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M. thermoresistible (build 8) TH_4559 (-)

annotation: putative acyl-CoA dehydrogenase
coordinates: 1024102 - 1025250
length: 383

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4559--100% (383)putative acyl-CoA dehydrogenase
M. thermoresistible (build 8)TH_2026-0.084.82% (382) transposase
M. thermoresistible (build 8)TH_3989-e-10955.53% (371) PUTATIVE acyl-CoA dehydrogenase domain protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3604cfadE347e-4233.59% (387) acyl-CoA dehydrogenase FADE34
M. gilvum PYR-GCKMflv_5166-1e-10553.03% (379) Fis family transcriptional regulator
M. tuberculosis H37RvRv3573cfadE347e-4233.59% (387) acyl-CoA dehydrogenase FADE34
M. leprae Br4923MLBr_00737fadE254e-2526.80% (388) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977MAB_0597-3e-4032.91% (395) acyl-CoA dehydrogenase FadE
M. marinum MMMAR_3511-1e-11155.88% (374) acyl-CoA dehydrogenase
M. avium 104MAV_1814-1e-17376.18% (382) putative acyl-CoA dehydrogenase
M. smegmatis MC2 155MSMEG_2879-1e-11255.67% (379) acyl-CoA dehydrogenase
M. ulcerans Agy99MUL_2757-1e-11154.71% (382) acyl-CoA dehydrogenase
M. vanbaalenii PYR-1Mvan_2876-1e-11155.65% (372) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb3604c|M.bovis_AF2122/97           MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRP
Rv3573c|M.tuberculosis_H37Rv        MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRP
TH_4559|M.thermoresistible__bu      --------------------------------------------------
MAV_1814|M.avium_104                --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_2876|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3511|M.marinum_M               --------------------------------------------------
MUL_2757|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK          --------------------------------------------------
MAB_0597|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_00737|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3604c|M.bovis_AF2122/97           VFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAV
Rv3573c|M.tuberculosis_H37Rv        VFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAV
TH_4559|M.thermoresistible__bu      --------------------------------------------------
MAV_1814|M.avium_104                --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_2876|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3511|M.marinum_M               --------------------------------------------------
MUL_2757|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK          --------------------------------------------------
MAB_0597|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_00737|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3604c|M.bovis_AF2122/97           ATLVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAP
Rv3573c|M.tuberculosis_H37Rv        ATLVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAP
TH_4559|M.thermoresistible__bu      --------------------------------------------------
MAV_1814|M.avium_104                --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_2876|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3511|M.marinum_M               --------------------------------------------------
MUL_2757|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK          --------------------------------------------------
MAB_0597|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_00737|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3604c|M.bovis_AF2122/97           GGVVLLPADGNWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLE
Rv3573c|M.tuberculosis_H37Rv        GGVVLLPADGNWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLE
TH_4559|M.thermoresistible__bu      --------------------------------------------------
MAV_1814|M.avium_104                --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_2876|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3511|M.marinum_M               --------------------------------------------------
MUL_2757|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK          --------------------------------------------------
MAB_0597|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_00737|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3604c|M.bovis_AF2122/97           VSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAVK
Rv3573c|M.tuberculosis_H37Rv        VSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAVK
TH_4559|M.thermoresistible__bu      --------------------------------------------------
MAV_1814|M.avium_104                --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_2876|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3511|M.marinum_M               --------------------------------------------------
MUL_2757|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK          --------------------------------------------------
MAB_0597|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_00737|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3604c|M.bovis_AF2122/97           HLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKAN
Rv3573c|M.tuberculosis_H37Rv        HLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKAN
TH_4559|M.thermoresistible__bu      --------------------------------------------------
MAV_1814|M.avium_104                --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_2876|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_3511|M.marinum_M               --------------------------------------------------
MUL_2757|M.ulcerans_Agy99           --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK          --------------------------------------------------
MAB_0597|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_00737|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb3604c|M.bovis_AF2122/97           AKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALTQAG
Rv3573c|M.tuberculosis_H37Rv        AKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALTQAG
TH_4559|M.thermoresistible__bu      --------------------------VSQFDALRANE----PELADLRAS
MAV_1814|M.avium_104                --------------------------MSSFDALIARE----PELAELRSA
MSMEG_2879|M.smegmatis_MC2_155      --------------------------MAIPRLVPALD-TEPADATALRAE
Mvan_2876|M.vanbaalenii_PYR-1       --------------------------MARTRLVPPAG-VDHADTARLRAD
MMAR_3511|M.marinum_M               ---------------------MADALMALPRLVPPAGALDSPRADVLRGE
MUL_2757|M.ulcerans_Agy99           --------------------------MALPRLVPPAGALDSPRADVLRGE
Mflv_5166|M.gilvum_PYR-GCK          --------------------------MNTSRLVPPVA-DDPHAMDGLRDE
MAB_0597|M.abscessus_ATCC_1997      ------------------------MVESQVSPAPAGEPMSEMSDDQVRTE
MLBr_00737|M.leprae_Br4923          -------------------------MVGWSGNPLFDLFKLPEEHNELRAT
                                                                                   :  

