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M. thermoresistible (build 8) TH_2787 (-)

annotation: AMP-dependent synthetase and ligase
coordinates: 582303 - 583886
length: 528

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2787--100% (528)AMP-dependent synthetase and ligase
M. thermoresistible (build 8)TH_2591-0.060.31% (519) PUTATIVE feruloyl-CoA synthetase
M. thermoresistible (build 8)TH_2878-8e-8237.45% (518) PUTATIVE AMP-binding enzyme, putative

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0172fadD54e-7636.90% (523) acyl-CoA synthetase
M. gilvum PYR-GCKMflv_4559-1e-17658.08% (520) acyl-CoA synthetase
M. tuberculosis H37RvRv0166fadD52e-7637.09% (523) acyl-CoA synthetase
M. leprae Br4923MLBr_02546fadD22e-5830.63% (506) acyl-CoA synthetase
M. abscessus ATCC 19977MAB_4569c-2e-7535.71% (518) fatty-acid-CoA ligase FadD
M. marinum MMMAR_0409fadD55e-7535.94% (512) fatty-acid-CoA ligase FadD5
M. avium 104MAV_5018-8e-7837.77% (511) acyl-CoA synthetase
M. smegmatis MC2 155MSMEG_2883-0.059.14% (514) acyl-CoA synthetase
M. ulcerans Agy99MUL_4126fadD37e-7033.85% (517) acyl-CoA synthetase
M. vanbaalenii PYR-1Mvan_2882-1e-17859.06% (513) acyl-CoA synthetase

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_2883|M.smegmatis_MC2_155      --------------------------------------MLASTRSHALGD
Mvan_2882|M.vanbaalenii_PYR-1       --MIGGAGSSGRLLLSGTRRDCRNHATPTVGRMDDLHAVLASARSHALGD
Mflv_4559|M.gilvum_PYR-GCK          ------------------------------MPEDLLAAQIRRVRSQTVGD
TH_2787|M.thermoresistible__bu      ---------------------------------MVTPDTVSTARSHGLAD
Mb0172|M.bovis_AF2122/97            --------------------MTAQLASHLTRALTLAQQQPYLARRQNWVN
Rv0166|M.tuberculosis_H37Rv         --------------------MTAQLASHLTRALTLAQQQPYLARRQNWVN
MMAR_0409|M.marinum_M               --------------------MTAELASHLPQAA-HALEQPYLARRQNWVN
MAV_5018|M.avium_104                ---------------------MLSLTAQLAHHPTQANEQPYLSRRQNWVN
MAB_4569c|M.abscessus_ATCC_199      --------------------MTDTIDATVQSAG---LAQPYRARRQNWCN
MUL_4126|M.ulcerans_Agy99           ----------------------------------------MTSDPRTVPT
MLBr_02546|M.leprae_Br4923          MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
                                                                                      

MSMEG_2883|M.smegmatis_MC2_155      IPRRSARRCPDKVAIIDGDVTLTFAEFEHHVDRAAAALQDNGFGVGDRVA
Mvan_2882|M.vanbaalenii_PYR-1       IPRRSARKQPDKIAIIDGDVCLSFAEFERLVDRAAAALSDNGFGVGDRLA
Mflv_4559|M.gilvum_PYR-GCK          IPRRSARRHPHKLAIVDGTTRLTFAELDAHVDRVASALRDSGFGKGDRIA
TH_2787|M.thermoresistible__bu      LLRRSATRFPDKTALVTPDTALTFDKLDGLVDHVAAALDERGLHKGGRLA
Mb0172|M.bovis_AF2122/97            QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
Rv0166|M.tuberculosis_H37Rv         QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
MMAR_0409|M.marinum_M               QLERHAMMQPRATAIRYLGHTVTWADLRYRVAALAGSLSRRGVGFGDRVM
MAV_5018|M.avium_104                QLERHALMQPNATALRFLGKGLTWGELHGRVRALADALSRRGVGFGDRVM
MAB_4569c|M.abscessus_ATCC_199      QLARHALMQPDATAIRYLGHSISWAELHQRVQALADALSRRGVGFGDRVL
MUL_4126|M.ulcerans_Agy99           ALDRLVRRLPNHDALVTDERSFTVSELNDEVYRAAAALIELGVKPAARVG
MLBr_02546|M.leprae_Br4923          LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
                                         .   *   *:      .:  .:   .   * .*   *.  .  : 

