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M. leprae Br4923 MLBr_02357 (-)

annotation: polyketide synthase
coordinates: 2815992 - 2821607
length: 1871

TASIGSEADLCHWLVNYLVTNIGCTPDEVDLNLSLTDLGMSSRDAVVLSGELTDLLGKTVSPIDFWEHPT
INALAAYLIAPAPDPESESAPRRSVQGALEEPIAVIGMGCRFPGGISGPEALWQFLCDRRSSIGQVPNER
WELFDDGSPEVKALLARTTRWGSFLEDIDAFDSEFFEISPSEADKMDPQQRLLLEVAWEALEHAGISSNS
LRRSQTGVFAGSCLSEYGAIASTDLSQVDGWSNTGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIH
LACQSLRTADANLAIAAGVNLLLSPAVFRGFDQVGALSPTGCCRAFDAAADGFVRGEGAGVVVLKRLTDA
QRDGDRVLAIIRGSAVNQDGRSNGLMAPNPAAQVAVLRTAYANAAMPPTAIDYVETHGTGTLLGDPIEAR
ALGAVLGRGRAEDSPLLIGAVKTNLGHLEAAAGIAGFIKTVLAVQRGQIPPNQRFESPNLHIPFAELRMK
VVDKHMEWPDTGHLRRAAVSSFGFGGTNAHVVIEQGPELTPVTECSSNTAVSTLVVTGKTASRVAAMAGM
LADWVEGPGAEVALADVAHTLNHHRSRHAKFGTVVARDRIQAVAGLRALAAGKQAPGVVGQQDGTPGSGT
VFVYSGRGSQWAGMGRQLLADEPAFTAAVAELEPVFVVHAGFSLHDVLANGKELVGIEQIQLGLIGMQLT
LTELWRSYGVQPDLVIGHSLGEVAAAVVAGALTAAEGLRVTATRSRLMAPLSGQGGMALLELDAVETEAL
IVDYSQVTLAIYNSPRQTVIAGPTEQIDELIDRVRAQNRFASRVNIEVAPHNPAMDALQPQMRSELADVA
PRTPTIPILSTTYADLGSCPVFDAQHWATNMRNPVHFQQAIMTAGTDHRTFIEISAHPLLTQAITDTLHG
TRCISIGTLQRDADDTVTFHTNLNNVHTVHPPHTPHPAEPHVTIPSTPWQHTRHWIPRKRSVNSIGLAPQ
VGTLLGQHTAVSGILPIHLWQARLAPQAKPYRGWHRVHGVEVVPASIVLRTILCAAAELGYSTLFEIRFE
QPIFANLPRLIQVVVDNQLISLASSPATETPQHRWTRHVTAQLSSASARSAVPSDHPDQINGHLEVISDP
IPDVASLLALCGVDGLPFEWSVKSWAKKTQQSTSRTVEIEFPDTLPDGAIAPLLDAAILIPALADVTETQ
FYVPASIKQVWLGDTATGPCGAVTLNRTACDDDGITVDVTVADGSGVPLALMRSLRYRALDLDNAQQDYS
TVFVESHVDALTDARNFVHAIDWQPRTDLDCSNTPVASSGSVAVIGDARAGFGLLLKEAGYTLAAPADGV
SEVRYVVYVADPHPATTAETDVDFAVRITAEISDLVRALAKREPGKPVALWIVTRGVYESVASSALRQSF
LWGFGGVIAAEHPEMWGGLVDLAASALGADRDDILDQFGPTLASLLQTPTRSIVVLRDGVVLAPTLVPIR
SEPVRKSLQCKSDGAYLITGGMGALGLLMADWLADRGARRLVLMGRTPLPPRRDWELDTLDAGLRQKIDA
ICALEMRGVTVEAVAVDVGHHDDVQALLAKRDRDGAAPIRGIIHAAGVTNDQLVTNMTDDPVRQVMWPKI
AGCQVLHEAFPPGSVDFFYLTSSAAGIFGIPGQGSYAAANSYLDALARTRRQQGCHTMSIDWVAWRGLGF
AANAQIVSDELQRMGSRDITPSEAFTAWEYVDAYDVAQAVVLPVPRSYGSAGSTAGDSYLVPARNWSQME
AAEVRKELESGLRTIIAAELRVAEAELDTDRPFAELGLNSLMAMAIRREAEQFIGIELSAIMLFNHPTVA
LLAAYLTKVVAPQHDSQGDEMAALSASAGGVLDSLFDRIESTSTEAEGLV*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_02357--100% (1871)polyketide synthase
M. leprae Br4923MLBr_02356-0.079.93% (872) polyketide synthase
M. leprae Br4923MLBr_02355-0.047.74% (1481) polyketide synthase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2956ppsA0.075.85% (1888) phenolpthiocerol synthesis type-I polyketide synthase PPSA
M. gilvum PYR-GCKMflv_3395-0.053.77% (1882) acyl transferase domain-containing protein
M. tuberculosis H37RvRv2931ppsA0.075.95% (1888) phenolpthiocerol synthesis type-I polyketide synthase PPSA
M. abscessus ATCC 19977MAB_3148c-1e-17632.19% (1370) polyketide synthase Pks5
M. marinum MMMAR_1776ppsA0.081.04% (1002) phenolpthiocerol synthesis type-I polyketide synthase PpsA
M. avium 104MAV_2370-0.033.86% (1382) mycocerosic acid synthase
M. smegmatis MC2 155MSMEG_6767-0.031.45% (1879) mycocerosic acid synthase
M. thermoresistible (build 8)TH_2454-0.035.61% (1814) PUTATIVE beta-ketoacyl synthase
M. ulcerans Agy99MUL_2019ppsA0.080.94% (1002) phenolpthiocerol synthesis type-I polyketide synthase PpsA
M. vanbaalenii PYR-1Mvan_3128-0.055.48% (1878) beta-ketoacyl synthase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3395|M.gilvum_PYR-GCK          MTSAFD-EDAIRNWLVDYLVTNIGCSPDEIDFDAPLNDLAVGSSDAVVLT
Mvan_3128|M.vanbaalenii_PYR-1       MTSAFD-EDAIRNWLVDYLVTNIGCSPDEINFDAPLNDLAVGSSDAVVLT
Mb2956|M.bovis_AF2122/97            MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLADLGVSSRDAVVLS
Rv2931|M.tuberculosis_H37Rv         MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLADLGVSSRDAVVLS
MLBr_02357|M.leprae_Br4923          MTASIGSEADLCHWLVNYLVTNIGCTPDEVDLNLSLTDLGMSSRDAVVLS
MMAR_1776|M.marinum_M               MTPSIGGEADLRHWLVDYLVTNIGCPPDEVDPNLSLADLGVSSRDAVVLS
MUL_2019|M.ulcerans_Agy99           MTPSIGGEADLRHWLVDYLVTNIGCPPDEVDPNLSLADLGVSSRDAVVLS
TH_2454|M.thermoresistible__bu      --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_2370|M.avium_104                --------------------------------------------------
MSMEG_6767|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          GELSELLGRTVSPVEFWQYPTINALARFLTGGEVEAVAEVSPIRRVS---
Mvan_3128|M.vanbaalenii_PYR-1       GELSELLGRTVSPVEFWQYPTINALAKFLTGGEVEPAIEASVGGGVSRDY
Mb2956|M.bovis_AF2122/97            GELSELLGRTVSPIDFWEHPTINALAAYLAAPEPSPDSDAAVKRGAR---
Rv2931|M.tuberculosis_H37Rv         GELSELLGRTVSPIDFWEHPTINALAAYLAAPEPSPDSDAAVKRGAR---
MLBr_02357|M.leprae_Br4923          GELTDLLGKTVSPIDFWEHPTINALAAYLIAPAPDPESESAPRRSVQ---
MMAR_1776|M.marinum_M               GELTELLGRTVSPIDFWEHPTINDLAAYLTAPEPSTGAEAAVSRTVR---
MUL_2019|M.ulcerans_Agy99           GELTELLGRTVSPIDFWEHPTINDLAAYLTAPEPSTGAEAAVSRTVR---
TH_2454|M.thermoresistible__bu      -------------------------------------MSVDVTAKAR---
MAB_3148c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_2370|M.avium_104                --------------------------------------------------
MSMEG_6767|M.smegmatis_MC2_155      -------------------------------------MPMPNTDHTS---
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          ---DDAIAVVGLGVRFPGGG---DDIHGPDDLWEFLAQGRSAVSQVPPTR
Mvan_3128|M.vanbaalenii_PYR-1       GADDEPIAVIGLGCRFPGGDGLDGNITGPDAYWRFLMEGRSAVRQVPEER
Mb2956|M.bovis_AF2122/97            NSLDEPIAVVGMGCRFPGG------ISCPEALWDFLCERRSSISQVPPQR
Rv2931|M.tuberculosis_H37Rv         NSLDEPIAVVGMGCRFPGG------ISCPEALWDFLCERRSSISQVPPQR
MLBr_02357|M.leprae_Br4923          GALEEPIAVIGMGCRFPGG------ISGPEALWQFLCDRRSSIGQVPNER
MMAR_1776|M.marinum_M               GSLEEPIAVVGMGCRFPGG------ISGPEALWQFLCDRKSSIGRVPDER
MUL_2019|M.ulcerans_Agy99           GSLEEPIAVVGMGCRFPGG------ISGPEALWQFLCDRKSSIGRVPDER
TH_2454|M.thermoresistible__bu      --PDDPIAIIGIGCRLAGR------ITSPEEFWGFLLAGGSNVREIPAER
MAB_3148c|M.abscessus_ATCC_199      -----------MGCRLPGG------IESPEQFWQALLRGEDFITEVPPAR
MAV_2370|M.avium_104                ---MVPVAVIGMACRLPGA------VDSPERLWEALLRGDDFVTEIPPDR
MSMEG_6767|M.smegmatis_MC2_155      ---RQPLAIVGIGCRFPGG------ADSAQRYWDLLCNNIDATREVPENR
                                               :. *:.*          .:  *  *    .   .:*  *

