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SSFDALIAREPELAELRSAIRDFLRADRAEFGWMPAVDAWLGQWDEGFSARLGAAGFLGLTVPKRYGGHG LGHLHRYVVTEELIASGAPVAAHWTADRQVAPGLLSYGSEEQCERLLPKIVAGKLYSSIGMSEHGAGSDL AAVSTKAVRAEGGWVLSGTKVWTSGAHRAHQVVVLARTSPPDPHNRHNGFSQFLVPCDAKGVRVEPILLM SGAHHFNEVILDSVFVADGDVLGEVGNGWQQVTSELSFERSGPERILSTGPLLLAAIRALSNGPAPDERT ATVVGDLLARLISLRQLSLSVARTLTEGGDAANLAALVKDLGTRFEAESVEVVADLLEWSTPNPDLTAML TTAWLHKPMFTLRGGTNEVLRGVIARGMGLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1814 | - | - | 100% (382) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_2554 | - | 0.0 | 82.72% (382) | acyl-CoA dehydrogenase, central region |
| M. avium 104 | MAV_0587 | - | 6e-40 | 35.19% (341) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3604c | fadE34 | 4e-39 | 33.42% (386) | acyl-CoA dehydrogenase FADE34 |
| M. gilvum PYR-GCK | Mflv_5166 | - | 1e-102 | 52.79% (377) | Fis family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3573c | fadE34 | 4e-39 | 33.42% (386) | acyl-CoA dehydrogenase FADE34 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-20 | 30.05% (203) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0595c | - | 1e-38 | 30.91% (385) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_3511 | - | 1e-108 | 55.65% (372) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2879 | - | 1e-106 | 54.21% (380) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4559 | - | 1e-173 | 76.18% (382) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2757 | - | 1e-108 | 54.47% (380) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2876 | - | 1e-107 | 53.76% (372) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3604c|M.bovis_AF2122/97 MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRP
Rv3573c|M.tuberculosis_H37Rv MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRP
MAV_1814|M.avium_104 --------------------------------------------------
TH_4559|M.thermoresistible__bu --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2876|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3511|M.marinum_M --------------------------------------------------
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0595c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 VFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAV
Rv3573c|M.tuberculosis_H37Rv VFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAV
MAV_1814|M.avium_104 --------------------------------------------------
TH_4559|M.thermoresistible__bu --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2876|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3511|M.marinum_M --------------------------------------------------
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0595c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 ATLVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAP
Rv3573c|M.tuberculosis_H37Rv ATLVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAP
MAV_1814|M.avium_104 --------------------------------------------------
TH_4559|M.thermoresistible__bu --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2876|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3511|M.marinum_M --------------------------------------------------
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0595c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 GGVVLLPADGNWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLE
Rv3573c|M.tuberculosis_H37Rv GGVVLLPADGNWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLE
MAV_1814|M.avium_104 --------------------------------------------------
TH_4559|M.thermoresistible__bu --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2876|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3511|M.marinum_M --------------------------------------------------