MSMEG_2883|M.smegmatis_MC2_155      VLAHNCWQYAVLAFATARAGVVLVPVNFMLTAEEICYILGHSRAGGFLVE
Mvan_2882|M.vanbaalenii_PYR-1       LLAHNCWQYAVLAFATARAGVVLVPINFMLTAEEISFILGHSQVTGFVVE
Mflv_4559|M.gilvum_PYR-GCK          LLSHNCWQYAVLAFATARAGVVMVPVNFMLGPDEIAFILGHSKVTGFVVE
TH_2787|M.thermoresistible__bu      ILSRNNWQFVVAAYAAARCGVLLVPINFMLTAEEVAYILEHSQADGIIAG
Mb0172|M.bovis_AF2122/97            ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCAAHVMLTE
Rv0166|M.tuberculosis_H37Rv         ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCVAHVMLTE
MMAR_0409|M.marinum_M               ILMLNRTEFVESVLAANMLGAIAVPLNFRLTPSEIAFLVEDCAPRLVITE
MAV_5018|M.avium_104                VLMLNRPEFMESVLAINMLGAIAVPLNFRLTAAEIAFLVQDCQARVVITE
MAB_4569c|M.abscessus_ATCC_199      ILMLNRPEYVESWLAINELGAIAIPVNFRMTPPEVAFLVENSGAKVAITE
MUL_4126|M.ulcerans_Agy99           IWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAM
MLBr_02546|M.leprae_Br4923          ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
                                    :   *   :     .    *.  : :*      :   :         .  

MSMEG_2883|M.smegmatis_MC2_155      ADLVPTAEAAMRLGGS--VTTTAALVLPGQGLP-AGWTDFDRWLQTDSP-
Mvan_2882|M.vanbaalenii_PYR-1       ADLVPTAEAAMQLAGN--VATGAALVPPGQSLP-DGWTDFAQWLQTDST-
Mflv_4559|M.gilvum_PYR-GCK          TALVPVADEAMAAAGEDCAVTTRIAITSGDPVP-AGWQDYAHWSQSAATP
TH_2787|M.thermoresistible__bu      EEFCGTAQAALAQIER--TVHARAVIGDSSGVAGDSWENFDDWSLTAGA-
Mb0172|M.bovis_AF2122/97            AALAPVAIGVRNIQPLLSVIVVAGGSSQDSVFG------YEDLLNEAGDV
Rv0166|M.tuberculosis_H37Rv         AALAPVAIGVRNIQPLLSVIVVAGGSSQDSVFG------YEDLLNEAGDV
MMAR_0409|M.marinum_M               EVLAQVAVGVREIAPALSTIVVAGGASDPTVVG------YDELISETGDP
MAV_5018|M.avium_104                AVLAPVATGVRDIESLLDTVVVAGGSSDDAVLG------YDDLIDETGAA
MAB_4569c|M.abscessus_ATCC_199      TVLAPVAAAVRQQAPALETVIVAGSASENGVLG------YEEVIAEPGEP
MUL_4126|M.ulcerans_Agy99           GHFLGSDRVAGLDRKALPALRHIVRIPIEEPDG-TWDEFIETGTDTGAVT
MLBr_02546|M.leprae_Br4923          DEYTKVVSKAEPALGKLRALGVNPDEEEPPGST-----DETLAELIARSS
                                             .        .                               

