For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. abscessus ATCC 19977 MAB_0646c (-)

annotation: short chain dehydrogenase
coordinates: 648123 - 649046
length: 307

SRSTTKWSTTDIPDQTGRIAIVTGANTGLGLETAKALAAHGAHVVLAVRNAEKGKAAAEAITAAHSNADV
TLQSLDLSSLESVRRASDELKGRYDKIDLLINNAGVMWTEKSSTADGFELQFGTNHLGHYALTGLLLERL
LPVEGSRVVTVSSIGHRIRADIHFDDLQWERDYDRVAAYGQSKLANLLFTYELQRRLAGTNTVALAAHPG
GSNTELARNSPLWVRAVFDVVAPVLVQGADMGALPTLRAATDPAALGGQYYGPDGFMEQRGNPKVVASSE
QSYNLDLQRRLWSVSEELTDVVFPVK*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. abscessus ATCC 19977MAB_0646c--100% (307)short chain dehydrogenase
M. abscessus ATCC 19977MAB_0643-e-10868.09% (304) short chain dehydrogenase
M. abscessus ATCC 19977MAB_1144c-5e-6245.95% (309) short-chain dehydrogenase/reductase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0069-1e-12072.52% (302) short chain dehydrogenase
M. gilvum PYR-GCKMflv_0143-1e-10967.22% (302) short chain dehydrogenase
M. tuberculosis H37RvRv0068-1e-12072.19% (302) short chain dehydrogenase
M. leprae Br4923MLBr_00315-1e-11970.10% (301) short chain dehydrogenase
M. marinum MMMAR_0757-1e-12471.66% (307) dehydrogenase/reductase
M. avium 104MAV_4710-1e-11770.86% (302) short chain dehydrogenase
M. smegmatis MC2 155MSMEG_0876-1e-12274.42% (301) short chain dehydrogenase
M. thermoresistible (build 8)TH_4179-1e-11065.13% (304) PUTATIVE short-chain dehydrogenase/reductase SDR
M. ulcerans Agy99MUL_1391-1e-12471.34% (307) short chain dehydrogenase
M. vanbaalenii PYR-1Mvan_0762-1e-11267.88% (302) short chain dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0069|M.bovis_AF2122/97            -------MTKWT---AADIPDQTGRTAVITGANTGLGFETAAALAAHGAH
Rv0068|M.tuberculosis_H37Rv         -------MTKWT---AADIPDQTGRTAVITGANTGLGFETAAALAAHGAH
MSMEG_0876|M.smegmatis_MC2_155      -------MTKWT---TARIPDQTGRVAIVTGANTGLGLETAKALAAKGAH
MLBr_00315|M.leprae_Br4923          -------MAKWT---TADIPDQTGRVAVITGANTGLGYQTALALAEHGAH
MAB_0646c|M.abscessus_ATCC_199      ---MSRSTTKWS---TTDIPDQTGRIAIVTGANTGLGLETAKALAAHGAH
MMAR_0757|M.marinum_M               MSANGKAKSHWS---ASDIPDQSGRVVVVTGANTGLGYHTAEALAGRGAH
MUL_1391|M.ulcerans_Agy99           MSAKGKAKSHWS---ASDIPDQSGRVVVVTGANTGLGYHTAEALADRGAH
MAV_4710|M.avium_104                MAPHDKRHRDWS---EADVGDQSGRVVVITGANTGIGYETAAVLAHRGAH
TH_4179|M.thermoresistible__bu      ------MTGKWT---ARDVPDQTGRTAVITGANTGLGFETAKVLAEKGAH
Mflv_0143|M.gilvum_PYR-GCK          -------MTDWTNWNVADIPDQTGRTAVITGANTGLGFETAKALAEKGAR
Mvan_0762|M.vanbaalenii_PYR-1       -------MTDWT---TADIPDQTGRTAVITGANTGLGFETAKALAAGGAR
                                             .*:      : **:** .::******:* .** .**  **:

Mb0069|M.bovis_AF2122/97            VVLAVRNLDKGKQAAARITEATPGAEVELQELDLTSLASVRAAAAQLKSD
Rv0068|M.tuberculosis_H37Rv         VVLAVRNLDKGKQAAARITEATPGAEVELQELDLTSLASVRAAAAQLKSD
MSMEG_0876|M.smegmatis_MC2_155      VVLAVRNLDKGKAAVDWIARSAPTADLELQQLDLGSLASVRAAADDLKGK
MLBr_00315|M.leprae_Br4923          VVLAVRNLDKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLRSD
MAB_0646c|M.abscessus_ATCC_199      VVLAVRNAEKGKAAAEAITAAHSNADVTLQSLDLSSLESVRRASDELKGR
MMAR_0757|M.marinum_M               VVLAVRNPEKGNAAVAQIVAAKPQADVTLQALDLSSLDSVRSAADALRSA
MUL_1391|M.ulcerans_Agy99           VVLAVRNPEKGNAAVAQIVAAKPQADVTLQALDLSSLDSVRSAADALRSA
MAV_4710|M.avium_104                VVLAVRDLEKGNAALSRIVAASPNADVTLQQLDLASLASVRSAAEALRAA
TH_4179|M.thermoresistible__bu      VVLAVRDPDKGRRAADRITAAAPHADVTVRQLDLTSLDNIRRAADDLRAG
Mflv_0143|M.gilvum_PYR-GCK          VVIAVRNTDKGAQAAARIRG-----DVDVQELDLTSLSSIRTAAEALKAR
Mvan_0762|M.vanbaalenii_PYR-1       VVLAVRDTEKGAQAAAKMAG-----DVDVQQLDLTSLASIRSAADALKSR
                                    **:***: :**  *   :       :: :: *** ** .:* *:  *:. 

