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AYMAAIDARHLDGVSETALITLNQRATEANRPDGVLEDPMAIVLRDSLDYDYHHFGRTHQGIALRALTFD TVSNEYLAEHPRATVVALAEGLQTSFWRIDNGELNWLSVDLEPIVRLRRQLLPPSDRVRYVAQSALDHSW MDQVDDSNGVLITAEGLFMYLERDVVFDLIAACAKRFPGGWMVFDTIPWLMSVYSRRRGWRLSEHYTVPP MPFSFTAHQYGQLRALDGVSAVREVRMPAGRGTFLKLATPLFYNLPLSDRIRPAMTVVEFG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1292c | - | - | 100% (272) | O-methyltransferase OMT |
| M. abscessus ATCC 19977 | MAB_0668c | - | e-106 | 69.89% (269) | O-methyltransferase OmT |
| M. abscessus ATCC 19977 | MAB_1295c | - | 9e-68 | 50.18% (273) | O-methyltransferase OMT |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 6e-73 | 53.96% (265) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_5259 | - | 2e-71 | 52.43% (267) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 6e-74 | 54.34% (265) | O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_0262 | omt_1 | 1e-114 | 72.49% (269) | O-methyltransferase Omt_1 |
| M. avium 104 | MAV_2991 | - | 4e-24 | 35.57% (194) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. smegmatis MC2 155 | MSMEG_5173 | - | 1e-74 | 53.56% (267) | O-methyltransferase, putative |
| M. thermoresistible (build 8) | TH_0460 | omt | 4e-72 | 52.81% (267) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_4852 | omt_1 | 1e-111 | 71.00% (269) | O-methyltransferase Omt_1 |
| M. vanbaalenii PYR-1 | Mvan_0979 | - | 7e-73 | 51.84% (272) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0262|M.marinum_M ----MPVIDAR-HLDGISETALLTLHQRATEAARPDAIIDDPMAIALRND
MUL_4852|M.ulcerans_Agy99 ----MPVIDAR-HLDDISETALLTLHQRATEAARPDAIIDDPMAIALRND
MAB_1292c|M.abscessus_ATCC_199 -MAYMAAIDAR-HLDGVSETALITLNQRATEANRPDGVLEDPMAIVLRDS
MSMEG_5173|M.smegmatis_MC2_155 -MTTDATARTRVSLTGVSETALLTLQVRANEARRPDGLIKDPMAVQLVDS
TH_0460|M.thermoresistible__bu -VSSGPLAKP--ELTGVSETALLTLLVRATEARRPDGIIDDPMAVRLVDS
Mflv_5259|M.gilvum_PYR-GCK ------------MLAGVSETALLTLNGRAYQARHPNAILDDPMAIRVVDS
Mvan_0979|M.vanbaalenii_PYR-1 -MDQDGKIDAG-ALAGVSETALLTLNGRAYQARHPNAIIDDPMAIRLVDA
Mb1184c|M.bovis_AF2122/97 -MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDTIIDDPMAVALVES
Rv1153c|M.tuberculosis_H37Rv -MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDAIIDDPMAVALVES
MAV_2991|M.avium_104 MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAAAEAVDR
.:. * *:** ** :: : :: *. * :
MMAR_0262|M.marinum_M IDYPYHHFGR------THQATALRALAFDNSTRDFLRTHPGATVVALAEG
MUL_4852|M.ulcerans_Agy99 IDYPYHHFGR------THQATALRALAFDNSTRDFLQTRPGATVVALAEG
MAB_1292c|M.abscessus_ATCC_199 LDYDYHHFGR------THQGIALRALTFDTVSNEYLAEHPRATVVALAEG
MSMEG_5173|M.smegmatis_MC2_155 IDFDFAKFGHS-----HRQDMALRSLIFDRATSDYLRDHPKATVVALAEG
TH_0460|M.thermoresistible__bu IDFDFAKFGPS-----RRQDMALRAKAFDTATRRYLRAHPKATVVALAEG
Mflv_5259|M.gilvum_PYR-GCK IDFDFDKFGRR-----KGQEMALRSLAFDRAATAYLAKHPKATVVALAEG
Mvan_0979|M.vanbaalenii_PYR-1 IDFDFDKFGRR-----KGQEMALRSLAFDRAATRYLSRHPAATVVALAEG
Mb1184c|M.bovis_AF2122/97 IDFGFAKFGP------TGQGFALRARAFDMAAQHYLDQHPAATVVALAEG
Rv1153c|M.tuberculosis_H37Rv IDFDFAKFGP------TGQGFALRARAFDMAAQHYLDQHPAATVVALAEG
MAV_2991|M.avium_104 IRYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDAVVLHLGCG
: : : :: ***: ** :* :* *.*: *. *
MMAR_0262|M.marinum_M LQTSFWRLD----NGELNWLSVDLAPIVRLREQLLPACDRLRYCAQSAFD
