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MTTRVPVLIVGAGVGGLSMSALLTQHGVRSLLVEKRREVFLYPKARNLSFRSLEILRGMGLGDEVHAVAE HVSTVVAKPALNSPEERPALDVEGIFAGLERFSPEPAAQYCPQSRLEPILLAATRRGGSDVRYGTELSSI DMDEAGVTAVVRDAESGTAETIRADYLIGADGVHSPLRNLLGITTSGYGALPIYVVFVYFRAPWRKFIPH LHDGDGVQVKNADVDGIFLVAEGDLGMFITTYFPDEGETAEQFTPQRCRELLTKAIGEPLDIDVIEVAAW QPYEQVADRFDCGRAFLVGDSAHTMPPFKAGGANTAIQSAHNLAWKLAAVLRGAAGPALLDTYHAERHPV GVFAARQSLTGPSMALLRPGGKRPQLPADEEAPIFALMIGYRYGANGIELVDELRAQPGTRVPHVWVRDG VSTLDLVGPEFTVLTGDERWCAAAASMSLPAHRVYNDQWAAITGLAPDGALLIRPDDFVGWRADELPTDP QTALRQALSLCLGRAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2189 | - | - | 100% (506) | FAD binding domain-containing protein |
| M. avium 104 | MAV_1804 | mhpA | 3e-30 | 29.97% (367) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. avium 104 | MAV_2736 | - | 1e-28 | 29.28% (526) | hypothetical protein MAV_2736 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 6e-09 | 23.37% (398) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_2401 | mhpA | 2e-28 | 29.59% (365) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. tuberculosis H37Rv | Rv1751 | - | 5e-09 | 23.37% (398) | hypothetical protein Rv1751 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4357c | - | 4e-58 | 32.85% (548) | putative monooxygenase |
| M. marinum M | MMAR_3384 | - | 3e-34 | 29.76% (531) | hydroxylase |
| M. smegmatis MC2 155 | MSMEG_4866 | mhpA | 1e-32 | 30.85% (363) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. thermoresistible (build 8) | TH_2800 | - | 5e-57 | 32.30% (551) | PUTATIVE putative monooxygenase, FAD-binding |
| M. ulcerans Agy99 | MUL_3663 | - | 2e-12 | 24.35% (386) | hypothetical protein MUL_3663 |
| M. vanbaalenii PYR-1 | Mvan_4406 | - | 5e-50 | 29.02% (579) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4357c|M.abscessus_ATCC_199 -----------------------------------------------MST
TH_2800|M.thermoresistible__bu ----------------------------------------------VSGP
MAV_2189|M.avium_104 ------------------------------------------------MT
Mflv_2401|M.gilvum_PYR-GCK ----------------------------------------------MTEQ
MSMEG_4866|M.smegmatis_MC2_155 ---------------------------------------------MMNSP
Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
MUL_3663|M.ulcerans_Agy99 -------------------------------------MPQPS--------
Mvan_4406|M.vanbaalenii_PYR-1 --------------------------------MPEFNDGIAETPLPDSAV