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0595c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 VSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAVK
Rv3573c|M.tuberculosis_H37Rv VSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAVK
MAV_1814|M.avium_104 --------------------------------------------------
TH_4559|M.thermoresistible__bu --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2876|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3511|M.marinum_M --------------------------------------------------
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0595c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 HLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKAN
Rv3573c|M.tuberculosis_H37Rv HLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKAN
MAV_1814|M.avium_104 --------------------------------------------------
TH_4559|M.thermoresistible__bu --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2876|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3511|M.marinum_M --------------------------------------------------
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0595c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 AKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALTQAG
Rv3573c|M.tuberculosis_H37Rv AKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALTQAG
MAV_1814|M.avium_104 --------------------------MSSFDALIARE----PELAELRSA
TH_4559|M.thermoresistible__bu --------------------------VSQFDALRANE----PELADLRAS
MSMEG_2879|M.smegmatis_MC2_155 --------------------------MAIPRLVPALD-TEPADATALRAE
Mvan_2876|M.vanbaalenii_PYR-1 --------------------------MARTRLVPPAG-VDHADTARLRAD
MMAR_3511|M.marinum_M ---------------------MADALMALPRLVPPAGALDSPRADVLRGE
MUL_2757|M.ulcerans_Agy99 --------------------------MALPRLVPPAGALDSPRADVLRGE
Mflv_5166|M.gilvum_PYR-GCK --------------------------MNTSRLVPPVA-DDPHAMDGLRDE
MAB_0595c|M.abscessus_ATCC_199 -----------------------------------MDLLLDDETEAFRAE
MLBr_00737|M.leprae_Br4923 -------------------------MVGWSGNPLFDLFKLPEEHNELRAT
:
Mb3604c|M.bovis_AF2122/97 VRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAPHWPA
Rv3573c|M.tuberculosis_H37Rv VRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAPHWPA
MAV_1814|M.avium_104 IRDFLRADRAEFG-----WMPAVDAWLGQWDEGFSARLGAAGFLGLTVPK
TH_4559|M.thermoresistible__bu VREFLERDRAEFG-----WEPDVDSWLGQWDEGFSARLAAAGYVGMTIPK
MSMEG_2879|M.smegmatis_MC2_155 VRAFLDEQRAAGT-----FTPAVDAWLCGWDEKFTTALAARGWLGMTVPK
Mvan_2876|M.vanbaalenii_PYR-1 VRAFLAEQLAAQT-----FVPSVDSWLCGWDEAFTEALAARGYLGMTVPE
MMAR_3511|M.marinum_M VRAFLAEQSAAGG-----FTPSVDAWLSAWDEDFTAALADRGWLGMTVPV
MUL_2757|M.ulcerans_Agy99 VRAFLAEQSAAGG-----FTPSVDAWLSAWDEDFTAALADRGWLGMTVPV
Mflv_5166|M.gilvum_PYR-GCK VRQFVAEQRDAGR-----IGRQVDSWLTGWDEDFSRALAARGWLGMTVPE
MAB_0595c|M.abscessus_ATCC_199 VREFLVSNVPNPP-----LPSYDSPEGAAAHRQWERTLYDAGFSAVSWPK
MLBr_00737|M.leprae_Br4923 IRALAEKEIAPHA--------ADVDQRARFPEEALAALNASGFNAIHVPE
:* : . * * . *
Mb3604c|M.bovis_AF2122/97 PYG-RGASPAEQLLIDQELAAAKVERPDLVIG-WWAAPTILEHGTPEQIE
Rv3573c|M.tuberculosis_H37Rv PYG-RGASPAEQLLIDQELAAAKVERPDLVIG-WWAAPTILEHGTPEQIE
MAV_1814|M.avium_104 RYGGHGLGHLHRYVVTEELIASGAPVAAHWTADRQVAPGLLSYGSEEQCE
TH_4559|M.thermoresistible__bu EYGGHGLTHLHRYVVTEELLAQGAPVAAHWVADRQVVPGLLAYGTEEQRQ
MSMEG_2879|M.smegmatis_MC2_155 EYGGQGRSFLHRFVVTEELLAAGVPVAAHWIADRQIVPSLLKYGTERQKQ
Mvan_2876|M.vanbaalenii_PYR-1 EYGGHGRSHIERFVVTEELLAAGAPVAAHWIADRQIVPALLKHGTDAQKR
MMAR_3511|M.marinum_M EYGGHGRTFLERFVVTEELLAAGAPVAAHWIADRQIVPSLLKYGTELQKS
MUL_2757|M.ulcerans_Agy99 EYGGHGRTFLERFVVTEELLAVGAPVAAHWIADRQIVPSLLKYGTELQKS
Mflv_5166|M.gilvum_PYR-GCK EYGGHGRSFLERFVVTEELLAAGAPVGAHWIADRQIVPSLLKYGTETQKR
MAB_0595c|M.abscessus_ATCC_199 EYGGRDVTPLQWVIFEEEYFKAGAPARISQNGMFLLGPTLFAHGSKDQLD
