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M. thermoresistible (build 8) TH_3923 (-)

annotation: putative monooxygenase, FAD-binding
coordinates: 1043141 - 1044907
length: 589

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3923--100% (589)putative monooxygenase, FAD-binding
M. thermoresistible (build 8)TH_2800-1e-6434.84% (597) PUTATIVE putative monooxygenase, FAD-binding
M. thermoresistible (build 8)TH_4641-4e-2727.58% (591) PUTATIVE oxygenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97-----
M. gilvum PYR-GCKMflv_5009-9e-2825.82% (577) monooxygenase, FAD-binding
M. tuberculosis H37RvRv1751-2e-0623.74% (358) hypothetical protein Rv1751
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4357c-3e-6631.61% (598) putative monooxygenase
M. marinum MMMAR_3384-3e-4627.92% (573) hydroxylase
M. avium 104MAV_2189-2e-5231.53% (590) FAD binding domain-containing protein
M. smegmatis MC2 155MSMEG_1499-4e-2525.55% (587) oxygenase
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_4406-1e-8032.83% (594) monooxygenase, FAD-binding

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_5009|M.gilvum_PYR-GCK          ----------------------------------------------MPGA
MSMEG_1499|M.smegmatis_MC2_155      -----------------------------------------------MAA
TH_3923|M.thermoresistible__bu      -----------------------------------------------MAD
Mvan_4406|M.vanbaalenii_PYR-1       --------------------------------MPEFNDGIAETPLPDSAV
MAB_4357c|M.abscessus_ATCC_199      -----------------------------------------------MST
MAV_2189|M.avium_104                ------------------------------------------------MT
MMAR_3384|M.marinum_M               -------------------------------------------MSNATLP
Rv1751|M.tuberculosis_H37Rv         MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
                                                                                      

Mflv_5009|M.gilvum_PYR-GCK          HRSDVVVVGAGPTGLTLACCLRLHGVSVRVLDAAAGPATTSRANFLHARG
MSMEG_1499|M.smegmatis_MC2_155      TDCDVIVVGAGPTGLTLACSLRLHGLSVRVLDRAAGPATTSRANFLHARG
TH_3923|M.thermoresistible__bu      LTVPVLVVGGGGCGLTTSILLSSHGIQHHLVEQHSGTSPLPKAHYLNQRT
Mvan_4406|M.vanbaalenii_PYR-1       IETDVLIVGSGPAGASAALFLSTLGIPNIMITKYRWTADTPRAHITNQRA
MAB_4357c|M.abscessus_ATCC_199      VITPVVIVGAGPTGLATAYVLGRLGVRSIVCDQYDGVNPHPRAHVVNTRS
MAV_2189|M.avium_104                TRVPVLIVGAGVGGLSMSALLTQHGVRSLLVEKRREVFLYPKARNLSFRS
MMAR_3384|M.marinum_M               AESDVLVVGAGPAGMVTAALLERLGMAVRILERFPSRLALPKAHVVGPVT
Rv1751|M.tuberculosis_H37Rv         ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
                                          ::*.*  *   .  *   *:   :           :.       

Mflv_5009|M.gilvum_PYR-GCK          SEVLDRMGA-LGTLPQESLRALRITNYLGDRPLATLEFGDPGMRTAAP--
MSMEG_1499|M.smegmatis_MC2_155      SEVLNRIGA-LGTLPDESLRAMRITNYLGDRPVMTLTFGDPGMRTAAP--
TH_3923|M.thermoresistible__bu      MEVFRQYGL-ADSIYAVGTPPKNMGRTRWVTSLGGDGELDARTLFTLESF
Mvan_4406|M.vanbaalenii_PYR-1       MEIFRDMGI-EDQVLADATRHALVGDTVFCTSIAGEEIGRIHTWGTRP--
MAB_4357c|M.abscessus_ATCC_199      MELLRNWGI-YDEIIADAIDFNRGINVLWKHTVAGEEFGRLDLADVPE--
MAV_2189|M.avium_104                LEILRGMGL-GDEVHAVAEHVS---TVVAKPALNSPEE--RPALDVEG--
MMAR_3384|M.marinum_M               LDICVQAGLDVDRMSADAHPPEWDQFVRFATRLFGEQLGTIAYEYQSP--
Rv1751|M.tuberculosis_H37Rv         MRLLDELGLWERFAALPYSEVRTATLHSNGRAVTYIDFERLHQPYPYV--
                                      :    *                        :                 

