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SSEITEQYTSRDIETKSGTIHYNEAGEGYPIVMLHGSGPGATGWSNFGSNIKGLADRFRVIAADMPGWGQ SEAVKPDARDHVAAALQLLDGLGIEKAAFVGNSMGGGTAIQFAVAHPDRISHLITMGSRAPGPTIIGPDG LTEGLKTLLKGYTDPSPTSMRELVEIMTYDSANATDELVQQRYAAAIGRPDHLENFMIAGLLGIPQATVE EIAGIETPTLIFHGKDDRVVSYEAALKLVSLIRDSRVVLINRCGHWLQTEHSDEFNRLVADFVSNR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4414 | - | - | 100% (277) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_5307 | - | 1e-43 | 37.81% (283) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_2898 | - | 9e-42 | 34.51% (284) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 9e-43 | 36.93% (287) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. gilvum PYR-GCK | Mflv_1464 | - | 9e-46 | 38.60% (285) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3569c | bphD | 9e-43 | 36.93% (287) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | MLBr_01899 | lipG | 2e-07 | 27.18% (206) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3810 | - | 3e-43 | 35.31% (286) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_5064 | bphD | 1e-44 | 38.03% (284) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. avium 104 | MAV_0592 | - | 2e-43 | 36.21% (290) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase |
| M. smegmatis MC2 155 | MSMEG_6037 | - | 3e-45 | 38.06% (289) | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase |
| M. thermoresistible (build 8) | TH_1741 | - | 2e-47 | 39.24% (288) | 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE BPHD |
| M. ulcerans Agy99 | MUL_4140 | bphD | 1e-44 | 38.03% (284) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4414|M.vanbaalenii_PYR-1 ---------MSSEITEQYTSRDIETKS----GTIHYNEAG-----EGYPI
MAB_3810|M.abscessus_ATCC_1997 -----------MDVTYEGTKRELATDE----GTLRYHEAGTA--GEGEPL
Mb3600c|M.bovis_AF2122/97 -------MTATEELTFESTSRFAEVDV-DGPLKLHYHEAGV---GNDQTV
Rv3569c|M.tuberculosis_H37Rv -------MTATEELTFESTSRFAEVDV-DGPLKLHYHEAGV---GNDQTV
MMAR_5064|M.marinum_M ---MTVTQSKTAEHTFESTSRYAEVDV-DGPLKLHYHEAGV---GNDQTV
MUL_4140|M.ulcerans_Agy99 ---MTVTQSKTAEHTFESTSRYAEVDV-DGPLKLHYHEAGV---GNDQTV
MAV_0592|M.avium_104 -------MTATEELTFESTSRFAEVDV-DGPLKLHYHEAGLSFKGTGRTV
Mflv_1464|M.gilvum_PYR-GCK MTSFAAEAAQQQEITFESTSRYAQVR---EDMRLHYHEAGV---GNPKTV
TH_1741|M.thermoresistible__bu MTSYIQEAENQVEITFESTSRYAEVKAGDRDMRLHYHEAGI---GHAQKV
MSMEG_6037|M.smegmatis_MC2_155 ------MVTATQEITFESTSRFADVQAGELAMRLHYHEAGD---PSAQTI
MLBr_01899|M.leprae_Br4923 ---------------MEVRSGYATSGD----LKLYYEDMGN---VDDPPV
: . : *.: * :
Mvan_4414|M.vanbaalenii_PYR-1 VMLHGSGPGATGWSNFGSNIKGLADRFRVIAADMPGWGQSE--AVK-PDA
MAB_3810|M.abscessus_ATCC_1997 ILLHGSGPGVTGWRNYRGNLGVFAKHFHTYVLEFPGFGVSD--AVPGHPV
Mb3600c|M.bovis_AF2122/97 VLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFN
Rv3569c|M.tuberculosis_H37Rv VLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFN
MMAR_5064|M.marinum_M VLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRAEHGQFN
MUL_4140|M.ulcerans_Agy99 VLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRAEHGQFN
MAV_0592|M.avium_104 VLLHGGGPGAASWTNFGRNIPVLARHFHVLAVDQPGYGLSDKRAEHGQFN
Mflv_1464|M.gilvum_PYR-GCK VLLHGGGPGASSWSNFGRNIPVLAKHFHVLAVDQPGYGHSDKHTEHEQYN
TH_1741|M.thermoresistible__bu VLLHGGGPGASSWSNFGRNIAVLARHFHVIAVDQPGYGHSDKHTEHEQYN
MSMEG_6037|M.smegmatis_MC2_155 VLLHGGGPGAASWSNFGRNIAVLAEHFHVLAVDQPGYGLSDKHTEHEQYN
MLBr_01899|M.leprae_Br4923 LLIMGLGAQLVLWR-TAFCEKLVAQGLRVVRYDNRDVGLSSRTDSTEQPC
::: * *. * .* ::. : . * *.