Mflv_3395|M.gilvum_PYR-GCK          WSWYDDGSPEGAAALAHTTRWGSYLSEIDEFDADYFEISPSEADKMDPQQ
Mvan_3128|M.vanbaalenii_PYR-1       WESFQINTPEAAAALAGTTRWGAFLRDLDAFDAEFFEISPSEADKMDPQQ
Mb2956|M.bovis_AF2122/97            WQPFEGGPPEVAAALARTTRWGSFLPDIDAFDAEFFEISPSEADKMDPQQ
Rv2931|M.tuberculosis_H37Rv         WQPFEGGPPEVAAALARTTRWGSFLPDIDAFDAEFFEISPSEADKMDPQQ
MLBr_02357|M.leprae_Br4923          WELFDDGSPEVKALLARTTRWGSFLEDIDAFDSEFFEISPSEADKMDPQQ
MMAR_1776|M.marinum_M               WAQFDDGSPAVKALLARTTRWGSYLTDIDAFDADFFEISASEADKMDPQQ
MUL_2019|M.ulcerans_Agy99           WAQFDDGSPAVKALLARTTRWGSYLTDIDAFDADFFEISASEADKMDPQQ
TH_2454|M.thermoresistible__bu      WEPYLRRDPRNAAVLREITPWGTFLDDLAGFDAEFFGVSPREAELTDPQQ
MAB_3148c|M.abscessus_ATCC_199      WDLTEYYDPESGVPGKSPSKWGAFLEDVGGFDADFFSINEREAVSIDPQH
MAV_2370|M.avium_104                WDADEYYDPEPGVPGRSVSRWGAFIDDVAGFDPEFFGINEREATAMDPQH
MSMEG_6767|M.smegmatis_MC2_155      WNAAKYHDPNPAKIGKIVTRRGGFLDQIDQFDPQFFGISPREAHSLDPQQ
                                    *       *         :  * :: ::  **.::* :.  **   ***:

Mflv_3395|M.gilvum_PYR-GCK          RLLLEVTHEALEHAGIRPDVLRHTQTGVFVGACLGEYAVMASKDLA---E
Mvan_3128|M.vanbaalenii_PYR-1       RLLLEVTQEALEHAGIPTHTLRHSQTGVFAAACLGEYGYLSTVDLG---D
Mb2956|M.bovis_AF2122/97            RLLLEVAWEALEHAGIPPGTLRRSATGVFAGACLSEYGAMASADLS---Q
Rv2931|M.tuberculosis_H37Rv         RLLLEVAWEALEHAGIPPGTLRRSATGVFAGACLSEYGAMASADLS---Q
MLBr_02357|M.leprae_Br4923          RLLLEVAWEALEHAGISSNSLRRSQTGVFAGSCLSEYGAIASTDLS---Q
MMAR_1776|M.marinum_M               RLLLEVAWEALEHAGIPPSSLRRSQTGVFAGSCLSEYGAIASTDLT---Q
MUL_2019|M.ulcerans_Agy99           RLLLEVAWEALEHAGIPPSSLRRSQTGVFAGSCLSEYGAIASTDLT---Q
TH_2454|M.thermoresistible__bu      RLALEVSWEALEHAGVPPRSLAGTDTAVLMGVNSDDYGRLLMEDLP---G
MAB_3148c|M.abscessus_ATCC_199      RVLLETSWQAVEHAGIDPRALAGSQTGVFVGVTHNDYQLVAADAAD---L
MAV_2370|M.avium_104                RLLLETSWEAMEHAGLTEERVADSRTGVFIGLTHGDYQLLAADTRS---V
MSMEG_6767|M.smegmatis_MC2_155      RLLLQATWEALEDGGIPADELAGTDVGVFVGGFTLDYQLLQNQGRTSRYR
                                    *: *:.: :*:*..*:    :  : ..*: .    :*  :          

Mflv_3395|M.gilvum_PYR-GCK          VNAYSGTGGALSIIANRVSYFYDLRGPSVTIDTACSSSLVAIHLACQSLR
Mvan_3128|M.vanbaalenii_PYR-1       VDSWSGTGGALSIIANRVSYYFDLRGPSVTIDTACSSSLVTIHLACQSLR
Mb2956|M.bovis_AF2122/97            VDGWSNSGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLR
Rv2931|M.tuberculosis_H37Rv         VDGWSNSGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLR
MLBr_02357|M.leprae_Br4923          VDGWSNTGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLR
MMAR_1776|M.marinum_M               VDGWSNTGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLR
MUL_2019|M.ulcerans_Agy99           VDGWSNTGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLR
TH_2454|M.thermoresistible__bu      IEAWTGIGTSLCGIANRVSHLLDLRGPSVALDAACAASLVAVHNACQLLR
MAB_3148c|M.abscessus_ATCC_199      GGPYGFAGTNFCMASGRISYALGVHGPSLTVDAGCAAGLATVHMGCQSLA
MAV_2370|M.avium_104                EGAYGFSGSNFSLASGRIAYALGVHGPALTVDTACSSGLTAIHLACRSLH
MSMEG_6767|M.smegmatis_MC2_155      FKPHSATGMMMTMLANRISHAFDFRGPSMAIDTACSSSLVAVHLAAQSIW
                                           *  :   :.*:::  ..:**::::*:.*::.*.::* ..: : 

Mflv_3395|M.gilvum_PYR-GCK          SGDSDVALAGGVNVILSPAVTRSFDQAEAMSKSGRCHAFDSRADGFVRGE
Mvan_3128|M.vanbaalenii_PYR-1       SGDSNMALAAGVNLLLSPAVTRSFDQLEAMSRTGQCHAFDAGADGFVRGE
Mb2956|M.bovis_AF2122/97            TQDCHLAIAAGVNLLLSPAVFRGFDQVGALSPTGQCRAFDATADGFVRGE
Rv2931|M.tuberculosis_H37Rv         TQDCHLAIAAGVNLLLSPAVFRGFDQVGALSPTGQCRAFDATADGFVRGE
MLBr_02357|M.leprae_Br4923          TADANLAIAAGVNLLLSPAVFRGFDQVGALSPTGCCRAFDAAADGFVRGE
MMAR_1776|M.marinum_M               MQDSNLAIAAGVNLLLSPAVFRGFDQVGALSPTGNCRAFDAAADGFVRGE
MUL_2019|M.ulcerans_Agy99           MQDSNLAIAAGVNLLLSPAVFRGFDQVGALSPTGNCRAFDAAADGFVRGE
TH_2454|M.thermoresistible__bu      AGETGLAIAGGVSALIGPGLTRVLDKAGATAPDGRCKSFDASADGYGRGE
MAB_3148c|M.abscessus_ATCC_199      AGESDLVLAGGVNLVLEPRRYVGASQQRMLSPTGRCHTFTGEADGFVMSE
MAV_2370|M.avium_104                EGESDLALAGGATLALDPRKFSAGSAEGMLSPTGRCHAFDVAADGFVGGE
MSMEG_6767|M.smegmatis_MC2_155      DGDCDVALAGGVNIMVGPNTAIAESKSGFLSPEGRSKAFSDTADGYARGE
                                      :  :.:*.*..  : *      .     :  * .::*   ***:  .*

Mflv_3395|M.gilvum_PYR-GCK          GCGVAVLKRLSDAQRDGDRVLAVVRGSAVNQDGRSNGLMAPNPAAQMSVL
Mvan_3128|M.vanbaalenii_PYR-1       GCGVTVLKRLSDAQRDGDRILAVIRGSAVNQDGRSNGLMAPNPAAQMAVL
Mb2956|M.bovis_AF2122/97            GAGVVVLKRLTDAQRDGDRVLAVICGSAVTQDGRSNGLMAPNPAAQMAVL
Rv2931|M.tuberculosis_H37Rv         GAGVVVLKRLTDAQRDGDRVLAVICGSAVNQDGRSNGLMAPNPAAQMAVL
MLBr_02357|M.leprae_Br4923          GAGVVVLKRLTDAQRDGDRVLAIIRGSAVNQDGRSNGLMAPNPAAQVAVL
MMAR_1776|M.marinum_M               GAGVVVLKRLTDAQQDGDRVLAVICGSAINQDGRSNGLMAPNPAAQQAVL
MUL_2019|M.ulcerans_Agy99           GAGVVVLKRLTDAQQDGDRVLAVICGSAINQDGRSNGLMAPNPAAQQAVL
TH_2454|M.thermoresistible__bu      GAAVVILKRLPDALRDGDRVIAVIRGGAVAQDGRTVGIMSPNGAAQRDLF
MAB_3148c|M.abscessus_ATCC_199      GCVMVLLKRLDDAVRDGDRILAVVRGTASNQDGRTVNQSTPSSEAQAAAC
MAV_2370|M.avium_104                GSVMLLLKRLNDALRDGDRILAVVRGTAANQDGHTVNIATPSKTAQTAVY
MSMEG_6767|M.smegmatis_MC2_155      GGAVVVIKPLAHALRDGDDIYAQILGTAVSQDGHTDGITVPNEEAQEAAI
                                    *  : ::* * .* :*** : * : * *  ***:: .   *.  **    

Mflv_3395|M.gilvum_PYR-GCK          RSAYAAAGVEPREVDYIEAHGTGTLLGDPIEARALGSVLGRGRAADAPLL
Mvan_3128|M.vanbaalenii_PYR-1       RSAYSAAGVEPRDVDYVETHGTGTLLGDPIEARALGTVLGRGRAADAPLL
Mb2956|M.bovis_AF2122/97            RAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALGTVLGRGRPEDSPLL
Rv2931|M.tuberculosis_H37Rv         RAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALGTVLGRGRPEDSPLL
MLBr_02357|M.leprae_Br4923          RTAYANAAMPPTAIDYVETHGTGTLLGDPIEARALGAVLGRGRAEDSPLL
MMAR_1776|M.marinum_M               RAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALGSVLGRGRPEESPLL
MUL_2019|M.ulcerans_Agy99           RAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALGSVLGRGRPEESPLL
TH_2454|M.thermoresistible__bu      RHTCEITGTSPATVDFVEAHGTGTPTGDPVELDALAAVYGAAHGPDDPCR
MAB_3148c|M.abscessus_ATCC_199      RTALAVAGVEADTVGLIEAHGTGTPVGDPIEYTGLAQVYG----VDGPCA
MAV_2370|M.avium_104                RAALAAAGVDAGTVGMVEAHGPGTPVGDPIEYASLAEVYG----IDGPCA
MSMEG_6767|M.smegmatis_MC2_155      RMALQRAGVEPNDVAYVEAHGTGTPVGDPIEMRALAGALTTDRDATRPLV
                                    * :   :.  .  :  :*:**.**  ***:*  .*. .         *  

