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MAEPLAVDPTGLSAAAAKLAGLVFPQPPAPIAVSGTDSVVAAINETMPSIESLVSDGLPGVKAALTRTAS NMNAAADVYAKTDQSLGTSLSQYAFGSSGEGLAGVASVGGQPSQATQLLSTPVSQVTTQLGETAAELAPR VVATVPQLVQLAPHAVQMSQNASPIAQTISQTAQQAAQSAQGGSGPMPAQLASAEKPATEQAEPVHEVTN DDQGDQGDVQPAEVVAAARDEGAGASPGQQPGGGVPAQAMDTGAGARPAASPLAAPVDPSTPAPSTTTTL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3878 | - | - | 100% (280) | CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN |
| M. tuberculosis H37Rv | Rv3439c | - | 4e-06 | 26.40% (250) | hypothetical protein Rv3439c |
| M. tuberculosis H37Rv | Rv3892c | PPE69 | 8e-05 | 24.21% (252) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3908 | - | 1e-153 | 99.64% (280) | hypothetical protein Mb3908 |
| M. gilvum PYR-GCK | Mflv_0763 | - | 7e-22 | 33.47% (248) | hypothetical protein Mflv_0763 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1945c | - | 8e-06 | 23.87% (222) | dihydrolipoamide succinyltransferase |
| M. marinum M | MMAR_5453 | - | 3e-57 | 50.53% (281) | hypothetical protein MMAR_5453 |
| M. avium 104 | MAV_4644 | - | 7e-05 | 23.81% (252) | hypothetical protein MAV_4644 |
| M. smegmatis MC2 155 | MSMEG_0069 | - | 6e-11 | 26.69% (251) | translation initiation factor IF-2 protein |
| M. thermoresistible (build 8) | TH_2875 | - | 2e-11 | 27.19% (228) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4594 | - | 1e-43 | 40.29% (273) | hypothetical protein MUL_4594 |
| M. vanbaalenii PYR-1 | Mvan_0082 | - | 2e-18 | 32.65% (245) | hypothetical protein Mvan_0082 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3878|M.tuberculosis_H37Rv ----MAEPLAVDPTGLSAAAAKLAG----------LVFPQPPAPIAVSGT
Mb3908|M.bovis_AF2122/97 ----MAEPLAVDPTGLSAAAAKLAG----------LVFPQPPAPIAVSGT
MMAR_5453|M.marinum_M ----MAEPLAVDPARLIAAGSKLAE----------LVFPAPPAPIAATGG
MUL_4594|M.ulcerans_Agy99 ----MAEPLAVDPAGLGAVGTRLRG----------LVFPTPPALIVAAGT
Mflv_0763|M.gilvum_PYR-GCK MVSGGLPPLSVDPTQLSAAGGALKSS--------ALDLPEAPAPFMPVGT
Mvan_0082|M.vanbaalenii_PYR-1 MATGGTPPLSVDPEELSAAGGALLDS--------ARELPQAPAPFNPVGT
TH_2875|M.thermoresistible__bu -------LTAAISERITEVVDPVIE-----------ALPVTKEELKQFAQ
MSMEG_0069|M.smegmatis_MC2_155 ---------------MEASAR---------------AIPEPPDPFKTEGT
MAV_4644|M.avium_104 -----MAPLACDPTALDHAGATVVAAGESLGSVISTLTAALAGTSGMAGD
MAB_1945c|M.abscessus_ATCC_199 MAFSVQMPALGESVTEGTVTRWLKQE---------GDTVEVDEPLLEVST
.
