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VLNRFDVAVVGGGTAGCAVAARLAGSGRKVLVLEAGPDYGHALSGRWPADLLSAATIPSSHDWGYRGTGA GGQHLEFERCRVIGGCSTHNGATQNVGWGGDYDRWAATGLTGWSSSELEPFFELAGKALNLRNYRDEQLQ PLQTAFVAAVVDQGLEERNDFLSMNGSAGVGYSPVSITDDGTRYNTAFAYLDDLRESGRLTVLGGVEVTG IRLEQGRAVGVYVYAPDRTAPEPALVYADTVVLSAGAYGTPELLLRSGIGPAGELAGVGVPVQCDLPGVG KGLQDHPSLQLEYAATRELADALAEFMSRQWLPDEQAIAKVKSPEAGDAPFDLHIYPWTERDPASPHGWR CVVPIGLVKPRSRGALTLRLVGGELKTEVNHGYLADPRDVNAMRYGMEWAEEIIDTGISEFSRYLGPRIN PMEGLTTDWIAANHRHYWHPVGTCTMGMPATGGVVDHRGAVHGIDNLYIADASVFPDIPRGTTALPTTVV GERIASFLMEDN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0816 | - | - | 100% (502) | glucose-methanol-choline oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0250 | - | 5e-37 | 29.16% (535) | GMC-type oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3830c | - | 2e-32 | 27.68% (513) | dehydrogenase (glucose-methanol-choline oxidoreductase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 3e-36 | 29.72% (535) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3085 | - | 2e-44 | 28.98% (521) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 4e-36 | 29.72% (535) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4141 | - | 2e-41 | 30.47% (535) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. avium 104 | MAV_4980 | - | 2e-41 | 30.94% (446) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5305 | - | 4e-41 | 30.27% (522) | choline dehydrogenase |
| M. thermoresistible (build 8) | TH_3275 | - | 3e-39 | 29.66% (563) | PUTATIVE putative oxidoreductase, GMC family protein |
| M. ulcerans Agy99 | MUL_4004 | - | 7e-42 | 30.65% (535) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1300 | - | 1e-36 | 29.17% (528) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4980|M.avium_104 ------------------MQTAIGRAVPFARGRG----------------
MSMEG_5305|M.smegmatis_MC2_155 ----------MSYDVIVVGGGTSGRVVAARLSEDPEIEVLLLEKDAS---
Mflv_3085|M.gilvum_PYR-GCK ------MADAGVFDYVIAGGGTAGCVLAARLSEDPDVTVCLLEAGPSDVG
Mb1310|M.bovis_AF2122/97 --------MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRD-K
Rv1279|M.tuberculosis_H37Rv --------MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRD-K
MMAR_4141|M.marinum_M --------MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSD-K
MUL_4004|M.ulcerans_Agy99 --------MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSD-K
TH_3275|M.thermoresistible__bu MGVVMMGRRSNLHDYIVVGAGSSGCTVAGRLAEGKRHSVLVLEAGGSD-L
MAB_0816|M.abscessus_ATCC_1997 --------MLNRFDVAVVGGGTAGCAVAARLAGSGR-KVLVLEAGPDYGH
Mvan_1300|M.vanbaalenii_PYR-1 ----------MRSDVLIVGAGSAGSVLAERLSADDGCQVTVVEAGPGPFD
: * .: . .