Mb0069|M.bovis_AF2122/97            HQRIDLLINNAGVMYTPRQTTADGFEMQFGTNHLGHFALTGLLIDRLLPV
Rv0068|M.tuberculosis_H37Rv         HQRIDLLINNAGVMYTPRQTTADGFEMQFGTNHLGHFALTGLLIDRLLPV
MSMEG_0876|M.smegmatis_MC2_155      FDRIDLLVNNAGVMWPPRQTTADGFELQFGTNHLGHFALTGLLLDRMLTV
MLBr_00315|M.leprae_Br4923          YDHIDLLINNAGVMWTPKSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPI
MAB_0646c|M.abscessus_ATCC_199      YDKIDLLINNAGVMWTEKSSTADGFELQFGTNHLGHYALTGLLLERLLPV
MMAR_0757|M.marinum_M               YPRIDLLINNAGVMWTPKQVTKDGFEMQFGTNHLGHFALTGLLLDHLLPV
MUL_1391|M.ulcerans_Agy99           YPRIDLLINNAGVMWTPKQVTKDGFEMQFGTNHLGHFALTGLLLDHLLPV
MAV_4710|M.avium_104                YPRIDLLINNAGVMWTPKQVTEDGFELQFGTNHLGHFALTGLLLDHLLGV
TH_4179|M.thermoresistible__bu      YPRIDLLINNAGVMYPPRQTTRDGFELQFGTNHLGHFALTGQLLDNILPV
Mflv_0143|M.gilvum_PYR-GCK          FDKIDLLINNAGVMTTPKGTTADGFELQFGTNHLGHFALTGLLFDNILDI
Mvan_0762|M.vanbaalenii_PYR-1       FDHIDLLINNAGVMTTPKGTTADGFELQFGTNHLGHFAFTGLLLDKLLDV
                                    . :****:****** . :  * ****:*********:*:** *::.:* :

Mb0069|M.bovis_AF2122/97            AGSRVVTISSVGHRIRAAIHFDDLQWERRYRRVAAYGQAKLANLLFTYEL
Rv0068|M.tuberculosis_H37Rv         AGSRVVTISSVGHRIRAAIHFDDLQWERRYRRVAAYGQAKLANLLFTYEL
MSMEG_0876|M.smegmatis_MC2_155      PGSRVVTVSSQGHRILAAIHFDDLQWERRYNRVAAYGQSKLANLLFTYEL
MLBr_00315|M.leprae_Br4923          VGSRVITVSSLSHRLFADIHFNDLQWECNYNRVAAYGQSKLANLLFTYEL
MAB_0646c|M.abscessus_ATCC_199      EGSRVVTVSSIGHRIRADIHFDDLQWERDYDRVAAYGQSKLANLLFTYEL
MMAR_0757|M.marinum_M               PGSRVITVSSLGHRIRAAIHFDDLQWERSYNRVAAYGQSKLANLLFTYEL
MUL_1391|M.ulcerans_Agy99           PGSRVITVSSLGHRIRAAIHFDDLQWERSYNRVAAYGQSKLANLLFTYEL
MAV_4710|M.avium_104                RDSRVVTVSSLGHRLRAAIHFDDLHWERRYDRVAAYGQSKLANLLFTYEL
TH_4179|M.thermoresistible__bu      DGSRVVTVASIAHRNMADIHFDDLQWERGYHRVAAYGQSKLANLMFAYEL
Mflv_0143|M.gilvum_PYR-GCK          PGSRIVTVSSNGHKMGGAIHWDDLQWERSYNRMGAYTQSKLANLLFTYEL
Mvan_0762|M.vanbaalenii_PYR-1       DGARIVTVSSNGHKMGGAIHWDDLQWERSYSRMGAYSQSKLANLLFTYEL
                                     .:*::*::* .*:  . **::**:**  * *:.** *:*****:*:***