Mflv_3395|M.gilvum_PYR-GCK          IGAIKSNLGHTEAAAGIAGFAKTVLALQRGRIPANLDYQSPNPHIPFDNL
Mvan_3128|M.vanbaalenii_PYR-1       LGAVKSNLGHLEAAAGVAGFIKAVLALQHQQIPANLGYEKPNPHIPFDNL
Mb2956|M.bovis_AF2122/97            IGSVKTNLGHTEAAAGIAGFIKTVLAVQHGQIPPNQHFETANPHIPFTDL
Rv2931|M.tuberculosis_H37Rv         IGSVKTNLGHTEAAAGIAGFIKTVLAVQHGQIPPNQHFETANPHIPFTDL
MLBr_02357|M.leprae_Br4923          IGAVKTNLGHLEAAAGIAGFIKTVLAVQRGQIPPNQRFESPNLHIPFAEL
MMAR_1776|M.marinum_M               IGAVKTNLGHTEAAAGIAGFIKAVLAVQHGRIPPNQRFESPNPHIAFADL
MUL_2019|M.ulcerans_Agy99           IGAVKTNLGHTEAAAGIAGFIKAVLAVQHGRIPPNQRFESPNPHIAFADL
TH_2454|M.thermoresistible__bu      VGSVKPNTGHLEGGAGVVGLIKAALALQHGVIPPTAGIRELTPAVDWATN
MAB_3148c|M.abscessus_ATCC_199      VGSVKTNFGHTMSAAGALGLMKIVLAVEHGVVPPNLHFTGIPDKLAPVKT
MAV_2370|M.avium_104                LASVKTNFGHAQAASGALGMMKAILALQHGVVPRNLHFTQLPDDLARIDT
MSMEG_6767|M.smegmatis_MC2_155      IGSVKTNIGHLEAGAGVAGLIKAALIVKHGHIPANLHLKNPTRHVSLTEL
                                    :.::*.* **  ..:*  *: *  * :::  :* .         :     

Mflv_3395|M.gilvum_PYR-GCK          RLKVVDEVTDW-KPVGRPRVAGVSSFGFGGTNAHVVLEQAPDPTPAEDTD
Mvan_3128|M.vanbaalenii_PYR-1       RLKVIAEHTEWPAPAGRPRRAGVSSFGFGGTNAHVVIEQAPPKAPATNGQ
Mb2956|M.bovis_AF2122/97            RMKVVDTQTEW-PATGHPRRAGVSSFGFGGTNAHVVIEQGQEVRPAPGQG
Rv2931|M.tuberculosis_H37Rv         RMKVVDTQTEW-PATGHPRRAGVSSFGFGGTNAHVVIEQGQEVRPAPGQG
MLBr_02357|M.leprae_Br4923          RMKVVDKHMEW-PDTGHLRRAAVSSFGFGGTNAHVVIEQGPELTPVTECS
MMAR_1776|M.marinum_M               RMKVVDELTDW-PDTGHPRRAGVSSFGFGGTNAHVVIEQGQEAASSPEAG
MUL_2019|M.ulcerans_Agy99           RMKVVDELTDW-PDTGHPRRAGVSSFGFGGTNAHVVIEQGQEAASSPEAD
TH_2454|M.thermoresistible__bu      GLHVPTTVEPFPRRADSPRRAAVCSYGYGGTIAHLLLEEAPAVDETPAAA
MAB_3148c|M.abscessus_ATCC_199      NLFVPQTVIPWPGKAQGPRRAGVSAYGMSGSNVHAVVEQAPPVESSTPPA
MAV_2370|M.avium_104                KLFVPQQTTPWVSNGGHPRRAAVSSYGLSGTNVHAILEQAPEPAPETVAP
MSMEG_6767|M.smegmatis_MC2_155      KLDIPTIGRPFPECDR--RIAGINSFGFGGTNAHVVLAEPPAARHSAETG
                                     : :      :       * *.: ::* .*: .* :: :           

Mflv_3395|M.gilvum_PYR-GCK          VAPAA--ASPVTTLVVAGKSAPRIATTAGMLAEWLAG-DGADVPLDQVAH
Mvan_3128|M.vanbaalenii_PYR-1       GEPA------VTTLVVSGRTAERIASEAGMLAEWMAGPEGSLASLPEVAH
Mb2956|M.bovis_AF2122/97            LSPA------VSTLVVAGKTMQRVSATAGMLADWMEG-PGADVALADVAH
Rv2931|M.tuberculosis_H37Rv         LSPA------VSTLVVAGKTMQRVSATAGMLADWMEG-PGADVALADVAH
MLBr_02357|M.leprae_Br4923          SNTA------VSTLVVTGKTASRVAAMAGMLADWVEG-PGAEVALADVAH
MMAR_1776|M.marinum_M               LTPA------LSTLVVAGKTPARVAATAGMLADWMEG-PGAEVALADVAH
MUL_2019|M.ulcerans_Agy99           LTPA------LSTLVVAGKTPARVAATAGMLADWMEG-PGAEVALADVAH
TH_2454|M.thermoresistible__bu      PAPAADAADANSPRFHVIPVSARSGARLARHAAALRGHLSAGADLTAVAA
MAB_3148c|M.abscessus_ATCC_199      VESP---LGSQLIFPVSSTSAEELRRTAARLADWVAE--RPEVAPGDVGY
MAV_2370|M.avium_104                EGIS---AESPLLFPLSSTSADELRRTAGRLADWVHA--HGDLALPDLAY
MSMEG_6767|M.smegmatis_MC2_155      DHRV------LTVLPISARSEEALVATAGRLAGHLAA--HPEVTLADLGY
                                                                .  *  :            :. 

Mflv_3395|M.gilvum_PYR-GCK          SLNHHRAQHSKFATVCTRDRAGALAGLQALAAGHTAPGVVP-PHQGSCRP
Mvan_3128|M.vanbaalenii_PYR-1       TLNHHRSHYNKFATVAARDRDQAIAGLRALAAGQTAPGVVG-APTGARKR
Mb2956|M.bovis_AF2122/97            TLNHHRSRQPKFGTVVARDRTQAIAGLRALAAGQHAPGVVN-PAEGSPGP
Rv2931|M.tuberculosis_H37Rv         TLNHHRSRQPKFGTVVARDRTQAIAGLRALAAGQHAPGVVN-PADGSPGP
MLBr_02357|M.leprae_Br4923          TLNHHRSRHAKFGTVVARDRIQAVAGLRALAAGKQAPGVVG-QQDGTPGS
MMAR_1776|M.marinum_M               TLNHHRSRQARFGTVVARERAQAVAGLRALAANQHAPGVVN-PADAPPEP
MUL_2019|M.ulcerans_Agy99           TLNHHRSRQARFGTVVARERAQAVAGLRALAANQHAPGVVN-PADAPPEP
TH_2454|M.thermoresistible__bu      TMWQRRSHEPVRAAVIARHPGELVAGLDAIATDTRHPAVVAGSVLPAAEA
MAB_3148c|M.abscessus_ATCC_199      TLARRRAHRSVRTAVVADGADELIDALRGVAEGDAP----YPAAVAQDDR
MAV_2370|M.avium_104                TLARRRVHRPVRTAVLAGDRAQLIEALREVADGDTP----YPAAVGRGDR
MSMEG_6767|M.smegmatis_MC2_155      TLSHRRAHLNHRHTFVVDSIDEARRQLQAVADGGQIS------AGRAGEA
                                    :: ::* :     :. .         *  :* .                 

Mflv_3395|M.gilvum_PYR-GCK          GKVFVYSGQGAQWTGMGRRLLADEPAFAAAVAELEPVFVEQVGFSLQQIL
Mvan_3128|M.vanbaalenii_PYR-1       GTVFVYSGQGSQWPGMARQLLADEPAFANALAEIEPVFVEQVGFSLRDVI
Mb2956|M.bovis_AF2122/97            GTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQAGFSLHDVL
Rv2931|M.tuberculosis_H37Rv         GTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQAGFSLHDVL
MLBr_02357|M.leprae_Br4923          GTVFVYSGRGSQWAGMGRQLLADEPAFTAAVAELEPVFVVHAGFSLHDVL
MMAR_1776|M.marinum_M               GTVFVYSGRGSQWAGMGRQLLADEPVFAAAVAELEPVFLAEAGFSLHDVL
MUL_2019|M.ulcerans_Agy99           GTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFLAEAGFSLHDVL
TH_2454|M.thermoresistible__bu      GAVWVFSGHGSHWPGMGRELLEHEPVFAAVIDEIEPVFRAELGFSPRQAL
MAB_3148c|M.abscessus_ATCC_199      GPVWLFSGQGSQWAGMGAELLGKEPVFAETIARLEPLIHAESGFSVTDAI
MAV_2370|M.avium_104                GPVWVFSGQGSQWAAMGADLLATEPVFAATVAQAEPLIARESGFSVAEAM
MSMEG_6767|M.smegmatis_MC2_155      RLAFVCTGMGPQWWQMCRGLLDVFPVFTDSIHRTDRELSRYADWSLLEEL
                                      .:: :* *.:*  *   **   *.*:  : . :  :    .:*  : :