MSMEG_2883|M.smegmatis_MC2_155      APAPYVADDQMIRLMYTSGTESHPKGAMHSTRSLMGNYISSIIAGSMEG-
Mvan_2882|M.vanbaalenii_PYR-1       APNPHIDDDQLIRLMYTSGTESHPKGAQHSSRSLMGNYVSTIIAGSMES-
Mflv_4559|M.gilvum_PYR-GCK          APAVEIADDDVLRLMYTSGTESRPKGVMHTSRSLMWQYISSIVAGSMSG-
TH_2787|M.thermoresistible__bu      APQVAVADDEPIRIMYTSGTESRPKGVLLSSRSLVHSYLSVIVGGEMCA-
Mb0172|M.bovis_AF2122/97            HEPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYTSGANIN
Rv0166|M.tuberculosis_H37Rv         HEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSGANIN
MMAR_0409|M.marinum_M               PEPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLTGQVMTALYTGGANIN
MAV_5018|M.avium_104                HQPVDIPNDAAALIMYTSGTTGRPKGAVLTHTNLTGQTMTGLYTNGADIN
MAB_4569c|M.abscessus_ATCC_199      HAEVDLPGDTPALIMYTSGTTGRPKGAVLTHLNLSGQAMTYLLSTTVDLN
MUL_4126|M.ulcerans_Agy99           ARAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITA-
MLBr_02546|M.leprae_Br4923          SAPAPKVRKRASIIILTSGTTGTPKGANRN-TPASLAPLGGILSKVPFRA
                                            .    :: *:** . .**.                       

MSMEG_2883|M.smegmatis_MC2_155      TDIEIHSLPLYHCAQMDNFFITDIYLGATSIILPR--PEPELVLRTIEKY
Mvan_2882|M.vanbaalenii_PYR-1       ADIEIHSLPLYHCAQLDNFLITDVYLGATSIIVSR--PDPELVLRTIEKH
Mflv_4559|M.gilvum_PYR-GCK          EDVEIHSMPLYHCAQLDNFLITDVYLGATSIILPG--PDPEAILRTIEAE
TH_2787|M.thermoresistible__bu      EDIDLHTMPLYHCAQLDCFLGPDIYLGATSVVLPK--PDPVAILTAIERH
Mb0172|M.bovis_AF2122/97            SDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAE
Rv0166|M.tuberculosis_H37Rv         SDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAE
MMAR_0409|M.marinum_M               SDVGFIGVPFFHIAGIG-NMLSGMLLGVPTVIYPLGAFNPGQLLDVLEAE
MAV_5018|M.avium_104                NDVGFIGVPFFHIAGIG-NMLTGLLLGIPTVIYPLGAFEPGQLLDVLAAE
MAB_4569c|M.abscessus_ATCC_199      SDVGFIGVPMFHIAGVG-NMITGLLLGLPTVIHPLGAFDPGALLDVLESE
MUL_4126|M.ulcerans_Agy99           DDRHLCINPFFHNFGYKAGILACLQTGAT--LFPHLTFDPLRTLQAIERH
MLBr_02546|M.leprae_Br4923          HEVTLLPAPMFHALGYLHATLA-MFLGSTLVLRRR--FKPATVLEDIEKH
                                     :  :   *::*         . :  * .  :      .*   *  :   

MSMEG_2883|M.smegmatis_MC2_155      GVTNYFAPPTVWISLLRSPV--FDQVDLTSLRKGYYGASAMPVEILAEMR
Mvan_2882|M.vanbaalenii_PYR-1       EVTNYFAPPTVWISLLRSPV--FDQVDLSSLRKGYYGASAMPVEILAEMR
Mflv_4559|M.gilvum_PYR-GCK          QVTNFFAPPTVWIALLRCPA--FDRYDLTSLRKGYYGASAMPREILHELR
TH_2787|M.thermoresistible__bu      GVTKFFAPPTVWISLLRSPR--FSDFDLTSLRKGYYGASSMPIEVLNEIR
Mb0172|M.bovis_AF2122/97            KVTGIFLVPAQWQAVCTEQQ--ARPRDLR-LRVLSWGAAPAPDALLRQMS
Rv0166|M.tuberculosis_H37Rv         KVTGIFLVPAQWQAVCTEQQ--ARPRDLR-LRVLSWGAAPAPDALLRQMS
MMAR_0409|M.marinum_M               RVSGIFLVPAQWQAVCAEQQ--ARPRELS-LRVMSWGAAPAPDALLRQMS
MAV_5018|M.avium_104                KVTGIFLVPAQWQAVCAEQR--ARPRDLK-LRVISWGAAPAPDALLREMS
MAB_4569c|M.abscessus_ATCC_199      GVTGIFLVPAQWQAVCAAQQ--ANPRKVR-LKTLSWGAAPATDVLLRTMS
MUL_4126|M.ulcerans_Agy99           RITVLPGPPTIYQTLLDHPA--RDDYDLSSLRFAVTGAATVPVVLVERMQ
MLBr_02546|M.leprae_Br4923          QATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRAL
                                      :     *.    :           .:  *:    ..:     :     