MMAR_3384|M.marinum_M -------------------------------------------MSNATLP
MAB_4357c|M.abscessus_ATCC_199 VITPVVIVGAGPTGLATAYVLGRLGVRSIVCDQYDGVNPHPRAHVVNTRS
TH_2800|M.thermoresistible__bu EQAPVLIVGAGPAGLATAYVLGRNGIPSVVCDQHSGIHPHPRAHVINTRS
MAV_2189|M.avium_104 TRVPVLIVGAGVGGLSMSALLTQHGVRSLLVEKRREVFLYPKARNLSFRS
Mflv_2401|M.gilvum_PYR-GCK TDVDVVIVGAGPAGLTLANILGLEGVRVLVVDERDKLIDYPRGVGLDDES
MSMEG_4866|M.smegmatis_MC2_155 GAVDVVIVGAGPVGLTLANILGGQGVRTLIIEERETLIDYPRGVGLDDES
Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
MUL_3663|M.ulcerans_Agy99 ETTSVLVAGGGPAGMVLGLLLARAGVDVTVMEKHADFLRDSRGDTVHAST
Mvan_4406|M.vanbaalenii_PYR-1 IETDVLIVGSGPAGASAALFLSTLGIPNIMITKYRWTADTPRAHITNQRA
MMAR_3384|M.marinum_M AESDVLVVGAGPAGMVTAALLERLGMAVRILERFPSRLALPKAHVVGPVT
: *.* * . .* *: : . :. :
MAB_4357c|M.abscessus_ATCC_199 MELLRNWGIYDEIIADAIDFNR--GINVLWKHTVAGEEFGRLDLADVPEA
TH_2800|M.thermoresistible__bu MELFRSWGIADAIARDEQAFDAGAGVRIVWKHSVSGEELGCIDLLDAPVE
MAV_2189|M.avium_104 LEILRGMGLGDEVHAVAEHVST-----VVAKPALNSPEE--RPALDVEGI
Mflv_2401|M.gilvum_PYR-GCK LRTFQAIGLVDRVLP--HTVPN----QILRFFDAKRNLLAEMAPPDARFG
MSMEG_4866|M.smegmatis_MC2_155 LRTFQSIGLVDAILP--HTVPN----QILRFYDANRRLLAEMAPPDARFG
Mb1780|M.bovis_AF2122/97 MRLLDELGLWERFAALPYSEVR------TATLHSNGRAVTYIDFERLHQP
Rv1751|M.tuberculosis_H37Rv MRLLDELGLWERFAALPYSEVR------TATLHSNGRAVTYIDFERLHQP
MUL_3663|M.ulcerans_Agy99 LRLLDELGLGSQFAQIPHRLID------TISMKVQGQPVD-LDLKHLPGA
Mvan_4406|M.vanbaalenii_PYR-1 MEIFRDMGIEDQVLADATRHALVG--DTVFCTSIAGEEIGRIHTWGTRPD
MMAR_3384|M.marinum_M LDICVQAGLDVDRMSADAHPPEWD-QFVRFATRLFGEQLGTIAYEYQSPE
: *:
MAB_4357c|M.abscessus_ATCC_199 HLARRLNASPVTIGSCAQDRVQGRLLEAVRSSGMTEVRYRTKVSAVGA--
TH_2800|M.thermoresistible__bu SIERRRAASPVGLISCPQDRIQRLMVDAVLRQGMSRIDYDTRVVEITD--
MAV_2189|M.avium_104 FAGLERFSPEPAAQYCPQSRLEPILLAATRR-GGSDVRYGTELSSIDM--
Mflv_2401|M.gilvum_PYR-GCK WPKRNGFVQP---------MVDAELFGGLQRFDNVEVRFGHRMHQCTQ--
MSMEG_4866|M.smegmatis_MC2_155 WPKRNGFVQP---------MVDAELLAGLDRFDHVEVMWGRRMQTIAE--
Mb1780|M.bovis_AF2122/97 YPYVAMVPQWD---------LLNLLAEAAQAEPSFTLRMKTEVTGLLR--
Rv1751|M.tuberculosis_H37Rv YPYVAMVPQWD---------LLNLLAEAAQAEPSFTLRMKTEVTGLLR--
MUL_3663|M.ulcerans_Agy99 HQHIALVPQWD---------FLELLAAAAEAEPTFRLLRSTEVTGVLWGD
Mvan_4406|M.vanbaalenii_PYR-1 READYRLASPCELVDIPQTYLEPILVRNATS-RGTQTRFSTEYVSHAQ--
MMAR_3384|M.marinum_M WTARPRINLSQ-------PRFEAIVEGDVRQRPGIEWVCGRWTGAQVD--
. :
