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VKASAPSRRIVAVLLCVVPLNQIPMDAYTPALPQMETSIGTTATALQSTVTVFMIGMALSYLAVGIMSDS WGRKPVLMGCAAALTVTSLACAAANNVAMLLVLRFLQGGACSAFIVVAIAIAADCFEGARLRSVNGLLGA AWSAAPILAPAVGGFIVEYASWRYVFVLIAALSVVVGLAVTWALPETLDQESRTRFELGQTWQVLTATAR NRVFLALAAIFGLLAGPQLSFGVAAPFLYQDEMGFSPSAYGLIALVVGVAVLLGSFSTGMLATRMAFRRL AFADWTLYMVGAALLLGSAPVVGVNPWAITLAVSLAVAGCGALVPQAQAAALGAFSRNLGLVSGLFGTLT YLIIAAIMAIVGVSPERTQAPLGWLYVLCGALVFAALAWVTPRVQGEKPTPG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_3524 | - | - | 100% (402) | hypothetical protein MMAR_3524 |
M. marinum M | MMAR_3642 | - | 9e-18 | 22.84% (359) | integral membrane transport protein |
M. marinum M | MMAR_1306 | - | 1e-17 | 28.17% (355) | transmembrane transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1908 | - | 1e-17 | 27.00% (237) | hypothetical protein Mb1908 |
M. gilvum PYR-GCK | Mflv_2220 | - | 7e-34 | 27.87% (366) | Bcr/CflA subfamily drug resistance transporter |
M. tuberculosis H37Rv | Rv1877 | - | 7e-18 | 26.10% (318) | integral membrane protein |
M. leprae Br4923 | MLBr_01562 | - | 1e-14 | 23.26% (417) | putative transmembrane efflux protein |
M. abscessus ATCC 19977 | MAB_1395 | - | 2e-35 | 28.21% (390) | Bcr/CflA family multidrug resistance transporter |
M. avium 104 | MAV_2832 | - | 4e-17 | 24.54% (379) | drug transporter |
M. smegmatis MC2 155 | MSMEG_2991 | - | 1e-44 | 31.28% (390) | permease of the major facilitator superfamily protein |
M. thermoresistible (build 8) | TH_2729 | - | 8e-17 | 22.78% (360) | PUTATIVE putative drug resistance transporter, EmrB/QacA |
M. ulcerans Agy99 | MUL_2115 | efpA | 3e-15 | 22.99% (422) | integral membrane efflux protein EfpA |
M. vanbaalenii PYR-1 | Mvan_4475 | - | 8e-34 | 29.17% (360) | Bcr/CflA subfamily drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment Rv1877|M.tuberculosis_H37Rv ------------------------MAGPTAPTTAPTAIRAGGPLLSPVRR MAV_2832|M.avium_104 ------------------------MNAPARADTG-----SGGERISPQRR Mb1908|M.bovis_AF2122/97 ------------------------MAGPTAPTTAPTAIRAGGPLLSPVRR MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSK-YPTLLPSGR MUL_2115|M.ulcerans_Agy99 MTALNDTERAVHNWTSGRQERPTSARATRETETASERASRYYPTWLPSR- Mflv_2220|M.gilvum_PYR-GCK --------------MSLINFMAISPDVKLKAQSPE-------SAGPPS-- Mvan_4475|M.vanbaalenii_PYR-1 -------------------------------------------MAPPG-- MAB_1395|M.abscessus_ATCC_1997 --------------MRALSTEVTSAPGKTTVDDPATDRTPAGSVSPPATR MSMEG_2991|M.smegmatis_MC2_155 --------------MRIR-------------------------TAAPGTT TH_2729|M.thermoresistible__bu -------------------------------------------------- MMAR_3524|M.marinum_M -----------------------------------------MKASAPSRR Rv1877|M.tuberculosis_H37Rv ----NIIFTALVFG--VLVAATGQTIVVPALPTIVAELG-STVDQSWAVT MAV_2832|M.avium_104 ----NLIFVAIVLG--MLLAALDQTIVATALPTIVANLG-DAGHQSWVVT Mb1908|M.bovis_AF2122/97 ----NIIFTALVFG--VLVAATGQTIVVPALPTIVAELG-STVDQSWAVT MLBr_01562|M.leprae_Br4923 FPSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGIT MUL_2115|M.ulcerans_Agy99 ----RFIAAVIAIGGMQLLATMDSTVAIVALPKIQDELSLSDAGRSWVIT Mflv_2220|M.gilvum_PYR-GCK -----RTRMIIVLGLLVALGPLTIDMYLPALPKIGEELSVSSSVAQLTLT Mvan_4475|M.vanbaalenii_PYR-1 -----RTRMILVLGLLVALGPLTIDMYLPALPKIAEELSVSSSVAQLTLT MAB_1395|M.abscessus_ATCC_1997 L---GRAWLITVLGAMVALGPLTIDMYLPALPDIGSDLHVNSTLTQLTLT MSMEG_2991|M.smegmatis_MC2_155 T---PTLALIILLALLNAVTPFSVDMYMSAFPAMAVEFGTSASVVQLTLT TH_2729|M.thermoresistible__bu --------VLVALILTMALVAMDTTILATAVPQVVGDLG-GFDQVGWVFS MMAR_3524|M.marinum_M --------IVAVLLCVVPLNQIPMDAYTPALPQMETSIGTTATALQSTVT : : *.* : .: .: Rv1877|M.tuberculosis_H37Rv SYLLGGTVVVVVAGKLGDLLGRNRVLLGSVVVFVVGSVLCGLSQTMTMLA MAV_2832|M.avium_104 SYLLASTIVTALVGKLGDLYGRKRVFQAAVLFFVAGSVLCGLAQSMAMLV Mb1908|M.bovis_AF2122/97 SYLLGGTVVVVVAGKLGDLLGRNRVLLGSVVVFVVGSVLCGLSQTMTMLA MLBr_01562|M.leprae_Br4923 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLV MUL_2115|M.ulcerans_Agy99 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATLV Mflv_2220|M.gilvum_PYR-GCK GTLAGLAIGQLVIGPLSDSLGRRKPLFAGIVLHMVASLLCMFAPTITVLG Mvan_4475|M.vanbaalenii_PYR-1 GTLAGLAIGQLVIGPLSDSLGRRRPLFAGIVLHMLASLLCLLAPNITVLG MAB_1395|M.abscessus_ATCC_1997 GTLVGLGLGQLLVGPLSDSLGRRLPLIAGAILHIVASLAITIAPNIVVLG MSMEG_2991|M.smegmatis_MC2_155 TFLIGLATGQLFIGQLSDRLGRRGPLLVGIVACLVASLLCAVSPSIEVLI TH_2729|M.thermoresistible__bu GYLLAQTVTIPIYGKLADLYGRRPILIFGVVAFLIGSALSAASWNMATLA MMAR_3524|M.marinum_M VFMIGMALSYLAVGIMSDSWGRKPVLMGCAAALTVTSLACAAANNVAMLL : * :.* **. : * : * Rv1877|M.tuberculosis_H37Rv ISRALQGVGAGAISVTAYALAAEVVPLR-DRGRYQGVLGAVFGVNTVTGP MAV_2832|M.avium_104 GARALQGIGGGGITVTASALIGEVVPLR-ERGRYQGILGAVFGVTTVIGP Mb1908|M.bovis_AF2122/97 ISRALQGVGAGAISVTAYALAAEVVPLR-DRGRYQGVLGAVFGVNTVTGP MLBr_01562|M.leprae_Br4923 IARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGL MUL_2115|M.ulcerans_Agy99 IARLSQGVGSAIASPTGLALVATTFPKGPTRNAATAVFAAMTAVGSVMGL