MLBr_00737|M.leprae_Br4923 EYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKK
** :. :. :* . :: *:
Mb3604c|M.bovis_AF2122/97 RFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVWTS
Rv3573c|M.tuberculosis_H37Rv RFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVWTS
MAV_1814|M.avium_104 RLLPKIVAGKLYSSIGMSEHGAGSDLAAVSTKAVRAEGGWVLSGTKVWTS
TH_4559|M.thermoresistible__bu RLLPRIAAGKFFSSIGMSEHGAGSDLAAVQTKAVRTDGGWVLNGTKVWTS
MSMEG_2879|M.smegmatis_MC2_155 EFLPRIAAGQCFFGIGMSEPDSGSDLASVRTRAVQVEGGWRLTGTKVWTS
Mvan_2876|M.vanbaalenii_PYR-1 EFLPKIAAGKCFFGIGMSEPDSGSDLASVRTRATRTDGGWSLSGTKVWTS
MMAR_3511|M.marinum_M HFLPRIVRGECFFGIGMSEPDSGSDLASVRTRAVRGEGGWLLSGTKVWTS
MUL_2757|M.ulcerans_Agy99 HFLPRIVRGECFFGIGMSEPDSGSDLASVRTRAVRGEGGWLLSGTKVWTS
Mflv_5166|M.gilvum_PYR-GCK RYLPEIAAGRCYFGIGMSEPDSGSDLASVRTKASPVDGGWSVTGAKVWTS
MAB_0595c|M.abscessus_ATCC_199 RVLPKMANGEEIWAQAWSEPESGSDLASLRSPARKVDGGWRLSGQKIWSS
MLBr_00737|M.leprae_Br4923 QVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCWIT
. :* ** :*** *:: : * ..* :.* * * :
Mb3604c|M.bovis_AF2122/97 AAHKARWGVCLARTDPDAP--KHKGITYFLVDMTTPGIEIRPLREITGDS
Rv3573c|M.tuberculosis_H37Rv AAHKARWGVCLARTDPDAP--KHKGITYFLVDMTTPGIEIRPLREITGDS
MAV_1814|M.avium_104 GAHRAHQVVVLARTSPPDPHNRHNGFSQFLVPCDAKGVRVEPILLMSGAH
TH_4559|M.thermoresistible__bu GAHKAHQVVVLARTSPPDPQKRHAGFSQFLVPCDAKGVRIEPILLMNGDH
MSMEG_2879|M.smegmatis_MC2_155 GAHRAHAFIVLARTAPVDPAHRHAGLSQFIVRFDGPGVEVRPIISMNGGH
Mvan_2876|M.vanbaalenii_PYR-1 GAHRAHAFIVLARTAPADPAHRHDGLSQFIVRFDGPGVEVRPIVSMNGGH
MMAR_3511|M.marinum_M GAHRAHAFIVLARTAPVDPDHRHAGLSQFIVDLRGPGVQTRPIISMNGAH
MUL_2757|M.ulcerans_Agy99 GAHRAHAFIVLARTAPVDPDHRHAGLSQFIVDLRGPGVQTRPIISMNGAH
Mflv_5166|M.gilvum_PYR-GCK GAHRADAFICLARTEPVDPAHRHAGLSQFIVDLRSPGVDIRPIVSMDGRH
MAB_0595c|M.abscessus_ATCC_199 RAPFADRAFGLFRSDPDAQ--RHQGLTYFMFDLKAEGITVRPIPQLDGDP
MLBr_00737|M.leprae_Br4923 NGGKSTWYTVMAVTDPDKG---ANGISAFIVHKDDEGFSIGPKEKKLGIK
. : : : * *:: *:. *. * *
Mb3604c|M.bovis_AF2122/97 L--FNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANER--------VAMA
Rv3573c|M.tuberculosis_H37Rv L--FNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANER--------VAMA
MAV_1814|M.avium_104 H--FNEVILDSVFVADGDVLGEVGNGWQQVTSELSFER--------SGPE
TH_4559|M.thermoresistible__bu H--FNEVSFEDVFIPDADVLGEIGNGWHQVTAELSFER--------SGPE
MSMEG_2879|M.smegmatis_MC2_155 H--FNEVILDDAFVPDDMVFGQIGNGWQQVTSELSFER--------SGPE
Mvan_2876|M.vanbaalenii_PYR-1 H--FNEVILDGAFVPEDMVFGEIGDGWSQVTSELSFER--------SGPE
MMAR_3511|M.marinum_M H--FNEVILDNACVPDEMVFGAIGNGWTQVTSELSFER--------SGPE
MUL_2757|M.ulcerans_Agy99 H--FNEVILDNAHVPDEMVFGAIGNGWTQVTSELSFER--------SGPE
Mflv_5166|M.gilvum_PYR-GCK H--FNEVLLDDVFVADDMVFGAIGDGWQQVTSELAFER--------SGPE
MAB_0595c|M.abscessus_ATCC_199 G--FAEIFLDDVFVPDEDVIGAVHDGWRVAMSTSSNER--------GMSL
MLBr_00737|M.leprae_Br4923 GSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQ
*: :: :. :.* *: . : *
Mb3604c|M.bovis_AF2122/97 TGTALGNPMEELLKVLGDMELDVAQQDR-LGRLILLAQAGALLDRRIAEL
Rv3573c|M.tuberculosis_H37Rv TGTALGNPMEELLKVLGDMELDVAQQDR-LGRLILLAQAGALLDRRIAEL
MAV_1814|M.avium_104 RILSTGPLLLAAIRALSNGPAPDERTATVVGDLLARLISLRQLSLSVART
TH_4559|M.thermoresistible__bu RILSTVPLIVAAIRLLGNTPGTDDTTARIVGDLLGRLISLRQLSVWVART
MSMEG_2879|M.smegmatis_MC2_155 RLLSTFVLLAQTTDSMARQQISRDAD---LGRLVARIAGLHHMSMAVAGA
Mvan_2876|M.vanbaalenii_PYR-1 RLLSTFPLLAATAESMAQHRISYDAA---LGRMVARVAGLHQMSTAVAGA
MMAR_3511|M.marinum_M RFLSTFVLLAATAESMAEQRFTRDQQ---LGRLVARIAGLHQMSAAVAGA
MUL_2757|M.ulcerans_Agy99 RFLSTFVLLAATAESMAEQRFTRDQQ---LGRLVARIAGLHQMSAAVAGA
Mflv_5166|M.gilvum_PYR-GCK RFLSTFPLLAELAALMNDG-LPRHND---LGRYVARVAGLHQMSTAVAGA
MAB_0595c|M.abscessus_ATCC_199 RSPGRFLATADRLVELWKSVPENEFASERVADAWIAAQAYRLHTFGTVTR
MLBr_00737|M.leprae_Br4923 GALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAAR
: :. . .