MAB_4357c|M.abscessus_ATCC_199 --HEDHVDVYLE--KDGHAETLRAEYVVDAEGAAARLRQSIGIDVEGIPE
TH_2800|M.thermoresistible__bu --AATGVEVTAE--SRGKPRRFRADYVVNAEGAGGRLRSALGIEMDGIPF
MAV_2189|M.avium_104 --DEAGVTAVVRDAESGTAETIRADYLIGADGVHSPLRNLLGITTSGYGA
Mflv_2401|M.gilvum_PYR-GCK --TTDRVEVEFD--G--GQASVSARYVVGCDGGRSVTRRLMGVSFDGTTS
MSMEG_4866|M.smegmatis_MC2_155 --DADGVTVEVS--GPDGPASVHAQYVVGCDGGRSATRHLMGVSFDGTTS
Mb1780|M.bovis_AF2122/97 --EGGKVTGVRYQGAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPV
Rv1751|M.tuberculosis_H37Rv --EGGKVTGVRYQGAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPV
MUL_3663|M.ulcerans_Agy99 GPDPGRVVSATYRAQSGETKHMHADLTVACDGRGSTVRSALGMATRSFGA
Mvan_4406|M.vanbaalenii_PYR-1 --DTTGVDVQVRDRLTGNQYTIRAKYLIGADGARSKVAADIGLPFEGAMD
MMAR_3384|M.marinum_M -----KGKVVSTATVDDRQVQFSSRYLIGADGANSAVRESLGISMHTYGQ
. : : .:* . *:
MAB_4357c|M.abscessus_ATCC_199 FGHQIN-MYFHADLSEWTDQESE-LLFWVLNTGCPGV---FIRLGGNRWT
TH_2800|M.thermoresistible__bu IADQVT-SYFHADLSEWTGERPP-LLQWIINTDVQGT---FIAMGQNRWT
MAV_2189|M.avium_104 LPIYVVFVYFRAPWRKFIPHLHDGDGVQVKNADVDGI---FLVAEGDLGM
Mflv_2401|M.gilvum_PYR-GCK STRWLVVDIANDPLGHPNSEVGA-------DPRRPYV---SIAIAHGIRR
MSMEG_4866|M.smegmatis_MC2_155 STRWVVIDLANDPLGHPNSEVGA-------DPQRPYA---SISIAHGIRR
Mb1780|M.bovis_AF2122/97 NFDVWWFKLPREGDAEFSFLPRF-------SPGKGLG---VIPREGYFQI
Rv1751|M.tuberculosis_H37Rv NFDVWWFKLPREGDAEFSFLPRF-------SPGKGLG---VIPREGYFQI
MUL_3663|M.ulcerans_Agy99 PMDVWWFRLPRRPDDPTGLAGIF-------NSGHGGI---AIDRGDYYQI
Mvan_4406|M.vanbaalenii_PYR-1 IAGSMNITFKADIASHVAHRPSVLYWVIQPGANVGGIGAGLVRMVRPWNE
MMAR_3384|M.marinum_M PSHQINAHVVADMREQLTDHPAV--LYALVDPEVAGVAVIHGLGEPGHDN
..
MAB_4357c|M.abscessus_ATCC_199 FHTGFDPAR-EAVSDYTPERCRELIRLAVG--A-PELEIDMRSVGTWVLG
TH_2800|M.thermoresistible__bu FTIGFGATD-EARRALDPQRCVELIRLAIGPAG-SDVDIDFRSAGSWTLC
MAV_2189|M.avium_104 FITTYFPDEGETAEQFTPQRCRELLTKAIG----EPLDIDVIEVAAWQPY
Mflv_2401|M.gilvum_PYR-GCK FEFMIHPDETDEEAD-DPAFVRRMLGQLIP----YPERVDMIRHRVYTHH
MSMEG_4866|M.smegmatis_MC2_155 FEFMIHADETDEQAE-DPEFVAELLRPFVP----HPDRVDVIRRRVYTHH
Mb1780|M.bovis_AF2122/97 AYLGPKGTDAQLRERGIEEFRRDVSELLPEATASVAALASTDEVKHLNVK
Rv1751|M.tuberculosis_H37Rv AYLGPKGTDAQLRERGIEEFRRDVSELLPEATASVAALASMDEVKHLNVK
MUL_3663|M.ulcerans_Agy99 AYIIPKGSDAQLRAQGIEALHRALADLMPWLADRVDALKSFDDVKLLDVQ
Mvan_4406|M.vanbaalenii_PYR-1 WLIVWGYDINDEPPALDEDEAVNIVRQLLG---ISDLPVEITGASLWGNN
MMAR_3384|M.marinum_M TIEWICGSPYDGENVPEMDTIVDRVRKVIG---SDDIGFEVLKLSPWVLT
: .
