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SSKWTAADVPDQSGRVAVVTGANSGIGYEAAAVLAGRGARVVVAVRNLDKGRQAVSRIRQLHPGADVMLQ ELDLSSLASVRAAADDLRAAHPRIDLLINNAGVMYPPKQTTSDGFELQFGTNHLGHFALTGLLLDRLLPV EGSRVVSVASIAHNIQADIHFDDLQWERSYNRVAAYGQSKLANLMFTYTLARRLAAKGAPTIAVAAHPGI SNTELMRHIPGSQLPGFAWLAGLVTNSPAVGSLATLRAATDPGVRGGQYYGPSGVRELVGHPVLVQSNRK SHDVDVQERLWTVSEELTGVSYDL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0753 | - | - | 100% (305) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0762 | - | e-102 | 61.87% (299) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1061 | - | 3e-58 | 45.93% (307) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0447c | - | 1e-115 | 70.00% (300) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0151 | - | 1e-140 | 80.86% (303) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0439c | - | 1e-115 | 70.00% (300) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00315 | - | 1e-108 | 65.78% (301) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0646c | - | 1e-103 | 61.92% (302) | short chain dehydrogenase |
| M. marinum M | MMAR_0757 | - | 1e-114 | 69.54% (302) | dehydrogenase/reductase |
| M. avium 104 | MAV_4710 | - | 1e-112 | 69.33% (300) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0863 | - | 1e-127 | 73.42% (301) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4179 | - | 1e-129 | 73.60% (303) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1391 | - | 1e-113 | 68.54% (302) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0447c|M.bovis_AF2122/97 MTANDNKTRKWSAADVPDQSGRVVVVTGANTGIGYHTAAVFADRGAHVVL
Rv0439c|M.tuberculosis_H37Rv MTANDNKTRKWSAADVPDQSGRVVVVTGANTGIGYHTAAVFADRGAHVVL
MMAR_0757|M.marinum_M MSANGKAKSHWSASDIPDQSGRVVVVTGANTGLGYHTAEALAGRGAHVVL
MUL_1391|M.ulcerans_Agy99 MSAKGKAKSHWSASDIPDQSGRVVVVTGANTGLGYHTAEALADRGAHVVL
MAV_4710|M.avium_104 MAPHDKRHRDWSEADVGDQSGRVVVITGANTGIGYETAAVLAHRGAHVVL
MLBr_00315|M.leprae_Br4923 -------MAKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVL
MAB_0646c|M.abscessus_ATCC_199 ---MSRSTTKWSTTDIPDQTGRIAIVTGANTGLGLETAKALAAHGAHVVL
Mvan_0753|M.vanbaalenii_PYR-1 ----MSS--KWTAADVPDQSGRVAVVTGANSGIGYEAAAVLAGRGARVVV
Mflv_0151|M.gilvum_PYR-GCK ----MTS--KWTAADVPDQSGRVAVVTGANTGIGYETAEVLAGKGARVVI
TH_4179|M.thermoresistible__bu ----MTG--KWTARDVPDQTGRTAVITGANTGLGFETAKVLAEKGAHVVL
MSMEG_0863|M.smegmatis_MC2_155 ----MSADTKWTEADVPDQSGRVAIVTGSNTGLGYETARALAAKGAHVVI
.*: *: **:** .::**:*:*:* .:* .:* :**:**:
Mb0447c|M.bovis_AF2122/97 AVRNLEKGNAARARIMAARPGAHVTLQQLDLCSLDSVRAAADALRTAYPR