Mvan_4414|M.vanbaalenii_PYR-1 RDH------------------------VAAALQLLDGLGIE-KAAFVGNS
MAB_3810|M.abscessus_ATCC_1997 LTA------------------------GASVIRFMDGLGIS-SAAVVGNS
Mb3600c|M.bovis_AF2122/97 RYA------------------------AMALKGLFDQLGLG-RVPLVGNS
Rv3569c|M.tuberculosis_H37Rv RYA------------------------AMALKGLFDQLGLG-RVPLVGNS
MMAR_5064|M.marinum_M HYA------------------------ARALKELFDQLGLG-RVPLVGNS
MUL_4140|M.ulcerans_Agy99 HYA------------------------ARALKELFDQLGLG-RVLLVGNS
MAV_0592|M.avium_104 RYA------------------------ARALNGLFEQLELG-RVPLVGNS
Mflv_1464|M.gilvum_PYR-GCK RYS------------------------ATALLNLFDHLGIE-KAALVGNS
TH_1741|M.thermoresistible__bu RYS------------------------ATALLALFDHLGIE-RADLVGNS
MSMEG_6037|M.smegmatis_MC2_155 RYS------------------------AKAVRGLLDHLGVEGRVPLLGNS
MLBr_01899|M.leprae_Br4923 PSQPLTARLIRFWLGQRNACAYTLEDMTDDAVALLDHLSIE-RAHIVGAS
::: * : . .:* *
Mvan_4414|M.vanbaalenii_PYR-1 MGGGTAIQFAVAHPDRISHLITMGSRAPGPTIIGPDGLTEGLKTLLKGYT
MAB_3810|M.abscessus_ATCC_1997 MGGVVGINLAIKHPDRITKLVTIGG--VGPNIFSPS-PSEGLR-LLQEFT
Mb3600c|M.bovis_AF2122/97 LGGGTAVRFALDYPARAGRLVLMGPGGLSINLFAPD-PTEGVK-RLSKFS
Rv3569c|M.tuberculosis_H37Rv LGGGTAVRFALDYPARAGRLVLMGPGGLSINLFAPD-PTEGVK-RLSKFS
MMAR_5064|M.marinum_M LGGGTAVRFALDYPDRAGRLVLMGPGGLSINLFAPD-PTEGVK-RLGKFS
MUL_4140|M.ulcerans_Agy99 LGGGTAVRFALDYPDRAGRLVLMGPGGLSINLFAPD-PTEGVK-RLGKFS
MAV_0592|M.avium_104 LGGGTAVRFALDYPDKAGRLVLMGPGGLSINLFAPD-PTEGVK-RLGKFS
Mflv_1464|M.gilvum_PYR-GCK LGGGTAVRFALDNGKRAGKLVLMGPGGLSVNLFSPD-PTEGVK-LLGRFA
TH_1741|M.thermoresistible__bu LGGGTAVRFALDHPKRAGRLVLMGPGGLSVNMFAPD-PTEGVK-LLARFN
MSMEG_6037|M.smegmatis_MC2_155 LGGGTAVRFALDYPDRAGKLVLMGPGGLSVNLFAPD-PTEGVK-ALAKFN
MLBr_01899|M.leprae_Br4923 MGGMIAQIFAARFPTRTRSLAVFFSSNNRPFLPPPA-----PRALLALLT
:** . :* : * : : * : *
Mvan_4414|M.vanbaalenii_PYR-1 D-PSPTSMRELVEIMTYDSANATDELVQQRYAAAIGRPDHLENFMIAG--
MAB_3810|M.abscessus_ATCC_1997 DNPDRDKLIRWLNSMVWDPAVVTDELIEERWEAAINPDAHKTAQLMYGSK
Mb3600c|M.bovis_AF2122/97 VAPTRENLEAFLRVMVYDKNLITPELVDQRFALASTPESLTATRAMGKS-
Rv3569c|M.tuberculosis_H37Rv VAPTRENLEAFLRVMVYDKNLITPELVDQRFALASTPESLTATRAMGKS-
MMAR_5064|M.marinum_M VAPTRENLEAFLRVMVYDQKLITPELVDQRFELARTPESLAATRAMGKS-
