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MSNQVPEKMQAVVCHGPHDYRLEEVAVPQRKPGEALIRVEAVGICASDLKCYHGAAKFWGDENRPAWAET MVIPGHEFVGRVVELDDEAAQRWGIAVGDRVVSEQIVPCWECLFCKRGQYHMCQPHDLYGFKRRTPGAMA SYMVYPAEALVHKVSPDIPAQHAAFAEPLSCSLHAVERAQITFEDTVVVAGCGPIGLGMIAGAKAKSPMR VIALDMAPDKLKLAEKCGADLTINIAEQDAEKIIKDLTGGYGADVYIEGTGHTSAVPQGLNLLRKLGRYV EYGVFGSDVTVDWSIISDDKELDVLGAHLGPYCWPAAIKMIESGALPMDEICTHQFPLTEFQKGLDLVAS GKESVKVSLIPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3265 | - | - | 100% (362) | arabitol-phosphate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2882 | - | 4e-38 | 32.22% (360) | 5-exo-alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3094 | - | 2e-37 | 30.55% (347) | oxidoreductase, zinc-binding dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1557 | adh | 2e-31 | 31.58% (342) | alcohol dehydrogenase adh |
| M. gilvum PYR-GCK | Mflv_0638 | - | 7e-38 | 28.97% (359) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1530 | adh | 2e-31 | 31.58% (342) | alcohol dehydrogenase adh |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-25 | 26.86% (350) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2041c | - | 7e-26 | 27.89% (337) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_3350 | adhE2 | 2e-27 | 28.29% (350) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. avium 104 | MAV_1614 | - | 5e-22 | 29.02% (386) | alcohol dehydrogenase B |
| M. thermoresistible (build 8) | TH_2786 | - | 9e-28 | 30.85% (363) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_1292 | adhE2 | 2e-27 | 28.29% (350) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. vanbaalenii PYR-1 | Mvan_0527 | - | 1e-37 | 28.97% (359) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3350|M.marinum_M ---MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLT
MUL_1292|M.ulcerans_Agy99 ---MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLT
MLBr_01784|M.leprae_Br4923 ---MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLT
MAV_1614|M.avium_104 -----MKSRAAILHDVGGPWSVEEFELDPPRAGEVLVQMAAAGLCHSDDH
TH_2786|M.thermoresistible__bu -----VKTKAAVLFEFGAPWSIEEVDLDPPAEGEVLVAWEASGLCHSDEH
Mflv_0638|M.gilvum_PYR-GCK -------MRAAIYHGR-EDVRIEELPDPSPRAGEVVIEVARAGICGTDLH
Mvan_0527|M.vanbaalenii_PYR-1 -------MRAAIYHGR-EDVRIEELPDPSPRAGEVVIEVARAGICGTDLH
Mb1557|M.bovis_AF2122/97 --MSDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCGTDHE
Rv1530|M.tuberculosis_H37Rv --MSDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCGTDHE
MAB_2041c|M.abscessus_ATCC_199 ------MIAEAMVLTGPRSLQRRQMIIPDVGDRGAILRVEACGLCGTDHE
MSMEG_3265|M.smegmatis_MC2_155 MSNQVPEKMQAVVCHGPHDYRLEEVAVPQRKPGEALIRVEAVGICASDLK
.: : .:: *:* :*
