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TAPIWMAAPPEVHSALLSSGPGPGSLLVAAGEWTSLSITYAEAAEELAALLAAVQAGAWDGPTAEIYVAA HVPYLMWLIQASANSAAMAGQQQTAAAAYTAALAAMPTLAELGANHTIHTGLVVTNFFGINTIPIAVNEA DYVRMWIQAAAVMGGYQDVSATAVAAAPQPAPAPPIMNAAAPAAAAAQAAELPPDRQSQFLQWLKDIGYV DLYNKLIKPFVDWLANIPFLQALFSGFDPYLLTLGNPLTYLSPLNIAFALGYPMDFATYVTLLSQTFAFI GADLAAAFASGNPMTIGLTILFTSVEAIGTIITDTIALLKTLLEQTAVLLAALAPMLAAPLVPLAAGAVL VPLGAKGLAALVAVPPPALPVAAPAAPPVALTPNVPPTPPAPAPVDASTLTLTQAPPPPPSTAPPPVSGA GLGVGMENFGYMVGGLGADAKSAARASARKKAPRPDGAEVPVVAPAPSEPARSQRRRRTKVGQLGRGFEY MDLESETAPDSMTGSERITTASGLAGSAGTFGFSGVAGKSGDRTAAGLIKLAGDGYDDGPRTPAMPSTWD GDPAPSPD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2944 | - | - | 100% (569) | PPE family protein |
| M. marinum M | MMAR_0538 | - | 6e-98 | 41.48% (581) | PPE family protein, PPE3 |
| M. marinum M | MMAR_1418 | - | 5e-95 | 41.65% (581) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0262c | PPE2 | 0.0 | 62.54% (574) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 5e-84 | 37.71% (586) | PPE protein |
| M. tuberculosis H37Rv | Rv0256c | PPE2 | 0.0 | 62.54% (574) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 1e-158 | 52.26% (574) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 6e-84 | 38.20% (568) | PPE family protein |
| M. avium 104 | MAV_1329 | - | 1e-175 | 56.64% (565) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 7e-91 | 41.24% (582) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 6e-69 | 53.90% (269) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1202 | - | 5e-96 | 41.25% (577) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-82 | 37.86% (589) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0262c|M.bovis_AF2122/97 ----------MTAPIWMASPPEVHSALLSSGPGPGPLLVSAEGWHSLSIA
Rv0256c|M.tuberculosis_H37Rv ----------MTAPIWMASPPEVHSALLSSGPGPGPLLVSAEGWHSLSIA
MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
MMAR_2944|M.marinum_M ----------MTAPIWMAAPPEVHSALLSSGPGPGSLLVAAGEWTSLSIT
MAV_1329|M.avium_104 -------MRSMTAPIWMASPPEVHSSLLSAGPGPGPLLAAAAAWSSLSVQ
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
MUL_1202|M.ulcerans_Agy99 --------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
:*:: ******::** ***...:: .. * .**
Mb0262c|M.bovis_AF2122/97 YAETADELAALLAAVQAGTWDGPTAAVYVAAHTPYLAWLVQASANSAAMA
Rv0256c|M.tuberculosis_H37Rv YAETADELAALLAAVQAGTWDGPTAAVYVAAHTPYLAWLVQASANSAAMA
MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
MMAR_2944|M.marinum_M YAEAAEELAALLAAVQAGAWDGPTAEIYVAAHVPYLMWLIQASANSAAMA
MAV_1329|M.avium_104 YAESADELVTLLGAVRAGDWDGPTAGAYLAAHAPYLAWLVRASTDSAAVA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
MUL_1202|M.ulcerans_Agy99 YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
*: * ** * * . *:* :: * *: *** ** . *. .* *
Mb0262c|M.bovis_AF2122/97 TRQETAATAYGTALAAMPTLAELGANHALHGVLMATNFFGINTIPIALNE
Rv0256c|M.tuberculosis_H37Rv TRQETAATAYGTALAAMPTLAELGANHALHGVLMATNFFGINTIPIALNE
MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
MMAR_2944|M.marinum_M GQQQTAAAAYTAALAAMPTLAELGANHTIHTGLVVTNFFGINTIPIAVNE
MAV_1329|M.avium_104 AQQEVAAAAYTAALAAMPTLPELAANHAAHAVLTATNFFGVNTIPIAVNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
MUL_1202|M.ulcerans_Agy99 AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
: :. *:** :** ***: ** *:. * * ***:*:****** .*
Mb0262c|M.bovis_AF2122/97 SDYARMWIQAATTMASYQAVSTAAVAAAPQTTPAPQIVKANAPTAASDEP
Rv0256c|M.tuberculosis_H37Rv SDYARMWIQAATTMASYQAVSTAAVAAAPQTTPAPQIVKANAPTAASDEP
MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQP
MMAR_2944|M.marinum_M ADYVRMWIQAAAVMGGYQDVSATAVAAAPQPAPAPPIMNAAAPAAAAAQA
MAV_1329|M.avium_104 ADYARMWVQAATVMGTYQDVAAAALAATPHTEPAPRVMAAAAPAATAAQS
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVG-------
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVG-------
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVG-------
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVS-------
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSG-------
MUL_1202|M.ulcerans_Agy99 ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAAHD----