Mflv_3395|M.gilvum_PYR-GCK          A---GGETVTGIDRIQPVLVGMQLALTELWRAYGVHPDAVIGHSMGEVAA
Mvan_3128|M.vanbaalenii_PYR-1       A---GGETVSGDAQVQPVLMGLQLALTELWRSYDVHPDAVIGHSMGEVTA
Mb2956|M.bovis_AF2122/97            A---NGEELVGIEQIQLGLIGMQLALTELWCSYGVQPDLVIGHSMGEVAA
Rv2931|M.tuberculosis_H37Rv         A---NGEELVGIEQIQLGLIGMQLALTELWCSYGVRPDLVIGHSMGEVAA
MLBr_02357|M.leprae_Br4923          A---NGKELVGIEQIQLGLIGMQLTLTELWRSYGVQPDLVIGHSLGEVAA
MMAR_1776|M.marinum_M               A---NGTELVGIEQIQLGLIGMQLTLTELWRSYGIQPDLVIGHSMGEVAA
MUL_2019|M.ulcerans_Agy99           A---NGTELVGIEQIQLGLIGMQLTLTELWRSYGIQPDLVIGHSMGEVAA
TH_2454|M.thermoresistible__bu      Q---SGE-LGGTDRVQALTFAVQAGLAAVLRDRGVKPAAVIGHSVGEVAA
MAB_3148c|M.abscessus_ATCC_199      S---APETVTGIDRVQPTLFAMQVSLAATLASYGVRPGAVIGHSMGEVAA
MAV_2370|M.avium_104                S---APQTVTGQDRVQPTLFTMQVALAATMKAHGVRPGAVIGHSLGEAAA
MSMEG_6767|M.smegmatis_MC2_155      TRDEASSRMGETEFAQPANFAIQVALAEQLAHFGITPDAVIGHSAGEVAA
                                            :      *   . :*  *:      .: *  ***** **.:*

Mflv_3395|M.gilvum_PYR-GCK          SVVAGALSVADGLKVIATRSKLMSRLSGQGAMALIELDPDAATALIAD--
Mvan_3128|M.vanbaalenii_PYR-1       AVVAGALSLADGLKVIAARSSIMSRLAGQGAVALVELDPEAAAAFIAD--
Mb2956|M.bovis_AF2122/97            AVVAGALTPAEGLRVTATRSRLMAPLSGQGGMALLELDAPTTEALIAD--
Rv2931|M.tuberculosis_H37Rv         AVVAGALTPAEGLRVTATRSRLMAPLSGQGGMALLELDAPTTEALIAD--
MLBr_02357|M.leprae_Br4923          AVVAGALTAAEGLRVTATRSRLMAPLSGQGGMALLELDAVETEALIVD--
MMAR_1776|M.marinum_M               AVVAGALTPAEGLRVTAVRSRLMAPLSGQGGMALLELDASQTEALIAD--
MUL_2019|M.ulcerans_Agy99           AVVAGALTPAEGLRVTAVRSRLMAPLSGQGGMALLGLDASQTEALIAD--
TH_2454|M.thermoresistible__bu      CVAAGVFDLARGAAVACYRARGFRSVAGKGAMALVGLPFEDARQRLGE--
MAB_3148c|M.abscessus_ATCC_199      AVVSEALSLEDGVKVICRRSQLMLRISGAGAMASVDLPAQQVVSELADRD
MAV_2370|M.avium_104                AVVAGALSLEDGARVICRRSRLMSRVAGTGATASVELPAQQVLSELTARG
MSMEG_6767|M.smegmatis_MC2_155      HHIAGLLTFEQAVHVIYHRSRLQQRTTGQGRMLAVGLDAETLMQILDEKI
                                       :  :    .  *   *:      :* *    : *        :    

Mflv_3395|M.gilvum_PYR-GCK          ----YPDVTLAVYASPRQTVIAGPPDQVDAVIAAVSAQDRLARRIEVDVA
Mvan_3128|M.vanbaalenii_PYR-1       ----YPSVEVAGFVSPRQTVVAGLPEQVDAVIAAVTAQEKFARRVNMEVA
Mb2956|M.bovis_AF2122/97            ----FPQVTLGIYNSPRQTVIAGPTEQIDELITRVRARDRFASRVNIEVA
Rv2931|M.tuberculosis_H37Rv         ----FPQVTLGIYNSPRQTVIAGPTEQIDELIARVRAQNRFASRVNIEVA
MLBr_02357|M.leprae_Br4923          ----YSQVTLAIYNSPRQTVIAGPTEQIDELIDRVRAQNRFASRVNIEVA
MMAR_1776|M.marinum_M               ----YPQVTLGIYNSPRQTVISGPTDQIDELITVVRARDRFATRVNIEVA
MUL_2019|M.ulcerans_Agy99           ----YPQVTLGIYNSPRQTVISGPTDQIDELITVVRARDRFATRVNIEVA
TH_2454|M.thermoresistible__bu      ----RTDVVAAISASPLSTVISGTVDAVGEVSAAWAEQGVMVRKVNTDVA
MAB_3148c|M.abscessus_ATCC_199      ----IHDVVLAVVASPQSTVVGGATETVRQLIAEWSDRGLMAREVAVDVA
MAV_2370|M.avium_104                ----ISDVVVAVVASPQSTVIAGAAPTVRDLVTAWQERGVMAREVPTDVA
MSMEG_6767|M.smegmatis_MC2_155      LDQFGRRVSVAAINSPSAVTVAGDADVLEDIARHLDEAQIFNRYLAVKVP
                                           *  .   **  ..:.*    :  :         :   :  .*.

Mflv_3395|M.gilvum_PYR-GCK          SHHPTIDPILPELREALSGLRPVSPNIPIVITTREHDGPE----PVFDAD
Mvan_3128|M.vanbaalenii_PYR-1       SHTALMDPVLPDLREALAGVTPRTPNIPFLSTVTEPDG-E----PALDAD
Mb2956|M.bovis_AF2122/97            PHNPAMDALQPAMRSELADLTPRTPTIGIISTTYADLHTQ----PVFDAE
Rv2931|M.tuberculosis_H37Rv         PHNPAMDALQPAMRSELADLTPRTPTIGIISTTYADLHTQ----PVFDAE
MLBr_02357|M.leprae_Br4923          PHNPAMDALQPQMRSELADVAPRTPTIPILSTTYADLGSC----PVFDAQ
MMAR_1776|M.marinum_M               PHNPAMDALQPQMRSELADLAPRTPTIPIISTTYADLGSARESGPTFDAE
MUL_2019|M.ulcerans_Agy99           PHNPAMDALQPQMRSELADLAPRTPTIPIISTTYADLGAARESGPTFDAE
TH_2454|M.thermoresistible__bu      FHSPAMDALTAELARLTSTLTPKPAAVPLYSTALADPRST----AARDEH
MAB_3148c|M.abscessus_ATCC_199      SHSPQVDPILDDLADALEDLTPRTPVVPLYSSVSFDPRER----PIMDAD
MAV_2370|M.avium_104                FHSPQVDPIMDDLTDALAEISPRPPEVPYYSATLFDPREQ----PVCDAR
MSMEG_6767|M.smegmatis_MC2_155      YHTHYMETIKDDLHTAFASLSSKAATLPLYSTVTGELLDR----YDAGAA
                                     *   ::.:   :      : . .. :    :.              .  

Mflv_3395|M.gilvum_PYR-GCK          YWVDNLRNPVRFEQAVAAAGA----EIGTFIEVSPHPLLTYGISDTLG--
Mvan_3128|M.vanbaalenii_PYR-1       YWVANVRQPVKFSQAVTAAAQ----EIGTFIEVSANPILTYAINDTLS--
Mb2956|M.bovis_AF2122/97            HWATNMRNPVHFQQAIASAGSGADGAYHTFIEISAHPLLTQAIIDTLHSA
Rv2931|M.tuberculosis_H37Rv         HWATNMRNPVRFQQAIASAGSGADGAYHTFIEISAHPLLTQAIIDTLHSA
MLBr_02357|M.leprae_Br4923          HWATNMRNPVHFQQAIMTAGT----DHRTFIEISAHPLLTQAITDTLH--
MMAR_1776|M.marinum_M               HWAINMRNPVHFQQAITAAAT----DKHNFIEISAHPLLTQAILETLHTV
MUL_2019|M.ulcerans_Agy99           HWAINMRNPVHFQQAITAAAT----DKHNFIEISAHPLLTQAILETLHTV
TH_2454|M.thermoresistible__bu      YWVANLRGRVRFAEAVTAAAEDG---HRLFLEVSAHPVVCHSMAETLALA
MAB_3148c|M.abscessus_ATCC_199      YWVDNLRHTVRFAAAVQAALDDG---YRVFGELAPHPLLVYPAEQTARSL
MAV_2370|M.avium_104                YWANNMRRMVRFATAVQAALEDG---YRVFAELAPHPLLVRALEQTARSR
MSMEG_6767|M.smegmatis_MC2_155      YWWQNTRATVLFEPAMRRMLDDG---YTHFVELGPHPVLAASILESAGTQ
                                    :*  * *  * *  *:             * *:..:*::     ::    

Mflv_3395|M.gilvum_PYR-GCK          --TSHHHSVPTLLRETGSEGDEASDETLSFHTNLNSTFTTKPPVSDHGPE
Mvan_3128|M.vanbaalenii_PYR-1       --SASHVSLGTLARD--------ADDTLTFHTALNATFTGHPPVTPHHGE
Mb2956|M.bovis_AF2122/97            QPGARYTSLGTLQRD--------TDDVVTFRTNLNKAHTIHPPHTPHPPE
Rv2931|M.tuberculosis_H37Rv         QPGARYTSLGTLQRD--------TDDVVTFRTNLNKAHTIHPPHTPHPPE
MLBr_02357|M.leprae_Br4923          --GTRCISIGTLQRD--------ADDTVTFHTNLNNVHTVHPPHTPHPAE
MMAR_1776|M.marinum_M               QPGSKYTSLGTLQRD--------SDDTIVFRTNLNTVRTA-PPQTPHPPE
MUL_2019|M.ulcerans_Agy99           QPGSKYTSLGTLQRD--------SDDTIVFRTNLDTVRTA-PPQTPHPPE
TH_2454|M.thermoresistible__bu      EVGEHAVLPVLRREQP------ELPAVAAVVGALYCHGAPVRPAFPPGTR
MAB_3148c|M.abscessus_ATCC_199      DIPMVALAGMRREQE-------LPHGLRDFVGDLYTAGGAVDFSVLYPTG
MAV_2370|M.avium_104                EIPMAALAGMRRGQA-------LPHGLRGFVADLHNAGAAVDFSVLYPTG
MSMEG_6767|M.smegmatis_MC2_155      RVSVDASQRRGQDDAR---------TLLNCVGALHSRGHEVAWDMVQPRA
                                                                     *                