MMAR_3350|M.marinum_M YREG------------GINDEYPFLLGHEAAGTVEAVGPGVTN---VEPG
MUL_1292|M.ulcerans_Agy99 YREG------------GINDEYPFLLGHEAAGTVEAVGPGVTN---VEPG
MLBr_01784|M.leprae_Br4923 YREG------------GINDRYPFLLGHEAAGTVEVVGPGVTA---VEPG
MAV_1614|M.avium_104 ILKGDMSAPNEVMRSLGLPTMFPTIGGHEGSGIVREVGEGVTD---FAPG
TH_2786|M.thermoresistible__bu LRLGDFGGP--------IP-EVAMIGGHEGAGRIVEVGPGVRG---LKEG
Mflv_0638|M.gilvum_PYR-GCK EYIAG-----------PMHAAPGVVIGHEYSGTVVGVGSGVRE---FTEG
Mvan_0527|M.vanbaalenii_PYR-1 EYIAG-----------PMHAAPGVVIGHEYSGTVVGVGSGVRE---FTEG
Mb1557|M.bovis_AF2122/97 QYTG------------ELAGGFAFVPGHETVGTIAAIGPRAEQRWGVSAG
Rv1530|M.tuberculosis_H37Rv QYTG------------ELAGGFAFVPGHETVGTIAAIGPRAEQRWGVSAG
MAB_2041c|M.abscessus_ATCC_199 QFTG------------HLPAGFSFVPGHEIVGIVEHVGAAAGQRWGVQAG
MSMEG_3265|M.smegmatis_MC2_155 CYHGAAKFWGDENR--PAWAETMVIPGHEFVGRVVELDDEAAQRWGIAVG
. : *** * : :. . . *
MMAR_3350|M.marinum_M DFVILNWRAVCGQCRACKRGRPSYCFDTFNAEQKMTLTDGT---------
MUL_1292|M.ulcerans_Agy99 DFVILNWRAVCGQCRACKRGRPSYCFDTFNAEQKMTLTDGT---------
MLBr_01784|M.leprae_Br4923 DFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGT---------
MAV_1614|M.avium_104 DHVVMSFVAVCGQCRWCASGMEYLCDVGIGTMIPGMPTDGTFRHHTAGGG
TH_2786|M.thermoresistible__bu DHVVASFIPACGRCRFCATGQSNLCDLG-ALLMTGTQPDGTFRRRVNSK-
Mflv_0638|M.gilvum_PYR-GCK DRVCGVGVFGCGECGFCKQGAEALCGAVGFIGFAVN--------------
Mvan_0527|M.vanbaalenii_PYR-1 DRVCGVGVFGCGECGFCKQGAEALCGAVGFIGFAVN--------------
Mb1557|M.bovis_AF2122/97 DRVAVEVFQSCRQCANCRGGEYRRCVRHGLADMYGFIPVDR---------
Rv1530|M.tuberculosis_H37Rv DRVAVEVFQSCRQCANCRGGEYRRCVRHGLADMYGFIPVDR---------
MAB_2041c|M.abscessus_ATCC_199 QRVAVEVFRSCRDCPECRRGEYRRCAVNGIATMFGFVDVEI---------
MSMEG_3265|M.smegmatis_MC2_155 DRVVSEQIVPCWECLFCKRGQYHMCQPHDLYGFKRRTP------------
: * * * * * *
MMAR_3350|M.marinum_M ELTPALGIGAFADKTLVH-SGQCTKVDPAADPAVAGLLGCGVMAGLGAAV
MUL_1292|M.ulcerans_Agy99 ELTPALGIGAFADKTLVH-SGQCTKVDPAADPAVAGLLGCGVMAGLGAAV
MLBr_01784|M.leprae_Br4923 ELTPALGIGAFADKTLVH-SGQCTKVDPAADPAVAGLLGCGVMAGLGAAI
MAV_1614|M.avium_104 NLGHIAKIGAFAEHTVVS-TNSLVKIEQQLPLAPSALLSCAIPTGYGSAA
TH_2786|M.thermoresistible__bu NVGAMSFVGSFSQYGSIP-EASVVKIDDDIPLARACLLGCGITTGWGSAV
Mflv_0638|M.gilvum_PYR-GCK --------GALARYASLP-TKALFRIPDEISLAEAAVVEP-IASAY-HAV
Mvan_0527|M.vanbaalenii_PYR-1 --------GALARYASLP-TKALFRIPDEISLAEAAVVEP-IASAY-HAV
Mb1557|M.bovis_AF2122/97 ---EPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATLFNP-LGAGIRWGV
Rv1530|M.tuberculosis_H37Rv ---EPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATLFNP-LGAGIRWGV
MAB_2041c|M.abscessus_ATCC_199 ---GAGLWGGYATHVELPWDAMLLPIAEDMDPVLATLFNP-LGAGIQWGA
MSMEG_3265|M.smegmatis_MC2_155 --------GAMASYMVYPAEALVHKVSPDIPAQHAAFAEP--LSCSLHAV
*. : : : . : .
