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SVTPNAGCVDVVIVGAGISGLGAAYRIIERNPQLTYTILERRARIGGTWDLFRYPGVRSDSSIFTLSFPY EPWTREEGIADGAHIREYLTDMAHKYGIDRHIEFNSYVRAADWDSSTDTWTVTFEQNGVHKHYRSRFVFF GSGYYNYDEGYTPDFGGIEKFGGAVVHPQHWPEDLDYTGKKIVVIGSGATAVTLIPSLTDRAEKVTMLQR SPTYLISASKYSTFAAVVRKALPPKTSHLIVRMYNALLEAVFWFLSRKTPVFVKWLLRRTAIKNLPEGYD IETHFTPRYNPWDQRLCLIPDADLYNAITSGRAEVVTDHIDHFDATGIALKSGGHLDADIIVTATGLQLQ ALGGAAISLDGVEIDPRDRFVYKAHMLEDVPNLFWCVGYTNASWTLRADMTARATAKLLAHMAAHGHTRA APHLGDEPMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVRQNYLADAIDYRFDRIEEAMVFGAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0565c | - | - | 100% (486) | PROBABLE MONOOXYGENASE |
| M. tuberculosis H37Rv | Rv3854c | ethA | e-133 | 49.04% (471) | monooxygenase ETHA |
| M. tuberculosis H37Rv | Rv3083 | - | e-119 | 44.51% (483) | monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0580c | - | 0.0 | 100.00% (486) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4499 | - | 0.0 | 65.21% (480) | FAD dependent oxidoreductase |
| M. leprae Br4923 | MLBr_00065 | - | 1e-134 | 48.66% (485) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2294c | - | 1e-144 | 50.21% (486) | monooxygenase |
| M. marinum M | MMAR_0917 | - | 0.0 | 80.36% (494) | flavin-binding monooxygenase |
| M. avium 104 | MAV_4576 | - | 0.0 | 79.32% (498) | monooxygenase, flavin-binding family protein |
| M. smegmatis MC2 155 | MSMEG_2038 | - | 0.0 | 63.87% (476) | monooxygenase, flavin-binding family protein |
| M. thermoresistible (build 8) | TH_2757 | - | 0.0 | 63.71% (474) | PUTATIVE FAD dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_5026 | ethA | 1e-134 | 48.83% (471) | monooxygenase EthA |
| M. vanbaalenii PYR-1 | Mvan_1867 | - | 0.0 | 65.55% (476) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4499|M.gilvum_PYR-GCK --------MDQ---------LYPETESTDVLIVGAGISGIGAAYRIQERN
Mvan_1867|M.vanbaalenii_PYR-1 --------MDQ---------RHSETEFSDVLIIGAGISGIGAAYRIQERN
TH_2757|M.thermoresistible__bu VAEEVIMTLDQGPAVEQSAHHGDAAEYFDVLIIGAGISGIGAAYRIKEKN
MSMEG_2038|M.smegmatis_MC2_155 --------MGAT--------ESDDPAYTDVLIIGAGISGINAAYRIHEKC
Rv0565c|M.tuberculosis_H37Rv ------MSVTPNAG------------CVDVVIVGAGISGLGAAYRIIERN
Mb0580c|M.bovis_AF2122/97 ------MSVTPNAG------------CVDVVIVGAGISGLGAAYRIIERN