Mb3604c|M.bovis_AF2122/97           VRRRLGVDLA-EVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAPHWP
Rv3573c|M.tuberculosis_H37Rv        VRRRLGVDLA-EVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAPHWP
TH_4559|M.thermoresistible__bu      VREFLERDRA-EFG-----WEPDVDSWLGQWDEGFSARLAAAGYVGMTIP
MAV_1814|M.avium_104                IRDFLRADRA-EFG-----WMPAVDAWLGQWDEGFSARLGAAGFLGLTVP
MSMEG_2879|M.smegmatis_MC2_155      VRAFLDEQRA-AGT-----FTPAVDAWLCGWDEKFTTALAARGWLGMTVP
Mvan_2876|M.vanbaalenii_PYR-1       VRAFLAEQLA-AQT-----FVPSVDSWLCGWDEAFTEALAARGYLGMTVP
MMAR_3511|M.marinum_M               VRAFLAEQSA-AGG-----FTPSVDAWLSAWDEDFTAALADRGWLGMTVP
MUL_2757|M.ulcerans_Agy99           VRAFLAEQSA-AGG-----FTPSVDAWLSAWDEDFTAALADRGWLGMTVP
Mflv_5166|M.gilvum_PYR-GCK          VRQFVAEQRD-AGR-----IGRQVDSWLTGWDEDFSRALAARGWLGMTVP
MAB_0597|M.abscessus_ATCC_1997      IREWLAENLVGEFAELKGLGGPGSEHEAFEERLAWNRHLAAAGWTCLGWP
MLBr_00737|M.leprae_Br4923          IRALAEKEIA---------PHAADVDQRARFPEEALAALNASGFNAIHVP
                                    :*     :                              *   *      *

Mb3604c|M.bovis_AF2122/97           APYG-RGASPAEQLLIDQELAAAKVERPDLVIG-WWAAPTILEHGTPEQI
Rv3573c|M.tuberculosis_H37Rv        APYG-RGASPAEQLLIDQELAAAKVERPDLVIG-WWAAPTILEHGTPEQI
TH_4559|M.thermoresistible__bu      KEYGGHGLTHLHRYVVTEELLAQGAPVAAHWVADRQVVPGLLAYGTEEQR
MAV_1814|M.avium_104                KRYGGHGLGHLHRYVVTEELIASGAPVAAHWTADRQVAPGLLSYGSEEQC
MSMEG_2879|M.smegmatis_MC2_155      KEYGGQGRSFLHRFVVTEELLAAGVPVAAHWIADRQIVPSLLKYGTERQK
Mvan_2876|M.vanbaalenii_PYR-1       EEYGGHGRSHIERFVVTEELLAAGAPVAAHWIADRQIVPALLKHGTDAQK
MMAR_3511|M.marinum_M               VEYGGHGRTFLERFVVTEELLAAGAPVAAHWIADRQIVPSLLKYGTELQK
MUL_2757|M.ulcerans_Agy99           VEYGGHGRTFLERFVVTEELLAVGAPVAAHWIADRQIVPSLLKYGTELQK
Mflv_5166|M.gilvum_PYR-GCK          EEYGGHGRSFLERFVVTEELLAAGAPVGAHWIADRQIVPSLLKYGTETQK
MAB_0597|M.abscessus_ATCC_1997      VEHGGRGATVSQRVIFYEEYARAEAPHKVNHLGEELLGPTLIAYGTPEQQ
MLBr_00737|M.leprae_Br4923          EEYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELK
                                      :* :*       :. :*     .               ::  *:    