MMAR_3350|M.marinum_M NTGGVTRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDNT---KLEW
MUL_1292|M.ulcerans_Agy99 NTGGVTRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDNT---KLEW
MLBr_01784|M.leprae_Br4923 NTAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDT---KLEW
MAV_1614|M.avium_104 NRAGVCGGDAVVVIGAGGIGTGAIQGARISGAAQIVAVDPVEF---KQKS
TH_2786|M.thermoresistible__bu NTAAVEPGDTVVVWGCGGIGSGAIQGARVAGAEHIVAIDLVES---KREK
Mflv_0638|M.gilvum_PYR-GCK RRSGLAAGGTVFIAGAGPIGLALVQFSLAQGATQVIVSEVSAT---RRVA
Mvan_0527|M.vanbaalenii_PYR-1 RRSGLAAGGTVFIAGAGPIGLALVQFSLAQGATQVIVSEVSAT---RRVA
Mb1557|M.bovis_AF2122/97 TIPETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLAL
Rv1530|M.tuberculosis_H37Rv TIPETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLAL
MAB_2041c|M.abscessus_ATCC_199 TLPDTKAGDVVAILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAI
MSMEG_3265|M.smegmatis_MC2_155 ERAQITFEDTVVVAGCGPIGLGMIAGAKAKSPMRVIALDMAPD---KLKL
..* : * * * : .. : :
MMAR_3350|M.marinum_M ARAFGATHTVNARELDVVETIQDLTGGFGVDVVIDAVG--RPETWKQAFY
MUL_1292|M.ulcerans_Agy99 ARAFGATHTVNARELDVVETIQDLTGGFGVDVVIDAVG--RPETWKQAFY
MLBr_01784|M.leprae_Br4923 ARTFGATHTVNALELEVVKTIQDLTSGFGVDVVIDTVG--RPETWKQAFY
MAV_1614|M.avium_104 ALRFGATHSVAT-IAEALDLVRDLTYGVMADAVVVSPSLITADDVRDALK
TH_2786|M.thermoresistible__bu AMQFGATHFVTS-VEEATALVAELTRGVMADSVILTVGVLRGTMIEEGLN
Mflv_0638|M.gilvum_PYR-GCK AHRVGATRVIDPLAEDAVEVVRTLTNGNGVDISFDAAG--VQPALDAALG
Mvan_0527|M.vanbaalenii_PYR-1 AHRVGATRVIDPLAEDAVEVVRMLTNGNGVDISFDAAG--VQPALDAALG
Mb1557|M.bovis_AF2122/97 AAQFGADLAVDVAIDDPVAALTEQTGG-LADVVVDVTAK-APAAFAQAIA
Rv1530|M.tuberculosis_H37Rv AAQFGADLAVDVAIDDPVAALTEQTGG-LADVVVDVTAK-APAAFAQAIA
MAB_2041c|M.abscessus_ATCC_199 ARSFGVDLPIDVSQDDAATALQRETGGRLADVVVDVTAK-APSAFADAVG
MSMEG_3265|M.smegmatis_MC2_155 AEKCGADLTINIAEQDAEKIIKDLTGGYGADVYIEGTG--HTSAVPQGLN
* *. : : : * * .* . . ..