** ***::** *. ** *: : ::* . .** :: .
Mb0262c|M.bovis_AF2122/97 N--------QVQEWLQWLQKIGYTDFYNNVIQPFINWLTNLPFLQAMFSG
Rv0256c|M.tuberculosis_H37Rv N--------QVQEWLQWLQKIGYTDFYNNVIQPFINWLTNLPFLQAMFSG
MLBr_01828|M.leprae_Br4923 SPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSG
MMAR_2944|M.marinum_M AELPPD---RQSQFLQWLKDIGYVDLYNKLIKPFVDWLANIPFLQALFSG
MAV_1329|M.avium_104 SSYPPD---TQDQWLDWLEKTGFVDFYNRYIQPLIDQLMNNPFFQSLFSG
Mflv_0325|M.gilvum_PYR-GCK ---------------------------------------------EAGRA
Mvan_0415|M.vanbaalenii_PYR-1 ---------------------------------------------EAGRA
MSMEG_0619|M.smegmatis_MC2_155 ---------------------------------------------EAGSA
TH_3569|M.thermoresistible__bu ---------------------------------------------EAADA
MAB_4783|M.abscessus_ATCC_1997 ---------------------------------------------AAART
MUL_1202|M.ulcerans_Agy99 ------------------------------------------HDHDHGGD
Mb0262c|M.bovis_AF2122/97 FDPWLPSLGNPLTFLSPANIAFALGYPMDIGSYVAFLSQTFAFIGADLAA
Rv0256c|M.tuberculosis_H37Rv FDPWLPSLGNPLTFLSPANIAFALGYPMDIGSYVAFLSQTFAFIGADLAA
MLBr_01828|M.leprae_Br4923 FDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLAA
MMAR_2944|M.marinum_M FDPYLLTLGNPLTYLSPLNIAFALGYPMDFATYVTLLSQTFAFIGADLAA
MAV_1329|M.avium_104 FDPWLPSLGNPLSFLNPFNIAFALGYPMDFGSYFGYLAQMFSFVAADLAA
Mflv_0325|M.gilvum_PYR-GCK AADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRD
Mvan_0415|M.vanbaalenii_PYR-1 AADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRD
MSMEG_0619|M.smegmatis_MC2_155 SASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKD
TH_3569|M.thermoresistible__bu MATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRD
MAB_4783|M.abscessus_ATCC_1997 AA-------QDATKPPPIVPDPNDPIEMLLKNSQHFL-GMYRALKGLITD
MUL_1202|M.ulcerans_Agy99 PTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIPYDDYVNAAQPIWWLVRA
: : :
Mb0262c|M.bovis_AF2122/97 AFASGNPATIAFTLMFTTVEAIGTIITDTIALVKTLLEQTLALLPAALPL
Rv0256c|M.tuberculosis_H37Rv AFASGNPATIAFTLMFTTVEAIGTIITDTIALVKTLLEQTLALLPAALPL
MLBr_01828|M.leprae_Br4923 AFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMILPL
MMAR_2944|M.marinum_M AFASGNPMTIGLTILFTSVEAIGTIITDTIALLKTLLEQTAVLLAALAPM
MAV_1329|M.avium_104 AFASGNPATIAWTLLFTTIEVIGTVITDTIALIKTLLEQMIVLIPAILPL
Mflv_0325|M.gilvum_PYR-GCK PIG--NTFALITDFLTNPVQALITWGP-FLLAVVYQAVSWVGASILYPSL
