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MSKAEVREIGVSETGFVRRPDPDGAAVAYRTYGRSRPGVVDVVLVHGSLQNSAVWSKHGYIAQLSQQYRV TTIDVRGHGASEKPDHPGGYAIASSARDVCAVLDHLQVHQAHYLGYSLGGRIGLTLAATAPERLTSLVVA GSSHRPQRGAVDVLIFPNAIRVVEESGLPAFIDGWESHRGQRMASGFRATIEALGQRGLAALLRQWDDEP GVTEEALLQIETPTLFFAGSEDPMRLAESREAAVRMPRAYFALLEGCNHGQTVTMRERILDRAEAFFRLS EFSDIEKLRVAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1169 | - | - | 100% (292) | putative hydrolase, alpha/beta fold |
| M. abscessus ATCC 19977 | MAB_0349c | - | 3e-10 | 23.58% (246) | putative hydrolase, alpha/beta fold |
| M. abscessus ATCC 19977 | MAB_3880 | - | 6e-10 | 24.59% (305) | lipase/esterase LipG |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 6e-10 | 30.69% (101) | hydrolase |
| M. gilvum PYR-GCK | Mflv_1348 | - | 9e-15 | 30.09% (226) | 3-oxoadipate enol-lactonase |
| M. tuberculosis H37Rv | Rv2715 | - | 7e-10 | 30.69% (101) | hydrolase |
| M. leprae Br4923 | MLBr_01899 | lipG | 1e-07 | 26.84% (190) | putative hydrolase |
| M. marinum M | MMAR_0983 | lipG2 | 8e-12 | 28.23% (294) | lipase/esterase LipG2 |
| M. avium 104 | MAV_4120 | - | 1e-09 | 35.05% (97) | hydrolase, alpha/beta fold family protein, putative |
| M. smegmatis MC2 155 | MSMEG_1897 | pcaD | 2e-12 | 31.73% (208) | 3-oxoadipate enol-lactonase |
| M. thermoresistible (build 8) | TH_2963 | - | 2e-13 | 27.20% (261) | PUTATIVE putative 3-oxoadipate enol-lactonase |
| M. ulcerans Agy99 | MUL_0735 | lipG2 | 7e-12 | 28.73% (268) | lipase/esterase LipG2 |
| M. vanbaalenii PYR-1 | Mvan_4414 | - | 3e-13 | 27.11% (273) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2734|M.bovis_AF2122/97 --------MTERKRNLRPVRDVAPPTLQFRTVHGYRRAFRIAGSGPAILL
Rv2715|M.tuberculosis_H37Rv --------MTERKRNLRPVRDVAPPTLQFRTVHGYRRAFRIAGSGPAILL
Mflv_1348|M.gilvum_PYR-GCK ---------------------MSAVDVHVIESG--------LPDGPAVVL
MSMEG_1897|M.smegmatis_MC2_155 ---------------------MSSVAVHHVVTG--------RSDGPAVVF
MMAR_0983|M.marinum_M --------MRTSSGVARRETTTGDVELFYEELG--------DPSGQPVLL
MUL_0735|M.ulcerans_Agy99 --------MR----AARRLRAT--SKLFYEELG--------DPSGQPVLL
MLBr_01899|M.leprae_Br4923 --------ME----VRSGYATSGDLKLYYEDMG--------NVDDPPVLL
TH_2963|M.thermoresistible__bu ----------------MPRFSRAGTTIDYTDTG------APAGRLEAPTI
MAB_1169|M.abscessus_ATCC_1997 MSKAEVREIGVSETGFVRRPDPDGAAVAYRTYG------RSRPGVVDVVL
Mvan_4414|M.vanbaalenii_PYR-1 ------MSSEITEQYTSRDIETKSGTIHYNEAG----------EGYPIVM
MAV_4120|M.avium_104 ---------MTTEVASTTVTATDGVRLAVHTYTG------IDPARPTVLA
:
Mb2734|M.bovis_AF2122/97 IHGIGDNSTTWNGVHAK---LAQRFTVIAPDLLGHGQSDKPR--------
Rv2715|M.tuberculosis_H37Rv IHGIGDNSTTWNGVHAK---LAQRFTVIAPDLLGHGQSDKPR--------
Mflv_1348|M.gilvum_PYR-GCK SNSLGATHRMWDAQLDA---LERRFRVLRYDTRGHGASPVPD--------
MSMEG_1897|M.smegmatis_MC2_155 SNSLGSTHRMWDPQLAA---FEERFRVVRYDTRGHGQSPVPE--------
