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TAPIWFASPPEVHSALLSAGPGPASLQAAAAEWTSLSAEYASAAQELTAVLAAVQGGAWEGPSAEAYVAA HLPYLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3739c | PPE67 | - | 100% (77) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3022c | PPE48 | 8e-30 | 72.73% (77) | PPE family protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 8e-30 | 72.73% (77) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 3e-30 | 74.03% (77) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 8e-29 | 70.13% (77) | PPE protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 3e-22 | 60.53% (76) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 5e-28 | 69.74% (76) | PPE family protein |
| M. marinum M | MMAR_2944 | - | 2e-30 | 76.32% (76) | PPE family protein |
| M. avium 104 | MAV_4349 | - | 3e-30 | 75.32% (77) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 7e-30 | 76.32% (76) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-30 | 77.92% (77) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1202 | - | 4e-28 | 76.39% (72) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-29 | 72.73% (77) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3739c|M.tuberculosis_H37Rv ----------MTAPIWFASPPEVHSALLSAGPGPASLQAAAAEWTSLSAE
Mb3047c|M.bovis_AF2122/97 ----------MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAV_4349|M.avium_104 ----MTTVPAMTAPIWMASPPEVHSALLSSGPGPASVFAAAAAWSALGAE
MUL_1202|M.ulcerans_Agy99 --------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
MMAR_2944|M.marinum_M ----------MTAPIWMAAPPEVHSALLSSGPGPGSLLVAAGEWTSLSIT
:*:: ******::** ***...: .. * .*.
Rv3739c|M.tuberculosis_H37Rv YASAAQELTAVLAAVQGGAWEGPSAEAYVAAHLPYLA-------------
Mb3047c|M.bovis_AF2122/97 YAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAV_4349|M.avium_104 YASAAEELSGLLASAQAGAWQGPSAASYVAAHGPYLAWLTRASAHSAAAA
MUL_1202|M.ulcerans_Agy99 YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
MMAR_2944|M.marinum_M YAEAAEELAALLAAVQAGAWDGPTAEIYVAAHVPYLMWLIQASANSAAMA
*: * ** .:: . . *.* :: :* *: **:
Rv3739c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 GEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAV_4349|M.avium_104 AQHETAGTAYTAALAAMPTLPELAANHAVHGALVATNFFGINTIPIAVNE
MUL_1202|M.ulcerans_Agy99 AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
MMAR_2944|M.marinum_M GQQQTAAAAYTAALAAMPTLAELGANHTIHTGLVVTNFFGINTIPIAVNE
Rv3739c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 ADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR--A
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR--A
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS--A
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD--A
MAV_4349|M.avium_104 ADYARMWVQAAGTMATYQAVSTAAVAAVPQPDPAPSILRST-AAHDHDDH
MUL_1202|M.ulcerans_Agy99 ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAP-AAAHDHDH
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHDHDHGHDDHDH
MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQP
MMAR_2944|M.marinum_M ADYVRMWIQAAAVMGGYQDVSATAVAAAPQPAPAPPIMNAAAPAAAAAQA
Rv3739c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 AATITP---------------------------------FPFGELAKFLE
Mflv_0325|M.gilvum_PYR-GCK AADMSA---------------------------------FAAQPMAAQAG
Mvan_0415|M.vanbaalenii_PYR-1 AADVTA---------------------------------FAAQAQAAEAG
MSMEG_0619|M.smegmatis_MC2_155 SASVQQ---------------------------------MSAQATAAESG