MAB_4357c|M.abscessus_ATCC_199 ASTARQYRKGRVFLVGDAAHQFPPTGGLGMNTGLVDADNLGWKLAAVLQG
TH_2800|M.thermoresistible__bu ATTARTYRAGRVFLVGDAAHQFPPTGGFGMNTGLADADNLGWKLAAVLHG
MAV_2189|M.avium_104 EQVADRFDCGRAFLVGDSAHTMPPFKAGGANTAIQSAHNLAWKLAAVLRG
Mflv_2401|M.gilvum_PYR-GCK SRIAGSFREGRLMLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVTG
MSMEG_4866|M.smegmatis_MC2_155 SRIAGSFRKGRMLLAGDAAHLMPVWQGQGYNSGIRDAFNLGWKLAAVVRG
Mb1780|M.bovis_AF2122/97 VNRLRRWHIDGLLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLR-
Rv1751|M.tuberculosis_H37Rv VNRLRRWHIDGLLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLR-
MUL_3663|M.ulcerans_Agy99 LNRLRRWYCDGALCIGDAAHAMSPVGGVGINLALADAVATARMLAPSLR-
Mvan_4406|M.vanbaalenii_PYR-1 EMYATHLQQGRVFCAGDAVHRHPPSNGLGSNTSIQDSYNLAWKIAAVLRG
MMAR_3384|M.marinum_M ARVADQFQAGPCFLIGDAAHRLPPTGGLGMNTAIQDGANLAWKLAAVIHG
. : **:.* . . * * .: .. . :* :
MAB_4357c|M.abscessus_ATCC_199 WAHTQLLDTYESERRPVALANAE----------SSIANVMKMADAGIGPN
TH_2800|M.thermoresistible__bu WADEELLDTYESERRPVALANSE----------FSVTNALKMASTGIGPT
MAV_2189|M.avium_104 AAGPALLDTYHAERHPVGVFAAR----------QSLT-GPSMALLRPGGK
Mflv_2401|M.gilvum_PYR-GCK RAGEELLDTYDVERRKHARAMID----------LSTMVGRVISPTN--RK
MSMEG_4866|M.smegmatis_MC2_155 QAGDALLDTYDAERRKHARAMID----------LSTMVGRVISPTN--RK
Mb1780|M.bovis_AF2122/97 --------EHRVSSRHLAAVRRR----------RAFPTAVTQAVQR----
Rv1751|M.tuberculosis_H37Rv --------EHRVSSRHLAAVRRR----------RAFPTAVTQAVQR----
MUL_3663|M.ulcerans_Agy99 --------VGRVSTGQLARVQAR----------RWAPTAFLQGIQR----
Mvan_4406|M.vanbaalenii_PYR-1 QADPALLETYSAERAPIAEQIVKRANKSSREYGQFFEVLGLLDANDEQEM
MMAR_3384|M.marinum_M WAGEALLQSYSTERRPIAIANTLRSLENFEIHIQALAELATAALDGTLHT
. .
MAB_4357c|M.abscessus_ATCC_199 TMAVAAKLESDIPAVAAAERSRMAAAVPEQRPHFDYLELELGYVYGGHND
TH_2800|M.thermoresistible__bu GPQFAAELESDDPSVAAAVRDRIRNAIPEQRPHFDHLELEIGYVYPGDAS
MAV_2189|M.avium_104 RPQLPADEEAP------------------------IFALMIGYRYGANGI
Mflv_2401|M.gilvum_PYR-GCK VAALRDRVIHAASAVPSLKRYVLEMR----------FKPMPRYQQGAVLH
MSMEG_4866|M.smegmatis_MC2_155 VAALRDKLIRGASIVPTLKRYVLEMR----------FKPMPRYHEGAVYH
Mb1780|M.bovis_AF2122/97 --------------------------------------VLHRRLLGPLLQ
Rv1751|M.tuberculosis_H37Rv --------------------------------------VLHRRLLGPLLQ
MUL_3663|M.ulcerans_Agy99 --------------------------------------AIHAAIVAVAVT
Mvan_4406|M.vanbaalenii_PYR-1 AARIEERKAATPRGAAMREALVAAMELKNYEFNAHGVDLGQTYQSAAVVS
MMAR_3384|M.marinum_M MAAERLDNLVQQNSIGFNSP-----------------GLQLGYGYGPNQE
MAB_4357c|M.abscessus_ATCC_199 AVDPITTAV------------MGGRMPHHWVN---LGDRRISTLDLVGVG
TH_2800|M.thermoresistible__bu DGDPVSTPV------------VGGRLPHRWITRITPGQGTASTLDLLGDG
MAV_2189|M.avium_104 ELVDELRAQ------------PGTRVPHVWVR------DGVSTLDLVGPE
Mflv_2401|M.gilvum_PYR-GCK HAHAAPNSP------------TGTLFIQPRVDTR--DTQNALLDDVLGTG
MSMEG_4866|M.smegmatis_MC2_155 AKPPTPASP------------VGTLFIQPRVDTR--EQDNVLLDDVLGTG
Mb1780|M.bovis_AF2122/97 GRDPTPPA------------------------------------------
Rv1751|M.tuberculosis_H37Rv GRDPTPPA------------------------------------------
MUL_3663|M.ulcerans_Agy99 GGPPQPPP------------------------------------------
Mvan_4406|M.vanbaalenii_PYR-1 EGSTLPIPARDPELFYEMSTVPGSHLPHAWVGDSRTKLALMDLAPYTEWT
MMAR_3384|M.marinum_M VADATSFTP---------SAAVGRRLPHAQVKTG--AVDVVPIIDLVDRA
.