Mb3604c|M.bovis_AF2122/97 AVGGQ-DPGAQSSVRKLIGVRYRQALAEYLMEVSDGG-------------
Rv3573c|M.tuberculosis_H37Rv AVGGQ-DPGAQSSVRKLIGVRYRQALAEYLMEVSDGG-------------
MAV_1814|M.avium_104 LTEGG-DAANLAALVKDLGTRFEAESVEVVADLLEWS----------TPN
TH_4559|M.thermoresistible__bu LSEHK-DAANQAALVKDLGTRFEQDSIEVIADVLDRV----------SPT
MSMEG_2879|M.smegmatis_MC2_155 LERHE-PADVPAAVVKVLGTTTEGD-IADFADLHRGD--------DGALP
Mvan_2876|M.vanbaalenii_PYR-1 LERDE-PADVPAAVVKLLGTSTEGD-IADFADLHTGD--------ETTTG
MMAR_3511|M.marinum_M LERND-PADLPAAVVKVLGTSTEGD-IAELADLADS---------HRPRD
MUL_2757|M.ulcerans_Agy99 LERND-PADLPAAVVKVLGTSTESD-IAELADLADSTDLADSGAPHRPRD
Mflv_5166|M.gilvum_PYR-GCK LERHE-PADTAAAVVKVLGTSTEGD-IADFADLLTDA--------CAPDH
MAB_0595c|M.abscessus_ATCC_199 LAGGG-ELGAESSITKVFWSELDVALHETAIDLRGAEG------------
MLBr_00737|M.leprae_Br4923 AERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAG------------
:: * : ::
Mb3604c|M.bovis_AF2122/97 GLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR----------
Rv3573c|M.tuberculosis_H37Rv GLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR----------
MAV_1814|M.avium_104 PDLTAMLTTAWLHKPMFTLRGGTNEVLRGVIAR-GMGLR-----------
TH_4559|M.thermoresistible__bu PQIAALTATAILHKPIFTLRGGTNEVLRGVVAR-GMGLR-----------
MSMEG_2879|M.smegmatis_MC2_155 QQARDLITAAVDQRPGFTLRGGTNEVLRGVIAR-GLGLR-----------
Mvan_2876|M.vanbaalenii_PYR-1 PGFRDLIAVAVDQRPGFTLRGGTTEVLRGVIAR-GLGMR-----------
MMAR_3511|M.marinum_M SEFAALVTAALDQRPGFTLRGGTNEVLRGVIAR-GLGLR-----------
MUL_2757|M.ulcerans_Agy99 PEFAALVTAALDQRPGFTLRGGTNEVLRGVIAR-GLGLR-----------
Mflv_5166|M.gilvum_PYR-GCK GGYRAMLDDAVVQRPGFTLRGGTNEILRGVIAR-GLGMR-----------
MAB_0595c|M.abscessus_ATCC_199 -ELTNAWTDGYLFSLGGPIYAGTNEIQRNIIAERILGLPRESSASARTGG
MLBr_00737|M.leprae_Br4923 YTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR-------------
: ** :: : :. :
Mb3604c|M.bovis_AF2122/97 --
Rv3573c|M.tuberculosis_H37Rv --
MAV_1814|M.avium_104 --
TH_4559|M.thermoresistible__bu --
MSMEG_2879|M.smegmatis_MC2_155 --
Mvan_2876|M.vanbaalenii_PYR-1 --
MMAR_3511|M.marinum_M --
MUL_2757|M.ulcerans_Agy99 --
Mflv_5166|M.gilvum_PYR-GCK --
MAB_0595c|M.abscessus_ATCC_199 AK
MLBr_00737|M.leprae_Br4923 --