Rv3878|M.tuberculosis_H37Rv DSVVAAINETMPSIESLVSD------------GLPGVKAALTRTASNMNA
Mb3908|M.bovis_AF2122/97 DSVVAAINKTMPSIESLVSD------------GLPGVKAALTRTASNMNA
MMAR_5453|M.marinum_M DPVSAAINDTMPGIESLVSD------------GMPGVTAALKRTASSMST
MUL_4594|M.ulcerans_Agy99 DALSVAINTAMPNIESSVTD------------LLPSAKADMANTASSMAT
Mflv_0763|M.gilvum_PYR-GCK DPLSVAIIGQIPAIETPIAT------------QLPLIKAEATTTASNVED
Mvan_0082|M.vanbaalenii_PYR-1 DPLSAAIIGQIPAVEAPIAT------------QLPLIQAQATSTAQNVVS
TH_2875|M.thermoresistible__bu N--VVSAADEYDAKDRQIAE------------EILKQIGAFDEPPAHGGA
MSMEG_0069|M.smegmatis_MC2_155 DPLSKALADKTWQVEAPFIE------------GIGKTKAEAQETARRIQE
MAV_4644|M.avium_104 DPVGAALGRRYDGAAAKLIQ------------AMADTRNGLCSIGDGVRM
MAB_1945c|M.abscessus_ATCC_199 DKVDTEIPAPTSGVLTKIVAREDDTVEIGGELGVISEAGEAAPAAPAPAP
: . :
Rv3878|M.tuberculosis_H37Rv AADVYAKTDQS-----LGTSLSQYAFG---SSGEGLAGV---ASVGGQPS
Mb3908|M.bovis_AF2122/97 AADVYAKTDQS-----LGTSLSQYAFG---SSGEGLAGV---ASVGGQPS
MMAR_5453|M.marinum_M AADIYAKADQA-----LGDALTQYQFG---GDGQALGASGANAVAQSQAG
MUL_4594|M.ulcerans_Agy99 AADIYTKVDES-----LGENLSQHQFR---GSAPILTGS----TVTDQAG
Mflv_0763|M.gilvum_PYR-GCK AAQAYAATDEQ-----NSAAIDQVMQK---TPSQMPSGSGG----SAPGG
Mvan_0082|M.vanbaalenii_PYR-1 AAQVYAETDAR-----NGAAIHEQMQS---RLDPLGTGSGGGSLPSTAGG
TH_2875|M.thermoresistible__bu VPSGGSSAVTG-----PSSPLSAAGAS---VGGMTGASVGG---AAGQAG
MSMEG_0069|M.smegmatis_MC2_155 AADKYEQSDRT-----IAENLQSSTGR---FDASTGTEGTS-QGGLQGLE
MAV_4644|M.avium_104 SAHNYAVAEAMSDLAGRASALPAPQVTGPLTVGAPPSAVGHGSGAPAGWG
MAB_1945c|M.abscessus_ATCC_199 APAAAPAPEPTPAPAPEATATAAPEPAAEPPAAAAPAGSGTSVKMPELGE
. .
Rv3878|M.tuberculosis_H37Rv QATQLLSTP---------------------------VSQVTTQLGETAAE
Mb3908|M.bovis_AF2122/97 QATQLLSTP---------------------------VSQVTTQLGETAAE
MMAR_5453|M.marinum_M QTVQSLAAPAAGLLGAPVAQALAAPATGLLGVPAAAATQIGEAVSAQAEA
MUL_4594|M.ulcerans_Agy99 QFVQSMAT---------SAWQWADRAR------QGVETLI-DQLSPQISE
Mflv_0763|M.gilvum_PYR-GCK GADAAGQMS--------------------------QMMGMPMQMAQMPMQ
Mvan_0082|M.vanbaalenii_PYR-1 GADSLGMPM--------------------------QMAG---QMAQMPMQ
TH_2875|M.thermoresistible__bu GFEQMMGMP----------------------------MQMAQQAAQMPMQ
MSMEG_0069|M.smegmatis_MC2_155 QLQQMMQMP----------------------------MQAVQMAAQVPTQ
MAV_4644|M.avium_104 WVAPSIGMIWPTGDSAKLRAAAAAWATAGANFMAAETAAGGGTMAAIGAQ
MAB_1945c|M.abscessus_ATCC_199 SVTEGTVTRWLKKVGDEVGVDEPLVEVSTDKVDTEIPSPVAGVLLSISAN
Rv3878|M.tuberculosis_H37Rv LAPRVVATVPQLVQLAPHAVQMSQNAS-----------------------
Mb3908|M.bovis_AF2122/97 LAPRVVATVPQLVQLAPHAVQMSQNAS-----------------------
MMAR_5453|M.marinum_M LSPRVAATIPQLVQLAPQAGQMAQQAS-----------------------
MUL_4594|M.ulcerans_Agy99 VAAQVAEAGPQLAQLGSQAAFVAQYAS-----------------------
Mflv_0763|M.gilvum_PYR-GCK MMSGIASAPQGLMQGAQQASQQVQQMA-----------------------
Mvan_0082|M.vanbaalenii_PYR-1 VMGAVAAVPQGIMQGAQQAGQQVQQMV-----------------------
TH_2875|M.thermoresistible__bu MGGMAGQLPQQLAQGAQGAMEQVTQLS-----------------------
MSMEG_0069|M.smegmatis_MC2_155 MAQMAAQVPQTVMQGVQQIGQMSGGTG-----------------------
MAV_4644|M.avium_104 QIPEGAAINKALADASSATADVARQCQTIAAQLNSYAAKVDQVHAAILDL
MAB_1945c|M.abscessus_ATCC_199 EDDTVAVGGELAVVGAADAAPAAPAAPAAPAP------------------
Rv3878|M.tuberculosis_H37Rv ---------------------------PIAQTISQTAQQAAQSAQGGSGP
