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NSIWLEGRSGLVARVPLAPDDTTQTVDIAVIGAGITGLTTALLLARAGLEVVVLEARSAGDGTTGNSTGK ISALHGTKLSRIAHRHGHAVARAYTTGNTEGRDWLLRYCEEHGVPTQTEDAYTYAQTREGTAGARDEWNA CLQAGLPVRWETTADTPFPYYGGVRLPDQAQFNPAQLVESMVAQLEDHGAHFFSGMRVRSISGRGPLRIK GDYAHDAGAGEFALEAQRCVLATGTPILDRGGFFAKLTANRSYCMSFDVPGPITRAMYLSVDAPLRSVRY APSSTGDRLVVGGAGHVVGHPAHAREALRELAGWAQTHYPGATRTHSWAAQDYATISELPYAGPLLPGGK RIYLATGYDKWGMTNGIAASLALSSQILGGRMDWANAFASWSALDLRAIPAAIRLGSRVARDFASGWATA MLTSRPEHAPVCTHLGGITTWNDAEDIWECPLHGSCFDSGGSVLWGPATEPLDRLPADGAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2503c | - | - | 100% (482) | putative iron-sulfur binding oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2283 | - | 2e-07 | 27.05% (207) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2651c | - | 2e-05 | 37.66% (77) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3567 | - | 2e-05 | 34.21% (76) | 3-ketosteroid-delta-1-dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0732 | - | 1e-144 | 50.69% (505) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv3537 | - | 2e-05 | 34.21% (76) | 3-ketosteroid-delta-1-dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_2694 | - | 1e-06 | 33.00% (100) | flavoprotein |
| M. avium 104 | MAV_2749 | - | 1e-138 | 49.01% (506) | FAD dependent oxidoreductase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0637 | - | 1e-146 | 50.59% (508) | iron-sulfur binding oxidoreductase |
| M. thermoresistible (build 8) | TH_1303 | - | 1e-140 | 49.60% (504) | iron-sulfur binding oxidoreductase |
| M. ulcerans Agy99 | MUL_3063 | - | 3e-07 | 31.67% (120) | flavoprotein |
| M. vanbaalenii PYR-1 | Mvan_0117 | - | 1e-145 | 49.90% (505) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2749|M.avium_104 --------------------------------------------------
TH_1303|M.thermoresistible__bu --------------------------------------------------
MSMEG_0637|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0732|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0117|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2503c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3567|M.bovis_AF2122/97 --------------------------------------------------
Rv3537|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2694|M.marinum_M --------------------------------------------------
MUL_3063|M.ulcerans_Agy99 MNLSVRSPTQIAWVTPDLDATEAAFTGLLGARKWVRIPDVHFAPDSCSYR
MAV_2749|M.avium_104 --------------------------------------------------
TH_1303|M.thermoresistible__bu --------------------------------------------------
