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MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLADLGVSSRDAVVLSGELSELLGRTVSPIDFWEHP TINALAAYLAAPEPSPDSDAAVKRGARNSLDEPIAVVGMGCRFPGGISCPEALWDFLCERRSSISQVPPQ RWQPFEGGPPEVAAALARTTRWGSFLPDIDAFDAEFFEISPSEADKMDPQQRLLLEVAWEALEHAGIPPG TLRRSATGVFAGACLSEYGAMASADLSQVDGWSNSGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAI HLACQSLRTQDCHLAIAAGVNLLLSPAVFRGFDQVGALSPTGQCRAFDATADGFVRGEGAGVVVLKRLTD AQRDGDRVLAVICGSAVTQDGRSNGLMAPNPAAQMAVLRAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEA RALGTVLGRGRPEDSPLLIGSVKTNLGHTEAAAGIAGFIKTVLAVQHGQIPPNQHFETANPHIPFTDLRM KVVDTQTEWPATGHPRRAGVSSFGFGGTNAHVVIEQGQEVRPAPGQGLSPAVSTLVVAGKTMQRVSATAG MLADWMEGPGADVALADVAHTLNHHRSRQPKFGTVVARDRTQAIAGLRALAAGQHAPGVVNPAEGSPGPG TVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQAGFSLHDVLANGEELVGIEQIQLGLIGMQL ALTELWCSYGVQPDLVIGHSMGEVAAAVVAGALTPAEGLRVTATRSRLMAPLSGQGGMALLELDAPTTEA LIADFPQVTLGIYNSPRQTVIAGPTEQIDELITRVRARDRFASRVNIEVAPHNPAMDALQPAMRSELADL TPRTPTIGIISTTYADLHTQPVFDAEHWATNMRNPVHFQQAIASAGSGADGAYHTFIEISAHPLLTQAII DTLHSAQPGARYTSLGTLQRDTDDVVTFRTNLNKAHTIHPPHTPHPPEPHPPIPTTPWQHTRHWITTKYP AGSVGSAPRAGTLLGQHTTVATVSASPPSHLWQARLAPDAKPYQGGHRFHQVEVVPASVVLHTILSAATE LGYSALSEVRFEQPIFADRPRLIQVVADNRAISLASSPAAGTPSDRWTRHVTAQLSSSPSDSASSLNEHH RANGQPPERAHRDLIPDLAELLAMRGIDGLPFSWTVASWTQHSSNLTVAIDLPEALPEGSTGPLLDAAVH LAALSDVADSRLYVPASIEQISLGDVVTGPRSSVTLNRTAHDDDGITVDVTVAAHGEVPSLSMRSLRYRA LDFGLDVGRAQPPASTGPVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAIIGDDGAALCETL EGAGYQPAVMSDGVSQARYVVYVADSDPAGADETDVDFAVRICTEITGLVRTLAERDADKPAALWILTRG VHESVAPSALRQSFLWGLAGVIAAEHPELWGGLVDLAINDDLGEFGPALAELLAKPSKSILVRRDGVVLA PALAPVRGEPARKSLQCRPDAAYLITGGLGALGLLMADWLADRGAHRLVLTGRTPLPPRRDWQLDTLDTE LRRRIDAIRALEMRGVTVEAVAADVGCREDVQALLAARDRDGAAPIRGIIHAAGITNDQLVTSMTGDAVR QVMWPKIGGSQVLHDAFPPGSVDFFYLTASAAGIFGIPGQGSYAAANSYLDALARARRQQGCHTMSLDWV AWRGLGLAADAQLVSEELARMGSRDITPSEAFTAWEFVDGYDVAQAVVVPMPAPAGADGSGANAYLLPAR NWSVMAATEVRSELEQGLRRIIAAELRVPEKELDTDRPFAELGLNSLMAMAIRREAEQFVGIELSATMLF NHPTVKSLASYLAKRVAPHDVSQDNQISALSSSAGSVLDSLFDRIESAPPEAERSV
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2956 | ppsA | - | 100% (1876) | phenolpthiocerol synthesis type-I polyketide synthase PPSA |
M. bovis AF2122 / 97 | Mb2957 | ppsB | 0.0 | 69.08% (938) | phenolpthiocerol synthesis type-I polyketide synthase PPSB |
M. bovis AF2122 / 97 | Mb2958 | ppsC | 0.0 | 46.32% (1561) | phenolpthiocerol synthesis type-I polyketide synthase PPSC |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_3395 | - | 0.0 | 55.35% (1888) | acyl transferase domain-containing protein |
M. tuberculosis H37Rv | Rv2931 | ppsA | 0.0 | 99.63% (1876) | phenolpthiocerol synthesis type-I polyketide synthase PPSA |
M. leprae Br4923 | MLBr_02357 | - | 0.0 | 75.85% (1888) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 37.29% (1086) | polyketide synthase |
M. marinum M | MMAR_1776 | ppsA | 0.0 | 84.17% (992) | phenolpthiocerol synthesis type-I polyketide synthase PpsA |
M. avium 104 | MAV_2370 | - | 0.0 | 34.62% (1430) | mycocerosic acid synthase |
M. smegmatis MC2 155 | MSMEG_6767 | - | 0.0 | 30.95% (1877) | mycocerosic acid synthase |
M. thermoresistible (build 8) | TH_2454 | - | 0.0 | 36.56% (1819) | PUTATIVE beta-ketoacyl synthase |
M. ulcerans Agy99 | MUL_2019 | ppsA | 0.0 | 83.97% (992) | phenolpthiocerol synthesis type-I polyketide synthase PpsA |
M. vanbaalenii PYR-1 | Mvan_3128 | - | 0.0 | 57.60% (1887) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment MAB_0939|M.abscessus_ATCC_1997 MDSAENPIESTPRFAIIGYAARFPGAADAEEFWDVLREGRDAISEVPADR MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 WDAEEFFDPEPGAPGKVVTRRAGFVEDVTGFDAPFFGMSTREVRLMDPQH MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 RLLLETAWRAVEHSGIAPTDLAETNSGVFVGLATHDYLGMASDELTFPEI MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EAYMAIGTSNAAAAGRISYRLGLQGPSVAVDTACSSSLVAIHQACQALQL MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GECDLALAGGANVLLTPATMITFSHAHMLAPDGKCKTFDAAADGYVRGEG MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SGVIVIKRLEDAIRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DALKRAGVAPSEVGYLEAHGTGTSLGDPIEAQAAGAAYGIGRETNDPLLI MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GSAKTNIGHLEAAAGIAGVIKVILSLENELLPQHRNFQNPSPHIPWDRLP MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VEVVREARPWGRNGRPRIAGVSSFGFAGTNAHVILEEAPVVSRDAVEPPA MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PAGGRKFSILPLSARTPAALAQLADKYRAWLNAHPEAALADLCFTAGVGR MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AHLEHRAALVVNTREAAVELLSAVADDRPAPGLGRGESHDTPKTAWLFTG MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 QGSQYPGMARELFETEPVFADTLNRCAAAVADVLEKPLLDVIFDVDGPEA MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EETLRQTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAACVAE MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VFSLEDGARLIAERGRLFSSLPAGGRMAAVFTDAERAERLTDEFPSLSVA MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AYNGANTVLSGPAQDLEKAIAALVADGVRCDFLETSHAFHSALLDPILDE MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 FEAYANQFNYKTPQRILIDNRTGTALGRSVKLDGAYWRRHARQPVEFAKS MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VRTLADMNCKVLLEIGPQPVLTAAALRAWPDPATAPRAIASLRRNTADHR MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 QITEAAADAYVLGHLPDFGAFQHAPARKLDLPTYPFERRQYWFSDKRDGD MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 NRDAGNRQQNNGGPRTEAVRLLEDGKIEELANLLGGVDGDQQTLNVLTKL MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AAQHNLQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVADAAGAA MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 QPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAADEDSALRIVHVAA MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LAGQGSSSAQSLLRIQHQVLGGTRRLFRAAAAAELRAPIWIVTRGAQHVI MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EGDTVAPEQSALWGFGRAAALELPQVWGGLADLSDAGTDEWAQFIGRVSV MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SGEASTREDQLALRGQAVHVPRLVRREELPSGKPLEVRSDATYLVTGGLG MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SIGLEIAGYLAGRGAKHLVLTSRREPGEAARQRIDALAAQGCEVRAVTAD MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VADGHDVARLLAGIQAELPPLAGIVHAAGEIGTTPLSDLEDAEVDRVFAG MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 KVWGAWHLSEAAAGLKLDFFINTSSIAAVWGGYGQTAYSAANAFLDGLAW MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 RLREQGIAGTSVNFGPWSAGMADAESRARLEQRGIKTLSPTDALAGLADV MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VAASGSNAVQGVIARIDWARFLPLYQQAGKRGFLAELDREVPSHLAGVAG MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAEVTRVDVSEIREDAGFF MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLA Rv2931|M.tuberculosis_H37Rv -------------MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLA MLBr_02357|M.leprae_Br4923 -------------MTASIGSEADLCHWLVNYLVTNIGCTPDEVDLNLSLT MMAR_1776|M.marinum_M -------------MTPSIGGEADLRHWLVDYLVTNIGCPPDEVDPNLSLA MUL_2019|M.ulcerans_Agy99 -------------MTPSIGGEADLRHWLVDYLVTNIGCPPDEVDPNLSLA Mflv_3395|M.gilvum_PYR-GCK -------------MTSAFD-EDAIRNWLVDYLVTNIGCSPDEIDFDAPLN Mvan_3128|M.vanbaalenii_PYR-1 -------------MTSAFD-EDAIRNWLVDYLVTNIGCSPDEINFDAPLN TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DLGMDSLMAVELRRRMEQGVGKEIPVTLVMDHPRISDVADYLLGDVLGLA MAV_2370|M.avium_104 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 DLGVSSRDAVVLSGELSELLGRTVSPIDFWEHPTINALAAYLAAPEPSPD Rv2931|M.tuberculosis_H37Rv DLGVSSRDAVVLSGELSELLGRTVSPIDFWEHPTINALAAYLAAPEPSPD MLBr_02357|M.leprae_Br4923 DLGMSSRDAVVLSGELTDLLGKTVSPIDFWEHPTINALAAYLIAPAPDPE MMAR_1776|M.marinum_M DLGVSSRDAVVLSGELTELLGRTVSPIDFWEHPTINDLAAYLTAPEPSTG MUL_2019|M.ulcerans_Agy99 DLGVSSRDAVVLSGELTELLGRTVSPIDFWEHPTINDLAAYLTAPEPSTG Mflv_3395|M.gilvum_PYR-GCK DLAVGSSDAVVLTGELSELLGRTVSPVEFWQYPTINALARFLTGGEVEAV Mvan_3128|M.vanbaalenii_PYR-1 DLAVGSSDAVVLTGELSELLGRTVSPVEFWQYPTINALAKFLTGGEVEPA TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EQAKPAAQLASAVTGRTDEPIAIVAVSCRFPGAPD-------PEAFWDVL MAV_2370|M.avium_104 -----------------MVPVAVIGMACRLPGAVDS------PERLWEAL Mb2956|M.bovis_AF2122/97 SDAAVKRGAR----NSLDEPIAVVGMGCRFPGG------ISCPEALWDFL Rv2931|M.tuberculosis_H37Rv SDAAVKRGAR----NSLDEPIAVVGMGCRFPGG------ISCPEALWDFL MLBr_02357|M.leprae_Br4923 SESAPRRSVQ----GALEEPIAVIGMGCRFPGG------ISGPEALWQFL MMAR_1776|M.marinum_M AEAAVSRTVR----GSLEEPIAVVGMGCRFPGG------ISGPEALWQFL MUL_2019|M.ulcerans_Agy99 AEAAVSRTVR----GSLEEPIAVVGMGCRFPGG------ISGPEALWQFL Mflv_3395|M.gilvum_PYR-GCK AEVSPIRRVS-------DDAIAVVGLGVRFPGGG---DDIHGPDDLWEFL Mvan_3128|M.vanbaalenii_PYR-1 IEASVGGGVSRDY-GADDEPIAVIGLGCRFPGGDGLDGNITGPDAYWRFL TH_2454|M.thermoresistible__bu MSVDVTAKAR------PDDPIAIIGIGCRLAGR------ITSPEEFWGFL MSMEG_6767|M.smegmatis_MC2_155 MPMPNTDHTS-------RQPLAIVGIGCRFPGG------ADSAQRYWDLL .:*::.:. *:.* .: * * MAB_0939|M.abscessus_ATCC_1997 SGGVDAIREVPEDRFDIDEFYDPDPEVAGKTYTRFGGFLDGIDGFDPEFF MAV_2370|M.avium_104 LRGDDFVTEIPPDRWDADEYYDPEPGVPGRSVSRWGAFIDDVAGFDPEFF Mb2956|M.bovis_AF2122/97 CERRSSISQVPPQRWQPFEGGPPEVAAALARTTRWGSFLPDIDAFDAEFF Rv2931|M.tuberculosis_H37Rv CERRSSISQVPPQRWQPFEGGPPEVAAALARTTRWGSFLPDIDAFDAEFF MLBr_02357|M.leprae_Br4923 CDRRSSIGQVPNERWELFDDGSPEVKALLARTTRWGSFLEDIDAFDSEFF MMAR_1776|M.marinum_M CDRKSSIGRVPDERWAQFDDGSPAVKALLARTTRWGSYLTDIDAFDADFF MUL_2019|M.ulcerans_Agy99 CDRKSSIGRVPDERWAQFDDGSPAVKALLARTTRWGSYLTDIDAFDADFF Mflv_3395|M.gilvum_PYR-GCK AQGRSAVSQVPPTRWSWYDDGSPEGAAALAHTTRWGSYLSEIDEFDADYF Mvan_3128|M.vanbaalenii_PYR-1 MEGRSAVRQVPEERWESFQINTPEAAAALAGTTRWGAFLRDLDAFDAEFF TH_2454|M.thermoresistible__bu LAGGSNVREIPAERWEPYLRRDPRNAAVLREITPWGTFLDDLAGFDAEFF MSMEG_6767|M.smegmatis_MC2_155 CNNIDATREVPENRWNAAKYHDPNPAKIGKIVTRRGGFLDQIDQFDPQFF . .:* *: * : * :: : **.::* MAB_0939|M.abscessus_ATCC_1997 GISPREAVWIEPQQRLMLETVWEGLERAGYSPAALRGSRTGIFAGVGANE MAV_2370|M.avium_104 GINEREATAMDPQHRLLLETSWEAMEHAGLTEERVADSRTGVFIGLTHGD Mb2956|M.bovis_AF2122/97 EISPSEADKMDPQQRLLLEVAWEALEHAGIPPGTLRRSATGVFAGACLSE Rv2931|M.tuberculosis_H37Rv EISPSEADKMDPQQRLLLEVAWEALEHAGIPPGTLRRSATGVFAGACLSE MLBr_02357|M.leprae_Br4923 EISPSEADKMDPQQRLLLEVAWEALEHAGISSNSLRRSQTGVFAGSCLSE MMAR_1776|M.marinum_M EISASEADKMDPQQRLLLEVAWEALEHAGIPPSSLRRSQTGVFAGSCLSE MUL_2019|M.ulcerans_Agy99 EISASEADKMDPQQRLLLEVAWEALEHAGIPPSSLRRSQTGVFAGSCLSE Mflv_3395|M.gilvum_PYR-GCK EISPSEADKMDPQQRLLLEVTHEALEHAGIRPDVLRHTQTGVFVGACLGE Mvan_3128|M.vanbaalenii_PYR-1 EISPSEADKMDPQQRLLLEVTQEALEHAGIPTHTLRHSQTGVFAAACLGE TH_2454|M.thermoresistible__bu GVSPREAELTDPQQRLALEVSWEALEHAGVPPRSLAGTDTAVLMGVNSDD MSMEG_6767|M.smegmatis_MC2_155 GISPREAHSLDPQQRLLLQATWEALEDGGIPADELAGTDVGVFVGGFTLD :. ** :**:** *:. *.:* .* : : ..:: . : MAB_0939|M.abscessus_ATCC_1997 YAHLLSSES--IDKIEPYFITGNALNAISGRVAFALGFEGPAVAVDTACS MAV_2370|M.avium_104 Y-QLLAADT--RSVEGAYGFSGSNFSLASGRIAYALGVHGPALTVDTACS Mb2956|M.bovis_AF2122/97 YGAMASAD---LSQVDGWSNSGGAMSIIANRLSYFLDLRGPSVAVDTACS Rv2931|M.tuberculosis_H37Rv YGAMASAD---LSQVDGWSNSGGAMSIIANRLSYFLDLRGPSVAVDTACS MLBr_02357|M.leprae_Br4923 YGAIASTD---LSQVDGWSNTGGAMSIIANRLSYFLDLRGPSVAVDTACS MMAR_1776|M.marinum_M YGAIASTD---LTQVDGWSNTGGAMSIIANRLSYFLDLRGPSVAVDTACS MUL_2019|M.ulcerans_Agy99 YGAIASTD---LTQVDGWSNTGGAMSIIANRLSYFLDLRGPSVAVDTACS Mflv_3395|M.gilvum_PYR-GCK YAVMASKD---LAEVNAYSGTGGALSIIANRVSYFYDLRGPSVTIDTACS Mvan_3128|M.vanbaalenii_PYR-1 YGYLSTVD---LGDVDSWSGTGGALSIIANRVSYYFDLRGPSVTIDTACS TH_2454|M.thermoresistible__bu YGRLLMED---LPGIEAWTGIGTSLCGIANRVSHLLDLRGPSVALDAACA MSMEG_6767|M.smegmatis_MC2_155 YQLLQNQGRTSRYRFKPHSATGMMMTMLANRISHAFDFRGPSMAIDTACS * : * : :.