Mb3908|M.bovis_AF2122/97 ---------------------------PIAQTISQTAQQAAQSAQGGSGP
MMAR_5453|M.marinum_M ---------------------------PIAQTISQSAQQ----GSSQGGA
MUL_4594|M.ulcerans_Agy99 ---------------------------PMAQSIGQSTQQIVSTASQAGGA
Mflv_0763|M.gilvum_PYR-GCK ---------------------------GQFG-QGATGGSASSAAQVPAPD
Mvan_0082|M.vanbaalenii_PYR-1 ---------------------------GQFGDQGAKDGQKG----TPSGE
TH_2875|M.thermoresistible__bu ---------------------------GLADGDQQGLGD-----DQAGEA
MSMEG_0069|M.smegmatis_MC2_155 ---------------------------QDSAGPAAPQTDSPVGKSKGGRE
MAV_4644|M.avium_104 LSRICDPLTGIKEVWDLLTDEDEDEIKKIADDIRTVVDNFGREADTLGGQ
MAB_1945c|M.abscessus_ATCC_199 ---------------------------EPAAAPAAAAAPPAPPAPAPAPA
.
Rv3878|M.tuberculosis_H37Rv MPAQLASAEKPAT-------------------------------------
Mb3908|M.bovis_AF2122/97 MPAQLASAEKPAT-------------------------------------
MMAR_5453|M.marinum_M APAQ----------------------------------------------
MUL_4594|M.ulcerans_Agy99 APAQHG--------------------------------------------
Mflv_0763|M.gilvum_PYR-GCK APAPEP--------------------------------------------
Mvan_0082|M.vanbaalenii_PYR-1 LPTAAN--------------------------------------------
TH_2875|M.thermoresistible__bu VDGVMS--------------------------------------------
MSMEG_0069|M.smegmatis_MC2_155 RDDQQE--------------------------------------------
MAV_4644|M.avium_104 IEATVSAVAAATENMSHWAGKEWDHFLHGTPVGRALNQVGQAFKGVGEEG
MAB_1945c|M.abscessus_ATCC_199 APAPASTAPAANG-------------------------------------
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5453|M.marinum_M --------------------------------------------------
MUL_4594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0082|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2875|M.thermoresistible__bu --------------------------------------------------
MSMEG_0069|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4644|M.avium_104 WGFLKGLYEVSPNRMLLDPVGYGKTMAGMVEGAGTLVGLGPDGVPGAFDA
MAB_1945c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5453|M.marinum_M --------------------------------------------------
MUL_4594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0082|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2875|M.thermoresistible__bu --------------------------------------------------
MSMEG_0069|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4644|M.avium_104 WKALGKDVTHWDEWGSNPAEALGKSTFDVATLALPGGPLSKLGKFGHSAA
MAB_1945c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3878|M.tuberculosis_H37Rv ----EQAEPVHEVTNDDQGD-QGDVQPAEVVAAARDEGAGASPGQQPGGG
Mb3908|M.bovis_AF2122/97 ----EQAEPVHEVTNDDQGD-QGDVQPAEVVAAARDEGAGASPGQQPGGG
MMAR_5453|M.marinum_M --------LVSDTKPDEDAELADETKEGEEDAMAAAGAEGAAAGHATLVS
MUL_4594|M.ulcerans_Agy99 -------LLVDDMKADD----ADD----ERDAKAGADGAGAAPGSQTLGG
Mflv_0763|M.gilvum_PYR-GCK ---------------------------ASEGAAAGEPDAERAPTPDERSD
Mvan_0082|M.vanbaalenii_PYR-1 ---------------------------REEGAAAAEPHAERAPEPEEKTD
TH_2875|M.thermoresistible__bu ---------------------------EQASAEPESQIPAAVAEQQEQTD
MSMEG_0069|M.smegmatis_MC2_155 ---------------------------QHEGAAADPAFTQQAPVTSQVPG
MAV_4644|M.avium_104 DALKGLKKPPGVPKPPEVKPPAAPKAPDSGQPAPSGKPGPVAPSGKPAPG
MAB_1945c|M.abscessus_ATCC_199 -------AAGDNPYVTPLVRKLAAENNVDLSALSGSGVGGRIRKQDVLAA
. .