MSMEG_0637|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0732|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0117|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2503c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3567|M.bovis_AF2122/97 --------------------------------------------------
Rv3537|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2694|M.marinum_M --------------------------------------------------
MUL_3063|M.ulcerans_Agy99 GKPADFVASISLSYLGDMQLELISPVRGENIYSDFPRDCGPGLHHICLEV
MAV_2749|M.avium_104 --------------------------------------------------
TH_1303|M.thermoresistible__bu --------------------------------------------------
MSMEG_0637|M.smegmatis_MC2_155 ----------------------------------------MSGRSFRFGH
Mflv_0732|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0117|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2503c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3567|M.bovis_AF2122/97 --------------------------------------------------
Rv3537|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2694|M.marinum_M --------------------------------------------------
MUL_3063|M.ulcerans_Agy99 EGPEQLEIALAEAADHGASVVQRGSMPGGIQFAYVAAPQAGVPFVEIAYF
MAV_2749|M.avium_104 ---------MTSLWMSERTE-RPWAASQLDQGPASADVIVVGAGITGLMT
TH_1303|M.thermoresistible__bu ---------MTSLWLADRTN-QPPPPRTLDAGDRRADVVVVGAGITGLIT
MSMEG_0637|M.smegmatis_MC2_155 DGYREAMTAATSLWLAGRAE-RPTPP-YLDETNCTADVVVVGAGITGLIT
Mflv_0732|M.gilvum_PYR-GCK ---------MSSLWTDGRVE-TPSRPDEVAAVR-TADVVVVGAGITGLTT
Mvan_0117|M.vanbaalenii_PYR-1 ---------MSSLWTDGRIE-IASRPDEVAQAH-TADVLVVGAGITGLTT
MAB_2503c|M.abscessus_ATCC_199 ---------MNSIWLEGRSGLVARVPLAPDDTTQTVDIAVIGAGITGLTT
Mb3567|M.bovis_AF2122/97 ------------------------------MTVQEFDVVVVGSGAAGMVA
Rv3537|M.tuberculosis_H37Rv ------------------------------MTVQEFDVVVVGSGAAGMVA
MMAR_2694|M.marinum_M ----------------------------MTSWTDDVDVVVIGFGIAGGCA
MUL_3063|M.ulcerans_Agy99 SPEIKAFYDYIKRAALNTEIPATVSSDTVTSWTDDVDVVVIGFGIAGGCA
*: *:* * :* :
MAV_2749|M.avium_104 AALLARAGKDVLVLEARTVGACATANTTAKISLLQGSQLSKVLPRHGR--
TH_1303|M.thermoresistible__bu AVLLARGGKDVLVVEAAYVGAGATGNTTAKISVLQGSRMSKILAKHGP--
MSMEG_0637|M.smegmatis_MC2_155 AVLLARAGKDVLVLEAYTAGAGTTGNTTAKVSLLQGTKMSKILRKHGA--
Mflv_0732|M.gilvum_PYR-GCK ALLLARAGKKVVVVEARHIGACATGNTTGKVSVLQGSKLANVAGKHGT--
Mvan_0117|M.vanbaalenii_PYR-1 AVLLARAGKKVLVVEARHVGACATGNTTGKVSVLQGTKLARIRAKHGP--
MAB_2503c|M.abscessus_ATCC_199 ALLLARAGLEVVVLEARSAGDGTTGNSTGKISALHGTKLSRIAHRHGH--
Mb3567|M.bovis_AF2122/97 ALVAAHRGLSTVVVEKAPHYGGSTARSGGGVWIPN-NEVLKRRGVRDTPE
Rv3537|M.tuberculosis_H37Rv ALVAAHRGLSTVVVEKAPHYGGSTARSGGGVWIPN-NEVLKRRGVRDTPE
MMAR_2694|M.marinum_M AVAAAAAGARVLVLERAAAAGGTTSLAGGHFYLGGGTAVQQATGHSDTPD
MUL_3063|M.ulcerans_Agy99 AVAAAAAGARVLVLERAAAAGGTTSLAGGHFYLGGGTAVQQATGHSDTPD
* * * .:*:* :*. : . . . : . .
