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TASIGSEADLCHWLVNYLVTNIGCTPDEVDLNLSLTDLGMSSRDAVVLSGELTDLLGKTVSPIDFWEHPT INALAAYLIAPAPDPESESAPRRSVQGALEEPIAVIGMGCRFPGGISGPEALWQFLCDRRSSIGQVPNER WELFDDGSPEVKALLARTTRWGSFLEDIDAFDSEFFEISPSEADKMDPQQRLLLEVAWEALEHAGISSNS LRRSQTGVFAGSCLSEYGAIASTDLSQVDGWSNTGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIH LACQSLRTADANLAIAAGVNLLLSPAVFRGFDQVGALSPTGCCRAFDAAADGFVRGEGAGVVVLKRLTDA QRDGDRVLAIIRGSAVNQDGRSNGLMAPNPAAQVAVLRTAYANAAMPPTAIDYVETHGTGTLLGDPIEAR ALGAVLGRGRAEDSPLLIGAVKTNLGHLEAAAGIAGFIKTVLAVQRGQIPPNQRFESPNLHIPFAELRMK VVDKHMEWPDTGHLRRAAVSSFGFGGTNAHVVIEQGPELTPVTECSSNTAVSTLVVTGKTASRVAAMAGM LADWVEGPGAEVALADVAHTLNHHRSRHAKFGTVVARDRIQAVAGLRALAAGKQAPGVVGQQDGTPGSGT VFVYSGRGSQWAGMGRQLLADEPAFTAAVAELEPVFVVHAGFSLHDVLANGKELVGIEQIQLGLIGMQLT LTELWRSYGVQPDLVIGHSLGEVAAAVVAGALTAAEGLRVTATRSRLMAPLSGQGGMALLELDAVETEAL IVDYSQVTLAIYNSPRQTVIAGPTEQIDELIDRVRAQNRFASRVNIEVAPHNPAMDALQPQMRSELADVA PRTPTIPILSTTYADLGSCPVFDAQHWATNMRNPVHFQQAIMTAGTDHRTFIEISAHPLLTQAITDTLHG TRCISIGTLQRDADDTVTFHTNLNNVHTVHPPHTPHPAEPHVTIPSTPWQHTRHWIPRKRSVNSIGLAPQ VGTLLGQHTAVSGILPIHLWQARLAPQAKPYRGWHRVHGVEVVPASIVLRTILCAAAELGYSTLFEIRFE QPIFANLPRLIQVVVDNQLISLASSPATETPQHRWTRHVTAQLSSASARSAVPSDHPDQINGHLEVISDP IPDVASLLALCGVDGLPFEWSVKSWAKKTQQSTSRTVEIEFPDTLPDGAIAPLLDAAILIPALADVTETQ FYVPASIKQVWLGDTATGPCGAVTLNRTACDDDGITVDVTVADGSGVPLALMRSLRYRALDLDNAQQDYS TVFVESHVDALTDARNFVHAIDWQPRTDLDCSNTPVASSGSVAVIGDARAGFGLLLKEAGYTLAAPADGV SEVRYVVYVADPHPATTAETDVDFAVRITAEISDLVRALAKREPGKPVALWIVTRGVYESVASSALRQSF LWGFGGVIAAEHPEMWGGLVDLAASALGADRDDILDQFGPTLASLLQTPTRSIVVLRDGVVLAPTLVPIR SEPVRKSLQCKSDGAYLITGGMGALGLLMADWLADRGARRLVLMGRTPLPPRRDWELDTLDAGLRQKIDA ICALEMRGVTVEAVAVDVGHHDDVQALLAKRDRDGAAPIRGIIHAAGVTNDQLVTNMTDDPVRQVMWPKI AGCQVLHEAFPPGSVDFFYLTSSAAGIFGIPGQGSYAAANSYLDALARTRRQQGCHTMSIDWVAWRGLGF AANAQIVSDELQRMGSRDITPSEAFTAWEYVDAYDVAQAVVLPVPRSYGSAGSTAGDSYLVPARNWSQME AAEVRKELESGLRTIIAAELRVAEAELDTDRPFAELGLNSLMAMAIRREAEQFIGIELSAIMLFNHPTVA LLAAYLTKVVAPQHDSQGDEMAALSASAGGVLDSLFDRIESTSTEAEGLV*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. leprae Br4923 | MLBr_02357 | - | - | 100% (1871) | polyketide synthase |
M. leprae Br4923 | MLBr_02356 | - | 0.0 | 79.93% (872) | polyketide synthase |
M. leprae Br4923 | MLBr_02355 | - | 0.0 | 47.74% (1481) | polyketide synthase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2956 | ppsA | 0.0 | 75.85% (1888) | phenolpthiocerol synthesis type-I polyketide synthase PPSA |
M. gilvum PYR-GCK | Mflv_3395 | - | 0.0 | 53.77% (1882) | acyl transferase domain-containing protein |
M. tuberculosis H37Rv | Rv2931 | ppsA | 0.0 | 75.95% (1888) | phenolpthiocerol synthesis type-I polyketide synthase PPSA |
M. abscessus ATCC 19977 | MAB_3148c | - | 1e-176 | 32.19% (1370) | polyketide synthase Pks5 |
M. marinum M | MMAR_1776 | ppsA | 0.0 | 81.04% (1002) | phenolpthiocerol synthesis type-I polyketide synthase PpsA |
M. avium 104 | MAV_2370 | - | 0.0 | 33.86% (1382) | mycocerosic acid synthase |
M. smegmatis MC2 155 | MSMEG_6767 | - | 0.0 | 31.45% (1879) | mycocerosic acid synthase |
M. thermoresistible (build 8) | TH_2454 | - | 0.0 | 35.61% (1814) | PUTATIVE beta-ketoacyl synthase |
M. ulcerans Agy99 | MUL_2019 | ppsA | 0.0 | 80.94% (1002) | phenolpthiocerol synthesis type-I polyketide synthase PpsA |
M. vanbaalenii PYR-1 | Mvan_3128 | - | 0.0 | 55.48% (1878) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_3395|M.gilvum_PYR-GCK MTSAFD-EDAIRNWLVDYLVTNIGCSPDEIDFDAPLNDLAVGSSDAVVLT Mvan_3128|M.vanbaalenii_PYR-1 MTSAFD-EDAIRNWLVDYLVTNIGCSPDEINFDAPLNDLAVGSSDAVVLT Mb2956|M.bovis_AF2122/97 MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLADLGVSSRDAVVLS Rv2931|M.tuberculosis_H37Rv MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLADLGVSSRDAVVLS MLBr_02357|M.leprae_Br4923 MTASIGSEADLCHWLVNYLVTNIGCTPDEVDLNLSLTDLGMSSRDAVVLS MMAR_1776|M.marinum_M MTPSIGGEADLRHWLVDYLVTNIGCPPDEVDPNLSLADLGVSSRDAVVLS MUL_2019|M.ulcerans_Agy99 MTPSIGGEADLRHWLVDYLVTNIGCPPDEVDPNLSLADLGVSSRDAVVLS TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK GELSELLGRTVSPVEFWQYPTINALARFLTGGEVEAVAEVSPIRRVS--- Mvan_3128|M.vanbaalenii_PYR-1 GELSELLGRTVSPVEFWQYPTINALAKFLTGGEVEPAIEASVGGGVSRDY Mb2956|M.bovis_AF2122/97 GELSELLGRTVSPIDFWEHPTINALAAYLAAPEPSPDSDAAVKRGAR--- Rv2931|M.tuberculosis_H37Rv GELSELLGRTVSPIDFWEHPTINALAAYLAAPEPSPDSDAAVKRGAR--- MLBr_02357|M.leprae_Br4923 GELTDLLGKTVSPIDFWEHPTINALAAYLIAPAPDPESESAPRRSVQ--- MMAR_1776|M.marinum_M GELTELLGRTVSPIDFWEHPTINDLAAYLTAPEPSTGAEAAVSRTVR--- MUL_2019|M.ulcerans_Agy99 GELTELLGRTVSPIDFWEHPTINDLAAYLTAPEPSTGAEAAVSRTVR--- TH_2454|M.thermoresistible__bu -------------------------------------MSVDVTAKAR--- MAB_3148c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_2370|M.avium_104 -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------MPMPNTDHTS--- Mflv_3395|M.gilvum_PYR-GCK ---DDAIAVVGLGVRFPGGG---DDIHGPDDLWEFLAQGRSAVSQVPPTR Mvan_3128|M.vanbaalenii_PYR-1 GADDEPIAVIGLGCRFPGGDGLDGNITGPDAYWRFLMEGRSAVRQVPEER Mb2956|M.bovis_AF2122/97 NSLDEPIAVVGMGCRFPGG------ISCPEALWDFLCERRSSISQVPPQR Rv2931|M.tuberculosis_H37Rv NSLDEPIAVVGMGCRFPGG------ISCPEALWDFLCERRSSISQVPPQR MLBr_02357|M.leprae_Br4923 GALEEPIAVIGMGCRFPGG------ISGPEALWQFLCDRRSSIGQVPNER MMAR_1776|M.marinum_M GSLEEPIAVVGMGCRFPGG------ISGPEALWQFLCDRKSSIGRVPDER MUL_2019|M.ulcerans_Agy99 GSLEEPIAVVGMGCRFPGG------ISGPEALWQFLCDRKSSIGRVPDER TH_2454|M.thermoresistible__bu --PDDPIAIIGIGCRLAGR------ITSPEEFWGFLLAGGSNVREIPAER MAB_3148c|M.abscessus_ATCC_199 -----------MGCRLPGG------IESPEQFWQALLRGEDFITEVPPAR MAV_2370|M.avium_104 ---MVPVAVIGMACRLPGA------VDSPERLWEALLRGDDFVTEIPPDR MSMEG_6767|M.smegmatis_MC2_155 ---RQPLAIVGIGCRFPGG------ADSAQRYWDLLCNNIDATREVPENR :. *:.