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MTPRQRLTVLATGLGIFMVFVDVNIVNVALPSIQKVFHTGEQGLQWAVAGYSLGMAAVLMSCALLGDRYG RRRSFVFGVTLFVVSSIVCVLPVSLAVFTVARVIQGLGAAFISVLSLALLSHSFPNPRMKARAISNWMAI GMVGAASAPALGGLMVDGLGWRSVFLVNVPLGAIVWLLTLVGVDESQDPEPTQLDWVGQLTLIPAVALIA YTIIEAPRFDRQSAGFVAALLLAAGVLLWLFVRHEHRAAFPLVDLKLFAEPLYRSVLIVYFVVMSCFFGT LMVITQHFQNVRDLSPLHAGLMMLPVPAGFGVASLLAGRAVNKWGPQLPVLTCLAAMFIGLAIFAISMDH AHPVALVGLTIFGAGAGGCATPLLHLGMTKVDDGRAGMAAGMLNLQRSLGGIFGVAFLGTIVAAWLGAAL PNTMADEIPDPIARAIVVDVIVDSANPHAHAAFIGPGHRITAAQEDEIVLAADAVFVSGIKLALGGAAVL LTGAFVLGWTRFPRTPAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2459 | - | - | 100% (508) | PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN |
| M. tuberculosis H37Rv | Rv2333c | - | e-113 | 44.05% (504) | integral membrane transport protein |
| M. tuberculosis H37Rv | Rv0783c | emrB | 2e-42 | 25.31% (403) | multidrug resistance integral membrane efflux protein EmrB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2486 | - | 0.0 | 99.80% (508) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1730 | - | 5e-54 | 30.94% (417) | EmrB/QacA family drug resistance transporter |
| M. leprae Br4923 | MLBr_01562 | - | 1e-35 | 24.76% (416) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_0945 | - | 2e-57 | 29.71% (414) | EmrB/QacA family drug resistance transporter |
| M. marinum M | MMAR_3806 | - | 0.0 | 77.98% (504) | integral membrane transport protein |
| M. avium 104 | MAV_0729 | - | 5e-48 | 28.43% (408) | EmrB efflux protein |
| M. smegmatis MC2 155 | MSMEG_5670 | - | 9e-52 | 28.50% (428) | efflux membrane protein |
| M. thermoresistible (build 8) | TH_3412 | - | 1e-43 | 27.66% (488) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_3729 | - | 0.0 | 77.29% (502) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_5021 | - | 2e-55 | 30.54% (429) | EmrB/QacA family drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------M
MSMEG_5670|M.smegmatis_MC2_155 ------------------------------------------MNETVGAL
MAB_0945|M.abscessus_ATCC_1997 ------------------------------------------MEAAVGAL
Rv2459|M.tuberculosis_H37Rv --------------------------------------------------
Mb2486|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3806|M.marinum_M --------------------------------------------------
MUL_3729|M.ulcerans_Agy99 --------------------MSNPGEIGEPPTTSGSAEVPATAPATDNVV
MAV_0729|M.avium_104 ----------------MLSGAMEKTRSAAFSVPLATASGPSLRDDEYPDK
TH_3412|M.thermoresistible__bu -------------------------------------------MTQCAVR
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