MAV_2749|M.avium_104 ----------------EVTRAYVDGNREGQEWVLGHCEAHGVAVQREDAY
TH_1303|M.thermoresistible__bu ----------------RRARQYVEGNLEGLEWLVRHCAAHGLSVQREDAY
MSMEG_0637|M.smegmatis_MC2_155 ----------------KVAGQYVQGNLEGQEWLAGYCDANGLSLQREDAY
Mflv_0732|M.gilvum_PYR-GCK ----------------DTLRAYVLGNTEGRDWLLRYCDEHGISAQREDDH
Mvan_0117|M.vanbaalenii_PYR-1 ----------------DVLSAYVTGNAEGRDWLIRYHDDHGLAYQREDDH
MAB_2503c|M.abscessus_ATCC_199 ----------------AVARAYTTGNTEGRDWLLRYCEEHGVPTQTEDAY
Mb3567|M.bovis_AF2122/97 AARTYLHGIVGEIVEPERIDAYLDRGPEMLSFVLKH-TPLKMCWVPGYSD
Rv3537|M.tuberculosis_H37Rv AARTYLHGIVGEIVEPERIDAYLDRGPEMLSFVLKH-TPLKMCWVPGYSD
MMAR_2694|M.marinum_M EMYKYLVAVS-RQPDHAKIRAYCDGSVEHFNWLEDLGFQFERSYFPGKAV
MUL_3063|M.ulcerans_Agy99 EMYKYLAAVS-RQPDHAKIRAYCDGSVEHFNWLEDLGFQFERSYFPGKAV
* . * .::
MAV_2749|M.avium_104 TYAQSVRGVPSARAEFE---ACQAVGLPVVWQDDAE--------------
TH_1303|M.thermoresistible__bu TFAQSLQGVPAARTEYL---AAKIAGLDVEWVDDAEG-G-----------
MSMEG_0637|M.smegmatis_MC2_155 TYAQSEKGLASARAEYD---ACREVGLDADWVDAADAPD-----------
Mflv_0732|M.gilvum_PYR-GCK AYAQNEKGLGTARKILA---ACREANLDAQWVDEAD--------------
Mvan_0117|M.vanbaalenii_PYR-1 SYAQAESGLSTARDVLA---ACREAGVDAQWVDEAD--------------
MAB_2503c|M.abscessus_ATCC_199 TYAQTREGTAGARDEWN---ACLQAGLPVRWETTAD--------------
Mb3567|M.bovis_AF2122/97 YYPEAPGGRPGGRSIEPKPFNARKLGADMAGLEPAYGKVPLNVVVMQQDY
Rv3537|M.tuberculosis_H37Rv YYPEAPGGRPGGRSIEPKPFNARKLGADMAGLEPAYGKVPLNVVVMQQDY
MMAR_2694|M.marinum_M IQPNTEGLMFTG-NEKVWPFFEKAVPAPRGHKVPVPGDT-----------
MUL_3063|M.ulcerans_Agy99 IQPNTEGLMFTG-NEKVWPFFEKAVPAPRGHKVPVPGDT-----------
.: . .
MAV_2749|M.avium_104 -----------------------------------VPFAYHGGVRLADQA
TH_1303|M.thermoresistible__bu -----------------------------------VPFPFHGAVRLADQA
MSMEG_0637|M.smegmatis_MC2_155 -----------------------------------VPFPFAGGVRLPDQA
Mflv_0732|M.gilvum_PYR-GCK -----------------------------------VPFPFAGGVRLREQA
Mvan_0117|M.vanbaalenii_PYR-1 -----------------------------------VPFPFQGGVRVREQA
MAB_2503c|M.abscessus_ATCC_199 -----------------------------------TPFPYYGGVRLPDQA
Mb3567|M.bovis_AF2122/97 VRLNQLKRHPRGVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQR
Rv3537|M.tuberculosis_H37Rv VRLNQLKRHPRGVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQR
MMAR_2694|M.marinum_M ----------------------------------GGASMVIDLLLKRAAS
MUL_3063|M.ulcerans_Agy99 ----------------------------------GGASMVIDLLLKRGAS
