLFAK---
MAB_2654|M.abscessus_ATCC_1997 YMQRSKHSLPRQGD-AMPW--QMRNVFLEDRKMYRGSIIDDNLHFSSRLE
*. *: :* * . .
MUL_4352|M.ulcerans_Agy99 ------------SAAADTPPLALTG--
MMAR_5279|M.marinum_M ------------SAAADTPPLALTG--
MAV_0175|M.avium_104 ------------KRAPVAV--------
MSMEG_6440|M.smegmatis_MC2_155 ------------HRAAVSASSS-----
TH_1149|M.thermoresistible__bu ------------GRWGSTGCG------
Mflv_1123|M.gilvum_PYR-GCK ------------SAVTTTIPSSSL---
Mvan_5683|M.vanbaalenii_PYR-1 ------------HPAQVTASA------
Mb3884c|M.bovis_AF2122/97 ------------RPAPVGV--------
Rv3854c|M.tuberculosis_H37Rv ------------RPAPVGV--------
MLBr_00065|M.leprae_Br4923 ------------KTTPVTV--------
MAB_2654|M.abscessus_ATCC_1997 RELKDSGSNSPDRRTQISRASSGGATS