TH_3569|M.thermoresistible__bu MATTQQ---------------------------------IGSQATAADSG
MAV_4349|M.avium_104 EHGDDHDHDHGF---------------------DSPLNQFVAQILRLFG-
MUL_1202|M.ulcerans_Agy99 DHGGDP----------------------------TPIDYFVAEVLRIISG
MAB_0809c|M.abscessus_ATCC_199 EHGHDD--------------------------------------------
MLBr_01828|M.leprae_Br4923 SPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSG
MMAR_2944|M.marinum_M AELPPDR--QSQ-FLQWLKDIGYVDLYNKLIKPFVDWLANIPFLQALFSG
Rv3739c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 MAAQAFTEVGELIMKSAEAWAVGFVELITGLVNFEPWLVLTGMIDMFFAT
Mflv_0325|M.gilvum_PYR-GCK AAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR--DPIGNTFALITDFLTN
Mvan_0415|M.vanbaalenii_PYR-1 SALDLSNIIADLIRAYGELLRFLFEPIFDFLR--DPLGNTIKLITDFLTN
MSMEG_0619|M.smegmatis_MC2_155 SSLDLSSIISDLLNQYLQGVPGGQ-AILDFLK--DPLGNLGRLLTDFMTN
TH_3569|M.thermoresistible__bu TALNLSDLIANLLQYYQDYLDQLFGPIVDFLR--DPIGNLFQLIDDFLTN
MAV_4349|M.avium_104 --IDWDPVEGTLNGLPYEAYTSPADPLWWVVRALELFSDFQQFGALLQEN
MUL_1202|M.ulcerans_Agy99 GRIIWDPAEGTVNGIPYDDYVNAAQPIWWLVRALEFGQDFQTFIKELFTN
MAB_0809c|M.abscessus_ATCC_199 -----DHGHGDLD---------PTDPEWWVHVAGEMVEHFELLLNNLLTD
MLBr_01828|M.leprae_Br4923 FDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLAA
MMAR_2944|M.marinum_M FDPYLLTLGNPLTYLSPLNIAFALGYPMDFATYVTLLSQTFAFIGADLAA
Rv3739c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 VGFALGVFVLVPLLEFAVVLEL-------AILSIGWIISNIFGAIPVLAG
Mflv_0325|M.gilvum_PYR-GCK P--VQALITWGPFL-LAVVYQA-------VSWVGASILYPSLFLLPLLAT
Mvan_0415|M.vanbaalenii_PYR-1 P--AQALITWGPFL-AAVAYQA-------VSWVGASILYPSLLLLPLVAT
MSMEG_0619|M.smegmatis_MC2_155 P--AGALATWWPFL-FGVAYQV-------FFNLVGWPTWGMIFASPFLIP
TH_3569|M.thermoresistible__bu P--AGALVTWWPLL-FAVAYQV-------FTNLVGWPTWAMILASPVLIP
MAV_4349|M.avium_104 PAAAFQFITELVLLDWPTHLAQ-------LASWLPT-QPQLLLVPALVAA
MUL_1202|M.ulcerans_Agy99 PIGAIEFMVELVLFDWPTHIAQ-------IIQALAQ-SPQLLAVALGGVV
MAB_0809c|M.abscessus_ATCC_199 PAALLTNLP-MVLADVAFHAAQ-------LASTIGQFAPALIQPALALAI
MLBr_01828|M.leprae_Br4923 AFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMILPL
MMAR_2944|M.marinum_M AFASGNPMTIGLTILFTSVEAIGTIITDTIALLKTLLEQTAVLLAALAPM
Rv3739c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 PLLGALA--AAVVPGVAGVTG----LAGLAAVPAVGAAAG----------
Mflv_0325|M.gilvum_PYR-GCK TLAIVAG--VGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATM
Mvan_0415|M.vanbaalenii_PYR-1 TLAIVLG--VGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAV
MSMEG_0619|M.smegmatis_MC2_155 ALAALGI--TGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGI
TH_3569|M.thermoresistible__bu LAITLGV--AGLVMIADQAQP-----PAEEAAPEEDVAAP----------
MAV_4349|M.avium_104 APFGALAGFAGVAGQ-PPLPAPVAEPATPSAAAPTGLPATAGATPIAASA
MUL_1202|M.ulcerans_Agy99 ANLGAISGLAGLSGL-AGLHS-AALPAAIAPIAPPMPPGVALAPTVAASV
MAB_0809c|M.abscessus_ATCC_199 ANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPMAASAGTALAPSPPASA
MLBr_01828|M.leprae_Br4923 LTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVPPSM
MMAR_2944|M.marinum_M LAAPLVPLAAGAVLVPLGAKGLAALVAVPPPALPVAAPAAPPVALTP---
Rv3739c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 -----------APAALVGSVAPVSGGVVSPQARLV---------------
Mflv_0325|M.gilvum_PYR-GCK SAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAG---------
Mvan_0415|M.vanbaalenii_PYR-1 SAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAG---------