*::. ...**::::*:**: MAB_0939|M.abscessus_ATCC_1997 SALVAVHQAVQALHSGDCDLALAGGVNVLLSPVTVIAASRARMLSPVGRC MAV_2370|M.avium_104 SGLTAIHLACRSLHEGESDLALAGGATLALDPRKFSAGSAEGMLSPTGRC Mb2956|M.bovis_AF2122/97 SSLVAIHLACQSLRTQDCHLAIAAGVNLLLSPAVFRGFDQVGALSPTGQC Rv2931|M.tuberculosis_H37Rv SSLVAIHLACQSLRTQDCHLAIAAGVNLLLSPAVFRGFDQVGALSPTGQC MLBr_02357|M.leprae_Br4923 SSLVAIHLACQSLRTADANLAIAAGVNLLLSPAVFRGFDQVGALSPTGCC MMAR_1776|M.marinum_M SSLVAIHLACQSLRMQDSNLAIAAGVNLLLSPAVFRGFDQVGALSPTGNC MUL_2019|M.ulcerans_Agy99 SSLVAIHLACQSLRMQDSNLAIAAGVNLLLSPAVFRGFDQVGALSPTGNC Mflv_3395|M.gilvum_PYR-GCK SSLVAIHLACQSLRSGDSDVALAGGVNVILSPAVTRSFDQAEAMSKSGRC Mvan_3128|M.vanbaalenii_PYR-1 SSLVTIHLACQSLRSGDSNMALAAGVNLLLSPAVTRSFDQLEAMSRTGQC TH_2454|M.thermoresistible__bu ASLVAVHNACQLLRAGETGLAIAGGVSALIGPGLTRVLDKAGATAPDGRC MSMEG_6767|M.smegmatis_MC2_155 SSLVAVHLAAQSIWDGDCDVALAGGVNIMVGPNTAIAESKSGFLSPEGRS :.*.::* * : : : :*:*.*.. :.* . : * . MAB_0939|M.abscessus_ATCC_1997 KTFDASADGYVRSEGCGILVLKRLSDAERDGDRVLAVIPGSAVNQDGASS MAV_2370|M.avium_104 HAFDVAADGFVGGEGSVMLLLKRLNDALRDGDRILAVVRGTAANQDGHTV Mb2956|M.bovis_AF2122/97 RAFDATADGFVRGEGAGVVVLKRLTDAQRDGDRVLAVICGSAVTQDGRSN Rv2931|M.tuberculosis_H37Rv RAFDATADGFVRGEGAGVVVLKRLTDAQRDGDRVLAVICGSAVNQDGRSN MLBr_02357|M.leprae_Br4923 RAFDAAADGFVRGEGAGVVVLKRLTDAQRDGDRVLAIIRGSAVNQDGRSN MMAR_1776|M.marinum_M RAFDAAADGFVRGEGAGVVVLKRLTDAQQDGDRVLAVICGSAINQDGRSN MUL_2019|M.ulcerans_Agy99 RAFDAAADGFVRGEGAGVVVLKRLTDAQQDGDRVLAVICGSAINQDGRSN Mflv_3395|M.gilvum_PYR-GCK HAFDSRADGFVRGEGCGVAVLKRLSDAQRDGDRVLAVVRGSAVNQDGRSN Mvan_3128|M.vanbaalenii_PYR-1 HAFDAGADGFVRGEGCGVTVLKRLSDAQRDGDRILAVIRGSAVNQDGRSN TH_2454|M.thermoresistible__bu KSFDASADGYGRGEGAAVVILKRLPDALRDGDRVIAVIRGGAVAQDGRTV MSMEG_6767|M.smegmatis_MC2_155 KAFSDTADGYARGEGGAVVVIKPLAHALRDGDDIYAQILGTAVSQDGHTD ::*. ***: .** : ::* * .* :*** : * : * * *** : MAB_0939|M.abscessus_ATCC_1997 GLTVPNGGAQQRLIGSVLARAGLVGGDVDYLEAHGTGTPLGDPIEVQAAA MAV_2370|M.avium_104 NIATPSKTAQTAVYRAALAAAGVDAGTVGMVEAHGPGTPVGDPIEYASLA Mb2956|M.bovis_AF2122/97 GLMAPNPAAQMAVLRAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALG Rv2931|M.tuberculosis_H37Rv GLMAPNPAAQMAVLRAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALG MLBr_02357|M.leprae_Br4923 GLMAPNPAAQVAVLRTAYANAAMPPTAIDYVETHGTGTLLGDPIEARALG MMAR_1776|M.marinum_M GLMAPNPAAQQAVLRAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALG MUL_2019|M.ulcerans_Agy99 GLMAPNPAAQQAVLRAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALG Mflv_3395|M.gilvum_PYR-GCK GLMAPNPAAQMSVLRSAYAAAGVEPREVDYIEAHGTGTLLGDPIEARALG Mvan_3128|M.vanbaalenii_PYR-1 GLMAPNPAAQMAVLRSAYSAAGVEPRDVDYVETHGTGTLLGDPIEARALG TH_2454|M.thermoresistible__bu GIMSPNGAAQRDLFRHTCEITGTSPATVDFVEAHGTGTPTGDPVELDALA MSMEG_6767|M.smegmatis_MC2_155 GITVPNEEAQEAAIRMALQRAGVEPNDVAYVEAHGTGTPVGDPIEMRALA .: *. ** . :. : :*:**.** ***:* : . MAB_0939|M.abscessus_ATCC_1997 AAYGGSRDADRPLLMGSVKSNIGHTESASGAAGLIKVVLSLQNGVLPQSL MAV_2370|M.avium_104 EVYG----IDGPCALASVKTNFGHAQAASGALGMMKAILALQHGVVPRNL Mb2956|M.bovis_AF2122/97 TVLGRGRPEDSPLLIGSVKTNLGHTEAAAGIAGFIKTVLAVQHGQIPPNQ Rv2931|M.tuberculosis_H37Rv TVLGRGRPEDSPLLIGSVKTNLGHTEAAAGIAGFIKTVLAVQHGQIPPNQ MLBr_02357|M.leprae_Br4923 AVLGRGRAEDSPLLIGAVKTNLGHLEAAAGIAGFIKTVLAVQRGQIPPNQ MMAR_1776|M.marinum_M SVLGRGRPEESPLLIGAVKTNLGHTEAAAGIAGFIKAVLAVQHGRIPPNQ MUL_2019|M.ulcerans_Agy99 SVLGRGRPEESPLLIGAVKTNLGHTEAAAGIAGFIKAVLAVQHGRIPPNQ Mflv_3395|M.gilvum_PYR-GCK SVLGRGRAADAPLLIGAIKSNLGHTEAAAGIAGFAKTVLALQRGRIPANL Mvan_3128|M.vanbaalenii_PYR-1 TVLGRGRAADAPLLLGAVKSNLGHLEAAAGVAGFIKAVLALQHQQIPANL TH_2454|M.thermoresistible__bu AVYGAAHGPDDPCRVGSVKPNTGHLEGGAGVVGLIKAALALQHGVIPPTA MSMEG_6767|M.smegmatis_MC2_155 GALTTDRDATRPLVIGSVKTNIGHLEAGAGVAGLIKAALIVKHGHIPANL . * :.::*.* ** :..:* *: *. * ::. :* . MAB_0939|M.abscessus_ATCC_1997 HFDNPSPHIPWESLPVRVVDKAIPWQANG-RPRRAGVSSFGFTGTNAHVL MAV_2370|M.avium_104 HFTQLPDDLARIDTKLFVPQQTTPWVSNGGHPRRAAVSSYGLSGTNVHAI Mb2956|M.bovis_AF2122/97 HFETANPHIPFTDLRMKVVDTQTEW-PATGHPRRAGVSSFGFGGTNAHVV Rv2931|M.tuberculosis_H37Rv HFETANPHIPFTDLRMKVVDTQTEW-PATGHPRRAGVSSFGFGGTNAHVV MLBr_02357|M.leprae_Br4923 RFESPNLHIPFAELRMKVVDKHMEW-PDTGHLRRAAVSSFGFGGTNAHVV MMAR_1776|M.marinum_M RFESPNPHIAFADLRMKVVDELTDW-PDTGHPRRAGVSSFGFGGTNAHVV MUL_2019|M.ulcerans_Agy99 RFESPNPHIAFADLRMKVVDELTDW-PDTGHPRRAGVSSFGFGGTNAHVV Mflv_3395|M.gilvum_PYR-GCK DYQSPNPHIPFDNLRLKVVDEVTDW-KPVGRPRVAGVSSFGFGGTNAHVV Mvan_3128|M.vanbaalenii_PYR-1 GYEKPNPHIPFDNLRLKVIAEHTEWPAPAGRPRRAGVSSFGFGGTNAHVV TH_2454|M.thermoresistible__bu GIRELTPAVDWATNGLHVPTTVEPFPRRADSPRRAAVCSYGYGGTIAHLL MSMEG_6767|M.smegmatis_MC2_155 HLKNPTRHVSLTELKLDIPTIGRPF--PECDRRIAGINSFGFGGTNAHVV : : : : * *.: *:* ** .