MMAR_3350|M.marinum_M ARDLAGTVVLVGVP-TPDMRLDMPLVDFFSRGGALKSSWYGDCLPERDFP
MUL_1292|M.ulcerans_Agy99 ARDLAGTVVLVGVP-TPDMRLDMPLVDFFSRGGALKSSWYGDCLPERDFP
MLBr_01784|M.leprae_Br4923 ARDLAGTVVLVGVP-TPDMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFP
MAV_1614|M.avium_104 LTRKGGTCVLTGMTSQLTRSVNIELQDFILMNKTLAGTIFGSCNPRADIA
TH_2786|M.thermoresistible__bu MTRKGGAVVMTAIAPITDQAVTMSMGAATLFQKRVLGSLYGEANPRADIP
Mflv_0638|M.gilvum_PYR-GCK VLRPRGRLMVVAIW---EAPAGIDINRSVMREANIGFSFCYEAQR--QVP
Mvan_0527|M.vanbaalenii_PYR-1 VLRPRGRLMVVAIW---EAPAGIDINRSVMREANIGFSFCYEAQR--QVP
Mb1557|M.bovis_AF2122/97 LARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALG---VDATAYR
Rv1530|M.tuberculosis_H37Rv LARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALG---VDATAYR
MAB_2041c|M.abscessus_ATCC_199 LARPGGTIVVAGTRGGG-GAPRFEPDLLVYKELHVVGALG---VEYPAYR
MSMEG_3265|M.smegmatis_MC2_155 LLRKLGRYVEYGVFG-----SDVTVDWSIISDDKELDVLG-AHLGPYCWP
* : . .
MMAR_3350|M.marinum_M TLIDLYLQGRLPLDKFVSEQIGLGGIE-EAFEKMHAGKVLRSVVVL----
MUL_1292|M.ulcerans_Agy99 TLIDLYLQGRLPLDKFVSEQIGLGGIE-EAFEKMHAGKVLRSVVVL----
MLBr_01784|M.leprae_Br4923 TLVDLYLQGRLPLGKFVSERIGLGDVE-EAFHKIHGGKVLRSVVML----
MAV_1614|M.avium_104 RLARLYQTGQLQLDEMITKRYRLDEVN-DAYDDLLNGKIVRGIIDFGIA-
TH_2786|M.thermoresistible__bu RLLRLYRNGQLLLDEVVTAEYKLEDIT-AGYDDMLSGRNIRGVMVHQH--
Mflv_0638|M.gilvum_PYR-GCK AILDLLATGAINLGELITDEIPLDAVVSQGLEELRVNRDAHVKILIDPSA
Mvan_0527|M.vanbaalenii_PYR-1 AILDLLATGAINLGELITDEIPLDAVVSQGLEELRVNRDAHVKILIDPSA
Mb1557|M.bovis_AF2122/97 AALDLLVSGRYPFASLPRRCVRLEGAE-DLLATMAGERDGVP-PIHGVLT
Rv1530|M.tuberculosis_H37Rv AALDLLVSGRYPFASLPRRCVRLEGAE-DLLATMAGERDGVP-PIHGVLT
MAB_2041c|M.abscessus_ATCC_199 AALEILAMGRWPFDRITRESTGFAGLA-QLLTSLADESARSSGALHNVFL
MSMEG_3265|M.smegmatis_MC2_155 AAIKMIESGALPMDEICTHQFPLTEFQ-KGLDLVASGKESVKVSLIPA--
: * : . : :
MMAR_3350|M.marinum_M ---
MUL_1292|M.ulcerans_Agy99 ---
MLBr_01784|M.leprae_Br4923 ---
MAV_1614|M.avium_104 ---
TH_2786|M.thermoresistible__bu ---
Mflv_0638|M.gilvum_PYR-GCK ---
Mvan_0527|M.vanbaalenii_PYR-1 ---
Mb1557|M.bovis_AF2122/97 P--
Rv1530|M.tuberculosis_H37Rv P--
MAB_2041c|M.abscessus_ATCC_199 PTP
MSMEG_3265|M.smegmatis_MC2_155 ---