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VLRSLASPAALTDPKRCASVVGVAAFAVRREHAPDALGGPPGLPAPRGFRAAFAAAYAVAYLAGGERRML RLIRRYGPIMTMPILSLGDVAIVSDSALAKEVFTAPTDVLLGGEGVGPAAAIYGSGSMFVQEEPEHLRRR KLLTPPLHGAALDRYVPIIENSTRAAMHTWPVDRPFAMLTVARSLMLDVIVKVIFGVDDPEEVRRLGRPF ERLLNLGVSEQLTVRYALRRLGALRVWPARARANTEIDDVVMALIAQRRADPRLGERHDVLSLLVSARGE SGEQLSDSEIRDDLITLVLAGHETTATTLAWAFDLLLHHPDALRRVRAEAVGGGEAFTTAVINETLRVRP PAPLTARVAAQPLTIGGYRVEAGTRIVVHIIAINRSAEVYEHPHEFRPERFLGTRPQTYAWVPFGGGVKR CLGANFSMRELITVLHVLLREGEFTAVDDEPERIVRRSIMLVPRRGTRVRFRPAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3685c | cyp137 | - | 100% (476) | PROBABLE CYTOCHROME P450 137 CYP137 |
| M. tuberculosis H37Rv | Rv0568 | cyp135B1 | 4e-72 | 35.51% (445) | cytochrome P450 135B1 |
| M. tuberculosis H37Rv | Rv0136 | cyp138 | 1e-69 | 35.21% (443) | cytochrome P450 138 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3710c | cyp137 | 0.0 | 99.79% (476) | cytochrome P450 137 |
| M. gilvum PYR-GCK | Mflv_1104 | - | 5e-66 | 36.79% (405) | cytochrome P450 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-20 | 28.84% (378) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_4693 | - | 2e-70 | 35.81% (444) | cytochrome P450 |
| M. marinum M | MMAR_5175 | cyp137A2 | 0.0 | 83.18% (440) | cytochrome P450 137A2 Cyp137A2 |
| M. avium 104 | MAV_5160 | - | 1e-66 | 34.44% (450) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_1213 | - | 3e-65 | 34.57% (405) | cytochrome P450 monooxygenase |
| M. thermoresistible (build 8) | TH_0136 | - | 1e-145 | 60.23% (440) | PROBABLE CYTOCHROME P450 137 CYP137 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 9e-32 | 28.85% (364) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_0675 | - | 1e-152 | 61.33% (437) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3685c|M.tuberculosis_H37Rv MVLRSLASPAALTDPKRCASVVGVAAFAVRREHAPDALGGPPGLPAPRGF
Mb3710c|M.bovis_AF2122/97 MVLRSLASPAALTDPKRCASVVGVAAFAVRREHAPDALGGPPGLPAPRGF
MMAR_5175|M.marinum_M ---MPASAPSARTPP---------------------ALRRPPGLPAPRRL
TH_0136|M.thermoresistible__bu --------------------------------------VRPPSLPAPAPL
Mvan_0675|M.vanbaalenii_PYR-1 --------------------------------------MRPPSLPAPPPL
MAB_4693|M.abscessus_ATCC_1997 --------------------------------------MSKTAKIALPPG