Mflv_1730|M.gilvum_PYR-GCK TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRADLSASPAQMQWVVDI
Mvan_5021|M.vanbaalenii_PYR-1 TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRDDLSATPAQMQWVVDV
MSMEG_5670|M.smegmatis_MC2_155 SARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRSDLGASPSQLQWVIDV
MAB_0945|M.abscessus_ATCC_1997 SERRKIVILGSCCLSLLIVSMDSTIVNVALPTIRADFGATTSQLQWVIDI
Rv2459|M.tuberculosis_H37Rv MTPRQRLTVLATGLGIFMVFVDVNIVNVALPSIQKVFHTGEQGLQWAVAG
Mb2486|M.bovis_AF2122/97 MTPRQRLTVLATGLGIFMVFVDVNIVNVALPSIQKVFHTGEQGLQWAVAG
MMAR_3806|M.marinum_M MTRRQRLTVAATGLGIFMVFVDVNIVNVALPSIQRVFHTGEQGLQWAVAG
MUL_3729|M.ulcerans_Agy99 MTRRQRLTVAATGLGIFMVFVDVNIVNVALPSIQRVFHTGEQGLQWAVAG
MAV_0729|M.avium_104 LDAALFRIAGVCGLACIMAVLDSTVVAVAQRTFIAQFGANQAIVSWTIAG
TH_3412|M.thermoresistible__bu AGAREWAGLGVLAVPTVLLGLDVTVLYLVLPAVAADLAPSPVQTLWIMDA
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
.: :* .: :. . : * :
Mflv_1730|M.gilvum_PYR-GCK YTLVLASLLMLSGATGDRFGRRRLFQIGLTVFALGSLACSLAPTIDTLIG
Mvan_5021|M.vanbaalenii_PYR-1 YTLVLASLLMLSGATGDRFGRRRVFQIGLAVFALGSLACSLAPTIDALIG
MSMEG_5670|M.smegmatis_MC2_155 YTLVLASLLLLAGATGDRFGRRRTFHLGLTVFAVASLLCSVAPNIETLIA
MAB_0945|M.abscessus_ATCC_1997 YTLGLASLLMLSGAAGDRLGRRKVFHLGLSIFAIGSLLCSVAPTVGLLIA
Rv2459|M.tuberculosis_H37Rv YSLGMAAVLMSCALLGDRYGRRRSFVFGVTLFVVSSIVCVLPVSLAVFTV
Mb2486|M.bovis_AF2122/97 YSLGIAAVLMSCALLGDRYGRRRSFVFGVTLFVVSSIVCVLPVSLAVFTV
MMAR_3806|M.marinum_M YSLGMAAMLMSCALLGDRYGRRRGFFVGLALFVASSVVCVLPINLGMFTA
MUL_3729|M.ulcerans_Agy99 YSLGMAAMLMSCALLGDRYGRRRGFFVGLALFVASSVVCVLPINLGMFTA
MAV_0729|M.avium_104 YMLAFATVIPITGWAADRFGTKRLFMGSVLIFTLGSLLCAVAPNILLLIL
TH_3412|M.thermoresistible__bu YGFFIAGFLITMGTLGDRIGRRRLLTIGVTAFAGASVLAALAPSAELLIV
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
* : :. .: . .* * :: : .: *. .*: . :. :
Mflv_1730|M.gilvum_PYR-GCK ARFLQGVGGSMLNPVALSIISQIFTKPVERARALGIWGGVTGISMAAGPI
Mvan_5021|M.vanbaalenii_PYR-1 ARLLQGIGGSMLNPVALSIISQIFTQPVERARALGIWGGVTGISMAAGPI
MSMEG_5670|M.smegmatis_MC2_155 ARLLQAIGGSMLNPVAMSIITQVFTGRVERARAIGVWGSVVGISMALGPL
MAB_0945|M.abscessus_ATCC_1997 ARLLQAVGGSMLNPVALSIISQVFTGRVERARALGFWGAVVGISMALGPI
Rv2459|M.tuberculosis_H37Rv ARVIQGLGAAFISVLSLALLSHSFPNPRMKARAISNWMAIGMVGAASAPA
Mb2486|M.bovis_AF2122/97 ARVIQGLGAAFISVLSLALLSHSFPNPRMKARAISNWMAIGMVGAASAPA
MMAR_3806|M.marinum_M ARVIQGLGASFISVLSLALLSHAFPDQRMKARAIADWMAIGMVGAASAPA
MUL_3729|M.ulcerans_Agy99 ARVIQGLDASFISVLSLALLSHAFPDQRMKARAIADWMAIGMVGAASAPA
MAV_0729|M.avium_104 FRVVQGVGGGMLLPLSFVILTREAG-PKRVGRLMAVGGIPILLGPIGGPI
TH_3412|M.thermoresistible__bu ARALLGVAGATLMPSTLSLISNMFVDAAQRALAIGVWATMFAVGMAAGPV
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
* : .: .. : ::: . :. .