Mflv_3395|M.gilvum_PYR-GCK          --PHPVLPATPWHHTRHWVAHKKVDRRGPSAPRPGTLLGDLT---SVATS
Mvan_3128|M.vanbaalenii_PYR-1       --PHIQLPTTPWHHTHHWAIRKHTAS-GATAPRPGTVLGSHT---AVAGT
Mb2956|M.bovis_AF2122/97            --PHPPIPTTPWQHTRHWITTKYPAGSVGSAPRAGTLLGQHTTVATVSAS
Rv2931|M.tuberculosis_H37Rv         --PHPPIPTTPWQHTRHWITTKYPAGSVGSAPRAGTLLGQHTTVATVSAS
MLBr_02357|M.leprae_Br4923          --PHVTIPSTPWQHTRHWIPRKRSVNSIGLAPQVGTLLGQHT---AVSGI
MMAR_1776|M.marinum_M               --PHPQIPTTPWHHTHHWIDTPAVASRSASTPDKD----------AAGSS
MUL_2019|M.ulcerans_Agy99           --PHPQIPTTPWHHTHHWIDTPAVASRSASTPDKD----------AAGSS
TH_2454|M.thermoresistible__bu      --WATGLPGTQWQHRRFWRTPGTPPGGVGVHDVDSHTLLGGR--IDVAGA
MAB_3148c|M.abscessus_ATCC_199      --QLVDVPLPSWTRRSYLLDLSAQAQQGHGTHTVAVHPLLGA-HVRLAEE
MAV_2370|M.avium_104                --RLVDAPLPTWTHRRLWLTDGGLESPTHGGCTVAVHPLLGP-HVHLQEE
MSMEG_6767|M.smegmatis_MC2_155      GAHPVKLPSYPWQTKRFWNDTHEAEEALFYRPVHPLLGQPVR--------
                                           *   *                                      

Mflv_3395|M.gilvum_PYR-GCK          PPTHLWQARLVRDAKPYPGFHRIQGVEVVPMSVLLRTLAAAAAESG--AS
Mvan_3128|M.vanbaalenii_PYR-1       QPGHLWQARLAPQAKPYPQPHKFAGVEIVPLSVLLQTLSLAAAESG--AR
Mb2956|M.bovis_AF2122/97            PPSHLWQARLAPDAKPYQGGHRFHQVEVVPASVVLHTILSAATELG--YS
Rv2931|M.tuberculosis_H37Rv         PPSHLWQARLAPDAKPYQGGHRFHQVEVVPASVVLHTILSAATELG--YS
MLBr_02357|M.leprae_Br4923          LPIHLWQARLAPQAKPYRGWHRVHGVEVVPASIVLRTILCAAAELG--YS
MMAR_1776|M.marinum_M               EPSVSGDSDDAVDSCHYR--------------------------------
MUL_2019|M.ulcerans_Agy99           EPSVSGDSDDAVDSCHYR--------------------------------
TH_2454|M.thermoresistible__bu      VPARVWQTRLDLSTRPYPGDHPVQGTEIVPAAVLLNTFLTAAG------S
MAB_3148c|M.abscessus_ATCC_199      PERHIWQADVGTVGQPWIADHQVRHVAVYPGAAYCEMALSAAAAVFGEGS
MAV_2370|M.avium_104                PERHLWQADVGTAAQPWLADHQIRNVVVLPGAAYCEMALAAARSVLGATA
MSMEG_6767|M.smegmatis_MC2_155      AVHPTWEAEFSTLTVPFLADHQVQGSVVVPGAVYVEMALAAGRETYGSDL
                                          ::        :                                 

Mflv_3395|M.gilvum_PYR-GCK          ALADIRFDRPVVVDQPQVIQVVAHGDTITMAS---APHADAPANR-----
Mvan_3128|M.vanbaalenii_PYR-1       AVADVRFDFPITVDAPRVVQVVSDGETITVSSSTAAAGSDDSAQR-----
Mb2956|M.bovis_AF2122/97            ALSEVRFEQPIFADRPRLIQVVADNRAISLAS---SPAAGTPSDR-----
Rv2931|M.tuberculosis_H37Rv         ALSEVRFEQPIFADRPRLIQVVADNRAISLAS---SPAAGTPSDR-----
MLBr_02357|M.leprae_Br4923          TLFEIRFEQPIFANLPRLIQVVVDNQLISLAS---SPATETPQHR-----
MMAR_1776|M.marinum_M               --------------------VGWPTKPLADAK---ASTETASGTR-----
MUL_2019|M.ulcerans_Agy99           --------------------VGWPTKPLADAK---ASTETASGTR-----
TH_2454|M.thermoresistible__bu      DIADVRLRTPVAPARTRDVQVVLQDRALALASRIVGEDTTARATAGRDTT
MAB_3148c|M.abscessus_ATCC_199      AVQSISFEQLLTLGESTPISATATAKSADILEFVVETHDEGDVVKRAT--
MAV_2370|M.avium_104                EVRDIRFEQALLLDEQTTVDASASVSSPGVLHFTVQSHQGGEQARHAS--
MSMEG_6767|M.smegmatis_MC2_155      SVDNLVLHRAVILDDTCDPVIRTTVDQDDGSVEFAALIATADTDLK----
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          ----------------------WVRHATARVA-QPRPADTGAVDVTAATD
Mvan_3128|M.vanbaalenii_PYR-1       ----------------------WIRHLTARVA-HRVADSPATAGTAQSSG
Mb2956|M.bovis_AF2122/97            ----------------------WTRHVTAQLS-SSPSDSASSLNEHHRAN
Rv2931|M.tuberculosis_H37Rv         ----------------------WTRHVTAQLS-SSPSDSASSLNEHHRAN
MLBr_02357|M.leprae_Br4923          ----------------------WTRHVTAQLS-SASARSAVPSDHPDQIN
MMAR_1776|M.marinum_M               ----------------------WLVFADAELG-AELGLAAG---------
MUL_2019|M.ulcerans_Agy99           ----------------------WLVFADAELG-AELGLAAG---------
TH_2454|M.thermoresistible__bu      DRDTTACDTTDRDTTACDDPGVWLTHCTARVA-DDHVGAEGVLDEEAIRA
MAB_3148c|M.abscessus_ATCC_199      ----------------------AVLGNGGDVD-MPIAYDLSALRAEHPHR
MAV_2370|M.avium_104                ----------------------AVLG-AATDE-QPAAHDLSALLTAHPHD
MSMEG_6767|M.smegmatis_MC2_155      ----------------------WVITATAELNTLPRAPRAGDTGGGAVTS
                                                                .                     