Mflv_5009|M.gilvum_PYR-GCK          ----------------PMVVSQAKVEAALRARLADLD-VEPEWGRKVIDV
MSMEG_1499|M.smegmatis_MC2_155      ----------------PMVVSQARVEAALRARLAQLG-VEPEWGRKVAGV
TH_3923|M.thermoresistible__bu      GGGGLENKYAQDSPCLSSNYPQIRLEPLLRDHAERRAPGAIHFNHKLMSF
Mvan_4406|M.vanbaalenii_PYR-1       ---DREADYRLASPCELVDIPQTYLEPILVRNATSRG-TQTRFSTEYVSH
MAB_4357c|M.abscessus_ATCC_199      ---AHLARRLNASPVTIGSCAQDRVQGRLLEAVRSSGMTEVRYRTKVSAV
MAV_2189|M.avium_104                ---IFAGLERFSPEPAAQYCPQSRLEPILLAATRR-GGSDVRYGTELSSI
MMAR_3384|M.marinum_M               ----------EWTARPRINLSQPRFEAIVEGDVRQRPGIEWVCGRWTGAQ
Rv1751|M.tuberculosis_H37Rv         -----------------AMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGL
                                                        .*  .   :                     

Mflv_5009|M.gilvum_PYR-GCK          REDADGVVADLAD-----GARVRGQWLVGCDGTTSVVRRQTGIEFPG---
MSMEG_1499|M.smegmatis_MC2_155      RQAGDRVVADLAD-----GAQVSGQWLVGCDGTSSATREQVGIPFPG---
TH_3923|M.thermoresistible__bu      TLDDEGVEATILDQDNQRTYTVRAQYMVAADGGK-TIGPALGVVMEGPSG
Mvan_4406|M.vanbaalenii_PYR-1       AQDTTGVDVQVRDRLTGNQYTIRAKYLIGADGARSKVAADIGLPFEGAMD
MAB_4357c|M.abscessus_ATCC_199      GAHEDHVDVYLE--KDGHAETLRAEYVVDAEGAAARLRQSIGIDVEGIPE
MAV_2189|M.avium_104                DMDEAGVTAVVRDAESGTAETIRADYLIGADGVHSPLRNLLGITTSGYGA
MMAR_3384|M.marinum_M               VDKGKVVSTATVD---DRQVQFSSRYLIGADGANSAVRESLGISMHTYGQ
Rv1751|M.tuberculosis_H37Rv         LREGGKVTGVRYQG-AEGPGELRAELTVACDGRWSIARHEAGLKAREFP-
                                          *              . .   : .:*         *:       

Mflv_5009|M.gilvum_PYR-GCK          --VRLSERFLLADIHLDWAVDRAGTTGWIHP-----DGVVGAMPMPSTDG
MSMEG_1499|M.smegmatis_MC2_155      --VKLSERFLLADIHLDWAVDRGGTTGWIHP-----DGVVGAMPMPSGDG
TH_3923|M.thermoresistible__bu      IL-DMVSTHFSADLSQYWEDDVLITWLLNPEGAGSWHSGAMAAMGPTWGK
Mvan_4406|M.vanbaalenii_PYR-1       IA-GSMNITFKADIASHVAHRPSVLYWVIQPGAN--VGGIGAGLVRMVRP
MAB_4357c|M.abscessus_ATCC_199      FG-HQINMYFHADLSEWTDQESE-LLFWVL------NTGCPGVFIRLGGN
MAV_2189|M.avium_104                LPIYVVFVYFRAPWRKFIPHLHDGDGVQVK------NADVDGIFLVAEGD
MMAR_3384|M.marinum_M               PS-HQINAHVVADMREQLTDHPAVLYALVDP-----EVAGVAVIHGLGEP
Rv1751|M.tuberculosis_H37Rv         --------VNFDVWWFKLPREGDAEFSFLPR----FSPGKGLGVIPREGY
                                                                                      

