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M. thermoresistible (build 8) TH_4179 (-)

annotation: short-chain dehydrogenase/reductase SDR
coordinates: 1697395 - 1698312
length: 306

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4179--100% (306)short-chain dehydrogenase/reductase SDR
M. thermoresistible (build 8)TH_3199-3e-5343.42% (304) PUTATIVE retinol dehydrogenase 13
M. thermoresistible (build 8)TH_4166-5e-1330.66% (212) PUTATIVE oxidoreductase, short chain dehydrogenase/reductase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0447c-1e-11768.75% (304) short chain dehydrogenase
M. gilvum PYR-GCKMflv_0151-1e-13073.44% (305) short chain dehydrogenase
M. tuberculosis H37RvRv0439c-1e-11768.75% (304) short chain dehydrogenase
M. leprae Br4923MLBr_00315-1e-11266.23% (302) short chain dehydrogenase
M. abscessus ATCC 19977MAB_0646c-1e-11065.13% (304) short chain dehydrogenase
M. marinum MMMAR_0757-1e-12069.54% (302) dehydrogenase/reductase
M. avium 104MAV_4710-1e-11669.87% (302) short chain dehydrogenase
M. smegmatis MC2 155MSMEG_0863-1e-12872.19% (302) short chain dehydrogenase
M. ulcerans Agy99MUL_1391-1e-11968.87% (302) short chain dehydrogenase
M. vanbaalenii PYR-1Mvan_0753-1e-12973.60% (303) short chain dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0447c|M.bovis_AF2122/97           MTANDNKTRKWSAADVPDQSGRVVVVTGANTGIGYHTAAVFADRGAHVVL
Rv0439c|M.tuberculosis_H37Rv        MTANDNKTRKWSAADVPDQSGRVVVVTGANTGIGYHTAAVFADRGAHVVL
MMAR_0757|M.marinum_M               MSANGKAKSHWSASDIPDQSGRVVVVTGANTGLGYHTAEALAGRGAHVVL
MUL_1391|M.ulcerans_Agy99           MSAKGKAKSHWSASDIPDQSGRVVVVTGANTGLGYHTAEALADRGAHVVL
MAV_4710|M.avium_104                MAPHDKRHRDWSEADVGDQSGRVVVITGANTGIGYETAAVLAHRGAHVVL
MLBr_00315|M.leprae_Br4923          -------MAKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVL
MAB_0646c|M.abscessus_ATCC_199      ---MSRSTTKWSTTDIPDQTGRIAIVTGANTGLGLETAKALAAHGAHVVL
Mflv_0151|M.gilvum_PYR-GCK          ----MTS--KWTAADVPDQSGRVAVVTGANTGIGYETAEVLAGKGARVVI
Mvan_0753|M.vanbaalenii_PYR-1       ----MSS--KWTAADVPDQSGRVAVVTGANSGIGYEAAAVLAGRGARVVV
TH_4179|M.thermoresistible__bu      ----MTG--KWTARDVPDQTGRTAVITGANTGLGFETAKVLAEKGAHVVL
MSMEG_0863|M.smegmatis_MC2_155      ----MSADTKWTEADVPDQSGRVAIVTGSNTGLGYETARALAAKGAHVVI
                                             .*:  *: **:** .::**:*:*:* .:* .:* :**:**:

Mb0447c|M.bovis_AF2122/97           AVRNLEKGNAARARIMAARPGAHVTLQQLDLCSLDSVRAAADALRTAYPR
Rv0439c|M.tuberculosis_H37Rv        AVRNLEKGNAARARIMAARPGAHVTLQQLDLCSLDSVRAAADALRTAYPR
MMAR_0757|M.marinum_M               AVRNPEKGNAAVAQIVAAKPQADVTLQALDLSSLDSVRSAADALRSAYPR
MUL_1391|M.ulcerans_Agy99           AVRNPEKGNAAVAQIVAAKPQADVTLQALDLSSLDSVRSAADALRSAYPR
MAV_4710|M.avium_104                AVRDLEKGNAALSRIVAASPNADVTLQQLDLASLASVRSAAEALRAAYPR
MLBr_00315|M.leprae_Br4923          AVRNLDKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLRSDYDH
MAB_0646c|M.abscessus_ATCC_199      AVRNAEKGKAAAEAITAAHSNADVTLQSLDLSSLESVRRASDELKGRYDK
Mflv_0151|M.gilvum_PYR-GCK          AVRDAGKGQKALDAITRKHPGAAVSLQELDLSSLGSVRRATDALRSAHPR
Mvan_0753|M.vanbaalenii_PYR-1       AVRNLDKGRQAVSRIRQLHPGADVMLQELDLSSLASVRAAADDLRAAHPR
TH_4179|M.thermoresistible__bu      AVRDPDKGRRAADRITAAAPHADVTVRQLDLTSLDNIRRAADDLRAGYPR
MSMEG_0863|M.smegmatis_MC2_155      AVRNLDKGRDAVDRIMASTPKADLKLQKLDVGSLDSVRTAADELKGAYPH
                                    ***:  **. *   *    .   : :: **: ** .:* *:. *:  : :