* .: * * . .:* * Mflv_3395|M.gilvum_PYR-GCK WSWYDDGSPEGAAALAHTTRWGSYLSEIDEFDADYFEISPSEADKMDPQQ Mvan_3128|M.vanbaalenii_PYR-1 WESFQINTPEAAAALAGTTRWGAFLRDLDAFDAEFFEISPSEADKMDPQQ Mb2956|M.bovis_AF2122/97 WQPFEGGPPEVAAALARTTRWGSFLPDIDAFDAEFFEISPSEADKMDPQQ Rv2931|M.tuberculosis_H37Rv WQPFEGGPPEVAAALARTTRWGSFLPDIDAFDAEFFEISPSEADKMDPQQ MLBr_02357|M.leprae_Br4923 WELFDDGSPEVKALLARTTRWGSFLEDIDAFDSEFFEISPSEADKMDPQQ MMAR_1776|M.marinum_M WAQFDDGSPAVKALLARTTRWGSYLTDIDAFDADFFEISASEADKMDPQQ MUL_2019|M.ulcerans_Agy99 WAQFDDGSPAVKALLARTTRWGSYLTDIDAFDADFFEISASEADKMDPQQ TH_2454|M.thermoresistible__bu WEPYLRRDPRNAAVLREITPWGTFLDDLAGFDAEFFGVSPREAELTDPQQ MAB_3148c|M.abscessus_ATCC_199 WDLTEYYDPESGVPGKSPSKWGAFLEDVGGFDADFFSINEREAVSIDPQH MAV_2370|M.avium_104 WDADEYYDPEPGVPGRSVSRWGAFIDDVAGFDPEFFGINEREATAMDPQH MSMEG_6767|M.smegmatis_MC2_155 WNAAKYHDPNPAKIGKIVTRRGGFLDQIDQFDPQFFGISPREAHSLDPQQ * * : * :: :: **.::* :. ** ***: Mflv_3395|M.gilvum_PYR-GCK RLLLEVTHEALEHAGIRPDVLRHTQTGVFVGACLGEYAVMASKDLA---E Mvan_3128|M.vanbaalenii_PYR-1 RLLLEVTQEALEHAGIPTHTLRHSQTGVFAAACLGEYGYLSTVDLG---D Mb2956|M.bovis_AF2122/97 RLLLEVAWEALEHAGIPPGTLRRSATGVFAGACLSEYGAMASADLS---Q Rv2931|M.tuberculosis_H37Rv RLLLEVAWEALEHAGIPPGTLRRSATGVFAGACLSEYGAMASADLS---Q MLBr_02357|M.leprae_Br4923 RLLLEVAWEALEHAGISSNSLRRSQTGVFAGSCLSEYGAIASTDLS---Q MMAR_1776|M.marinum_M RLLLEVAWEALEHAGIPPSSLRRSQTGVFAGSCLSEYGAIASTDLT---Q MUL_2019|M.ulcerans_Agy99 RLLLEVAWEALEHAGIPPSSLRRSQTGVFAGSCLSEYGAIASTDLT---Q TH_2454|M.thermoresistible__bu RLALEVSWEALEHAGVPPRSLAGTDTAVLMGVNSDDYGRLLMEDLP---G MAB_3148c|M.abscessus_ATCC_199 RVLLETSWQAVEHAGIDPRALAGSQTGVFVGVTHNDYQLVAADAAD---L MAV_2370|M.avium_104 RLLLETSWEAMEHAGLTEERVADSRTGVFIGLTHGDYQLLAADTRS---V MSMEG_6767|M.smegmatis_MC2_155 RLLLQATWEALEDGGIPADELAGTDVGVFVGGFTLDYQLLQNQGRTSRYR *: *:.: :*:*..*: : : ..*: . :* : Mflv_3395|M.gilvum_PYR-GCK VNAYSGTGGALSIIANRVSYFYDLRGPSVTIDTACSSSLVAIHLACQSLR Mvan_3128|M.vanbaalenii_PYR-1 VDSWSGTGGALSIIANRVSYYFDLRGPSVTIDTACSSSLVTIHLACQSLR Mb2956|M.bovis_AF2122/97 VDGWSNSGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLR Rv2931|M.tuberculosis_H37Rv VDGWSNSGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLR MLBr_02357|M.leprae_Br4923 VDGWSNTGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLR MMAR_1776|M.marinum_M VDGWSNTGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLR MUL_2019|M.ulcerans_Agy99 VDGWSNTGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLR TH_2454|M.thermoresistible__bu IEAWTGIGTSLCGIANRVSHLLDLRGPSVALDAACAASLVAVHNACQLLR MAB_3148c|M.abscessus_ATCC_199 GGPYGFAGTNFCMASGRISYALGVHGPSLTVDAGCAAGLATVHMGCQSLA MAV_2370|M.avium_104 EGAYGFSGSNFSLASGRIAYALGVHGPALTVDTACSSGLTAIHLACRSLH MSMEG_6767|M.smegmatis_MC2_155 FKPHSATGMMMTMLANRISHAFDFRGPSMAIDTACSSSLVAVHLAAQSIW * : :.*::: ..:**::::*:.*::.*.::* ..: : Mflv_3395|M.gilvum_PYR-GCK SGDSDVALAGGVNVILSPAVTRSFDQAEAMSKSGRCHAFDSRADGFVRGE Mvan_3128|M.vanbaalenii_PYR-1 SGDSNMALAAGVNLLLSPAVTRSFDQLEAMSRTGQCHAFDAGADGFVRGE Mb2956|M.bovis_AF2122/97 TQDCHLAIAAGVNLLLSPAVFRGFDQVGALSPTGQCRAFDATADGFVRGE Rv2931|M.tuberculosis_H37Rv TQDCHLAIAAGVNLLLSPAVFRGFDQVGALSPTGQCRAFDATADGFVRGE MLBr_02357|M.leprae_Br4923 TADANLAIAAGVNLLLSPAVFRGFDQVGALSPTGCCRAFDAAADGFVRGE MMAR_1776|M.marinum_M MQDSNLAIAAGVNLLLSPAVFRGFDQVGALSPTGNCRAFDAAADGFVRGE MUL_2019|M.ulcerans_Agy99 MQDSNLAIAAGVNLLLSPAVFRGFDQVGALSPTGNCRAFDAAADGFVRGE TH_2454|M.thermoresistible__bu AGETGLAIAGGVSALIGPGLTRVLDKAGATAPDGRCKSFDASADGYGRGE MAB_3148c|M.abscessus_ATCC_199 AGESDLVLAGGVNLVLEPRRYVGASQQRMLSPTGRCHTFTGEADGFVMSE MAV_2370|M.avium_104 EGESDLALAGGATLALDPRKFSAGSAEGMLSPTGRCHAFDVAADGFVGGE MSMEG_6767|M.smegmatis_MC2_155 DGDCDVALAGGVNIMVGPNTAIAESKSGFLSPEGRSKAFSDTADGYARGE : :.:*.*.. : * . : * .::* ***: .* Mflv_3395|M.gilvum_PYR-GCK GCGVAVLKRLSDAQRDGDRVLAVVRGSAVNQDGRSNGLMAPNPAAQMSVL Mvan_3128|M.vanbaalenii_PYR-1 GCGVTVLKRLSDAQRDGDRILAVIRGSAVNQDGRSNGLMAPNPAAQMAVL Mb2956|M.bovis_AF2122/97 GAGVVVLKRLTDAQRDGDRVLAVICGSAVTQDGRSNGLMAPNPAAQMAVL Rv2931|M.tuberculosis_H37Rv GAGVVVLKRLTDAQRDGDRVLAVICGSAVNQDGRSNGLMAPNPAAQMAVL MLBr_02357|M.leprae_Br4923 GAGVVVLKRLTDAQRDGDRVLAIIRGSAVNQDGRSNGLMAPNPAAQVAVL MMAR_1776|M.marinum_M GAGVVVLKRLTDAQQDGDRVLAVICGSAINQDGRSNGLMAPNPAAQQAVL MUL_2019|M.ulcerans_Agy99 GAGVVVLKRLTDAQQDGDRVLAVICGSAINQDGRSNGLMAPNPAAQQAVL TH_2454|M.thermoresistible__bu GAAVVILKRLPDALRDGDRVIAVIRGGAVAQDGRTVGIMSPNGAAQRDLF MAB_3148c|M.abscessus_ATCC_199 GCVMVLLKRLDDAVRDGDRILAVVRGTASNQDGRTVNQSTPSSEAQAAAC MAV_2370|M.avium_104 GSVMLLLKRLNDALRDGDRILAVVRGTAANQDGHTVNIATPSKTAQTAVY MSMEG_6767|M.smegmatis_MC2_155 GGAVVVIKPLAHALRDGDDIYAQILGTAVSQDGHTDGITVPNEEAQEAAI * : ::* * .