Mb3604c|M.bovis_AF2122/97           ERFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVWT
Rv3573c|M.tuberculosis_H37Rv        ERFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVWT
TH_4559|M.thermoresistible__bu      QRLLPRIAAGKFFSSIGMSEHGAGSDLAAVQTKAVRTDGGWVLNGTKVWT
MAV_1814|M.avium_104                ERLLPKIVAGKLYSSIGMSEHGAGSDLAAVSTKAVRAEGGWVLSGTKVWT
MSMEG_2879|M.smegmatis_MC2_155      QEFLPRIAAGQCFFGIGMSEPDSGSDLASVRTRAVQVEGGWRLTGTKVWT
Mvan_2876|M.vanbaalenii_PYR-1       REFLPKIAAGKCFFGIGMSEPDSGSDLASVRTRATRTDGGWSLSGTKVWT
MMAR_3511|M.marinum_M               SHFLPRIVRGECFFGIGMSEPDSGSDLASVRTRAVRGEGGWLLSGTKVWT
MUL_2757|M.ulcerans_Agy99           SHFLPRIVRGECFFGIGMSEPDSGSDLASVRTRAVRGEGGWLLSGTKVWT
Mflv_5166|M.gilvum_PYR-GCK          RRYLPEIAAGRCYFGIGMSEPDSGSDLASVRTKASPVDGGWSVTGAKVWT
MAB_0597|M.abscessus_ATCC_1997      QRFLPAIRDVTELWCQGYSEPGAGSDLANVSTSAVLDGGDWVINGQKVWT
MLBr_00737|M.leprae_Br4923          KQVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCWI
                                     . :*             **  :*** * : * *    ..* :.* * * 

Mb3604c|M.bovis_AF2122/97           SAAHKARWGVCLARTDPDAP--KHKGITYFLVDMTTPGIEIRPLREITGD
Rv3573c|M.tuberculosis_H37Rv        SAAHKARWGVCLARTDPDAP--KHKGITYFLVDMTTPGIEIRPLREITGD
TH_4559|M.thermoresistible__bu      SGAHKAHQVVVLARTSPPDPQKRHAGFSQFLVPCDAKGVRIEPILLMNGD
MAV_1814|M.avium_104                SGAHRAHQVVVLARTSPPDPHNRHNGFSQFLVPCDAKGVRVEPILLMSGA
MSMEG_2879|M.smegmatis_MC2_155      SGAHRAHAFIVLARTAPVDPAHRHAGLSQFIVRFDGPGVEVRPIISMNGG
Mvan_2876|M.vanbaalenii_PYR-1       SGAHRAHAFIVLARTAPADPAHRHDGLSQFIVRFDGPGVEVRPIVSMNGG
MMAR_3511|M.marinum_M               SGAHRAHAFIVLARTAPVDPDHRHAGLSQFIVDLRGPGVQTRPIISMNGA
MUL_2757|M.ulcerans_Agy99           SGAHRAHAFIVLARTAPVDPDHRHAGLSQFIVDLRGPGVQTRPIISMNGA
Mflv_5166|M.gilvum_PYR-GCK          SGAHRADAFICLARTEPVDPAHRHAGLSQFIVDLRSPGVDIRPIVSMDGR
MAB_0597|M.abscessus_ATCC_1997      SLALQSQWCFVVARTEPGSS--RHKGLSYLLVPLDQPGVEIRPIIQLTGT
MLBr_00737|M.leprae_Br4923          TNGGKSTWYTVMAVTDPDKG---ANGISAFIVHKDDEGFSIGPKEKKLGI
                                    : . ::     :* * *        *:: ::*     *.   *     * 

Mb3604c|M.bovis_AF2122/97           --SLFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANER--VAMATG---
Rv3573c|M.tuberculosis_H37Rv        --SLFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANER--VAMATG---
TH_4559|M.thermoresistible__bu      --HHFNEVSFEDVFIPDADVLGEIGNGWHQVTAELSFER--SGPERI---
MAV_1814|M.avium_104                --HHFNEVILDSVFVADGDVLGEVGNGWQQVTSELSFER--SGPERI---
MSMEG_2879|M.smegmatis_MC2_155      --HHFNEVILDDAFVPDDMVFGQIGNGWQQVTSELSFER--SGPERL---
Mvan_2876|M.vanbaalenii_PYR-1       --HHFNEVILDGAFVPEDMVFGEIGDGWSQVTSELSFER--SGPERL---
MMAR_3511|M.marinum_M               --HHFNEVILDNACVPDEMVFGAIGNGWTQVTSELSFER--SGPERF---
MUL_2757|M.ulcerans_Agy99           --HHFNEVILDNAHVPDEMVFGAIGNGWTQVTSELSFER--SGPERF---
Mflv_5166|M.gilvum_PYR-GCK          --HHFNEVLLDDVFVADDMVFGAIGDGWQQVTSELAFER--SGPERF---
MAB_0597|M.abscessus_ATCC_1997      --SEFNEVFFDNARTSADLVVGEPGDGWRVAMGTLTFERGVSTLGNQ---
MLBr_00737|M.leprae_Br4923          KGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIA
                                         .*: ::    .   :.*  . *:  .   *   *           