Mflv_1730|M.gilvum_PYR-GCK VGGLLIETVGWRSVFWINLPICAAAIILTAVFVPESKSQTMRNVDPIGQG
Mvan_5021|M.vanbaalenii_PYR-1 VGGLLIDTIGWRSVFWINLPICAAAILLTAIFVPESKSQTMRNVDPIGQG
MSMEG_5670|M.smegmatis_MC2_155 VGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKSSTMRDVDPVGQG
MAB_0945|M.abscessus_ATCC_1997 VGGLLIQWVGWRAVFWINLPVCVLAFVLTAVFVPETKSATMRDIDPVGQA
Rv2459|M.tuberculosis_H37Rv LGGLMVDGLGWRSVFLVNVPLGAIVWLLTLVGVDESQDPEPTQLDWVGQL
Mb2486|M.bovis_AF2122/97 LGGLMVDGLGWRSVFLVNVPLGAIVWLLTLVGVDESQDPEPTQLDWVGQL
MMAR_3806|M.marinum_M LGGLMVETLGWRSVFAVNVPLGAIVLVLTLIGVDESRDPDPTELDWVGQL
MUL_3729|M.ulcerans_Agy99 LGGLMVETLGWRSVFAVSVPLGAIVLVLTLIGVDESRDPDPTELDWVGQL
MAV_0729|M.avium_104 LGGWLIGAYGWKWIFLINLPIGLTAFALAALLFPKDRSAPSEALDITGAL
TH_3412|M.thermoresistible__bu VGGALVDRFWWGAAFLLAVPV-AAAVLLGARLLPEYADPQAGRLDLRSVA
MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKER-MKLDAAGAI
:** : * * : :*: * . : . :* .
Mflv_1730|M.gilvum_PYR-GCK LGILFLFGTVFTLIEGPVLG-WTNPRVLAIAAVAVVALIAFLRFES-RRH
Mvan_5021|M.vanbaalenii_PYR-1 LAIMFLFGTVFTLIEGPVLG-WTNPRVVVAAVVVALALVAFLRFES-RRH
MSMEG_5670|M.smegmatis_MC2_155 LGVAFLFGVVFVLIEGPGMG-WTDPRTLAVAATALVAFLAFLRYES-RRH
MAB_0945|M.abscessus_ATCC_1997 LAVLFLFGIVFALIEGPSLG-WATPGLIVVLAVALAAFAVFLRYES-RRR
Rv2459|M.tuberculosis_H37Rv TLIPAVALIAYTIIEAPRFDRQSAGFVAALLLAAGVLLWLFVRHEH-RAA
Mb2486|M.bovis_AF2122/97 TLIPAVALIAYTIIEAPRFDRQSAGFVAALLLAAGVLLWLFVRHEH-RAA
MMAR_3806|M.marinum_M TFVPGIAVLAYTIIEAPRFQQRSVIVLTSLLLIIVALLWTFIRHER-RAP
MUL_3729|M.ulcerans_Agy99 TFVPGIAVLAYTIIEAPRFQQRSVIVLTSLLLIIVALLRTFIRHER-RAP
MAV_0729|M.avium_104 LLSPGVAIFLCGVCSIPGRHTVADRYVLVPALVGLVLIAAFILHAWYRTE
TH_3412|M.thermoresistible__bu LSLLAILAAIYAVKHVAVHG--VDGVAVAACALAAAAATVFVHRQR-RLD
MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEKG-WISLTTIGSGLVALVAAIAFAVVER-TAE
. . *
Mflv_1730|M.gilvum_PYR-GCK DPFLDLRFFRSIPFTTATINAISAFAAWGAFLFMMSLYLQGERGFSAMQT
Mvan_5021|M.vanbaalenii_PYR-1 DPFLDLRFFRSIPFTTATVIAISAFAAWGAFLFLMSLYLQGERGFSAMHT
MSMEG_5670|M.smegmatis_MC2_155 DPFIDLRFFRSVPFASATLVAVCAFAAYGAFLFMMSLYLQSERGYSAMFT
MAB_0945|M.abscessus_ATCC_1997 HPFIDLRFFRSIPFASATLTAICACMAWSAFLFTMSLYLQGQRHFSAMHT
Rv2459|M.tuberculosis_H37Rv FPLVDLKLFAEPLYRSVLIVYFVVMSCFFGTLMVITQHFQNVRDLSPLHA
Mb2486|M.bovis_AF2122/97 FPLVDLKLFAEPLYRSVLIVYFVVMSCFFGTLMVITQHFQNVRDLSPLHA