MMAR_0983|M.marinum_M IMGLGAQLPMWPDEFCARL-VTAGYRVIRFDHRDTGLSAKMRGMRAPG--
MUL_0735|M.ulcerans_Agy99 IMGLGAQLPMWPDEFCARL-VAAGYRVIRFDHRDTGLSAKMRGMRAPG--
MLBr_01899|M.leprae_Br4923 IMGLGAQLVLWRTAFCEKL-VAQGLRVVRYDNRDVGLSSRTDSTEQPCPS
TH_2963|M.thermoresistible__bu LFGHGLLFSGWQFNLQIYA-LRRYYRCLAIDWRGQGASSGAAR-------
MAB_1169|M.abscessus_ATCC_1997 VHGSLQNSAVWSKHGYIAQ-LSQQYRVTTIDVRGHGASEKPDHP------
Mvan_4414|M.vanbaalenii_PYR-1 LHGSGPGATGWSNFGSNIKGLADRFRVIAADMPGWGQSEAVKP-------
MAV_4120|M.avium_104 IHGYPDNHHVWDGVAAA---LRRRFNVVAYDVRGAGQSSTPPER------
. * . * . * *
Mb2734|M.bovis_AF2122/97 -----------------ADYSVAAYANGMRDLLSVLDIERVTIVGHSLGG
Rv2715|M.tuberculosis_H37Rv -----------------ADYSVAAYANGMRDLLSVLDIERVTIVGHSLGG
Mflv_1348|M.gilvum_PYR-GCK -----------------GPYSIDDLADDVVGILDRRGIDTAHLVGLSLGG
MSMEG_1897|M.smegmatis_MC2_155 -----------------GPYTIDDLADDVVALLDTLGIERAHVVGLSLGG
MMAR_0983|M.marinum_M -SVYRRIGRYLLGRPSPVPYTLLDMTEDVAALLDHLSIARAHVVGASLGG
MUL_0735|M.ulcerans_Agy99 -SVYRRIGRYLLGRPSPVPYTLLDMTEDVAALLDHLSIARAHVVGASLGG
MLBr_01899|M.leprae_Br4923 QPLTARLIRFWLGQRNACAYTLEDMTDDAVALLDHLSIERAHIVGASMGG
TH_2963|M.thermoresistible__bu ------------------PYDMDTLTEDAAHLVRSLGVAPAHYVGLSMGG
MAB_1169|M.abscessus_ATCC_1997 -----------------GGYAIASSARDVCAVLDHLQVHQAHYLGYSLGG
Mvan_4414|M.vanbaalenii_PYR-1 --------------------DARDHVAAALQLLDGLGIEKAAFVGNSMGG
MAV_4120|M.avium_104 -----------------SGYRLEQLVADVDAVIGRLGVDSVHLLAHDWG-
. :: : . :. . *
Mb2734|M.bovis_AF2122/97 GVAMQFAYQFPQLVDRLILVSAGGVTKDVNIV-FRLASLPMGSEAMALLR
Rv2715|M.tuberculosis_H37Rv GVAMQFAYQFPQLVDRLILVSAGGVTKDVNIV-FRLASLPMGSEAMALLR
Mflv_1348|M.gilvum_PYR-GCK MTAMRVAARNPDRVNRMVLLCTAA--ELAPAQ-AWTDRAAAVRAGGAESV
MSMEG_1897|M.smegmatis_MC2_155 MTAMRLSARNPQRVDRIALLCTAT--HLPPSS-AWTERAAAVRTHGSAAV
MMAR_0983|M.marinum_M MIAQILAADRPQRVASLGIIMSTTGKAFSAPP-AWRVIKLAFGQPGPNAS
MUL_0735|M.ulcerans_Agy99 MIAQILAADQPQRVASLGIIMSTTGKAFSAPP-AWRVIKLAFGQPGPNAS
MLBr_01899|M.leprae_Br4923 MIAQIFAARFPTRTRSLAVFFSSNNRPFLPPP-APRALLALLTGPPTGSR
TH_2963|M.thermoresistible__bu FVGIRLAARHPELVRSLVLMNTSAGPEDPAKADRYRTMARIYRFTGIGPL
MAB_1169|M.abscessus_ATCC_1997 RIGLTLAATAPERLTSLVVAGSSHRPQRGAVD--VLIFPNAIRVVEESGL
Mvan_4414|M.vanbaalenii_PYR-1 GTAIQFAVAHPDRISHLITMGSRAPGPTIIGPDGLTEGLKTLLKGYTDPS
MAV_4120|M.avium_104 SIQGWAAVTDESVMGKIASFTSISGPHLNYAG---RFLRSARTPGGVLDV
: : :
Mb2734|M.bovis_AF2122/97 LPLVLPAVQIAGRIVGKAIGTTSLGHDLPNVLRILDDLPEPTASAAFGRT
Rv2715|M.tuberculosis_H37Rv LPLVLPAVQIAGRIVGKAIGTTSLGHDLPNVLRILDDLPEPTASAAFGRT
Mflv_1348|M.gilvum_PYR-GCK APAVIARWFTLSHLETHP---------AERAEWVDMIAATPAEGYASCCE
MSMEG_1897|M.smegmatis_MC2_155 AESVVGRWFTPGFLAADP---------GRKAAYQQMIAATPAEGYAGCCE
MMAR_0983|M.marinum_M AEEKLAFEVRNVAVFNGPNFLPPQSDLRQRVRLLADRCNYPPGMLRQFDA
MUL_0735|M.ulcerans_Agy99 AEEKLAFEVRNVAVFNGPNFLPPQSDLRQRVRLLADRCNYPPGMLRQFDA
MLBr_01899|M.leprae_Br4923 RDVVVDNVVRVTKITGSPLYRMPEEQVRTNAAEIYDRSFYPLGVSRQFSA