MSMEG_1213|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1104|M.gilvum_PYR-GCK --------------------------------------------MRLPPT
MAV_5160|M.avium_104 ---------------------------------MSEVATAPLAAVHLPPA
MUL_0604|M.ulcerans_Agy99 -------------------------------------MVDPPDIRSLPLA
MLBr_02088|M.leprae_Br4923 ------------------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLV
Rv3685c|M.tuberculosis_H37Rv RAAFAAAYAVAYLAGGERR-MLRLIRRYG----PIMTMPILSLGDVAIVS
Mb3710c|M.bovis_AF2122/97 RAAFAAAYAVAYLAGGERR-MLRLIRRYG----PIMTMPILSLGDVAIVS
MMAR_5175|M.marinum_M RTVFAAAYAVAYLVGGERR-MLRLIRRYG----PIMTMPILSLGDVAIVS
TH_0136|M.thermoresistible__bu SAVFGAGYAAAYAVGGNRM-VARMLKRYG----PVVALPVLGYGTVVAVA
Mvan_0675|M.vanbaalenii_PYR-1 APVFGGLYAAAFGMGGQAI-VAQMVRRYG----PVVALPVLGFGKVVAVA
MAB_4693|M.abscessus_ATCC_1997 PPLPLAVQSILMASYGLRF-LAGCQRRYG----NMFTLRIPLSGKVVYLA
MSMEG_1213|M.smegmatis_MC2_155 ------MQTAMMLRHWSRF-VSACRRRYG----DVFTLRIASMGTWVYLA
Mflv_1104|M.gilvum_PYR-GCK PRIPRFLQGLGFSLSRQWT-VAQVVRRYG----DVFTMTLPVFGKTVLVT
MAV_5160|M.avium_104 VRGPKLLQGIGFAVSRRTM-MRRLSRRYG----NVFTLRLPMWGPVVMVS
MUL_0604|M.ulcerans_Agy99 PRNPLPYWQQLKALKTLHV-GSEALRDAGGSVTRIWLGPKRLVPPMVMVT
MLBr_02088|M.leprae_Br4923 EAQMLLLRLIDPGTRADPFPVYRALIDYG--PMQLPGMPLTVFSSFSDCD
* :
Rv3685c|M.tuberculosis_H37Rv DSALAKEVFTAPTDVLLGGEG--VGPAAAIYGSGSMFVQEEPEHLRRRKL
Mb3710c|M.bovis_AF2122/97 DSALAKEVFTAPTDVLLGGEG--VGPAAAIYGSGSMFVQEEPQHLRRRKL
MMAR_5175|M.marinum_M DPALVKEVFTAPPDVLLGGEG--VGPAAAIYGAGSMFVQEEPEHLRRRKL
TH_0136|M.thermoresistible__bu DPALARQVFAEKPDVLLGGDG--VGPAAAIYGPRSMFVQEEPEHLRRRRL
Mvan_0675|M.vanbaalenii_PYR-1 DAALAKQVFTENPDVLLGGEG--VGPAAAIYGPRSMFVLEEPGHLRRRRL
MAB_4693|M.abscessus_ATCC_1997 DPADIKTVYAGDPHVFHSGEA--HWFFRGLLGDSSLFVLDEDEHHHQRRL
MSMEG_1213|M.smegmatis_MC2_155 DPADIKTVFAGDPTVFHAGEA--NSMLSGLLGETSVLVIDEDVHRDRRRL
Mflv_1104|M.gilvum_PYR-GCK DPALAKQLFMANTD--DVGNI--QPNLSRVLGSGSVFALDGTDHRLRRKL
MAV_5160|M.avium_104 DPQLAKQIFTTSPD--ELGNI--QPNLSRLFGSGSVFGLEGDDHRRRRRL
MUL_0604|M.ulcerans_Agy99 SPQGARDVLGRSGALSDRGTLPLLKDLRRAIG-ESVLNLPHDTWLPRRRT
MLBr_02088|M.leprae_Br4923 EALRHPLSASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKL
.. *.: *:
Rv3685c|M.tuberculosis_H37Rv LTPPLHGAALDRYVPIIENSTRAAMHTWPVDRPFAMLTVARSLMLDVIVK