MMAR_3806|M.marinum_M FPLIDLQLFTEPVYRSVLIVYFVVMSCFFGTLMVITQFFQNVRDLSPLHA
MUL_3729|M.ulcerans_Agy99 FPLIDLQLFTEPVYRSVLIVYFVVMSCFFGTLMVITQFFQNVRDLSPLHA
MAV_0729|M.avium_104 HPLIDLRLFRNPVVTQVNVTLLVFAAASVGVGLLVPSYFQIVGHETPMQS
TH_3412|M.thermoresistible__bu APLLDVTLFADRAFTAALTVLLIGLIGVGGTMYLVTQFLQLVEGLTPVRA
MLBr_01562|M.leprae_Br4923 NPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRA
*.: . :* . . . . : .:* :.: :
Mflv_1730|M.gilvum_PYR-GCK GLIYLPIALGALFCSPLSGRLVGRYGARPSLVAAGILITTAATLLTLLTA
Mvan_5021|M.vanbaalenii_PYR-1 GLIYLPIAIGALLFSPLSGRLVGRYGARPSLVIAGVTITAAATMLTFLTA
MSMEG_5670|M.smegmatis_MC2_155 GLIYLPIAIGALIFSPLSGRMVGRFGSRPSLVSAGVLITAATVMLAQMTA
MAB_0945|M.abscessus_ATCC_1997 GLIYLPIAVGALVFSPISGRMVGRFGARPSLLAAGTLFLTASLLLTRVSE
Rv2459|M.tuberculosis_H37Rv GLMMLPVPAGFGVASLLAGRAVNKWGPQLPVLTCLAAMFIGLAIFAISMD
Mb2486|M.bovis_AF2122/97 GLMMLPVPAGFGVASLLAGRAVNKWGPQLPVLTCLAAMFIGLAIFAISMD
MMAR_3806|M.marinum_M GLMMLPVPAGFGMASLLAGAAVNKWGPRLPVVTCLAAMVTGLVLFVTAMG
MUL_3729|M.ulcerans_Agy99 GLMMLPVPAGFGMASLLAGAAVNKWGPRLPVVTCLAAMVTGLVLFVTAMG
MAV_0729|M.avium_104 GLHMLPIGVGAVLTMPLGGAVMDKHGPGKIVLTGLPLMAVGLAVFTYGVA
TH_3412|M.thermoresistible__bu GWWMGPPALAMFVAAIGAPLIARRVRPGVVMAATLGVSVLGYAVLASAGR
MLBr_01562|M.leprae_Br4923 GIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMN
* * . . . : . .
Mflv_1730|M.gilvum_PYR-GCK TTPVWH--LLIVFAVFGVGFSMVNAPITNAAVSGMPLDRAGAASAVTSTS
Mvan_5021|M.vanbaalenii_PYR-1 TTPVWS--LLMVFAVFGIGFSMVNAPVTNAAVSGMPLDRAGAASAVTSTS
MSMEG_5670|M.smegmatis_MC2_155 TTPVWL--LLVIFAVFGIGFALVNAPITTAAVSGMPLDRAGAASAVASTS
MAB_0945|M.abscessus_ATCC_1997 ATPIWE--LLVTFAIFGAGFAMVNAPITNAAVSGMPLDRAGAASAVTSTS
Rv2459|M.tuberculosis_H37Rv HAHPVA--LVG-LTIFGAGAGGCATPLLHLGMTKVDDGRAGMAAGMLNLQ
Mb2486|M.bovis_AF2122/97 HAHPVA--LVG-LTIFGAGAGGCATPLLHLGMTKVDDGRAGMAAGMLNLQ
MMAR_3806|M.marinum_M HVPALA--LMG-LTVFGAGAGGSVTPLLHLGMTKVDDHRAGMAAGLLNLQ
MUL_3729|M.ulcerans_Agy99 HVPALA--LMG-LTVFGAGAGGSVTPLLHLGMTKVDDHRAGMAAGLLNLQ
MAV_0729|M.avium_104 RQAAYSPVLVCGLAIMGLGIGLTTTPLSAALMQALAPHQVARGTTLISVN
TH_3412|M.thermoresistible__bu GDGPAV---VVAFAFVYLGLGAIAALGTDIVVGAAPAAKSGSAAAMSETV
MLBr_01562|M.leprae_Br4923 RGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALML
: :.. * . . : : . : :
Mflv_1730|M.gilvum_PYR-GCK RQVGVSIGVALCGSVAGAAMAGSGTDFATAARPLWFVCIALGLVILAVGF