MMAR_0917|M.marinum_M ------MSVTPQEAQRT----PVERSLLDVVIVGAGISGLGAAYRLLESN
MAV_4576|M.avium_104 ------MTVTPQEAADHG---AAEADYFDVLIVGAGISGIDAAYRITERN
MAB_2294c|M.abscessus_ATCC_199 ------MSDMPR------------DELVDVLIVGAGISGINAAIRLSG--
MLBr_00065|M.leprae_Br4923 ------MVVMA------------ETEYLDVVIVGAGISGVSAAWHLQDRC
MUL_5026|M.ulcerans_Agy99 -----------------------MTEHLDVVIVGAGISGVSAAWHLQDRC
**:*:******:.** ::
Mflv_4499|M.gilvum_PYR-GCK PQLTYTVLERRSRIGGTWDLHRYPGIRSDSDIFTLSFPWEPWDRPENVAD
Mvan_1867|M.vanbaalenii_PYR-1 PQLTYTLLERRSRIGGTWDLHRYPGIRSDSDIFTLSFPWEPWTRPENVAD
TH_2757|M.thermoresistible__bu PGVSYAILERRSRIGGTWDLFRYPGIRSDSDILTLSYPWEPWTRPENVAD
MSMEG_2038|M.smegmatis_MC2_155 PGLTYTLLERRERIGGTWDLFRYPGIRSDSDIFTLSYPYEPWTRPENVAD
Rv0565c|M.tuberculosis_H37Rv PQLTYTILERRARIGGTWDLFRYPGVRSDSSIFTLSFPYEPWTREEGIAD
Mb0580c|M.bovis_AF2122/97 PQLTYTILERRARIGGTWDLFRYPGVRSDSSIFTLSFPYEPWTREEGIAD
MMAR_0917|M.marinum_M PELTYTILERRERIGGTWDLFRYPGVRSDSSIFTLSFPFEPWTRREGVAD
MAV_4576|M.avium_104 PQLSYAILERRARIGGTWDLFRYPGVRSDSSIFTLSFPFEPWTRKEGVAD
MAB_2294c|M.abscessus_ATCC_199 AGRSFHIVERRERIGGTWDLFRYPGIRSDSDIYTLSFGYHPWHERNTIAD
MLBr_00065|M.leprae_Br4923 PNKSYVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAIAD
MUL_5026|M.ulcerans_Agy99 PTKSYAILEKRAAMGGTWELFRYPGIRSDSDMHTLGFRFRPWTERQAIAD
. :: ::*:* :****:*.****:****.: **.: :.** . : :**
Mflv_4499|M.gilvum_PYR-GCK GEDIRQYLVDAARKHGIDRHIHFDTRVLSADWDSTADVWTVRTEC---NG
Mvan_1867|M.vanbaalenii_PYR-1 GEDIRSYLTETAHKHGIDRHIRFDTRVISADWDSGTDTWTVQTEQ---DG
TH_2757|M.thermoresistible__bu GPDIRQYLVDTARKHGIYDNIRFDTHVLSADWDSSTDTWTVQTTE---DG
MSMEG_2038|M.smegmatis_MC2_155 GGDIRAYLTETARKYGIDRHIRFNTHVLSADWDSATDTWTLHTEQ---DG
Rv0565c|M.tuberculosis_H37Rv GAHIREYLTDMAHKYGIDRHIEFNSYVRAADWDSSTDTWTVTFEQ---NG
Mb0580c|M.bovis_AF2122/97 GAHIREYLTDMAHKYGIDRHIEFNSYVRAADWDSSTDTWTVTFEQ---NG
MMAR_0917|M.marinum_M GEHIREYLANTAHKYGIDGHIQFNSYVRAADWDSGTDSWTVTFEQ---DG
MAV_4576|M.avium_104 GVHIREYLTATAHKYGIDRHIRFNSYVRSADWDSTSDTWTVTVEDGARDG
MAB_2294c|M.abscessus_ATCC_199 GADIRDYLEHAASDYDIDGHITFSAKVTSADFGTDTDIWSVRVDT---PA
MLBr_00065|M.leprae_Br4923 GKPILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVEN---NG
MUL_5026|M.ulcerans_Agy99 GKPILEYVKGTAAMYGIDKHIRLNQKVISADWSNAQNRWTLQIES---NG
* * *: * :.* * :. * .**:.. : *:: .