MAV_4980|M.avium_104 --------------------------------------------IGGSST
MSMEG_5305|M.smegmatis_MC2_155 ---------------------VPGMPPR----------------AGGSSA
Mflv_3085|M.gilvum_PYR-GCK DDAILVLSDWMRLLDSGYDWDYPIEPQE----------------RGNSFM
Mb1310|M.bovis_AF2122/97 NRFIGVPAAFSKLFRSEIDWDYLTEPQPELD--GREIYWPRGKVLGGSSS
Rv1279|M.tuberculosis_H37Rv NRFIGVPAAFSKLFRSEIDWDYLTEPQPELD--GREIYWPRGKVLGGSSS
MMAR_4141|M.marinum_M NRFIGIPAAFPKLFRSEVDWDYTTEPEPQLG--GREIYWPRGKVLGGSSS
MUL_4004|M.ulcerans_Agy99 NRFIGIPAAFPKLFRSEVDWDYTTEPEPQLG--GREIYWPRDKVLGGSSS
TH_3275|M.thermoresistible__bu SPFIRIPAGLMR-VNPRNYWHFRLEPDPTRN--GAVDTWAAGRVVGGGSS
MAB_0816|M.abscessus_ATCC_1997 ALSGRWPADLLSAATIPSSHDWGYRGTG-AG--GQHLEFERCRVIGGCST
Mvan_1300|M.vanbaalenii_PYR-1 PRVGTQITDGLRLPIGVASSVVRRYPTALTDEPRRHAQIMRGAVVGGSGA
*.
MAV_4980|M.avium_104 INAMVFARGHRDSYSRWRDNGAAGWSFDELLPYFKRSESTCGKDPSLRGQ
MSMEG_5305|M.smegmatis_MC2_155 TDATVFARGHHASYTDWNQFGGYGWGFADLLPYFMRSETATHGDPALRGD
Mflv_3085|M.gilvum_PYR-GCK RHARAKVLGGCSSHNSCIAFHPPAEALDEWAAMGATGWSAAEVLPLVQRL
Mb1310|M.bovis_AF2122/97 MNAMMWVRGFASDYDEWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGD
Rv1279|M.tuberculosis_H37Rv MNAMMWVRGFASDYDEWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGD
MMAR_4141|M.marinum_M MNAMMWVRGFAADYDEWARLAGSHWSYGELLGYFRQIEDVTAAWHFVNGD
MUL_4004|M.ulcerans_Agy99 MNAMMWVRGFAADYDEWARLAGSHWSYGELLGYFRQIEDVTAAWHFVNGD
TH_3275|M.thermoresistible__bu VNAMLWVRGNRADFDTWAKLGAQGWDYESLLPAMRSLETWEGGADRYRGG
MAB_0816|M.abscessus_ATCC_1997 HNGATQNVGWGGDYDRWAATGLTGWSSSELEPFFELAGKALN--------
Mvan_1300|M.vanbaalenii_PYR-1 VNGGYFCRALPSDFDGWG---IAGWSWDEVLPHYTAIETDLDFTGPLHGS
.. . .. .
MAV_4980|M.avium_104 ----DGPMAVAPAAHPNPVLVACLCAAIQQGYPRAADISG-----GLEVG
MSMEG_5305|M.smegmatis_MC2_155 ----RGPLLVGPADRLSPLMLAFRRAAVERGFSAADDISG-----GLETG
Mflv_3085|M.gilvum_PYR-GCK ----TETVRLRDVPPDDPCGAAVLEAAARIGIPTVSFNRGQ----TVRNG
Mb1310|M.bovis_AF2122/97 DSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSP------RPEG
Rv1279|M.tuberculosis_H37Rv DSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSP------RPEG
MMAR_4141|M.marinum_M DSGVTGPLQISRQRSPSPLTAAWLAATRDCGFPPVQPNSA------EPEG
MUL_4004|M.ulcerans_Agy99 DSGVTGPLQISRQRSPSPLTAAWLAATRDCGFAPVQPNSA------EPEG
