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TAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAA YVPYVAWLVQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3022c | PPE48 | - | 100% (81) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 3e-42 | 100.00% (81) | PPE family protein |
| M. tuberculosis H37Rv | Rv3739c | PPE67 | 8e-30 | 72.73% (77) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 8e-42 | 98.77% (81) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-27 | 60.49% (81) | PPE protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 1e-22 | 54.32% (81) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 1e-28 | 65.43% (81) | PPE family protein |
| M. marinum M | MMAR_0491 | - | 7e-29 | 66.67% (81) | PPE family protein |
| M. avium 104 | MAV_4349 | - | 1e-28 | 66.67% (81) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-28 | 65.43% (81) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 6e-30 | 70.37% (81) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 7e-29 | 71.79% (78) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 7e-29 | 66.67% (81) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3022c|M.tuberculosis_H37Rv ----------VTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAE
Mb3047c|M.bovis_AF2122/97 ----------MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_2230c|M.abscessus_ATCC_199 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQ
MUL_1208|M.ulcerans_Agy99 -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MAV_4349|M.avium_104 ----MTTVPAMTAPIWMASPPEVHSALLSSGPGPASVFAAAAAWSALGAE
MMAR_0491|M.marinum_M ----------MTAPLWMASAPEVHSALLSAGPGPGSLLAAAQTWTELSAE
MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
:.*:*:* .*****::** ***...: .*. * *.
Rv3022c|M.tuberculosis_H37Rv YAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQ---------
Mb3047c|M.bovis_AF2122/97 YAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_2230c|M.abscessus_ATCC_199 YTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNA
MUL_1208|M.ulcerans_Agy99 YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MAV_4349|M.avium_104 YASAAEELSGLLASAQAGAWQGPSAASYVAAHGPYLAWLTRASAHSAAAA
MMAR_0491|M.marinum_M YLAVAEELTAILTGVQAGAWDGPSAQCCIAAYVPYLSWLMQASADSAATA
MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
* * ** :: . . *:*.:. : :: **: ** :
Rv3022c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 GEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_2230c|M.abscessus_ATCC_199 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
MUL_1208|M.ulcerans_Agy99 AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MAV_4349|M.avium_104 AQHETAGTAYTAALAAMPTLPELAANHAVHGALVATNFFGINTIPIAVNE
MMAR_0491|M.marinum_M AAHQAAATAYTGALAAMPTLGELAANHATHAVLVATNFFGLNTIPIALNE
MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
Rv3022c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 ADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIV-KPGANEASNAV
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVL-LPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVL-APGVGEAGRAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLL-KPGVGEAGSAS
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLL-APGVSEAADAM
MAB_2230c|M.abscessus_ATCC_199 ADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIM-APG-GEMSRMS
MUL_1208|M.ulcerans_Agy99 ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVV-NPGGGQVAHLA