Mvan_0415|M.vanbaalenii_PYR-1 PLG--NTIKLITDFLTNPAQALITWGP-FLAAVAYQAVSWVGASILYPSL
MSMEG_0619|M.smegmatis_MC2_155 PLG--NLGRLLTDFMTNPAGALATWWP-FLFGVAYQVFFNLVGWPTWGMI
TH_3569|M.thermoresistible__bu PIG--NLFQLIDDFLTNPAGALVTWWP-LLFAVAYQVFTNLVGWPTWAMI
MAB_4783|M.abscessus_ATCC_1997 PVG--TIVRIIIDFSTNPAAAIVTWTP-LFYVFAYAATFAVMGTPIYAAI
MUL_1202|M.ulcerans_Agy99 LEFGQDFQTFIKELFTNPIGAIEFMVELVLFDWPTHIAQIIQALAQSPQL
: : .. .: : :
Mb0262c|M.bovis_AF2122/97 LAAPLAPLTLAPASAAGGFAGLSGLAGLVGIPPSAPPVIPPVAAIAPSIP
Rv0256c|M.tuberculosis_H37Rv LAAPLAPLTLAPASAAGGFAGLSGLAGLVGIPPSAPPVIPPVAAIAPSIP
MLBr_01828|M.leprae_Br4923 LTAPLA---VATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVP
MMAR_2944|M.marinum_M LAAPLVP---LAAGAVLVPLGAKGLAALVAVPPPALPVAAPAAPPVALTP
MAV_1329|M.avium_104 LTVSVVP--LVVPTLVGGLAGLTGLAGLHAIPVPPFVPAPTLVPVALAPS
Mflv_0325|M.gilvum_PYR-GCK FLLPLL----ATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSR
Mvan_0415|M.vanbaalenii_PYR-1 LLLPLV----ATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTR
MSMEG_0619|M.smegmatis_MC2_155 FASPFL----IPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP
TH_3569|M.thermoresistible__bu LASPVL----IPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP
MAB_4783|M.abscessus_ATCC_1997 MGP-------AAGISIPLAITLASLSQMPEAPPVDAPAETVPARIDQPHA
MUL_1202|M.ulcerans_Agy99 LAVALG----GVVANLGAISGLAGLSGLAGLHSAALPAAIAPIAPPMPPG
: :
Mb0262c|M.bovis_AF2122/97 ------TPTPTPAPAPAPTAVTAPTPPPGPPPPPVTAPPPVTGA----GI
Rv0256c|M.tuberculosis_H37Rv ------TPTPTPAPAPAPTAVTAPTPPPGPPPPPVTAPPPVTGA----GI
MLBr_01828|M.leprae_Br4923 PSMPTLASIPTPTPMPAPAASTAPVVTP-PGPPPVTAPPSVTGA----GV
MMAR_2944|M.marinum_M -------NVPPTPPAPAPVDASTLTLTQAPPPPPSTAPPPVSGAGLGVGM
MAV_1329|M.avium_104 -------PPPAPAPAPSPAPAPAPTSAAAPAAAAPGAPPPTPSGPPVATL
Mflv_0325|M.gilvum_PYR-GCK PDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATF------
Mvan_0415|M.vanbaalenii_PYR-1 ADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASF------
MSMEG_0619|M.smegmatis_MC2_155 RTDQPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATF------
TH_3569|M.thermoresistible__bu -------------------VRAEPQNPLPLTXXX----------------
MAB_4783|M.abscessus_ATCC_1997 VAMGGAPAPTASTAAP--TPTTTSPATPGSAPAP-TPPPAGAEG------
MUL_1202|M.ulcerans_Agy99 VALAPTVAASVAAPTPPSAPPSAASTVANAAPPPPPAPAAAGFG------
.