TH_3275|M.thermoresistible__bu ----TGPQHVSRIRLHHPLVQKWLTGAAQTGMPILADYNG-----ESQFG
MAB_0816|M.abscessus_ATCC_1997 -------LRNYRDEQLQPLQTAFVAAVVDQGLEERNDFLSM----NGSAG
Mvan_1300|M.vanbaalenii_PYR-1 ----AGPISVRRVSEFDGCTASFVESAREAGFGWIEDLNGSTPERPLPAG
.. * *
MAV_4980|M.avium_104 FGFTDLNI-VDGKRQSAADAYLLPALD-RPNLEFHSGATVHRLRIRGS-R
MSMEG_5305|M.smegmatis_MC2_155 FGPVDL---VDGPRESAADPYLAPALG-RDNLTVITAATVQRVLMDRN-R
Mflv_3085|M.gilvum_PYR-GCK AGWFQINATPEGARLSTSHAFLHPILGTRRNLEVRTDSWVSEILFDDASR
Mb1310|M.bovis_AF2122/97 FCETVVTQ-RRGARFSTADAYLKPAMR-RKNLRVLTGATATRVVIDGD-R
Rv1279|M.tuberculosis_H37Rv FCETVVTQ-RRGARFSTADAYLKPAMR-RKNLRVLTGATATRVVIDGD-R
MMAR_4141|M.marinum_M FCETIVTQ-RRGSRWSTVDAYLRPAMG-RRNLSILTGATATRIVIHGT-R
MUL_4004|M.ulcerans_Agy99 FCETIVTQ-RRGSRWSTVDAYLRPAMG-RRNLSILTGATATRIVIHGT-R
TH_3275|M.thermoresistible__bu AAWSQLSQ-KNGLRHSAAQAFLAPARR-RGEVDVESHAVVDKVIIENG-R
MAB_0816|M.abscessus_ATCC_1997 VGYSPVSITDDGTRYNTAFAYLDDLRE-SGRLTVLGGVEVTGIRLEQG-R
Mvan_1300|M.vanbaalenii_PYR-1 VGAVPLNI-NGGTRVGPGGAFLQPALQ-RANLTLVTDTRVGGLRFSAG-R
: * * .. .:* .: . . : : *
MAV_4980|M.avium_104 CTGVEYTTAEGR---QVTAAAREIILCAGAIGSPHLLLASGIGPPNHLRS
MSMEG_5305|M.smegmatis_MC2_155 AVGVEYRCNSKL---VTVTAAREVVLAAGAVCSPQLLMLSGIGPARHLRE
Mflv_3085|M.gilvum_PYR-GCK ATGVRYQRADLTG-YDTVAARREVILTAGAIDTPKLLMLSGIGPTAHLRE
Mb1310|M.bovis_AF2122/97 AVGVEYQSDGQT---RIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAE
Rv1279|M.tuberculosis_H37Rv AVGVEYQSDGQT---RIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAE
MMAR_4141|M.marinum_M ATGIEYQREGQH---CTVHARREVVLCGGAVNSPQLLMLSGIGDRSHLAD
MUL_4004|M.ulcerans_Agy99 ATGVEYQREGQH---CTVHARREVVLCGGAVNSPQLLMLSGIGDRSHLAD
TH_3275|M.thermoresistible__bu AVGVEYVRRGTR---KVAYAAKEVILSAGALCSPLILLRSGIGPAEELRD
MAB_0816|M.abscessus_ATCC_1997 AVGVYVYAPDRTAPEPALVYADTVVLSAGAYGTPELLLRSGIGPAGELAG
Mvan_1300|M.vanbaalenii_PYR-1 VVGVDCLGPGGP----TTLVADRVVLCAGAIASAQLLMVSGVGPQQVLRA
.*: ::* .** :. :*: **:* *
MAV_4980|M.avium_104 FRVDVALELPGVGANLQDHPIVPLVYRAARPVPAGRYNHGELLG-----L
MSMEG_5305|M.smegmatis_MC2_155 LDADVLVDLPGIGANLQNHPLAGIVYLAAQPLPVSDH-RAEMMG-----L
Mflv_3085|M.gilvum_PYR-GCK VGIDVRVDSPGVGANLDDHVEGLVFWEASRPMVTASTQWWEIGL-----F