. :
MAV_2749|M.avium_104 QFDPMPFLDSLAVELLGRGGRLVEHTRVRRVSWRGKGVRVHANQGS---D
TH_1303|M.thermoresistible__bu QFDPMPLLDSLVVELEERGGRLVQGLRVHKVSGRGDGLTLHARSG-----
MSMEG_0637|M.smegmatis_MC2_155 QFDPMPLLDKLIVELDERNGRLVEGTRVLGVSQDSSGLKIKVRSH-----
Mflv_0732|M.gilvum_PYR-GCK QIDPMPYLSSVVAELESHGGTVLQGVRATSVSG-VRSVTVTLRMTTRPDD
Mvan_0117|M.vanbaalenii_PYR-1 QLDPVPYLGSLVTELEKHGGTLLQGVRATTVTG-TDPVRVRFRLTDTAQD
MAB_2503c|M.abscessus_ATCC_199 QFNPAQLVESMVAQLEDHGAHFFSGMRVRSISG-RGPLRIKGDYAH---D
Mb3567|M.bovis_AF2122/97 AGVPVELNTAFTDLFVENGVVSGVYVRDSHEAESAEPQLIRARRG---VI
Rv3537|M.tuberculosis_H37Rv AGVPVELNTAFTDLFVENGVVSGVYVRDSHEAESAEPQLIRARRG---VI
MMAR_2694|M.marinum_M LGVQIRYETGATELIVD-GSGTAARVAGVMWKRFTETGAIKAKS----VI
MUL_3063|M.ulcerans_Agy99 LGVQIRYETGATELIVA-GSGTAARVAGVMWKRFTETGAIKAKS----VI
: . :
MAV_2749|M.avium_104 AAGHDVELHADQLVLATGIPILDRGGYFARVKPSRSYCLAFKVPGNITRP
TH_1303|M.thermoresistible__bu -AGDEFDLRADRCVLATGIPILDRGGFFARLEPNRSYCLAYEVPGEITRG
MSMEG_0637|M.smegmatis_MC2_155 -TGTELDVRAGQCVLATGIPILDRGGFFARLSPHRSYCLAFRVPGAVTRG
Mflv_0732|M.gilvum_PYR-GCK TRDEDFSITAERCVLATGIPVLDRGFFFARAEPMRSYCMAFDVPGELTRS
Mvan_0117|M.vanbaalenii_PYR-1 TRDEQFSVTARHCVLATGTPILDRGMFFARVEAKRSYCLAFDVPGDITTP
MAB_2503c|M.abscessus_ATCC_199 AGAGEFALEAQRCVLATGTPILDRGGFFAKLTANRSYCMSFDVPGPITRA
Mb3567|M.bovis_AF2122/97 LACGGFEHNEQMRIKYQRAPITTEWTVGASANTGDGILAAEKLGAALDLM
Rv3537|M.tuberculosis_H37Rv LACGGFEHNEQMRIKYQRAPITTEWTVGASANTGDGILAAEKLGAALDLM
MMAR_2694|M.marinum_M IAAGGFVMNPEMVAKYTPKLAEKPFVLGNTYDDGLGIRMGVSAGGATEHM
MUL_3063|M.ulcerans_Agy99 IAAGGFVMNPEMVAKYTPKLAEKPFVLGNTYDDGLGIRMGVSAGGATEHM
. . . .
MAV_2749|M.avium_104 MMISTDSPTRSVRYAPVPDGER-----LIVGGAG-HTVGREKSPSAALDE
TH_1303|M.thermoresistible__bu MYISTDSPTRSLRYAPTGAGDL-----LIVGGAG-HPVGHEKNPASSVAE
MSMEG_0637|M.smegmatis_MC2_155 MYISTDSPTRSVRYAPTADGDR-----LIVGGAG-HTVGRRSHPSDDVDE
Mflv_0732|M.gilvum_PYR-GCK MYISVDSPTRSVRYAPTPGGEK-----LIVGGAG-HPVGRADDPKSAVDE
Mvan_0117|M.vanbaalenii_PYR-1 MFLSVDSPTRSVRYAPTAAGSK-----LIVGGAG-HPVGRADNPSKAVAE
MAB_2503c|M.abscessus_ATCC_199 MYLSVDAPLRSVRYAPSSTGDR-----LVVGGAG-HVVGHPAHAREALRE
Mb3567|M.bovis_AF2122/97 DDAWWGPTVPLVGKPWFALSERNSPGSIIVNMSGKRFMNESMPYVEACHH
Rv3537|M.tuberculosis_H37Rv DDAWWGPTVPLVGKPWFALSERNSPGSIIVNMSGKRFMNESMPYVEACHH
MMAR_2694|M.marinum_M DQIFVTAPP---YPPSILLTG------VIVNKLGRRFVAEDSYHSRTAGF
MUL_3063|M.ulcerans_Agy99 DQIFVTAPP---YPPSILLTG------VIVNKLGRRFVAEDSYHSRTAGF
.. . ::*. * : : .