Mvan_5021|M.vanbaalenii_PYR-1 RQVGVSIGVALCGSLAGSAMATGGADFAAAARPLWFVCMALGLVILGLGL
MSMEG_5670|M.smegmatis_MC2_155 RQVGVSIGVALCGSVAGTALAGTGVDFAAASRPLWLICTALGVVIVAIGI
MAB_0945|M.abscessus_ATCC_1997 RQVGVSIGVALCGSIG--------------TPALWFMCAGLGLLIATLGI
Rv2459|M.tuberculosis_H37Rv RSLGGIFGVAFLGTIVAAWLGAALPNTMADEIPDPIARAIVVDVIVDSAN
Mb2486|M.bovis_AF2122/97 RSLGGIFGVAFLGTIVAAWLGAALPNTMADEIPDPIARAIVVDVIVDSAN
MMAR_3806|M.marinum_M RSMGGIFGVAFLGSILAAWLGATLPDSMEDDLPDPVVRSIVVDTIVDSAN
MUL_3729|M.ulcerans_Agy99 RSMGGIFGVAFLGSILAAWLGATLPDSMEDDLPDPVVRSIVVDTIVDSAN
MAV_0729|M.avium_104 QQVGGSIGAALMAVILTNQFNRNPALMAANEAAGMHPVTGKRGLPVDPST
TH_3412|M.thermoresistible__bu QELGIAVGVALLGSVTAAVYRSRMTGPEGVAEGVGGPDAERLAESLPAAV
MLBr_01562|M.leprae_Br4923 QSLGGPLVLAVIQAVITSR-----TLYLGGTTGPVKFMNDAQLRALDHGY
:.:* . *. : .
Mflv_1730|M.gilvum_PYR-GCK FSTSQRAVRSAERLAPLVAGAPDPVNGAHVR-------------------
Mvan_5021|M.vanbaalenii_PYR-1 FATSQRALRSAERLAPLVSGAPEPVGGAHVR-------------------
MSMEG_5670|M.smegmatis_MC2_155 VSTSPWALRSAERLAPLIGQHHRPAEVAHAR-------------------
MAB_0945|M.abscessus_ATCC_1997 VSTSPAAVRSAQRLAPLIEGT-TAREMSRVG-------------------
Rv2459|M.tuberculosis_H37Rv PHAHAAFIGPGHRITAAQEDEIVLAADAVFVSGIKLALGGAAVLLTGAFV
Mb2486|M.bovis_AF2122/97 PHAHAAFIGPGHRITAAQEDEIVLAADAVFVSGIKLALGGAAVLLTGAFV
MMAR_3806|M.marinum_M PHAHAAFIGPRHRITSAQETNIVSAADSDFMQGIRIALGCASVLLAAAFV
MUL_3729|M.ulcerans_Agy99 PHAHAAFIGPRHRITSAQETNIVSAADSDFMQGIRIALGCASVLLAAAFV
MAV_0729|M.avium_104 VPRPAMTPELAGHVSHHLSHAYTAVFVLAVVLVACTIIPASFLPRKPPSP
TH_3412|M.thermoresistible__bu SVADRVPGEAVRLAQDAFAAGVNIAALIGGAAVVVVAVVCATALRHLRPL
MLBr_01562|M.leprae_Br4923 TYGLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL-------
Mflv_1730|M.gilvum_PYR-GCK ----------------------------
Mvan_5021|M.vanbaalenii_PYR-1 ----------------------------
MSMEG_5670|M.smegmatis_MC2_155 ----------------------------
MAB_0945|M.abscessus_ATCC_1997 ----------------------------
Rv2459|M.tuberculosis_H37Rv LGWTRFPRTPAS----------------
Mb2486|M.bovis_AF2122/97 LGWTRFPRTPAS----------------
MMAR_3806|M.marinum_M LGLRRFPRPDSDESPDPDESQLAGSDLD
MUL_3729|M.ulcerans_Agy99 LGFRRFACPDSDESPDPDESQLAGSDLD
MAV_0729|M.avium_104 PAGD------------------------
TH_3412|M.thermoresistible__bu D---------------------------
MLBr_01562|M.leprae_Br4923 ----------------------------