MSMEG_0619|M.smegmatis_MC2_155 SPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVAN---------
TH_3569|M.thermoresistible__bu ---------VRAEPQNPLPLTXXX--------------------------
MAV_4349|M.avium_104 AASVPAPTPAPTAATVSSPAPPAPPAPGAAPFAPPYAVPP----------
MUL_1202|M.ulcerans_Agy99 AAPTPPSAPPSAASTVANAAPPPPPAPAAAGFGFPFVVGGG---------
MAB_0809c|M.abscessus_ATCC_199 AAPAAPASAPAPTASGTAPAPPSPPPVGDPGFSFPYAVGGG---------
MLBr_01828|M.leprae_Br4923 PTLASIPTPTPMPAPA-ASTAPVVTPPGPPPVTAPPSVTGA----GVESF
MMAR_2944|M.marinum_M ----NVPPTPPAPAPVDASTLTLTQAPPPPPSTAPPPVSGAGLGVGMENF
Rv3739c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 ---------------SAVEPA---PASTS---------------------
Mflv_0325|M.gilvum_PYR-GCK RDPYEGFSPTVRDSTGAKAPAGTIPAAASGI---AASAAERRKRRRRQKE
Mvan_0415|M.vanbaalenii_PYR-1 RDPGTGFSPTVRDSTSAKAPASGIPAAASGV---AASAAERRKRRRRQKD
MSMEG_0619|M.smegmatis_MC2_155 RDPGEGFTPTLGNKSQVAAPASGVPAAASGV---AASLASRRKRRRKKGA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_4349|M.avium_104 PGVGFGSKARASVD--TRAKSKSPQPDSNAV---GAGSAVREAAHARRRQ
MUL_1202|M.ulcerans_Agy99 PGIGYGEGMSASAA--ASARRKAPEPDSAAL---AAAAAVREEARRRRRK
MAB_0809c|M.abscessus_ATCC_199 PRLGTGLALAAQVRRGTSAAARSSAREQAAA---AETAAARQARRRRDKG
MLBr_01828|M.leprae_Br4923 GYLVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRA
MMAR_2944|M.marinum_M GYMVGGLGADAKSAARASARKKAPRPDGAEVPVVAPAPSEPARSQRRRRT
Rv3739c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 ---------------------------VSVLASDRG--AGALGFVGTAGK
Mflv_0325|M.gilvum_PYR-GCK EIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRG--AGPMGFAGTVSR
Mvan_0415|M.vanbaalenii_PYR-1 EIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERG--AGPMGFAGTVSR
MSMEG_0619|M.smegmatis_MC2_155 QIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERG--SDAMGFTGTVTR
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_4349|M.avium_104 RSRRR--GEEFMDMNVGVDPDWDEPAT---TASPRG--AGNLGFAGTAPR
MUL_1202|M.ulcerans_Agy99 RKTERGYGEEFMDVEV--DPDWGGPLDDEPVASTQG--AGRLGFAGTVHS
MAB_0809c|M.abscessus_ATCC_199 KQQGR--GIEYMDMNATARCEEPAPDT---TASHRG--AGTMGFAGTVIK
MLBr_01828|M.leprae_Br4923 KVTPFD---------SSGSPNPKAAP----TASDQG--AGTLGLAGTARQ
MMAR_2944|M.marinum_M KVGQLGRGFEYMDLESETAPDSMTGSERITTASGLAGSAGTFGFSGVAGK
Rv3739c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 ESVGQPAGLTVLA--DEFGDGAPVPMLPGSWGPD---------LVGVAGD
Mflv_0325|M.gilvum_PYR-GCK GDE-QAGGLTTLAG-DSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGH
Mvan_0415|M.vanbaalenii_PYR-1 DAA-QAGGLTTLPG-DPFGGGPKAPMLPGTWDPDTEPD------ERHNHH
MSMEG_0619|M.smegmatis_MC2_155 HDV-TAAGLTTLTG-DTFDDRPVTPMLPGTWDGDENPA------PSPDDP
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_4349|M.avium_104 ETVA-AAGMTQLAG-DEFGGGAGMPLLPGSWAPP------------DPRD
MUL_1202|M.ulcerans_Agy99 ESAATAAGLTTLVA-DEFGGGPKMPMLPGTWDTD------------SDAP
MAB_0809c|M.abscessus_ATCC_199 TGAT-ASGLAMLSRDDDLFEGVRAPMVPNTWDPE------------HGRQ
MLBr_01828|M.leprae_Br4923 ASSGPATGLVTLSN-GTFSDSPRAPMLPRTWGADPTFCYNAADIGPAGGW
MMAR_2944|M.marinum_M SGDRTAAGLIKLAG-DGYDDGPRTPAMPSTWDGDPAPSPD----------
Rv3739c|M.tuberculosis_H37Rv ------
Mb3047c|M.bovis_AF2122/97 GGLVSV
Mflv_0325|M.gilvum_PYR-GCK DGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 DGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 EGGPRR
TH_3569|M.thermoresistible__bu ------
MAV_4349|M.avium_104 SGV---
MUL_1202|M.ulcerans_Agy99 SD----
MAB_0809c|M.abscessus_ATCC_199 D-----
MLBr_01828|M.leprae_Br4923 DDE---
MMAR_2944|M.marinum_M ------