MAV_2749|M.avium_104 LSAWTRKHFPG---AVQTHFWSAQDYTPIDHLPYVGPILPNSETIFVATG
TH_1303|M.thermoresistible__bu LDEWARRHFPG---AQQRYFWSAQDYSPIDDLPYVGPILPGNESIFVAIG
MSMEG_0637|M.smegmatis_MC2_155 LASWAKVHWPG---AIQTHYWSAQDYTPVDELPYVGPLLPGNEKVFVATG
Mflv_0732|M.gilvum_PYR-GCK LGRWATLHYPG---AVQTHFWSAQDYHPADELPYVGPLLPKLENILVATG
Mvan_0117|M.vanbaalenii_PYR-1 LSHWAALHYPG---AVQTHYWSAQDYHPDDEVPFIGPLLPMHESVLVATG
MAB_2503c|M.abscessus_ATCC_199 LAGWAQTHYPG---ATRTHSWAAQDYATISELPYAGPLLPGGKRIYLATG
Mb3567|M.bovis_AF2122/97 MYGGEHGQGPGPGENIPAWLVFDQRYRDRYIFAGLQPGQRIPSRWLDSGV
Rv3537|M.tuberculosis_H37Rv MYGGEHGQGPGPGENIPAWLVFDQRYRDRYIFAGLQPGQRIPSRWLDSGV
MMAR_2694|M.marinum_M IMD---------QPDSAAYLIVDEAHLQHPKMP-LVP------------L
MUL_3063|M.ulcerans_Agy99 IMD---------QPDSAAYLIVDEAHLQHPKMP-LVP------------L
: : : .. *
MAV_2749|M.avium_104 FNKWGMTNGAAAALALSSRILGGRMDWARAFASWS-PHELSGLATAVQAN
TH_1303|M.thermoresistible__bu FDKWGMTNGAAAALALSSRILGGRTDWAEAFASWS-PHEVSGIPKAMMLN
MSMEG_0637|M.smegmatis_MC2_155 FDKWGMTNGTAAALALSSRILGGRMDWSQAFDSWS-PHELSGIPTALKVN
Mflv_0732|M.gilvum_PYR-GCK FDKWGMTNGVAAALALTSRILGGRMDWARAFASWS-PHELSGIPTALQMN
Mvan_0117|M.vanbaalenii_PYR-1 FDKWGMTNGVAAALALSARILGGRMDWAQTFASWR-LHELRGVPTALQAN
MAB_2503c|M.abscessus_ATCC_199 YDKWGMTNGIAASLALSSQILGGRMDWANAFASWS-ALDLRAIPAAIRLG
Mb3567|M.bovis_AF2122/97 IVQADTLAELAGKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRY
Rv3537|M.tuberculosis_H37Rv IVQADTLAELAGKAGLPADELTATVQRFNAFARSGVDEDYHRGESAYDRY
MMAR_2694|M.marinum_M IDGWESVAEMEAALGIPDGNLVATLDRYNTYAARGEDPDFHKQPEFLAPQ
MUL_3063|M.ulcerans_Agy99 IDGWESVAEMEAALGIPDCNLVAALDRYNTYAARGEDPDFHKQPEFLAPQ
. .:. * . : .:: :
MAV_2749|M.avium_104 LEVGFNLTKGWITPAVRIGRRSPVDGDGGVVSGPPWHLQARCRVDGTEHR
TH_1303|M.thermoresistible__bu LQVGMYLARGWLTPVTRTGDRSPDDG-CGVVSGPPWHLQARSRVDGVEHR