Mb0262c|M.bovis_AF2122/97 QSFGYLVGDLNSAAQARKAVGTGVRKK-TPEPDSAEAPAAAAAPEEQVQP
Rv0256c|M.tuberculosis_H37Rv QSFGYLVGDLNSAAQARKAVGTGVRKK-TPEPDSAEAPAAAAAPEEQVQP
MLBr_01828|M.leprae_Br4923 ESFGYLVGRLPSTARG--VVGTSVRQQ-SSAPDRIEAPDAAATPQEQARS
MMAR_2944|M.marinum_M ENFGYMVGGLGADAKS--AARASARKK-APRPDGAEVPVVAPAPSEPARS
MAV_1329|M.avium_104 HSLAYLVGGLTADARR--AANAGVRRREAAAPENVEAPAVAQ-PEEESTQ
Mflv_0325|M.gilvum_PYR-GCK --VPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKR
Mvan_0415|M.vanbaalenii_PYR-1 --VPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKR
MSMEG_0619|M.smegmatis_MC2_155 --VPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKR
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 --LGYAVRGDGPGFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKS
MUL_1202|M.ulcerans_Agy99 --FPFVVGG-GPGIGYGEGMSASAAASARRKAPEPDSAALAAAAAVREEA
Mb0262c|M.bovis_AF2122/97 QRRRRPKIKQLGRGYEYLDLDPETGHDPTGSPQ----------GAGTLGF
Rv0256c|M.tuberculosis_H37Rv QRRRRPKIKQLGRGYEYLDLDPETGHDPTGSPQ----------GAGTLGF
MLBr_01828|M.leprae_Br4923 RWRRRAKVTPFDS-----SGSPNPKAAPTASDQ----------GAGTLGL
MMAR_2944|M.marinum_M QRRRRTKVGQLGRGFEYMDLESETAPDSMTGSERITTASGLAGSAGTFGF
MAV_1329|M.avium_104 RRRHRAAAKQLGRGYEYLDPEPSTTASQL--------------GAPTLGF
Mflv_0325|M.gilvum_PYR-GCK RRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTR--GAGPMGF
Mvan_0415|M.vanbaalenii_PYR-1 RRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATER--GAGPMGF
MSMEG_0619|M.smegmatis_MC2_155 RRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASER--GSDAMGF
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 RRRRRRTIDDRGYRHEYATMDDHTPTGP--QDPVTAVASGT--GAGRLGF
MUL_1202|M.ulcerans_Agy99 RRRRRKRKTERGYGEEFMDVEVDPDWGGPLDDEP--VASTQ--GAGRLGF
Mb0262c|M.bovis_AF2122/97 AGTTHKASPGQVAGLITLPNDAFGGSPRTPMMPGTWDTDSATRVE-----
Rv0256c|M.tuberculosis_H37Rv AGTTHKASPGQVAGLITLPNDAFGGSPRTPMMPGTWDTDSATRVE-----
MLBr_01828|M.leprae_Br4923 AGTARQASSGPATGLVTLSNGTFSDSPRAPMLPRTWGADPTFCYNAADIG
MMAR_2944|M.marinum_M SGVAGKSGDRTAAGLIKLAGDGYDDGPRTPAMPSTWDGDPAPSPD-----
MAV_1329|M.avium_104 AGTAANRAAAAPAGLSAPVLDEFADAPRAPMMPATWDGSKQ---------
Mflv_0325|M.gilvum_PYR-GCK AGT-VSRGDEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRD
Mvan_0415|M.vanbaalenii_PYR-1 AGT-VSRDAAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------E
MSMEG_0619|M.smegmatis_MC2_155 TGT-VTRHDVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPA------P
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 AGVHTATTAVEATGLSTLDGDAEN--RTIPMLPGTWDVTDDDR-------
MUL_1202|M.ulcerans_Agy99 AGTVHSESAATAAGLTTLVADEFGGGPKMPMLPGTWDTDSDAPSD-----
Mb0262c|M.bovis_AF2122/97 -----------
Rv0256c|M.tuberculosis_H37Rv -----------
MLBr_01828|M.leprae_Br4923 PAGGWDDE---
MMAR_2944|M.marinum_M -----------
MAV_1329|M.avium_104 -----------
Mflv_0325|M.gilvum_PYR-GCK GHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 RHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 SPDDPEGGPRR
TH_3569|M.thermoresistible__bu -----------
MAB_4783|M.abscessus_ATCC_1997 -----------
MUL_1202|M.ulcerans_Agy99 -----------