* :*** : * : * * ***:: . *. ** Mflv_3395|M.gilvum_PYR-GCK RSAYAAAGVEPREVDYIEAHGTGTLLGDPIEARALGSVLGRGRAADAPLL Mvan_3128|M.vanbaalenii_PYR-1 RSAYSAAGVEPRDVDYVETHGTGTLLGDPIEARALGTVLGRGRAADAPLL Mb2956|M.bovis_AF2122/97 RAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALGTVLGRGRPEDSPLL Rv2931|M.tuberculosis_H37Rv RAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALGTVLGRGRPEDSPLL MLBr_02357|M.leprae_Br4923 RTAYANAAMPPTAIDYVETHGTGTLLGDPIEARALGAVLGRGRAEDSPLL MMAR_1776|M.marinum_M RAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALGSVLGRGRPEESPLL MUL_2019|M.ulcerans_Agy99 RAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALGSVLGRGRPEESPLL TH_2454|M.thermoresistible__bu RHTCEITGTSPATVDFVEAHGTGTPTGDPVELDALAAVYGAAHGPDDPCR MAB_3148c|M.abscessus_ATCC_199 RTALAVAGVEADTVGLIEAHGTGTPVGDPIEYTGLAQVYG----VDGPCA MAV_2370|M.avium_104 RAALAAAGVDAGTVGMVEAHGPGTPVGDPIEYASLAEVYG----IDGPCA MSMEG_6767|M.smegmatis_MC2_155 RMALQRAGVEPNDVAYVEAHGTGTPVGDPIEMRALAGALTTDRDATRPLV * : :. . : :*:**.** ***:* .*. . * Mflv_3395|M.gilvum_PYR-GCK IGAIKSNLGHTEAAAGIAGFAKTVLALQRGRIPANLDYQSPNPHIPFDNL Mvan_3128|M.vanbaalenii_PYR-1 LGAVKSNLGHLEAAAGVAGFIKAVLALQHQQIPANLGYEKPNPHIPFDNL Mb2956|M.bovis_AF2122/97 IGSVKTNLGHTEAAAGIAGFIKTVLAVQHGQIPPNQHFETANPHIPFTDL Rv2931|M.tuberculosis_H37Rv IGSVKTNLGHTEAAAGIAGFIKTVLAVQHGQIPPNQHFETANPHIPFTDL MLBr_02357|M.leprae_Br4923 IGAVKTNLGHLEAAAGIAGFIKTVLAVQRGQIPPNQRFESPNLHIPFAEL MMAR_1776|M.marinum_M IGAVKTNLGHTEAAAGIAGFIKAVLAVQHGRIPPNQRFESPNPHIAFADL MUL_2019|M.ulcerans_Agy99 IGAVKTNLGHTEAAAGIAGFIKAVLAVQHGRIPPNQRFESPNPHIAFADL TH_2454|M.thermoresistible__bu VGSVKPNTGHLEGGAGVVGLIKAALALQHGVIPPTAGIRELTPAVDWATN MAB_3148c|M.abscessus_ATCC_199 VGSVKTNFGHTMSAAGALGLMKIVLAVEHGVVPPNLHFTGIPDKLAPVKT MAV_2370|M.avium_104 LASVKTNFGHAQAASGALGMMKAILALQHGVVPRNLHFTQLPDDLARIDT MSMEG_6767|M.smegmatis_MC2_155 IGSVKTNIGHLEAGAGVAGLIKAALIVKHGHIPANLHLKNPTRHVSLTEL :.::*.* ** ..:* *: * * ::: :* . : Mflv_3395|M.gilvum_PYR-GCK RLKVVDEVTDW-KPVGRPRVAGVSSFGFGGTNAHVVLEQAPDPTPAEDTD Mvan_3128|M.vanbaalenii_PYR-1 RLKVIAEHTEWPAPAGRPRRAGVSSFGFGGTNAHVVIEQAPPKAPATNGQ Mb2956|M.bovis_AF2122/97 RMKVVDTQTEW-PATGHPRRAGVSSFGFGGTNAHVVIEQGQEVRPAPGQG Rv2931|M.tuberculosis_H37Rv RMKVVDTQTEW-PATGHPRRAGVSSFGFGGTNAHVVIEQGQEVRPAPGQG MLBr_02357|M.leprae_Br4923 RMKVVDKHMEW-PDTGHLRRAAVSSFGFGGTNAHVVIEQGPELTPVTECS MMAR_1776|M.marinum_M RMKVVDELTDW-PDTGHPRRAGVSSFGFGGTNAHVVIEQGQEAASSPEAG MUL_2019|M.ulcerans_Agy99 RMKVVDELTDW-PDTGHPRRAGVSSFGFGGTNAHVVIEQGQEAASSPEAD TH_2454|M.thermoresistible__bu GLHVPTTVEPFPRRADSPRRAAVCSYGYGGTIAHLLLEEAPAVDETPAAA MAB_3148c|M.abscessus_ATCC_199 NLFVPQTVIPWPGKAQGPRRAGVSAYGMSGSNVHAVVEQAPPVESSTPPA MAV_2370|M.avium_104 KLFVPQQTTPWVSNGGHPRRAAVSSYGLSGTNVHAILEQAPEPAPETVAP MSMEG_6767|M.smegmatis_MC2_155 KLDIPTIGRPFPECDR--RIAGINSFGFGGTNAHVVLAEPPAARHSAETG : : : * *.: ::* .*: .* :: : Mflv_3395|M.gilvum_PYR-GCK VAPAA--ASPVTTLVVAGKSAPRIATTAGMLAEWLAG-DGADVPLDQVAH Mvan_3128|M.vanbaalenii_PYR-1 GEPA------VTTLVVSGRTAERIASEAGMLAEWMAGPEGSLASLPEVAH Mb2956|M.bovis_AF2122/97 LSPA------VSTLVVAGKTMQRVSATAGMLADWMEG-PGADVALADVAH Rv2931|M.tuberculosis_H37Rv LSPA------VSTLVVAGKTMQRVSATAGMLADWMEG-PGADVALADVAH MLBr_02357|M.leprae_Br4923 SNTA------VSTLVVTGKTASRVAAMAGMLADWVEG-PGAEVALADVAH MMAR_1776|M.marinum_M LTPA------LSTLVVAGKTPARVAATAGMLADWMEG-PGAEVALADVAH MUL_2019|M.ulcerans_Agy99 LTPA------LSTLVVAGKTPARVAATAGMLADWMEG-PGAEVALADVAH TH_2454|M.thermoresistible__bu PAPAADAADANSPRFHVIPVSARSGARLARHAAALRGHLSAGADLTAVAA MAB_3148c|M.abscessus_ATCC_199 VESP---LGSQLIFPVSSTSAEELRRTAARLADWVAE--RPEVAPGDVGY MAV_2370|M.avium_104 EGIS---AESPLLFPLSSTSADELRRTAGRLADWVHA--HGDLALPDLAY MSMEG_6767|M.smegmatis_MC2_155 DHRV------LTVLPISARSEEALVATAGRLAGHLAA--HPEVTLADLGY . * : :. Mflv_3395|M.gilvum_PYR-GCK SLNHHRAQHSKFATVCTRDRAGALAGLQALAAGHTAPGVVP-PHQGSCRP Mvan_3128|M.vanbaalenii_PYR-1 TLNHHRSHYNKFATVAARDRDQAIAGLRALAAGQTAPGVVG-APTGARKR Mb2956|M.bovis_AF2122/97 TLNHHRSRQPKFGTVVARDRTQAIAGLRALAAGQHAPGVVN-PAEGSPGP Rv2931|M.tuberculosis_H37Rv TLNHHRSRQPKFGTVVARDRTQAIAGLRALAAGQHAPGVVN-PADGSPGP MLBr_02357|M.leprae_Br4923 TLNHHRSRHAKFGTVVARDRIQAVAGLRALAAGKQAPGVVG-QQDGTPGS MMAR_1776|M.marinum_M TLNHHRSRQARFGTVVARERAQAVAGLRALAANQHAPGVVN-PADAPPEP MUL_2019|M.ulcerans_Agy99 TLNHHRSRQARFGTVVARERAQAVAGLRALAANQHAPGVVN-PADAPPEP TH_2454|M.thermoresistible__bu TMWQRRSHEPVRAAVIARHPGELVAGLDAIATDTRHPAVVAGSVLPAAEA MAB_3148c|M.abscessus_ATCC_199 TLARRRAHRSVRTAVVADGADELIDALRGVAEGDAP----YPAAVAQDDR MAV_2370|M.avium_104 TLARRRVHRPVRTAVLAGDRAQLIEALREVADGDTP----YPAAVGRGDR MSMEG_6767|M.smegmatis_MC2_155 TLSHRRAHLNHRHTFVVDSIDEARRQLQAVADGGQIS------AGRAGEA :: ::* : :. . * :* . Mflv_3395|M.gilvum_PYR-GCK GKVFVYSGQGAQWTGMGRRLLADEPAFAAAVAELEPVFVEQVGFSLQQIL Mvan_3128|M.vanbaalenii_PYR-1 GTVFVYSGQGSQWPGMARQLLADEPAFANALAEIEPVFVEQVGFSLRDVI Mb2956|M.bovis_AF2122/97 GTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQAGFSLHDVL Rv2931|M.tuberculosis_H37Rv GTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQAGFSLHDVL MLBr_02357|M.leprae_Br4923 GTVFVYSGRGSQWAGMGRQLLADEPAFTAAVAELEPVFVVHAGFSLHDVL MMAR_1776|M.marinum_M GTVFVYSGRGSQWAGMGRQLLADEPVFAAAVAELEPVFLAEAGFSLHDVL MUL_2019|M.ulcerans_Agy99 GTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFLAEAGFSLHDVL TH_2454|M.thermoresistible__bu GAVWVFSGHGSHWPGMGRELLEHEPVFAAVIDEIEPVFRAELGFSPRQAL MAB_3148c|M.abscessus_ATCC_199 GPVWLFSGQGSQWAGMGAELLGKEPVFAETIARLEPLIHAESGFSVTDAI MAV_2370|M.avium_104 GPVWVFSGQGSQWAAMGADLLATEPVFAATVAQAEPLIARESGFSVAEAM MSMEG_6767|M.smegmatis_MC2_155 RLAFVCTGMGPQWWQMCRGLLDVFPVFTDSIHRTDRELSRYADWSLLEEL .:: :* *.:* * ** *.