Mb3710c|M.bovis_AF2122/97 LTPPLHGAALDRYVPIIENSTRAAMHTWPVDRPFAMLTVARSLMLDVIVK
MMAR_5175|M.marinum_M LTPPLHGTALGRYVPIIEESTRAAMRDWPVDRPFELLGAARALMLDVIVK
TH_0136|M.thermoresistible__bu LIPPLHGAALAGHVPVIEAATRSAMASWPVGRPMRMLDAARDLTLDVIIR
Mvan_0675|M.vanbaalenii_PYR-1 LTPPLHGELLGSYVPIIESSTRSAMATWPVGRPMRMLDAARELTLDVIVQ
MAB_4693|M.abscessus_ATCC_1997 LMPAFHRDAVARQATQMAQIAAANIAEWPVGESFPVAPRTTDITLEVILR
MSMEG_1213|M.smegmatis_MC2_155 MLAPFARDAVARQTGVMAEVAATNIASWPVGTPFPVAPKMAEIALEVILR
Mflv_1104|M.gilvum_PYR-GCK LTPPFHGKSIKNYERIFEEETLREAASWPEGQPFETLEPMMRITLNAILR
MAV_5160|M.avium_104 LAPPFHGKSMKNYESIIEEETLRETAGWPEGESFPTLPPMMRITLNAILR
MUL_0604|M.ulcerans_Agy99 LQPIFTKQRVAGFAGHMSEAANHILLGWPDGAEVDLNAASHALVLRVVGH
MLBr_02088|M.leprae_Br4923 VSKAFAPKVVQALEGDIAALVDSLLDKGAAAG-----------QFDVIAD
: : : : . . : .:
Rv3685c|M.tuberculosis_H37Rv VIFGVDDPEEVRRLGRPFERLLNLGVSEQLTVRYALRRLGALRVWPARAR
Mb3710c|M.bovis_AF2122/97 VIFGVDDPEEVRRLGRPFERLLNLGVSEQLTVRYALRRLGALRVWPARAR
MMAR_5175|M.marinum_M VIFGVDDPDEVRRLGRPFERLLDLGVSEQLTVRYALRRAGALRVWPQRAR
TH_0136|M.thermoresistible__bu VIFGVHDPAEVARLAAPFETLLALAVSVQTPVRYALRRAGALRFWHAYRD
Mvan_0675|M.vanbaalenii_PYR-1 VVFGVHDPESVARFGKPFHELLDLALSEETPVRYALRRFGALRRWGRLSD
MAB_4693|M.abscessus_ATCC_1997 TVIGASDPVRLAALRKVVPRLLYMKP-WETPA-ITNPGLRRYWPWTAVGR
MSMEG_1213|M.smegmatis_MC2_155 TVIGATEPARLAALRHVMPQLLGIGP-WQSLA-IASPGLQRRRPWRTLQR
Mflv_1104|M.gilvum_PYR-GCK AVFGADG-AHLDELRRIIPPWVTLGSRLAVLP-TPHRTYGRFSPWGRLAR
MAV_5160|M.avium_104 AVFGAEG-AELDELRRLIPPWVTLGSRLAALP-KPQR-YPRFGPWGQLDR
MUL_0604|M.ulcerans_Agy99 SVFGLDLQDKADVITTGVTLAAKWAADRSARPVRAPHWLPTP-ARPRARG
MLBr_02088|M.leprae_Br4923 LAFPLAVAVICRLLGVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATE
: :
Rv3685c|M.tuberculosis_H37Rv ANTEIDDVVMALIAQRRADPRLGERHDVLSLLVSARGESGEQLSDSEIRD
Mb3710c|M.bovis_AF2122/97 ANTEIDDVVMALIAQRRADPRLGERHDVLSLLVSARGESGEQLSDSEIRD
MMAR_5175|M.marinum_M AYREIEDVVMPLIAQRRSDLGRTEQRDILGLLISARGDDGEQLSDQEIRD
TH_0136|M.thermoresistible__bu ANRRIDELVRPLIAARR-VPDAGPRDDILSMLVAARTEDGDRLTDDEIRD
Mvan_0675|M.vanbaalenii_PYR-1 ANRRIDELVLPLIAERRSDPLSAERADILSMLANSHTDDGETLSDNEIRD
MAB_4693|M.abscessus_ATCC_1997 RMAETDALLYAEIAERRADPNLTERTDVLAMLVRATDDDGRTMSDQELRD
MSMEG_1213|M.smegmatis_MC2_155 NLAEADRLLYAEIAACRAGPDLASRPDALAMLVRAANDEGRTMTDRELRD