Mb0447c|M.bovis_AF2122/97           IDVLINNAGVMWTPKQVTKDGFELQFGTNHLGHFALTGLVLDHMLPVPGS
Rv0439c|M.tuberculosis_H37Rv        IDVLINNAGVMWTPKQVTKDGFELQFGTNHLGHFALTGLVLDHMLPVPGS
MMAR_0757|M.marinum_M               IDLLINNAGVMWTPKQVTKDGFEMQFGTNHLGHFALTGLLLDHLLPVPGS
MUL_1391|M.ulcerans_Agy99           IDLLINNAGVMWTPKQVTKDGFEMQFGTNHLGHFALTGLLLDHLLPVPGS
MAV_4710|M.avium_104                IDLLINNAGVMWTPKQVTEDGFELQFGTNHLGHFALTGLLLDHLLGVRDS
MLBr_00315|M.leprae_Br4923          IDLLINNAGVMWTPKSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVGS
MAB_0646c|M.abscessus_ATCC_199      IDLLINNAGVMWTEKSSTADGFELQFGTNHLGHYALTGLLLERLLPVEGS
Mflv_0151|M.gilvum_PYR-GCK          IDLLINNAGVMYPPKQVTRDGFELQFGTNHLGHFAFTGLLLDNLLDVPGS
Mvan_0753|M.vanbaalenii_PYR-1       IDLLINNAGVMYPPKQTTSDGFELQFGTNHLGHFALTGLLLDRLLPVEGS
TH_4179|M.thermoresistible__bu      IDLLINNAGVMYPPRQTTRDGFELQFGTNHLGHFALTGQLLDNILPVDGS
MSMEG_0863|M.smegmatis_MC2_155      IDLLINNAGVMYPPKQTTVDGFELQFGTNHLGPFALTGLLIDHLLPVEGS
                                    **:********:. :. * ****:******** :*:** :::.:* : .*

Mb0447c|M.bovis_AF2122/97           RVVTVSSQGHRIHAAIHFDDLQWERRYNRVAAYGQAKLANLLFTYELQRR
Rv0439c|M.tuberculosis_H37Rv        RVVTVSSQGHRIHAAIHFDDLQWERRYNRVAAYGQAKLANLLFTYELQRR
MMAR_0757|M.marinum_M               RVITVSSLGHRIRAAIHFDDLQWERSYNRVAAYGQSKLANLLFTYELQRR
MUL_1391|M.ulcerans_Agy99           RVITVSSLGHRIRAAIHFDDLQWERSYNRVAAYGQSKLANLLFTYELQRR
MAV_4710|M.avium_104                RVVTVSSLGHRLRAAIHFDDLHWERRYDRVAAYGQSKLANLLFTYELQRR
MLBr_00315|M.leprae_Br4923          RVITVSSLSHRLFADIHFNDLQWECNYNRVAAYGQSKLANLLFTYELQRR
MAB_0646c|M.abscessus_ATCC_199      RVVTVSSIGHRIRADIHFDDLQWERDYDRVAAYGQSKLANLLFTYELQRR
Mflv_0151|M.gilvum_PYR-GCK          RVVTVASLAHKNLADIHFDDLQWERKYNRVAAYGQSKLANLMFTYELQRR
Mvan_0753|M.vanbaalenii_PYR-1       RVVSVASIAHNIQADIHFDDLQWERSYNRVAAYGQSKLANLMFTYTLARR
TH_4179|M.thermoresistible__bu      RVVTVASIAHRNMADIHFDDLQWERGYHRVAAYGQSKLANLMFAYELQRR
MSMEG_0863|M.smegmatis_MC2_155      RVVAVASVAHRIRAKIHFEDLQWERRYNRVEAYGQSKLANLLFAYELQRR
                                    **::*:* .*.  * ***:**:**  *.** ****:*****:*:* * **