*: : . : : .:* : : Mflv_3395|M.gilvum_PYR-GCK A---GGETVTGIDRIQPVLVGMQLALTELWRAYGVHPDAVIGHSMGEVAA Mvan_3128|M.vanbaalenii_PYR-1 A---GGETVSGDAQVQPVLMGLQLALTELWRSYDVHPDAVIGHSMGEVTA Mb2956|M.bovis_AF2122/97 A---NGEELVGIEQIQLGLIGMQLALTELWCSYGVQPDLVIGHSMGEVAA Rv2931|M.tuberculosis_H37Rv A---NGEELVGIEQIQLGLIGMQLALTELWCSYGVRPDLVIGHSMGEVAA MLBr_02357|M.leprae_Br4923 A---NGKELVGIEQIQLGLIGMQLTLTELWRSYGVQPDLVIGHSLGEVAA MMAR_1776|M.marinum_M A---NGTELVGIEQIQLGLIGMQLTLTELWRSYGIQPDLVIGHSMGEVAA MUL_2019|M.ulcerans_Agy99 A---NGTELVGIEQIQLGLIGMQLTLTELWRSYGIQPDLVIGHSMGEVAA TH_2454|M.thermoresistible__bu Q---SGE-LGGTDRVQALTFAVQAGLAAVLRDRGVKPAAVIGHSVGEVAA MAB_3148c|M.abscessus_ATCC_199 S---APETVTGIDRVQPTLFAMQVSLAATLASYGVRPGAVIGHSMGEVAA MAV_2370|M.avium_104 S---APQTVTGQDRVQPTLFTMQVALAATMKAHGVRPGAVIGHSLGEAAA MSMEG_6767|M.smegmatis_MC2_155 TRDEASSRMGETEFAQPANFAIQVALAEQLAHFGITPDAVIGHSAGEVAA : * . :* *: .: * ***** **.:* Mflv_3395|M.gilvum_PYR-GCK SVVAGALSVADGLKVIATRSKLMSRLSGQGAMALIELDPDAATALIAD-- Mvan_3128|M.vanbaalenii_PYR-1 AVVAGALSLADGLKVIAARSSIMSRLAGQGAVALVELDPEAAAAFIAD-- Mb2956|M.bovis_AF2122/97 AVVAGALTPAEGLRVTATRSRLMAPLSGQGGMALLELDAPTTEALIAD-- Rv2931|M.tuberculosis_H37Rv AVVAGALTPAEGLRVTATRSRLMAPLSGQGGMALLELDAPTTEALIAD-- MLBr_02357|M.leprae_Br4923 AVVAGALTAAEGLRVTATRSRLMAPLSGQGGMALLELDAVETEALIVD-- MMAR_1776|M.marinum_M AVVAGALTPAEGLRVTAVRSRLMAPLSGQGGMALLELDASQTEALIAD-- MUL_2019|M.ulcerans_Agy99 AVVAGALTPAEGLRVTAVRSRLMAPLSGQGGMALLGLDASQTEALIAD-- TH_2454|M.thermoresistible__bu CVAAGVFDLARGAAVACYRARGFRSVAGKGAMALVGLPFEDARQRLGE-- MAB_3148c|M.abscessus_ATCC_199 AVVSEALSLEDGVKVICRRSQLMLRISGAGAMASVDLPAQQVVSELADRD MAV_2370|M.avium_104 AVVAGALSLEDGARVICRRSRLMSRVAGTGATASVELPAQQVLSELTARG MSMEG_6767|M.smegmatis_MC2_155 HHIAGLLTFEQAVHVIYHRSRLQQRTTGQGRMLAVGLDAETLMQILDEKI : : . * *: :* * : * : Mflv_3395|M.gilvum_PYR-GCK ----YPDVTLAVYASPRQTVIAGPPDQVDAVIAAVSAQDRLARRIEVDVA Mvan_3128|M.vanbaalenii_PYR-1 ----YPSVEVAGFVSPRQTVVAGLPEQVDAVIAAVTAQEKFARRVNMEVA Mb2956|M.bovis_AF2122/97 ----FPQVTLGIYNSPRQTVIAGPTEQIDELITRVRARDRFASRVNIEVA Rv2931|M.tuberculosis_H37Rv ----FPQVTLGIYNSPRQTVIAGPTEQIDELIARVRAQNRFASRVNIEVA MLBr_02357|M.leprae_Br4923 ----YSQVTLAIYNSPRQTVIAGPTEQIDELIDRVRAQNRFASRVNIEVA MMAR_1776|M.marinum_M ----YPQVTLGIYNSPRQTVISGPTDQIDELITVVRARDRFATRVNIEVA MUL_2019|M.ulcerans_Agy99 ----YPQVTLGIYNSPRQTVISGPTDQIDELITVVRARDRFATRVNIEVA TH_2454|M.thermoresistible__bu ----RTDVVAAISASPLSTVISGTVDAVGEVSAAWAEQGVMVRKVNTDVA MAB_3148c|M.abscessus_ATCC_199 ----IHDVVLAVVASPQSTVVGGATETVRQLIAEWSDRGLMAREVAVDVA MAV_2370|M.avium_104 ----ISDVVVAVVASPQSTVIAGAAPTVRDLVTAWQERGVMAREVPTDVA MSMEG_6767|M.smegmatis_MC2_155 LDQFGRRVSVAAINSPSAVTVAGDADVLEDIARHLDEAQIFNRYLAVKVP * . ** ..:.* : : : : .*. Mflv_3395|M.gilvum_PYR-GCK SHHPTIDPILPELREALSGLRPVSPNIPIVITTREHDGPE----PVFDAD Mvan_3128|M.vanbaalenii_PYR-1 SHTALMDPVLPDLREALAGVTPRTPNIPFLSTVTEPDG-E----PALDAD Mb2956|M.bovis_AF2122/97 PHNPAMDALQPAMRSELADLTPRTPTIGIISTTYADLHTQ----PVFDAE Rv2931|M.tuberculosis_H37Rv PHNPAMDALQPAMRSELADLTPRTPTIGIISTTYADLHTQ----PVFDAE MLBr_02357|M.leprae_Br4923 PHNPAMDALQPQMRSELADVAPRTPTIPILSTTYADLGSC----PVFDAQ MMAR_1776|M.marinum_M PHNPAMDALQPQMRSELADLAPRTPTIPIISTTYADLGSARESGPTFDAE MUL_2019|M.ulcerans_Agy99 PHNPAMDALQPQMRSELADLAPRTPTIPIISTTYADLGAARESGPTFDAE TH_2454|M.thermoresistible__bu FHSPAMDALTAELARLTSTLTPKPAAVPLYSTALADPRST----AARDEH MAB_3148c|M.abscessus_ATCC_199 SHSPQVDPILDDLADALEDLTPRTPVVPLYSSVSFDPRER----PIMDAD MAV_2370|M.avium_104 FHSPQVDPIMDDLTDALAEISPRPPEVPYYSATLFDPREQ----PVCDAR MSMEG_6767|M.smegmatis_MC2_155 YHTHYMETIKDDLHTAFASLSSKAATLPLYSTVTGELLDR----YDAGAA * ::.: : : . .. : :. . Mflv_3395|M.gilvum_PYR-GCK YWVDNLRNPVRFEQAVAAAGA----EIGTFIEVSPHPLLTYGISDTLG-- Mvan_3128|M.vanbaalenii_PYR-1 YWVANVRQPVKFSQAVTAAAQ----EIGTFIEVSANPILTYAINDTLS-- Mb2956|M.bovis_AF2122/97 HWATNMRNPVHFQQAIASAGSGADGAYHTFIEISAHPLLTQAIIDTLHSA Rv2931|M.tuberculosis_H37Rv HWATNMRNPVRFQQAIASAGSGADGAYHTFIEISAHPLLTQAIIDTLHSA MLBr_02357|M.leprae_Br4923 HWATNMRNPVHFQQAIMTAGT----DHRTFIEISAHPLLTQAITDTLH-- MMAR_1776|M.marinum_M HWAINMRNPVHFQQAITAAAT----DKHNFIEISAHPLLTQAILETLHTV MUL_2019|M.ulcerans_Agy99 HWAINMRNPVHFQQAITAAAT----DKHNFIEISAHPLLTQAILETLHTV TH_2454|M.thermoresistible__bu YWVANLRGRVRFAEAVTAAAEDG---HRLFLEVSAHPVVCHSMAETLALA MAB_3148c|M.abscessus_ATCC_199 YWVDNLRHTVRFAAAVQAALDDG---YRVFGELAPHPLLVYPAEQTARSL MAV_2370|M.avium_104 YWANNMRRMVRFATAVQAALEDG---YRVFAELAPHPLLVRALEQTARSR MSMEG_6767|M.smegmatis_MC2_155 YWWQNTRATVLFEPAMRRMLDDG---YTHFVELGPHPVLAASILESAGTQ :* * * * * *: * *:..:*:: :: Mflv_3395|M.gilvum_PYR-GCK --TSHHHSVPTLLRETGSEGDEASDETLSFHTNLNSTFTTKPPVSDHGPE Mvan_3128|M.vanbaalenii_PYR-1 --SASHVSLGTLARD--------ADDTLTFHTALNATFTGHPPVTPHHGE Mb2956|M.bovis_AF2122/97 QPGARYTSLGTLQRD--------TDDVVTFRTNLNKAHTIHPPHTPHPPE Rv2931|M.tuberculosis_H37Rv