MAB_4357c|M.abscessus_ATCC_199 FVLIAGPEGAEWIDAPKIREMRIPLQVYLVG----RDLEPIG-GAIPGAE
TH_2800|M.thermoresistible__bu FTLLTGPAGAAWTAG--VRDVAVPVRTLTAG----VDFAFTGPSDTTFLA
MAV_2189|M.avium_104 FTVLTGDE----------RWCAAAASMSLPA----HRVYNDQWAAITGLA
Mflv_2401|M.gilvum_PYR-GCK FAVVCWSNNLRAVLG----EEAFGRWKALGA----KFVEVRPMSQLRWPG
MSMEG_4866|M.smegmatis_MC2_155 FAVLCWNNNPRTLLG----EAAFTRWKALGA----TFIAARPSTQLHWTK
Mb1780|M.bovis_AF2122/97 --------------------------------------------ALLGLV
Rv1751|M.tuberculosis_H37Rv --------------------------------------------ALLGLV
MUL_3663|M.ulcerans_Agy99 --------------------------------------------VVR-LV
Mvan_4406|M.vanbaalenii_PYR-1 VITGIAGEAWAGAADKVGHELGIPLRTVVIGPGREVTDLYYDWAKLREVD
MMAR_3384|M.marinum_M GFTVFIQGAADPWREASGGSEFPVTIVDLAG-----AVADQGWLELTGLA
MAB_4357c|M.abscessus_ATCC_199 GNGAVLVR-PDGHIAWIGTGLAVDPVEEISLAVETLCGKPLSEIAT----
TH_2800|M.thermoresistible__bu DDGAVLVR-PDGHIAWIATHLPADPAAELTSALRGVHLSADAARSASGQG
MAV_2189|M.avium_104 PDGALLIR-PDDFVGWRADELPTDPQTALRQALSLCLGRAR---------
Mflv_2401|M.gilvum_PYR-GCK HDDPDVAV-IGDRTGALKAWFDVHTESVLFVRPDRCIAAACIAQRAPEIS
MSMEG_4866|M.smegmatis_MC2_155 DDDPDVVI-VGDRTGALKAFFDAHTESVLVLRPDRCIAGADIAQRAPELS
Mb1780|M.bovis_AF2122/97 ERLPWLSA-VPAYFVGVGVRPEHAPAFARRGPGNRKGP------------
Rv1751|M.tuberculosis_H37Rv ERLPWLSA-VPAYFVGVGVRPEHAPAFARRGPGNRKGP------------
MUL_3663|M.ulcerans_Agy99 SRSVPVRR-IMGYLVAIGPLPEHAPKYPRRAR------------------
Mvan_4406|M.vanbaalenii_PYR-1 EDGALLVR-PDKHIAWRSMSMPDQPHAALRSAMAQILGRD----------
MMAR_3384|M.marinum_M HEGAALVVRPDGHIAAKAAGPQSWPGIHSSLRNHLQTGQPLGTEAIA---
: .
MAB_4357c|M.abscessus_ATCC_199 ------------------------------------------------
TH_2800|M.thermoresistible__bu ASR---------------------------------------------
MAV_2189|M.avium_104 ------------------------------------------------
Mflv_2401|M.gilvum_PYR-GCK EGLFAALHLTSGAHLTQGGGTDGEKPDRAVLHVAQPAAESSGTGAGTS
MSMEG_4866|M.smegmatis_MC2_155 TALFGILHLR------QGGENGATGP---VLYVPQPTAESSGTVGRAS
Mb1780|M.bovis_AF2122/97 ------------------------------------------------
Rv1751|M.tuberculosis_H37Rv ------------------------------------------------
MUL_3663|M.ulcerans_Agy99 ------------------------------------------------
Mvan_4406|M.vanbaalenii_PYR-1 ------------------------------------------------
MMAR_3384|M.marinum_M ------------------------------------------------