Mflv_4499|M.gilvum_PYR-GCK VPRTYRTRFLFFGTGYYDYDNPYRPEFPGLESFEGPVVHPQHWPEDLDCT
Mvan_1867|M.vanbaalenii_PYR-1 VPHTYRTRFLFFATGYYDYDHPYRPDFPGLDSFSGTVVHPQHWPEDLDYA
TH_2757|M.thermoresistible__bu LPRTYRSRFVFFGTGYYDYDEPYAPEFPGIENFKGEVVHPQHWPESLDYA
MSMEG_2038|M.smegmatis_MC2_155 QPRDYRARFVFFGTGYYNYDEPYTPDFPGINDFRGEVVHPQFWPESLDHT
Rv0565c|M.tuberculosis_H37Rv VHKHYRSRFVFFGSGYYNYDEGYTPDFGGIEKFGGAVVHPQHWPEDLDYT
Mb0580c|M.bovis_AF2122/97 VHKHYRSRFVFFGSGYYNYDEGYTPDFGGIEKFGGAVVHPQHWPEDLDYT
MMAR_0917|M.marinum_M VQRQCRSRFVFFASGYYNYDQGYTPDFPGIEGFTGTVVHPQHWPADLDYT
MAV_4576|M.avium_104 ERKLYRARFLFFGSGYYNYDEGYTPDFPGIEEFTGTVVHPQHWPEDLDYT
MAB_2294c|M.abscessus_ATCC_199 GPTTYRAKFLYLCTGYYNYDDGYTPEFPGVEKFAGRLIHPQHWPDDLDCS
MLBr_00065|M.leprae_Br4923 TPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYA
MUL_5026|M.ulcerans_Agy99 AMSAVTCSFLFLCSGYYNYDQGYTPNFAGAQDFAGSIIHPQHWPEDLDYD
*::: :***:*:. * * * * : * * ::***.** .**
Mflv_4499|M.gilvum_PYR-GCK GKKVAVIGSGATAISMIPALAES-AERVTMVQRSPTYLLSGQRINPVVNL
Mvan_1867|M.vanbaalenii_PYR-1 GKNVVVIGSGATAISLIPSLTKQ-AGHVTMLQRSPTYLLSGQRINPVVNL
TH_2757|M.thermoresistible__bu GKRMVVIGSGATAISLIPSLTEQ-AEHVTMLQRTPTYLLSSPRINPVVQA
MSMEG_2038|M.smegmatis_MC2_155 GKRVVVIGSGATAISLVPAMART-AGHVTMLQRSPTYMMSSPRINPAVQA
Rv0565c|M.tuberculosis_H37Rv GKKIVVIGSGATAVTLIPSLTDR-AEKVTMLQRSPTYLISASKYSTFAAV
Mb0580c|M.bovis_AF2122/97 GKKIVVIGSGATAVTLIPSLTDR-AEKVTMLQRSPTYLISASKYSTFAAV
MMAR_0917|M.marinum_M GKKVVVIGSGATAVTLIPSMAEQ-AAKVTMLQRSPTYLISSSKYSKFAAI
MAV_4576|M.avium_104 GKKVVVIGSGATAVTLLPSLSDR-AAKVTMLQRSPTYLISASKYGKVAAV
MAB_2294c|M.abscessus_ATCC_199 GKEITVIGSGATAITLVPSLARA-GAKVNMLQRSPSYIYPIARVDAVVDV
MLBr_00065|M.leprae_Br4923 AKNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAAR
MUL_5026|M.ulcerans_Agy99 GKNVVVIGSGASAVTLVPALANSGAKHVTMLQRSPTYIVSQPERDSIAER
.*.:.******:*::::*::: . :*.*:**:*:*: . . .
Mflv_4499|M.gilvum_PYR-GCK LRKVPPRKLGYRLAWLYNVLFIVAVYGVARKAPRISRRLIRAVAKHYLPE
Mvan_1867|M.vanbaalenii_PYR-1 LRRVPPRKLGYRLAWLYNVLFIVSVYGIARKAPRFSRKIIRAVAKHYLPE
TH_2757|M.thermoresistible__bu LRKIPPRWLGYRLAWLYNLIFVVAVYAIAKAAPRFSRWFIRTVAKIYLPK
MSMEG_2038|M.smegmatis_MC2_155 IRKVLPRRVAHQVVRVRNAMVQYVAYHLFRAAPRLGRWVIRKATISVLPK
Rv0565c|M.tuberculosis_H37Rv VRKALPPKTSHLIVRMYNALLEAVFWFLSRKTPVFVKWLLRRTAIKNLPE
Mb0580c|M.bovis_AF2122/97 VRKALPPKTSHLIVRMYNALLEAVFWFLSRKTPVFVKWLLRRTAIKNLPE
MMAR_0917|M.marinum_M ARKVLPRKASHLTIRTYNALLEAVLWFLARKLPGFIKWLLRRIAIKNLPA