Mflv_5009|M.gilvum_PYR-GCK          RDDLWRLFVYDPSLDRKPTDSEILDRISELVPYRTGRRVKIGDAEWLSMF
MSMEG_1499|M.smegmatis_MC2_155      RNDLWRLFVYDPALNRKPSDSEILQRIEQIVPYRTGRAITIGQPEWLSMF
TH_3923|M.thermoresistible__bu      HSEEFVIHFTFRPDDPARFDE---EAIVPRLRELLKLPNLKPKVHKVSHW
Mvan_4406|M.vanbaalenii_PYR-1       WNEWLIVWGYDINDEPPALDE---DEAVNIVRQLLGISDLPVEITGASLW
MAB_4357c|M.abscessus_ATCC_199      RWTFHTGFDPAR-EAVSDYTP---ERCRELIRLAVGAPELEIDMRSVGTW
MAV_2189|M.avium_104                LGMFITTYFPDEGETAEQFTP---QRCRELLTKAIGEP-LDIDVIEVAAW
MMAR_3384|M.marinum_M               GHDNTIEWICGSPYDGENVPE--MDTIVDRVRKVIGSDDIGFEVLKLSPW
Rv1751|M.tuberculosis_H37Rv         FQIAYLGPKGTDAQLRERGIEEFRRDVSELLPEATASVAALASMDEVKHL
                                                                  :           .       

Mflv_5009|M.gilvum_PYR-GCK          TVHRRLADTYRRGRVLIAGDAAHVHAPFGGQGMLTGIGDAENVGFKLALV
MSMEG_1499|M.smegmatis_MC2_155      TVHRRLAQSYRRGRVLIAGDAAHAHAPFGGQGMLTGIGDAENLAFKLALV
TH_3923|M.thermoresistible__bu      ILEGVLADRYQVGRVFLAGDAAHRHPPTTGLGLNTAIQDAHNLVWKLAAV
Mvan_4406|M.vanbaalenii_PYR-1       GNNEMYATHLQQGRVFCAGDAVHRHPPSNGLGSNTSIQDSYNLAWKIAAV
MAB_4357c|M.abscessus_ATCC_199      VLGASTARQYRKGRVFLVGDAAHQFPPTGGLGMNTGLVDADNLGWKLAAV
MAV_2189|M.avium_104                QPYEQVADRFDCGRAFLVGDSAHTMPPFKAGGANTAIQSAHNLAWKLAAV
MMAR_3384|M.marinum_M               VLTARVADQFQAGPCFLIGDAAHRLPPTGGLGMNTAIQDGANLAWKLAAV
Rv1751|M.tuberculosis_H37Rv         NVKVNRLRRWHIDGLLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEP
                                                .  :  **:.*  .*  . *   .: ..      :*  

Mflv_5009|M.gilvum_PYR-GCK          VRGLAADDLLDTYEAERRPLATQVLRGTSAITR-----------------
MSMEG_1499|M.smegmatis_MC2_155      IRGLAADALIDTYEAERRFLATEVLRGTSAITR-----------------
TH_3923|M.thermoresistible__bu      LRGDAGPALLETYESERRPVGMRNVDWAMFTFLNHLTIDAGLGLSPDQPL
Mvan_4406|M.vanbaalenii_PYR-1       LRGQADPALLETYSAERAPIAEQIVKRANKSSREYGQFFEVLGLLDANDE
MAB_4357c|M.abscessus_ATCC_199      LQGWAHTQLLDTYESERRPVALANAESSIANVMKMADAGIGPNTMAVAAK
MAV_2189|M.avium_104                LRGAAGPALLDTYHAERHPVGVFAARQSLT----------GPSMALLRP-
MMAR_3384|M.marinum_M               IHGWAGEALLQSYSTERRPIAIANTLRSLENFEIHIQALAELATAALDG-
Rv1751|M.tuberculosis_H37Rv         LREHRVSSRHLAAVRRRRAFPTAVTQAVQR--------------------
                                    ::         :   .*  .                              

Mflv_5009|M.gilvum_PYR-GCK          -----------------VNVAGNPIVRFLRDRVAPRVFGLPAVQRWT---
MSMEG_1499|M.smegmatis_MC2_155      -----------------VNVASNPVGRFLRDRVATRIFGLPVVQRWT---
TH_3923|M.thermoresistible__bu      EARVQVFRDYFSDTPMGETRRARAFEVVNTQRTEFQAHDLEIGFSYEQGA
Mvan_4406|M.vanbaalenii_PYR-1       QEMAARIEERKAATPRGAAMREALVAAMELKNYEFNAHGVDLGQTYQSAA
MAB_4357c|M.abscessus_ATCC_199      LESDIPA--------VAAAERSRMAAAVPEQRPHFDYLELELGYVYG---
MAV_2189|M.avium_104                -----------------GGKRPQLPADEEAP-----IFALMIGYRYG---
MMAR_3384|M.marinum_M               --------------TLHTMAAERLDNLVQQNSIGFNSPGLQLGYGYG---
Rv1751|M.tuberculosis_H37Rv         -----------------VLHRRLLGPLLQGRDPTPPAALLGLVERLP---
                                                                           :          