MSMEG_2883|M.smegmatis_MC2_155      ERLPNLRLWNFYGQTEMAPLASALGPDE-QDAHAGAAGRPVINVETAILD
Mvan_2882|M.vanbaalenii_PYR-1       ERLPNLRLWNFYGQTEMAPLASALGPDE-QDAHAGSAGRPVINVETAILD
Mflv_4559|M.gilvum_PYR-GCK          DRLPNVSLWNFYGQTEIAPLASSLGPDE-QDRHGGAAGRPAVNVETAILD
TH_2787|M.thermoresistible__bu      TRLPELRLWNLYGQTEMSPVATILGPEE-QESKAGSAGYPALNVETAVVD
Mb0172|M.bovis_AF2122/97            ATFPETQILAAFGQTEMSPVTCMLLGED-AIAKRGSVGRVIPTVAARVVD
Rv0166|M.tuberculosis_H37Rv         ATFPETQILAAFGQTEMSPVTCMLLGED-AIAKRGSVGRVIPTVAARVVD
MMAR_0409|M.marinum_M               EVFPGTQIMAAFGQTEMSPVTCMLLGED-AIRKRGSVGKVIPTVSARVVD
MAV_5018|M.avium_104                AMFPGTQILAAFGQTEMSPVTCMLLGED-AIRKRGSVGKVIPTVAARVVD
MAB_4569c|M.abscessus_ATCC_199      ETFPDARILAAFGQTEMSPVTCMLMGDD-AIRKMGSVGRVIPTVSARVVD
MUL_4126|M.ulcerans_Agy99           SELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGRPFADFELRIGP
MLBr_02546|M.leprae_Br4923          EELG-PVIYNMYGSTEIA-FATIAGPKD-LQINSATVGPVVKGVKVKILD
                                      :    :   :* **   .      .:       : *     .   :  

MSMEG_2883|M.smegmatis_MC2_155      DDNRPVPPGEVGEIAHRSPHLMLGYLDDEAKTAEAFRGG-WFHSGDLGYY
Mvan_2882|M.vanbaalenii_PYR-1       DDNSPVAPGVVGEIAHRSPHLMLGYLDDDAKTAESFRGG-WFHSGDLGYY
Mflv_4559|M.gilvum_PYR-GCK          DSDNPVPPGTVGEIAHRSPHLMVGYLDDPQRTAEAFRGD-WFHSGDLGYY
TH_2787|M.thermoresistible__bu      EAGSSVPPGTVGEIVHRSPHLTLGYWRDDLKTVEAFRDG-WFHSGDLGFF
Mb0172|M.bovis_AF2122/97            QNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGG-WFHSGDLVRM
Rv0166|M.tuberculosis_H37Rv         QNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGG-WFHSGDLVRM
MMAR_0409|M.marinum_M               DEMNDVPIGQVGEIVYRAPTLMSGYWNNPDATAEAFAGG-WFHSGDLVRM
MAV_5018|M.avium_104                ENMNDVPVGEVGEIVYRAPTLMSGYWNNPEATAEAFAGG-WFHSGDLVRM
MAB_4569c|M.abscessus_ATCC_199      DNMNDVPVGEVGEIVYRAPTLMQGYWNNPEATADAFAGG-WFHSGDLVRQ
MUL_4126|M.ulcerans_Agy99           DT---------GEVLLRGPNVMLGYLDDPRATAAAIDADGWLHTGDIGVL
MLBr_02546|M.leprae_Br4923          DSGKEVPRGQVGRIFVGNAFPFEGYTGGG---GKQIIDG-LLSSGDVGYF
                                    :          *.:    .     *  .       :  .  : :**:   