* : MAB_0939|M.abscessus_ATCC_1997 IEEAP-----QPQATPDEDDASTPQSAPVSVLPLSARSPEALAAVAQRYE MAV_2370|M.avium_104 LEQAP-----EPAPETVAPEGISAESP--LLFPLSSTSADELRRTAGRLA Mb2956|M.bovis_AF2122/97 IEQG------QEVRPAPGQGLSPA----VSTLVVAGKTMQRVSATAGMLA Rv2931|M.tuberculosis_H37Rv IEQG------QEVRPAPGQGLSPA----VSTLVVAGKTMQRVSATAGMLA MLBr_02357|M.leprae_Br4923 IEQG------PELTPVTECSSNTA----VSTLVVTGKTASRVAAMAGMLA MMAR_1776|M.marinum_M IEQG------QEAASSPEAGLTPA----LSTLVVAGKTPARVAATAGMLA MUL_2019|M.ulcerans_Agy99 IEQG------QEAASSPEADLTPA----LSTLVVAGKTPARVAATAGMLA Mflv_3395|M.gilvum_PYR-GCK LEQA------PDPTPAEDTDVAPAAASPVTTLVVAGKSAPRIATTAGMLA Mvan_3128|M.vanbaalenii_PYR-1 IEQA------PPKAPATNGQGEPA----VTTLVVSGRTAERIASEAGMLA TH_2454|M.thermoresistible__bu LEEAPAVDETPAAAPAPAADAADANSPRFHVIPVSARSGARLARHAAALR MSMEG_6767|M.smegmatis_MC2_155 LAEP----------PAARHSAETGDHRVLTVLPISARSEEALVATAGRLA : : : ::. : : * MAB_0939|M.abscessus_ATCC_1997 SWLAA--HPDVDLEDVCLTAGRGRSHFEHRAALVVDSIQTAREGLLELAQ MAV_2370|M.avium_104 DWVHA--HGDLALPDLAYTLARRRVHRPVRTAVLAGDRAQLIEALREVAD Mb2956|M.bovis_AF2122/97 DWMEG-PGADVALADVAHTLNHHRSRQPKFGTVVARDRTQAIAGLRALAA Rv2931|M.tuberculosis_H37Rv DWMEG-PGADVALADVAHTLNHHRSRQPKFGTVVARDRTQAIAGLRALAA MLBr_02357|M.leprae_Br4923 DWVEG-PGAEVALADVAHTLNHHRSRHAKFGTVVARDRIQAVAGLRALAA MMAR_1776|M.marinum_M DWMEG-PGAEVALADVAHTLNHHRSRQARFGTVVARERAQAVAGLRALAA MUL_2019|M.ulcerans_Agy99 DWMEG-PGAEVALADVAHTLNHHRSRQARFGTVVARERAQAVAGLRALAA Mflv_3395|M.gilvum_PYR-GCK EWLAG-DGADVPLDQVAHSLNHHRAQHSKFATVCTRDRAGALAGLQALAA Mvan_3128|M.vanbaalenii_PYR-1 EWMAGPEGSLASLPEVAHTLNHHRSHYNKFATVAARDRDQAIAGLRALAA TH_2454|M.thermoresistible__bu GHLSA----GADLTAVAATMWQRRSHEPVRAAVIARHPGELVAGLDAIAT MSMEG_6767|M.smegmatis_MC2_155 GHLAA--HPEVTLADLGYTLSHRRAHLNHRHTFVVDSIDEARRQLQAVAD : . * : : : * : :. . * :* MAB_0939|M.abscessus_ATCC_1997 NRLRPGVVR--GEHTNHPTTAWLFTGQGSQYPGMARELFDAEPVFAETVT MAV_2370|M.avium_104 GDTPYPAAV--GRGDRGP--VWVFSGQGSQWAAMGADLLATEPVFAATVA Mb2956|M.bovis_AF2122/97 GQHAPGVVN-PAEGSPGPGTVFVYSGRGSQWAGMGRQLLADEPAFAAAVA Rv2931|M.tuberculosis_H37Rv GQHAPGVVN-PADGSPGPGTVFVYSGRGSQWAGMGRQLLADEPAFAAAVA MLBr_02357|M.leprae_Br4923 GKQAPGVVG-QQDGTPGSGTVFVYSGRGSQWAGMGRQLLADEPAFTAAVA MMAR_1776|M.marinum_M NQHAPGVVN-PADAPPEPGTVFVYSGRGSQWAGMGRQLLADEPVFAAAVA MUL_2019|M.ulcerans_Agy99 NQHAPGVVN-PADAPPEPGTVFVYSGRGSQWAGMGRQLLADEPAFAAAVA Mflv_3395|M.gilvum_PYR-GCK GHTAPGVVP-PHQGSCRPGKVFVYSGQGAQWTGMGRRLLADEPAFAAAVA Mvan_3128|M.vanbaalenii_PYR-1 GQTAPGVVG-APTGARKRGTVFVYSGQGSQWPGMARQLLADEPAFANALA TH_2454|M.thermoresistible__bu DTRHPAVVAGSVLPAAEAGAVWVFSGHGSHWPGMGRELLEHEPVFAAVID MSMEG_6767|M.smegmatis_MC2_155 GGQIS------AGRAGEARLAFVCTGMGPQWWQMCRGLLDVFPVFTDSIH . .:: :* *.:: * *: *.*: : MAB_0939|M.abscessus_ATCC_1997 RCAEAVKDIVTRPLLEVMFATDRETGGKAGEALRHTSFAQPALFAVEMGL MAV_2370|M.avium_104 QAEPLIARESGFSVAEAMSAPQTVTGQDR---------VQPTLFTMQVAL Mb2956|M.bovis_AF2122/97 ELEPVFVEQAGFSLHDVLANGEELVGIEQ---------IQLGLIGMQLAL Rv2931|M.tuberculosis_H37Rv ELEPVFVEQAGFSLHDVLANGEELVGIEQ---------IQLGLIGMQLAL MLBr_02357|M.leprae_Br4923 ELEPVFVVHAGFSLHDVLANGKELVGIEQ---------IQLGLIGMQLTL MMAR_1776|M.marinum_M ELEPVFLAEAGFSLHDVLANGTELVGIEQ---------IQLGLIGMQLTL MUL_2019|M.ulcerans_Agy99 ELEPVFLAEAGFSLHDVLANGTELVGIEQ---------IQLGLIGMQLTL Mflv_3395|M.gilvum_PYR-GCK ELEPVFVEQVGFSLQQILAGGETVTGIDR---------IQPVLVGMQLAL Mvan_3128|M.vanbaalenii_PYR-1 EIEPVFVEQVGFSLRDVIAGGETVSGDAQ---------VQPVLMGLQLAL TH_2454|M.thermoresistible__bu EIEPVFRAELGFSPRQALQSGE-LGGTDR---------VQALTFAVQAGL MSMEG_6767|M.smegmatis_MC2_155 RTDRELSRYADWSLLEELTRDEASSRMGET------EFAQPANFAIQVAL . . . : : * . :: * MAB_0939|M.abscessus_ATCC_1997 ARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSIEDGARLIAERGRLFGGL MAV_2370|M.avium_104 AATMKAHGVRPGAVIGHSLGEAAAAVVAGALSLEDGARVICRRSRLMSRV Mb2956|M.bovis_AF2122/97 TELWCSYGVQPDLVIGHSMGEVAAAVVAGALTPAEGLRVTATRSRLMAPL Rv2931|M.tuberculosis_H37Rv TELWCSYGVRPDLVIGHSMGEVAAAVVAGALTPAEGLRVTATRSRLMAPL MLBr_02357|M.leprae_Br4923 TELWRSYGVQPDLVIGHSLGEVAAAVVAGALTAAEGLRVTATRSRLMAPL MMAR_1776|M.marinum_M TELWRSYGIQPDLVIGHSMGEVAAAVVAGALTPAEGLRVTAVRSRLMAPL MUL_2019|M.ulcerans_Agy99 TELWRSYGIQPDLVIGHSMGEVAAAVVAGALTPAEGLRVTAVRSRLMAPL Mflv_3395|M.gilvum_PYR-GCK TELWRAYGVHPDAVIGHSMGEVAASVVAGALSVADGLKVIATRSKLMSRL Mvan_3128|M.vanbaalenii_PYR-1 TELWRSYDVHPDAVIGHSMGEVTAAVVAGALSLADGLKVIAARSSIMSRL TH_2454|M.thermoresistible__bu AAVLRDRGVKPAAVIGHSVGEVAACVAAGVFDLARGAAVACYRARGFRSV MSMEG_6767|M.smegmatis_MC2_155 AEQLAHFGITPDAVIGHSAGEVAAHHIAGLLTFEQAVHVIYHRSRLQQRT : .: * *:*** *: :* ** : . : *. MAB_0939|M.abscessus_ATCC_1997 PAGGR--MVAVFSDAKHVEQIAGEFP------RVSVGAYNGP-NTVLSGP MAV_2370|M.avium_104 AGTGATASVELPAQQVLSELTARGIS------DVVVAVVASPQSTVIAGA Mb2956|M.bovis_AF2122/97 SGQGG--MALLELDAPTTEALIADFP------QVTLGIYNSPRQTVIAGP Rv2931|M.tuberculosis_H37Rv SGQGG--MALLELDAPTTEALIADFP------QVTLGIYNSPRQTVIAGP MLBr_02357|M.leprae_Br4923 SGQGG--MALLELDAVETEALIVDYS------QVTLAIYNSPRQTVIAGP MMAR_1776|M.marinum_M SGQGG--MALLELDASQTEALIADYP------QVTLGIYNSPRQTVISGP MUL_2019|M.ulcerans_Agy99 SGQGG--MALLGLDASQTEALIADYP------QVTLGIYNSPRQTVISGP Mflv_3395|M.gilvum_PYR-GCK SGQGA--MALIELDPDAATALIADYP------DVTLAVYASPRQTVIAGP Mvan_3128|M.vanbaalenii_PYR-1 AGQGA--VALVELDPEAAAAFIADYP------SVEVAGFVSPRQTVVAGL TH_2454|M.thermoresistible__bu AGKGA--MALVGLPFEDARQRLGERT------DVVAAISASPLSTVISGT MSMEG_6767|M.smegmatis_MC2_155 TGQGR--MLAVGLDAETLMQILDEKILDQFGRRVSVAAINSPSAVTVAGD .. * : * . .* ..::* MAB_0939|M.abscessus_ATCC_1997 GEDLEQAVARFQEEGIRCTWLETSHAFHSELLDPILDEFESYAAQVQFAA MAV_2370|M.avium_104 APTVRDLVTAWQERGVMAREVPTDVAFHSPQVDPIMDDLTDALAEISPRP Mb2956|M.bovis_AF2122/97 TEQIDELITRVRARDRFASRVNIEVAPHNPAMDALQPAMRSELADLTPRT Rv2931|M.tuberculosis_H37Rv TEQIDELIARVRAQNRFASRVNIEVAPHNPAMDALQPAMRSELADLTPRT MLBr_02357|M.leprae_Br4923 TEQIDELIDRVRAQNRFASRVNIEVAPHNPAMDALQPQMRSELADVAPRT MMAR_1776|M.marinum_M TDQIDELITVVRARDRFATRVNIEVAPHNPAMDALQPQMRSELADLAPRT MUL_2019|M.ulcerans_Agy99 TDQIDELITVVRARDRFATRVNIEVAPHNPAMDALQPQMRSELADLAPRT Mflv_3395|M.gilvum_PYR-GCK PDQVDAVIAAVSAQDRLARRIEVDVASHHPTIDPILPELREALSGLRPVS Mvan_3128|M.vanbaalenii_PYR-1 PEQVDAVIAAVTAQEKFARRVNMEVASHTALMDPVLPDLREALAGVTPRT TH_2454|M.thermoresistible__bu VDAVGEVSAAWAEQGVMVRKVNTDVAFHSPAMDALTAELARLTSTLTPKP MSMEG_6767|M.smegmatis_MC2_155 ADVLEDIARHLDEAQIFNRYLAVKVPYHTHYMETIKDDLHTAFASLSSKA : : . . * ::.: : : : . MAB_0939|M.abscessus_ATCC_1997 PTLPLVCNRTGAVLTAQ---TPIDGQYWRRHSRQPVQFAESVRTVAALG- MAV_2370|M.avium_104 PEVPYYS-ATLFDPREQ---PVCDARYWANNMRRMVRFATAVQAALEDG- Mb2956|M.bovis_AF2122/97 PTIGIISTTYADLHTQ----PVFDAEHWATNMRNPVHFQQAIASAGSGAD