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MTSKWTAADVPDQSGRVAVVTGANTGIGYETAEVLAGKGARVVIAVRDAGKGQKALDAITRKHPGAAVSL QELDLSSLGSVRRATDALRSAHPRIDLLINNAGVMYPPKQVTRDGFELQFGTNHLGHFAFTGLLLDNLLD VPGSRVVTVASLAHKNLADIHFDDLQWERKYNRVAAYGQSKLANLMFTYELQRRLAARGAPTIAVAAHPG ISNTELMRHVPGTSLPGVMKLAGLVTNTPAVGALPTVRAATDPGVTGGQYYGPSGFNEMVGHPVLVTSNK KSHDVAVQQRLWTVSEELTGVKYGV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0151 | - | - | 100% (305) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0143 | - | 1e-98 | 61.59% (302) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1940 | - | 6e-56 | 45.21% (303) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0447c | - | 1e-116 | 68.75% (304) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0439c | - | 1e-116 | 68.75% (304) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00315 | - | 1e-107 | 66.01% (303) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0643 | - | 1e-110 | 65.69% (306) | short chain dehydrogenase |
| M. marinum M | MMAR_0757 | - | 1e-115 | 69.41% (304) | dehydrogenase/reductase |
| M. avium 104 | MAV_4710 | - | 1e-112 | 69.21% (302) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0863 | - | 1e-121 | 70.30% (303) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4179 | - | 1e-130 | 73.44% (305) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1391 | - | 1e-114 | 68.42% (304) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0753 | - | 1e-140 | 80.86% (303) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0151|M.gilvum_PYR-GCK MTS------KWTAADVPDQSGRVAVVTGANTGIGYETAEVLAGKGARVVI
Mvan_0753|M.vanbaalenii_PYR-1 MSS------KWTAADVPDQSGRVAVVTGANSGIGYEAAAVLAGRGARVVV
TH_4179|M.thermoresistible__bu MTG------KWTARDVPDQTGRTAVITGANTGLGFETAKVLAEKGAHVVL
MSMEG_0863|M.smegmatis_MC2_155 MSAD----TKWTEADVPDQSGRVAIVTGSNTGLGYETARALAAKGAHVVI
Mb0447c|M.bovis_AF2122/97 MTANDNKTRKWSAADVPDQSGRVVVVTGANTGIGYHTAAVFADRGAHVVL
Rv0439c|M.tuberculosis_H37Rv MTANDNKTRKWSAADVPDQSGRVVVVTGANTGIGYHTAAVFADRGAHVVL
MMAR_0757|M.marinum_M MSANGKAKSHWSASDIPDQSGRVVVVTGANTGLGYHTAEALAGRGAHVVL
MUL_1391|M.ulcerans_Agy99 MSAKGKAKSHWSASDIPDQSGRVVVVTGANTGLGYHTAEALADRGAHVVL
MAV_4710|M.avium_104 MAPHDKRHRDWSEADVGDQSGRVVVITGANTGIGYETAAVLAHRGAHVVL
MLBr_00315|M.leprae_Br4923 -------MAKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVL
MAB_0643|M.abscessus_ATCC_1997 MTV------HWTTADIPDQTGRVAVVTGANTGLGLETARALAAAGAQVVL
.*: *: **:**..::**:*:*:* .:* .:* **:**:
Mflv_0151|M.gilvum_PYR-GCK AVRDAGKGQKALDAITRKHPGAAVSLQELDLSSLGSVRRATDALRSAHPR