MSMEG_0637|M.smegmatis_MC2_155 LEVGFNMAKGWVTPILRRGDGVPDDG--GVVAGPPWRMEACSVVDGVERR
Mflv_0732|M.gilvum_PYR-GCK FEVGLHLAKGWVTPVTTP-AGPPAEG-EGIVTGPPWNLRACSVVDGVERT
Mvan_0117|M.vanbaalenii_PYR-1 MKVGLHLANGWLAPLTSS-AEEPADG-TGVVSGPPWRLRATSVVDGVQRT
MAB_2503c|M.abscessus_ATCC_199 SRVARDFASGWATAMLTS-----------------------------RPE
Mb3567|M.bovis_AF2122/97 YGDPSNKPNPNLGEVGHPPYYGAKMV--PGDLGTKGGIRTDVNGRALRDD
Rv3537|M.tuberculosis_H37Rv YGDPSNKPNPNLGEVGHPPYYGAKMV--PGDLGTKGGIRTDVNGRALRDD
MMAR_2694|M.marinum_M DKGPWGAFDMSLGKAMYAGFT-------------LGGLATSVDGEVLRSD
MUL_3063|M.ulcerans_Agy99 DKGPWGAFDMSLGKAMYAGFT-------------LGGLATSVDGEVLRSD
.
MAV_2749|M.avium_104 VSPVCPHLGGIVNWNDADKAWECPLHGSRFAPDGTLLEGPATRDLTASR-
TH_1303|M.thermoresistible__bu VSPVCPHLGGIVNWNDADQAWECPLHGSRFAPDGALLEGPATRGLTAS--
MSMEG_0637|M.smegmatis_MC2_155 VSPVCPHLGGIVEWNDSDEAWECPLHGSRFAPDGTLLEGPATHGLTPAP-
Mflv_0732|M.gilvum_PYR-GCK VSPVCPHLGGIVEWNNIDHAWECPLHGSRFAPDGTLLEGPATRGLT----
Mvan_0117|M.vanbaalenii_PYR-1 VSPVCPHLGGIVKWNDSDRAWECPLHGSRFAPDGALLEGPATRGLSGCRP
MAB_2503c|M.abscessus_ATCC_199 HAPVCTHLGGITTWNDAEDIWECPLHGSCFDSGGSVLWGPATEPLDRLPA
Mb3567|M.bovis_AF2122/97 GSIIDGLYAAGNVSAPVMG-HTYPGPGGTIGPAMTFGYLAALHIADQAGK
Rv3537|M.tuberculosis_H37Rv GSIIDGLYAAGNVSAPVMG-HTYPGPGGTIGPAMTFGYLAALHIADQAGK
MMAR_2694|M.marinum_M GSVVAGLYAAGACASNIAQDGKGYASGTQLGEGSFFGRRAGAHAAAHAGA
MUL_3063|M.ulcerans_Agy99 GSVVAGLYAAGACASNIAQDGKGYASGTQLGEGSFFGRRAGAHAAAHACA
: : .. * : . .. .
MAV_2749|M.avium_104 ------------
TH_1303|M.thermoresistible__bu ------------
MSMEG_0637|M.smegmatis_MC2_155 ------------
Mflv_0732|M.gilvum_PYR-GCK ------------
Mvan_0117|M.vanbaalenii_PYR-1 AQLRNVSEGLRP
MAB_2503c|M.abscessus_ATCC_199 DGAR--------
Mb3567|M.bovis_AF2122/97 R-----------
Rv3537|M.tuberculosis_H37Rv R-----------
MMAR_2694|M.marinum_M RVAP--------
MUL_3063|M.ulcerans_Agy99 RVAP--------