TH_2963|M.thermoresistible__bu RRAVLPLMFGPAFLADPD---------SEDVIDEWERRLRRYPRSSVRDA
MAB_1169|M.abscessus_ATCC_1997 PAFIDGWESHRGQRMASG--------FRATIEALGQRGLAALLRQWDDEP
Mvan_4414|M.vanbaalenii_PYR-1 PTSMRELVEIMTYDSANA---------TDELVQQRYAAAIGRPDHLENFM
MAV_4120|M.avium_104 VKQILASSYIWFFLAPGAPEWAIRSGATVKVFEAVERIGSTTAGAQRGAG
Mb2734|M.bovis_AF2122/97 LRAVVDWRGQMVTMLDRCY----------LTEAIPVQIIWGTKDVVLPVR
Rv2715|M.tuberculosis_H37Rv LRAVVDWRGQMVTMLDRCY----------LTEAIPVQIIWGTKDVVLPVR
Mflv_1348|M.gilvum_PYR-GCK AIAELDLREQLPTITA------------------PTLAIAGADDPATPPA
MSMEG_1897|M.smegmatis_MC2_155 AIAALDLRADLARITA------------------PTLAIAGTDDPATPPD
MMAR_0983|M.marinum_M VLGTGSLLGYSKAITA------------------PTVVLHGSADPMVRLR
MUL_0735|M.ulcerans_Agy99 VLGTGSLLGYSKAITA------------------PTVVLHGSADPMVRLR
MLBr_01899|M.leprae_Br4923 ILGSGSLLHYNQRIIA------------------PTVVIHGRADKLVRPS
TH_2963|M.thermoresistible__bu VLAVANRAGVEDELAAID---------------VPTLVIGGAQDAATPPA
MAB_1169|M.abscessus_ATCC_1997 GVTEEALLQIET----------------------PTLFFAGSEDPMR-LA
Mvan_4414|M.vanbaalenii_PYR-1 IAGLLGIPQATVEEIAG--------------IETPTLIFHGKDDRVVSYE
MAV_4120|M.avium_104 YRSTDDYLNGLNLYRANMPGPILSPPARLPQTSVPVQVLVARRDYFVSPA
*. : . *
Mb2734|M.bovis_AF2122/97 HAHMAHAAMPGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQ
Rv2715|M.tuberculosis_H37Rv HAHMAHAAMPGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQ
Mflv_1348|M.gilvum_PYR-GCK KLEQIVSAIPGARLLVVDGAAHLANAEQPEQITPAIIEHL--EQR-----
MSMEG_1897|M.smegmatis_MC2_155 RLAEITAAVRGARLVQVTPGAHLANVEQADAITPTLLEHLGTEQS-----
MMAR_0983|M.marinum_M NGRAVAAAIPDARFVVVDGMGHDLPQPVWRPILETLTENFSRAAPPHV--
MUL_0735|M.ulcerans_Agy99 NGRAVAAAIPDARFVVVDGMGHDLPQPVWRPILETLTENFSRAAPPHV--
MLBr_01899|M.leprae_Br4923 SGRAVARAITGARLVLFDGMGHDLPQQLWDQAVGVLMSNFAKAS------
TH_2963|M.thermoresistible__bu HAQALAAGIRGARLEIIDDCGHSSPLERPDVVTELLRGFLLEHT------
MAB_1169|M.abscessus_ATCC_1997 ESREAAVRMPRAYFALLEGCNHGQTVTMRERILDRAEAFFRLSEFSDIEK
Mvan_4414|M.vanbaalenii_PYR-1 AALKLVSLIRDSRVVLINRCGHWLQTEHSDEFNRLVADFVSNR-------
MAV_4120|M.avium_104 LQRFTGSIPDGSRVVPIDG-GHWVVNSHPDVIARLTGDWVDLTTRPAGGH
: . . * .
Mb2734|M.bovis_AF2122/97 AALRALLRRGGGEATVTGSADTRVAVLNAIGSNERSAT
Rv2715|M.tuberculosis_H37Rv AALRALLRRGGGEATVTGSADTRVAVLNAIGSNERSAT
Mflv_1348|M.gilvum_PYR-GCK --------------------------------------
MSMEG_1897|M.smegmatis_MC2_155 --------------------------------------
MMAR_0983|M.marinum_M --------------------------------------
MUL_0735|M.ulcerans_Agy99 --------------------------------------
MLBr_01899|M.leprae_Br4923 --------------------------------------
TH_2963|M.thermoresistible__bu --------------------------------------
MAB_1169|M.abscessus_ATCC_1997 LRVAG---------------------------------
Mvan_4414|M.vanbaalenii_PYR-1 --------------------------------------
MAV_4120|M.avium_104 HTGQT---------------------------------