MSMEG_2883|M.smegmatis_MC2_155      DEHGLLHVVDRKKDMIKTGGENVASREVEEAVYRHPAVEEVAVFGLPHPT
Mvan_2882|M.vanbaalenii_PYR-1       DGHGLLHVVDRKKDMIKTGGENVASREVEEVIYRHSAVEEVAVFGLPHPV
Mflv_4559|M.gilvum_PYR-GCK          DEFGLLHVVDRKKDMIKSGGENVASREVEEVLYQHDDVQEAAVFGLPHPV
TH_2787|M.thermoresistible__bu      DDDGCLTVVDRKKDMIKTGGENVASREVEEVIYQHPGVAEVAVFGVPHPK
Mb0172|M.bovis_AF2122/97            DSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRADEK
Rv0166|M.tuberculosis_H37Rv         DSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRADEK
MMAR_0409|M.marinum_M               DEDGYVWVVDRKKDMIISGGENVYCAEVENVLASHPSIVEVAVIGRADEK
MAV_5018|M.avium_104                DEDGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRAHEK
MAB_4569c|M.abscessus_ATCC_199      DEDGFVWVVDRKKDMIISGGENIYCAEVENALAEHEQIAEVAVIGRPHEK
MUL_4126|M.ulcerans_Agy99           DEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADVAVIGIPDHR
MLBr_02546|M.leprae_Br4923          DEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVDDKE
                                    *  . : : .* .:*   ** *:   *:*: :     : :.:.:*  .  

MSMEG_2883|M.smegmatis_MC2_155      WVEAVVAAVVTRDGAELTEDELLTHCRSCLAGFKTPKQVFFVESLPKNPS
Mvan_2882|M.vanbaalenii_PYR-1       WVEAVVAAVVVRDGMEVTEDELASHCRAHLAGFKTPKQVYFVDSLPKNPS
Mflv_4559|M.gilvum_PYR-GCK          WVEAVVAAVVPREGRVLDPDAVIAHCRSRLAGFKTPKQIFTVAELPKNPS
TH_2787|M.thermoresistible__bu      WIEAVCAAVVPRQGATLDEETVAAHCSGRLAGFQTPKHVFIVETLPKNPS
Mb0172|M.bovis_AF2122/97            WGEVPIAVAAVTN-DDLRIEDLGEFLTDRLARYKHPKALEIVDALPRNPA
Rv0166|M.tuberculosis_H37Rv         WGEVPIAVAAVTN-DDLRIEDLGEFLTDRLARYKHPKALEIVDALPRNPA
MMAR_0409|M.marinum_M               WGEVPIAVAAVTK-DHLRIEDLDEYLTERLARYKHPKALEIVDALPRNPS
MAV_5018|M.avium_104                WGEVPIAVAAVAN-DNLALEDLDEFLTERLARYKHPKALEIVDALPRNPA
MAB_4569c|M.abscessus_ATCC_199      WGEVPVAVAAIHG-AALTLAELDGFLTARLARYKHPKDLVIVDALPRNPS
MUL_4126|M.ulcerans_Agy99           LGEVGRAFIVARPGFNLDEKSVIDYTREHLANFKAPRSVRFVDTLPRNAG
MLBr_02546|M.leprae_Br4923          WGARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREVIFLEELPRNPT
                                          *  .      :    :  .    ** :: *: :  :  **:*. 

MSMEG_2883|M.smegmatis_MC2_155      GKLLKRVLRERFARTTTDAI-----------------
Mvan_2882|M.vanbaalenii_PYR-1       GKLLKRSLREQFG-VDRGALS----------------
Mflv_4559|M.gilvum_PYR-GCK          GKLLKRELRERFASAMN--------------------
TH_2787|M.thermoresistible__bu      GKILKRELRNTFSALLNHPE-----------------
Mb0172|M.bovis_AF2122/97            GKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
Rv0166|M.tuberculosis_H37Rv         GKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
MMAR_0409|M.marinum_M               GKVLKTELRLRYGVGVYSESRSVSRSFEFREGS----
MAV_5018|M.avium_104                GKVLKTELRIRYGGG----------------------
MAB_4569c|M.abscessus_ATCC_199      GKVLKTELRQRFGIAD---------------------
MUL_4126|M.ulcerans_Agy99           GKVVKPQLRELA-------------------------
MLBr_02546|M.leprae_Br4923          GKVLKRELRDFEVH-----------------------
                                    **::*  **