Mb0447c|M.bovis_AF2122/97           LG-EAGKSTIAVAAHPGGSNTELTRNLPRLIRPVATVLGPLLFQSPEMGA
Rv0439c|M.tuberculosis_H37Rv        LG-EAGKSTIAVAAHPGGSNTELTRNLPRLIRPVATVLGPLLFQSPEMGA
MMAR_0757|M.marinum_M               LAADSQAATIAVAAHPGGSNTELARNLPRMLVPLANILGPALFQSAQMGA
MUL_1391|M.ulcerans_Agy99           LAADSQAATIAVAAHPGDSNTELARNLPRMLVPLANILGPALFQSAQMGA
MAV_4710|M.avium_104                LAAAPDAKTIAVAAHPGGSNTELARHLPGIFRPVQAVLGPVLFQSPAMGA
MLBr_00315|M.leprae_Br4923          LATR--QTTIAVAAHPGGSRTELTRTLPALIAPIFSVAELFLTQDAATGA
MAB_0646c|M.abscessus_ATCC_199      LAG---TNTVALAAHPGGSNTELARNSPLWVRAVFDVVAPVLVQGADMGA
Mflv_0151|M.gilvum_PYR-GCK          LAARG-APTIAVAAHPGISNTELMRHVPGTSLPGVMKLAGLVTNTPAVGA
Mvan_0753|M.vanbaalenii_PYR-1       LAAKG-APTIAVAAHPGISNTELMRHIPGSQLPGFAWLAGLVTNSPAVGS
TH_4179|M.thermoresistible__bu      LSAKN-APTISVAAHPGVSNTELTRYIPGARLPGVSLLAGLLTNSPAVGA
MSMEG_0863|M.smegmatis_MC2_155      LAAAG-KPTISVAAHPGLSNTELMRHIPGTGLPGYHQIASLFSNSPLMGA
                                    *.      *:::***** *.*** *  *    .        . : .  *:

Mb0447c|M.bovis_AF2122/97           LPTLRAATDPTTQGGQYYGPDGFGEQRGHPKVVQSSAQSHDKDLQRRLWT
Rv0439c|M.tuberculosis_H37Rv        LPTLRAATDPTTQGGQYYGPDGFGEQRGHPKVVQSSAQSHDKDLQRRLWT
MMAR_0757|M.marinum_M               LPTLRAATDPSVAGGQYYGPDGFAEQRGHPKIVQSSAQSHDEDLQRRLWT
MUL_1391|M.ulcerans_Agy99           LPTLRTATDPSAAGGQYYGPDGFAEQRGHPKIVQSSAQSHDEDLQRRLWT
MAV_4710|M.avium_104                LPTLRAATDPAVQGAQYYGPDGFLEQRGRPKLVESSAQSHDEQLQRRLWA
MLBr_00315|M.leprae_Br4923          LPTLRAATDAAVLGGQYFGPDGFAEIRGHPKVVASNGKSHDVDRQLRLWA
MAB_0646c|M.abscessus_ATCC_199      LPTLRAATDPAALGGQYYGPDGFMEQRGNPKVVASSEQSYNLDLQRRLWS
Mflv_0151|M.gilvum_PYR-GCK          LPTVRAATDPGVTGGQYYGPSGFNEMVGHPVLVTSNKKSHDVAVQQRLWT
Mvan_0753|M.vanbaalenii_PYR-1       LATLRAATDPGVRGGQYYGPSGVRELVGHPVLVQSNRKSHDVDVQERLWT
TH_4179|M.thermoresistible__bu      LATLRAATDPEVKGGQYYGPDGFQEIRGHPVLVGSSAKSRDEDIQRRLWT
MSMEG_0863|M.smegmatis_MC2_155      LATLRAATDPGVKGGQYYGPDGFREVRGHPELVKSSSQSRDPELQRRLWA
                                    *.*:*:***. . *.**:**.*. *  *.* :* *. :* :   * ***:

Mb0447c|M.bovis_AF2122/97           VSEELTGVSFGV-
Rv0439c|M.tuberculosis_H37Rv        VSEELTGVSFGV-
MMAR_0757|M.marinum_M               VSEELTGVSFPV-
MUL_1391|M.ulcerans_Agy99           VSEELTGVSFPV-
MAV_4710|M.avium_104                VSEELTGVHFPV-
MLBr_00315|M.leprae_Br4923          VSEELTGVVYPVG
MAB_0646c|M.abscessus_ATCC_199      VSEELTDVVFPVK
Mflv_0151|M.gilvum_PYR-GCK          VSEELTGVKYGV-
Mvan_0753|M.vanbaalenii_PYR-1       VSEELTGVSYDL-
TH_4179|M.thermoresistible__bu      VSEELTGVTFPV-
MSMEG_0863|M.smegmatis_MC2_155      VSEELTGVSYPV-
                                    ******.* : :