Mflv_3395|M.gilvum_PYR-GCK          ---------YDRSTVEELQSRWGVEGQPFPWSIET-------CRATSDGV
Mvan_3128|M.vanbaalenii_PYR-1       ---------YDPSALAELHNAWGIDGMAYPWTVAS-------HESAPGEL
Mb2956|M.bovis_AF2122/97            GQPPERAHRDLIPDLAELLAMRGIDGLPFSWTVASWT---QHSSNLTVAI
Rv2931|M.tuberculosis_H37Rv         GQPPERAHRDLIPDLAELLAMRGIDGLPFSWTVASWT---QHSSNLTVAI
MLBr_02357|M.leprae_Br4923          G--HLEVISDPIPDVASLLALCGVDGLPFEWSVKSWAKKTQQSTSRTVEI
MMAR_1776|M.marinum_M               -------------------------------------------AQTRVDV
MUL_2019|M.ulcerans_Agy99           -------------------------------------------AQTRVDV
TH_2454|M.thermoresistible__bu      R----CPQPLPAGHVVDTLAGLGVAAMGFGWEVLELHR--GEGELFARVA
MAB_3148c|M.abscessus_ATCC_199      ESGDDLRASFDERGVQYGPAFQGLAAAYRGDETVRSVLAEVTLPRDVRAQ
MAV_2370|M.avium_104                DDGDEVRRRMDRRGVQYGPAFAGLGAVHSGDETG-TVLAEVALPRQIRSQ
MSMEG_6767|M.smegmatis_MC2_155      TDGDTFYQRTQALGFDYGEAFRSVASVTAGRDWAVAQID---IPQSISAD
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          LAEVRWQDGSAVALLDAAVQVARLADINDDRLLVPAAVESLTATGELLAS
Mvan_3128|M.vanbaalenii_PYR-1       RTVIDLTPGSLVGLLDAAVNLGRLVDSSSPGLMVPSAAESVRFGDDATGT
Mb2956|M.bovis_AF2122/97            DLPEALPEGSTGPLLDAAVHLAALSDVADSRLYVPASIEQISLGDVVTGP
Rv2931|M.tuberculosis_H37Rv         DLPEALPEGSTGPLLDAAVHLAALSDVADSRLYVPASIEQISLGDVVTGP
MLBr_02357|M.leprae_Br4923          EFPDTLPDGAIAPLLDAAILIPALADVTETQFYVPASIKQVWLGDTATGP
MMAR_1776|M.marinum_M               IDPSALTEESE--------LLAALAGVEH---------------------
MUL_2019|M.ulcerans_Agy99           IDPSALTEGSE--------LLAALAGVEH---------------------
TH_2454|M.thermoresistible__bu      AEPDKSAPATWAGLIDAATSTASTIFDGPPRLRMPARIERVHVRDKPP--
MAB_3148c|M.abscessus_ATCC_199      QGSYIVHPALLDACFQSVIALPDVQEASKDALPLPKGVRSLHAYESAR-A
MAV_2370|M.avium_104                QAAYGAHPALLDACFQSVEAHPAVRALGDGALGLVLGIRRLRAYGAAR-N
MSMEG_6767|M.smegmatis_MC2_155      VDTYRFHPALIDGAFQTLFGAPFSGQEENTDPYLPTRIRHCAVYG-PPAE
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          SGTVTVRRRPGTGEDLVLDVAVTVPDDSTRVDIVGLRYVDVQAG------
Mvan_3128|M.vanbaalenii_PYR-1       GGVITARSRGRDGDDLLVDISIGGAGGAEYAHITGLRYTPVEIGT-----
Mb2956|M.bovis_AF2122/97            RSSVTLNRTAHDDDGITVDVTVAAHGEVPSLSMRSLRYRALDFGLDVGRA
Rv2931|M.tuberculosis_H37Rv         RSSVTLNRTAHDDDGITVDVTVAAHGEVPSLSMRSLRYRALDFGLDVGRA
MLBr_02357|M.leprae_Br4923          CGAVTLNRTACDDDGITVDVTVADGSGVPLALMRSLRYRALDLDNAQQDY
MMAR_1776|M.marinum_M               --------------------------------------------------
MUL_2019|M.ulcerans_Agy99           --------------------------------------------------
TH_2454|M.thermoresistible__bu      --AIALLHVRRRPEGTVTDVTIAEESGAVSVTLTGMGFEELENPG-----
MAB_3148c|M.abscessus_ATCC_199      TQYCYTRVTKVVGNEVEADIDLLDETGSVLIAVRGFRFGTGSSDDEQRDQ
MAV_2370|M.avium_104                AHYCYTRVTKADTSGVEADIDVLDEHGAVLLAVQGLRVGTSASESGTRDR
MSMEG_6767|M.smegmatis_MC2_155      HMTVRARVLSATHDAVECDITITDPSGGVLAAFDGFTVQSLSASS-----
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          ------PAEAAPADPRSVAHEIAWRPWTAPSETAPAGASLAVVGS-----
Mvan_3128|M.vanbaalenii_PYR-1       ------VTTSAAADPQRVAHRLDWQPWTPAADAGPDTGSVAVIGD-----
Mb2956|M.bovis_AF2122/97            QPPASTGPVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAIIG
Rv2931|M.tuberculosis_H37Rv         QPPASTGPVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAIIG
MLBr_02357|M.leprae_Br4923          STVFVESHVDALTDARNFVHAIDWQPRTDLDCSN---TPVASSGSVAVIG
MMAR_1776|M.marinum_M               --------------------------------------------------
MUL_2019|M.ulcerans_Agy99           --------------------------------------------------
TH_2454|M.thermoresistible__bu      -------GGGSSGDLTGMLHHLRWHPVDWPDTDPPAAVVLVG--------
MAB_3148c|M.abscessus_ATCC_199      LLNNRLLAIEWQQQRLPESVSGAPRRWLLVSTGESVDPWAAELIDSLKVR
MAV_2370|M.avium_104                VLTERLLNIEWRQRELPEPEHADAASWLLIGTTATADVLASTLADTLKNH
MSMEG_6767|M.smegmatis_MC2_155      ----RMSADHIDKGLFALEWSPVTDTPDTAHGDESTWLILTDNGGVGEAI
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          ---GTTADALRERLAAAGYTDADEATAQCVLYVP-----GPDGDDLDATV
Mvan_3128|M.vanbaalenii_PYR-1       ---DDVAAAVRGAVAANGHAVAEIPDARFVVYVAD---VGDVDSDQDVAV
Mb2956|M.bovis_AF2122/97            DDGAALCETLEGAGYQPAVMSDGVSQARYVVYVADSDPAGADETDVDFAV
Rv2931|M.tuberculosis_H37Rv         DDGAALCETLEGAGYQPAVMSDGVSQARYVVYVADSDPAGADETDVDFAV
MLBr_02357|M.leprae_Br4923          DARAGFGLLLKEAGYTLAAPADGVSEVRYVVYVADPHPATTAETDVDFAV
MMAR_1776|M.marinum_M               -----------------------------VVYAP---PAG-KSLDVNAAY
MUL_2019|M.ulcerans_Agy99           -----------------------------VVYAP---PAG-KSLDVNAAY
TH_2454|M.thermoresistible__bu      ---GDARTRAFVTRDLDEARVAHRSYADPAALPPDLTAGTVVLVLPRTAA
MAB_3148c|M.abscessus_ATCC_199      ESEVSLIQWRPNTDRVAALKLLYDQLESGTFDGVLVVTAPGSEGGADRVV
MAV_2370|M.avium_104                GAQCTTMAWPQQADHTAHAEQLRNQWRGDGFTGVVVLTGPKNGDNDQESA
MSMEG_6767|M.smegmatis_MC2_155      ADGLRLRGHHVHTVAHDPTGEIDWPDMLATHLSGERTGLIDCWPLEVTDA
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          RLCGEVASLVSRLADRPGTGEPR---LWILTEGVRDADSA-------QSL
Mvan_3128|M.vanbaalenii_PYR-1       RLTTEVADLVGTLAERDPRNPAT---LWIVTRGVYESATA-------AAL
Mb2956|M.bovis_AF2122/97            RICTEITGLVRTLAERDADKPAA---LWILTRGVHESVAP-------SAL
Rv2931|M.tuberculosis_H37Rv         RICTEITGLVRTLAERDADKPAA---LWILTRGVHESVAP-------SAL
MLBr_02357|M.leprae_Br4923          RITAEISDLVRALAKREPGKPVA---LWIVTRGVYESVAS-------SAL
MMAR_1776|M.marinum_M               QLFHQVRRLVTVMTK--ASLTAK---LLLVTRNAQPIAEGDR-----ANP
MUL_2019|M.ulcerans_Agy99           QLFHQVRRLVAVMTK--ASLTAK---LLLVTRNAQPIAEGDR-----ANP
TH_2454|M.thermoresistible__bu      RPAASAQLVLHTLQRLSATNSGAR--LWVLTRGVHEGTDP----------
MAB_3148c|M.abscessus_ATCC_199      LQGADQVRHLVRITRELVDLPGEPPRLFVVTRNAQTVVDGDI-----TNL
MAV_2370|M.avium_104                LLSRDHVQHLVRIARELTDLPGEPPRLYVVTRNAQTVLPNDV-----PNL
MSMEG_6767|M.smegmatis_MC2_155      ATDPAGTATVLRIVKALATLDGVTPRLYLVTANAQPAAGTELTGTELTGV
                                             :  :             * ::* ..                

Mflv_3395|M.gilvum_PYR-GCK          PHSSLWGLAGVVGAEQP-QLWGGLVDVASG--------------------
Mvan_3128|M.vanbaalenii_PYR-1       PQSTLWGLAGVVGAEQP-QLWGGLVDLAG---------------------
Mb2956|M.bovis_AF2122/97            RQSFLWGLAGVIAAEHP-ELWGGLVDLAIN--------------------
Rv2931|M.tuberculosis_H37Rv         RQSFLWGLAGVIAAEHP-ELWGGLVDLAIN--------------------
MLBr_02357|M.leprae_Br4923          RQSFLWGFGGVIAAEHP-EMWGGLVDLAASALGA----------------
MMAR_1776|M.marinum_M               AHGVLWGLGRTIALEHP-EIWRGIIDLDES--------------------
MUL_2019|M.ulcerans_Agy99           AHGVLWGLGRTIALEHP-EIWRGIIDLDES--------------------
TH_2454|M.thermoresistible__bu      GHGPLWGLARVAAAEHP-QLWGGLLDIGED--------------------
MAB_3148c|M.abscessus_ATCC_199      EQAGLRGLVRVIGAEYP-HLRVTHIDVDRHTAAQNVAGELVSGSEEDETA
MAV_2370|M.avium_104                GQAGLRGLVRVIGMEHP-QLGAGQIDVDESTDAQALARQLLAGSEEDETA
MSMEG_6767|M.smegmatis_MC2_155      EQAAFWGLGRVIGHQELGEYWGGLIDIDHAD-------------------
                                     :. : *:  . . :   .     :*:                       

Mflv_3395|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3128|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb2956|M.bovis_AF2122/97            --------------------------------------------------
Rv2931|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_02357|M.leprae_Br4923          --------------------------------------------------
MMAR_1776|M.marinum_M               --------------------------------------------------
MUL_2019|M.ulcerans_Agy99           --------------------------------------------------
TH_2454|M.thermoresistible__bu      --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199      WREDHWYRARLNLGPLGPDDWRSTVATPNNEGVRFEVRTPGDLQSLGFVA
MAV_2370|M.avium_104                WRDGAWYTARLCPAPLLPEERHTAVANHECDGMRLQIRTPGDLESLELVA
MSMEG_6767|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3128|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb2956|M.bovis_AF2122/97            --------------------------------------------------
Rv2931|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_02357|M.leprae_Br4923          --------------------------------------------------
MMAR_1776|M.marinum_M               --------------------------------------------------
MUL_2019|M.ulcerans_Agy99           --------------------------------------------------
TH_2454|M.thermoresistible__bu      --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199      FDRVAPGPGQIEVSVTATSINFADVLNVYGRYSSFEGRQ-ELGVDFAGVV
MAV_2370|M.avium_104                CDRIPPGPGQIEVAVSASSINFADVLVAFGRYPAFEGRLPELGTDFAGVV
MSMEG_6767|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3128|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb2956|M.bovis_AF2122/97            --------------------------------------------------
Rv2931|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_02357|M.leprae_Br4923          -------------------------------------------------D
MMAR_1776|M.marinum_M               --------------------------------------------------
MUL_2019|M.ulcerans_Agy99           --------------------------------------------------
TH_2454|M.thermoresistible__bu      --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199      TAVGEGVTQHQVGDRVGGMTPTGAWRSFVVVDANLAATLPAEVPDREAAA
MAV_2370|M.avium_104                TAVGPDVTDHKVGDHVGGLSANGCWGTFLTCDARLAVTLPPGLADDQAAA
MSMEG_6767|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          --ADLDETAKALAGVLPVAAKSILSLRGGEFFAPELAALASDP-------
Mvan_3128|M.vanbaalenii_PYR-1       --EDPAGSAEALAALLPTPVKSVAILRDGQLRTSVLAEFTEAP-------
Mb2956|M.bovis_AF2122/97            --DDLGEFGPALAELLAKPSKSILVRRDGVVLAPALAPVRGEP-------
Rv2931|M.tuberculosis_H37Rv         --DDLGEFGPALAELLAKPSKSILVRRDGVVLAPALAPVRGEP-------
MLBr_02357|M.leprae_Br4923          RDDILDQFGPTLASLLQTPTRSIVVLRDGVVLAPTLVPIRSEP-------
MMAR_1776|M.marinum_M               -MPAELAAPKILGEVTGTDGEDQVVYRCGGRHVPRLQ-RRTAP-------
MUL_2019|M.ulcerans_Agy99           -MPAELAAPKILGEVTGTDGEDQVVYRCGSRHVPRLQ-RRTAP-------
TH_2454|M.thermoresistible__bu      --------RLPVRALTALTGHGVVVVRDGVAHTARLAPAGPGAR------
MAB_3148c|M.abscessus_ATCC_199      VPGAHVTAWYGLHELARISAGDKVLIHSGTGGVGQAAIAIARAAGAEIYA
MAV_2370|M.avium_104                VTTAHATAYYGLHELARIGAGDRVLIHSATGGVGQAAIAIARAAGAEIFA
MSMEG_6767|M.smegmatis_MC2_155      --APSSTAEQICGHVLGDGAEDQIALRGNQILAPRLRPCSGLT-------
                                                  :      .    :     .         .       