Rv2931|M.tuberculosis_H37Rv PTIGIISTTYADLHTQ----PVFDAEHWATNMRNPVRFQQAIASAGSGAD MLBr_02357|M.leprae_Br4923 PTIPILSTTYADLGSC----PVFDAQHWATNMRNPVHFQQAIMTAGT--- MMAR_1776|M.marinum_M PTIPIISTTYADLGSARESGPTFDAEHWAINMRNPVHFQQAITAAAT--- MUL_2019|M.ulcerans_Agy99 PTIPIISTTYADLGAARESGPTFDAEHWAINMRNPVHFQQAITAAAT--- Mflv_3395|M.gilvum_PYR-GCK PNIPIVITTREHDGPE----PVFDADYWVDNLRNPVRFEQAVAAAGA--- Mvan_3128|M.vanbaalenii_PYR-1 PNIPFLSTVTEPDG-E----PALDADYWVANVRQPVKFSQAVTAAAQ--- TH_2454|M.thermoresistible__bu AAVPLYSTALADPRST----AARDEHYWVANLRGRVRFAEAVTAAAED-- MSMEG_6767|M.smegmatis_MC2_155 ATLPLYSTVTGELLDR----YDAGAAYWWQNTRATVLFEPAMRRMLDDG- . : . :* : * * * :: MAB_0939|M.abscessus_ATCC_1997 --CSVLMEIGPQPVLTGAAVQVWPEH--LAPPRAIVSLRKG--------V MAV_2370|M.avium_104 --YRVFAELAPHPLLVRALEQTARSR--EIPMAALAGMRRG--------Q Mb2956|M.bovis_AF2122/97 GAYHTFIEISAHPLLTQAIIDTLHSAQPGARYTSLGTLQRD--------T Rv2931|M.tuberculosis_H37Rv GAYHTFIEISAHPLLTQAIIDTLHSAQPGARYTSLGTLQRD--------T MLBr_02357|M.leprae_Br4923 -DHRTFIEISAHPLLTQAITDTLH----GTRCISIGTLQRD--------A MMAR_1776|M.marinum_M -DKHNFIEISAHPLLTQAILETLHTVQPGSKYTSLGTLQRD--------S MUL_2019|M.ulcerans_Agy99 -DKHNFIEISAHPLLTQAILETLHTVQPGSKYTSLGTLQRD--------S Mflv_3395|M.gilvum_PYR-GCK -EIGTFIEVSPHPLLTYGISDTLG----TSHHHSVPTLLRETGSEGDEAS Mvan_3128|M.vanbaalenii_PYR-1 -EIGTFIEVSANPILTYAINDTLS----SASHVSLGTLARD--------A TH_2454|M.thermoresistible__bu -GHRLFLEVSAHPVVCHSMAETLALA-EVGEHAVLPVLRRE--------Q MSMEG_6767|M.smegmatis_MC2_155 --YTHFVELGPHPVLAASILESAG----TQRVSVDASQRRG--------Q : *:..:*:: . : : MAB_0939|M.abscessus_ATCC_1997 EDRRQIADALASAYVSGHRPNFAALQRHP-RRTVELPTYPFQRRRFWPKS MAV_2370|M.avium_104 ALPHGLRGFVADLHNAGAAVDFSVLYPTG--RLVDAPLPTWTHRRLWLTD Mb2956|M.bovis_AF2122/97 DDVVTFRTNLNKAHTIHPPHTPHPPE-----PHPPIPTTPWQHTRHWITT Rv2931|M.tuberculosis_H37Rv DDVVTFRTNLNKAHTIHPPHTPHPPE-----PHPPIPTTPWQHTRHWITT MLBr_02357|M.leprae_Br4923 DDTVTFHTNLNNVHTVHPPHTPHPAE-----PHVTIPSTPWQHTRHWIPR MMAR_1776|M.marinum_M DDTIVFRTNLNTVRTA-PPQTPHPPE-----PHPQIPTTPWHHTHHWIDT MUL_2019|M.ulcerans_Agy99 DDTIVFRTNLDTVRTA-PPQTPHPPE-----PHPQIPTTPWHHTHHWIDT Mflv_3395|M.gilvum_PYR-GCK DETLSFHTNLNSTFTTKPPVSDHGPE-----PHPVLPATPWHHTRHWVAH Mvan_3128|M.vanbaalenii_PYR-1 DDTLTFHTALNATFTGHPPVTPHHGE-----PHIQLPTTPWHHTHHWAIR TH_2454|M.thermoresistible__bu PELPAVAAVVGALYCHGAPVRPAFPPGTR--WATGLPGTQWQHRRFWRTP MSMEG_6767|M.smegmatis_MC2_155 DDARTLLNCVGALHSRGHEVAWDMVQPRAGAHPVKLPSYPWQTKRFWNDT . : * : : * MAB_0939|M.abscessus_ATCC_1997 --SGTAIEGGGGLPSGILGRG-----EDLASGDSVYISRLSVRSQPWLSD MAV_2370|M.avium_104 --GGLESPTHGGCTVAVHPLLGPHVHLQEEPERHLWQADVGTAAQPWLAD Mb2956|M.bovis_AF2122/97 -KYPAGSVGSAPRAGTLLGQHTTVATVSASPPSHLWQARLAPDAKPYQGG Rv2931|M.tuberculosis_H37Rv -KYPAGSVGSAPRAGTLLGQHTTVATVSASPPSHLWQARLAPDAKPYQGG MLBr_02357|M.leprae_Br4923 -KRSVNSIGLAPQVGTLLGQHT---AVSGILPIHLWQARLAPQAKPYRGW MMAR_1776|M.marinum_M -PAVASRSASTPDKD----------AAGSSEPSVSGDSDDAVDSCHYR-- MUL_2019|M.ulcerans_Agy99 -PAVASRSASTPDKD----------AAGSSEPSVSGDSDDAVDSCHYR-- Mflv_3395|M.gilvum_PYR-GCK -KKVDRRGPSAPRPGTLLGDLT---SVATSPPTHLWQARLVRDAKPYPGF Mvan_3128|M.vanbaalenii_PYR-1 -KHTAS-GATAPRPGTVLGSHT---AVAGTQPGHLWQARLAPQAKPYPQP TH_2454|M.thermoresistible__bu GTPPGGVGVHDVDSHTLLGGR---IDVAGAVPARVWQTRLDLSTRPYPGD MSMEG_6767|M.smegmatis_MC2_155 ---------HEAEEALFYRPVHPLLGQPVRAVHPTWEAEFSTLTVPFLAD : : : MAB_0939|M.abscessus_ATCC_1997 HVIYGTVVVPGATYAAMALAAVG----TPARAKDVFFYEPIILPEKSSRE MAV_2370|M.avium_104 HQIRNVVVLPGAAYCEMALAAARSVLGATAEVRDIRFEQALLLDEQTTVD Mb2956|M.bovis_AF2122/97 HRFHQVEVVPASVVLHTILSAATEL--GYSALSEVRFEQPIFADRPRLIQ Rv2931|M.tuberculosis_H37Rv HRFHQVEVVPASVVLHTILSAATEL--GYSALSEVRFEQPIFADRPRLIQ MLBr_02357|M.leprae_Br4923 HRVHGVEVVPASIVLRTILCAAAEL--GYSTLFEIRFEQPIFANLPRLIQ MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK HRIQGVEVVPMSVLLRTLAAAAAES--GASALADIRFDRPVVVDQPQVIQ Mvan_3128|M.vanbaalenii_PYR-1 HKFAGVEIVPLSVLLQTLSLAAAES--GARAVADVRFDFPITVDAPRVVQ TH_2454|M.thermoresistible__bu HPVQGTEIVPAAVLLNTFLTAAG------SDIADVRLRTPVAPARTRDVQ MSMEG_6767|M.smegmatis_MC2_155 HQVQGSVVVPGAVYVEMALAAGRETYGSDLSVDNLVLHRAVILDDTCDPV MAB_0939|M.abscessus_ATCC_1997 VQLTLHPLEDGSGSKFQVHSRPYGE-----------------------RD MAV_2370|M.avium_104 ASASVSSP---GVLHFTVQSHQGGE-----------------------QA Mb2956|M.bovis_AF2122/97 VVADNRAISLAS---SPAAGTPSDR------------------------- Rv2931|M.tuberculosis_H37Rv VVADNRAISLAS---SPAAGTPSDR------------------------- MLBr_02357|M.leprae_Br4923 VVVDNQLISLAS---SPATETPQHR------------------------- MMAR_1776|M.marinum_M VGWPTKPLADAK---ASTETASGTR------------------------- MUL_2019|M.ulcerans_Agy99 VGWPTKPLADAK---ASTETASGTR------------------------- Mflv_3395|M.gilvum_PYR-GCK VVAHGDTITMAS---APHADAPANR------------------------- Mvan_3128|M.vanbaalenii_PYR-1 VVSDGETITVSSSTAAAGSDDSAQR------------------------- TH_2454|M.thermoresistible__bu VVLQDRALALASRIVGEDTTARATAGRDTTDRDTTACDTTDRDTTACDDP MSMEG_6767|M.smegmatis_MC2_155 IRTTVDQDDGSVEFAALIATADTDLK------------------------ MAB_0939|M.abscessus_ATCC_1997 VDWSLNAEGTVVTGIGDDAEPAPEAAEPAEPVDAAIERMERMRPMELFEI MAV_2370|M.avium_104 RHASAVLGAATDEQPAAHDLSALLTAHPHDDDGDEVRRRMDRRGVQYGPA Mb2956|M.bovis_AF2122/97 --WTRHVTAQLSSSPSDSASSLNEHHRANGQPPERAHRDLIPDLAELLAM Rv2931|M.tuberculosis_H37Rv --WTRHVTAQLSSSPSDSASSLNEHHRANGQPPERAHRDLIPDLAELLAM MLBr_02357|M.leprae_Br4923 --WTRHVTAQLSSASARSAVPSDHPDQING--HLEVISDPIPDVASLLAL MMAR_1776|M.marinum_M --WLVFADAELGAELGLAAG------------------------------ MUL_2019|M.ulcerans_Agy99 --WLVFADAELGAELGLAAG------------------------------ Mflv_3395|M.gilvum_PYR-GCK --WVRHATARVAQPRPADTGAVDVTAATD---------YDRSTVEELQSR Mvan_3128|M.vanbaalenii_PYR-1 --WIRHLTARVAHRVADSPATAGTAQSSG---------YDPSALAELHNA TH_2454|M.thermoresistible__bu