MAV_4576|M.avium_104 ARKVLPRKPAHLVIRMYSALTEAVFFALSRKAPRLVRWLLRRKAINSLPP
MAB_2294c|M.abscessus_ATCC_199 MRKVFPLSIVQHFARIWLGGFNWIMYQVCRKAPGFAKWFLRRRITKLLPA
MLBr_00065|M.leprae_Br4923 LNRWLPDKYAYTAVRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPK
MUL_5026|M.ulcerans_Agy99 LNRWLPENMAYAMVRWKNVLRQAAVYGACRKWPRRMRKNFMGLAQRQLPE
.: * : : * : : **
Mflv_4499|M.gilvum_PYR-GCK GYPVDTHFKPRYDPWDQRLCLILSGDFYDAIARGRAEVVTDEIDHIDAHG
Mvan_1867|M.vanbaalenii_PYR-1 GYPVDTHFNPSYDPWDQRLCLILSGDFYDAIAKGRAEVVTDRVDHIDANG
TH_2757|M.thermoresistible__bu DYPVDVHFNPPYDPWDQRLCLILSGDFYKAIREGRATVVTDNIDHIDETG
MSMEG_2038|M.smegmatis_MC2_155 GYPVDVHFKPRYNPWDQRMCLVLDKDIFEGISSGRFDVVTDHIDHFDADG
Rv0565c|M.tuberculosis_H37Rv GYDIETHFTPRYNPWDQRLCLIPDADLYNAITSGRAEVVTDHIDHFDATG
Mb0580c|M.bovis_AF2122/97 GYDIETHFTPRYNPWDQRLCLIPDADLYNAITSGRAEVVTDHIDHFDATG
MMAR_0917|M.marinum_M GYDVDTHFKPNYNPWDQRLCLIPDADLYSAVAGGRAEVVTDHIDHFDATG
MAV_4576|M.avium_104 GYAVDIHFKPRYNPWDQRMCLIPDADLYNAITAGRADVVTDHIDHFDATG
MAB_2294c|M.abscessus_ATCC_199 GYPVDVHFAPRYNPWDQRVCADTDGDLFEAISNGGVRMVTDTIDTFTSAG
MLBr_00065|M.leprae_Br4923 GYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDRFTSTG
MUL_5026|M.ulcerans_Agy99 GYDVRKHFGPHYNPWDQRLCLVPNGDLFRAIRHGQVDVVTDTIDRFTPTG
.* : ** * *:**:**:* . *:: .: * :*** :* : *
Mflv_4499|M.gilvum_PYR-GCK LVLKSGRRIDADVLVTATGLQLQALGGIEISIDGTEVKPADRFVYKEHLL
Mvan_1867|M.vanbaalenii_PYR-1 IVLQSGKRIDADVIVTATGIQLQALGGVVISVDGDEVKPADRFVYKEHLL
TH_2757|M.thermoresistible__bu IVLRSGNRIDADIIVTATGLQLQALGGVRLSIDGEEIKPQDRFVFKEHML
MSMEG_2038|M.smegmatis_MC2_155 IVLTSGNRIDADIVVTATGLQLQALGGITLRVDGDEVKPTERFVYKEFLL
Rv0565c|M.tuberculosis_H37Rv IALKSGGHLDADIIVTATGLQLQALGGAAISLDGVEIDPRDRFVYKAHML
Mb0580c|M.bovis_AF2122/97 IALKSGGHLDADIIVTATGLQLQALGGAAISLDGVEIDPRDRFVYKAHML
MMAR_0917|M.marinum_M IALESGRHLDADIIVTATGLQLQALGGVQISLDGTEINPCDRFVYKAHML
MAV_4576|M.avium_104 IALRSGAHLDADIIITATGLQLQALGGATISLDGNEIKTNDRFVYKAHML
MAB_2294c|M.abscessus_ATCC_199 IRLGSGQELPADVIITATGLNLQIFGGIALSVDGSPVDAPNRFIYKGYLI
MLBr_00065|M.leprae_Br4923 IRLKSGNELRADIIVTATGLNLQLFGGAVATVDGQPVDLAQTMSYKGMML
MUL_5026|M.ulcerans_Agy99 IRLNSGQQLPADIIVTATGLNLQLFGGAAVTVDGESVDLTKAMAYKGMML
: * ** .: **:::****::** :** :** :. . : :* ::
Mflv_4499|M.gilvum_PYR-GCK EDVPNLAWCVGYINASWTLRADLTARAVAKLLAHMDSHGYTHAYPHLGGV
Mvan_1867|M.vanbaalenii_PYR-1 EDVPNMAWCVGYINASWTLRADLTARAVAKLLAYMDSHGYTHAYPHLGGT
TH_2757|M.thermoresistible__bu EDVPNLAWCIGYINASWTLRADLTARAFARLIAHMRKHGYTHGYPHLGDT