Mflv_1104|M.gilvum_PYR-GCK YRRRYDEVIGRLIDAVQADPNFESRDDVLALLLRSTYEDGSSMSRQDIGD
MAV_5160|M.avium_104 WRRQYDGVIERLIAAEQADPNFAERTDVLALLLRSTYDDGAAMSHKEIGD
MUL_0604|M.ulcerans_Agy99 AYDAMYKIAADMLAACRADPSR-EAPLITALIDATGPNTGESLSDQQICD
MLBr_02088|M.leprae_Br4923 ERLRAGVWLRDYLEQLVKCRRGTPGEDLISRLIELD-ESGDQLTEEEIIA
: . : : * :: ::
Rv3685c|M.tuberculosis_H37Rv DLITLVLAGHETTATTLAWAFDLLLHHPDALRRVRAEAVGGGEA------
Mb3710c|M.bovis_AF2122/97 DLITLVLAGHETTATTLAWAFDLLLHHPDALRRVRAEAVGGGEA------
MMAR_5175|M.marinum_M DLITLMLAGHETTATTLAWVFDLLLHHPDALRRVQEEAEGGTET------
TH_0136|M.thermoresistible__bu DLITLVLAGHETTATTLAWLIDYLVHHPAALDRVRAEAAPGGAQR-----
Mvan_0675|M.vanbaalenii_PYR-1 DLITLVLAGHETTATTLSWLIDLLLHHPRALARVRAEAVSGDTG------
MAB_4693|M.abscessus_ATCC_1997 HLLTSIAAGHETTATALSWVLERLTRHPDALLKAAQAAEASAAGDP----
MSMEG_1213|M.smegmatis_MC2_155 QLMTLLVAGHETTATGLSWTLERLIRHPAVLDKAVAAARTTDG-------
Mflv_1104|M.gilvum_PYR-GCK ELLTLLAAGHETTAATLGWVFERISRHPDVLARLQAEADTDGN-------
MAV_5160|M.avium_104 ELLTLLAAGHETTASTLAWAFERISRHPELLARLVEEADNGGN-------
MUL_0604|M.ulcerans_Agy99 EMVYFMILGEDTTSTVLTYALWALGQHCQLQDRLAAEAAELGDRPLTPAD
MLBr_02088|M.leprae_Br4923 TCGLLLVAGHETTVNLIANAVLAMLRNPSQWKALSSNPQ-----------
: *.:** : . : :: .
Rv3685c|M.tuberculosis_H37Rv -----FTTAVINETLRVRPPAPLTAR-VAAQPLTIGGYRVEAGTRIVVHI
Mb3710c|M.bovis_AF2122/97 -----FTTAVINETLRVRPPAPLTAR-VAAQPLTIGGYRVEAGTRIVVHI
MMAR_5175|M.marinum_M -----FTTAVINETLRVRPPAPFTAR-VAARPFRLGGYLIDPGTRIVVHM
TH_0136|M.thermoresistible__bu -GAGPYTEAVINETLRLRPPGPVTGR-TTAGHYRLGDYTLAPRTRIVLLL
Mvan_0675|M.vanbaalenii_PYR-1 -----YTEAVIAETLRLRPAAPITGR-MTTGPYRLGDYTLEPDTRIVLLL
MAB_4693|M.abscessus_ATCC_1997 -AGDEYLDAVVKETLRIRPVIFSSGR-VLKESVEVGGYQLPVGIMVDPAI
MSMEG_1213|M.smegmatis_MC2_155 -SGEAYLDAVVRESLRIRPVVFEAGR-VLTEPVELGGYLLPAGTLVAPSI
Mflv_1104|M.gilvum_PYR-GCK ----EYRQAVILETQRVRTVIDFAGRHVYAPTFELGEWIIPQGYSIVVAI
MAV_5160|M.avium_104 ----ELRQAAILEVQRARTVIDFAGRHVYPDVYRLGEWVIPRGYSIIVGI
MUL_0604|M.ulcerans_Agy99 VPRLGYTIQVLQEAMRLRPPGPTVAR-RAMQDIEVDGYRVQAGTYCLVGV
MLBr_02088|M.leprae_Br4923 -----RAPLVVEETLRYDPAIHLIGR-VAAKDMTIGQTTLTEGDTMVLLL
.: * * . .* :. : :
Rv3685c|M.tuberculosis_H37Rv IAINRSAEVYEHPHEFRPERFLGTRP---QTYAWVPFGGGVKRCLGANFS