Mb0069|M.bovis_AF2122/97            QRRLAPG--GTTIAVASHPGVSNTELVRNMPRPLV-AVAAILAP-LMQDA
Rv0068|M.tuberculosis_H37Rv         QRRLAPG--GTTIAVASHPGVSNTEVVRNMPRPLV-AVAAILAP-LMQDA
MSMEG_0876|M.smegmatis_MC2_155      QRRLT-G--HQTTALAAHPGASNTELARHLPG----ALERLVTP-LAQDA
MLBr_00315|M.leprae_Br4923          QRRLATR--QTTIAVAAHPGGSRTELTRTLPALIA-PIFSVAELFLTQDA
MAB_0646c|M.abscessus_ATCC_199      QRRLA-G--TNTVALAAHPGGSNTELARNSPLWVR-AVFDVVAPVLVQGA
MMAR_0757|M.marinum_M               QRRLAADSQAATIAVAAHPGGSNTELARNLPRMLV-PLANILGPALFQSA
MUL_1391|M.ulcerans_Agy99           QRRLAADSQAATIAVAAHPGDSNTELARNLPRMLV-PLANILGPALFQSA
MAV_4710|M.avium_104                QRRLAAAPDAKTIAVAAHPGGSNTELARHLPGIFR-PVQAVLGPVLFQSP
TH_4179|M.thermoresistible__bu      QRRLSAK-NAPTISVAAHPGVSNTELTRYIPGARL-PGVSLLAGLLTNSP
Mflv_0143|M.gilvum_PYR-GCK          QRRLAPR--GKTIAVAAHPGTSTTELARNLPRPVERAFLAAAPVLFAQTA
Mvan_0762|M.vanbaalenii_PYR-1       QRRLAPR--GKTIAVAAHPGTSSTELGRNLPAALQPALNRLAP-LLAQSP
                                    ****:      * ::*:*** * **: *  *     .        : : .

Mb0069|M.bovis_AF2122/97            ELGALPTLRAATDPAVRGGQYFGPDGFGEIRGYPKVVASSAQSHDEQLQR
Rv0068|M.tuberculosis_H37Rv         ELGALPTLRAATDPAVRGGQYFGPDGFGEIRGYPKVVASSAQSHDEQLQR
MSMEG_0876|M.smegmatis_MC2_155      ALGALPTLRAATDPGALGGQYFGPDGIGETRGYPKVVASSAQSHDADLQR
MLBr_00315|M.leprae_Br4923          ATGALPTLRAATDAAVLGGQYFGPDGFAEIRGHPKVVASNGKSHDVDRQL
MAB_0646c|M.abscessus_ATCC_199      DMGALPTLRAATDPAALGGQYYGPDGFMEQRGNPKVVASSEQSYNLDLQR
MMAR_0757|M.marinum_M               QMGALPTLRAATDPSVAGGQYYGPDGFAEQRGHPKIVQSSAQSHDEDLQR
MUL_1391|M.ulcerans_Agy99           QMGALPTLRTATDPSAAGGQYYGPDGFAEQRGHPKIVQSSAQSHDEDLQR
MAV_4710|M.avium_104                AMGALPTLRAATDPAVQGAQYYGPDGFLEQRGRPKLVESSAQSHDEQLQR
TH_4179|M.thermoresistible__bu      AVGALATLRAATDPEVKGGQYYGPDGFQEIRGHPVLVGSSAKSRDEDIQR
Mflv_0143|M.gilvum_PYR-GCK          DRGALPTLRAAADPGVLGGQYYGPDGLGQQRGAPVVVASSAQSYDVDQQR
Mvan_0762|M.vanbaalenii_PYR-1       AAGALPTLRAATDPSVLGGQYYGPDGIGQQRGNPVVVASSNQSYDMALQR
                                      ***.***:*:*. . *.**:****: : ** * :* *. :* :   * 

Mb0069|M.bovis_AF2122/97            RLWAVSEELTGVVYPVG------
Rv0068|M.tuberculosis_H37Rv         RLWAVSEELTGVVYPVG------
MSMEG_0876|M.smegmatis_MC2_155      RLWAVSEELTGVTFPVGEALQQA
MLBr_00315|M.leprae_Br4923          RLWAVSEELTGVVYPVG------
MAB_0646c|M.abscessus_ATCC_199      RLWSVSEELTDVVFPVK------
MMAR_0757|M.marinum_M               RLWTVSEELTGVSFPV-------
MUL_1391|M.ulcerans_Agy99           RLWTVSEELTGVSFPV-------
MAV_4710|M.avium_104                RLWAVSEELTGVHFPV-------
TH_4179|M.thermoresistible__bu      RLWTVSEELTGVTFPV-------
Mflv_0143|M.gilvum_PYR-GCK          RLWEISEELTKVTFPDL------
Mvan_0762|M.vanbaalenii_PYR-1       RLWTVSEELTGVTFPVPVLS---
                                    *** :***** * :*