Mb3604c|M.bovis_AF2122/97           ---TALGNPMEELLKVLGDMELDVAQQDR-LGRLILLAQAGALLDRRIAE
Rv3573c|M.tuberculosis_H37Rv        ---TALGNPMEELLKVLGDMELDVAQQDR-LGRLILLAQAGALLDRRIAE
TH_4559|M.thermoresistible__bu      ---LSTVPLIVAAIRLLGNTPGTDDTTARIVGDLLGRLISLRQLSVWVAR
MAV_1814|M.avium_104                ---LSTGPLLLAAIRALSNGPAPDERTATVVGDLLARLISLRQLSLSVAR
MSMEG_2879|M.smegmatis_MC2_155      ---LSTFVLLAQTTDSMARQQISRDAD---LGRLVARIAGLHHMSMAVAG
Mvan_2876|M.vanbaalenii_PYR-1       ---LSTFPLLAATAESMAQHRISYDAA---LGRMVARVAGLHQMSTAVAG
MMAR_3511|M.marinum_M               ---LSTFVLLAATAESMAEQRFTRDQQ---LGRLVARIAGLHQMSAAVAG
MUL_2757|M.ulcerans_Agy99           ---LSTFVLLAATAESMAEQRFTRDQQ---LGRLVARIAGLHQMSAAVAG
Mflv_5166|M.gilvum_PYR-GCK          ---LSTFPLLAELAALMNDG-LPRHND---LGRYVARVAGLHQMSTAVAG
MAB_0597|M.abscessus_ATCC_1997      ---ITYARELSRLAELAKSNGAADDPAIR--ERLAQAYVGMRTMRAYALA
MLBr_00737|M.leprae_Br4923          QGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAA
                                                                           .   :      

Mb3604c|M.bovis_AF2122/97           LAVGG-QDPGAQSSVRKLIGVRYRQALAEYLMEVSDGG------------
Rv3573c|M.tuberculosis_H37Rv        LAVGG-QDPGAQSSVRKLIGVRYRQALAEYLMEVSDGG------------
TH_4559|M.thermoresistible__bu      TLSEH-KDAANQAALVKDLGTRFEQDSIEVIADVLDRV----------SP
MAV_1814|M.avium_104                TLTEG-GDAANLAALVKDLGTRFEAESVEVVADLLEWS----------TP
MSMEG_2879|M.smegmatis_MC2_155      ALERH-EPADVPAAVVKVLGTTTEGD-IADFADLHRGD--------DGAL
Mvan_2876|M.vanbaalenii_PYR-1       ALERD-EPADVPAAVVKLLGTSTEGD-IADFADLHTGD--------ETTT
MMAR_3511|M.marinum_M               ALERN-DPADLPAAVVKVLGTSTEGD-IAELADLADS---------HRPR
MUL_2757|M.ulcerans_Agy99           ALERN-DPADLPAAVVKVLGTSTESD-IAELADLADSTDLADSGAPHRPR
Mflv_5166|M.gilvum_PYR-GCK          ALERH-EPADTAAAVVKVLGTSTEGD-IADFADLLTDA--------CAPD
MAB_0597|M.abscessus_ATCC_1997      TMDEE-RPG--QDNVSKLLWANWHRDLGELAMEIIGTS--------TLLT
MLBr_00737|M.leprae_Br4923          RAERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAG-----------
                                                    * :             ::                

Mb3604c|M.bovis_AF2122/97           -GLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR---
Rv3573c|M.tuberculosis_H37Rv        -GLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR---
TH_4559|M.thermoresistible__bu      TPQIAALTATAILHKPIFTLRGGTNEVLRGVVAR-GMGLR----
MAV_1814|M.avium_104                NPDLTAMLTTAWLHKPMFTLRGGTNEVLRGVIAR-GMGLR----
MSMEG_2879|M.smegmatis_MC2_155      PQQARDLITAAVDQRPGFTLRGGTNEVLRGVIAR-GLGLR----
Mvan_2876|M.vanbaalenii_PYR-1       GPGFRDLIAVAVDQRPGFTLRGGTTEVLRGVIAR-GLGMR----
MMAR_3511|M.marinum_M               DSEFAALVTAALDQRPGFTLRGGTNEVLRGVIAR-GLGLR----
MUL_2757|M.ulcerans_Agy99           DPEFAALVTAALDQRPGFTLRGGTNEVLRGVIAR-GLGLR----
Mflv_5166|M.gilvum_PYR-GCK          HGGYRAMLDDAVVQRPGFTLRGGTNEILRGVIAR-GLGMR----
MAB_0597|M.abscessus_ATCC_1997      NAGEMDEWQRLFLFSRADTIYGGSNEIQRNIISERVLGLPREAR
MLBr_00737|M.leprae_Br4923          -YTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR------
                                                       :  *: ::   : :.  :