Rv3878|M.tuberculosis_H37Rv VPAQAMDTGAG-ARPAASPLAAPVDPSTPAPSTTTTL-------------
Mb3908|M.bovis_AF2122/97 VPAQAMDTGAG-ARPAASPLAAPVDPSTPAPSTTTTL-------------
MMAR_5453|M.marinum_M AP---VESTGG-GETSTGSVSAPI--------------------------
MUL_4594|M.ulcerans_Agy99 AP---IEGGTG-TTADNQSAGPDVTVL-----------------------
Mflv_0763|M.gilvum_PYR-GCK RE----DTGAP-GRHRAAEADDRIDL------------------------
Mvan_0082|M.vanbaalenii_PYR-1 TD----GGQRP-GRHRAAESDERIEL------------------------
TH_2875|M.thermoresistible__bu QP---GERAPV-GSPSARSAVSDAEIVL----------------------
MSMEG_0069|M.smegmatis_MC2_155 AAASEPEAGHSEGRPRANGTVPRPVPSDPAIVL-----------------
MAV_4644|M.avium_104 PADGPLPHSPTESKPPAGGTPPAAEPPKPTAAPHSGEPKPIATPPESVGK
MAB_1945c|M.abscessus_ATCC_199 AEAAKAPAAAPAPAAPAASAPAAVAPSLAHLRGTTQKANRIR--QITAKK
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5453|M.marinum_M --------------------------------------------------
MUL_4594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0082|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2875|M.thermoresistible__bu --------------------------------------------------
MSMEG_0069|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4644|M.avium_104 PVTPAPAEGAPAQPHEPVSARVPPTVPAADTPAPSAPAASMSAASGPPMP
MAB_1945c|M.abscessus_ATCC_199 TRESLQETAQLTQTHEVDVTKIAALRARAKAAFAEREGVNLTFLPFFAKA
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5453|M.marinum_M --------------------------------------------------
MUL_4594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0082|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2875|M.thermoresistible__bu --------------------------------------------------
MSMEG_0069|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4644|M.avium_104 PTPSLPEPASLPSGPSGDLPAETPPTAGIPHSGEPSAPSSVPPHFPDTPT
MAB_1945c|M.abscessus_ATCC_199 AVEALKTHPNVNASYNEESKEITYFDAEHLGIAVDTDQGLLSPVIHNAGD
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5453|M.marinum_M --------------------------------------------------
MUL_4594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0082|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2875|M.thermoresistible__bu --------------------------------------------------
MSMEG_0069|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4644|M.avium_104 HGLGDGGAHGPPESDPKNANGHGPHDASLDSGSDHHLPLHPLDSDDLAAL
MAB_1945c|M.abscessus_ATCC_199 LSLAGLARAIADIAARARSGNLKPDELAGGTFTITNIGSQGALFDTPILV
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5453|M.marinum_M --------------------------------------------------
MUL_4594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0082|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2875|M.thermoresistible__bu --------------------------------------------------
MSMEG_0069|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4644|M.avium_104 AHYTGPGYQELNFALREGALDVSQQARVDALQKALEKLPVYEGAVVRGTN
MAB_1945c|M.abscessus_ATCC_199 PPQAAMLGTGAIVKRPRVIRDDAGNESIGIRSVCYLPLTYDHRLIDGADA
Rv3878|M.tuberculosis_H37Rv --------------------------------------------------
Mb3908|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5453|M.marinum_M --------------------------------------------------
MUL_4594|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0082|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2875|M.thermoresistible__bu --------------------------------------------------
MSMEG_0069|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4644|M.avium_104 LPADVLEQYRPGEVITEAAFTSTSTDHTVAQSSAFAGNTEFRIWSTTGRD
MAB_1945c|M.abscessus_ATCC_199 GRFLTTIKHRLEEGAFEADLGL----------------------------
Rv3878|M.tuberculosis_H37Rv ------------------------------------------
Mb3908|M.bovis_AF2122/97 ------------------------------------------
MMAR_5453|M.marinum_M ------------------------------------------
MUL_4594|M.ulcerans_Agy99 ------------------------------------------
Mflv_0763|M.gilvum_PYR-GCK ------------------------------------------
Mvan_0082|M.vanbaalenii_PYR-1 ------------------------------------------
TH_2875|M.thermoresistible__bu ------------------------------------------
MSMEG_0069|M.smegmatis_MC2_155 ------------------------------------------
MAV_4644|M.avium_104 VSSVSMYPDEKEILFPAGSKFYVVSKTVDPQTGRTIIEMIER
MAB_1945c|M.abscessus_ATCC_199 ------------------------------------------