GVWLTHCTARVADDHVGAEGVLDEEAIRAR----CPQPLPAGHVVDTLAG MSMEG_6767|M.smegmatis_MC2_155 --WVITATAELNTLPRAPRAGDTGGGAVTSTDGDTFYQRTQALGFDYGEA . MAB_0939|M.abscessus_ATCC_1997 FADLELAWGPTWSGSLKSLWLGEGEAIGDVLVGEELAEQLGTEPMHPVLM MAV_2370|M.avium_104 FAGLGAVHSGDETG----------TVLAEVALPRQIRSQQAAYGAHPALL Mb2956|M.bovis_AF2122/97 RGIDGLPFSWTVASWT-----------------QHSSNLTVAIDLPEALP Rv2931|M.tuberculosis_H37Rv RGIDGLPFSWTVASWT-----------------QHSSNLTVAIDLPEALP MLBr_02357|M.leprae_Br4923 CGVDGLPFEWSVKSWAKK--------------TQQSTSRTVEIEFPDTLP MMAR_1776|M.marinum_M ------------------------------------AQTRVDVIDPSALT MUL_2019|M.ulcerans_Agy99 ------------------------------------AQTRVDVIDPSALT Mflv_3395|M.gilvum_PYR-GCK WGVEGQPFPWSIET---------------------CRATSDGVLAEVRWQ Mvan_3128|M.vanbaalenii_PYR-1 WGIDGMAYPWTVAS---------------------HESAPGELRTVIDLT TH_2454|M.thermoresistible__bu LGVAAMGFGWEVLELHR----------------GEGELFARVAAEPDKSA MSMEG_6767|M.smegmatis_MC2_155 FRSVASVTAGRDWAVAQIDIP------------QSISADVDTYRFHPALI MAB_0939|M.abscessus_ATCC_1997 DLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLKEKMPRRFYCRARWH MAV_2370|M.avium_104 DACF-QSVEAHPAVRALGDGALGLVLGIRR----LRAYGAARNAHYCYTR Mb2956|M.bovis_AF2122/97 EGSTGPLLDAAVHLAALSDVADSRLYVPASIEQISLGDVVTGPRSSVTLN Rv2931|M.tuberculosis_H37Rv EGSTGPLLDAAVHLAALSDVADSRLYVPASIEQISLGDVVTGPRSSVTLN MLBr_02357|M.leprae_Br4923 DGAIAPLLDAAILIPALADVTETQFYVPASIKQVWLGDTATGPCGAVTLN MMAR_1776|M.marinum_M EESE--------LLAALAGVEH---------------------------- MUL_2019|M.ulcerans_Agy99 EGSE--------LLAALAGVEH---------------------------- Mflv_3395|M.gilvum_PYR-GCK DGSAVALLDAAVQVARLADINDDRLLVPAAVESLTATGELLASSGTVTVR Mvan_3128|M.vanbaalenii_PYR-1 PGSLVGLLDAAVNLGRLVDSSSPGLMVPSAAESVRFGDDATGTGGVITAR TH_2454|M.thermoresistible__bu PATWAGLIDAATSTASTIFDGPPRLRMPARIERVHVRDKPP----AIALL MSMEG_6767|M.smegmatis_MC2_155 DGAFQTLFG-----APFSGQEENTDPYLPTRIRHCAVYGPPAEHMTVRAR MAB_0939|M.abscessus_ATCC_1997 ESPLDSETQVFDLDYLDRDGRHLGGIREFTVKRAPREA-----------L MAV_2370|M.avium_104 VTKADTSGVEADIDVLDEHGAVLLAVQGLRVGTSASES-----------G Mb2956|M.bovis_AF2122/97 RTAHDDDGITVDVTVAAHGEVPSLSMRSLRYRALDFGLDVGRAQPPASTG Rv2931|M.tuberculosis_H37Rv RTAHDDDGITVDVTVAAHGEVPSLSMRSLRYRALDFGLDVGRAQPPASTG MLBr_02357|M.leprae_Br4923 RTACDDDGITVDVTVADGSGVPLALMRSLRYRALDLDNAQQDYSTVFVES MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK RRPGTGEDLVLDVAVTVPDDSTRVDIVGLRYVDVQAG------------P Mvan_3128|M.vanbaalenii_PYR-1 SRGRDGDDLLVDISIGGAGGAEYAHITGLRYTPVEIGT-----------V TH_2454|M.thermoresistible__bu HVRRRPEGTVTDVTIAEESGAVSVTLTGMGFEELENP------------G MSMEG_6767|M.smegmatis_MC2_155 VLSATHDAVECDITITDPSGGVLAAFDGFTVQSLSASS------------ MAB_0939|M.abscessus_ATCC_1997 LRGLGGDATRLLYTLGWHEVAVPPVAGEG----EESAASIGTWLIAGFDE MAV_2370|M.avium_104 TRDRVLTERLLNIEWRQRELPEPEHADAASWLLIGTTATADVLASTLADT Mb2956|M.bovis_AF2122/97 PVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAIIGDDGAALC Rv2931|M.tuberculosis_H37Rv PVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAIIGDDGAALC MLBr_02357|M.leprae_Br4923 HVDALTDARNFVHAIDWQPRTDLDCSN---TPVASSGSVAVIGDARAGFG MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK AEAAPADPRSVAHEIAWRPWTAPSETAPAGASLAVVGS--------GTTA Mvan_3128|M.vanbaalenii_PYR-1 TTSAAADPQRVAHRLDWQPWTPAADAGPDTGSVAVIGD--------DDVA TH_2454|M.thermoresistible__bu GGGSSGDLTGMLHHLRWHPVDWPDTDPPAAVVLVG-----------GDAR MSMEG_6767|M.smegmatis_MC2_155 -RMSADHIDKGLFALEWSPVTDTPDTAHGDESTWLILTDNGGVGEAIADG MAB_0939|M.abscessus_ATCC_1997 LAAKVPGCIPLNRETDPELLGEVLVAAKERGVPFSGVVWRAAGPGATEST MAV_2370|M.avium_104 LKNHGAQCTTMAWPQQADHTAHAEQLRNQWRGDGFTGVVVLTGPKNGDND Mb2956|M.bovis_AF2122/97 ETLEGAGYQPAVMSDGVSQARYVVYVADS------------DPAGADETD Rv2931|M.tuberculosis_H37Rv ETLEGAGYQPAVMSDGVSQARYVVYVADS------------DPAGADETD MLBr_02357|M.leprae_Br4923 LLLKEAGYTLAAPADGVSEVRYVVYVADP------------HPATTAETD MMAR_1776|M.marinum_M ----------------------VVYAP---------------PAG-KSLD MUL_2019|M.ulcerans_Agy99 ----------------------VVYAP---------------PAG-KSLD Mflv_3395|M.gilvum_PYR-GCK DALRERLAAAGYTDADEATAQCVLYVP-----------------GPDGDD Mvan_3128|M.vanbaalenii_PYR-1 AAVRGAVAANGHAVAEIPDARFVVYVAD---------------VGDVDSD TH_2454|M.thermoresistible__bu TRAFVTRDLDEARVAHRSYADPAALPPDL------------TAGTVVLVL MSMEG_6767|M.smegmatis_MC2_155 LRLRGHHVHTVAHDPTGEIDWPDMLATHLSGE-------RTGLIDCWPLE MAB_0939|M.abscessus_ATCC_1997 TESAARLEGEIAHLLSAVHTVQNSAQNGVKLPGGLWIVTERAVATESGEP MAV_2370|M.avium_104 QESALLSRDHVQHLVRIARELTDLPGE----PPRLYVVTRNAQTVLPNDV Mb2956|M.bovis_AF2122/97 VDFAVRICTEITGLVRTLAERDADKPAA------LWILTRGVHESVAP-- Rv2931|M.tuberculosis_H37Rv VDFAVRICTEITGLVRTLAERDADKPAA------LWILTRGVHESVAP-- MLBr_02357|M.leprae_Br4923 VDFAVRITAEISDLVRALAKREPGKPVA------LWIVTRGVYESVAS-- MMAR_1776|M.marinum_M VNAAYQLFHQVRRLVTVMTK--ASLTAK------LLLVTRNAQPIAEGDR MUL_2019|M.ulcerans_Agy99 VNAAYQLFHQVRRLVAVMTK--ASLTAK------LLLVTRNAQPIAEGDR Mflv_3395|M.gilvum_PYR-GCK LDATVRLCGEVASLVSRLADRPGTGEPR------LWILTEGVRDADSA-- Mvan_3128|M.vanbaalenii_PYR-1 QDVAVRLTTEVADLVGTLAERDPRNPAT------LWIVTRGVYESATA-- TH_2454|M.thermoresistible__bu PRTAARPAASAQLVLHTLQRLSATNSGAR-----LWVLTRGVHEGTDP-- MSMEG_6767|M.smegmatis_MC2_155 VTDAATDPAGTATVLRIVKALATLDGVTP----RLYLVTANAQPAAGTEL : :: * ::* . MAB_0939|M.abscessus_ATCC_1997 -----VDPVQAALWGFGRTTINEEP-ALRAKLVDGDGSP---------EA MAV_2370|M.avium_104 -----PNLGQAGLRGLVRVIGMEHP-QLGAGQIDVDES----------TD Mb2956|M.bovis_AF2122/97 -----SALRQSFLWGLAGVIAAEHP-ELWGGLVDLAIN-------DDLGE Rv2931|M.tuberculosis_H37Rv -----SALRQSFLWGLAGVIAAEHP-ELWGGLVDLAIN-------DDLGE MLBr_02357|M.leprae_Br4923 -----SALRQSFLWGFGGVIAAEHP-EMWGGLVDLAASALGADRDDILDQ MMAR_1776|M.marinum_M -----ANPAHGVLWGLGRTIALEHP-EIWRGIIDLDES------MPAELA