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MPAAESQQDDTAHRIRAESREFRIAAVGLLLASMIGPAQLYCIQGILPQIAQGLHISEGDSRLVFLAAFA GFAVGLIPISLLSERYGRRSILLMSSTLATLICLLLVFCHDLTEIVLLRGLQGVLLAGVSAILMAYIGEE FEPPAVTPAMGIYAAGNALGSLLGQMLPAWIVGGTGSWRLALGVLAVLLLVVVMISGMTLPRSKFFVPSA ISYIKESGLFLSHLSNRRLLVIYLLVFCFMGAIISIFNALPFRMESPPFNISPSVYGTFFLVILAGVFAA KASGAVAARIGIRITLLLSVVLMMAGVALLAIPTVWIIVIGAALVTAGAFAGYTCLTSLSAKIADRGRAQ ASALFLASSFTGSAMLGLIGSRVLTDTGWNGLLAYISGLMGLGFFLALTVRDTTSEDTE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2038 | - | - | 100% (409) | putative transport protein |
| M. abscessus ATCC 19977 | MAB_2706c | - | 4e-57 | 31.65% (376) | putative transporter |
| M. abscessus ATCC 19977 | MAB_0284c | - | 4e-16 | 23.33% (300) | major facilitator transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2361c | - | 8e-10 | 21.52% (381) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_2220 | - | 7e-14 | 22.92% (384) | Bcr/CflA subfamily drug resistance transporter |
| M. tuberculosis H37Rv | Rv2459 | - | 5e-09 | 22.96% (392) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 2e-06 | 27.22% (158) | putative transmembrane efflux protein |
| M. marinum M | MMAR_3524 | - | 2e-15 | 22.02% (377) | hypothetical protein MMAR_3524 |
| M. avium 104 | MAV_1539 | - | 4e-58 | 33.25% (388) | major facilitator family protein transporter |
| M. smegmatis MC2 155 | MSMEG_0103 | - | 1e-48 | 30.10% (382) | major facilitator family protein transporter |
| M. thermoresistible (build 8) | TH_2858 | - | 2e-08 | 29.11% (158) | PUTATIVE major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_1444 | sugI | 3e-10 | 24.82% (415) | sugar-transport integral membrane protein SugI |
| M. vanbaalenii PYR-1 | Mvan_4475 | - | 5e-12 | 26.17% (214) | Bcr/CflA subfamily drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1539|M.avium_104 ----------------MVMPN-GPVAHQAGTRG---YRRMTAALCGAG--
MSMEG_0103|M.smegmatis_MC2_155 ----------------MVTAQPEPAVWQGHTRGSSDYRRLLAALFCAG--
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
TH_2858|M.thermoresistible__bu ----------------------------------MEGANKLPTWLPSR--
Mb2361c|M.bovis_AF2122/97 -----------------------------------MNRTQLLTLIATG--
Rv2459|M.tuberculosis_H37Rv -----------------------------------MTPRQRLTVLATG--
Mflv_2220|M.gilvum_PYR-GCK ------------MSLINFMAISPDVKLKAQSPESAGPPSRTRMIIVLG--
Mvan_4475|M.vanbaalenii_PYR-1 ----------------------------------MAPPGRTRMILVLG--
MAB_2038|M.abscessus_ATCC_1997 --------------------MPAAESQQDDTAHRIRAESREFRIAAVG--
MMAR_3524|M.marinum_M ------------------------------MKASAPSRRIVAVLLCVVP-