Mb1310|M.bovis_AF2122/97 HDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQLIS-----Y
Rv1279|M.tuberculosis_H37Rv HDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQLIS-----Y
MMAR_4141|M.marinum_M HGIETVYHAPEVGQNLLDHLITPLGFDVAGDSLAAAEKPMQLIN-----Y
MUL_4004|M.ulcerans_Agy99 HGIETVYHAPEVGQNLLDHLITPLGFDVAGDSLAAAEKPMQLIN-----Y
TH_3275|M.thermoresistible__bu HGIDVIADLPGVGRNLQEHPAITMTFTVTDRTLNQELTPLSILKGAFDFV
MAB_0816|M.abscessus_ATCC_1997 VGVPVQCDLPGVGKGLQDHPSLQLEYAATRELADALAEFMSRQWLP----
Mvan_1300|M.vanbaalenii_PYR-1 AGVAVQIDLP-VGVDTVDHPEWVLPVTWPPTHGVPPLEAVLTTG------
. . * :* . :* :
MAV_4980|M.avium_104 IR---------RHAT----GGPPE-------IQIFGVDS--------ADV
MSMEG_5305|M.smegmatis_MC2_155 LH---------TGSP----GGAPD-------LQIRCTDT--------AGA
Mflv_3085|M.gilvum_PYR-GCK TT---------VDEIPEGVRAQPD-------LMMHYGSVPFD---MNTLR
Mb1310|M.bovis_AF2122/97 LLRRRGMLTSNVGEAYGFVRSRPE-------LKLPDLELIFAPAPFYDEA
Rv1279|M.tuberculosis_H37Rv LLRRRGMLTSNVGEAYGFVRSRPE-------LKLPDLELIFAPAPFYDEA
MMAR_4141|M.marinum_M LLRRRGMLTSNVGEAYGFVRSRPG-------LDLPDLELIFAPAPFYDEG
MUL_4004|M.ulcerans_Agy99 LLRRRGMLTSNVGEAYGFVRSRPG-------LDLPDLELIFAPAPFYDEG
TH_3275|M.thermoresistible__bu LRRRGPATAPLSHAMLFGPPLEPEGWPQYHVLMAPLGTEQEKPHATQEEA
MAB_0816|M.abscessus_ATCC_1997 ------------DEQAIAKVKSPE----------AGDAPFDLHIYPWTER
Mvan_1300|M.vanbaalenii_PYR-1 -----------DGLEIRPYTAGFG----------------------AMMT
MAV_4980|M.avium_104 PG-LGGADGYVLG--------VSVMQPVSRGRVGLSGPTIQEPPAIDPNY
MSMEG_5305|M.smegmatis_MC2_155 TGAVFGVETCFIG--------VSPMHPHSRGTVRLAGLTAEVPPVVNPHH
Mflv_3085|M.gilvum_PYR-GCK HGYPTTDNGFCLT--------PNVTQGRSRGTVRLRSRDFRDRARVDPRY
Mb1310|M.bovis_AF2122/97 LVP-PAGHGVVFG--------PILVAPQSRGQITLRSADPHAKPVIEPRY
Rv1279|M.tuberculosis_H37Rv LVP-PAGHGVVFG--------PILVAPQSRGQITLRSADPHAKPVIEPRY
MMAR_4141|M.marinum_M LPAHPPGHGVVFG--------PILVAPQSRGQITLRSADPHAKPIIEARY
MUL_4004|M.ulcerans_Agy99 LPAHPPGHGVVFG--------PILVAPQSRGQITLRSADPHAKPIIEARY
TH_3275|M.thermoresistible__bu EQNRYDKQNVSLSRNSIVSAFMSPLHPRGRGTVRLGSPDVDATPVIEHPM
MAB_0816|M.abscessus_ATCC_1997 DPASPHGWRCVVP--------IGLVKPRSRGALTLRLVGGELKTEVNHGY
Mvan_1300|M.vanbaalenii_PYR-1 GRRDDPTDQPHLG--------VTLMQPLSRGRVTITSADPDADPVIEHRY
. .** : : . ::
MAV_4980|M.avium_104 LSD--DRDMGLMIEGLRIGRKIGMS--QALDPWRAEELAP-GDDAVDDAA