MUL_2019|M.ulcerans_Agy99 -----ANPAHGVLWGLGRTIALEHP-EIWRGIIDLDES------MPAELA Mflv_3395|M.gilvum_PYR-GCK -----QSLPHSSLWGLAGVVGAEQP-QLWGGLVDVASG-------ADLDE Mvan_3128|M.vanbaalenii_PYR-1 -----AALPQSTLWGLAGVVGAEQP-QLWGGLVDLAG--------EDPAG TH_2454|M.thermoresistible__bu --------GHGPLWGLARVAAAEHP-QLWGGLLDIGED------------ MSMEG_6767|M.smegmatis_MC2_155 TGTELTGVEQAAFWGLGRVIGHQELGEYWGGLIDIDHADAP------SST :. : *: . :. :* MAB_0939|M.abscessus_ATCC_1997 VQALARLLVTPVDEPEIAVRQ-----GKLLASRLLPWSRTGHLTVPRGSD MAV_2370|M.avium_104 AQALARQLLAGSEEDETAWRDGAWYTARLCPAPLLPEERHTAVANHECDG Mb2956|M.bovis_AF2122/97 FGPALAELLAKPSKSILVRRDG---------------------------- Rv2931|M.tuberculosis_H37Rv FGPALAELLAKPSKSILVRRDG---------------------------- MLBr_02357|M.leprae_Br4923 FGPTLASLLQTPTRSIVVLRDG---------------------------- MMAR_1776|M.marinum_M APKILGEVTGTDGEDQVVYRCG---------------------------- MUL_2019|M.ulcerans_Agy99 APKILGEVTGTDGEDQVVYRCG---------------------------- Mflv_3395|M.gilvum_PYR-GCK TAKALAGVLPVAAKSILSLRGG---------------------------- Mvan_3128|M.vanbaalenii_PYR-1 SAEALAALLPTPVKSVAILRDG---------------------------- TH_2454|M.thermoresistible__bu -RLPVRALTALTGHGVVVVRDG---------------------------- MSMEG_6767|M.smegmatis_MC2_155 AEQICGHVLGDGAEDQIALRGN---------------------------- : . * MAB_0939|M.abscessus_ATCC_1997 YVLAPTERGAIDNLRITEKEVPAPDEGYVQVRVEAAGLNFRDVLNVLGLY MAV_2370|M.avium_104 MRLQIRTPGDLESLELVACDRIPPGPGQIEVAVSASSINFADVLVAFGRY Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PGDPG---PIGGDFAGIVTQLGEGVTGVEVGQRVYG-SMQGAFGSRFNVP MAV_2370|M.avium_104 PAFEGRLPELGTDFAGVVTAVGPDVTDHKVGDHVGGLSANGCWGTFLTCD Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AQFLAPIPDGISGVEAATIPAAALTVRL-SFDWAQLKPGDKVLIHAASGG MAV_2370|M.avium_104 ARLAVTLPPGLADDQAAAVTTAHATAYYGLHELARIGAGDRVLIHSATGG Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VGLAAIQMAQQFGAEVFATASTFKR-ATLRKLGVKYVYDSRTTDFADQIL MAV_2370|M.avium_104 VGQAAIAIARAAGAEIFATAGSEQRRQLLRDMGIEHVYDSRTVEFADLIR Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAKRDIWTTEQMAQ MAV_2370|M.avium_104 HDTDGYGVDIVLNSVTGAAQRAG-IELLAFGGRFVEIGKRDIYGDTRLGL Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 S--RPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKGEWTPLPAEIYP MAV_2370|M.avium_104 LPFRRNLTFYALDLALMSFSHPDRLRGLLRTVYRLTADGALPMPESTHYP Mb2956|M.bovis_AF2122/97 -------------------------------------------------- Rv2931|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MMAR_1776|M.marinum_M -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3395|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3128|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- MSMEG_6767|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LTEARTAFRRMQQARHIGKIVCQMPNP------------LAPRPDRTYLI MAV_2370|M.avium_104 LADAASAIRVMSAAQHTGKLVLDVPHAGRSRVVVPPAQVRAFRSDGAYIV Mb2956|M.bovis_AF2122/97 -------------VVLAPALAPVRGEP--------ARKSLQCRPDAAYLI Rv2931|M.tuberculosis_H37Rv -------------VVLAPALAPVRGEP--------ARKSLQCRPDAAYLI MLBr_02357|M.leprae_Br4923 -------------VVLAPTLVPIRSEP--------VRKSLQCKSDGAYLI MMAR_1776|M.marinum_M -------------GRHVPRLQ-RRTAP--------AVAPVTLDPNSSQLV MUL_2019|M.ulcerans_Agy99 -------------SRHVPRLQ-RRTAP--------AVAPVTLDPNSSQLV Mflv_3395|M.gilvum_PYR-GCK -------------EFFAPELAALASDP--------VREPLRCRPDAAYLI Mvan_3128|M.vanbaalenii_PYR-1 -------------QLRTSVLAEFTEAP--------ARETLRCRPDAAYLI TH_2454|M.thermoresistible__bu -------------VAHTARLAPAGPGARDS-----AGEGLRCSPGGTYLI MSMEG_6767|M.smegmatis_MC2_155 -------------QILAPRLRPCSGLT--------KPFPTKLTADATYVV : . .. : :: MAB_0939|M.abscessus_ATCC_1997 TGGLGAIGLHTAAYLAQLG----AGDIVLTSRRAP--------------D MAV_2370|M.avium_104 TGGLGGLGLFLAEKMASPGSRAGCGRIVLCSRALP--------------N Mb2956|M.bovis_AF2122/97 TGGLGALGLLMADWLADRG----AHRLVLTGRTPLPPRRDWQLDTLDTEL Rv2931|M.tuberculosis_H37Rv TGGLGALGLLMADWLADRG----AHRLVLTGRTPLPPRRDWQLDTLDTEL MLBr_02357|M.leprae_Br4923 TGGMGALGLLMADWLADRG----ARRLVLMGRTPLPPRRDWELDTLDAGL MMAR_1776|M.marinum_M IGATGNIGPYLIRQLAQMG----AKTVVAVSRNPG--------------- MUL_2019|M.ulcerans_Agy99 IGATGNIGPYLIRQLAQMG----AKTVVAVSRNPG--------------- Mflv_3395|M.gilvum_PYR-GCK TGGLGALGLVTAEWLADRG----ARRVVLAGRTALPPRRRWDDDDLDKDA Mvan_3128|M.vanbaalenii_PYR-1 TGGMGVLGLLMADWLADRG----ARRVVLAGRTPLPPRRDWDDESIDADT TH_2454|M.thermoresistible__bu TGGTGALGLRLAHRLADLG----ARRLVLVSRSGMPARDSWG----RAGD MSMEG_6767|M.smegmatis_MC2_155 TGGAGALGRVVATYLAERG----ARHITLLGRSPISPRDRWASITEDDAH *. * :* :*. * . :. .* MAB_0939|M.abscessus_ATCC_1997 TDAQRVIGEITERSKTRIHVFTADVGAESEVAGLLERIRAELPPLAGVAH MAV_2370|M.avium_104 PKALATLERIRQMG-ADIVVERGDIAEAGTAQRLLDVATATGLPVRGVLH Mb2956|M.bovis_AF2122/97 RRRIDAIRALEMRGVTVEAVAADVGCREDVQALLAARDRDGAAPIRGIIH Rv2931|M.tuberculosis_H37Rv RRRIDAIRALEMRGVTVEAVAADVGCREDVQALLAARDRDGAAPIRGIIH MLBr_02357|M.leprae_Br4923 RQKIDAICALEMRGVTVEAVAVDVGHHDDVQALLAKRDRDGAAPIRGIIH MMAR_1776|M.marinum_M QRLQELAESLAAEGTNLVIEAADATDEAAMTALFDRFGAD-LPPLEGIYL MUL_2019|M.ulcerans_Agy99 QRLQELAESLAAEGTNLVIEAADATDEAAMTALFDRFGAD-LPPLDGIYL Mflv_3395|M.gilvum_PYR-GCK RDKIAAVRALELRGVAVELAPVDIGSRDAVEALLTRRDEQGAPPIRGVIH Mvan_3128|M.vanbaalenii_PYR-1 RHKIAAIRALELRGVSVDTVALDVGSREALTAVLDKRDGDGAPPIRGVIH TH_2454|M.thermoresistible__bu SDTVAAITALEERGVSVRVAALDIGAPGAAARLR--EVLADLPDVRGVIH MSMEG_6767|M.smegmatis_MC2_155 HATVDAIRAIERLGAHVSTASVDITDSDQVRAWLREHTGSGGRPVRGIVH : . : *: MAB_0939|M.abscessus_ATCC_1997 LAGVLDDALLGQQSVERFRTTLAPKAFGAEYLDRLTKG----DDLDFFIV MAV_2370|M.avium_104 LAAVIEDATLANITDELIERDWAAKVYGAWNLHCALQESGAEQSLDWFCS Mb2956|M.bovis_AF2122/97 AAGITNDQLVTSMTGDAVRQVMWPKIGGSQVLHDAFPP----GSVDFFYL Rv2931|M.tuberculosis_H37Rv AAGITNDQLVTSMTGDAVRQVMWPKIGGSQVLHDAFPP----GSVDFFYL MLBr_02357|M.leprae_Br4923 AAGVTNDQLVTNMTDDPVRQVMWPKIAGCQVLHEAFPP----GSVDFFYL MMAR_1776|M.marinum_M AAFAGGPVLLNEMTDADVRAMFAPKLDAAALLHRLSLK----VPARHFVL MUL_2019|M.ulcerans_Agy99 AAFAGGPVLLNEMTDADVRAMFAPKLDAAALLHRLSLK----VPARHFVL Mflv_3395|M.gilvum_PYR-GCK GAGLTDSQLLTDIDDERLRRTLWPKVAGARVLHELFPT----DSVDFLYL Mvan_3128|M.vanbaalenii_PYR-1 AAGMTEAQLLTEIEADRVHRTVWPKIAGAKVLDELFPP----GSLDFLYL TH_2454|M.thermoresistible__bu AAGVEAGALLTNTTAEDIEATMRPKVDGVLALHEVFPP----GRLDWLVL MSMEG_6767|M.smegmatis_MC2_155 AAGSVRDQLLVNMGEDDFAEVLAPKITGTRVLHNVFED----HDLEFFVM * : . . .