Mflv_2220|M.gilvum_PYR-GCK IARGLQGMGAAAGMVVAIAVVGDLYKDN-AAATVMSRLMLVLGVAPVLAP Mvan_4475|M.vanbaalenii_PYR-1 VARCLQGMGAAAGMVVAIAVVGDLYKDN-VAATVMSRLMLVLGVAPVLAP MAB_1395|M.abscessus_ATCC_1997 VLRAVEGMGAAAAMVVAMAVVRDLYTDK-AAATVISRLTLVIGIAPILAP MSMEG_2991|M.smegmatis_MC2_155 MLRFVQGFAGAAGIVIARAIISDRSKGS-QAAKLYSVMMVIGVLAPILAP TH_2729|M.thermoresistible__bu IFRAIQGLGAGAISATVQTVAGDLYTVA-ERGRIQGYLASVWGISAVIAP MMAR_3524|M.marinum_M VLRFLQGGACSAFIVVAIAIAADCFEGA-RLRSVNGLLGAAWSAAPILAP * :* . . :: . : .: . Rv1877|M.tuberculosis_H37Rv LLGGWLTDYLSWRWAFWINVPVSIAVLTVAATAVPALARPPKPVIDYLGI MAV_2832|M.avium_104 LLGGYFTDYLSWRWAFWVNVPVSVIVIFVAAAAIPALAASAKPVIDYAGI Mb1908|M.bovis_AF2122/97 LLGGWLTDYLSWRWAFWINVPVSIAVLTVAATAVPALARPPKPVIDYLGI MLBr_01562|M.leprae_Br4923 VVGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKE-RMKLDAAGA MUL_2115|M.ulcerans_Agy99 VVGGALTEVS-WRLAFMVNVPIGLVMIYLARTALRETNRE-RMKLDAAGA Mflv_2220|M.gilvum_PYR-GCK SLGAAVLLHGSWHWVFAALVVVAAALLVMAVLALPETLPVDHRRPLKVRG Mvan_4475|M.vanbaalenii_PYR-1 SFGAAVLLHGSWHWVFAALVVVAGALLVMSVLALPETLPADHRRPLKARG MAB_1395|M.abscessus_ATCC_1997 SLGAAVLVHGSWQNVFAALSCLGVLLLILAVVALPETLPPSARRPLRAGA MSMEG_2991|M.smegmatis_MC2_155 VLGGQVVAGFGWRAVFLALAGLNLVMLLGALFMAGESLPPEARRPAGLKA TH_2729|M.thermoresistible__bu ALGGFFAQYLTWRWIFLVNIPIGVFALYLIARDLHEDVVRRPHRIDYLGA MMAR_3524|M.marinum_M AVGGFIVEYASWRYVFVLIAALSVVVGLAVTWALPETLDQESRTRFELGQ .*. . *: * : Rv1877|M.tuberculosis_H37Rv LVIAVATTALIMATSWGGTTYAWGSATIVGLLIGAAVALGFFVWLEGRAA MAV_2832|M.avium_104 VFVGLGAAGLTLATSWGGSRYPWGSPTIIGLFAAAAVALGVFVVVERRAA Mb1908|M.bovis_AF2122/97 LVIAVATTALIMATSWGGTTYAWGSATIVGLLIGAAVALGFFVWLEGRAR MLBr_01562|M.leprae_Br4923 ILATLACTAAVFAFSMG-PEKGWISLTTIGSGLVALVAAIAFAVVERTAE MUL_2115|M.ulcerans_Agy99 ILATLACTAAVFAFSMG-PEKGWLSITTIGSGAVAFAAALGFVLVERTAE Mflv_2220|M.gilvum_PYR-GCK IAATYLELVRDARFVILVLVAALGMSGLFAYIAGASFVLQGRFGLDQTAF Mvan_4475|M.vanbaalenii_PYR-1 IALTYLELLRDVRFVILVFVGALGMSGLFAYIAGASFVLQGRFGLDQTAF MAB_1395|M.abscessus_ATCC_1997 ILRTYRDLLRDKVFVVLVLVAGLSLSGLFAYISGASFVLQGQYGMNQQVF MSMEG_2991|M.smegmatis_MC2_155 FAGSAASVLTNRRFMGYTLTLSCSGAAMFSYISASPFVLQNIIGLSPRAF TH_2729|M.thermoresistible__bu GLVLVSAGLFILGLLSGGVHWSWTSPTSVVVFTGAALAGVALLVVESRAA MMAR_3524|M.marinum_M TWQVLTATARNRVFLALAAIFGLLAGPQLSFGVAAPFLYQDEMGFSPSAY . : .. . Rv1877|M.tuberculosis_H37Rv AAILPPRLFGSPVFAVCCVLSFVVGFAMLGALTFVPIYLGYVDGASATAS MAV_2832|M.avium_104 EPILPVRLFASPVFTVCCVLSFVVGFAMLGAMTFLPTYMQYVDGVSATTS