QPGARYTSLGTLQRD--------TDDVVTFRTNLNKAHTIHPPHTPHPPE MLBr_02357|M.leprae_Br4923 --GTRCISIGTLQRD--------ADDTVTFHTNLNNVHTVHPPHTPHPAE MMAR_1776|M.marinum_M QPGSKYTSLGTLQRD--------SDDTIVFRTNLNTVRTA-PPQTPHPPE MUL_2019|M.ulcerans_Agy99 QPGSKYTSLGTLQRD--------SDDTIVFRTNLDTVRTA-PPQTPHPPE TH_2454|M.thermoresistible__bu EVGEHAVLPVLRREQP------ELPAVAAVVGALYCHGAPVRPAFPPGTR MAB_3148c|M.abscessus_ATCC_199 DIPMVALAGMRREQE-------LPHGLRDFVGDLYTAGGAVDFSVLYPTG MAV_2370|M.avium_104 EIPMAALAGMRRGQA-------LPHGLRGFVADLHNAGAAVDFSVLYPTG MSMEG_6767|M.smegmatis_MC2_155 RVSVDASQRRGQDDAR---------TLLNCVGALHSRGHEVAWDMVQPRA * Mflv_3395|M.gilvum_PYR-GCK --PHPVLPATPWHHTRHWVAHKKVDRRGPSAPRPGTLLGDLT---SVATS Mvan_3128|M.vanbaalenii_PYR-1 --PHIQLPTTPWHHTHHWAIRKHTAS-GATAPRPGTVLGSHT---AVAGT Mb2956|M.bovis_AF2122/97 --PHPPIPTTPWQHTRHWITTKYPAGSVGSAPRAGTLLGQHTTVATVSAS Rv2931|M.tuberculosis_H37Rv --PHPPIPTTPWQHTRHWITTKYPAGSVGSAPRAGTLLGQHTTVATVSAS MLBr_02357|M.leprae_Br4923 --PHVTIPSTPWQHTRHWIPRKRSVNSIGLAPQVGTLLGQHT---AVSGI MMAR_1776|M.marinum_M --PHPQIPTTPWHHTHHWIDTPAVASRSASTPDKD----------AAGSS MUL_2019|M.ulcerans_Agy99 --PHPQIPTTPWHHTHHWIDTPAVASRSASTPDKD----------AAGSS TH_2454|M.thermoresistible__bu --WATGLPGTQWQHRRFWRTPGTPPGGVGVHDVDSHTLLGGR--IDVAGA MAB_3148c|M.abscessus_ATCC_199 --QLVDVPLPSWTRRSYLLDLSAQAQQGHGTHTVAVHPLLGA-HVRLAEE MAV_2370|M.avium_104 --RLVDAPLPTWTHRRLWLTDGGLESPTHGGCTVAVHPLLGP-HVHLQEE MSMEG_6767|M.smegmatis_MC2_155 GAHPVKLPSYPWQTKRFWNDTHEAEEALFYRPVHPLLGQPVR-------- * * Mflv_3395|M.gilvum_PYR-GCK PPTHLWQARLVRDAKPYPGFHRIQGVEVVPMSVLLRTLAAAAAESG--AS Mvan_3128|M.vanbaalenii_PYR-1 QPGHLWQARLAPQAKPYPQPHKFAGVEIVPLSVLLQTLSLAAAESG--AR Mb2956|M.bovis_AF2122/97 PPSHLWQARLAPDAKPYQGGHRFHQVEVVPASVVLHTILSAATELG--YS Rv2931|M.tuberculosis_H37Rv PPSHLWQARLAPDAKPYQGGHRFHQVEVVPASVVLHTILSAATELG--YS MLBr_02357|M.leprae_Br4923 LPIHLWQARLAPQAKPYRGWHRVHGVEVVPASIVLRTILCAAAELG--YS MMAR_1776|M.marinum_M EPSVSGDSDDAVDSCHYR-------------------------------- MUL_2019|M.ulcerans_Agy99 EPSVSGDSDDAVDSCHYR-------------------------------- TH_2454|M.thermoresistible__bu VPARVWQTRLDLSTRPYPGDHPVQGTEIVPAAVLLNTFLTAAG------S MAB_3148c|M.abscessus_ATCC_199 PERHIWQADVGTVGQPWIADHQVRHVAVYPGAAYCEMALSAAAAVFGEGS MAV_2370|M.avium_104 PERHLWQADVGTAAQPWLADHQIRNVVVLPGAAYCEMALAAARSVLGATA MSMEG_6767|M.smegmatis_MC2_155 AVHPTWEAEFSTLTVPFLADHQVQGSVVVPGAVYVEMALAAGRETYGSDL :: : Mflv_3395|M.gilvum_PYR-GCK ALADIRFDRPVVVDQPQVIQVVAHGDTITMAS---APHADAPANR----- Mvan_3128|M.vanbaalenii_PYR-1 AVADVRFDFPITVDAPRVVQVVSDGETITVSSSTAAAGSDDSAQR----- Mb2956|M.bovis_AF2122/97 ALSEVRFEQPIFADRPRLIQVVADNRAISLAS---SPAAGTPSDR----- Rv2931|M.tuberculosis_H37Rv ALSEVRFEQPIFADRPRLIQVVADNRAISLAS---SPAAGTPSDR----- MLBr_02357|M.leprae_Br4923 TLFEIRFEQPIFANLPRLIQVVVDNQLISLAS---SPATETPQHR----- MMAR_1776|M.marinum_M --------------------VGWPTKPLADAK---ASTETASGTR----- MUL_2019|M.ulcerans_Agy99 --------------------VGWPTKPLADAK---ASTETASGTR----- TH_2454|M.thermoresistible__bu DIADVRLRTPVAPARTRDVQVVLQDRALALASRIVGEDTTARATAGRDTT MAB_3148c|M.abscessus_ATCC_199 AVQSISFEQLLTLGESTPISATATAKSADILEFVVETHDEGDVVKRAT-- MAV_2370|M.avium_104 EVRDIRFEQALLLDEQTTVDASASVSSPGVLHFTVQSHQGGEQARHAS-- MSMEG_6767|M.smegmatis_MC2_155 SVDNLVLHRAVILDDTCDPVIRTTVDQDDGSVEFAALIATADTDLK---- Mflv_3395|M.gilvum_PYR-GCK ----------------------WVRHATARVA-QPRPADTGAVDVTAATD Mvan_3128|M.vanbaalenii_PYR-1 ----------------------WIRHLTARVA-HRVADSPATAGTAQSSG Mb2956|M.bovis_AF2122/97 ----------------------WTRHVTAQLS-SSPSDSASSLNEHHRAN Rv2931|M.tuberculosis_H37Rv ----------------------WTRHVTAQLS-SSPSDSASSLNEHHRAN MLBr_02357|M.leprae_Br4923 ----------------------WTRHVTAQLS-SASARSAVPSDHPDQIN MMAR_1776|M.marinum_M ----------------------WLVFADAELG-AELGLAAG--------- MUL_2019|M.ulcerans_Agy99 ----------------------WLVFADAELG-AELGLAAG--------- TH_2454|M.thermoresistible__bu DRDTTACDTTDRDTTACDDPGVWLTHCTARVA-DDHVGAEGVLDEEAIRA MAB_3148c|M.abscessus_ATCC_199 ----------------------AVLGNGGDVD-MPIAYDLSALRAEHPHR MAV_2370|M.avium_104 ----------------------AVLG-AATDE-QPAAHDLSALLTAHPHD MSMEG_6767|M.smegmatis_MC2_155 ----------------------WVITATAELNTLPRAPRAGDTGGGAVTS . Mflv_3395|M.gilvum_PYR-GCK ---------YDRSTVEELQSRWGVEGQPFPWSIET-------CRATSDGV Mvan_3128|M.vanbaalenii_PYR-1 ---------YDPSALAELHNAWGIDGMAYPWTVAS-------HESAPGEL Mb2956|M.bovis_AF2122/97 GQPPERAHRDLIPDLAELLAMRGIDGLPFSWTVASWT---QHSSNLTVAI Rv2931|M.tuberculosis_H37Rv GQPPERAHRDLIPDLAELLAMRGIDGLPFSWTVASWT---QHSSNLTVAI MLBr_02357|M.leprae_Br4923 G--HLEVISDPIPDVASLLALCGVDGLPFEWSVKSWAKKTQQSTSRTVEI MMAR_1776|M.marinum_M -------------------------------------------AQTRVDV MUL_2019|M.ulcerans_Agy99 -------------------------------------------AQTRVDV TH_2454|M.thermoresistible__bu R----CPQPLPAGHVVDTLAGLGVAAMGFGWEVLELHR--GEGELFARVA MAB_3148c|M.abscessus_ATCC_199 ESGDDLRASFDERGVQYGPAFQGLAAAYRGDETVRSVLAEVTLPRDVRAQ MAV_2370|M.avium_104 DDGDEVRRRMDRRGVQYGPAFAGLGAVHSGDETG-TVLAEVALPRQIRSQ MSMEG_6767|M.smegmatis_MC2_155 TDGDTFYQRTQALGFDYGEAFRSVASVTAGRDWAVAQID---IPQSISAD Mflv_3395|M.gilvum_PYR-GCK LAEVRWQDGSAVALLDAAVQVARLADINDDRLLVPAAVESLTATGELLAS Mvan_3128|M.vanbaalenii_PYR-1 RTVIDLTPGSLVGLLDAAVNLGRLVDSSSPGLMVPSAAESVRFGDDATGT