Mflv_3395|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3128|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb2956|M.bovis_AF2122/97            --------------------------------------------------
Rv2931|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_02357|M.leprae_Br4923          --------------------------------------------------
MMAR_1776|M.marinum_M               --------------------------------------------------
MUL_2019|M.ulcerans_Agy99           --------------------------------------------------
TH_2454|M.thermoresistible__bu      --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199      TAGSPERRDLLRSWGIKHVYDSRSTDFAELIRRDTDGYGVDIVLNSLTGA
MAV_2370|M.avium_104                TAGSEQRRQLLRDMGIEHVYDSRTVEFADLIRHDTDGYGVDIVLNSVTGA
MSMEG_6767|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3128|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb2956|M.bovis_AF2122/97            --------------------------------------------------
Rv2931|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_02357|M.leprae_Br4923          --------------------------------------------------
MMAR_1776|M.marinum_M               --------------------------------------------------
MUL_2019|M.ulcerans_Agy99           --------------------------------------------------
TH_2454|M.thermoresistible__bu      --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199      AQRAGVELLTFGGRFIEIGKRDIYGDTRLGLFPFRRNLSFHAVDLVLVAK
MAV_2370|M.avium_104                AQRAGIELLAFGGRFVEIGKRDIYGDTRLGLLPFRRNLTFYALDLALMSF
MSMEG_6767|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3128|M.vanbaalenii_PYR-1       --------------------------------------------------
Mb2956|M.bovis_AF2122/97            --------------------------------------------------
Rv2931|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_02357|M.leprae_Br4923          --------------------------------------------------
MMAR_1776|M.marinum_M               --------------------------------------------------
MUL_2019|M.ulcerans_Agy99           --------------------------------------------------
TH_2454|M.thermoresistible__bu      --------------------------------------------------
MAB_3148c|M.abscessus_ATCC_199      TRPEAIYRTLTALYGQMAEGVLPLPEISPSPLQEAAESIRVMGAAGHTGK
MAV_2370|M.avium_104                SHPDRLRGLLRTVYRLTADGALPMPESTHYPLADAASAIRVMSAAQHTGK
MSMEG_6767|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mflv_3395|M.gilvum_PYR-GCK          ----------------VREPLRCRPDAAYLITGGLGALGLVTAEWLADRG
Mvan_3128|M.vanbaalenii_PYR-1       ----------------ARETLRCRPDAAYLITGGMGVLGLLMADWLADRG
Mb2956|M.bovis_AF2122/97            ----------------ARKSLQCRPDAAYLITGGLGALGLLMADWLADRG
Rv2931|M.tuberculosis_H37Rv         ----------------ARKSLQCRPDAAYLITGGLGALGLLMADWLADRG
MLBr_02357|M.leprae_Br4923          ----------------VRKSLQCKSDGAYLITGGMGALGLLMADWLADRG
MMAR_1776|M.marinum_M               ----------------AVAPVTLDPNSSQLVIGATGNIGPYLIRQLAQMG
MUL_2019|M.ulcerans_Agy99           ----------------AVAPVTLDPNSSQLVIGATGNIGPYLIRQLAQMG
TH_2454|M.thermoresistible__bu      --------------DSAGEGLRCSPGGTYLITGGTGALGLRLAHRLADLG
MAB_3148c|M.abscessus_ATCC_199      LVLDLPKAGEVSAVIPPSHAPAFRRDGAYVVTGGLGGLGLFLARKLAAAG
MAV_2370|M.avium_104                LVLDVPHAGRSRVVVPPAQVRAFRSDGAYIVTGGLGGLGLFLAEKMASPG
MSMEG_6767|M.smegmatis_MC2_155      ----------------KPFPTKLTADATYVVTGGAGALGRVVATYLAERG
                                                             ..: :: *. * :*      :*  *

Mflv_3395|M.gilvum_PYR-GCK          ----ARRVVLAGRTALPPRRRWDDDDLDKDARDKIAAVRALELRGVAVEL
Mvan_3128|M.vanbaalenii_PYR-1       ----ARRVVLAGRTPLPPRRDWDDESIDADTRHKIAAIRALELRGVSVDT
Mb2956|M.bovis_AF2122/97            ----AHRLVLTGRTPLPPRRDWQLDTLDTELRRRIDAIRALEMRGVTVEA
Rv2931|M.tuberculosis_H37Rv         ----AHRLVLTGRTPLPPRRDWQLDTLDTELRRRIDAIRALEMRGVTVEA
MLBr_02357|M.leprae_Br4923          ----ARRLVLMGRTPLPPRRDWELDTLDAGLRQKIDAICALEMRGVTVEA
MMAR_1776|M.marinum_M               ----AKTVVAVSRNPG---------------QRLQELAESLAAEGTNLVI
MUL_2019|M.ulcerans_Agy99           ----AKTVVAVSRNPG---------------QRLQELAESLAAEGTNLVI
TH_2454|M.thermoresistible__bu      ----ARRLVLVSRSGMPARDSWG----RAGDSDTVAAITALEERGVSVRV
MAB_3148c|M.abscessus_ATCC_199      ----VGRIILNGRSAPKP--------------EALAAIEQIRQGGTEIDV
MAV_2370|M.avium_104                SRAGCGRIVLCSRALPNP--------------KALATLERIRQMGADIVV
MSMEG_6767|M.smegmatis_MC2_155      ----ARHITLLGRSPISPRDRWASITEDDAHHATVDAIRAIERLGAHVST
                                           :   .*                           :   *. :  

Mflv_3395|M.gilvum_PYR-GCK          APVDIGSRDAVEALLTRRDEQGAPPIRGVIHGAGLTDSQLLTDIDDERLR
Mvan_3128|M.vanbaalenii_PYR-1       VALDVGSREALTAVLDKRDGDGAPPIRGVIHAAGMTEAQLLTEIEADRVH
Mb2956|M.bovis_AF2122/97            VAADVGCREDVQALLAARDRDGAAPIRGIIHAAGITNDQLVTSMTGDAVR
Rv2931|M.tuberculosis_H37Rv         VAADVGCREDVQALLAARDRDGAAPIRGIIHAAGITNDQLVTSMTGDAVR
MLBr_02357|M.leprae_Br4923          VAVDVGHHDDVQALLAKRDRDGAAPIRGIIHAAGVTNDQLVTNMTDDPVR
MMAR_1776|M.marinum_M               EAADATDEAAMTALFDRFGAD-LPPLEGIYLAAFAGGPVLLNEMTDADVR
MUL_2019|M.ulcerans_Agy99           EAADATDEAAMTALFDRFGAD-LPPLDGIYLAAFAGGPVLLNEMTDADVR
TH_2454|M.thermoresistible__bu      AALDIGAPGAAARLR--EVLADLPDVRGVIHAAGVEAGALLTNTTAEDIE
MAB_3148c|M.abscessus_ATCC_199      ALGDIAEPDTAQRLVAAATETGKPVRGVLHAAALVHDATLANITDELIDR
MAV_2370|M.avium_104                ERGDIAEAGTAQRLLDVATATGLPVRGVLHLAAVIEDATLANITDELIER
MSMEG_6767|M.smegmatis_MC2_155      ASVDITDSDQVRAWLREHTGSGGRPVRGIVHAAGSVRDQLLVNMGEDDFA
                                       *                        :  .*      *          

Mflv_3395|M.gilvum_PYR-GCK          RTLWPKVAGARVLH----ELFPTDSVDFLYLTASAGTVFGVPGQGAYAAG
Mvan_3128|M.vanbaalenii_PYR-1       RTVWPKIAGAKVLD----ELFPPGSLDFLYLAASAGAVFGIPGQGAYAAG
Mb2956|M.bovis_AF2122/97            QVMWPKIGGSQVLH----DAFPPGSVDFFYLTASAAGIFGIPGQGSYAAA
Rv2931|M.tuberculosis_H37Rv         QVMWPKIGGSQVLH----DAFPPGSVDFFYLTASAAGIFGIPGQGSYAAA
MLBr_02357|M.leprae_Br4923          QVMWPKIAGCQVLH----EAFPPGSVDFFYLTSSAAGIFGIPGQGSYAAA
MMAR_1776|M.marinum_M               AMFAPKLDAAALLH----RLSLKVPARHFVLFSSISGLIGSRWLAHYTAT
MUL_2019|M.ulcerans_Agy99           AMFAPKLDAAALLH----RLSLKVPARHFVLFSSISGLIGSRWLAHYTAT
TH_2454|M.thermoresistible__bu      ATMRPKVDGVLALH----EVFPPGRLDWLVLFSSCGYLGGFPGQGAYACG
MAB_3148c|M.abscessus_ATCC_199      GDWRPKVHGAWNLH----EATADQPLDWFCSFSSIAALVGSPGQGAYAAA
MAV_2370|M.avium_104                -DWAAKVYGAWNLHCALQESGAEQSLDWFCSFSSAAALVGSPGQGAYAAA
MSMEG_6767|M.smegmatis_MC2_155      EVLAPKITGTRVLHN----VFEDHDLEFFVMFGSAGSTIAAPGQGNYAAA
                                        .*: .   *.              :   .* .   .    . *:. 