MUL_4852|M.ulcerans_Agy99 LQTSFWRLD----NGELNWLSVDLAPIVRLREQLLPACDRLRYCAQSAFD
MAB_1292c|M.abscessus_ATCC_199 LQTSFWRID----NGELNWLSVDLEPIVRLRRQLLPPSDRVRYVAQSALD
MSMEG_5173|M.smegmatis_MC2_155 LQTSFYRLNEAGVGDQFCWLTVDLPPMVEIRNKLLPPSDRVRTCAQSALD
TH_0460|M.thermoresistible__bu LQTSFFRLNAADVGDEFRWVTVDLAPVIELRRQLLPADDRVTMLAQSALD
Mflv_5259|M.gilvum_PYR-GCK LQTSFWRLDAALPTAEFRWLTVDFEPIIELRRRLLPESARITTLAQSALD
Mvan_0979|M.vanbaalenii_PYR-1 LQTSFWRLDAAIPDSRFRWVSIDLEPVIALRRRLLPDSPRITTLAQSALD
Mb1184c|M.bovis_AF2122/97 LQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSALD
Rv1153c|M.tuberculosis_H37Rv LQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSALD
MAV_2991|M.avium_104 LDGRAFRVS---VPPSLSWFDVDQPSVIGLRRRLYDDTENYRMIGSSVTE
*: :*:. : *. :* .:: :* :* . ..*. :
MMAR_0262|M.marinum_M YSWMEQVDDTNGVLITAEGLFQYLRRDVVFELIAACAKRFPHGQLVFDSI
MUL_4852|M.ulcerans_Agy99 YSWMEQVDDTNGVLITAEGLFQYLRRDVVFELIAACAKRVPHGQLVFDSI
MAB_1292c|M.abscessus_ATCC_199 HSWMDQVDDSNGVLITAEGLFMYLERDVVFDLIAACAKRFPGGWMVFDTI
MSMEG_5173|M.smegmatis_MC2_155 YSWMDQVDDSEGVFITAEGLLMYLQPEESMGLIKECARRFPGGQMIFDLP
TH_0460|M.thermoresistible__bu YSWMDRIDTSEGVFITAEGLLMYLQPDEAMGLIRECARRFPGGQMMFDLP
Mflv_5259|M.gilvum_PYR-GCK YSWMDAVDTTHGVFITAEGLLMYLQPEESMGLITECAARFPGAQMIFDLP
Mvan_0979|M.vanbaalenii_PYR-1 YSWMDAVDTTDGVFITAEGLLMYLQPDEAMDLITACASRFPGGQMIFDLP
Mb1184c|M.bovis_AF2122/97 YSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFDLP
Rv1153c|M.tuberculosis_H37Rv YSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFDLP
MAV_2991|M.avium_104 LQWLDEVPAGRPTLMVAEGLLMYLREDEVRRLLQRLIDRFPGGEMHFDTL
.*:: : .::.****: **. : *: .* . : **
MMAR_0262|M.marinum_M PWLLSVYSRRRGFRLSEHYTAPPMPFWFTADHYDELR-AIPGVRAVRELP
MUL_4852|M.ulcerans_Agy99 PWLLSVYSRRRGFKLSEHYTAPPMPFWFTADHYDELR-AIPGVRAVRELP
MAB_1292c|M.abscessus_ATCC_199 PWLMSVYSRRRGWRLSEHYTVPPMPFSFTAHQYGQLR-ALDGVSAVREVR
MSMEG_5173|M.smegmatis_MC2_155 PSWFAAWAR-KGMRTSRRYRVPPMPFSLSPAEVADLVNTVPGVRVVHDLP
TH_0460|M.thermoresistible__bu PSFFAWLTR-RGFRTSLRYKVPPMPFTLSPEQAADLVNTVPGVQAVHDVP
Mflv_5259|M.gilvum_PYR-GCK PVMVKKFAP-KGVRSSSRYRVPPMPFSLSAAELADLVHTVPGVRAVHDLP
Mvan_0979|M.vanbaalenii_PYR-1 PTMVKKIAP-KGMRSSARYRVPPMPFSLSPAQLAELVHTVPGVTAVHDLP
Mb1184c|M.bovis_AF2122/97 PRWFAGWSR-LGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRDLR
Rv1153c|M.tuberculosis_H37Rv PRWFAGWSR-LGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRDLR
MAV_2991|M.avium_104 SALAPLLSK----------VFTRGIITWGIRDARRIADWNPRLRFLEQSP
. : . : . : : :.:
MMAR_0262|M.marinum_M APAGRGRFLRWALPVAYRLPGLGRLRAPVTLVEFG-------
MUL_4852|M.ulcerans_Agy99 APAGRGRFLRWALPVAYRLPGLGRLRAPVTLVEFG-------
MAB_1292c|M.abscessus_ATCC_199 MPAGRGTFLKLATPLFYNLPLSDRIRPAMTVVEFG-------
MSMEG_5173|M.smegmatis_MC2_155 FPPARGKFMRTVVWGVQRLPLFDPIRPVMALLEFG-------
TH_0460|M.thermoresistible__bu IPRGRGVLVNTLIWAAQRTPLFDNVRGTYTLLEFGPPNSAST
Mflv_5259|M.gilvum_PYR-GCK MPQGRGFFFEKVFPAFWGLKATKNYRGAYTLLEFG-------
Mvan_0979|M.vanbaalenii_PYR-1 MPRGRGFLFERVFPAFWQFKPTRNYRGAYTLLEFG-------
Mb1184c|M.bovis_AF2122/97 VPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
Rv1153c|M.tuberculosis_H37Rv VPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
MAV_2991|M.avium_104 ALAGYQRIPSTVVRSIYRLTWLTGGRGYDVLNRFEY------
. * .: .*