Mb2956|M.bovis_AF2122/97 DLPEALPEGSTGPLLDAAVHLAALSDVADSRLYVPASIEQISLGDVVTGP Rv2931|M.tuberculosis_H37Rv DLPEALPEGSTGPLLDAAVHLAALSDVADSRLYVPASIEQISLGDVVTGP MLBr_02357|M.leprae_Br4923 EFPDTLPDGAIAPLLDAAILIPALADVTETQFYVPASIKQVWLGDTATGP MMAR_1776|M.marinum_M IDPSALTEESE--------LLAALAGVEH--------------------- MUL_2019|M.ulcerans_Agy99 IDPSALTEGSE--------LLAALAGVEH--------------------- TH_2454|M.thermoresistible__bu AEPDKSAPATWAGLIDAATSTASTIFDGPPRLRMPARIERVHVRDKPP-- MAB_3148c|M.abscessus_ATCC_199 QGSYIVHPALLDACFQSVIALPDVQEASKDALPLPKGVRSLHAYESAR-A MAV_2370|M.avium_104 QAAYGAHPALLDACFQSVEAHPAVRALGDGALGLVLGIRRLRAYGAAR-N MSMEG_6767|M.smegmatis_MC2_155 VDTYRFHPALIDGAFQTLFGAPFSGQEENTDPYLPTRIRHCAVYG-PPAE Mflv_3395|M.gilvum_PYR-GCK SGTVTVRRRPGTGEDLVLDVAVTVPDDSTRVDIVGLRYVDVQAG------ Mvan_3128|M.vanbaalenii_PYR-1 GGVITARSRGRDGDDLLVDISIGGAGGAEYAHITGLRYTPVEIGT----- Mb2956|M.bovis_AF2122/97 RSSVTLNRTAHDDDGITVDVTVAAHGEVPSLSMRSLRYRALDFGLDVGRA Rv2931|M.tuberculosis_H37Rv RSSVTLNRTAHDDDGITVDVTVAAHGEVPSLSMRSLRYRALDFGLDVGRA MLBr_02357|M.leprae_Br4923 CGAVTLNRTACDDDGITVDVTVADGSGVPLALMRSLRYRALDLDNAQQDY MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- TH_2454|M.thermoresistible__bu --AIALLHVRRRPEGTVTDVTIAEESGAVSVTLTGMGFEELENPG----- MAB_3148c|M.abscessus_ATCC_199 TQYCYTRVTKVVGNEVEADIDLLDETGSVLIAVRGFRFGTGSSDDEQRDQ MAV_2370|M.avium_104 AHYCYTRVTKADTSGVEADIDVLDEHGAVLLAVQGLRVGTSASESGTRDR MSMEG_6767|M.smegmatis_MC2_155 HMTVRARVLSATHDAVECDITITDPSGGVLAAFDGFTVQSLSASS----- Mflv_3395|M.gilvum_PYR-GCK ------PAEAAPADPRSVAHEIAWRPWTAPSETAPAGASLAVVGS----- Mvan_3128|M.vanbaalenii_PYR-1 ------VTTSAAADPQRVAHRLDWQPWTPAADAGPDTGSVAVIGD----- Mb2956|M.bovis_AF2122/97 QPPASTGPVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAIIG Rv2931|M.tuberculosis_H37Rv QPPASTGPVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAIIG MLBr_02357|M.leprae_Br4923 STVFVESHVDALTDARNFVHAIDWQPRTDLDCSN---TPVASSGSVAVIG MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------GGGSSGDLTGMLHHLRWHPVDWPDTDPPAAVVLVG-------- MAB_3148c|M.abscessus_ATCC_199 LLNNRLLAIEWQQQRLPESVSGAPRRWLLVSTGESVDPWAAELIDSLKVR MAV_2370|M.avium_104 VLTERLLNIEWRQRELPEPEHADAASWLLIGTTATADVLASTLADTLKNH MSMEG_6767|M.smegmatis_MC2_155 ----RMSADHIDKGLFALEWSPVTDTPDTAHGDESTWLILTDNGGVGEAI Mflv_3395|M.gilvum_PYR-GCK ---GTTADALRERLAAAGYTDADEATAQCVLYVP-----GPDGDDLDATV Mvan_3128|M.vanbaalenii_PYR-1 ---DDVAAAVRGAVAANGHAVAEIPDARFVVYVAD---VGDVDSDQDVAV Mb2956|M.bovis_AF2122/97 DDGAALCETLEGAGYQPAVMSDGVSQARYVVYVADSDPAGADETDVDFAV Rv2931|M.tuberculosis_H37Rv DDGAALCETLEGAGYQPAVMSDGVSQARYVVYVADSDPAGADETDVDFAV MLBr_02357|M.leprae_Br4923 DARAGFGLLLKEAGYTLAAPADGVSEVRYVVYVADPHPATTAETDVDFAV MMAR_1776|M.marinum_M -----------------------------VVYAP---PAG-KSLDVNAAY MUL_2019|M.ulcerans_Agy99 -----------------------------VVYAP---PAG-KSLDVNAAY TH_2454|M.thermoresistible__bu ---GDARTRAFVTRDLDEARVAHRSYADPAALPPDLTAGTVVLVLPRTAA MAB_3148c|M.abscessus_ATCC_199 ESEVSLIQWRPNTDRVAALKLLYDQLESGTFDGVLVVTAPGSEGGADRVV MAV_2370|M.avium_104 GAQCTTMAWPQQADHTAHAEQLRNQWRGDGFTGVVVLTGPKNGDNDQESA MSMEG_6767|M.smegmatis_MC2_155 ADGLRLRGHHVHTVAHDPTGEIDWPDMLATHLSGERTGLIDCWPLEVTDA Mflv_3395|M.gilvum_PYR-GCK RLCGEVASLVSRLADRPGTGEPR---LWILTEGVRDADSA-------QSL Mvan_3128|M.vanbaalenii_PYR-1 RLTTEVADLVGTLAERDPRNPAT---LWIVTRGVYESATA-------AAL Mb2956|M.bovis_AF2122/97 RICTEITGLVRTLAERDADKPAA---LWILTRGVHESVAP-------SAL Rv2931|M.tuberculosis_H37Rv RICTEITGLVRTLAERDADKPAA---LWILTRGVHESVAP-------SAL MLBr_02357|M.leprae_Br4923 RITAEISDLVRALAKREPGKPVA---LWIVTRGVYESVAS-------SAL MMAR_1776|M.marinum_M QLFHQVRRLVTVMTK--ASLTAK---LLLVTRNAQPIAEGDR-----ANP MUL_2019|M.ulcerans_Agy99 QLFHQVRRLVAVMTK--ASLTAK---LLLVTRNAQPIAEGDR-----ANP TH_2454|M.thermoresistible__bu RPAASAQLVLHTLQRLSATNSGAR--LWVLTRGVHEGTDP---------- MAB_3148c|M.abscessus_ATCC_199 LQGADQVRHLVRITRELVDLPGEPPRLFVVTRNAQTVVDGDI-----TNL MAV_2370|M.avium_104 LLSRDHVQHLVRIARELTDLPGEPPRLYVVTRNAQTVLPNDV-----PNL MSMEG_6767|M.smegmatis_MC2_155 ATDPAGTATVLRIVKALATLDGVTPRLYLVTANAQPAAGTELTGTELTGV : : * ::* .. Mflv_3395|M.gilvum_PYR-GCK PHSSLWGLAGVVGAEQP-QLWGGLVDVASG-------------------- Mvan_3128|M.vanbaalenii_PYR-1 PQSTLWGLAGVVGAEQP-QLWGGLVDLAG--------------------- Mb2956|M.bovis_AF2122/97 RQSFLWGLAGVIAAEHP-ELWGGLVDLAIN-------------------- Rv2931|M.tuberculosis_H37Rv RQSFLWGLAGVIAAEHP-ELWGGLVDLAIN-------------------- MLBr_02357|M.leprae_Br4923 RQSFLWGFGGVIAAEHP-EMWGGLVDLAASALGA---------------- MMAR_1776|M.marinum_M AHGVLWGLGRTIALEHP-EIWRGIIDLDES-------------------- MUL_2019|M.ulcerans_Agy99 AHGVLWGLGRTIALEHP-EIWRGIIDLDES-------------------- TH_2454|M.thermoresistible__bu GHGPLWGLARVAAAEHP-QLWGGLLDIGED-------------------- MAB_3148c|M.abscessus_ATCC_199 EQAGLRGLVRVIGAEYP-HLRVTHIDVDRHTAAQNVAGELVSGSEEDETA MAV_2370|M.avium_104 GQAGLRGLVRVIGMEHP-QLGAGQIDVDESTDAQALARQLLAGSEEDETA MSMEG_6767|M.smegmatis_MC2_155 EQAAFWGLGRVIGHQELGEYWGGLIDIDHAD------------------- :. : *: . . : . :*: Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 WREDHWYRARLNLGPLGPDDWRSTVATPNNEGVRFEVRTPGDLQSLGFVA MAV_2370|M.avium_104 WRDGAWYTARLCPAPLLPEERHTAVANHECDGMRLQIRTPGDLESLELVA MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 