MSMEG_2038|M.smegmatis_MC2_155 EDVPNMAWCIGYTNASWTLRADMTAKAVAKLLAYMGSHGYTHAYPHKGST
Rv0565c|M.tuberculosis_H37Rv EDVPNLFWCVGYTNASWTLRADMTARATAKLLAHMAAHGHTRAAPHLGDE
Mb0580c|M.bovis_AF2122/97 EDVPNLFWCVGYTNASWTLRADMTARATAKLLAHMAAHGHTRAAPHLGDE
MMAR_0917|M.marinum_M EGVPNLFWCVGYTNASWTLRADMTARATAKLLAHMAANGYTHAYPDRGNE
MAV_4576|M.avium_104 EDVPNLFWCVGYTNASWTLRADITARATAKLLEHMTTHGYTHAYPHRGNE
MAB_2294c|M.abscessus_ATCC_199 EGVPNAAWSVGYTNASWTLRADLSARAVVRLLDYMDRHGYTHAYPDRHGE
MLBr_00065|M.leprae_Br4923 SGLPNMIYTVGYTNASWTLKADLVSEFFCRLLNYMNANDFDTVAVEYPGS
MUL_5026|M.ulcerans_Agy99 SGLPNMAYTVGYTNASWTLKADLVSEFVCRLLNYMDANDYESVVVERPGS
..:** : :** ******:**: :. :*: :* :.. . .
Mflv_4499|M.gilvum_PYR-GCK PMEEKPAWNINAGYVHRAPHVLPKSGTHRPWNVRHNYVLDAVDQRFDRI-
Mvan_1867|M.vanbaalenii_PYR-1 SMPEKPAWNINAGYVHRAVHVLPKSGTHRPWNVRHNYVLDAIDHRVDRI-
TH_2757|M.thermoresistible__bu PMKEKPAWNINAGYVKRALHALPKSGTRRPWNVRHNYLLDVVDHRFDRI-
MSMEG_2038|M.smegmatis_MC2_155 PIAEKRTWDLEAGYIQRSEHALPRSGTKRPWHVRHNYLLDAIDHRFDRI-
Rv0565c|M.tuberculosis_H37Rv PMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVRQNYLADAIDYRFDRI-
Mb0580c|M.bovis_AF2122/97 PMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVRQNYLADAIDYRFDRI-
MMAR_0917|M.marinum_M AMPEKPSWDIQAGYVLRSLHALPKSGTKRPWNVRQNYFADAIDYRFDRI-
MAV_4576|M.avium_104 PMTEKPSWDINAGYVLRSVHALPKSGTKRPWNVRQNYLADAIDYRFDRI-
MAB_2294c|M.abscessus_ATCC_199 ELEARPFFNLSSGYVTRGDAHMPRSGVSGPWAIRHNYVLDFLAFHRDRI-
MLBr_00065|M.leprae_Br4923 DVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRDIRLIRRGKVA
MUL_5026|M.ulcerans_Agy99 DVQECPFMEFTPGYVLRVIDELPKQGSRKPWRLNQDYLRDIHLIRRGKID
: :: .**: * :*:.* ** :.::*. * : .::
Mflv_4499|M.gilvum_PYR-GCK DESMVFGRVSPKLHSSSEMSSEDLLERNFGA---------
Mvan_1867|M.vanbaalenii_PYR-1 EESMVFGRAASKSPSSSDIPGEDLLEGKVVG---------
TH_2757|M.thermoresistible__bu DESMVFGRVGAPLKQPA-----------------------
MSMEG_2038|M.smegmatis_MC2_155 DESMVFGRAPAAVQVPASAPSPAPPSAPRAGASAVEPAAS
Rv0565c|M.tuberculosis_H37Rv EEAMVFGAA-------------------------------
Mb0580c|M.bovis_AF2122/97 EEAMVFGAA-------------------------------
MMAR_0917|M.marinum_M DEAMMFGRAADRAPLAG-----------------------
MAV_4576|M.avium_104 EEAMVFGRAADRAALAG-----------------------
MAB_2294c|M.abscessus_ATCC_199 DENMQFGIAKSKAVSSAA----------------------
MLBr_00065|M.leprae_Br4923 DEGLLFAKKTTPVTV-------------------------
MUL_5026|M.ulcerans_Agy99 DEGLRFAKKPVAVPV-------------------------
:* : *.