Mflv_3395|M.gilvum_PYR-GCK          NAYLDGLARARRREGGVTASLDWVAWRGLG---FGSDAQVVIDELERQGS
Mvan_3128|M.vanbaalenii_PYR-1       NAYLDALARSRHHRGDNTVSLDWVAWQGLG---FGSEAQVVVSELERVGS
Mb2956|M.bovis_AF2122/97            NSYLDALARARRQQGCHTMSLDWVAWRGLG---LAADAQLVSEELARMGS
Rv2931|M.tuberculosis_H37Rv         NSYLDALARARRQQGCHTMSLDWVAWRGLG---LAADAQLVSEELARMGS
MLBr_02357|M.leprae_Br4923          NSYLDALARTRRQQGCHTMSIDWVAWRGLG---FAANAQIVSDELQRMGS
MMAR_1776|M.marinum_M               SGYLDALAYARHALGLPATTVNWGLWKSLADAEHDASQVSVGSGLLPMQD
MUL_2019|M.ulcerans_Agy99           SGYLDALAYARHALGLPATTVNWGLWKSLADAEHDASQVSVGSGLLPMQD
TH_2454|M.thermoresistible__bu      NAYLDAFARYRRASGDATTSVAWTAWRGLG---MGSASDFVAAQLDALGM
MAB_3148c|M.abscessus_ATCC_199      NSWLDGFTHWRRAQGLPATVIAWGAWSEIG----------QGTHLAQNAE
MAV_2370|M.avium_104                NSWLDAFTRWRRARGLKATAIAWGAWAQIG----------RGAALADSAD
MSMEG_6767|M.smegmatis_MC2_155      NAFLDAFAHHRQGLGLPALTIGWGPWSVGM-----VEELGLEKVYAQRGI
                                    ..:**.::  *:  *  :  : *  *                        

Mflv_3395|M.gilvum_PYR-GCK          RPVTPAEAFAAWEYASRFDVAHVVMAPTLDADEDTD-----------QAA
Mvan_3128|M.vanbaalenii_PYR-1       RPVVPAEAFAAWDFVTRFDVAQVVMAPMQSAEDAAA-----------VTA
Mb2956|M.bovis_AF2122/97            RDITPSEAFTAWEFVDGYDVAQAVVVPMPAPAGADG----------SGA-
Rv2931|M.tuberculosis_H37Rv         RDITPSEAFTAWEFVDGYDVAQAVVVPMPAPAGADG----------SGA-
MLBr_02357|M.leprae_Br4923          RDITPSEAFTAWEYVDAYDVAQAVVLPVPRSYGSAG----------STAG
MMAR_1776|M.marinum_M               EVAIGTLPLLMNPAAGVHSVVVEADWPLLAAAYRTRGSLHIVDDLLRDFA
MUL_2019|M.ulcerans_Agy99           EVAIGTLPLLMNPAAGVHSVVVEADWPLLAAAYRTRWSLHIVDDLLRDFA
TH_2454|M.thermoresistible__bu      GTVDVDDAMRALDAAIRDGDPNVVVLPLSPAAAAVPMFADVAPADPDADA
MAB_3148c|M.abscessus_ATCC_199      AAILPDEGAYAFDTVLRHNRAYTAYAPMAGISWLADFVER------SPFA
MAV_2370|M.avium_104                VAITPDEGAYAFEALLRHDRACTGYAPITGTPWLTAFAQR------SPFA
MSMEG_6767|M.smegmatis_MC2_155      ELITPAVGARIIDRLLSQSVPAVVAMNADWSRARQVGFGGLVPKMFGELG
                                                      .                               

Mflv_3395|M.gilvum_PYR-GCK          ESG--PERDWSQMSAD---------DVVSELESGLRTILAVELRIGDD-E
Mvan_3128|M.vanbaalenii_PYR-1       DTHRAPTRDWTAMAPD---------ELLAELQDGLRGILATELRLPES-D
Mb2956|M.bovis_AF2122/97            NAYLLPARNWSVMAAT---------EVRSELEQGLRRIIAAELRVPEK-E
Rv2931|M.tuberculosis_H37Rv         NAYLLPARNWSVMAAT---------EVRSELEQGLRRIIAAELRVPEK-E
MLBr_02357|M.leprae_Br4923          DSYLVPARNWSQMEAA---------EVRKELESGLRTIIAAELRVAEA-E
MMAR_1776|M.marinum_M               EASTIPARDWSHLSAQ---------EVRTEFEAGLRRIVARELRVSES-D
MUL_2019|M.ulcerans_Agy99           EASTIPARDWSHLSAQ---------EVRTEFEAGLRRIVARELRVSES-D
TH_2454|M.thermoresistible__bu      PGGEVPDGLSDGFPADGFPDD---GDLAEWVHRRVIAAVAGELGLAET-D
MAB_3148c|M.abscessus_ATCC_199      QAFRDAGQNQTETNKFLDELR---ALPREEWPTRLRKLVAEQVGLVLRRS
MAV_2370|M.avium_104                EAFRANGQSATGTSKLRAELE---ELPPEEWSTRLRRLISDQVSLILRRN
MSMEG_6767|M.smegmatis_MC2_155      TADTVGGQDGVGPSILELLAHTADADRPAVIAEQVRRLVAAVFDCAVT-D
                                                                      :   ::  .      .

Mflv_3395|M.gilvum_PYR-GCK          VDSDRPLAEMGLNSVMAMSIRREVEKLAGIELSATMLWNYPTIGALAAYL
Mvan_3128|M.vanbaalenii_PYR-1       VHTDRPFAEMGLNSVMAMSIRREVERLVGLELSATMLFNHPTIESFASYL
Mb2956|M.bovis_AF2122/97            LDTDRPFAELGLNSLMAMAIRREAEQFVGIELSATMLFNHPTVKSLASYL
Rv2931|M.tuberculosis_H37Rv         LDTDRPFAELGLNSLMAMAIRREAEQFVGIELSATMLFNHPTVKSLASYL
MLBr_02357|M.leprae_Br4923          LDTDRPFAELGLNSLMAMAIRREAEQFIGIELSAIMLFNHPTVALLAAYL
MMAR_1776|M.marinum_M               LETDRPLAELGLNSLMAMAIRREAEMFVGIELSATMLFNHPTVASLASYL
MUL_2019|M.ulcerans_Agy99           LETDRPLAELGLNSLMAMAIRREAEMFVGIELSATMLFNHPTVASLASYL
TH_2454|M.thermoresistible__bu      VDPRLPLVEIGVDSIMTVALRRQLERQTGLTLPPTLLWEHPTAGAVSDRI
MAB_3148c|M.abscessus_ATCC_199      IDPDRSLPDYGLDSLGNLEIRTRIQADTGVRIGPADVS---TVRSLAAHI
MAV_2370|M.avium_104                VDPDRPLPEYGLDSLGGLELLTRIQTETGIRVSPADIAAIGTIRGLADLL
MSMEG_6767|M.smegmatis_MC2_155      IEPDDMLDDIGLDSMMAMDFRVRINSAFSIDLPVLEILRGVSVNSLSARI
                                    :..   : : *::*:  : :  . :   .: :    :    :   .:  :

Mflv_3395|M.gilvum_PYR-GCK          AEKVAPQ-----------------AVA----EAAEEDSGDSLLDSLFDSV
Mvan_3128|M.vanbaalenii_PYR-1       AQQLAPE-----------------TGGD---DEVADDSGGSLLDSLFDSV
Mb2956|M.bovis_AF2122/97            AKRVAPH-----------------DVSQDNQISALSSSAGSVLDSLFDRI
Rv2931|M.tuberculosis_H37Rv         AKRVAPH-----------------DVSQDNQISALSSSAGSVLDSLFDRI
MLBr_02357|M.leprae_Br4923          TKVVAPQ-----------------HDSQGDEMAALSASAGGVLDSLFDRI
MMAR_1776|M.marinum_M               ANRVAPQ-----------------DNSSNDQMAELSASAGSTLDSLFDRI
MUL_2019|M.ulcerans_Agy99           ANRVAPQ-----------------DNSSNDQMAELSASAGSTLDSLFDRI
TH_2454|M.thermoresistible__bu      VEMLRAR-----------------G-------------------------
MAB_3148c|M.abscessus_ATCC_199      YDRLAEQ-----------------ESEVASS-------------------
MAV_2370|M.avium_104                RDKLTPA-----------------GAAQAERV------------------
MSMEG_6767|M.smegmatis_MC2_155      LAELRDIHGVAPVEPDTGETASEPTTTDDDVERLLQDLSEAEMRQLLAEL
                                       :                                              

Mflv_3395|M.gilvum_PYR-GCK          EN----------
Mvan_3128|M.vanbaalenii_PYR-1       EN----------
Mb2956|M.bovis_AF2122/97            ESAPPEAERSV-
Rv2931|M.tuberculosis_H37Rv         ESAPPEAERSV-
MLBr_02357|M.leprae_Br4923          ESTSTEAEGLV-
MMAR_1776|M.marinum_M               ESSSLLPEGPG-
MUL_2019|M.ulcerans_Agy99           ESSSLLPEGPG-
TH_2454|M.thermoresistible__bu      ------------
MAB_3148c|M.abscessus_ATCC_199      ------------
MAV_2370|M.avium_104                ------------
MSMEG_6767|M.smegmatis_MC2_155      EASGTEAGGAIS