MUL_1444|M.ulcerans_Agy99 -----------------------------------MQRGILVALTAASVG
MAV_1539|M.avium_104 ----------------LASFAAMYCTQALLPALSAHHRIGPATAALTVSL
MSMEG_0103|M.smegmatis_MC2_155 ----------------VATFAQLYSPQAVLPLIASDLGTGAAHAALAISA
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
TH_2858|M.thermoresistible__bu ---RFIAAVFAIGGMQLLATMDSTIAIVALPRIQDELNLTDAGRSWVITA
Mb2361c|M.bovis_AF2122/97 -----------LG--LFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS
Rv2459|M.tuberculosis_H37Rv -----------LG--IFMVFVDVNIVNVALPSIQKVFHTGEQGLQWAVAG
Mflv_2220|M.gilvum_PYR-GCK -------------LLVALGPLTIDMYLPALPKIGEELSVSSSVAQLTLTG
Mvan_4475|M.vanbaalenii_PYR-1 -------------LLVALGPLTIDMYLPALPKIAEELSVSSSVAQLTLTG
MAB_2038|M.abscessus_ATCC_1997 -----------LLLASMIGPAQLYCIQGILPQIAQGLHISEGDSRLVFLA
MMAR_3524|M.marinum_M -----------------LNQIPMDAYTPALPQMETSIGTTATALQSTVTV
MUL_1444|M.ulcerans_Agy99 ----------------LIYGYDLSIIAGAQLFITEEFGLSTHQQELLTTM
:
MAV_1539|M.avium_104 TTGALALSIIPASVLSERYGRTRVMLISGVASSVIGLLLPFSPSLGVLVF
MSMEG_0103|M.smegmatis_MC2_155 ATIGLAFGVLPWAALADRVGRVQVITVSVVVATVLGLLVPFAPTYALLLC
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
TH_2858|M.thermoresistible__bu YVLTFGGLMLLGGRLGDTIGRKRTFIVGVTLFTIASVLCGIAWDEATLVI
Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT
Rv2459|M.tuberculosis_H37Rv YSLGMAAVLMSCALLGDRYGRRRSFVFGVTLFVVSSIVCVLPVSLAVFTV
Mflv_2220|M.gilvum_PYR-GCK TLAGLAIGQLVIGPLSDSLGRRKPLFAGIVLHMVASLLCMFAPTITVLGI
Mvan_4475|M.vanbaalenii_PYR-1 TLAGLAIGQLVIGPLSDSLGRRRPLFAGIVLHMLASLLCLLAPNITVLGV
MAB_2038|M.abscessus_ATCC_1997 AFAGFAVGLIPISLLSERYGRRSILLMSSTLATLICLLLVFCHDLTEIVL
MMAR_3524|M.marinum_M FMIGMALSYLAVGIMSDSWGRKPVLMGCAAALTVTSLACAAANNVAMLLV
MUL_1444|M.ulcerans_Agy99 VVIGQIVGALGAGVLANAIGRKKSVVMLLVAYTMFAVLGALSVSLPMLLA
: . :.: ** : : :
MAV_1539|M.avium_104 GRAVQGVALAGIPAVAMALLAEEVDAS-SLGSAMGRYIAGTTIGGLAGRI
MSMEG_0103|M.smegmatis_MC2_155 GRFVEGLALAGVPAVAVAYLTEEINAG-HAARAAGTYVAGTTIGGLAGRL
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
TH_2858|M.thermoresistible__bu ARLLQGVGAAIASPTGLALVATTFPKGPARNAATAVFAAMTGVGSVMGLV
Mb2361c|M.bovis_AF2122/97 ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT
Rv2459|M.tuberculosis_H37Rv ARVIQGLGAAFISVLSLALLSHSFPNPRMKARAISNWMAIGMVGAASAPA
Mflv_2220|M.gilvum_PYR-GCK ARGLQGMGAAAGMVVAIAVVGDLYKDN-AAATVMSRLMLVLGVAPVLAPS
Mvan_4475|M.vanbaalenii_PYR-1 ARCLQGMGAAAGMVVAIAVVGDLYKDN-VAATVMSRLMLVLGVAPVLAPS
MAB_2038|M.abscessus_ATCC_1997 LRGLQGVLLAGVSAILMAYIGEEFEPP-AVTPAMGIYAAGNALGSLLGQM
MMAR_3524|M.marinum_M LRFLQGGACSAFIVVAIAIAADCFEGA-RLRSVNGLLGAAWSAAPILAPA
MUL_1444|M.ulcerans_Agy99 ARFLLGLAVGVSIVVVPVYVAESAPAA-VRGSLLTVYQLTTVSGLIVG-Y
* * . . . .