Mb3710c|M.bovis_AF2122/97 IAINRSAEVYEHPHEFRPERFLGTRP---QTYAWVPFGGGVKRCLGANFS
MMAR_5175|M.marinum_M IAINRNPDVYEQPNRFRPERFLGTRP---QTYAWVPFGGGAKRCLGAAFS
TH_0136|M.thermoresistible__bu GVINRDPNSYPDPHDFRPDRFLHTRP---DPYAWVPFGGGVKRCLGAAFA
Mvan_0675|M.vanbaalenii_PYR-1 DVINRNPDTYPQPDEFRPERFLGSRP---HPYAWIPFGGGVKRCIGAAFA
MAB_4693|M.abscessus_ATCC_1997 GLVHASGAVYPDPARFDPDRMVGTTL---SPTTWLPFGGGNRRCLGATFA
MSMEG_1213|M.smegmatis_MC2_155 GLVHASADVYPDPDRFEPDRMLASTQ---APSTWLPFGGGNRRCLGATFA
Mflv_1104|M.gilvum_PYR-GCK GQVHHREQDYLDPEDFDPQRFVGQRP---STLSHIPFGGGTRRCVGAVFA
MAV_5160|M.avium_104 AQIHDNPDVFPDPRRFDPQRFIDNKP---SALSWIPFGGGTRRCVGAAFA
MUL_0604|M.ulcerans_Agy99 YAMHRDPALWDDPLAFDPDRFAPKKSKGRDRWQYLPFGGGGRSCLGDHFA
MLBr_02088|M.leprae_Br4923 AAANRDPAVYSRPDEFDPD-----RP----SSRHLAFAVGSHFCLGAALA
: : * * *: :.*. * : *:* ::
Rv3685c|M.tuberculosis_H37Rv MRELITVLHVLLREGEFTAVDDEPE-RIVRRSIMLVPRRGTRVRFRPAR-
Mb3710c|M.bovis_AF2122/97 MRELITVLHVLLREGEFTAVDDEPE-RIVRRSIMLVPRRGTRVRFRPAR-
MMAR_5175|M.marinum_M MRELVTVLHVLLREGQFTAVDEAPE-RIVRRSIMLAPRHGTRVRFRPRLQ
TH_0136|M.thermoresistible__bu MRELTTILRILLTEADLRPVNARPESAAGRAAAVVVPRHGTPVYFRPTAP
Mvan_0675|M.vanbaalenii_PYR-1 MRELTTTLHTVLREGELEPVSARPETPPLRAAPVLVPRDGTRVRFTPARP
MAB_4693|M.abscessus_ATCC_1997 MVEIRVVLREILRRVELNTTTAPDE-KQQAKHVTFVPHRGGSISVRAIRT
MSMEG_1213|M.smegmatis_MC2_155 LVEMRVVLREILHRVDLFATTARGE-KQRLKHVTMIPHRGGRICVRALRD
Mflv_1104|M.gilvum_PYR-GCK NVEMDIVLRTVFRHFTIETTTAPGE-KMHSRGVAYTPDDGGRVVMRRR--
MAV_5160|M.avium_104 NMEMDVVLRTVLRHFTIETTDAPDE-PWHCRGVAFTPKHGGRIVVHRR--
MUL_0604|M.ulcerans_Agy99 MLEASLALATIIREAEIHSLDGDFPVAIPLPIVPAGPIRARVNQRRPSQE
MLBr_02088|M.leprae_Br4923 RLEATVTLSAISARFPQVQLAGELV---YKPNVAMRGMSALPVQV-----
* * : . .
Rv3685c|M.tuberculosis_H37Rv ------------------------
Mb3710c|M.bovis_AF2122/97 ------------------------
MMAR_5175|M.marinum_M ESV---------------------
TH_0136|M.thermoresistible__bu AASPRCAGRTSTV-----------
Mvan_0675|M.vanbaalenii_PYR-1 AASPRCADRTSTV-----------
MAB_4693|M.abscessus_ATCC_1997 CAPAVTPTCPADVHGTGQARDPQR
MSMEG_1213|M.smegmatis_MC2_155 VAPAP-MTCPAEARRA--------
Mflv_1104|M.gilvum_PYR-GCK ------------------------
MAV_5160|M.avium_104 ------------------------
MUL_0604|M.ulcerans_Agy99 VCTTTLSDSSASS-----------
MLBr_02088|M.leprae_Br4923 ------------------------