MAV_4349|M.avium_104 ADYARMWVQAAGTMATYQAVSTAAVAAVPQPDPAPSILRSTAAHDHDDHE
MMAR_0491|M.marinum_M VDYVRMWIQAATTMSVYQAVAADALLAVPRTPPAPVII-KPGADAAAQFA
MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQP
Rv3022c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 AAAT--ITPFPFGELAKFLEMAAQAFT-----------------------
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVS-NIIADIIRL----------YGEVLRFL
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLS-NIIADLIRA----------YGELLRFL
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSLDLS-SIISDLLNQ----------YLQGVPGG
TH_3569|M.thermoresistible__bu ATTQQIGSQATAADSGTALNLS-DLIANLLQY----------YQDYLDQL
MAB_2230c|M.abscessus_ATCC_199 ADMSGMAAQAQAAESGMALDDS-ESFFDKLMR------------------
MUL_1208|M.ulcerans_Agy99 ADAARAQSGAAAAGGSDPWQLLWQLLQYLWNA----------YTGFNTWM
MAV_4349|M.avium_104 HGDDHDHDHGFDSPLNQFVAQILRLFGIDWDP----------VEGTLNGL
MMAR_0491|M.marinum_M SAVVQAVAETPIQR--LLLELATLVGAEFIN-------------------
MLBr_01828|M.leprae_Br4923 SPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSG
Rv3022c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 --EVGELIMKSAEAWAVGFV---------------------ELIT----G
Mflv_0325|M.gilvum_PYR-GCK FEPIFNFLRDPIGNTFALIT---------------------DFLTNPVQA
Mvan_0415|M.vanbaalenii_PYR-1 FEPIFDFLRDPLGNTIKLIT---------------------DFLTNPAQA
MSMEG_0619|M.smegmatis_MC2_155 Q-AILDFLKDPLGNLGRLLT---------------------DFMTNPAGA
TH_3569|M.thermoresistible__bu FGPIVDFLRDPIGNLFQLID---------------------DFLTNPAGA
MAB_2230c|M.abscessus_ATCC_199 --QIQEFFSDPLGTLQKILQ---------------------DFMRNPLEA
MUL_1208|M.ulcerans_Agy99 FDLIWEFLQDPIGNTIKIII---------------------AFLTNPLQA
MAV_4349|M.avium_104 PYEAYTSPADPLWWVVRALELFSD------------FQQFGALLQENPAA
MMAR_0491|M.marinum_M ---VFELIVG----IVVLST---------------------YGLKLPLLA
MLBr_01828|M.leprae_Br4923 FDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLAA
Rv3022c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 LVNFEP------WLVLTGMIDMFFATV--GFALGVFVLVPLLEF--AVVL
Mflv_0325|M.gilvum_PYR-GCK LITWGP------FLLAVVYQAVSWVGA--SILYPSLFLLPLLATTLAIVA
Mvan_0415|M.vanbaalenii_PYR-1 LITWGP------FLAAVAYQAVSWVGA--SILYPSLLLLPLVATTLAIVL
MSMEG_0619|M.smegmatis_MC2_155 LATWWP------FLFGVAYQVFFNLVG--WPTWGMIFASPFLIPALAALG
TH_3569|M.thermoresistible__bu LVTWWP------LLFAVAYQVFTNLVG--WPTWAMILASPVLIPLAITLG
MAB_2230c|M.abscessus_ATCC_199 LVAWGP------LLFFIAYEAFFIPFG--FTFWGVMLSAPLWLP----LL
MUL_1208|M.ulcerans_Agy99 IITYGP------LLFALSYQIFFNLVG--WPTWALILSSPFLLP---AAL
MAV_4349|M.avium_104 AFQFIT------ELVLLDWPTHLAQLASWLPTQPQLLLVPALVAAAPFGA
MMAR_0491|M.marinum_M LLDFLT------GHFSVALSLLWNYAM----LWFGFVVLPALQIVFDPLL
MLBr_01828|M.leprae_Br4923 AFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMILPL
Rv3022c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 ELAILSIGWIISNIFGAIPVLAGPLLGALAAAVVP---------------
Mflv_0325|M.gilvum_PYR-GCK GVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSG
Mvan_0415|M.vanbaalenii_PYR-1 GVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSS
MSMEG_0619|M.smegmatis_MC2_155 ITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGS
TH_3569|M.thermoresistible__bu VAGLVMIADQAQP-----PAEEAAPEEDVAAP------------------
MAB_2230c|M.abscessus_ATCC_199 LVGLAQLVN-PVPVEADAPADEPAPQQARVERSSPQQQPFAMGGMPGGGG
MUL_1208|M.ulcerans_Agy99 GLALSAIAFTPIQIAAEVPAAAAPLAAAAVTAKSVFPAASLASPGTGSAG
MAV_4349|M.avium_104 LAGFAGVAGQPPLPAPVAEPATPSAAAPTGLPATAGATPIAASAAASVPA
MMAR_0491|M.marinum_M VV---------------AAVIEWILGGGAALG------------------