Rv0439c|M.tuberculosis_H37Rv AVRNLEKGNAARARIMAARPGAHVTLQQLDLCSLDSVRAAADALRTAYPR
MMAR_0757|M.marinum_M AVRNPEKGNAAVAQIVAAKPQADVTLQALDLSSLDSVRSAADALRSAYPR
MUL_1391|M.ulcerans_Agy99 AVRNPEKGNAAVAQIVAAKPQADVTLQALDLSSLDSVRSAADALRSAYPR
MAV_4710|M.avium_104 AVRDLEKGNAALSRIVAASPNADVTLQQLDLASLASVRSAAEALRAAYPR
MLBr_00315|M.leprae_Br4923 AVRNLDKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLRSDYDH
MAB_0646c|M.abscessus_ATCC_199 AVRNAEKGKAAAEAITAAHSNADVTLQSLDLSSLESVRRASDELKGRYDK
Mvan_0753|M.vanbaalenii_PYR-1 AVRNLDKGRQAVSRIRQLHPGADVMLQELDLSSLASVRAAADDLRAAHPR
Mflv_0151|M.gilvum_PYR-GCK AVRDAGKGQKALDAITRKHPGAAVSLQELDLSSLGSVRRATDALRSAHPR
TH_4179|M.thermoresistible__bu AVRDPDKGRRAADRITAAAPHADVTVRQLDLTSLDNIRRAADDLRAGYPR
MSMEG_0863|M.smegmatis_MC2_155 AVRNLDKGRDAVDRIMASTPKADLKLQKLDVGSLDSVRTAADELKGAYPH
***: **. * * . : :: **: ** .:* *:. *: : :
Mb0447c|M.bovis_AF2122/97 IDVLINNAGVMWTPKQVTKDGFELQFGTNHLGHFALTGLVLDHMLPVPGS
Rv0439c|M.tuberculosis_H37Rv IDVLINNAGVMWTPKQVTKDGFELQFGTNHLGHFALTGLVLDHMLPVPGS
MMAR_0757|M.marinum_M IDLLINNAGVMWTPKQVTKDGFEMQFGTNHLGHFALTGLLLDHLLPVPGS
MUL_1391|M.ulcerans_Agy99 IDLLINNAGVMWTPKQVTKDGFEMQFGTNHLGHFALTGLLLDHLLPVPGS
MAV_4710|M.avium_104 IDLLINNAGVMWTPKQVTEDGFELQFGTNHLGHFALTGLLLDHLLGVRDS
MLBr_00315|M.leprae_Br4923 IDLLINNAGVMWTPKSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVGS
MAB_0646c|M.abscessus_ATCC_199 IDLLINNAGVMWTEKSSTADGFELQFGTNHLGHYALTGLLLERLLPVEGS
Mvan_0753|M.vanbaalenii_PYR-1 IDLLINNAGVMYPPKQTTSDGFELQFGTNHLGHFALTGLLLDRLLPVEGS
Mflv_0151|M.gilvum_PYR-GCK IDLLINNAGVMYPPKQVTRDGFELQFGTNHLGHFAFTGLLLDNLLDVPGS
TH_4179|M.thermoresistible__bu IDLLINNAGVMYPPRQTTRDGFELQFGTNHLGHFALTGQLLDNILPVDGS
MSMEG_0863|M.smegmatis_MC2_155 IDLLINNAGVMYPPKQTTVDGFELQFGTNHLGPFALTGLLIDHLLPVEGS
**:********:. :. * ****:******** :*:** :::.:* : .*
Mb0447c|M.bovis_AF2122/97 RVVTVSSQGHRIHAAIHFDDLQWERRYNRVAAYGQAKLANLLFTYELQRR
Rv0439c|M.tuberculosis_H37Rv RVVTVSSQGHRIHAAIHFDDLQWERRYNRVAAYGQAKLANLLFTYELQRR
MMAR_0757|M.marinum_M RVITVSSLGHRIRAAIHFDDLQWERSYNRVAAYGQSKLANLLFTYELQRR
MUL_1391|M.ulcerans_Agy99 RVITVSSLGHRIRAAIHFDDLQWERSYNRVAAYGQSKLANLLFTYELQRR
MAV_4710|M.avium_104 RVVTVSSLGHRLRAAIHFDDLHWERRYDRVAAYGQSKLANLLFTYELQRR
MLBr_00315|M.leprae_Br4923 RVITVSSLSHRLFADIHFNDLQWECNYNRVAAYGQSKLANLLFTYELQRR
MAB_0646c|M.abscessus_ATCC_199 RVVTVSSIGHRIRADIHFDDLQWERDYDRVAAYGQSKLANLLFTYELQRR
Mvan_0753|M.vanbaalenii_PYR-1 RVVSVASIAHNIQADIHFDDLQWERSYNRVAAYGQSKLANLMFTYTLARR
Mflv_0151|M.gilvum_PYR-GCK RVVTVASLAHKNLADIHFDDLQWERKYNRVAAYGQSKLANLMFTYELQRR