Mvan_0753|M.vanbaalenii_PYR-1 AVRNLDKGRQAVSRIRQLHPGADVMLQELDLSSLASVRAAADDLRAAHPR
TH_4179|M.thermoresistible__bu AVRDPDKGRRAADRITAAAPHADVTVRQLDLTSLDNIRRAADDLRAGYPR
MSMEG_0863|M.smegmatis_MC2_155 AVRNLDKGRDAVDRIMASTPKADLKLQKLDVGSLDSVRTAADELKGAYPH
Mb0447c|M.bovis_AF2122/97 AVRNLEKGNAARARIMAARPGAHVTLQQLDLCSLDSVRAAADALRTAYPR
Rv0439c|M.tuberculosis_H37Rv AVRNLEKGNAARARIMAARPGAHVTLQQLDLCSLDSVRAAADALRTAYPR
MMAR_0757|M.marinum_M AVRNPEKGNAAVAQIVAAKPQADVTLQALDLSSLDSVRSAADALRSAYPR
MUL_1391|M.ulcerans_Agy99 AVRNPEKGNAAVAQIVAAKPQADVTLQALDLSSLDSVRSAADALRSAYPR
MAV_4710|M.avium_104 AVRDLEKGNAALSRIVAASPNADVTLQQLDLASLASVRSAAEALRAAYPR
MLBr_00315|M.leprae_Br4923 AVRNLDKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLRSDYDH
MAB_0643|M.abscessus_ATCC_1997 AVRDPDKGAAAADDITKGAAGSNLALQRLDLSSLSDIRSAARQLGADYPR
***: ** * * . : :: **: ** .:* *: * : :
Mflv_0151|M.gilvum_PYR-GCK IDLLINNAGVMYPPKQVTRDGFELQFGTNHLGHFAFTGLLLDNLLDVPGS
Mvan_0753|M.vanbaalenii_PYR-1 IDLLINNAGVMYPPKQTTSDGFELQFGTNHLGHFALTGLLLDRLLPVEGS
TH_4179|M.thermoresistible__bu IDLLINNAGVMYPPRQTTRDGFELQFGTNHLGHFALTGQLLDNILPVDGS
MSMEG_0863|M.smegmatis_MC2_155 IDLLINNAGVMYPPKQTTVDGFELQFGTNHLGPFALTGLLIDHLLPVEGS
Mb0447c|M.bovis_AF2122/97 IDVLINNAGVMWTPKQVTKDGFELQFGTNHLGHFALTGLVLDHMLPVPGS
Rv0439c|M.tuberculosis_H37Rv IDVLINNAGVMWTPKQVTKDGFELQFGTNHLGHFALTGLVLDHMLPVPGS
MMAR_0757|M.marinum_M IDLLINNAGVMWTPKQVTKDGFEMQFGTNHLGHFALTGLLLDHLLPVPGS
MUL_1391|M.ulcerans_Agy99 IDLLINNAGVMWTPKQVTKDGFEMQFGTNHLGHFALTGLLLDHLLPVPGS
MAV_4710|M.avium_104 IDLLINNAGVMWTPKQVTEDGFELQFGTNHLGHFALTGLLLDHLLGVRDS
MLBr_00315|M.leprae_Br4923 IDLLINNAGVMWTPKSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVGS
MAB_0643|M.abscessus_ATCC_1997 IDLLINNAGVMYPPKSLTADGFELQFGTNHLGHFALTGLLLENLTAVPDS
**:********:.*:. * ****:******** **:** :::.: : .*
Mflv_0151|M.gilvum_PYR-GCK RVVTVASLAHKNLADIHFDDLQWERKYNRVAAYGQSKLANLMFTYELQRR
Mvan_0753|M.vanbaalenii_PYR-1 RVVSVASIAHNIQADIHFDDLQWERSYNRVAAYGQSKLANLMFTYTLARR
TH_4179|M.thermoresistible__bu RVVTVASIAHRNMADIHFDDLQWERGYHRVAAYGQSKLANLMFAYELQRR
MSMEG_0863|M.smegmatis_MC2_155 RVVAVASVAHRIRAKIHFEDLQWERRYNRVEAYGQSKLANLLFAYELQRR
Mb0447c|M.bovis_AF2122/97 RVVTVSSQGHRIHAAIHFDDLQWERRYNRVAAYGQAKLANLLFTYELQRR
Rv0439c|M.tuberculosis_H37Rv RVVTVSSQGHRIHAAIHFDDLQWERRYNRVAAYGQAKLANLLFTYELQRR
MMAR_0757|M.marinum_M RVITVSSLGHRIRAAIHFDDLQWERSYNRVAAYGQSKLANLLFTYELQRR
MUL_1391|M.ulcerans_Agy99 RVITVSSLGHRIRAAIHFDDLQWERSYNRVAAYGQSKLANLLFTYELQRR
MAV_4710|M.avium_104 RVVTVSSLGHRLRAAIHFDDLHWERRYDRVAAYGQSKLANLLFTYELQRR