Mflv_5009|M.gilvum_PYR-GCK          ------------TYTASQLWVSYRNGPLGGRGSKPRPGDRIDDAPCSRPD
MSMEG_1499|M.smegmatis_MC2_155      ------------TYTASQLWVSYRKGPLGGHGRRPRLGDRIGDRPCTRAD
TH_3923|M.thermoresistible__bu      LVPDG-TQPPPRDPMGAVYHPTTRPGHRLPHVWLERDGRRISTHDLTGAG
Mvan_4406|M.vanbaalenii_PYR-1       VVSEGSTLPIPARDPELFYEMSTVPGSHLPHAWVGDSRTKLALMDLAPY-
MAB_4357c|M.abscessus_ATCC_199      -----------GHNDAVDPITTAVMGGRMPHHWVNLGDRRISTLDLVGV-
MAV_2189|M.avium_104                -----------ANGIELVDELRAQPGTRVPHVWVRDG---VSTLDLVGP-
MMAR_3384|M.marinum_M               --------PNQEVADATSFTPSAAVGRRLPHAQVKTGAVDVVPIIDLVDR
Rv1751|M.tuberculosis_H37Rv         -------------------WLSAVPAYFVG--------------------
                                                             .                        

Mflv_5009|M.gilvum_PYR-GCK          GTATRLHGELGGRWALLLPRGVPAVGAAAVRGPA-------GYLADHVVT
MSMEG_1499|M.smegmatis_MC2_155      GAATRLHSELAGRWALLWPRDAPAPGASLLAR-----------LGDFGVT
TH_3923|M.thermoresistible__bu      ERFALITGPTIGPWAEAAQLAEEKYRVQIVVVAVGNGGEYRDPTGTWARV
Mvan_4406|M.vanbaalenii_PYR-1       TEWTVITGIAGEAWAGAADKVGHELGIPLRTVVIGPGREVTDLYYDWAKL
MAB_4357c|M.abscessus_ATCC_199      -GFVLIAGPEGAEWIDAPKIREMRIPLQVYLVGR-------DLEPIGGAI
MAV_2189|M.avium_104                -EFTVLTGDE--RWCAAAAS-------MSLPAHR-------VYNDQWAAI
MMAR_3384|M.marinum_M               AGFTVFIQGAADPWREASGGSEFPVTIVDLAGAV--------ADQGWLEL
Rv1751|M.tuberculosis_H37Rv         --------------------------------------------------
                                                                                      

Mflv_5009|M.gilvum_PYR-GCK          LHHDRD-DVMLVRPDAHLAWRG---AHDDPTGLDRWLATALHPGGTQ---
MSMEG_1499|M.smegmatis_MC2_155      LRHDGA-EAMLIRPDAHLAWRG---APDDTAGLDHWLAKALGSGAVR---
TH_3923|M.thermoresistible__bu      RGYEDG-GAVLVRPDNHVGWRCPAGIMSPGDELACALSNIVSR-------
Mvan_4406|M.vanbaalenii_PYR-1       REVDED-GALLVRPDKHIAWRSMSMPDQPHAALRSAMAQILGRD------
MAB_4357c|M.abscessus_ATCC_199      PGAEGN-GAVLVRPDGHIAWIGTGLAVDPVEEISLAVETLCGKPLSEIAT
MAV_2189|M.avium_104                TGLAPD-GALLIRPDDFVGWRADELPTDPQTALRQALSLCLGRAR-----
MMAR_3384|M.marinum_M               TGLAHEGAALVVRPDGHIAAKAAGPQSWPGIHSSLRNHLQTGQPLGTEAI
Rv1751|M.tuberculosis_H37Rv         ---------VGVRPEHAPAFARRGPGNRKGP-------------------
                                             : :**:   .                               

Mflv_5009|M.gilvum_PYR-GCK          -
MSMEG_1499|M.smegmatis_MC2_155      -
TH_3923|M.thermoresistible__bu      -
Mvan_4406|M.vanbaalenii_PYR-1       -
MAB_4357c|M.abscessus_ATCC_199      -
MAV_2189|M.avium_104                -
MMAR_3384|M.marinum_M               A
Rv1751|M.tuberculosis_H37Rv         -