MAV_1539|M.avium_104 VPSVVV-QVGTWRVALLACSLITLAGTAVFAVLVPRSRFFT---------
MSMEG_0103|M.smegmatis_MC2_155 VTGPVA-EFAGWRVGVLTVALLCGMAALAFVKLAPAAQGFT---------
MLBr_01562|M.leprae_Br4923 VGGALT-EVS-WRLAFLVNVPIGLVMIYLARTALHETHKER-MKLDAAGA
TH_2858|M.thermoresistible__bu VGGALT-EVS-WRLAFLVNVPIGLLVIYLARRTLRETHRER-LKLDAAGA
Mb2361c|M.bovis_AF2122/97 LGGLLV-DQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQ
Rv2459|M.tuberculosis_H37Rv LGGLMV-DGLGWRSVFLVNVPLGAIVWLLTLVGVDESQDPEPTQLDWVGQ
Mflv_2220|M.gilvum_PYR-GCK LGAAVL-LHGSWHWVFAALVVVAAALLVMAVLALPETLPVD---------
Mvan_4475|M.vanbaalenii_PYR-1 FGAAVL-LHGSWHWVFAALVVVAGALLVMSVLALPETLPAD---------
MAB_2038|M.abscessus_ATCC_1997 LPAWIVGGTGSWRLALGVLAVLLLVVVMISGMTLPRSKFFV---------
MMAR_3524|M.marinum_M VGGFIV-EYASWRYVFVLIAALSVVVGLAVTWALPETLDQE---------
MUL_1444|M.ulcerans_Agy99 LTGYLLAGTHSWRWMLGLATVPAMLLLPLLIRMPDTPRWYVMKG------
. . : *: . .
MAV_1539|M.avium_104 ------------------------------------------PKPASVRA
MSMEG_0103|M.smegmatis_MC2_155 ------------------------------------------PARTHWDL
MLBr_01562|M.leprae_Br4923 ILATLACTAAVFAFSMGPEKGWISLTTIGSG-LVALVAAIAFAVVERTAE
TH_2858|M.thermoresistible__bu ILATLGCTAAVFAFSMGPERGWASVITIATG-AAALVFLLAFLYVERTAD
Mb2361c|M.bovis_AF2122/97 LLFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAA-VGCALFVWLERRSS
Rv2459|M.tuberculosis_H37Rv LTLIPAVALIAYTIIEAPRFDRQSAGFVAALLLAAGVLLWLFVRHEHRAA
Mflv_2220|M.gilvum_PYR-GCK -----------------------------------------HRRPLKVRG
Mvan_4475|M.vanbaalenii_PYR-1 -----------------------------------------HRRPLKARG
MAB_2038|M.abscessus_ATCC_1997 ------------------------------------------PSAISYIK
MMAR_3524|M.marinum_M -----------------------------------------SRTRFELGQ
MUL_1444|M.ulcerans_Agy99 ---------------RIQEARAALLRVDPAADVEEELAEIGTALSEGSGG
MAV_1539|M.avium_104 ALRNLAGHLRNPVLAKLFAVGFVLMGGFVTVYNYLGYRLAARPFGLAPSV
MSMEG_0103|M.smegmatis_MC2_155 GRR-LLTNLRSPRQLALFAQGFLLMGGFVAVYNFLGFRLSAAPFNLPQTV
MLBr_01562|M.leprae_Br4923 NPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQD-ILGYSALR
TH_2858|M.thermoresistible__bu NPVVPFSLFRDRNRVATFGAIFLAGGVMFTLTVLIGLYVQD-IMGYSPLR
Mb2361c|M.bovis_AF2122/97 NPMMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQN-VRGYTPSV