FDRVAPGPGQIEVSVTATSINFADVLNVYGRYSSFEGRQ-ELGVDFAGVV MAV_2370|M.avium_104 CDRIPPGPGQIEVAVSASSINFADVLVAFGRYPAFEGRLPELGTDFAGVV MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------D MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 TAVGEGVTQHQVGDRVGGMTPTGAWRSFVVVDANLAATLPAEVPDREAAA MAV_2370|M.avium_104 TAVGPDVTDHKVGDHVGGLSANGCWGTFLTCDARLAVTLPPGLADDQAAA MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK --ADLDETAKALAGVLPVAAKSILSLRGGEFFAPELAALASDP------- Mvan_3128|M.vanbaalenii_PYR-1 --EDPAGSAEALAALLPTPVKSVAILRDGQLRTSVLAEFTEAP------- Mb2956|M.bovis_AF2122/97 --DDLGEFGPALAELLAKPSKSILVRRDGVVLAPALAPVRGEP------- Rv2931|M.tuberculosis_H37Rv --DDLGEFGPALAELLAKPSKSILVRRDGVVLAPALAPVRGEP------- MLBr_02357|M.leprae_Br4923 RDDILDQFGPTLASLLQTPTRSIVVLRDGVVLAPTLVPIRSEP------- MMAR_1776|M.marinum_M -MPAELAAPKILGEVTGTDGEDQVVYRCGGRHVPRLQ-RRTAP------- MUL_2019|M.ulcerans_Agy99 -MPAELAAPKILGEVTGTDGEDQVVYRCGSRHVPRLQ-RRTAP------- TH_2454|M.thermoresistible__bu --------RLPVRALTALTGHGVVVVRDGVAHTARLAPAGPGAR------ MAB_3148c|M.abscessus_ATCC_199 VPGAHVTAWYGLHELARISAGDKVLIHSGTGGVGQAAIAIARAAGAEIYA MAV_2370|M.avium_104 VTTAHATAYYGLHELARIGAGDRVLIHSATGGVGQAAIAIARAAGAEIFA MSMEG_6767|M.smegmatis_MC2_155 --APSSTAEQICGHVLGDGAEDQIALRGNQILAPRLRPCSGLT------- : . : . . Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 TAGSPERRDLLRSWGIKHVYDSRSTDFAELIRRDTDGYGVDIVLNSLTGA MAV_2370|M.avium_104 TAGSEQRRQLLRDMGIEHVYDSRTVEFADLIRHDTDGYGVDIVLNSVTGA MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 AQRAGVELLTFGGRFIEIGKRDIYGDTRLGLFPFRRNLSFHAVDLVLVAK MAV_2370|M.avium_104 AQRAGIELLAFGGRFVEIGKRDIYGDTRLGLLPFRRNLTFYALDLALMSF MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MAB_3148c|M.abscessus_ATCC_199 TRPEAIYRTLTALYGQMAEGVLPLPEISPSPLQEAAESIRVMGAAGHTGK MAV_2370|M.avium_104 SHPDRLRGLLRTVYRLTADGALPMPESTHYPLADAASAIRVMSAAQHTGK MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK ----------------VREPLRCRPDAAYLITGGLGALGLVTAEWLADRG Mvan_3128|M.vanbaalenii_PYR-1 ----------------ARETLRCRPDAAYLITGGMGVLGLLMADWLADRG Mb2956|M.bovis_AF2122/97 ----------------ARKSLQCRPDAAYLITGGLGALGLLMADWLADRG Rv2931|M.tuberculosis_H37Rv ----------------ARKSLQCRPDAAYLITGGLGALGLLMADWLADRG MLBr_02357|M.leprae_Br4923 ----------------VRKSLQCKSDGAYLITGGMGALGLLMADWLADRG MMAR_1776|M.marinum_M ----------------AVAPVTLDPNSSQLVIGATGNIGPYLIRQLAQMG MUL_2019|M.ulcerans_Agy99 ----------------AVAPVTLDPNSSQLVIGATGNIGPYLIRQLAQMG TH_2454|M.thermoresistible__bu --------------DSAGEGLRCSPGGTYLITGGTGALGLRLAHRLADLG MAB_3148c|M.abscessus_ATCC_199 LVLDLPKAGEVSAVIPPSHAPAFRRDGAYVVTGGLGGLGLFLARKLAAAG MAV_2370|M.avium_104 LVLDVPHAGRSRVVVPPAQVRAFRSDGAYIVTGGLGGLGLFLAEKMASPG MSMEG_6767|M.smegmatis_MC2_155 ----------------KPFPTKLTADATYVVTGGAGALGRVVATYLAERG ..: :: *. * :* :* * Mflv_3395|M.gilvum_PYR-GCK ----ARRVVLAGRTALPPRRRWDDDDLDKDARDKIAAVRALELRGVAVEL Mvan_3128|M.vanbaalenii_PYR-1 ----ARRVVLAGRTPLPPRRDWDDESIDADTRHKIAAIRALELRGVSVDT Mb2956|M.bovis_AF2122/97 ----AHRLVLTGRTPLPPRRDWQLDTLDTELRRRIDAIRALEMRGVTVEA Rv2931|M.tuberculosis_H37Rv ----AHRLVLTGRTPLPPRRDWQLDTLDTELRRRIDAIRALEMRGVTVEA MLBr_02357|M.leprae_Br4923 ----ARRLVLMGRTPLPPRRDWELDTLDAGLRQKIDAICALEMRGVTVEA MMAR_1776|M.marinum_M ----AKTVVAVSRNPG---------------QRLQELAESLAAEGTNLVI MUL_2019|M.ulcerans_Agy99 ----AKTVVAVSRNPG---------------QRLQELAESLAAEGTNLVI TH_2454|M.thermoresistible__bu ----ARRLVLVSRSGMPARDSWG----RAGDSDTVAAITALEERGVSVRV MAB_3148c|M.abscessus_ATCC_199 ----VGRIILNGRSAPKP--------------EALAAIEQIRQGGTEIDV MAV_2370|M.avium_104 SRAGCGRIVLCSRALPNP--------------KALATLERIRQMGADIVV MSMEG_6767|M.smegmatis_MC2_155 ----ARHITLLGRSPISPRDRWASITEDDAHHATVDAIRAIERLGAHVST : .* : *. : Mflv_3395|M.gilvum_PYR-GCK APVDIGSRDAVEALLTRRDEQGAPPIRGVIHGAGLTDSQLLTDIDDERLR Mvan_3128|M.vanbaalenii_PYR-1 VALDVGSREALTAVLDKRDGDGAPPIRGVIHAAGMTEAQLLTEIEADRVH Mb2956|M.bovis_AF2122/97 VAADVGCREDVQALLAARDRDGAAPIRGIIHAAGITNDQLVTSMTGDAVR Rv2931|M.tuberculosis_H37Rv VAADVGCREDVQALLAARDRDGAAPIRGIIHAAGITNDQLVTSMTGDAVR MLBr_02357|M.leprae_Br4923 VAVDVGHHDDVQALLAKRDRDGAAPIRGIIHAAGVTNDQLVTNMTDDPVR MMAR_1776|M.marinum_M EAADATDEAAMTALFDRFGAD-LPPLEGIYLAAFAGGPVLLNEMTDADVR MUL_2019|M.ulcerans_Agy99 EAADATDEAAMTALFDRFGAD-LPPLDGIYLAAFAGGPVLLNEMTDADVR TH_2454|M.thermoresistible__bu AALDIGAPGAAARLR--EVLADLPDVRGVIHAAGVEAGALLTNTTAEDIE MAB_3148c|M.abscessus_ATCC_199 ALGDIAEPDTAQRLVAAATETGKPVRGVLHAAALVHDATLANITDELIDR MAV_2370|M.avium_104 ERGDIAEAGTAQRLLDVATATGLPVRGVLHLAAVIEDATLANITDELIER MSMEG_6767|M.smegmatis_MC2_155 ASVDITDSDQVRAWLREHTGSGGRPVRGIVHAAGSVRDQLLVNMGEDDFA * : .* * Mflv_3395|M.gilvum_PYR-GCK RTLWPKVAGARVLH----ELFPTDSVDFLYLTASAGTVFGVPGQGAYAAG Mvan_3128|M.vanbaalenii_PYR-1 RTVWPKIAGAKVLD----ELFPPGSLDFLYLAASAGAVFGIPGQGAYAAG Mb2956|M.bovis_AF2122/97 QVMWPKIGGSQVLH----DAFPPGSVDFFYLTASAAGIFGIPGQGSYAAA Rv2931|M.tuberculosis_H37Rv QVMWPKIGGSQVLH----DAFPPGSVDFFYLTASAAGIFGIPGQGSYAAA MLBr_02357|M.leprae_Br4923 QVMWPKIAGCQVLH----EAFPPGSVDFFYLTSSAAGIFGIPGQGSYAAA MMAR_1776|M.marinum_M AMFAPKLDAAALLH----RLSLKVPARHFVLFSSISGLIGSRWLAHYTAT MUL_2019|M.ulcerans_Agy99 AMFAPKLDAAALLH----RLSLKVPARHFVLFSSISGLIGSRWLAHYTAT TH_2454|M.thermoresistible__bu ATMRPKVDGVLALH----EVFPPGRLDWLVLFSSCGYLGGFPGQGAYACG MAB_3148c|M.abscessus_ATCC_199 GDWRPKVHGAWNLH----EATADQPLDWFCSFSSIAALVGSPGQGAYAAA MAV_2370|M.avium_104 -DWAAKVYGAWNLHCALQESGAEQSLDWFCSFSSAAALVGSPGQGAYAAA MSMEG_6767|M.smegmatis_MC2_155 EVLAPKITGTRVLHN----VFEDHDLEFFVMFGSAGSTIAAPGQGNYAAA .