* . *. : MAB_0939|M.abscessus_ATCC_1997 SSSVSSLFGSPGQSNYATANALLDGLIAQRRAQGLPATGINFGPWGQGG- MAV_2370|M.avium_104 FSSAAALVGSPGQGAYAAANSWLDAFTRWRRARGLKATAIAWGAWAQIG- Mb2956|M.bovis_AF2122/97 TASAAGIFGIPGQGSYAAANSYLDALARARRQQGCHTMSLDWVAWRGLG- Rv2931|M.tuberculosis_H37Rv TASAAGIFGIPGQGSYAAANSYLDALARARRQQGCHTMSLDWVAWRGLG- MLBr_02357|M.leprae_Br4923 TSSAAGIFGIPGQGSYAAANSYLDALARTRRQQGCHTMSIDWVAWRGLG- MMAR_1776|M.marinum_M FSSISGLIGSRWLAHYTATSGYLDALAYARHALGLPATTVNWGLWKSLAD MUL_2019|M.ulcerans_Agy99 FSSISGLIGSRWLAHYTATSGYLDALAYARHALGLPATTVNWGLWKSLAD Mflv_3395|M.gilvum_PYR-GCK TASAGTVFGVPGQGAYAAGNAYLDGLARARRREGGVTASLDWVAWRGLG- Mvan_3128|M.vanbaalenii_PYR-1 AASAGAVFGIPGQGAYAAGNAYLDALARSRHHRGDNTVSLDWVAWQGLG- TH_2454|M.thermoresistible__bu FSSCGYLGGFPGQGAYACGNAYLDAFARYRRASGDATTSVAWTAWRGLG- MSMEG_6767|M.smegmatis_MC2_155 FGSAGSTIAAPGQGNYAAANAFLDAFAHHRQGLGLPALTIGWGPWSVGM- .* . . . *: .. **.: *: * : : : * MAB_0939|M.abscessus_ATCC_1997 ---MASSEAATANISAQGLIPLDPSAALAALAEVVANGTGQATILKANWQ MAV_2370|M.avium_104 ---RGAALADSADVAIT---PDEGAYAFEALLRHDRACTGYAPITGTPWL Mb2956|M.bovis_AF2122/97 --LAADAQLVSEELARMGSRDITPSEAFTAWEFVDGYDVAQAVVVPMPAP Rv2931|M.tuberculosis_H37Rv --LAADAQLVSEELARMGSRDITPSEAFTAWEFVDGYDVAQAVVVPMPAP MLBr_02357|M.leprae_Br4923 --FAANAQIVSDELQRMGSRDITPSEAFTAWEYVDAYDVAQAVVLPVPRS MMAR_1776|M.marinum_M AEHDASQVSVGSGLLPMQDEVAIGTLPLLMNPAAGVHSVVVEADWPLLAA MUL_2019|M.ulcerans_Agy99 AEHDASQVSVGSGLLPMQDEVAIGTLPLLMNPAAGVHSVVVEADWPLLAA Mflv_3395|M.gilvum_PYR-GCK --FGSDAQVVIDELERQGSRPVTPAEAFAAWEYASRFDVAHVVMAPTLDA Mvan_3128|M.vanbaalenii_PYR-1 --FGSEAQVVVSELERVGSRPVVPAEAFAAWDFVTRFDVAQVVMAPMQSA TH_2454|M.thermoresistible__bu --MGSASDFVAAQLDALGMGTVDVDDAMRALDAAIRDGDPNVVVLPLSPA MSMEG_6767|M.smegmatis_MC2_155 ----VEELGLEKVYAQRGIELITPAVGARIIDRLLSQSVPAVVAMNADWS MAB_0939|M.abscessus_ATCC_1997 RAAKVLGSSRPPILDLVLPSAVGEVTGDSE---LLKQLMEIPVPQRAGFV MAV_2370|M.avium_104 TAFAQRSP-----FAEAFRANGQSATGTSK---LRAELEELPPEEWSTRL Mb2956|M.bovis_AF2122/97 AGADG----------SGA-NAYLLPARNWS---VMAAT------EVRSEL Rv2931|M.tuberculosis_H37Rv AGADG----------SGA-NAYLLPARNWS---VMAAT------EVRSEL MLBr_02357|M.leprae_Br4923 YGSAG----------STAGDSYLVPARNWS---QMEAA------EVRKEL MMAR_1776|M.marinum_M AYRTRGSLHIVDDLLRDFAEASTIPARDWS---HLSAQ------EVRTEF MUL_2019|M.ulcerans_Agy99 AYRTRWSLHIVDDLLRDFAEASTIPARDWS---HLSAQ------EVRTEF Mflv_3395|M.gilvum_PYR-GCK DEDTD-----------QAAESG--PERDWS---QMSAD------DVVSEL Mvan_3128|M.vanbaalenii_PYR-1 EDAAA-----------VTADTHRAPTRDWT---AMAPD------ELLAEL TH_2454|M.thermoresistible__bu AAAVPMFADVAPADPDADAPGGEVPDGLSD---GFPADGFPDDGDLAEWV MSMEG_6767|M.smegmatis_MC2_155 RARQVGFGGLVPKMFGELGTADTVGGQDGVGPSILELLAHTADADRPAVI : . MAB_0939|M.abscessus_ATCC_1997 TEFLQREVQNFLRLAQPPAATSR-FLDLGTDSLMAIELRNRLHSQFGGKF MAV_2370|M.avium_104 RRLISDQVSLILRRNVDPDRP---LPEYGLDSLGGLELLTRIQTETG--I Mb2956|M.bovis_AF2122/97 EQGLRRIIAAELRVPEKELDTDRPFAELGLNSLMAMAIRREAEQFVG--I Rv2931|M.tuberculosis_H37Rv EQGLRRIIAAELRVPEKELDTDRPFAELGLNSLMAMAIRREAEQFVG--I MLBr_02357|M.leprae_Br4923 ESGLRTIIAAELRVAEAELDTDRPFAELGLNSLMAMAIRREAEQFIG--I MMAR_1776|M.marinum_M EAGLRRIVARELRVSESDLETDRPLAELGLNSLMAMAIRREAEMFVG--I MUL_2019|M.ulcerans_Agy99 EAGLRRIVARELRVSESDLETDRPLAELGLNSLMAMAIRREAEMFVG--I Mflv_3395|M.gilvum_PYR-GCK ESGLRTILAVELRIGDDEVDSDRPLAEMGLNSVMAMSIRREVEKLAG--I Mvan_3128|M.vanbaalenii_PYR-1 QDGLRGILATELRLPESDVHTDRPFAEMGLNSVMAMSIRREVERLVG--L TH_2454|M.thermoresistible__bu HRRVIAAVAGELGLAETDVDPRLPLVEIGVDSIMTVALRRQLERQTG--L MSMEG_6767|M.smegmatis_MC2_155 AEQVRRLVAAVFDCAVTDIEPDDMLDDIGLDSMMAMDFRVRINSAFS--I : : : . : : * :*: : : . . . : MAB_0939|M.abscessus_ATCC_1997 TINATAVFDYPTIGGLAEYLVGQLPDADAESAEAPPAVESAEA------- MAV_2370|M.avium_104 RVSPADIAAIGTIRGLADLLRDKLTPAGAAQAERV--------------- Mb2956|M.bovis_AF2122/97 ELSATMLFNHPTVKSLASYLAKRVAPHDVSQDNQISALSSSAG------- Rv2931|M.tuberculosis_H37Rv ELSATMLFNHPTVKSLASYLAKRVAPHDVSQDNQISALSSSAG------- MLBr_02357|M.leprae_Br4923 ELSAIMLFNHPTVALLAAYLTKVVAPQHDSQGDEMAALSASAG------- MMAR_1776|M.marinum_M ELSATMLFNHPTVASLASYLANRVAPQDNSSNDQMAELSASAG------- MUL_2019|M.ulcerans_Agy99 ELSATMLFNHPTVASLASYLANRVAPQDNSSNDQMAELSASAG------- Mflv_3395|M.gilvum_PYR-GCK ELSATMLWNYPTIGALAAYLAEKVAPQAVA----EAAEEDSGD------- Mvan_3128|M.vanbaalenii_PYR-1 ELSATMLFNHPTIESFASYLAQQLAPETGGD---DEVADDSGG------- TH_2454|M.thermoresistible__bu TLPPTLLWEHPTAGAVSDRIVEMLRARG---------------------- MSMEG_6767|M.smegmatis_MC2_155 DLPVLEILRGVSVNSLSARILAELRDIHGVAPVEPDTGETASEPTTTDDD : : : .: : : MAB_0939|M.abscessus_ATCC_1997 ----------ESGAGPAAASDAVSELKE---- MAV_2370|M.avium_104 -------------------------------- Mb2956|M.bovis_AF2122/97 ----------SVLDSLFDRIESAPPEAERSV- Rv2931|M.tuberculosis_H37Rv ----------SVLDSLFDRIESAPPEAERSV- MLBr_02357|M.leprae_Br4923 ----------GVLDSLFDRIESTSTEAEGLV- MMAR_1776|M.marinum_M ----------STLDSLFDRIESSSLLPEGPG- MUL_2019|M.ulcerans_Agy99 ----------STLDSLFDRIESSSLLPEGPG- Mflv_3395|M.gilvum_PYR-GCK ----------SLLDSLFDSVEN---------- Mvan_3128|M.vanbaalenii_PYR-1 ----------SLLDSLFDSVEN---------- TH_2454|M.thermoresistible__bu -------------------------------- MSMEG_6767|M.smegmatis_MC2_155 VERLLQDLSEAEMRQLLAELEASGTEAGGAIS