MUL_4140|M.ulcerans_Agy99 VAPTRENLEAFLRVMVYDQKLITPELVDQRFELARTPESLAATRAMGKS-
MAV_0592|M.avium_104 AEPTRENLEAFLRVMVYDQKLITDELIDERFALASTPESLAATRAMGMS-
Mflv_1464|M.gilvum_PYR-GCK AEPTRENIEKFLRIMVFDQAMITPELVEERFQIASTPESLAATKAMGKS-
TH_1741|M.thermoresistible__bu AEPTRENLEAFLRIMVYDQSLITEELIDERFAIAATPESLAATRAMGKS-
MSMEG_6037|M.smegmatis_MC2_155 VEPTRENLEAFLRIMVFDQKLITPELVEERFAIASTPESLAATRAMGKS-
MLBr_01899|M.leprae_Br4923 GPPTGSRRDVVVDNVVRVTKITGSPLYRMPEEQVRTNAAEIYDRSFYPLG
* : :. * . :
Mvan_4414|M.vanbaalenii_PYR-1 LLGIPQATVEEIAG---------IETPTLIFHGKDDRVVSYEAALKLVSL
MAB_3810|M.abscessus_ATCC_1997 AFAMQQQFLANADIPPYWAMMHKIKCPTLLTWGRDDRVSPPDMAIVPMRL
Mb3600c|M.bovis_AF2122/97 ------FAGADFEAGMMWREVYRLRQPVLLIWGREDRVNPLDGALVALKT
Rv3569c|M.tuberculosis_H37Rv ------FAGADFEAGMMWREVYRLRQPVLLIWGREDRVNPLDGALVALKT
MMAR_5064|M.marinum_M ------FAAADFELGMMWREVYKLRQPVLLIWGREDRVNPLDGALVALKT
MUL_4140|M.ulcerans_Agy99 ------FAAADFELGMMWREVYKLRQPVLLIWGREDRVNPLDGALVALKT
MAV_0592|M.avium_104 ------FAGADFELGMMWREVHRLRQPVLLIWGREDRVNPLDGALVALKT
Mflv_1464|M.gilvum_PYR-GCK ------FAGADFELGMMWRDVYKLRQRVLLIWGREDRVNPLDGALVALKQ
TH_1741|M.thermoresistible__bu ------FMGPDFELGMMWRDAYKLRQRVLLIWGREDRVNPLDGALVALKQ
MSMEG_6037|M.smegmatis_MC2_155 ------FAGADFELGMMWREVYKLRQPVLLIWGREDRVNPLDGALVAVKQ
MLBr_01899|M.leprae_Br4923 ---VSRQFSAILGSGSLLHYNQRIIAPTVVIHGRADKLVRPSSGRAVARA
: .:: *: *:: . .
Mvan_4414|M.vanbaalenii_PYR-1 IRDSRVVLINRCGHWLQTEHSDEFNRLVADFVSNR------
MAB_3810|M.abscessus_ATCC_1997 IPNAELHIFPNSGHWVMIEAKQAFEQTVVDFLRR-------
Mb3600c|M.bovis_AF2122/97 IPRAQLHVFGQCGHWVQVEKFDEFNKLTIEFLGGGR-----
Rv3569c|M.tuberculosis_H37Rv IPRAQLHVFGQCGHWVQVEKFDEFNKLTIEFLGGGR-----
MMAR_5064|M.marinum_M IPRAQLHVFGQCGHWAQVEKFDEFNRLTIDFLGGAR-----
MUL_4140|M.ulcerans_Agy99 IPRAQLHVFGQCGHWAQVEKFDEFNRLTIDFLGGAR-----
MAV_0592|M.avium_104 IARAQLHVFGQCGHWAQVEKFDEFNKLTIDFLGGA------
Mflv_1464|M.gilvum_PYR-GCK IPRVQLHVFGQCGHWAQLEKFDEFNKLTIDFLTN-------
TH_1741|M.thermoresistible__bu IPRVQLHVFGQCGHWAQVEKFDEFNRLTIDFLEDGAKEAKS
MSMEG_6037|M.smegmatis_MC2_155 IPRVQLHVFGQCGHWAQVEKFDEFNKLTIDFLGG-------
MLBr_01899|M.leprae_Br4923 ITGARLVLFDGMGHDLPQQLWDQAVGVLMSNFAKAS-----
* .: :: ** : : . .