*: . *. : .* . . . *:. Mflv_3395|M.gilvum_PYR-GCK NAYLDGLARARRREGGVTASLDWVAWRGLG---FGSDAQVVIDELERQGS Mvan_3128|M.vanbaalenii_PYR-1 NAYLDALARSRHHRGDNTVSLDWVAWQGLG---FGSEAQVVVSELERVGS Mb2956|M.bovis_AF2122/97 NSYLDALARARRQQGCHTMSLDWVAWRGLG---LAADAQLVSEELARMGS Rv2931|M.tuberculosis_H37Rv NSYLDALARARRQQGCHTMSLDWVAWRGLG---LAADAQLVSEELARMGS MLBr_02357|M.leprae_Br4923 NSYLDALARTRRQQGCHTMSIDWVAWRGLG---FAANAQIVSDELQRMGS MMAR_1776|M.marinum_M SGYLDALAYARHALGLPATTVNWGLWKSLADAEHDASQVSVGSGLLPMQD MUL_2019|M.ulcerans_Agy99 SGYLDALAYARHALGLPATTVNWGLWKSLADAEHDASQVSVGSGLLPMQD TH_2454|M.thermoresistible__bu NAYLDAFARYRRASGDATTSVAWTAWRGLG---MGSASDFVAAQLDALGM MAB_3148c|M.abscessus_ATCC_199 NSWLDGFTHWRRAQGLPATVIAWGAWSEIG----------QGTHLAQNAE MAV_2370|M.avium_104 NSWLDAFTRWRRARGLKATAIAWGAWAQIG----------RGAALADSAD MSMEG_6767|M.smegmatis_MC2_155 NAFLDAFAHHRQGLGLPALTIGWGPWSVGM-----VEELGLEKVYAQRGI ..:**.:: *: * : : * * Mflv_3395|M.gilvum_PYR-GCK RPVTPAEAFAAWEYASRFDVAHVVMAPTLDADEDTD-----------QAA Mvan_3128|M.vanbaalenii_PYR-1 RPVVPAEAFAAWDFVTRFDVAQVVMAPMQSAEDAAA-----------VTA Mb2956|M.bovis_AF2122/97 RDITPSEAFTAWEFVDGYDVAQAVVVPMPAPAGADG----------SGA- Rv2931|M.tuberculosis_H37Rv RDITPSEAFTAWEFVDGYDVAQAVVVPMPAPAGADG----------SGA- MLBr_02357|M.leprae_Br4923 RDITPSEAFTAWEYVDAYDVAQAVVLPVPRSYGSAG----------STAG MMAR_1776|M.marinum_M EVAIGTLPLLMNPAAGVHSVVVEADWPLLAAAYRTRGSLHIVDDLLRDFA MUL_2019|M.ulcerans_Agy99 EVAIGTLPLLMNPAAGVHSVVVEADWPLLAAAYRTRWSLHIVDDLLRDFA TH_2454|M.thermoresistible__bu GTVDVDDAMRALDAAIRDGDPNVVVLPLSPAAAAVPMFADVAPADPDADA MAB_3148c|M.abscessus_ATCC_199 AAILPDEGAYAFDTVLRHNRAYTAYAPMAGISWLADFVER------SPFA MAV_2370|M.avium_104 VAITPDEGAYAFEALLRHDRACTGYAPITGTPWLTAFAQR------SPFA MSMEG_6767|M.smegmatis_MC2_155 ELITPAVGARIIDRLLSQSVPAVVAMNADWSRARQVGFGGLVPKMFGELG . Mflv_3395|M.gilvum_PYR-GCK ESG--PERDWSQMSAD---------DVVSELESGLRTILAVELRIGDD-E Mvan_3128|M.vanbaalenii_PYR-1 DTHRAPTRDWTAMAPD---------ELLAELQDGLRGILATELRLPES-D Mb2956|M.bovis_AF2122/97 NAYLLPARNWSVMAAT---------EVRSELEQGLRRIIAAELRVPEK-E Rv2931|M.tuberculosis_H37Rv NAYLLPARNWSVMAAT---------EVRSELEQGLRRIIAAELRVPEK-E MLBr_02357|M.leprae_Br4923 DSYLVPARNWSQMEAA---------EVRKELESGLRTIIAAELRVAEA-E MMAR_1776|M.marinum_M EASTIPARDWSHLSAQ---------EVRTEFEAGLRRIVARELRVSES-D MUL_2019|M.ulcerans_Agy99 EASTIPARDWSHLSAQ---------EVRTEFEAGLRRIVARELRVSES-D TH_2454|M.thermoresistible__bu PGGEVPDGLSDGFPADGFPDD---GDLAEWVHRRVIAAVAGELGLAET-D MAB_3148c|M.abscessus_ATCC_199 QAFRDAGQNQTETNKFLDELR---ALPREEWPTRLRKLVAEQVGLVLRRS MAV_2370|M.avium_104 EAFRANGQSATGTSKLRAELE---ELPPEEWSTRLRRLISDQVSLILRRN MSMEG_6767|M.smegmatis_MC2_155 TADTVGGQDGVGPSILELLAHTADADRPAVIAEQVRRLVAAVFDCAVT-D : :: . . Mflv_3395|M.gilvum_PYR-GCK VDSDRPLAEMGLNSVMAMSIRREVEKLAGIELSATMLWNYPTIGALAAYL Mvan_3128|M.vanbaalenii_PYR-1 VHTDRPFAEMGLNSVMAMSIRREVERLVGLELSATMLFNHPTIESFASYL Mb2956|M.bovis_AF2122/97 LDTDRPFAELGLNSLMAMAIRREAEQFVGIELSATMLFNHPTVKSLASYL Rv2931|M.tuberculosis_H37Rv LDTDRPFAELGLNSLMAMAIRREAEQFVGIELSATMLFNHPTVKSLASYL MLBr_02357|M.leprae_Br4923 LDTDRPFAELGLNSLMAMAIRREAEQFIGIELSAIMLFNHPTVALLAAYL MMAR_1776|M.marinum_M LETDRPLAELGLNSLMAMAIRREAEMFVGIELSATMLFNHPTVASLASYL MUL_2019|M.ulcerans_Agy99 LETDRPLAELGLNSLMAMAIRREAEMFVGIELSATMLFNHPTVASLASYL TH_2454|M.thermoresistible__bu VDPRLPLVEIGVDSIMTVALRRQLERQTGLTLPPTLLWEHPTAGAVSDRI MAB_3148c|M.abscessus_ATCC_199 IDPDRSLPDYGLDSLGNLEIRTRIQADTGVRIGPADVS---TVRSLAAHI MAV_2370|M.avium_104 VDPDRPLPEYGLDSLGGLELLTRIQTETGIRVSPADIAAIGTIRGLADLL MSMEG_6767|M.smegmatis_MC2_155 IEPDDMLDDIGLDSMMAMDFRVRINSAFSIDLPVLEILRGVSVNSLSARI :.. : : *::*: : : . : .: : : : .: : Mflv_3395|M.gilvum_PYR-GCK AEKVAPQ-----------------AVA----EAAEEDSGDSLLDSLFDSV Mvan_3128|M.vanbaalenii_PYR-1 AQQLAPE-----------------TGGD---DEVADDSGGSLLDSLFDSV Mb2956|M.bovis_AF2122/97 AKRVAPH-----------------DVSQDNQISALSSSAGSVLDSLFDRI Rv2931|M.tuberculosis_H37Rv AKRVAPH-----------------DVSQDNQISALSSSAGSVLDSLFDRI MLBr_02357|M.leprae_Br4923 TKVVAPQ-----------------HDSQGDEMAALSASAGGVLDSLFDRI MMAR_1776|M.marinum_M ANRVAPQ-----------------DNSSNDQMAELSASAGSTLDSLFDRI MUL_2019|M.ulcerans_Agy99 ANRVAPQ-----------------DNSSNDQMAELSASAGSTLDSLFDRI TH_2454|M.thermoresistible__bu VEMLRAR-----------------G------------------------- MAB_3148c|M.abscessus_ATCC_199 YDRLAEQ-----------------ESEVASS------------------- MAV_2370|M.avium_104 RDKLTPA-----------------GAAQAERV------------------ MSMEG_6767|M.smegmatis_MC2_155 LAELRDIHGVAPVEPDTGETASEPTTTDDDVERLLQDLSEAEMRQLLAEL : Mflv_3395|M.gilvum_PYR-GCK EN---------- Mvan_3128|M.vanbaalenii_PYR-1 EN---------- Mb2956|M.bovis_AF2122/97 ESAPPEAERSV- Rv2931|M.tuberculosis_H37Rv ESAPPEAERSV- MLBr_02357|M.leprae_Br4923 ESTSTEAEGLV- MMAR_1776|M.marinum_M ESSSLLPEGPG- MUL_2019|M.ulcerans_Agy99 ESSSLLPEGPG- TH_2454|M.thermoresistible__bu ------------ MAB_3148c|M.abscessus_ATCC_199 ------------ MAV_2370|M.avium_104 ------------ MSMEG_6767|M.smegmatis_MC2_155 EASGTEAGGAIS