MLBr_01828|M.leprae_Br4923 LTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVPPSM
Rv3022c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 -GVAGVTGLAGLAAVPAVGAAAGAP-----AALVGS------VAPVSG--
Mflv_0325|M.gilvum_PYR-GCK APIAANTVSAGSPPAPGAPAAAAAT--FVPYVVAGR-DPYEGFSPTVRDS
Mvan_0415|M.vanbaalenii_PYR-1 AAATVGTVATGTAPAPGAPAAATAS--FVPYAVAGR-DPGTGFSPTVRDS
MSMEG_0619|M.smegmatis_MC2_155 AATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVANR-DPGEGFTPTLGNK
TH_3569|M.thermoresistible__bu -VRAEPQNPLPLTXXX----------------------------------
MAB_2230c|M.abscessus_ATCC_199 APATPANAPATPANAPASPAAAAATPAYMVYAVQED-PPAARFGPTLNEG
MUL_1208|M.ulcerans_Agy99 APASGAGAGAPGTAPPGPGAPAPAS---FLYAVGGSGDWGPSLGPTVGGR
MAV_4349|M.avium_104 PTPAPTAATVSSPAPPAPPAPGAAPFAPPYAVPPPGVGFGSKARASVDTR
MMAR_0491|M.marinum_M ---SVGALGANLAAGLALPAVAAAP-----------------VADAAVGS
MLBr_01828|M.leprae_Br4923 PTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPS-VTGAGVESFGYLV
Rv3022c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 -GVVSPQARLVSAVEPAPASTS----------------------------
Mflv_0325|M.gilvum_PYR-GCK TGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEEL
Mvan_0415|M.vanbaalenii_PYR-1 TSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPE
MSMEG_0619|M.smegmatis_MC2_155 SQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 SGAKAPAAGISAAAA-AAASARSRARRKRGARIKDPAPQFMDMNSPVDP-
MUL_1208|M.ulcerans_Agy99 SGAKAPAVTIPAAGAAAASRASARSRRRRR----TEMRDYGDEFLDMDAN
MAV_4349|M.avium_104 AKSKSPQPDSNAVGAGSAVREAAHARRRQRSR--RRGEEFMDMNVGVDP-
MMAR_0491|M.marinum_M LGVLTSAAAVTAAAAAAPG-------------------------------
MLBr_01828|M.leprae_Br4923 GRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAKVTP
Rv3022c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3047c|M.bovis_AF2122/97 ----------VSVLASDRGAGALGFVGTAGKES-VGQPAGLTV--LADEF
Mflv_0325|M.gilvum_PYR-GCK PDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD--EQAGGLTT-LAGDSF
Mvan_0415|M.vanbaalenii_PYR-1 PDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA--AQAGGLTT-LPGDPF
MSMEG_0619|M.smegmatis_MC2_155 PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD--VTAAGLTT-LTGDTF
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 DFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTSAAGLIEREAASEM
MUL_1208|M.ulcerans_Agy99 GVTGPAATDDAAR-ASERGAGQFGFAGTVSTEA-VLQAAGLTE-LAVDEF
MAV_4349|M.avium_104 ------DWDEPATTASPRGAGNLGFAGTAPRET--VAAAGMTQ-LAGDEF
MMAR_0491|M.marinum_M -----------------QGVGLVGFAATMPNPT-TLPAGGLVTVGGADPC
MLBr_01828|M.leprae_Br4923 FDSSGSPNPKAAPTASDQGAGTLGLAGTARQAS-SGPATGLVT-LSNGTF
Rv3022c|M.tuberculosis_H37Rv -------------------------------------------
Mb3047c|M.bovis_AF2122/97 GDGAPVPMLPGSWGPDL---------VGVAGDGGLVSV-----
Mflv_0325|M.gilvum_PYR-GCK GGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP-----
Mvan_0415|M.vanbaalenii_PYR-1 GGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ-----
MSMEG_0619|M.smegmatis_MC2_155 DDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR-----
TH_3569|M.thermoresistible__bu -------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 DGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPGERGAST
MUL_1208|M.ulcerans_Agy99 GNGPRMPMVPGSWDS-----------PQEGREDGLQSE-----
MAV_4349|M.avium_104 GGGAGMPLLPGSWAP------------PDPRDSGV--------
MMAR_0491|M.marinum_M AG-ARVPMLPASWVALA--------------------------
MLBr_01828|M.leprae_Br4923 SDSPRAPMLPRTWGADPTFCYN---AADIGPAGGWDDE-----