MLBr_00315|M.leprae_Br4923 RVITVSSLSHRLFADIHFNDLQWECNYNRVAAYGQSKLANLLFTYELQRR
MAB_0643|M.abscessus_ATCC_1997 RVVIVSSNGHKFRAAIHFDDLQWERGYSRVGAYAQSKLANLLFTYELQRR
**: *:* .*. * ***:**:** * ** **.*:*****:*:* * **
Mflv_0151|M.gilvum_PYR-GCK LA-ARGAPTIAVAAHPGISNTELMRHVPGTSLPGVMKLAGLVTNTPAVGA
Mvan_0753|M.vanbaalenii_PYR-1 LA-AKGAPTIAVAAHPGISNTELMRHIPGSQLPGFAWLAGLVTNSPAVGS
TH_4179|M.thermoresistible__bu LS-AKNAPTISVAAHPGVSNTELTRYIPGARLPGVSLLAGLLTNSPAVGA
MSMEG_0863|M.smegmatis_MC2_155 LA-AAGKPTISVAAHPGLSNTELMRHIPGTGLPGYHQIASLFSNSPLMGA
Mb0447c|M.bovis_AF2122/97 LG-EAGKSTIAVAAHPGGSNTELTRNLPRLIRPVATVLGPLLFQSPEMGA
Rv0439c|M.tuberculosis_H37Rv LG-EAGKSTIAVAAHPGGSNTELTRNLPRLIRPVATVLGPLLFQSPEMGA
MMAR_0757|M.marinum_M LAADSQAATIAVAAHPGGSNTELARNLPRMLVPLANILGPALFQSAQMGA
MUL_1391|M.ulcerans_Agy99 LAADSQAATIAVAAHPGDSNTELARNLPRMLVPLANILGPALFQSAQMGA
MAV_4710|M.avium_104 LAAAPDAKTIAVAAHPGGSNTELARHLPGIFRPVQAVLGPVLFQSPAMGA
MLBr_00315|M.leprae_Br4923 LA--TRQTTIAVAAHPGGSRTELTRTLPALIAPIFSVAELFLTQDAATGA
MAB_0643|M.abscessus_ATCC_1997 LQ-AAGAETVALAAHPGASGTELMRHIT-FGPEALTAAALKIAQSPAMGA
* *:::***** * *** * :. . : . *:
Mflv_0151|M.gilvum_PYR-GCK LPTVRAATDPGVTGGQYYGPSGFNEMVGHPVLVTSNKKSHDVAVQQRLWT
Mvan_0753|M.vanbaalenii_PYR-1 LATLRAATDPGVRGGQYYGPSGVRELVGHPVLVQSNRKSHDVDVQERLWT
TH_4179|M.thermoresistible__bu LATLRAATDPEVKGGQYYGPDGFQEIRGHPVLVGSSAKSRDEDIQRRLWT
MSMEG_0863|M.smegmatis_MC2_155 LATLRAATDPGVKGGQYYGPDGFREVRGHPELVKSSSQSRDPELQRRLWA
Mb0447c|M.bovis_AF2122/97 LPTLRAATDPTTQGGQYYGPDGFGEQRGHPKVVQSSAQSHDKDLQRRLWT
Rv0439c|M.tuberculosis_H37Rv LPTLRAATDPTTQGGQYYGPDGFGEQRGHPKVVQSSAQSHDKDLQRRLWT
MMAR_0757|M.marinum_M LPTLRAATDPSVAGGQYYGPDGFAEQRGHPKIVQSSAQSHDEDLQRRLWT
MUL_1391|M.ulcerans_Agy99 LPTLRTATDPSAAGGQYYGPDGFAEQRGHPKIVQSSAQSHDEDLQRRLWT
MAV_4710|M.avium_104 LPTLRAATDPAVQGAQYYGPDGFLEQRGRPKLVESSAQSHDEQLQRRLWA
MLBr_00315|M.leprae_Br4923 LPTLRAATDAAVLGGQYFGPDGFAEIRGHPKVVASNGKSHDVDRQLRLWA
MAB_0643|M.abscessus_ATCC_1997 LPSLRAATDPAAQGGQYYGPSGFGEFRGYPKVVRSSKQSHDKVLQQRLWS
*.::*:***. . *.**:**.*. * * * :* *. :*:* * ***:
Mflv_0151|M.gilvum_PYR-GCK VSEELTGVKYGV-
Mvan_0753|M.vanbaalenii_PYR-1 VSEELTGVSYDL-
TH_4179|M.thermoresistible__bu VSEELTGVTFPV-
MSMEG_0863|M.smegmatis_MC2_155 VSEELTGVSYPV-
Mb0447c|M.bovis_AF2122/97 VSEELTGVSFGV-
Rv0439c|M.tuberculosis_H37Rv VSEELTGVSFGV-
MMAR_0757|M.marinum_M VSEELTGVSFPV-
MUL_1391|M.ulcerans_Agy99 VSEELTGVSFPV-
MAV_4710|M.avium_104 VSEELTGVHFPV-
MLBr_00315|M.leprae_Br4923 VSEELTGVVYPVG
MAB_0643|M.abscessus_ATCC_1997 VSEELTGVRFPV-
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