Mb1908|M.bovis_AF2122/97 CGHPAAQAVWQP--SICRVLRPVLRGRIR----------------DAGCT MLBr_01562|M.leprae_Br4923 NPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRA MUL_2115|M.ulcerans_Agy99 NPVVPFDLFHDRNRLVTFIAIFLAGGVMFSLTVCIGLYVQDVLGYSALRA Mflv_2220|M.gilvum_PYR-GCK ALVFGAGAVALIGTTQCNVILLKR-------------------------- Mvan_4475|M.vanbaalenii_PYR-1 ALVFGAGAIALIGTTQFNVVLLKR-------------------------- MAB_1395|M.abscessus_ATCC_1997 ALAFGAGAIAFVAASQLNVVLLKR-------------------------- MSMEG_2991|M.smegmatis_MC2_155 SFTFGGCALAVAVSGVISARLVGR-------------------------- TH_2729|M.thermoresistible__bu EPVLPLSMLTRRLTAPSFAATATAGMIVIGLSVYLPNWGQTVLGLSPVAA MMAR_3524|M.marinum_M GLIALVVGVAVLLGSFSTGMLATR-------------------------- . Rv1877|M.tuberculosis_H37Rv GLRTLPMVIGLLIASTGTGVLVGRTGRYKIFPVAGMALMAVAFLLMSQMD MAV_2832|M.avium_104 GLRTLPMVVGMLFTSTGSGTIVGRTGRYKIFPVAGTALMALAFLLMSRMQ Mb1908|M.bovis_AF2122/97 DLR-----------TDLSGVRGRRVG-----DRVRSAHVADGDRPADRLD MLBr_01562|M.leprae_Br4923 GIGFIPFVIAMGIGLGVSSQLVSRFS-------PRVLTIGGGWLLMVAML MUL_2115|M.ulcerans_Agy99 GVGFIPFVIAMGIGLGVSSQLVSRFS-------PRVLTIGGGYLLVCAMI Mflv_2220|M.gilvum_PYR-GCK --------------FTPQQIMVWALA--------ASSVFGLVFVALAAAG Mvan_4475|M.vanbaalenii_PYR-1 --------------FAPQQIMVWALV--------AASLSGAVFVALAAAH MAB_1395|M.abscessus_ATCC_1997 --------------FEPQQIVRWCLS--------LALIPAVVLLVLAGFG MSMEG_2991|M.smegmatis_MC2_155 --------------FGPRKLLLGGVS--------AMVVVAALMLLNVTVG TH_2729|M.thermoresistible__bu GFVLAIMSITWPISSGFSARLYLRIG------FRDTALVGASCAVAAGTG MMAR_3524|M.marinum_M --------------MAFRRLAFADWT---------LYMVGAALLLGSAPV . Rv1877|M.tuberculosis_H37Rv EWTPPLLQSLYLVVLGAGIGLSMQVLVLIVQNTSSFEDLGVATSGVTFFR MAV_2832|M.avium_104 PSTSAVIQSLYLFILGAGIGLSMQVLILIVQNTSDFEDLGVATSGVTFFR Mb1908|M.bovis_AF2122/97 RDGCPGRP------------------------DGPLQDLPGRGDG----- MLBr_01562|M.leprae_Br4923 YG-------------------------------WAFMNRG---------- MUL_2115|M.ulcerans_Agy99 YG-------------------------------WAFMQRG---------- Mflv_2220|M.gilvum_PYR-GCK VG------------------------------------------------ Mvan_4475|M.vanbaalenii_PYR-1 IG------------------------------------------------ MAB_1395|M.abscessus_ATCC_1997 IG------------------------------------------------ MSMEG_2991|M.smegmatis_MC2_155 GV------------------------------------------------ TH_2729|M.thermoresistible__bu LVLLG--------------------------------------------- MMAR_3524|M.marinum_M