MSMEG_5305|M.smegmatis_MC2_155 LED--ERDMKTMLDGLDVARQIGAS--PELRPWLAEELAP-GAHITDEDR
Mflv_3085|M.gilvum_PYR-GCK FTDPDSYDERIMLAGIKLARAIAAQ--APLTPWVARELAP-GPDATTDDE
Mb1310|M.bovis_AF2122/97 LSDLGGVDRAAMMAGLRICARIAQA--RPLRDLLGSIARPRNSTELDEAT
Rv1279|M.tuberculosis_H37Rv LSDLGGVDRAAMMAGLRICARIAQA--RPLRDLLGSIARPRNSTELDEAT
MMAR_4141|M.marinum_M LSDPGGVDRAAMMEGLRICARIAQA--PALRGLLGPVARPHNSSELDEAT
MUL_4004|M.ulcerans_Agy99 LSDPGGVDRAAMMEGLRICARIAQA--PALRGLLGPVARPHNSSELDEAT
TH_3275|M.thermoresistible__bu LAD--ERDVVDLTAAGRKVREIFQS--PAMRPHVIAENAP-SRGVETDDE
MAB_0816|M.abscessus_ATCC_1997 LAD--PRDVNAMRYGMEWAEEIIDTGISEFSRYLGPRINP------MEGL
Mvan_1300|M.vanbaalenii_PYR-1 DSE--PADVELLRAGTRLAHELAGA-------------------------
: * : . :
MAV_4980|M.avium_104 LRSYIQRSVASYFHPVGTCAMGT--GPESVVDNQLRLHGIDNLRVIDASV
MSMEG_5305|M.smegmatis_MC2_155 LREYIRTTGGNWFHPVGTCALGE--SKMSVVDSRLRVRGTDGLRVIDASV
Mflv_3085|M.gilvum_PYR-GCK LLDYIHRCHNTVYHPAATARMGSPSDPMAVLDPQLRVKGVRGLRVVDASA
Mb1310|M.bovis_AF2122/97 LELALATCSHTLYHPMGTCRMGS--DEASVVDPQLRVRGVDGLRVADASV
Rv1279|M.tuberculosis_H37Rv LELALATCSHTLYHPMGTCRMGS--DEASVVDPQLRVRGVDGLRVADASV
MMAR_4141|M.marinum_M LELALTTCSHTLYHPLGTCRMGS--DEASVVDPQLRVRGVDGLRVADASV
MUL_4004|M.ulcerans_Agy99 LELALTTCSHTLYHPLGTCRMGS--DEASVVDRQLRVRGVDGLRVADASV
TH_3275|M.thermoresistible__bu WAEFIRNHCFGGSHWVGTARMGADSDPDAVVDPQLRVRGVSGLRVADASV
MAB_0816|M.abscessus_ATCC_1997 TTDWIAANHRHYWHPVGTCTMGMP-ATGGVVDHRGAVHGIDNLYIADASV
Mvan_1300|M.vanbaalenii_PYR-1 -TVQSEASWATSQHLCGTARMGA------VVDARCRVYGVSNLWVVDGSI
* .*. :* *:* : : * .* : *.*
MAV_4980|M.avium_104 MPSLPSNNTAATVYAIAERGADLVRLG-------
MSMEG_5305|M.smegmatis_MC2_155 MPSLPSNNIVATVYAIAERSAEMVRDELAQRHW-
Mflv_3085|M.gilvum_PYR-GCK MPKLPAVNPNITVMTMAEKCAELIRTG-------
Mb1310|M.bovis_AF2122/97 MPSTVRGHTHAPSVLIGEKAADLIRS--------
Rv1279|M.tuberculosis_H37Rv MPSTVRGHTHAPSVLIGEKAADLIRS--------
MMAR_4141|M.marinum_M MPSTVRGHTHAPSVLIGAKAADLIRN--------
MUL_4004|M.ulcerans_Agy99 MPSTVRGHTHAPSVLIGAKAADLIRN--------
TH_3275|M.thermoresistible__bu MPTLTSGNTNAPCVLIGEKAAELIRGR-------
MAB_0816|M.abscessus_ATCC_1997 FPDIPRGTTALPTTVVGERIASFLMEDN------
Mvan_1300|M.vanbaalenii_PYR-1 LPAIPSRGPHATIVMAGHRAAEFVSATSTERAGA
:* . . : *.::