Rv2459|M.tuberculosis_H37Rv FPLVDLKLFAEPLYRSVLIVYFVVMSCFFGTLMVITQHFQN-VRDLSPLH
Mflv_2220|M.gilvum_PYR-GCK IAATYLELVRDARFVILVLVAALGMSGLFAYIAGASFVLQG-RFGLDQTA
Mvan_4475|M.vanbaalenii_PYR-1 IALTYLELLRDVRFVILVFVGALGMSGLFAYIAGASFVLQG-RFGLDQTA
MAB_2038|M.abscessus_ATCC_1997 ESGLFLSHLSNRRLLVIYLLVFCFMGAIISIFNALPFRMESPPFNISPSV
MMAR_3524|M.marinum_M TWQVLTATARNRVFLALAAIFGLLAGPQLSFGVAAPFLYQD-EMGFSPSA
MUL_1444|M.ulcerans_Agy99 VSEMLRPPFLRATIFVITLGFLIQITGINAIIYYSPRIFEAMGFTGDFAL
MAV_1539|M.avium_104 VGLLFLLYLVGTGTS-VVAGRLADRRGRPLVLGAALPIAVAGLLLTVPPS
MSMEG_0103|M.smegmatis_MC2_155 VSLVFLAYLAGTWAS-ARAGAEATRFGRKPVLLVSIATMIAGVAVTMSTN
MLBr_01562|M.leprae_Br4923 AGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFM
TH_2858|M.thermoresistible__bu AGIGFIPFVIALGIGLAASSQLVRLFPPRVLVFGGGVLVLGAMLYG-STL
Mb2361c|M.bovis_AF2122/97 TGLMILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSE
Rv2459|M.tuberculosis_H37Rv AGLMMLPVPAGFGVASLLAGRAVNKWGPQLPVLTCLAAMFIGLAIFAISM
Mflv_2220|M.gilvum_PYR-GCK FALVFGAGAVALIGTTQCNVILLKRFTPQQIMVWALAASSVFGLVFVALA
Mvan_4475|M.vanbaalenii_PYR-1 FALVFGAGAIALIGTTQFNVVLLKRFAPQQIMVWALVAASLSGAVFVALA
MAB_2038|M.abscessus_ATCC_1997 YGTFFLVILAGVFAA-KASGAVAARIGIRITLLLSVVLMMAGVALLAIPT
MMAR_3524|M.marinum_M YGLIALVVGVAVLLGSFSTGMLATRMAFRRLAFADWTLYMVGAALLLGSA
MUL_1444|M.ulcerans_Agy99 LGLPALVQIAG-VAAVITSLLLVDRVGRRPILLSGIAIMIVADVALMAVF
. .
MAV_1539|M.avium_104 LAAI------VAGVGVFTGGF-FAAHTV-ASGWVGAVAQRDRAEASALYL
MSMEG_0103|M.smegmatis_MC2_155 AVVV------LVGLVIATAGF-FGAHAI-ASGWVGAEAGDSKAQASALYN
MLBr_01562|M.leprae_Br4923 NRGVPYFPNLLAPIVVGGIGIGMAVVPL-TLSAIAGVGFDRIGPVSAIAL
TH_2858|M.thermoresistible__bu HADIPYFPNLVVPIVVGGIGIGVIVVPL-TVSAIAGVGFDQIGPVSAIAL
Mb2361c|M.bovis_AF2122/97 HRSS---ALVLVGLGLCGSGVALCLTPI-TTVAMTAVPAERAGMASGIMS
Rv2459|M.tuberculosis_H37Rv DHAH---PVALVGLTIFGAGAGGCATPL-LHLGMTKVDDGRAGMAAGMLN
Mflv_2220|M.gilvum_PYR-GCK AAGVGGVFGFVIPVWAILAAMGLVIPNA-PAVALTRHP-DAAGTAAALLG
Mvan_4475|M.vanbaalenii_PYR-1 AAHIGGLWGFVIPVWAILAAMGLVIPNA-PAVALTRHP-DAAGTAAALLG
MAB_2038|M.abscessus_ATCC_1997 VWII------VIGAALVTAGA-FAGYTC-LTSLSAKIADRGRAQASALFL
MMAR_3524|M.marinum_M PVVGVNPWAITLAVSLAVAGCGALVPQA-QAAALGAFS-RNLGLVSGLFG
MUL_1444|M.ulcerans_Agy99 ARGQGAAILGFAGILLFIIGYTMGFGSLGWVYASESFPTRLRSIGSSTML
. . :.