TH_4179|M.thermoresistible__bu RVVTVASIAHRNMADIHFDDLQWERGYHRVAAYGQSKLANLMFAYELQRR
MSMEG_0863|M.smegmatis_MC2_155 RVVAVASVAHRIRAKIHFEDLQWERRYNRVEAYGQSKLANLLFAYELQRR
**::*:* .*. * ***:**:** *.** ****:*****:*:* * **
Mb0447c|M.bovis_AF2122/97 LG-EAGKSTIAVAAHPGGSNTELTRNLPRLIRPVATVLGPLLFQSPEMGA
Rv0439c|M.tuberculosis_H37Rv LG-EAGKSTIAVAAHPGGSNTELTRNLPRLIRPVATVLGPLLFQSPEMGA
MMAR_0757|M.marinum_M LAADSQAATIAVAAHPGGSNTELARNLPRMLVPLANILGPALFQSAQMGA
MUL_1391|M.ulcerans_Agy99 LAADSQAATIAVAAHPGDSNTELARNLPRMLVPLANILGPALFQSAQMGA
MAV_4710|M.avium_104 LAAAPDAKTIAVAAHPGGSNTELARHLPGIFRPVQAVLGPVLFQSPAMGA
MLBr_00315|M.leprae_Br4923 LATR--QTTIAVAAHPGGSRTELTRTLPALIAPIFSVAELFLTQDAATGA
MAB_0646c|M.abscessus_ATCC_199 LAG---TNTVALAAHPGGSNTELARNSPLWVRAVFDVVAPVLVQGADMGA
Mvan_0753|M.vanbaalenii_PYR-1 LAAKG-APTIAVAAHPGISNTELMRHIPGSQLPGFAWLAGLVTNSPAVGS
Mflv_0151|M.gilvum_PYR-GCK LAARG-APTIAVAAHPGISNTELMRHVPGTSLPGVMKLAGLVTNTPAVGA
TH_4179|M.thermoresistible__bu LSAKN-APTISVAAHPGVSNTELTRYIPGARLPGVSLLAGLLTNSPAVGA
MSMEG_0863|M.smegmatis_MC2_155 LAAAG-KPTISVAAHPGLSNTELMRHIPGTGLPGYHQIASLFSNSPLMGA
*. *:::***** *.*** * * . . : . *:
Mb0447c|M.bovis_AF2122/97 LPTLRAATDPTTQGGQYYGPDGFGEQRGHPKVVQSSAQSHDKDLQRRLWT
Rv0439c|M.tuberculosis_H37Rv LPTLRAATDPTTQGGQYYGPDGFGEQRGHPKVVQSSAQSHDKDLQRRLWT
MMAR_0757|M.marinum_M LPTLRAATDPSVAGGQYYGPDGFAEQRGHPKIVQSSAQSHDEDLQRRLWT
MUL_1391|M.ulcerans_Agy99 LPTLRTATDPSAAGGQYYGPDGFAEQRGHPKIVQSSAQSHDEDLQRRLWT
MAV_4710|M.avium_104 LPTLRAATDPAVQGAQYYGPDGFLEQRGRPKLVESSAQSHDEQLQRRLWA
MLBr_00315|M.leprae_Br4923 LPTLRAATDAAVLGGQYFGPDGFAEIRGHPKVVASNGKSHDVDRQLRLWA
MAB_0646c|M.abscessus_ATCC_199 LPTLRAATDPAALGGQYYGPDGFMEQRGNPKVVASSEQSYNLDLQRRLWS
Mvan_0753|M.vanbaalenii_PYR-1 LATLRAATDPGVRGGQYYGPSGVRELVGHPVLVQSNRKSHDVDVQERLWT
Mflv_0151|M.gilvum_PYR-GCK LPTVRAATDPGVTGGQYYGPSGFNEMVGHPVLVTSNKKSHDVAVQQRLWT
TH_4179|M.thermoresistible__bu LATLRAATDPEVKGGQYYGPDGFQEIRGHPVLVGSSAKSRDEDIQRRLWT
MSMEG_0863|M.smegmatis_MC2_155 LATLRAATDPGVKGGQYYGPDGFREVRGHPELVKSSSQSRDPELQRRLWA
*.*:*:***. . *.**:**.*. * *.* :* *. :* : * ***:
Mb0447c|M.bovis_AF2122/97 VSEELTGVSFGV-
Rv0439c|M.tuberculosis_H37Rv VSEELTGVSFGV-
MMAR_0757|M.marinum_M VSEELTGVSFPV-
MUL_1391|M.ulcerans_Agy99 VSEELTGVSFPV-
MAV_4710|M.avium_104 VSEELTGVHFPV-
MLBr_00315|M.leprae_Br4923 VSEELTGVVYPVG
MAB_0646c|M.abscessus_ATCC_199 VSEELTDVVFPVK
Mvan_0753|M.vanbaalenii_PYR-1 VSEELTGVSYDL-
Mflv_0151|M.gilvum_PYR-GCK VSEELTGVKYGV-
TH_4179|M.thermoresistible__bu VSEELTGVTFPV-
MSMEG_0863|M.smegmatis_MC2_155 VSEELTGVSYPV-
******.* : :