VG------------------------------------------------ Rv1877|M.tuberculosis_H37Rv VVGASFGTATFGALFVNFLDRRLGSALTSGAVPVPAVPSPAVLHQLPQSM MAV_2832|M.avium_104 TIGSSFGAAIFGSLFVNFLNRRIGPALAASGAPPGAVSSPGALHRQPHEV Mb1908|M.bovis_AF2122/97 --------ADGGCVPADVADGRVDATAAAIAVPG----RPRCRHRIVHAG MLBr_01562|M.leprae_Br4923 -------VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSA MUL_2115|M.ulcerans_Agy99 -------VPYFPNLVAPIVIGGIGIGMAVVPLTLAAIAGVGFDRIGPVSA Mflv_2220|M.gilvum_PYR-GCK ---------GVFGFVIPVWAILAAMGLVIPNAPAVALTRHPDAAGTAAAL Mvan_4475|M.vanbaalenii_PYR-1 ---------GLWGFVIPVWAILAAMGLVIPNAPAVALTRHPDAAGTAAAL MAB_1395|M.abscessus_ATCC_1997 ---------GLVGFVAPVWTLMALMGFVIPNAPALALSRHGEAAGTSAAV MSMEG_2991|M.smegmatis_MC2_155 ---------VPAVTVALMACFMGTVGFTFANATTLAIGEVRHAAGTGSAV TH_2729|M.thermoresistible__bu ------PAPPVWQPVVYTALMGAGMGLLFSPLIVGLQNTVGWDQRGTVTG MMAR_3524|M.marinum_M --------VNPWAITLAVSLAVAGCGALVPQAQAAALGAFSRNLGLVSGL Rv1877|M.tuberculosis_H37Rv AAPIVRAYAESLTQVFLCAVSVTVVGFILALLLREVPLTDIHDDADDLGD MAV_2832|M.avium_104 AAPIVAAYAESLTEVFFWAAPVALVGFVLALFLREIPLRDIHDSTVDLGD Mb1908|M.bovis_AF2122/97 AR------SHRAEHVVFRRP------------------------------ MLBr_01562|M.leprae_Br4923 IALMLQSLGGPLVLAVIQAVITS--------------------------- MUL_2115|M.ulcerans_Agy99 LTLMLQSLGGPLVLAGIQAVITS--------------------------- Mflv_2220|M.gilvum_PYR-GCK LGAVQFGGGAAIAPVVGVLGND---------------------------- Mvan_4475|M.vanbaalenii_PYR-1 LGAVQFGMGAAIAPVVGVLGND---------------------------- MAB_1395|M.abscessus_ATCC_1997 LGAAQFGVGAVIAPLVGALGNN---------------------------- MSMEG_2991|M.smegmatis_MC2_155 IGFLQYGLGAVASPLVGLAGEHS--------------------------- TH_2729|M.thermoresistible__bu GLMFSRFLGQSIGAAGFGAVANAVLR------------------------ MMAR_3524|M.marinum_M FGTLTYLIIAAIMAIVGVSPERT--------------------------- Rv1877|M.tuberculosis_H37Rv GFGVPRAESPEDVLEIAVRRMLP--NGVRLRDIATQPGCGLGVAELWALL MAV_2832|M.avium_104 AFGMPTTETPDQMLENAIARMLRGETGMRLRSIAMRPDCRLDVAGLWGVL Mb1908|M.bovis_AF2122/97 ----RRRNIGCDL--------------------------------LPGGR MLBr_01562|M.leprae_Br4923 -------------------------------------------------- MUL_2115|M.ulcerans_Agy99 -------------------------------------------------- Mflv_2220|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_4475|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1395|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 -------------------------------------------------- TH_2729|M.thermoresistible__bu -------------------------------------------------- MMAR_3524|M.marinum_M -------------------------------------------------- Rv1877|M.tuberculosis_H37Rv RIYQYQRLFEAVRLTDIGRHLHVPYQVFEPVFDRLVQTGYAARDGDILTL MAV_2832|M.avium_104 RINRYTQMYGTARLTDMAEYLRIPFEVLEPTFSRLVTAGYAGSDGDRLWL Mb1908|M.bovis_AF2122/97 RLVWYRNIRCVVR------KLPGPKTRFRADVGRRACPGSAIS-GCLASA MLBr_01562|M.leprae_Br4923 RTLYLGGTTGPVKFMN---DAQLRALDHGYTYGLLWVAGAVVIVGVAALF MUL_2115|M.ulcerans_Agy99 RTLYLGGTTGPVKFMN---DAQLHALDHGYTYGLLWVAGAAVIVGGAAVF Mflv_2220|M.gilvum_PYR-GCK ----------------------------ELAMAVVMAAGVIIALGALLVT Mvan_4475|M.vanbaalenii_PYR-1 ----------------------------ELAMAVVMAAGVIVALTALLVT MAB_1395|M.abscessus_ATCC_1997 ----------------------------ALAVAIVMMIGVVLALAGLAVV MSMEG_2991|M.smegmatis_MC2_155 ----------------------------AVPMGVAMFTCAALAATALLVL TH_2729|M.thermoresistible__bu ----------------------------RYEPDTSAAAMGAASHAVFVGL MMAR_3524|M.marinum_M ----------------------------QAPLGWLYVLCGALVFAALAWV Rv1877|M.tuberculosis_H37Rv TPSGHRQVDSLAVLIRQWLLDHLAVAPGLKRQPD-HQFEAALQHVTDAVL MAV_2832|M.avium_104 TPAGAQQVGYVHSLLLAWLVDKLGRSPGFEGRPDRQAVQAALERVAYRVL Mb1908|M.bovis_AF2122/97 APEHGRPDRAGICRVAHPGVPLRGLGHGGRFHPG---------AVAARGT MLBr_01562|M.leprae_Br4923 IGYTPEQVAYAQEVKEAVDAGEL--------------------------- MUL_2115|M.ulcerans_Agy99 IGYTPEQVAHAQEVKEAIDAGEL--------------------------- Mflv_2220|M.gilvum_PYR-GCK GAHRNTEPARVPDEAVAEPA------------------------------ Mvan_4475|M.vanbaalenii_PYR-1 GVHRNTAPAAVPGEAVAEPA------------------------------ MAB_1395|M.abscessus_ATCC_1997 ---RNRVAA----------------------------------------- MSMEG_2991|M.smegmatis_MC2_155 TRGHIPSYDDELADLDADLTAVSAGESTAR-------------------- TH_2729|M.thermoresistible__bu LVAAVATVVLLLTVPRRFPTHHVAVVD----------------------- MMAR_3524|M.marinum_M TPRVQGEKPTPG-------------------------------------- Rv1877|M.tuberculosis_H37Rv VQRDWYEDLGDLSESRQLAATT MAV_2832|M.avium_104 AQRDWHDAQPTAAIT---AAAR Mb1908|M.bovis_AF2122/97 AHRHPR---------------- MLBr_01562|M.leprae_Br4923 ---------------------- MUL_2115|M.ulcerans_Agy99 ---------------------- Mflv_2220|M.gilvum_PYR-GCK ---------------------- Mvan_4475|M.vanbaalenii_PYR-1 ---------------------- MAB_1395|M.abscessus_ATCC_1997 ---------------------- MSMEG_2991|M.smegmatis_MC2_155 ---------------------- TH_2729|M.thermoresistible__bu ---------------------- MMAR_3524|M.marinum_M ----------------------