MAV_1539|M.avium_104 FSYYLGGSVAGAFGGVLYGVGG----------------------------
MSMEG_0103|M.smegmatis_MC2_155 LFYYGGSSAVGWLGGLAFDAAG----------------------------
MLBr_01562|M.leprae_Br4923 MLQSLGGPLVLAVIQAVITSRT------LYLGGTTGPVK-------FMND
TH_2858|M.thermoresistible__bu MLQNLGGPLVLAVVQAVITSRT------LYLGGTTGPVQ-------NMDT
Mb2361c|M.bovis_AF2122/97 AQRAIGSTIGFAVLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEIIIDS
Rv2459|M.tuberculosis_H37Rv LQRSLGGIFGVAFLGTIVAAWLGAALPNTMADEIPDPIARAIVVDVIVDS
Mflv_2220|M.gilvum_PYR-GCK AVQFGGGAAIAPVVGVLG--------------------------------
Mvan_4475|M.vanbaalenii_PYR-1 AVQFGMGAAIAPVVGVLG--------------------------------
MAB_2038|M.abscessus_ATCC_1997 ASSFTGSAMLGLIGSRVLTDTG----------------------------
MMAR_3524|M.marinum_M TLTYLIIAAIMAIVGVSPERTQ----------------------------
MUL_1444|M.ulcerans_Agy99 TANLIANAIVAAVFLTMLHSLG----------------------------
.
MAV_1539|M.avium_104 ---------------WSATVCFVVVLLMAGAALVALLVRDNGFRIGRRVV
MSMEG_0103|M.smegmatis_MC2_155 ---------------WSA----VAGTVMGLAALAGLIA----FALAR---
MLBr_01562|M.leprae_Br4923 AQLRALDHGYTYGLLWVAG---AVVIVGVAALFIGYTPEQVAYAQEVKEA
TH_2858|M.thermoresistible__bu AQLHALDQGYTYGLLWVAA---VAVLVGGAALFIGYTAKQVAHAQEVKDA
Mb2361c|M.bovis_AF2122/97 ANPRAHVGGIVPRRHIEHR---DPVAIAEEDFIEGIRVALLVATATLAVV
Rv2459|M.tuberculosis_H37Rv ANPHAHAAFIGPGHRITAAQEDEIVLAADAVFVSGIKLALGGAAVLLTGA
Mflv_2220|M.gilvum_PYR-GCK ------NDELAMAVVMAAG----VIIALGALLVTGAHRNTEPARVPDEAV
Mvan_4475|M.vanbaalenii_PYR-1 ------NDELAMAVVMAAG----VIVALTALLVTGVHRNTAPAAVPGEAV
MAB_2038|M.abscessus_ATCC_1997 -------------------------WNGLLAYISGLMGLGFFLALTVRDT
MMAR_3524|M.marinum_M ------------------------APLGWLYVLCGALVFAALAWVTPRVQ
MUL_1444|M.ulcerans_Agy99 --------------GSGAFAVFGVLALVAFGVVYRYAPETKGRQLEEIRH
.
MAV_1539|M.avium_104 AGVASVK--------------------------
MSMEG_0103|M.smegmatis_MC2_155 ---------------------------------
MLBr_01562|M.leprae_Br4923 VDAGEL---------------------------
TH_2858|M.thermoresistible__bu IDAGEL---------------------------
Mb2361c|M.bovis_AF2122/97 FLAGWRWFPRDVQTAGSDAKREAAYSDDRRVRG
Rv2459|M.tuberculosis_H37Rv FVLGWTRFPRTPAS-------------------
Mflv_2220|M.gilvum_PYR-GCK AEPA-----------------------------
Mvan_4475|M.vanbaalenii_PYR-1 AEPA-----------------------------
MAB_2038|M.abscessus_ATCC_1997 TSEDTE---------------------------
MMAR_3524|M.marinum_M GEKPTPG--------------------------
MUL_1444|M.ulcerans_Agy99 FWENGGRWPEKLTEAP-----------------